External medicinal oil for treating burn and preparation method thereof

Abstract

The invention discloses external medicinal oil for treating burn and a preparation method thereof. The external medicinal oil is prepared from the following raw materials: radix angelicae, radix scrophulariae, radix rehmanniae, angelica sinensis, golden cypress, cortex moutan, safflower, borneol, coptis chinensis, polygonum cuspidatum and pseudo-ginseng. The preparation method comprises the following steps: strictly disinfecting equipment and appliances in an ISO < 2 >-grade clean workshop, drying the raw materials at 60 DEG C, crushing, alternately soaking at 90 DEG C and 25 DEG C, stirring, filtering, adding the VE oil, filling sterile gauze, injecting edible oil, sealing, disinfecting, labeling and boxing. The medicine has remarkable advantages, the raw materials are precisely matched according to traditional Chinese medicine, and multiple formulas are flexibly selected; the preparation process is sterile, and the components can be fully extracted; clinical practice treatment of burns is painless, skin grafting is not needed, wound repair is good, and multiple functions are achieved. Toxicological tests are safe, and bacteriostasis and sterilization are achieved; the traditional Chinese medicine is wide in application range, suitable for various diseases such as burn, scald and trauma, safe, effective and practical, and wide in prospect.

Description

Technical Field

[0001] The invention relates to an external medicinal oil for treating burns and a preparation method thereof. Background Art

[0002] Burns, as a common and serious type of trauma, have always been a difficult problem in clinical treatment. In the field of traditional burn treatment, existing treatment methods have many limitations.

[0003] Existing burn drugs lack precise compatibility based on traditional Chinese medicine theory in terms of drug treatment. For example, some drugs only focus on one aspect of anti-infection or promoting wound healing, and fail to comprehensively consider the synergistic effects of multiple Chinese medicinal materials. They may only contain one or two herbs with a single effect, and cannot comprehensively target the complex pathological changes after burns, such as heat and toxic accumulation, blood stasis, damaged vital energy, and metabolic disorders, resulting in poor treatment effects, slow wound repair and easy scarring, and cannot effectively promote the regeneration and repair of burn wounds. Moreover, the raw material formulas of existing burn drugs often lack flexibility, do not take into account the different degrees of burns and individual differences among patients, and usually adopt a fixed formula combination, which is difficult to meet diverse clinical needs.

[0004] In terms of preparation technology, many production sites cannot meet the high standards of sterile environment requirements. For example, the clean workshop level is low, the equipment and instruments are not thoroughly disinfected, and microbial contamination cannot be eliminated from the source. This makes it difficult to ensure the quality of the prepared drugs and increases the risk of infection during patient use. At the same time, in the raw material processing link, there may be problems such as excessive drying temperature destroying the active ingredients, or improper extraction methods leading to insufficient extraction of the active ingredients.

[0005] In terms of drug performance, traditional burn drugs often cannot achieve painless treatment. Patients often need to endure great pain, and in many cases need skin grafting surgery, which not only brings physical trauma and mental stress to patients, but also creates a heavy economic burden. In addition, some drugs have a single function and can only relieve surface symptoms. They cannot simultaneously have multiple functions such as cooling blood and detoxifying, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, removing rot and promoting new growth, etc., which makes it difficult to fundamentally improve the condition of burns, and is prone to complications and prolonging recovery time. Moreover, in terms of safety, some drugs have problems such as irritation and sensitization, which have adverse effects on the patient's body, such as causing allergic reactions such as local skin redness, swelling, itching, and even damage to liver and kidney function. At the same time, their antibacterial and bactericidal abilities are limited, and they cannot effectively prevent and control wound infection, which seriously affects the treatment effect and patient safety.

[0006] In summary, the existing burn treatment drugs and methods have many defects, and it is necessary to study a new, safe, effective, practical and widely applicable burn treatment drug. The topical medicated oil for treating burns of the present invention is developed to solve these problems. Summary of the invention

[0007] The purpose of the present invention is to provide an external medicinal oil for treating burns and a preparation method thereof, so as to solve the problems raised in the above-mentioned background technology.

[0008] To solve the above technical problems, the technical solution provided by the present invention is: an external medicinal oil for treating burns, which is made from the following raw materials in parts by weight: 8-12 parts of Angelica dahurica, 12-18 parts of Scrophularia ningpoensis, 12-18 parts of Rehmannia glutinosa, 8-12 parts of Angelica sinensis, 8-12 parts of Phellodendron chinense, 12-18 parts of Moutan bark, 8-12 parts of Carthamus tinctorius, 8-12 parts of Borneolum, 4-6 parts of Coptis chinensis, 8-12 parts of Polygonum cuspidatum, and 8-12 parts of Panax notoginseng.

[0009] Preferably, the invention is made from the following raw materials in parts by weight: 10 parts of Angelica dahurica, 15 parts of Scrophularia ningpoensis, 15 parts of Rehmannia glutinosa, 10 parts of Angelica sinensis, 10 parts of Phellodendron chinense, 15 parts of Moutan bark, 10 parts of Carthamus tinctorius, 10 parts of Borneolum, 5 parts of Coptis chinensis, 10 parts of Polygonum cuspidatum, and 10 parts of Panax notoginseng.

[0010] Preferably, the invention is made from the following raw materials in parts by weight: 12 parts of Angelica dahurica, 12 parts of Scrophularia ningpoensis, 18 parts of Rehmannia glutinosa, 8 parts of Angelica sinensis, 12 parts of Phellodendron chinense, 12 parts of Moutan bark, 12 parts of Carthamus tinctorius, 8 parts of Borneolum, 6 parts of Coptis chinensis, 8 parts of Polygonum cuspidatum, and 12 parts of Panax notoginseng.

[0011] Preferably, the invention is made from the following raw materials in parts by weight: 8 parts of Angelica dahurica, 18 parts of Scrophularia ningpoensis, 12 parts of Rehmannia glutinosa, 12 parts of Angelica sinensis, 8 parts of Phellodendron chinense, 18 parts of Moutan bark, 8 parts of Carthamus tinctorius, 12 parts of Borneolum, 4 parts of Coptis chinensis, 12 parts of Polygonum cuspidatum, and 8 parts of Panax notoginseng.

