Antibacterial product as well as preparation method and application thereof

Abstract

The invention relates to the technical field of bacteriostasis, in particular to a bacteriostatic product and a preparation method and application thereof. The antibacterial product comprises the following components in parts by weight: 0.05-1 part of potassium iodide; 0.05 to 1 part of potassium iodate; 0.5 to 10 parts of iodine; 6 to 60 parts of glycerol; 15 to 80 parts of AEO-9 (fatty alcohol polyoxyethylene ether); 0.5 to 5 parts of a sour regulator; and 1-10 parts of essential oil. The invention provides a multifunctional disinfectant, which contains iodine, potassium iodide, potassium iodate, glycerol, AEO-9, a pH regulator and essential oil, has strong bactericidal ability, is a broad-spectrum, safe and efficient disinfectant which can be produced in an expanded manner, and is not easy to dye, non-irritant to skin, good in stability and capable of deeply sterilizing.

Description

Technical Field

[0001] The present invention relates to the technical field of antibacterial products, and in particular to an antibacterial product and a preparation method and application thereof. Background Art

[0002] Common skin problems include eczema, itchy skin, athlete's foot, and difficult wound healing. Faced with such problems, we will use zinc oxide cream, calamine, etc. to eliminate eczema and itchy skin, but the effect is not obvious; for athlete's foot, broad-spectrum creams such as terbinafine hydrochloride cream, econazole nitrate cream, and ketoconazole cream are generally used, which take 5-7 days to use and are easy to relapse; alcohol and iodine are often used for wound healing, but the disinfection effect is poor. A composite iodine disinfectant and its preparation method and application are mentioned in CN 115844967A. The patent involves Chinese medicine components and chemical components, and the synergy of the two can improve the disinfection effect. Chinese medicine components are complex, and iodine is an oxidant, which can easily destroy the components in Chinese medicine and reduce the bactericidal effect of the product. Patent CN116549717A mentions adding tannic acid to increase product stability and accelerate wound healing. The stability of tannic acid is greatly affected by pH and can be converted into gallic acid at different pH levels. This brings uncertainty to product production and stability, and the efficacy cannot be fully guaranteed. Summary of the invention

[0003] In view of the problems existing in the prior art, the first aspect of the present invention provides an antibacterial product, which comprises, by weight:

[0004]

[0005] The iodine in the present invention can oxidize the active groups of the cell protoplasmic protein and combine with the amino group, thereby denaturing the pathogen amino acid and enzyme and achieving the purpose of sterilization. The essential oil in the present invention contains alcohol and phenol components, which have antibacterial and antibacterial effects. Iodine is toxic and corrosive. After adding specific essential oils, the sterilization effect is improved and the amount of iodine used can be reduced.

[0006] Preferably, the composition comprises, by weight:

[0007]

[0008]

[0009] The addition of potassium iodide in the present invention can reduce the decomposition of elemental iodine, increase the solubility of elemental iodine, and also has a certain disinfection effect.

[0010] AEO-9 in the present invention refers to fatty alcohol polyoxyethylene ether, and its CAS number is 68131-39-5.

[0011] Preferably, A1) the sourness regulator is selected from one or more of citric acid, malic acid and tartaric acid;

[0012] Preferably, A2) the essential oil comprises a first essential oil and a second essential oil.

[0013] Preferably, the molecular formula of the fatty alcohol polyoxyethylene ether described in A3) is C 30 H 62 O 10 The higher the addition number of ethylene oxide in this substance, the easier it is to dissolve in water, and the smaller the addition number, the easier it is to dissolve in oils and fats. The addition number of ethylene oxide in the present invention is 9, which is the best effect in all tests.

[0014] Preferably, in feature A2), the first essential oil is selected from one or more of honeysuckle, eucalyptus and tea tree. The honeysuckle in the present invention contains rich chlorogenic acid, which can play an antibacterial, anti-inflammatory and antiviral role. The eucalyptus in the present invention has a strong bactericidal effect and also has the effect of reducing the viscosity of mucus in the body; the tea tree in the present invention has the effects of detoxification, antibacterial, hypoglycemic and enhancing immunity.

