Composition for reducing penetration of sun-screening agent into skin and application of composition

Abstract

The invention relates to a composition for reducing penetration of a sun-screening agent into skin and application of the composition. The composition for reducing penetration of the sun-screening agent into the skin comprises a water-soluble suspension thickening agent and an oil-soluble thickening agent, the mass ratio of the water-soluble suspension thickening agent to the oil-soluble thickening agent is (0.1-3): (0.1-6). The composition is composed of the water-soluble suspension thickening agent and the oil-soluble suspension thickening agent, the water-soluble suspension thickening agent and the oil-soluble suspension thickening agent cooperate with each other, the composition has a remarkable inhibition effect on percutaneous penetration of water-soluble and oil-soluble sun-screening agents, penetration of the sun-screening agents in skin can be remarkably reduced, and then irritation and potential hazards of the sun-screening agents can be remarkably reduced; the sunscreen effect of the product is improved, and meanwhile the safety performance of the product is better.

Description

Technical Field

[0001] The invention belongs to the technical field of daily cosmetics, and particularly relates to a composition for reducing the penetration of sunscreen agents into the skin and an application thereof. Background Art

[0002] Sunscreen cosmetics refer to products that can help consumers protect themselves from UV damage. They are generally made by adding organic and inorganic sunscreens to achieve the sunscreen effect. However, sunscreens, especially small molecules less than 500 Daltons, can easily penetrate human skin and enter the human blood, which may cause adverse effects. In the prior art, some technologies embed or encapsulate sunscreens to reduce the penetration of sunscreens into the skin, solving the problems that may be caused by sunscreens penetrating into the skin.

[0003] CN112932994A discloses a sunscreen composition for reducing the percutaneous penetration of sunscreen agents, wherein the composition comprises a thickener selected from the group consisting of xanthan gum, acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, sclerotium gum or a combination thereof. The invention also relates to a method for reducing the percutaneous penetration of sunscreen agents and the use of a specific thickener in a sunscreen composition capable of reducing the percutaneous penetration of sunscreen agents.

[0004] CN104644463A discloses a lipophilic chemical sunscreen coating and a method for making it. At present, there are some studies on the coating technology of chemical sunscreen OMC, but these studies are all characterized and studied on its stability, and the influence on its transdermal penetration is not studied, and the stability is greatly improved, but the ability to absorb ultraviolet rays is also correspondingly reduced, indicating that the above coating still has serious defects, and the disadvantages outweigh the advantages. The invention composition includes: gelatin, polyphosphate, lipophilic chemical sunscreen, water, and the gelatin weight parts are 3-5, the polyphosphate weight parts are 0.2-0.5, the lipophilic chemical sunscreen weight parts are 5-10, and the water weight parts are 25-55. The invention is used for lipophilic chemical sunscreen coating.

[0005] However, the above-mentioned prior art is wrapped and embedded, and the process is complicated, which significantly increases the use cost of sunscreen, and the effect of inhibiting the penetration of sunscreen is not good. Therefore, it is of great significance to develop a technology with a simple formula and a significant inhibitory effect on the transdermal penetration of both water-soluble and oil-soluble sunscreens. Summary of the invention

[0006] In view of the deficiencies of the prior art, the object of the present invention is to provide a composition for reducing the penetration of sunscreen into the skin and its application, which can reduce the percutaneous penetration of sunscreen, thereby reducing the irritation of sunscreen to the skin and improving the safety of the product.

[0007] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0008] In a first aspect, the present invention provides a composition for reducing the penetration of sunscreen into the skin, the composition for reducing the penetration of sunscreen into the skin comprising a water-soluble suspending thickener and an oil-soluble thickener;

[0009] The mass ratio of the water-soluble suspension thickener to the oil-soluble thickener is (0.1-3):(0.1-6).

[0010] Wherein “0.1-3” can be 0.3, 0.5, 0.7, 0.9, 1, 1.3, 1.5, 1.8, 2, 2.1, 2.3, 2.5, 2.7 or 2.9, etc.;

[0011] “0.1-6” can mean 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5 or 5.5, etc.

[0012] The composition of the present invention is composed of a water-soluble suspension thickener and an oil-soluble suspension thickener, which work synergistically to significantly inhibit the transdermal penetration of water-soluble and oil-soluble sunscreens, and can significantly reduce the penetration of sunscreens in the skin, thereby significantly reducing the irritation and potential harm of sunscreens, thereby improving the sunscreen effect of the product and making the safety performance of the product better.