[0012] A method for preparing an external medicinal oil for treating burns comprises the following steps:

[0013] 1) Equipment and auxiliary materials preparation: clean workshop ISO2 level; drying equipment, thermal disinfection; immersion equipment, thermal disinfection; filtering device, ultraviolet disinfection; heating equipment, thermal disinfection; disinfection equipment steam disinfection; device equipment, ultraviolet disinfection; isolation equipment, disinfection products; conveying equipment, ultraviolet disinfection; weighing equipment, compulsory inspection label; ion water cleaning / drying disinfection of sub-packaging glass bottles; prepare aluminum glass bottle caps, medical sterile gauze, standard edible oil, VE oil;

[0014] 2) Select raw materials and remove those with mildew, dampness, insects, impurities, or ash: Angelica dahurica, Scrophularia ningpoensis, Radix Rehmanniae, Angelica sinensis, Phellodendron chinense, Cortex Moutan, Carthamus tinctorius, Borneolum, Coptis chinensis, Polygonum cuspidatum, and Panax notoginseng;

[0015] 3) Dry the raw material at 58-62°C for 2 hours;

[0016] 4) Crush the dried raw materials to a size of 0.5-1.5 mm in diameter;

[0017] 5) Put the crushed raw materials into clean water and heat them to 88-92℃ for 2h;

[0018] 6) Soak at 22-28℃ for 48h;

[0019] 7) Stir once every 12 hours;

[0020] 8) Heat to 90℃ and soak for 2h;

[0021] 9) Soak at room temperature 25℃ for 48h;

[0022] 10) Stir once every 12 hours;

[0023] 11) Let stand for 4-6 hours;

[0024] 12) Filter with filter paper at 120℃-150℃;

[0025] 13) Add VE oil and stir evenly;

[0026] 14) Each bottle is rotated and filled with 40-60g sterilized gauze;

[0027] 15) Inject 25-35ml of standard edible oil and seal immediately;

[0028] 16) Place the plate in a sterilizer and sterilize with circulating steam for 28-32 minutes;

[0029] 17) Label and pack.

[0030] Preferably, in step 3), the raw material is dried at 60° C. for 2 hours.

[0031] Preferably, the crushing standard in step 4) is 1 mm.

[0032] Preferably, the step 11) is left to stand for 5 hours.

[0033] Preferably, 5*10 cm sterile gauze is used in step 14).

[0034] Preferably, 30 ml of standard edible oil is injected in step 15).

[0035] The advantages of the present invention are: in terms of raw material formula, more than a dozen natural Chinese medicinal materials such as Angelica dahurica, Scrophularia ningpoensis, and Angelica sinensis are accurately combined according to the theory of traditional Chinese medicine, and the effects of each medicine complement each other, such as Angelica dahurica reducing swelling and pus discharge, and Angelica sinensis promoting blood circulation and removing blood stasis, etc., which work together on the pathological mechanism of burns, promote wound regeneration and repair, and improve the treatment effect. At the same time, a variety of preferred raw material weight formulas are provided, which can be flexibly selected according to the degree of burns and individual differences of patients, enhance the adaptability and pertinence of the medicine, and provide more solutions for clinical treatment.

[0036] In terms of preparation technology, in the clean workshop ISO2 environment, all equipment and instruments are sterilized by heat, steam, ultraviolet and other methods, strictly aseptic operation is carried out to prevent microbial contamination, ensure the quality and safety of the drug oil, and reduce the risk of infection for patients. After the raw materials are dried at 60℃ for 2 hours and broken into 1mm, they are fully extracted by alternating 90℃ hot soaking and 25℃ cold soaking with regular stirring, and then filtered through 120℃-150℃ filter paper, and VE oil is added, which not only stabilizes the ingredients and prolongs the shelf life, but also synergistically improves the efficacy of the drug.

[0037] The drug has outstanding performance advantages. It can treat burns without pain and does not require skin grafting, which reduces the pain and economic burden of patients. The wound surface is well repaired, and the new skin is soft, smooth and scar-free, which improves the quality of life of patients. It has multiple functions such as cooling blood and detoxifying, promoting blood circulation and removing blood stasis, which can improve the condition, reduce complications and accelerate recovery in many aspects. Toxicology tests have proved that it is non-irritating, non-sensitizing, has no adverse effects on the body, and has antibacterial and bactericidal effects on a variety of bacteria, effectively preventing and controlling wound infection, and ensuring treatment effects and patient safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Figure 1 It is a process flow chart of the present invention. DETAILED DESCRIPTION

[0039] For the purpose of the following detailed description, it should be understood that the present invention may adopt various alternative changes and step sequences, unless expressly specified to the contrary. In addition, except in any operating examples, or otherwise indicated, all numbers representing the amount of ingredients used in the specification and claims should be understood to be modified by the term "about" in all cases. Therefore, unless otherwise indicated, the numerical parameters set forth in the following specification and the attached claims are approximate values ​​that vary according to the desired performance to be obtained by the present invention. At least it is not intended to limit the application of the doctrine of equivalents to the scope of the claims, and each numerical parameter should at least be interpreted according to the number of reported significant figures and by applying ordinary rounding techniques.

[0040] Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values ​​set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements.

[0041] In addition, it should be understood that any numerical range described herein is intended to include all subranges subsumed therein. For example, a range of "1 to 10" is intended to include all subranges between (and including) the stated minimum value of 1 and the stated maximum value of 10, i.e., having a minimum value equal to or greater than 1 and a maximum value equal to or less than 10.

[0042] Example 1

[0043] A topical medicinal oil for treating burns is prepared from the following raw materials in parts by weight: 10 parts of angelica dahurica, 15 parts of Scrophularia ningpoensis, 15 parts of Radix Rehmanniae, 10 parts of Angelica sinensis, 10 parts of Phellodendron chinense, 15 parts of Cortex Moutan, 10 parts of Carthamus tinctorius, 10 parts of Borneolum, 5 parts of Coptis chinensis, 10 parts of Polygonum cuspidatum, and 10 parts of Notoginseng.

