Female pregnancy preparation nutrition powder and preparation method thereof

Abstract

The invention discloses a female pregnancy preparation nutrition powder and a preparation method thereof. The female pregnancy preparation nutrition powder comprises the following components in parts by weight: 20-30 parts of concentrated whey protein powder, 35-40 parts of whole milk powder, 20-25 parts of fructo-oligosaccharide, 0.5-1.5 parts of bovine colostrum powder, 2-6 parts of roxburgh rose powder, 2-6 parts of rhizoma polygonati powder, 2-6 parts of rehmannia powder, 0.3-0.7 part of composite vitamins and 2-6 parts of composite minerals. According to the nutritional requirements of women in the pregnancy preparation period, the nutrient design is scientific and reasonable, the nutrient deficiency of the maternal body is corrected, oxidation is resisted, the immunity is improved, the intestinal function is adjusted, the constitution is conditioned in combination with traditional Chinese medicine, and the health of the maternal body reaches the optimal state. Heat-sensitive components are protected technically, interaction among the components is avoided, product uniformity is ensured, solubility and taste are improved, nitrogen is charged for packaging to prevent oxidation, and the sensitive components are protected; the growth of microorganisms is inhibited; caking and texture deterioration are prevented; the shelf life is prolonged.

Description

Technical Field

[0001] The present invention relates to the research and development of functional foods or nutritional supplements, which are designed to meet the special nutritional needs of women in the pregnancy preparation period. The preparation method involves specific processes for powder processing (such as weighing, premixing, sieving, total mixing, nitrogen filling, inner packaging, etc.), specifically a nutritional powder for women in the pregnancy preparation period and a preparation method thereof. Background Art

[0002] In recent years, with rising health awareness and delayed childbearing ages, market demand for women's nutritional supplements for pregnancy preparation has grown rapidly. However, current women's nutritional supplements for pregnancy preparation primarily focus on vitamins and minerals, often with single-source supplements and nutrient ratios that may not be suitable for Chinese mothers' constitutions. Some products simply stack high doses of vitamins and minerals (such as excessive iron, calcium, and vitamin A), potentially causing toxic side effects (such as iron overload and the risk of vitamin A teratogenicity). Furthermore, the design of vitamins and minerals is irrational, and most women's nutritional supplements for pregnancy preparation on the market are in tablet form, which is heavy and difficult for consumers to swallow. Summary of the Invention

[0003] Purpose of the invention: The purpose of the present invention is to provide a nutritional powder for women preparing for pregnancy, which can enhance physical fitness and supplement nutrition while providing reasonable nutritional supplements for female fertility. Another purpose of the present invention is to provide a method for preparing the nutritional powder for women preparing for pregnancy.

[0004] Technical Solution: The nutritional powder for women preparing for pregnancy of the present invention comprises the following components by weight: 20-30 parts of concentrated whey protein powder, 35-40 parts of whole milk powder, 20-25 parts of oligofructose, 0.5-1.5 parts of bovine colostrum powder, 2-6 parts of roxburghii powder, 2-6 parts of polygonatum powder, 2-6 parts of rehmannia powder, 0.3-0.7 parts of multivitamins, and 2-6 parts of multiminerals. Preferably, the recommended daily dosage of the nutritional powder for women preparing for pregnancy is 15-20g.

[0005] The multivitamin contains: retinyl acetate 1973.40-2960.10 μg / g, cholecalciferol 27.84-41.76 μg / g, d1-α-tocopheryl acetate 33.60-50.40 mg / g, phytonadione 185.60-278.40 μg / g, thiamine hydrochloride 4.96-7.44 mg / g, riboflavin 4.64-6.96 mg / g, pyridoxine hydrochloride 7. 84-11.76mg / g, cyanocobalamin 9.60-14.40μg / g, niacin 32.40-48.60mg / g, 6S-5-methyltetrahydrofolate calcium 1476.07-1997.03μg / g, D-pantothenate calcium 16.81-25.22mg / g, D-biotin 123.20-184.80μg / g, L-ascorbic acid 324.80-487.20mg / g.