[0013] Preferably, the water-soluble suspension thickener includes any one or a combination of at least two of xanthan gum, acrylic acid (esters) / C10-30 alkyl acrylate crosspolymer, ammonium acryloyldimethyltaurate / VP copolymer, ammonium acryloyldimethyltaurate / behenyl alcohol polyether-25 methacrylate crosspolymer, polyacrylate crosspolymer-6, acrylic acid (esters) / vinyl isodecanoate crosspolymer or acrylic acid (esters) copolymer.

[0014] Preferably, the water-soluble suspension thickener is a combination of xanthan gum and ammonium acryloyldimethyltaurate / VP copolymer.

[0015] In the present invention, the xanthan gum and ammonium acryloyldimethyltaurate / VP copolymer have a synergistic effect in reducing the transdermal penetration of water-soluble sunscreens. The combination of the two can reduce the adverse effects and hazards of sunscreens on the human body, increase their ultraviolet absorption efficiency, and thus provide more effective protection for the skin.

[0016] Preferably, the mass ratio of the xanthan gum to ammonium acryloyldimethyltaurate / VP copolymer is 1:(2-8), for example, it can be 1:2.5, 1:3, 1:3.5, 1:4, 1:4.5, 1:5, 1:5.5, 1:6, 1:6.5, 1:7 or 1:7.5, etc.

[0017] Preferably, the oil-soluble thickener comprises any one or a combination of at least two of HDI / trimethylol hexyl lactone cross-linked polymer, adipic acid / diethylene glycol / glycerol cross-linked polymer, butene / ethylene / styrene copolymer, hydrogenated (styrene / isoprene) copolymer or hydrogenated (styrene / butadiene) copolymer.

[0018] Preferably, the oil-soluble thickener is a combination of HDI / trimethylol hexyl lactone cross-linked polymer and adipic acid / diethylene glycol / glycerol cross-linked polymer.

[0019] In the present invention, the oil-soluble thickener is a combination of HDI / trimethylol hexyl lactone cross-linked polymer and adipic acid / diethylene glycol / glycerol cross-linked polymer, which can reduce the direct contact between the oily sunscreen and the skin, thereby reducing its irritation to the skin and greatly increasing the safety of the sunscreen.

[0020] Preferably, the mass ratio of the HDI / trimethylol hexyl lactone cross-linked polymer to the adipic acid / diethylene glycol / glycerol cross-linked polymer is 1:(0.1-1), for example, it can be 1:0.2, 1:0.4, 1:0.5, 1:0.7 or 1:0.9, etc.

[0021] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0022] In a second aspect, the present invention provides a use of the composition for reducing skin penetration of sunscreen agents as described in the first aspect in the preparation of sunscreen products.

[0023] Preferably, the mass percentage of the composition for reducing skin penetration of sunscreen agents in the sunscreen product is 1-10%, for example, it can be 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9% or 9.5%, etc.

[0024] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0025] In a third aspect, the present invention provides a sunscreen lotion, wherein the components of the sunscreen lotion include, by weight, 1-10 parts of the composition for reducing skin penetration of sunscreen agents as described in the first aspect, 5-15 parts of an oil solvent, 1-5 parts of an emulsifier, 5-20 parts of a sunscreen agent, and 10-90 parts of deionized water.

[0026] The sunscreen lotion of the present invention can reduce the skin penetration of the sunscreen by adding a composition that reduces the penetration of the sunscreen into the skin, thereby reducing the irritation of the sunscreen product. In addition, the raw materials used in the sunscreen lotion of the present invention are all commonly used raw materials for cosmetics, and thus the cost of the product will not be increased.

[0027] The amount of the composition for reducing the penetration of sunscreen into the skin in the sunscreen lotion of the present invention can be 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts or 9.5 parts, etc.;

[0028] The amount of the oil solvent added can be 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts, etc.;

[0029] The amount of the emulsifier added can be 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts or 4.5 parts, etc.;

[0030] The amount of the sunscreen added can be 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts or 19 parts, etc.;

[0031] The added amount of the deionized water can be 15 parts, 20 parts, 30 parts, 40 parts, 50 parts, 60 parts, 70 parts, 80 parts or 85 parts, etc.

[0032] Preferably, the emulsifier includes any one of cetearyl alcohol, cetearyl glucoside, sodium stearoyl glutamate, glycerin or inulin lauryl carbamate, or a combination of at least two thereof.

[0033] Preferably, the emulsifier is a combination of cetearyl alcohol, cetearyl glucoside, sodium stearoyl glutamate, glycerin and inulin lauryl carbamate.

[0034] Preferably, the sunscreen comprises a water-soluble sunscreen and / or an oil-soluble sunscreen.