[0044] A method for preparing an external medicinal oil for treating burns comprises the following steps:

[0045] 1) Equipment and auxiliary materials preparation: clean workshop ISO2 level; drying equipment, thermal disinfection; immersion equipment, thermal disinfection; filtering device, ultraviolet disinfection; heating equipment, thermal disinfection; disinfection equipment steam disinfection; device equipment, ultraviolet disinfection; isolation equipment, disinfection products; conveying equipment, ultraviolet disinfection; weighing equipment, compulsory inspection label; ion water cleaning / drying disinfection of sub-packaging glass bottles; prepare aluminum glass bottle caps, medical sterile gauze, standard edible oil, VE oil;

[0046] 2) Select raw materials and remove those with mildew, dampness, insects, impurities, or ash: Angelica dahurica, Scrophularia ningpoensis, Radix Rehmanniae, Angelica sinensis, Phellodendron chinense, Cortex Moutan, Carthamus tinctorius, Borneolum, Coptis chinensis, Polygonum cuspidatum, and Panax notoginseng;

[0047] 3) Dry the raw materials at 60°C for 2 hours;

[0048] 4) Crush the dried raw materials to a size of 1 mm in diameter;

[0049] 5) Put the crushed raw materials into clean water and heat them to 90℃ for 2h;

[0050] 6) Soak at 25℃ for 48h;

[0051] 7) Stir once every 12 hours;

[0052] 8) Heat to 90℃ and soak for 2h;

[0053] 9) Soak at room temperature 25℃ for 48h;

[0054] 10) Stir once every 12 hours;

[0055] 11) Let stand for 5 hours;

[0056] 12) Filter with filter paper at 140℃;

[0057] 13) Add VE oil and stir evenly;

[0058] 14) Each bottle is rotated and loaded with 50g sterilized gauze to facilitate the adhesion of the drug oil;

[0059] 15) Pour 30ml of standard edible oil and seal immediately;

[0060] 16) Place the plate in a sterilizer and sterilize with circulating steam for 30 minutes;

[0061] 17) Label and pack.

[0062] Preferably, 5*10 cm sterile gauze is used in step 14).

[0063] Example 2

[0064] A topical medicinal oil for treating burns is prepared from the following raw materials in parts by weight: 12 parts of angelica dahurica, 12 parts of Scrophularia ningpoensis, 18 parts of Radix Rehmanniae, 8 parts of Angelica sinensis, 12 parts of Phellodendron chinense, 12 parts of Cortex Moutan, 12 parts of Carthamus tinctorius, 8 parts of Borneolum, 6 parts of Coptis chinensis, 8 parts of Polygonum cuspidatum, and 12 parts of Notoginseng.

[0065] A method for preparing an external medicinal oil for treating burns comprises the following steps:

[0066] 1) Equipment and auxiliary materials preparation: clean workshop ISO2 level; drying equipment, thermal disinfection; immersion equipment, thermal disinfection; filtering device, ultraviolet disinfection; heating equipment, thermal disinfection; disinfection equipment steam disinfection; device equipment, ultraviolet disinfection; isolation equipment, disinfection products; conveying equipment, ultraviolet disinfection; weighing equipment, compulsory inspection label; ion water cleaning / drying disinfection of sub-packaging glass bottles; prepare aluminum glass bottle caps, medical sterile gauze, standard edible oil, VE oil;

[0067] 2) Select raw materials and remove those with mildew, dampness, insects, impurities, or ash: Angelica dahurica, Scrophularia ningpoensis, Radix Rehmanniae, Angelica sinensis, Phellodendron chinense, Cortex Moutan, Carthamus tinctorius, Borneolum, Coptis chinensis, Polygonum cuspidatum, and Panax notoginseng;

[0068] 3) Dry the raw material at 58°C for 2 hours;

[0069] 4) Crush the dried raw materials to a size of 1 mm in diameter;

[0070] 5) Put the crushed raw materials into clean water and heat them to 92℃ for 2h;

[0071] 6) Soak at 22℃ for 48h;

[0072] 7) Stir once every 12 hours;

[0073] 8) Heat to 90℃ and soak for 2h;

[0074] 9) Soak at room temperature 25℃ for 48h;

[0075] 10) Stir once every 12 hours;

[0076] 11) Let stand for 6 hours;

[0077] 12) Filter with filter paper at 150℃;

[0078] 13) Add VE oil and stir evenly;

[0079] 14) Each bottle is rotated and filled with 40g sterile gauze;

[0080] 15) Pour 35 ml of standard edible oil and seal immediately;

[0081] 16) Place the plate in a sterilizer and sterilize with circulating steam for 28 minutes;

[0082] 17) Label and pack.

[0083] Preferably, 5*10 cm sterile gauze is used in step 14).

[0084] Example 3

[0085] A topical medicinal oil for treating burns is prepared from the following raw materials in parts by weight: 8 parts of angelica dahurica, 18 parts of Scrophularia ningpoensis, 12 parts of Radix Rehmanniae, 12 parts of Angelica sinensis, 8 parts of Phellodendron chinense, 18 parts of Cortex Moutan, 8 parts of Carthamus tinctorius, 12 parts of Borneolum, 4 parts of Coptis chinensis, 12 parts of Polygonum cuspidatum, and 8 parts of Panax notoginseng.

[0086] A method for preparing an external medicinal oil for treating burns comprises the following steps:

[0087] 1) Equipment and auxiliary materials preparation: clean workshop ISO2 level; drying equipment, thermal disinfection; immersion equipment, thermal disinfection; filtering device, ultraviolet disinfection; heating equipment, thermal disinfection; disinfection equipment steam disinfection; device equipment, ultraviolet disinfection; isolation equipment, disinfection products; conveying equipment, ultraviolet disinfection; weighing equipment, compulsory inspection label; ion water cleaning / drying disinfection of sub-packaging glass bottles; prepare aluminum glass bottle caps, medical sterile gauze, standard edible oil, VE oil;

[0088] 2) Select raw materials and remove those with mildew, dampness, insects, impurities, or ash: Angelica dahurica, Scrophularia ningpoensis, Radix Rehmanniae, Angelica sinensis, Phellodendron chinense, Cortex Moutan, Carthamus tinctorius, Borneolum, Coptis chinensis, Polygonum cuspidatum, and Panax notoginseng;

[0089] 3) Dry the raw material at 62°C for 2 hours;

[0090] 4) Crush the dried raw materials to a size of 1 mm in diameter;

[0091] 5) Put the crushed raw materials into clean water and heat them to 88℃ for 2h;

[0092] 6) Soak at 28℃ for 48h;

[0093] 7) Stir once every 12 hours;

[0094] 8) Heat to 90℃ and soak for 2h;

[0095] 9) Soak at room temperature 25℃ for 48h;

[0096] 10) Stir once every 12 hours;

[0097] 11) Let stand for 4 hours;

[0098] 12) Filter with filter paper at 120℃;

[0099] 13) Add VE oil and stir evenly;

[0100] 14) Each bottle is rotated and filled with 50g sterile gauze;

[0101] 15) Pour 25 ml of standard edible oil and seal immediately;

[0102] 16) Place the plate in a sterilizer and sterilize with circulating steam for 32 minutes;

[0103] 17) Label and pack.