[0006] The composite mineral contains: magnesium 74.38-100.63 mg / g, calcium 255.00-345.00 mg / g, iron 7.33-9.92 mg / g, zinc 2.80-3.80 mg / g, and selenium 15.20-20.56 μg / g.

[0007] Magnesium comes from magnesium oxide, calcium comes from calcium carbonate, iron comes from ferric pyrophosphate, zinc comes from zinc gluconate, and selenium comes from sodium selenite.

[0008] The roxburgh roxburgh powder is roxburgh roxburgh powder, roxburgh roxburgh juice powder or roxburgh roxburgh extract powder.

[0009] The polygonatum powder is polygonatum powder or polygonatum extract powder.

[0010] The Rehmannia root powder is Rehmannia root powder or Rehmannia root extract powder.

[0011] The preparation method of the nutritional powder for women preparing for pregnancy comprises the following steps:

[0012] (1) Weighing of raw materials;

[0013] (2) Premixing: Using paddle mixing, add bovine colostrum powder, multivitamins, and multiminerals into the premixer in sequence for premixing;

[0014] (3) Total mixing: using a ribbon mixer, whole milk powder, oligofructose, roxburghii powder, polygonatum powder, rehmannia powder, premix, and concentrated whey protein powder are sequentially added to the ribbon mixer for total mixing;

[0015] (4) Inner packaging, filled with nitrogen;

[0016] (5) Outer packaging.

[0017] In the preparation method, in step (2), the speed of the premixer is 20-60 Hz, and the mixing time is 1-10 min.

[0018] In the preparation method, in step (3), the speed of the ribbon mixer is 20-60 Hz, and the mixing time is 10-30 min.

[0019] The product formula is designed to optimize maternal health, regulate physical fitness, and provide basic nutritional support for fetal development, mainly addressing the following issues:

[0020] Correct nutritional deficiencies: activated folate, iron, vitamin B 12 , iodine, zinc, vitamin D3

[0021] Function: neural tube defects (folic acid deficiency), prevention of anemia (iron deficiency), abnormal thyroid function (iodine deficiency), etc., to ensure adequate maternal nutritional reserves.

[0022] Support egg quality: Rosa roxburghii powder, vitamin C, vitamin E, selenium

[0023] Function: Anti-oxidation, neutralize free radicals, protect egg cells

[0024] Enhance immunity: bovine colostrum powder, concentrated whey protein powder

[0025] Function: Provide high-quality protein, immunoglobulin, enhance body immunity

[0026] Regulate intestinal function: oligofructose

[0027] Function: Water-soluble dietary fiber, prebiotics improve intestinal function

[0028] Conditioning body constitution: Polygonatum sibiricum powder, Rehmannia root powder

[0029] Function: Nourishes yin and kidney, regulates endocrine system, improves qi and blood, and improves the quantity and quality of follicles

[0030] Mental and energy support: B vitamins (especially B6, B9, B 12 ),magnesium

[0031] Effects: Relieve stress during pregnancy preparation, improve sleep (magnesium), maintain energy metabolism (B vitamins)

[0032] The preparation process mainly solves the following key issues to ensure the safety, nutritional activity and use effect of the product:

[0033] 1. Stability protection of heat-sensitive nutrients

[0034] Problem: Folic acid, B vitamins, etc. are easily decomposed by heat, and traditional wet granulation or high-temperature sterilization will destroy their activity.

[0035] Advantages of dry process: No high temperature treatment throughout the process, mixing at room temperature (usually ≤30℃), retaining the integrity of nutrients.

[0036] For example: the retention rate of active folic acid (5-methyltetrahydrofolate) can reach more than 95%.

[0037] 2. Solve the failure caused by the interaction between components

[0038] Problem: Iron ions are prone to oxidation or chelation reactions with minerals such as vitamin C, calcium and zinc in a wet environment.

[0039] Dry process optimization: step-by-step mixing: premix first, then gradually add other raw materials.

[0040] 3. Ensure powder uniformity and dosage accuracy

[0041] Problem: Nutrients (such as folic acid and iodine) require extremely low doses (microgram level), and uneven mixing may lead to local overdose or deficiency.