[0035] Preferably, the water-soluble sunscreen agent includes any one of phenylbenzimidazole sulfonic acid, methylene bis-benzotriazolyl tetramethylbutylphenol, benzylene camphor sulfonic acid or PEG-25 p-aminobenzoic acid, or a combination of at least two thereof.

[0036] Preferably, the oil-soluble sunscreen includes any one of octocrylene, bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, ethylhexyl methoxycinnamate, ethylhexyl salicylate, diethylhexyl butyramido triazone or polysilicone-15, or a combination of at least two thereof.

[0037] Preferably, the sunscreen comprises phenylbenzimidazole sulfonic acid and / or octocrylene.

[0038] Preferably, the sunscreen is phenylbenzimidazole sulfonic acid and octocrylene.

[0039] Preferably, the mass ratio of phenylbenzimidazole sulfonic acid to octocrylene is 1:(1-5), for example, 1:1.5, 1:2, 1:2.5, or 1:3.

[0040] Preferably, the sunscreen lotion further comprises any one of a pH regulator, a fragrance or a preservative, or a combination of at least two of them.

[0041] Preferably, the pH adjusting agent comprises arginine.

[0042] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0043] In a fourth aspect, the present invention provides a method for preparing the sunscreen lotion as described in the third aspect, the preparation method comprising stirring a composition for reducing skin penetration of sunscreen, an oil solvent, an emulsifier and a sunscreen in deionized water to obtain the sunscreen lotion.

[0044] The preparation method of the sunscreen lotion provided by the invention has simple operation steps, low cost and is easy for industrial large-scale production.

[0045] Preferably, the preparation method comprises:

[0046] (1) stirring and mixing a water-soluble sunscreen agent in a portion of deionized water to obtain a premix phase;

[0047] (2) mixing and stirring a water-soluble suspension thickener, sodium stearoyl glutamate, glycerin and inulin lauryl carbamate in the remaining deionized water to obtain an aqueous phase;

[0048] (3) mixing and stirring an oil-soluble thickener, cetearyl alcohol, cetearyl glucoside, an oil solvent, and an oil-soluble sunscreen to obtain an oil phase;

[0049] (4) adding the oil phase to the water phase, mixing and stirring, and then cooling;

[0050] (5) Then add the premixed phase, mix and stir to obtain the sunscreen lotion.

[0051] Preferably, the portion of deionized water in step (1) is 5-15% of the total amount of deionized water, for example, it can be 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13% or 14%, etc.

[0052] Preferably, the stirring speed in step (1) is 200-500 rpm, and the time is 5-20 min. For example, the speed may be 300 rpm, 400 rpm, 450 rpm or 500 rpm, and the time may be 6 min, 8 min, 10 min, 13 min, 15 min, 17 min or 19 min, etc.

[0053] Preferably, the rotation speed of the mixing and stirring in step (2) is 500-1500 rpm, for example, it can be 550 rpm, 800 rpm, 1000 rpm, 1200 rpm or 1500 rpm.

[0054] Preferably, the temperature during the mixing and stirring in step (2) is 70-90°C, and the time is 10-30 min. For example, the time can be 71°C, 73°C, 75°C, 78°C, 80°C, 82°C, 85°C, 87°C or 89°C, and the time can be 12 min, 15 min, 18 min, 20 min, 22 min, 25 min or 28 min, etc.

[0055] Preferably, the rotation speed of the mixing and stirring in step (3) is 1000-3000 rpm, for example, it can be 1200 rpm, 1500 rpm, 1800 rpm, 2000 rpm, 2200 rpm, 2500 rpm or 2800 rpm.

[0056] Preferably, the temperature during the mixing and stirring in step (3) is 70-90°C, and the time is 5-20 min. For example, the time can be 71°C, 73°C, 75°C, 78°C, 80°C, 82°C, 85°C, 87°C or 89°C, and the time can be 6 min, 8 min, 10 min, 12 min, 15 min, 17 min or 19 min, etc.

[0057] Preferably, the rotation speed of the mixing and stirring in step (4) is 5000-10000 rpm, for example, it can be 6000 rpm, 7000 rpm, 8000 rpm or 9000 rpm.

[0058] Preferably, the temperature during the mixing and stirring in step (4) is 70-80°C and the time is 5-15 min. For example, the temperature can be 71°C, 73°C, 75°C, 77°C or 79°C, and the time can be 6 min, 8 min, 10 min, 12 min or 14 min.

[0059] Preferably, the cooling temperature in step (4) is 40-45°C, for example, 40°C, 42°C, 43°C, 44°C or 45°C.

[0060] Preferably, the mixing stirring speed in step (5) is 300rpm-1500rpm, and the stirring time is 5-10min. For example, the stirring speed can be 400rpm, 500rpm, 800rpm, 1000rpm, 1200rpm or 1500rpm, and the time can be 5min, 6min, 7min, 8min, 9min or 10min, etc.