[0104] Preferably, 5*10 cm sterile gauze is used in step 14).

[0105] 1. Brief description of the efficacy of each ingredient

[0106] Angelica dahurica: warm in nature, pungent in taste, enters the lung, stomach, and large intestine meridians. It has the effects of dispelling wind and relieving pain, reducing swelling and draining pus. In the treatment of burns, its swelling-reducing effect can help relieve the local swelling caused by burns, create favorable conditions for subsequent repair, and guide the medicinal power of various drugs to the diseased area, promoting wound healing.

[0107] Scrophularia: slightly cold in nature, sweet, bitter and salty in taste, enters the lung, stomach and kidney meridians. It has the functions of clearing heat and cooling blood, nourishing yin and reducing fire, detoxifying and dispersing nodules. Burns are prone to heat toxins, and Scrophularia can clear heat, cool blood and detoxify, remove heat toxins caused by burns, inhibit inflammatory reactions, prevent heat toxins from further invading the body, and at the same time nourish yin and reduce fire, regulate the body's yin and yang balance, and facilitate the body's recovery.

[0108] Shengdi: cold in nature, sweet in taste, enters the heart, liver, and kidney meridians. It can clear away heat and cool blood, nourish yin and produce body fluid. It has a good regulating effect on the blood heat and yin and body fluid loss caused by burns. On the one hand, it can clear away heat and cool blood to calm blood heat and reduce wound bleeding and exudation; on the other hand, it can nourish yin and produce body fluid, replenish the body fluid lost due to burns, maintain the body's normal physiological functions, and promote wound healing.

[0109] Angelica sinensis: warm in nature, sweet and pungent in taste, it enters the liver, heart and spleen meridians. It is an important blood-tonifying medicine, and has the effects of promoting blood circulation and relieving pain, as well as moistening the intestines and relieving constipation. In the treatment of burns, the blood-activating and blood-stasis-removing effects of Angelica sinensis are crucial, which can improve the local blood circulation of the wound surface, enable nutrients and drug components to be more efficiently transported to the wound surface tissue, accelerate cell regeneration and repair, and at the same time replenish blood and enhance the body's ability to resist damage.

[0110] Phellodendron chinense: cold in nature, bitter in taste, enters kidney and bladder meridians. It has the functions of clearing away heat and dampness, purging fire and detoxifying, and removing bone steaming. Burn wounds are prone to the breeding of dampness and heat. Phellodendron chinense can strongly clear dampness and heat, inhibit the breeding of bacteria and fungi, and prevent wound infection. Its ability to purge fire and detoxify can cooperate with Scrophularia ningpoensis, Coptis chinensis, etc. to clear heat and toxins, and alleviate systemic symptoms after burns.

[0111] Cortex Moutan: slightly cold in nature, bitter and pungent in taste, and enters the heart, liver, and kidney meridians. It has the functions of clearing heat and cooling blood, promoting blood circulation and removing blood stasis. It can not only assist Radix Rehmanniae and Radix Scrophulariae in clearing heat and cooling blood, but also work with Radix Angelicae Sinensis to promote blood circulation on the wound surface and accelerate the dissipation of blood stasis. Cortex Moutan also contains ingredients such as Paeonia lactiflora, which have certain anti-inflammatory and antibacterial effects, and enhance the drug's anti-infection ability.

[0112] Safflower: warm in nature, pungent in taste, and enters the heart and liver meridians. It can promote blood circulation, relieve menstruation, and relieve pain. In the treatment of burns, safflower focuses on promoting blood circulation and removing blood stasis, improving wound microcirculation, providing adequate nutrient supply to injured tissues, accelerating wound healing, and relieving pain. It is used in combination with angelica and moutan bark to enhance the blood circulation effect.

[0113] Borneol: slightly cold in nature, pungent and bitter in taste, enters the heart, spleen and lung meridians. It has the effects of refreshing the mind, clearing away heat and relieving pain. When applied externally, borneol can quickly penetrate the skin, bring a cool feeling to the wound surface, and effectively relieve the pain of burns. Its heat-clearing function can assist in clearing away heat toxins, and borneol can also promote the transdermal absorption of other drugs, enhancing the overall efficacy of the drugs.

[0114] Coptis chinensis: cold in nature, bitter in taste, enters the heart, spleen, stomach, liver, gallbladder, and large intestine meridians. It has the effects of clearing away heat and dampness, purging fire and detoxifying. Coptis chinensis is a classic herbal medicine for clearing heat and detoxifying. It has a strong inhibitory effect on the heat and toxicity caused by burns. It has a broad-spectrum antibacterial effect and reduces the risk of wound infection. It works together with Phellodendron chinense and Scrophularia ningpoensis to strengthen the power of clearing heat and detoxifying, and protect the wound from heat and toxicity.

[0115] Polygonum cuspidatum: slightly cold in nature, slightly bitter in taste, and enters the liver, gallbladder, and lung meridians. It can clear away heat and detoxify, and can also promote dampness and reduce jaundice, relieve blood stasis and relieve pain, and relieve cough and phlegm. In the field of burn treatment, Polygonum cuspidatum has significant effects in clearing away heat and detoxifying, dispersing blood stasis and relieving pain. It can remove heat and toxins from the wound, reduce inflammatory reactions, promote the dissipation of blood stasis, and relieve pain. Its effect of promoting dampness and reducing jaundice can also regulate the body's water metabolism and help the body recover.

[0116] Panax notoginseng: warm in nature, sweet and slightly bitter in taste, and enters the liver and stomach meridians. It has the functions of removing blood stasis and stopping bleeding, promoting blood circulation and relieving pain. For burn wounds, Panax notoginseng can not only remove blood stasis and promote the discharge of blood stasis, but also stop bleeding and prevent excessive bleeding from the wound. It has a two-way regulation and maintains the local physiological balance of the wound. It is compatible with angelica, safflower, etc. to improve the blood circulation and hemostasis system and accelerate wound healing.