[0042] Process control: Use a paddle mixer for premixing and a ribbon mixer for final mixing, and the mixing uniformity should reach RSD ≤ 10%.

[0043] 4. Avoid the risk of microbial contamination

[0044] Problem: Wet granulation requires the addition of water, which may introduce microorganisms (such as Salmonella) and require subsequent sterilization.

[0045] Dry process solution: fully enclosed production line, temperature and humidity are controlled in clean workshops in clean working areas to avoid secondary contamination.

[0046] 5. Improve solubility and taste

[0047] Problem: Traditional processes may cause agglomeration and poor solubility due to compression or adhesives.

[0048] Dry process improvement: control particle size and enhance dispersibility.

[0049] 6. Process efficiency and cost optimization

[0050] Problem: Wet granulation requires multiple steps such as drying and granulation, which results in high energy consumption and a long cycle.

[0051] Benefits of dry process: Simplified process: mixing and packaging are completed in one step, and production efficiency is increased by 30%-50%.

[0052] Reduce energy consumption: No drying equipment is required, suitable for small batch customized production.

[0053] 7. Packaging: Nitrogen-filled packaging

[0054] Nitrogen filling packaging is a key process that mainly solves the following core issues to ensure product quality, safety and effectiveness:

[0055] Prevent oxidation and protect sensitive ingredients; inhibit microbial growth; prevent caking and texture deterioration; mask unpleasant odors; extend shelf life

[0056] The core goal of this product is to optimize maternal health and create an optimal physiological environment for conception and early fetal development. Specifically, it addresses the following key issues: addressing specific nutritional gaps during pregnancy preparation; conditioning the body; and optimizing reproductive system function.

[0057] Nutrition labeling after product testing:

[0058]

[0059]

[0060] The present invention supplements vitamins and minerals while supplementing essential nutrients needed by women preparing for pregnancy, such as high-quality protein, water-soluble dietary fiber, and bovine colostrum containing immunoglobulins. In addition, the vitamins and minerals in the present invention are scientifically and rationally designed and more suitable for the physique of Chinese mothers. For example, Chinese mothers are more likely to lack folic acid, VC, iron, calcium, etc., but are less likely to lack phosphorus, copper, manganese, iodine, etc.

[0061] The present invention is edible in the form of a dry powder, which has good solubility, a good taste, is convenient for consumers to eat, and has a high digestion and absorption rate. In addition, the dry process can effectively protect sensitive ingredients such as vitamin C, vitamin E, folic acid and other easily degradable ingredients.

[0062] Beneficial Effects: Compared with the prior art, the present invention has the following advantages: (1) The product formula of the present invention is scientifically and rationally designed based on the nutritional needs of women during the pregnancy preparation period, correcting maternal nutrient deficiencies, anti-oxidation, enhancing immunity, regulating intestinal function, and combining it with Chinese medicine to regulate the body constitution, so that the mother's health reaches the optimal state, cultivating the most fertile land for the fetus. (2) The preparation process of the present invention can protect heat-sensitive ingredients, avoid interactions between ingredients, ensure product uniformity, improve solubility and taste, and nitrogen filling on the packaging can prevent oxidation, protect sensitive ingredients; inhibit microbial growth; prevent caking and texture deterioration; and extend shelf life. BRIEF DESCRIPTION OF THE DRAWINGS

[0063] Figure 1 It is the process route diagram of the present invention. DETAILED DESCRIPTION

[0064] All reagents involved in the present invention were purchased through commercial channels.

[0065] Whey protein concentrate powder was purchased from Qingdao Mensa Food Co., Ltd.

[0066] Whole milk powder was purchased from Tianjin Yinhe Weiye Import and Export Co., Ltd.

[0067] Fructooligosaccharide was purchased from Baolingbao Biological Co., Ltd.

[0068] Bovine colostrum powder was purchased from Qingdao Mensa Food Co., Ltd.

[0069] Rosa roxburghii powder was purchased from Nanjing Zelang Biotechnology Co., Ltd.

[0070] Polygonatum sibiricum powder was purchased from Nanjing Zelang Biotechnology Co., Ltd.

[0071] Rehmannia root powder was purchased from Nanjing Zelang Biotechnology Co., Ltd.