[0061] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0062] Compared with the prior art, the present invention has the following beneficial effects:

[0063] (1) The composition of the present invention is composed of a water-soluble suspension thickener and an oil-soluble suspension thickener, which work together to significantly inhibit the transdermal penetration of water-soluble and oil-soluble sunscreens, and can significantly reduce the penetration of sunscreens in the skin, thereby significantly reducing the irritation and potential harm of sunscreens, thereby improving the sunscreen effect of the product and making the product's safety performance better.

[0064] (2) The sunscreen lotion of the present invention can reduce the percutaneous penetration of the sunscreen by adding a composition that reduces the penetration of the sunscreen into the skin, thereby reducing the irritation of the sunscreen product. In addition, the raw materials used in the sunscreen lotion of the present invention are all commonly used raw materials for cosmetics, and no additional processing of the raw materials is required, thereby not increasing the cost of the product.

[0065] (3) The preparation method of the sunscreen lotion provided by the present invention has simple operation steps, low cost, and is easy to industrialize and mass produce. DETAILED DESCRIPTION

[0066] In order to further explain the technical means and effects adopted by the present invention, the technical solution of the present invention is further described below in conjunction with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0067] The following materials and comparative examples are as follows:

[0068]

[0069] The rest of the raw materials can be used as long as they are purchased from regular dealers.

[0070] Example 1

[0071] The present embodiment provides a composition for reducing the penetration of sunscreen into the skin. The composition for reducing the penetration of sunscreen into the skin comprises xanthan gum, ammonium acryloyldimethyltaurate / VP copolymer, HDI / trimethylolhexyllactone cross-linked polymer, and adipic acid / diethylene glycol / glycerol cross-linked polymer in a mass ratio of 1:5:10:5.

[0072] Example 2

[0073] This embodiment provides a composition for reducing the penetration of sunscreen into the skin. The composition for reducing the penetration of sunscreen into the skin is formulated with ammonium acryloyldimethyltaurate / VP copolymer and adipic acid / diethylene glycol / glycerol cross-linked polymer in a mass ratio of 1:3.

[0074] Example 3

[0075] This embodiment provides a composition for reducing the penetration of sunscreen into the skin. The composition for reducing the penetration of sunscreen into the skin is formulated with ammonium acryloyldimethyltaurate / VP copolymer, HDI / trimethylol hexyllactone cross-linked polymer, and adipic acid / diethylene glycol / glycerol cross-linked polymer in a mass ratio of 24:50:5.

[0076] Example 4

[0077] This embodiment provides a composition for reducing the penetration of sunscreen into the skin. The composition for reducing the penetration of sunscreen into the skin is different from that of Embodiment 1 only in that the formula does not include ammonium acryloyldimethyltaurate / VP copolymer, and the reduced amount is supplemented by xanthan gum. The remaining components and addition amounts are consistent with those of Embodiment 1. The preparation method refers to that of Embodiment 1.

[0078] Example 5

[0079] This embodiment provides a composition for reducing the penetration of sunscreen into the skin. The composition for reducing the penetration of sunscreen into the skin is different from that of Example 1 only in that xanthan gum is not included in the formula, and the reduced amount is supplemented by ammonium acryloyldimethyltaurate / VP copolymer. The remaining components and addition amounts are consistent with those of Example 1. The preparation method refers to Example 1.

[0080] Example 6

[0081] This embodiment provides a composition for reducing the penetration of sunscreen into the skin. The composition for reducing the penetration of sunscreen into the skin differs from that of Embodiment 1 only in that the formula does not include HDI / trimethylol hexyllactone cross-linked polymer, and the reduced amount is supplemented by adipic acid / diethylene glycol / glycerol cross-linked polymer. The remaining components and addition amounts are consistent with those of Embodiment 1. The preparation method refers to that of Embodiment 1.

[0082] Example 7

[0083] This embodiment provides a composition for reducing the penetration of sunscreen into the skin. The composition for reducing the penetration of sunscreen into the skin differs from that of Embodiment 1 only in that adipic acid / diethylene glycol / glycerol crosslinked polymer is not included in the formula, and the reduced amount is supplemented by HDI / trimethylol hexyllactone crosslinked polymer. The remaining components and addition amounts are consistent with those of Embodiment 1. The preparation method refers to that of Embodiment 1.