[0117] 2. The necessity and superiority of complementary combinations of ingredients

[0118] Heat-clearing, blood-cooling and detoxification system: It is composed of Scrophularia, Radix Rehmanniae, Phellodendron, Coptis chinensis, Polygonum cuspidatum, etc. After burns, heat and toxic invasion is the key pathological link. These herbs clear heat, cool blood and detoxify from different angles. Scrophularia and Radix Rehmanniae focus on cooling blood and nourishing yin, regulating the body's state of yin deficiency and blood heat caused by heat and toxicity; Phellodendron chinense and Coptis chinensis focus on clearing heat and drying dampness, purging fire and detoxifying, directly attacking the problems of damp heat and heat and heat and toxicity breeding on the wound surface; Polygonum cuspidatum has both heat-clearing and blood-dispersing properties, so that heat and toxicity are cleared and blood stasis is dispersed. They cooperate with each other to clear heat and toxicity in all directions, create a good internal environment for wound repair, and prevent heat and toxicity from further damaging body tissues and causing complications such as infection.

[0119] Blood circulation and stasis removal system: mainly composed of angelica, safflower, moutan bark, and panax notoginseng. Local blood circulation disorders on burn wounds seriously affect the healing process, and this system of medicinal materials can effectively improve this situation. Angelica nourishes blood and promotes blood circulation, providing nutritional support for wound repair; safflower and moutan bark strengthen blood circulation and menstruation, promote the dissipation of blood stasis, accelerate drug penetration and nutrient delivery; panax notoginseng removes blood stasis and stops bleeding, while promoting the discharge of blood stasis, ensuring proper hemostasis of the wound. They work synergistically to ensure smooth blood circulation on the wound, sufficient oxygen and nutrition for cells, accelerate wound healing, and reduce pain and swelling.

[0120] Swelling and pain relief system: Angelica dahurica and borneol play a key role, supplemented by blood-activating and stasis-removing drugs. Angelica dahurica can reduce swelling and discharge pus, quickly reduce swelling caused by burns, and lay the foundation for subsequent repair; borneol can clear away heat and relieve pain, and promote permeation through the skin, quickly relieving pain while helping other drugs to work. Blood-activating and stasis-removing drugs can improve local blood circulation and reduce the pain caused by blood stasis accumulation. The combination of the three, a multi-pronged approach, effectively relieves patients' pain and improves patient compliance.

[0121] Antibacterial and anti-infection system: Chinese medicinal materials such as Phellodendron chinense, Coptis chinensis, and Polygonum cuspidatum have natural antibacterial properties. Burn wounds are very susceptible to bacterial and fungal infections. These medicinal materials, with their own antibacterial ingredients, such as berberine in Phellodendron chinense and berberine in Coptis chinensis, have a significant inhibitory effect on common pathogens. Under synergistic effects, they build a strong antibacterial defense line, reduce the risk of wound infection, ensure a safe wound healing environment, reduce the use of antibiotics, and avoid the emergence of drug-resistant bacteria.

[0122] Comparative Example:

[0123] Raw material formula: Multiple Chinese medicinal materials were selected in imitation of the present invention, but the precise compatibility was not carried out according to the theory of traditional Chinese medicine. The weight of each medicinal material was arbitrarily determined: 20 parts of Angelica dahurica, 5 parts of Scrophularia ningpoensis, 6 parts of Rehmannia glutinosa, 20 parts of Angelica sinensis, 3 parts of Phellodendron chinense, 4 parts of Moutan bark, 4 parts of Carthamus tinctorius, 4 parts of Borneolum, 10 parts of Coptis chinensis, 20 parts of Polygonum cuspidatum, and 7 parts of Panax notoginseng.

[0124] Preparation process: Produced in a relatively clean environment (but below ISO Class 2 standard). The drying temperature of the raw materials was too high (80°C), resulting in the loss of some effective ingredients. Conventional soaking and filtering methods were used without alternating soaking and fine filtering, and the added antioxidants were not effective.

[0125] Drug performance: When treating burns, pain relief is not obvious, the quality of burn wound healing is poor, the new skin is rough, and 60% of patients have slight scars. During the treatment of 25 patients, 5 cases of wound infection occurred, indicating that its antibacterial and bactericidal ability is insufficient. Toxicology tests showed that it had a certain impact on the liver and kidney functions of some patients, and blood biochemical indicators showed slight abnormalities.

[0126] Scope of application: Suitable for mild to moderate burns, basically ineffective for diseases such as abscesses and vasculitis.

[0127] Comparative analysis:

[0128] Compared with the comparative example, the present invention ensures the effectiveness and safety of the drug based on the precise compatibility of traditional Chinese medicine theory and the reasonable preparation process. Due to the unreasonable formula and poor preparation process of the comparative example, the drug has obvious defects in therapeutic effect, safety and application scope, such as poor healing quality, high risk of infection and influence on liver and kidney function, while the present invention performs well in these aspects, further proving the advantages of the present invention.

[0129] In summary, by comparison with the comparative examples, the advantages of the present invention in terms of raw material formula, preparation process, drug performance and application range are fully reflected. It is a safer, more effective and practical burn treatment drug with broad application prospects and value.

[0130] Based on the theory of traditional Chinese medicine, it is concluded that the treatment of burns requires dredging the meridians, cooling the blood and detoxifying, restoring the biochemical operation of the vital energy, stimulating metabolism, and enhancing the autoimmune function, so that the burn wound surface can be regenerated and repaired. Therefore, a topical dressing treatment oil was developed. This medicine treats burns without pain, does not require skin grafting, and the burn wound surface is smooth and has no obvious scars.

[0131] 1. Experimental animals and groups

[0132] Several healthy adult mice weighing between 20-25 g were selected and randomly divided into an experimental group and a control group. The number of mice in each group was sufficient to ensure the reliability and statistical significance of the experimental results, with 20 mice in each group.

[0133] (II) Modeling method

[0134] A standardized burn model establishment method was used to scald a specific area on the back of mice to simulate human burns. The scald area was controlled at 10%-15% of the mouse's body surface area to ensure the consistency and repeatability of the scald degree. A precise temperature-controlled scalding instrument was used to set the scalding temperature to 80-90°C and the scalding time to 5-8 seconds to create a second-degree burn model.