[0015] Preferably, in feature A2), the second essential oil is selected from one or more of rose essential oil, lavender essential oil, chamomile essential oil, and rosemary essential oil.

[0016] Preferably, in feature A2), the antibacterial product comprises 0.5 to 6 parts by weight of the first essential oil:

[0017] And / or, in feature A2), the antibacterial product comprises 0.5 to 3 parts of the second essential oil by weight.

[0018] The second aspect of the present invention provides an application of an antibacterial product, wherein the antibacterial product is applied to one or more of eczema, skin itching, athlete's foot, wounds, gynecological diseases, hemorrhoids, and anal redness and swelling.

[0019] The third aspect of the present invention provides a disinfectant comprising the above-mentioned antibacterial product.

[0020] The fourth aspect of the present invention provides a method for preparing the above-mentioned antibacterial product, comprising the following steps:

[0021] 1) mixing potassium iodide, potassium iodate, iodine, glycerin and part of AEO-9 to obtain a first mixture, and mixing essential oil and the remaining part of AEO-9 to obtain a second mixture;

[0022] 2) adding a solvent to the first mixture obtained in step 1) to adjust the volume, and adding a sourness regulator to adjust the pH to obtain a third mixture;

[0023] 3) The second mixture obtained in step 1) is mixed with the third mixture obtained in step 2), and the volume is fixed to obtain the antibacterial product.

[0024] Mixing potassium iodide, potassium iodate, iodine, glycerin and part of AEO-9 can dissolve the iodine source to the greatest extent first, making it difficult to precipitate, thereby ensuring the stability of the product; mixing the essential oil with the remaining part of AEO-9 can prevent the effective ingredients of the essential oil from being oxidized by iodine first, thereby losing the meaning of the complex synergistic effect.

[0025] The standard for volume determination in the present invention is that the concentration of iodine in step 2) is between 6 and 9 thousandths, and the concentration of iodine in the final volume determination product is between 4.5 and 5.5 thousandths.

[0026] Preferably, in step 11), the mass ratio of the first use of AEO-9 to the second use of AEO-9 is 1.5 to 3:1; in the present invention, when the ratio of the first use of AEO-9: the second use of AEO-9 is lower than 1.5, the solubility of iodine will be poor and it will be easy to precipitate in the final product; when the ratio of the first use of AEO-9: the second use of AEO-9 is greater than 3, the effective ingredients in the essential oil cannot be well emulsified and protected, which will reduce the effectiveness of the effective ingredients.

[0027] Preferably, in step 21), the solvent is water;

[0028] Preferably, in step 22), the pH is 4.8 to 5.5, for example, 4.8 to 4.9, 4.9 to 5.0, 5.0 to 5.1, 5.1 to 5.2, 5.2 to 5.3, 5.3 to 5.4, and 5.4 to 5.5. In the present invention, a pH of 4.8 to 5.5 is conducive to the stability of iodine, but too low a pH may easily cause skin irritation. When the pH is lower than 4.8, sensitive skin may feel irritation; when the pH is too high, iodine is easily precipitated, and the active ingredients in the essential oil are easily decomposed and destroyed.

[0029] The present invention has the following beneficial effects:

[0030] 1) The present invention provides a multifunctional disinfectant, which contains iodine, potassium iodide, potassium iodate, glycerol, fatty alcohol polyoxyethylene ether (AEO-9), pH regulator, and essential oil. The invention has a strong bactericidal ability and is a broad-spectrum, safe, efficient, and scalable disinfectant. It is not easy to stain, has no irritation to the skin, has good stability, and can kill bacteria in deep layers.

[0031] 2) The invented product not only acts on skin diseases but also can treat gynecological diseases, hemorrhoids, anal redness and swelling, etc.;

[0032] 3) The preparation method of the antibacterial product of the present invention is simple and low in cost. DETAILED DESCRIPTION

[0033] The following is a description of the implementation of the present invention by means of specific embodiments. Those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification.