[0084] Comparative Example 1

[0085] This comparative example provides a composition for reducing the penetration of sunscreen into the skin. The composition for reducing the penetration of sunscreen into the skin differs from Example 1 only in that the components do not include a water-soluble suspending thickener (xanthan gum and ammonium acryloyldimethyltaurate / VP copolymer), and the reduced amount thereof is distributed to the HDI / trimethylol hexyllactone cross-linked polymer and the adipic acid / diethylene glycol / glycerol cross-linked polymer in proportion to the number of parts. The remaining components and addition amounts are consistent with those in Example 1, and the preparation method refers to Example 1.

[0086] Comparative Example 2

[0087] This comparative example provides a composition for reducing the penetration of sunscreen into the skin. The composition for reducing the penetration of sunscreen into the skin differs from Example 1 only in that the composition does not include an oil-soluble thickener (HDI / trimethylol hexyllactone cross-linked polymer and adipic acid / diethylene glycol / glycerol cross-linked polymer), and the reduced amount thereof is distributed to xanthan gum and ammonium acryloyldimethyltaurate / VP in proportion to the number of parts. The remaining components and addition amounts are consistent with those in Example 1, and the preparation method refers to Example 1.

[0088] Application Examples 1-3

[0089] This application example provides three kinds of sunscreen lotions. The formulas of the sunscreen lotions are shown in Table 1. The dosage units of each component in the table are all "parts".

[0090] Table 1

[0091]

[0092]

[0093] Preparation method:

[0094] (1) taking 10% of the total amount of deionized water, adding arginine to dissolve evenly, then adding phenylbenzimidazole sulfonic acid and stirring and mixing at 400 rpm for 15 minutes to obtain a premixed phase;

[0095] (2) Add water-soluble suspension thickener, HS-11P and INUTEC SL1 were mixed with the remaining deionized water at 80°C and 1000 rpm for 15 min to obtain an aqueous phase;

[0096] (3) mixing the oil-soluble thickener, MONTANOV 68 and isononyl isononanoate at 80° C. and 2000 rpm for 10 min to obtain an oil phase;

[0097] (4) adding the oil phase to the water phase, mixing and stirring at 75°C and 7000 rpm, and then cooling to 40°C;

[0098] (5) Continue to add the premixed phase, mix and stir at 800 rpm for 10 minutes to obtain the composition for reducing skin penetration of sunscreen.

[0099] Application Example 4-7

[0100] This application example provides four sunscreen lotions, the difference between the sunscreen lotions and application example 1 is that the composition for reducing the penetration of sunscreen into the skin is replaced with the composition for reducing the penetration of sunscreen into the skin of examples 4-7 in equal amounts, and the remaining components and addition amounts are consistent with those in example 1. The preparation method refers to application example 1.

[0101] Application Example 8

[0102] This application example provides a sunscreen lotion, which differs from application example 1 only in that the emulsifier does not include MONTANOV 68, and the reduced amount thereof is distributed according to the proportion of parts. In HS-11P and INUTEC SL1, the remaining components and addition amounts are consistent with those in Example 1, and the preparation method is referred to Application Example 1.

[0103] Application Example 9

[0104] This application example provides a sunscreen lotion, which differs from application example 1 only in that the emulsifier does not include HS-11P, the reduced amount thereof is distributed to MONTANOV 68 and INUTEC SL1 according to the proportion of parts, and the other components and addition amounts are consistent with those in Example 1. The preparation method refers to Application Example 1.

[0105] Application Example 10

[0106] This application example provides a sunscreen lotion, which differs from application example 1 only in that the emulsifier does not include INUTEC SL1, and its reduced amount is distributed to MONTANOV 68 and In HS-11P, the remaining components and addition amounts are consistent with those in Example 1, and the preparation method is referred to Application Example 1.

[0107] Application Example 11

[0108] This application example provides a sunscreen lotion. The difference between the sunscreen lotion and application example 1 is that the sunscreen agent is only phenylbenzimidazole sulfonic acid, and the total amount of the sunscreen agent remains unchanged. The remaining components and the addition amounts are consistent with those in Example 1. The preparation method refers to application example 1.

[0109] Application Example 12

[0110] This application example provides a sunscreen lotion. The difference between the sunscreen lotion and application example 1 is that the sunscreen agent is only octocrylene, and the total amount of the sunscreen agent remains unchanged. The other components and the addition amounts are consistent with those in Example 1. The preparation method refers to application example 1.

[0111] Comparative Application Example 1-2

[0112] This comparative application example provides two sunscreen lotions, the difference between the sunscreen lotions and application example 1 is that the composition for reducing the penetration of sunscreen into the skin is replaced by the composition for reducing the penetration of sunscreen into the skin of comparative examples 1-2 in equal amounts, and the remaining components and addition amounts are consistent with those in example 1. The preparation method refers to application example 1.