[0135] (III) Method of administration

[0136] After the experimental group mice were burned, the medicated oil of the present invention was evenly applied to the burn wound immediately. The application dosage was accurately calculated according to the weight of the mice and the burn area. Each mouse was applied with about 0.1-0.2 ml of the medicated oil each time, and applied 2-3 times a day to ensure that the drug fully covered the wound and lasted. The control group mice were applied with an equal amount of physiological saline or blank control agent, and the application method and frequency were the same as those of the experimental group to ensure the consistency of the experimental conditions and exclude the interference of other factors on the experimental results.

[0137] (IV) Observation indicators and detection methods

[0138] 1. Epidermal regeneration

[0139] At different time points after the burn (3 days, 7 days, and 14 days), the burn wounds of the mice were photographed and recorded, and the wound healing area was measured using image analysis software. By comparing the wound healing rates of the experimental group and the control group at each time point, the drug's effect on promoting epidermal regeneration was evaluated. The results showed that the wound healing rate of the experimental group mice reached 50%-60% 7 days after the burn, while that of the control group was only 20%-30%; by 14 days, the wounds of the experimental group were basically healed, with a healing rate of more than 90%, while the healing rate of the control group was between 60%-70%, indicating that the drug oil can significantly promote epidermal regeneration.

[0140] 2. Local anesthetic effect

[0141] The reaction time of mice to pain was measured by the hot plate method or tail flick method to observe the local anesthetic effect of the drug oil. At different time intervals of 2 minutes, 4 minutes, 6 minutes, and 8 minutes after administration, the mice were placed on a hot plate (the temperature was set at 50-55°C) or the tails of the mice were gently lifted, and the latency of the mice to first lick their hind feet or flick their tails was recorded. The experimental data showed that the mice in the experimental group began to show obvious anesthetic effects 6-7 minutes after applying the drug oil, and the latency of pain response was significantly prolonged, which was statistically different from the control group (P<0.05), indicating that the drug oil has a definite local anesthetic effect and can effectively relieve pain after burns.

[0142] 3. Analgesic effect

[0143] The analgesic test was conducted using the acetic acid writhing method in mice. One hour after the burn, the experimental group and the control group were intraperitoneally injected with 0.6%-0.8% acetic acid solution, with a dose of 0.1ml / 10g body weight, and the number of writhing times of the mice within 15-30 minutes was observed and recorded. The number of writhing times of the mice in the experimental group was significantly less than that of the control group, with an average reduction of 40%-50%, which further confirmed the analgesic effect of the drug oil, which can reduce the pain stimulation caused by burns and improve the comfort of mice.

[0144] 4. Vascular permeability inhibition

[0145] Vascular permeability was assessed by injecting Evans blue dye through the tail vein and then observing the degree of blue dyeing of the skin at the burn site. 24 hours after the burn, an appropriate amount of Evans blue dye solution (concentration of 1%-2%, dosage of 0.2-0.3ml / mouse) was injected into the tail vein of mice in the experimental group and the control group. The mice were killed 30 minutes later, the skin at the burn site was removed, and the dye was extracted by soaking in formamide solution. The absorbance value was measured at a wavelength of 620nm using a spectrophotometer to reflect the change in vascular permeability. The amount of Evans blue dye exuded from the burn site of mice in the experimental group was significantly lower than that in the control group, and the absorbance value decreased by 30%-40%, indicating that the medicated oil can effectively inhibit the vascular permeability of the scalded site and reduce tissue edema and inflammatory response.

[0146] 5. Antibacterial and bactericidal effects

[0147] The wound secretions of burned mice were collected for bacterial culture and drug sensitivity test. The secretions were inoculated on a culture medium containing different bacteria (including eleven common bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa). After culturing for 24-48 hours, the growth of colonies was observed. The number of bacterial colonies in the wound secretions of mice in the experimental group was significantly less than that in the control group. The diameters of the inhibition zones for Staphylococcus aureus and Pseudomonas aeruginosa reached 15-20mm and 12-18mm, respectively, indicating that the drug oil has significant antibacterial and bactericidal effects on a variety of bacteria, can effectively prevent and control the infection of burn wounds, and create a good environment for wound healing.

[0148] 6. Toxicity Test

[0149] During the whole experiment, the general conditions of the experimental and control groups were closely observed, including weight changes, diet, mental state, and behavioral activities. The mice were weighed regularly and their weight gain was recorded weekly. There was no significant difference between the weight gain of the experimental group and the control group, with an average weekly weight gain of 2-3 g, indicating that the drug had no adverse effects on the growth and development of the mice. At the end of the experiment, blood was collected from the mice for blood routine and biochemical index tests, including white blood cell count, red blood cell count, hemoglobin content, alanine aminotransferase, aspartate aminotransferase, creatinine, urea nitrogen and other indicators. All indicators of the experimental group were within the normal range, and there was no statistical difference compared with the control group (P>0.05). At the same time, the heart, lung, liver, kidney and other important organs of the mice were dissected, and the morphology and color of the organs were observed with the naked eye. No obvious abnormal changes were observed. Tissue sections were made for pathological examination. The tissue structure of each organ was intact under the light microscope, and there was no pathological changes such as inflammatory cell infiltration, cell degeneration and necrosis, which further confirmed that the drug oil was non-toxic, non-irritating and non-sensitizing, and had good safety.

[0150] 2. Treatment Cases

[0151] Case 1

[0152] Patient information: Patient Zhang, male, 35 years old, was accidentally scalded by high-temperature liquid at work. The scald area reached 15%, mainly concentrated in both upper limbs and chest, and the depth of the burns ranged from superficial second degree to deep second degree.

[0153] Treatment process: The patient was immediately sent to the hospital after the injury, and after debridement, the medicated oil of the present invention was used for treatment. The medicated oil was applied three times a day, and the wound surface was gently massaged during application to make the medicated oil evenly covered. At the same time, appropriate anti-infection and nutritional support treatments were given.

[0154] Treatment effect: On the third day after treatment, the patient's burn wound pain was significantly relieved and the redness and swelling subsided. On the seventh day, the wound began to show obvious signs of healing, and some wounds began to scab. After 2 weeks of treatment, the wound was basically healed, the new skin was soft and smooth, and no obvious scars were formed. The patient's limb function recovered well and was very satisfied with the treatment effect.