[0034] It should be noted that the structures, proportions, sizes, etc. described in this specification are only used to match the contents disclosed in the specification for people familiar with this technology to understand and read, and are not used to limit the limiting conditions for the implementation of the present invention, so they have no substantial technical significance. Any modification of the structure, change in the proportion relationship, or adjustment of the size should still fall within the scope of the technical content disclosed by the present invention without affecting the effects and purposes that can be achieved by the present invention. At the same time, the terms such as "upper", "lower", "left", "right", "middle" and "one" quoted in this specification are only for the convenience of description, and are not used to limit the scope of the implementation of the present invention. The change or adjustment of their relative relationship should also be regarded as the scope of the implementation of the present invention without substantially changing the technical content.

[0035] Example 1

[0036] An antibacterial product is composed as follows:

[0037]

[0038] Preparation method:

[0039] 1) iodine, potassium iodide, potassium iodate, glycerin and 40 parts of AEO-9 were weighed according to the prescription, and stirred to dissolve to obtain a first mixture; honeysuckle essential oil, eucalyptus essential oil and rose essential oil and 20 parts of AEO-9 were weighed, and stirred to dissolve to obtain a third mixture;

[0040] 2) adding water to the first mixture obtained in step 1) and stirring until the volume is about 500 mL, and adding citric acid to adjust the pH of the solution to 5.0, to obtain a third mixture;

[0041] 3) mixing the second mixture obtained in step 1) and the third mixture obtained in step 2) and stirring them, and then fixing the volume to 1000 mL;

[0042] 4) The antibacterial product obtained in step 3) is stirred evenly and filled as needed.

[0043] Comparative Example 1-1

[0044] The specific composition is as follows:

[0045]

[0046]

[0047] Preparation method:

[0048] 1) Weigh iodine, potassium iodide, potassium iodate, glycerol and AEO-9 according to the prescription, stir to dissolve, and then dilute with water until about 500 mL;

[0049] 2) Adjust the pH of the solution with citric acid to 5.0;

[0050] 3) Add water to make the volume of step 3) to 1000 mL;

[0051] 4) Stir the mixture obtained in step 4) evenly and fill it as needed.

[0052] Comparative Example 1-2

[0053] The specific composition is as follows:

[0054]

[0055] Preparation method:

[0056] 1) Weigh glycerin, AEO-9, honeysuckle essential oil, eucalyptus essential oil, and rose essential oil according to the prescription, stir to dissolve, and then dilute with water to about 500 mL;

[0057] 2) Adjust the pH of the solution with citric acid to 5.0;

[0058] 3) Add water to the mixture obtained in step 2) to make the volume to 1000 mL;

[0059] 4) Stir the mixture obtained in step 3) evenly and fill it as needed.

[0060] Example 2

[0061] An antibacterial product is composed as follows:

[0062]

[0063] Preparation method:

[0064] 1) weighing iodine, potassium iodide, potassium iodate, glycerin and 50 parts of AEO-9 according to the prescription, and stirring and dissolving them to obtain a first mixture; weighing honeysuckle essential oil, tea tree essential oil, lavender essential oil and 20 parts of AEO-9, and stirring and dissolving them to obtain a second mixture;

[0065] 2) adding water to the first mixture obtained in step 1) and stirring until the volume is about 500 mL, and adding tartaric acid to adjust the pH of the solution to 5.2, to obtain a third mixture;

[0066] 3) mixing the second mixture obtained in step 1) and the third mixture obtained in step 2) and stirring them, and then fixing the volume to 1000 mL;

[0067] 4) The antibacterial product obtained in step 3) is stirred evenly and filled as needed.