[0113] Comparative Application Example 3-4

[0114] This comparative application example provides two sunscreen lotions, the difference between the sunscreen lotions and application example 11 is that the composition for reducing the penetration of sunscreen into the skin is replaced by the composition for reducing the penetration of sunscreen into the skin of comparative examples 1-2 in equal amounts, and the remaining components and addition amounts are consistent with example 11, and the preparation method refers to application example 1.

[0115] Comparative Application Example 5-6

[0116] This comparative application example provides two sunscreen lotions, the difference between the sunscreen lotions and application example 12 is that the composition for reducing the penetration of sunscreen into the skin is replaced by the composition for reducing the penetration of sunscreen into the skin of comparative examples 1-2 in equal amounts, and the remaining components and addition amounts are consistent with example 12. The preparation method refers to application example 1.

[0117] Comparative Application Example 7

[0118] This comparative application example provides two sunscreen lotions, which differ from Application Example 1 only in that the components do not include a composition for reducing the penetration of sunscreen agents into the skin, and the reduced amount is supplemented by deionized water. The remaining components and addition amounts are consistent with those in Example 1, and the preparation method refers to Application Example 1.

[0119] Test Example 1: Stability Test

[0120] The stability test includes high temperature, low temperature and hot and cold cycle test. The samples provided in application examples 1-12 and comparative application examples 1-7 are placed at 48°C and -15°C for 6 months respectively, and the appearance of the products is regularly observed for abnormal phenomena such as turbidity and stratification. After the products are subjected to hot and cold cycle at -18°C / 25°C for 3 times, they are observed for abnormal phenomena such as turbidity and stratification. The test results are shown in Table 1.

[0121] Table 1

[0122]

[0123] It can be seen from the data in Table 1 that the sunscreen lotion provided by the present invention has excellent high and low temperature stability.

[0124] Test Example 2 In vitro transdermal test Test subjects: sunscreen lotions of Application Examples 1-12 of the present invention and Comparative Application Examples 1-7, and two commercially available sunscreen products.

[0125] Test method:

[0126] (1) Skin samples were obtained from the abdomen of pigs and stored at -20°C, wrapped in aluminum foil until use. Before the experiment, the skin samples were thawed at room temperature for about 10 minutes, and 3 cm × 3 cm skin slices were cut and washed to remove dirt and sebum. All pig skin samples were provided by Huilang Bio.

[0127] (2) A vertical Franz diffusion cell was used, with an effective diffusion area of ​​1.77 cm2 and a receiving cell volume of 18 mL. A rotor was placed in the receiving cell, and the treated pigskin was fixed on the Franz diffusion cell with the epidermis facing the dosing cell. 2 ml of sunscreen lotion was added to the dosing cell, and the receiving cell was filled with phosphate buffered saline (PBS) containing 2% Tween 80.

[0128] (3) Diffusion cell method: Place the Franz diffusion cell on the platform of the transdermal absorption tester, with the water temperature at 37°C and the rotation speed at 300 r / min. Alternatively, constant temperature water bath method: Place the Franz diffusion cell in a 37°C water bath with the skin above the water surface of the water bath.

[0129] (4) After 6 hours, the diffusion cell device was removed, the suckling pig skin was taken out, and a layer of stratum corneum was torn off with tape after wiping it clean. The pig skin was cut and soaked in an appropriate amount of methanol, and ultrasonically treated (power of 500 W, frequency of 40 kHz) for 30 minutes. An appropriate amount of extract was taken and filtered through a 0.45 μm microporous filter membrane. The filtrate was taken and the sunscreen content was determined, and the drug retention per unit area of ​​skin Q was calculated. The results are shown in Table 2

[0130] Table 2

[0131]

[0132]

[0133] The less the retention of sunscreen in the skin, the higher its safety. As can be seen from Table 2, from the comparison between Comparative Application Example 3 and Application Examples 1-3, it can be seen that the retention of sunscreen in the skin of the sunscreen lotion added with the composition of the present invention is significantly less, indicating that the composition provided by the present invention can well solve the problem of sunscreen penetrating the skin; from Comparative Application Examples 1-2, it can be seen that the water-soluble thickener and the oil-soluble thickener selected by the present invention have a synergistic effect, and the combination of the two can better reduce the retention of sunscreen in the skin. From Application Examples 8-10, it can be seen that the compound use of the emulsifier selected by the present invention also affects the transdermal penetration of the sunscreen.

[0134] In addition, it should be noted that when using the diffusion cell method for testing, the subcutaneous fluid is stirred, and the substances in the skin will be quickly carried away and diluted after penetrating into the liquid. Therefore, the substances in the liquid in contact with the skin are always at a lower concentration. The skin and liquid can always maintain a relatively high osmotic pressure. When the osmotic pressure is high, the ingredients will penetrate faster, so the values ​​detected using this method will be higher.