[0072] Multivitamins were purchased from Zhengzhou Ruipu Bioengineering Co., Ltd.

[0073] Composite minerals were purchased from Zhengzhou Ruipu Bioengineering Co., Ltd.

[0074] Example 1

[0075] (1) Raw material weighing

[0076] Product 600kg batch: 165.6kg concentrated whey protein powder; 210kg whole milk powder; 120kg fructooligosaccharide; 6kg bovine colostrum powder; 18kg sea buckthorn powder; 24kg polygonatum powder; 30kg rehmannia powder; 2.4kg multivitamins; 24kg multiminerals.

[0077] (2) Premixing: Use the paddle to mix at a speed of 30 Hz and a mixing time of 3 min.

[0078] Put bovine colostrum powder, multivitamins and multiminerals into the premixer in sequence and premix according to the premixing parameters.

[0079] (3) Total mixing, ribbon mixing, speed: 40 Hz, mixing time: 20 min.

[0080] Add whole milk powder, oligofructose, roxburghii powder, polygonatum powder, rehmannia powder, premix and concentrated whey protein powder in sequence and mix according to the total mixing parameters.

[0081] (4) Inner packaging, filled with nitrogen

[0082] The product is packed into 20g / bag.

[0083] (5) Outer packaging

[0084] The product is packaged in boxes of 20g x 15 bags.

[0085] The process route diagram of the present invention is as follows: Figure 1 shown.

[0086] Example 2

[0087] (1) Raw material weighing

[0088] Product 600kg batch: 156kg concentrated whey protein powder; 220kg whole milk powder; 125kg fructooligosaccharide; 6kg bovine colostrum powder; 18kg roxburghii powder; 24kg polygonatum powder; 24kg rehmannia powder; 3.0kg multivitamins; 24kg multiminerals.

[0089] (2) Premixing: Use the paddle to mix at a speed of 35 Hz and a mixing time of 5 min.

[0090] Put bovine colostrum powder, multivitamins and multiminerals into the premixer in sequence and premix according to the premixing parameters.

[0091] (3) Total mixing, ribbon mixing, speed: 35 Hz, mixing time: 20 min.

[0092] Add whole milk powder, oligofructose, roxburghii powder, polygonatum powder, rehmannia powder, premix and concentrated whey protein powder in sequence and mix according to the total mixing parameters.

[0093] (4) Inner packaging, filled with nitrogen

[0094] The product is packed into 20g / bag.

[0095] (5) Outer packaging

[0096] The product is packaged in boxes of 20g x 15 bags.

[0097] Example 3

[0098] (1) Raw material weighing

[0099] Product 600kg batch: 161kg concentrated whey protein powder; 210kg whole milk powder; 125kg oligofructose; 5kg bovine colostrum powder; 24kg roxburghii powder; 24kg polygonatum powder; 24kg rehmannia powder; 3.0kg multivitamins; 24kg multiminerals.

[0100] (2) Premixing: Use the paddle to mix at a speed of 35 Hz and a mixing time of 5 min.

[0101] Put bovine colostrum powder, multivitamins and multiminerals into the premixer in sequence and premix according to the premixing parameters.

[0102] (3) Total mixing, ribbon mixing, speed: 35 Hz, mixing time: 20 min.

[0103] Add whole milk powder, oligofructose, roxburghii powder, polygonatum powder, rehmannia powder, premix and concentrated whey protein powder in sequence and mix according to the total mixing parameters.

[0104] (4) Inner packaging, filled with nitrogen

[0105] The product is packed into 20g / bag.

[0106] (5) Outer packaging

[0107] The product is packaged in boxes of 20g x 15 bags.

[0108] Comparative Example 1

[0109] Compared with Example 1, the difference is that the whole milk powder, bovine colostrum powder and roxburghii powder are removed.

[0110] Comparative Example 2

[0111] Compared with Example 1, the difference is that the concentrated whey protein powder and oligofructose are removed.

[0112] Comparative Example 3

[0113] Compared with Example 1, the difference is that the polygonatum powder and rehmannia powder are removed.