[0068] Comparative Example 2-1

[0069] The specific composition is as follows:

[0070]

[0071] Preparation method:

[0072] 1) Weigh iodine, potassium iodide, potassium iodate, glycerol and AEO-9 according to the prescription, stir to dissolve, and then dilute with water until about 500 mL;

[0073] 2) adjusting the pH of the solution with tartaric acid to a pH of 5.2;

[0074] 3) Add water to the mixture obtained in step 2) to make the volume to 1000 mL;

[0075] 4) Stir the mixture obtained in step 3) evenly and fill it as needed.

[0076] Comparative Example 2-2

[0077] The specific composition is as follows:

[0078]

[0079] 1) Weigh glycerin, AEO-9, honeysuckle essential oil, tea tree essential oil, and lavender essential oil according to the prescription, stir to dissolve, and then dilute with water to about 500 mL;

[0080] 2) adjusting the pH of the solution with tartaric acid to a pH of 5.2;

[0081] 3) adding water to the mixture obtained in step 2) to make the volume to 1000 mL;

[0082] 4) Stir the mixture after volume adjustment in step 3) evenly and fill it as needed.

[0083] Example 3

[0084] Performance Testing

[0085] 1) Test purpose: To test the skin irritation of the product

[0086] 2) Test method:

[0087] Hygienic Standards for Cosmetics 2007;

[0088] Testing environment: Ordinary animal room, license number: SYXK(Shanghai)2014-0020, room temperature 18-23℃; relative humidity: 45-65%;

[0089] Experimental animals: New Zealand white rabbits, weighing 2.88-3.13 kg, provided by Shanghai Keshuo Experimental Animal Co., Ltd., license number SCXK (Shanghai);

[0090] Number of animals / sex: 4 animals / group, regardless of gender;

[0091] Observation time: 1, 24, 48, 72 h after removing auxiliary materials;

[0092] Test method: Take 0.5g sample and apply it directly to the test part. Use closed test. Remove the auxiliary material after 4 hours, wash the contact part with warm water, and observe and record the time.

[0093] 3) Samples: Example 1, Comparative Example 1-1, Comparative Example 1-2, Example 2, Comparative Example 2-1, Comparative Example 2-2, and commercially available iodine tincture;

[0094] 4) Test results

[0095] Skin irritation intensity classification

[0096] Skin irritation index Stimulus intensity 0～＜0.5 Non-irritating 0.5～＜2.0 Mild irritation 2.0～＜6.0 Moderate irritation 6.0～＜8.0 Strong irritation

[0097] Skin test results

[0098]

[0099] 5) Test conclusion: According to the skin irritation intensity classification, the 4 samples are non-irritating to rabbit skin, and the commercially available iodine tincture is slightly irritating. As time goes by, the irritation phenomenon disappears.

[0100] Example 4

[0101] Antibacterial test

[0102] 1) Test purpose: to conduct antibacterial test on the product

[0103] 2) Test method:

[0104] WS / T 650-2019 Antibacterial and antibacterial effect evaluation method 5.1.1 Suspension quantitative antibacterial test;

[0105] Detected bacteria: Staphylococcus aureus ATCC6538, Candida albicans ATCC10231; 3) Test sample: 10% Example 1; 10% Comparative Example 1; 10% Comparative Example 1-1

[0106] 4) Test results

[0107] 10% Example 1

[0108]

[0109] 10% Comparative Example 1-1

[0110]

[0111] 10% Comparative Example 1-2

[0112]

[0113]

[0114] 5) Test conclusion

[0115]

[0116] From the above, it can be seen that 10% Example 1 has a strong antibacterial effect, 10% Example 1 has an antibacterial effect on Staphylococcus aureus, but has no antibacterial effect on Candida albicans, and 10% Comparative Example 1-2 has a uniform antibacterial effect on Staphylococcus aureus and Candida albicans; the antibacterial effect of Example 1 is significantly better than that of Comparative Example 1-1 and Comparative Example 1-2, that is, the antibacterial effect after adding essential oil is significantly better than that of products without essential oil addition and pure essential oil products.