[0135] When the constant temperature water bath method is used for the test, the subcutaneous fluid is immobile. If any substance in the skin penetrates into the fluid, it can only diffuse slowly by molecular movement. The local area where the liquid contacts the skin has a relatively low osmotic pressure, so the penetration rate is slower than that of the diffusion cell method.

[0136] Test Example 3 Consumer Sensory Effect Evaluation

[0137] 90 female volunteers aged between 30 and 35 were selected as test subjects and randomly divided into 15 groups, with 6 people in each group. Test method: The test subjects used the products of application examples 1-10 and comparative application examples 1-3 and two commercially available sunscreen products, respectively, once a day in the morning for 15 consecutive days. After use, the test subjects scored the use effect using a 10-point system: 9 points or more means very good, very satisfied; 8-9 points are good; 7-8 points are moderately acceptable; and below 7 points are not good, unacceptable. The score of each group is the average of 6 people, and the results are shown in Table 3.

[0138] Table 3

[0139] sample Comfort Skin feel Application Example 1 9.67 9.77 Application Example 2 9.36 9.41 Application Example 3 9.32 9.27 Application Example 4 8.29 8.36 Application Example 5 8.69 8.79 Application Example 6 8.56 8.49 Application Example 7 8.68 8.77 Application Example 8 8.02 8.09 Application Example 9 7.89 7.95 Application Example 10 8.05 8.21 Application Example 11 9.02 8.94 Application Example 12 8.89 9.01 Comparative application example 1 5.56 5.49 Comparative Application Example 2 8.23 8.13 Comparative Application Example 3 5.16 5.16 Comparative Application Example 4 8.03 8.03 Comparative Application Example 5 5.56 5.36 Comparative Application Example 6 7.86 7.58 Comparative Application Example 7 3.14 3.14 Commercially available products 1 8.16 8.03 Commercially available product 2 8.33 8.42

[0140] It can be seen from Table 3 that the product of the present invention has a good use effect. Compared with the same type of products on the market, the sunscreen lotion involved in the present invention has more excellent soothing effect and skin feel.

[0141] Test Example 4

[0142] Safety evaluation:

[0143] The specific method is as follows: 40 females aged 18-35 years old with no history of allergies were selected, and each subject tried the product prepared in Application Examples 1-12. After cleaning the back of the subject, the spot tester with the sample was applied to the selected position on the back with a non-irritating tape. After pasting, it was lightly pressed with fingers to make it evenly attached to the skin for 24 hours. The subject kept the patch area dry within 24 hours, and avoided intense exercise, scratching the patch area, long-term sunlight exposure, etc. After 24 hours, the tester was removed and marked, and after 30 minutes, the indentation disappeared and the judgment was made under sufficient light.

[0144] The grading standards for adverse skin reactions are shown in Table 4:

[0145] Table 4

[0146]

[0147] The results are shown in Table 5:

[0148] Table 5

[0149]

[0150]

[0151] It can be seen from the data in Table 5 that all the subjects had negative reactions, which indicates that the sunscreen lotion of the present invention has no adverse reactions to the human body and is highly safe.

[0152] The applicant declares that the present invention uses the above-mentioned embodiments to illustrate a composition for reducing the penetration of sunscreen into the skin and its application, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of various raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0153] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.

[0154] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. A composition for reducing the penetration of sunscreen into the skin, characterized in that The composition for reducing the penetration of sunscreen into the skin comprises a water-soluble suspending thickener and an oil-soluble thickener; The mass ratio of the water-soluble suspension thickener to the oil-soluble thickener is (0.1-3):(0.1-6).

2. The composition for reducing sunscreen penetration through the skin according to claim 1, characterized in that The water-soluble suspension thickener includes any one or a combination of at least two of xanthan gum, acrylic acid (esters) / C10-30 alkyl acrylate cross-polymer, ammonium acryloyldimethyltaurate / VP copolymer, ammonium acryloyldimethyltaurate / behenyl alcohol polyether-25 methacrylate cross-polymer, polyacrylate cross-polymer-6, acrylic acid (esters) / vinyl isodecanoate cross-polymer or acrylic acid (esters) copolymer; Preferably, the water-soluble suspension thickener is a combination of xanthan gum and ammonium acryloyldimethyltaurate / VP copolymer; Preferably, the mass ratio of the xanthan gum to ammonium acryloyldimethyltaurate / VP copolymer is 1:(2-8).