[0114] Effect Example 1

[0115] Preparation and sensory evaluation

[0116] Weigh 20 g of each of the female pregnancy preparation nutritional powders obtained in Examples 1-3 and Comparative Examples 1-3 and pour them into a container, mix with 90°C warm water, stir continuously until a uniform solution is formed, let it stand for 20 minutes, and observe the state of the prepared solution. The sample evaluation basis is shown in Table 1, and the preparation comparison results are shown in Table 2.

[0117] Table 1 Sample evaluation basis

[0118]

[0119]

[0120] Table 2 Comparison results of brewing

[0121]

[0122]

[0123] It can be seen from the above table that the female pregnancy preparation nutritional powder obtained in Examples 1-3 of the present invention has good solubility after mixing, no lumps, a moderate milky taste and sweetness, is easily accepted by consumers, and has no stratification or precipitation after standing.

[0124] Effect Example 2

[0125] Improving female mouse reproductive studies

[0126] 1. Experimental Animals and Grouping

[0127] After one week of adaptive feeding, ICR female mice were randomly divided into four groups according to body weight. The daily operation was as follows:

[0128] The control group (Control) was injected intraperitoneally with an equal volume of normal saline;

[0129] Model group: intraperitoneal injection of D-galactose (D-Gal) 300 mg / kg.bw;

[0130] Low-dose group (LG): intraperitoneal injection of D-Gal (300 mg / kg.bw) + oral administration of 3 g / kg of the female pregnancy preparation nutritional powder prepared in Example 1;

[0131] High-dose group of female pregnancy preparation nutritional powder (HG): intraperitoneal injection of D-Gal (300 mg / kg.bw) + oral gavage of female pregnancy preparation nutritional powder prepared in Example 1 6 g / kg.

[0132] The experiment lasted 12 weeks.

[0133] 2. Index determination

[0134] Measure and record body weight every week

[0135] At the end of the experiment

[0136] Measurement of serum hormone levels: estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH)

[0137] Determination of serum oxidative stress indicators: malondialdehyde (MDA), glutathione peroxidase (SOD), reduced glutathione (GSH)

[0138] Determination of serum inflammatory factor indicators: TNF-α, TGF-β1, IL-4, IL-6

[0139] 3. Experimental Results

[0140] (1) Sex hormone levels: The serum estradiol level in the D-Gal model group was significantly lower than that in the control group, while the estradiol level in the LG group was significantly higher than that in the model group. The serum progesterone level in the D-Gal model group was significantly higher than that in the control group, while the progesterone levels in the LG and HG groups were significantly lower than those in the model group.

[0141] The serum LH level in the D-Gal model group was significantly higher than that in the control group, while the LH level in the LG and HG groups was significantly lower than that in the model group. The serum FSH level in the D-Gal model group was significantly higher than that in the control group, while the FSH level in the HG group was significantly lower than that in the model group.

[0142] (2) Oxidative stress indicators: The serum MDA level in the D-Gal model group was significantly higher than that in the control group, while the MDA level in the HG group was significantly lower than that in the model group. The serum GSH level in the D-Gal model group was not significantly different from that in the control group, but the GSH level in the HG group was significantly higher than that in the model group. The serum SOD level in the D-Gal model group was significantly lower than that in the control group, while the SOD levels in the LG and HG groups were significantly higher than those in the model group.

[0143] (3) Levels of inflammatory factors: The serum IL-4 level in the D-Gal model group was significantly lower than that in the control group, while the IL-4 levels in the LG and HG groups were significantly higher than those in the model group. The serum TNF-β1 level in the D-Gal model group was significantly higher than that in the control group, while the TNF-β1 level in the LG group was significantly lower than that in the model group. The serum TNF-α level in the D-Gal model group was significantly higher than that in the control group, while the TNF-α level in the LG and HG groups was significantly lower than that in the model group. There was no significant difference in IL-6 levels among the groups.