[0117] Example 5

[0118] Clinical Research:

[0119] Clinical subjects: 60 patients with hand pruritus were randomly selected, including 42 males and 18 females; they were divided into 3 groups, with 14 males and 6 females in each group;

[0120] Test samples: Example 2, Comparative Example 2, Comparative Example 2-2;

[0121] Test method: Wipe the itchy area with the sample once in the morning, noon and evening for 2 consecutive days;

[0122] Evaluation method: Effective: the itching symptoms disappeared, there was no irritation, and no color residue; Ineffective: the symptoms did not disappear, and there was still itching;

[0123] The statistical results are as follows:

[0124] Group Number of people Effective number of people Invalid number of people Effective proportion Example 2 20 19 1 95％ Comparative Example 2-1 20 10 10 50％ Comparative Example 2-2 20 2 18 10％

[0125] From the above, it can be concluded that the effect of Example 2 in solving hand itching is better than that of Comparative Example 2-1, and the effect of Comparative Example 2-1 is better than that of Comparative Example 2-2;

[0126] Participants reported that their hands did not feel any irritation and no color residue during use of Example 2, and the use effect was good.

[0127] The above description is only a preferred embodiment of the present invention, and is not any formal or substantial limitation of the present invention. It should be pointed out that ordinary technicians in this technical field can make several improvements and supplements without departing from the method of the present invention, and these improvements and supplements should also be regarded as the protection scope of the present invention. Any technician familiar with this profession, without departing from the spirit and scope of the present invention, can make some changes, modifications and equivalent changes made by using the technical content disclosed above, which are equivalent embodiments of the present invention; at the same time, any changes, modifications and evolutions of any equivalent changes made to the above embodiments based on the essential technology of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. An antibacterial product, characterized in that: In parts by weight:

2. The antibacterial product according to claim 1, characterized in that: In parts by weight:

3. The antibacterial product according to claim 1 or 2, characterized in that: Include at least one of the following technical features: A1) the acidity regulator is selected from one or more of citric acid, malic acid and tartaric acid; A2) the essential oil comprises a first essential oil and a second essential oil; A3) The molecular formula of the fatty alcohol polyoxyethylene ether is C 30 H 62 O 10 .

4. The antibacterial product according to claim 3, characterized in that: In feature A2), the first essential oil is selected from one or more of honeysuckle, eucalyptus and tea tree.

5. The antibacterial product according to claim 3, characterized in that: In feature A2), the second essential oil is selected from one or more of rose essential oil, lavender essential oil, chamomile essential oil, and rosemary essential oil.

6. The antibacterial product according to claim 3, characterized in that: In feature A2), the antibacterial product comprises 0.5 to 6 parts by weight of the first essential oil; And / or, in feature A2), the antibacterial product comprises 0.5 to 3 parts of the second essential oil by weight.

7. An application of an antibacterial product, characterized in that: The antibacterial product according to any one of claims 1 to 6 is applied to one or more of the drugs for treating eczema, skin itching, athlete's foot, wounds, gynecological diseases, hemorrhoids, and anal redness and swelling.

8. A disinfectant, characterized in that: The invention comprises the antibacterial product according to any one of claims 1 to 6.

9. The method for preparing the antibacterial product according to any one of claims 1 to 6, characterized in that: The following steps are involved: 1) mixing potassium iodide, potassium iodate, iodine, glycerin and part of AEO-9 to obtain a first mixture, and mixing essential oil and the remaining part of AEO-9 to obtain a second mixture; 2) adding a solvent to the first mixture obtained in step 1) to adjust the volume, and adding a sourness regulator to adjust the pH to obtain a third mixture; 3) The second mixture obtained in step 1) is mixed with the third mixture obtained in step 2), and the volume is fixed to obtain the antibacterial product.

10. The method for preparing the antibacterial product according to claim 9, characterized in that: Include at least one of the following technical features: 11) In step 1), the mass ratio of the first-use AEO-9 to the second-use AEO-9 is 1.5 to 3:1; 21) In step 2), the solvent is water; 22) In step 2), the pH is 4.8 to 5.5.

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