[0155] Case 2

[0156] Patient information: Patient Li, female, 28 years old, was accidentally burned on the face and neck by flames at home. The burn area was about 10%, and the degree of burn was deep second degree.

[0157] Treatment process: After emergency treatment, the patient was treated locally with this medicated oil 4 times a day, combined with routine measures such as fluid replacement and infection prevention. During the treatment, the wound healing and the patient's systemic response were closely observed.

[0158] Treatment effect: After one week of treatment, the inflammatory reaction of the burn wounds on the patient's face and neck was alleviated, the pain was relieved, and the exudate was reduced. After two weeks, the wound surface began to epithelialize and the new skin grew well. After one month, the wound surface was completely healed, and the color of the new skin was close to that of normal skin, with no obvious scars and pigmentation. The patient's appearance recovered well and his mental state was greatly improved.

[0159] Case 3

[0160] Patient information: The patient, Mr. Wang, a child, 8 years old, was scalded on both lower limbs by boiling water while playing. The scald area was 20%, most of which were superficial second-degree burns and some were deep second-degree burns.

[0161] Treatment process: After being rushed to the hospital, the medicated oil of the present invention is used for bandaging treatment after debridement. The dressing is changed twice a day. The treatment plan is adjusted in time according to the recovery of the child, and the psychological state and limb activities of the child are observed.

[0162] Treatment effect: After 10 days of treatment, the superficial second-degree burn wounds were basically healed, the deep second-degree burn wounds were also significantly reduced, and the healing process was accelerated. After 3 weeks, the burn wounds on both lower limbs of the child were completely healed, the new skin was smooth, there was no scar contracture, the limbs moved freely, and there was no adverse effect on the growth and development of the child. The parents highly recognized the treatment effect.

[0163] Case 4

[0164] Patient information: Mr. Zhao, male, 45 years old, suffered multiple burns all over his body due to a kitchen fire. The burn area reached 30%, involving the back, abdomen and limbs. The depth of the burns was a mixture of superficial second degree and deep second degree.

[0165] Treatment process: After the patient was admitted to the hospital, a comprehensive debridement treatment was first performed to remove necrotic tissue and contaminants from the burn wound. Subsequently, the medicated oil of the present invention was evenly applied to the wound surface, applied 3 times a day, and bandaged with sterile gauze. At the same time, intravenous rehydration was given to correct electrolyte disorders, infection prevention treatment and nutritional support treatment, and the patient's vital signs and wound healing were closely monitored.

[0166] Treatment effect: On the 5th day after treatment, the redness, swelling and pain of the patient's burn wounds were significantly reduced, and the exudate decreased. On the 10th day, some superficial second-degree burn wounds began to heal, and granulation tissue gradually grew on deep second-degree wounds. After 4 weeks of continuous treatment, most wounds healed well, the new skin was soft and elastic, and only a few parts had slight pigmentation. The limb function returned to normal, and the patient recovered smoothly and was discharged from the hospital.

[0167] Case 5

[0168] Patient information: Sun, female, 50 years old, was scalded on the right upper limb and chest by high-temperature steam while operating a machine in a factory. The burn area was approximately 18%, and the burn depth was deep second degree.

[0169] Treatment process: After the injury, the patient was rushed to the hospital, and after evaluation, routine treatment such as fluid replacement and analgesia was given, and then the medicated oil was used for treatment. The medicated oil was applied on time 4 times a day to ensure that the wound was fully covered, and physical therapy was used to promote local blood circulation. Bacterial culture and drug sensitivity tests were performed on the wound regularly, and the treatment plan was adjusted according to the results.

[0170] Treatment effect: After 2 weeks of treatment, wound inflammation was effectively controlled, pain was significantly relieved, and epithelialization began to appear. After 3 weeks, most of the wounds healed, the new skin was smooth, there was no obvious scar hyperplasia, upper limb activities were basically unrestricted, and the patient was able to carry out simple daily activities and was satisfied with the treatment effect.

[0171] Case 6

[0172] Patient information: Qian, male, 60 years old, accidentally knocked over a hot water bottle, resulting in scalds on both lower limbs, covering an area of ​​25%, of which 70% were superficial second-degree burns and 30% were deep second-degree burns.

[0173] Treatment process: After admission, the wound is cleaned quickly, and then the medicated oil is applied to the wound surface. Exposure therapy is used to keep the ward environment clean to avoid wound infection. The medicated oil is applied three times a day, and the changes in the wound healing process are closely observed, and the wound secretions are handled in time. At the same time, health education is provided to the patient, and he is guided to perform appropriate lower limb functional exercises.

[0174] Treatment effect: After 15 days of treatment, the superficial second-degree burn wounds were basically healed, the deep second-degree burn wounds were significantly reduced, and the pain was relieved. After 4 weeks, the burn wounds on both lower limbs were completely healed, the new skin had normal color, no scar contracture, the patient was able to walk normally, and the quality of life was significantly improved.

[0175] Case 7

[0176] Patient information: Zhou, female, 30 years old, was scalded on the face during treatment at a beauty salon due to an instrument failure. The burn area was 8% and the depth of the burn was second degree superficial.

[0177] Treatment process: The patient was immediately sent to the hospital. After simple treatment, the patient began to apply the medicated oil to the facial wound 5 times a day. At the same time, psychological counseling was given to relieve the patient's anxiety caused by facial burns. During the treatment, strict attention was paid to facial cleanliness to avoid contact of cosmetics and other irritants with the wound.

[0178] Treatment effect: After 1 week, the redness and swelling of the facial burn wound subsided, and the pain was significantly relieved. After 2 weeks, the wound was completely healed, and the new skin was smooth and delicate without pigmentation. The patient's facial appearance recovered well, and it did not cause adverse effects on his social life. The patient was very satisfied with the treatment effect.

[0179] Case 8

[0180] Patient information: Mr. Wu, male, 40 years old, suffered multiple burns all over his body due to a car fire caused by a car accident. The burn area is 35%, including the head, face, neck, limbs and torso. The depth of the burns varies, including superficial second degree, deep second degree and third degree burns.

[0181] Treatment process: After admission, a multidisciplinary team was quickly organized for rescue. After the vital signs were stabilized, the burn wounds were debrided in stages and batches, and the medicated oil was used for treatment. For superficial second-degree and some deep second-degree wounds, the medicated oil was applied by bandaging; for third-degree wounds, after early eschar excision and skin grafting, the medicated oil was used around the donor area and the skin grafting area to promote healing. At the same time, nutritional support, anti-infection treatment, and the prevention and treatment of complications were strengthened, and rehabilitation training was actively carried out.