[0144] (4) Increased pregnancy rate

[0145] Group total Number of pregnancies pregnancy rate Blank control group 6 4 66.7％ D-Gal group 5 2 40％ Low-dose group 5 4 80％ High-dose group 5 3 60％

[0146] Conclusion: The female pregnancy preparation powder significantly improved reproductive hormone levels in female mice, reduced oxidative stress and inflammation, demonstrated a protective effect on the female reproductive system, and increased conception rates. The researchers hypothesized that the high-dose group experienced an antagonistic effect due to excessive nutritional intake, which increased the gastrointestinal burden of the mice. According to the human equivalent dose (HED, mg / kg) = animal dose (mg / kg) × (animal Km coefficient / human Km coefficient), the low-dose group (3g / kg / day) calculated based on an average adult weight of 60kg is: 0.243 × 60 = 14.6g / person, approximately 15g / person. The high-dose group (6g / kg / day) calculated based on an average adult weight of 60kg is: 0.486 × 60 = 29.2g / person, approximately 30g / person. Based on the animal study results, the recommended daily dosage for adults is one 20g bag.

Claims

1. A nutritional powder for women preparing for pregnancy, characterized in that: The invention comprises the following components in parts by weight: 20-30 parts of concentrated whey protein powder, 35-40 parts of whole milk powder, 20-25 parts of oligofructose, 0.5-1.5 parts of bovine colostrum powder, 2-6 parts of roxburghii powder, 2-6 parts of polygonatum powder, 2-6 parts of rehmannia powder, 0.3-0.7 parts of complex vitamins and 2-6 parts of complex minerals.

2. The female pregnancy preparation nutritional powder according to claim 1, characterized in that The multivitamin contains: retinyl acetate 1973.40-2960.10 μg / g, cholecalciferol 27.84-41.76 μg / g, dl-α-tocopheryl acetate 33.60-50.40 mg / g, phytonadione 185.60-278.40 μg / g, thiamine hydrochloride 4.96-7.44 mg / g, riboflavin 4.64-6.96 mg / g, pyridoxine hydrochloride 7. 84-11.76mg / g, cyanocobalamin 9.60-14.40μg / g, niacin 32.40-48.60mg / g, 6S-5-methyltetrahydrofolate calcium 1476.07-1997.03μg / g, D-pantothenate calcium 16.81-25.22mg / g, D-biotin 123.20-184.80μg / g, L-ascorbic acid 324.80-487.20mg / g.

3. The female pregnancy preparation nutritional powder according to claim 1, characterized in that The composite mineral contains: magnesium 74.38-100.63 mg / g, calcium 255.00-345.00 mg / g, iron 7.33-9.92 mg / g, zinc 2.80-3.80 mg / g, and selenium 15.20-20.56 μg / g.

4. The female pregnancy preparation nutritional powder according to claim 3, characterized in that Magnesium comes from magnesium oxide, calcium comes from calcium carbonate, iron comes from ferric pyrophosphate, zinc comes from zinc gluconate, and selenium comes from sodium selenite.

5. The female pregnancy preparation nutritional powder according to claim 1, characterized in that The roxburgh roxburgh powder is roxburgh roxburgh powder, roxburgh roxburgh juice powder or roxburgh roxburgh extract powder.

6. The female pregnancy preparation nutritional powder according to claim 1, characterized in that The polygonatum powder is polygonatum powder or polygonatum extract powder.

7. The female pregnancy preparation nutritional powder according to claim 1, characterized in that The Rehmannia root powder is Rehmannia root powder or Rehmannia root extract powder.

8. A method for preparing the female pregnancy preparation nutritional powder according to claim 1, characterized in that: The following steps are involved: (1) Weighing of raw materials; (2) Premixing: Using paddle mixing, add bovine colostrum powder, multivitamins, and multiminerals into the premixer in sequence for premixing; (3) Total mixing: using a ribbon mixer, whole milk powder, oligofructose, roxburghii powder, polygonatum powder, rehmannia powder, premix, and concentrated whey protein powder are sequentially added to the ribbon mixer for total mixing; (4) Inner packaging, filled with nitrogen; (5) Outer packaging.

9. The preparation method according to claim 8, characterized in that In step (2), the speed of the premixer is 20-60 Hz, and the mixing time is 1-10 min.

10. The preparation method according to claim 8, characterized in that In step (3), the speed of the ribbon mixer is 20-60 Hz, and the mixing time is 10-30 min.

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