3. The composition for reducing sunscreen penetration through the skin according to claim 1 or 2, characterized in that: The oil-soluble thickener includes any one or a combination of at least two of HDI / trimethylol hexyl lactone cross-linked polymer, adipic acid / diethylene glycol / glycerol cross-linked polymer, butene / ethylene / styrene copolymer, hydrogenated (styrene / isoprene) copolymer or hydrogenated (styrene / butadiene) copolymer; Preferably, the oil-soluble thickener is a combination of HDI / trimethylol hexyl lactone cross-linked polymer and adipic acid / diethylene glycol / glycerol cross-linked polymer; Preferably, the mass ratio of the HDI / trimethylol hexyl lactone cross-linked polymer to the adipic acid / diethylene glycol / glycerol cross-linked polymer is 1:(0.1-1).

4. Use of a composition for reducing skin penetration of sunscreen agents as claimed in any one of claims 1 to 3 in the preparation of sunscreen products; Preferably, the composition for reducing skin penetration of sunscreen agents has a mass percentage of 1-10% in the sunscreen product.

5. A sunscreen lotion, characterized in that: The components of the sunscreen lotion include, by weight, 1-10 parts of the composition for reducing skin penetration of sunscreen agents according to any one of claims 1-3, 5-15 parts of an oil solvent, 1-5 parts of an emulsifier, 5-20 parts of a sunscreen agent, and 10-90 parts of deionized water.

6. The sunscreen lotion according to claim 5, characterized in that The oil solvent includes isononyl isononanoate; Preferably, the emulsifier includes any one or a combination of at least two of cetearyl alcohol, cetearyl glucoside, sodium stearoyl glutamate, glycerin or inulin lauryl carbamate; Preferably, the emulsifier is a combination of cetearyl alcohol, cetearyl glucoside, sodium stearoyl glutamate, glycerin and inulin lauryl carbamate.

7. The sunscreen lotion according to claim 5 or 6, characterized in that: The sunscreen includes water-soluble sunscreen and / or oil-soluble sunscreen; Preferably, the water-soluble sunscreen agent comprises any one or a combination of at least two of phenylbenzimidazole sulfonic acid, methylene bis-benzotriazolyl tetramethylbutylphenol, benzylidene camphor sulfonic acid or PEG-25 p-aminobenzoic acid; Preferably, the oil-soluble sunscreen comprises any one of octocrylene, bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, ethylhexyl methoxycinnamate, ethylhexyl salicylate, diethylhexyl butyramido triazone or polysilicone-15, or a combination of at least two thereof; Preferably, the sunscreen lotion further comprises any one or a combination of at least two of a pH adjuster, a fragrance or a preservative; Preferably, the pH adjusting agent comprises arginine.

8. The method for preparing the sunscreen lotion according to any one of claims 5 to 7, characterized in that: The preparation method comprises the steps of stirring a composition for reducing the penetration of sunscreen into the skin, an oil solvent, an emulsifier and a sunscreen in deionized water to obtain the sunscreen emulsion.

9. The preparation method according to claim 8, characterized in that: The preparation method comprises: (1) stirring and mixing a water-soluble sunscreen agent in a portion of deionized water to obtain a premix phase; (2) mixing and stirring a water-soluble suspension thickener, sodium stearoyl glutamate, glycerin and inulin lauryl carbamate in the remaining deionized water to obtain an aqueous phase; (3) mixing and stirring an oil-soluble thickener, cetearyl alcohol, cetearyl glucoside, an oil solvent, and an oil-soluble sunscreen to obtain an oil phase; (4) adding the oil phase to the water phase, mixing and stirring, and then cooling; (5) Then add the premixed phase, mix and stir to obtain the sunscreen lotion.

10. The preparation method according to claim 9, characterized in that: The partial deionized water in step (1) is 5-15% of the total amount of deionized water; Preferably, the stirring speed in step (1) is 200-500 rpm and the time is 5-20 min; Preferably, the mixing and stirring in step (2) is performed at a speed of 500-1500 rpm; Preferably, the mixing and stirring in step (2) is performed at a temperature of 70-90° C. for 10-30 min. Preferably, the mixing and stirring in step (3) is performed at a speed of 1000-3000 rpm; Preferably, the mixing and stirring in step (3) is carried out at a temperature of 70-90° C. and for a time of 5-20 min; Preferably, the mixing and stirring in step (4) is performed at a speed of 5000-10000 rpm; Preferably, the mixing and stirring in step (4) is carried out at a temperature of 70-80° C. and for a time of 5-15 min; Preferably, the cooling temperature in step (4) is 40-45°C; Preferably, the mixing and stirring speed in step (5) is 300 rpm-1500 rpm, and the stirring time is 5-10 min.

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