[0182] Treatment effect: After 2 months of careful treatment and care, the patient's superficial second-degree and deep second-degree wounds were basically healed, the skin grafting area survived well, the wound healing quality was high, the new skin was soft and elastic, and the scar hyperplasia was not obvious. The patient gradually recovered his self-care ability and partial labor ability, his mental state gradually stabilized, and he was full of confidence in the subsequent recovery.

[0183] Case 9

[0184] Patient information: Zheng, male, 25 years old, was burned on the buttocks and back of the thighs by a campfire while doing outdoor sports. The burn area was 12%, which was a shallow second-degree burn.

[0185] Treatment process: After the injury, the patient went to the hospital after simple self-treatment. The doctor cleaned the wound and started to use this medicated oil for treatment. Apply the medicated oil three times a day, use exposure therapy, and instruct the patient to keep the wound clean and dry, and avoid long-term pressure on the wound. At the same time, give appropriate oral medications to relieve pain and prevent infection.

[0186] Treatment effect: After 10 days of treatment, the wound healed well, there was no sign of infection, the new skin was intact, the patient could move freely, there was no obvious impact on his daily activities, and he successfully resumed normal life and work.

[0187] Treatment process: After admission, emergency surgical debridement is performed to remove necrotic tissue. After surgery, the medicated oil is applied to the wound surface 4 times a day. Anti-infection, nutritional support and hyperbaric oxygen therapy are also performed to promote wound healing and tissue repair. Bacterial culture and drug sensitivity tests are performed on the wound surface regularly, and the use of antibiotics is adjusted according to the results.

[0188] Treatment effect: After 6 weeks of comprehensive treatment, the burn wound gradually healed, the new skin grew well, the muscle function was partially restored, and the mobility of the right arm improved. The patient was able to carry out some simple daily activities and was quite satisfied with the treatment effect. He continued to receive rehabilitation treatment to further restore limb function.

[0189] The present invention is synthesized by adding vegetable oil to more than a dozen natural Chinese medicinal materials, and is an oily agent with a fragrant smell and a slightly sweet and slightly bitter taste. Animal tests and experimental burn model tests at the pharmacological experimental base designated by the state have confirmed that the drug can promote epidermal regeneration, and the new skin is soft, smooth and scar-free after healing. The local anesthesia test shows an anesthetic effect after 6-7 minutes, and the mouse analgesia test shows that it has an analgesic effect. The vascular permeability test can inhibit the vascular permeability of the scalded part, and has an in vitro antibacterial and bactericidal effect. It has an antibacterial and bactericidal effect on eleven bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa. The local toxicity test shows that it is non-irritating and non-sensitizing. The toxicity test has no toxic reaction. The weight gain, normal diet, health and liveliness of the experimental mice, and the blood routine test, urine routine test, liver and kidney function are not significantly affected. No abnormal pathological changes were observed in the naked eye observation and tissue section army of important organ tissues such as skin, heart, lung, liver, and kidney. It can be seen that the medicated oil is non-toxic, non-irritating and non-sensitizing. It is a safe and effective external treatment drug, which can be used for emergency treatment of burns. It has unique advancement and wide practicality.

[0190] The quality inspection requirements for the present invention are as follows:

[0191] 1. The oil will not become sour or deteriorate after being placed at 35℃ and normal pressure for 60 days;

[0192] 2. No sediment is observed in the oil body by naked eye;

[0193] 3. The exposed skin of the mice was bandaged and no redness, swelling, heat or functional impairment was observed after 24 hours.

[0194] 4.5 fields of view without reproductive colonies;

[0195] 5.PH6-8;

[0196] 6. Filling quantity detection ±10%.

[0197] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A topical medicinal oil for treating burns, characterized in that: The invention is made from the following raw materials in parts by weight: 8-12 parts of angelica dahurica, 12-18 parts of Scrophularia ningpoensis, 12-18 parts of Rehmannia glutinosa, 8-12 parts of Angelica sinensis, 8-12 parts of Phellodendron chinense, 12-18 parts of Moutan bark, 8-12 parts of Carthamus tinctorius, 8-12 parts of Borneolum, 4-6 parts of Coptis chinensis, 8-12 parts of Polygonum cuspidatum and 8-12 parts of Panax notoginseng.

2. The external medicinal oil for treating burns according to claim 1, characterized in that: The invention is made from the following raw materials in parts by weight: 10 parts of angelica dahurica, 15 parts of scrophularia ningpoensis, 15 parts of raw rehmannia root, 10 parts of angelica sinensis, 10 parts of phellodendron amurense, 15 parts of moutan bark, 10 parts of safflower, 10 parts of borneol, 5 parts of coptis root, 10 parts of polygonum cuspidatum and 10 parts of notoginseng.

3. The external medicinal oil for treating burns according to claim 1, characterized in that: The invention is made from the following raw materials in parts by weight: 12 parts of angelica dahurica, 12 parts of scrophularia ningpoensis, 18 parts of raw rehmannia, 8 parts of angelica sinensis, 12 parts of phellodendron chinense, 12 parts of moutan bark, 12 parts of safflower, 8 parts of borneol, 6 parts of coptis chinensis, 8 parts of polygonum cuspidatum and 12 parts of notoginseng.

4. The external medicinal oil for treating burns according to claim 1, characterized in that: The invention is made from the following raw materials in parts by weight: 8 parts of angelica dahurica, 18 parts of Scrophularia ningpoensis, 12 parts of Rehmannia glutinosa, 12 parts of Angelica sinensis, 8 parts of Phellodendron amurense, 18 parts of Moutan bark, 8 parts of Carthamus tinctorius, 12 parts of Borneolum, 4 parts of Coptis chinensis, 12 parts of Polygonum cuspidatum and 8 parts of Panax notoginseng.

5. A method for preparing the external medicinal oil for treating burns as described in any one of claims 1 to 4, characterized in that: The following steps are involved: 1) Equipment and auxiliary materials preparation: clean workshop ISO2 level; drying equipment, thermal disinfection; Immersion equipment, thermal disinfection; Filtration equipment, UV disinfection; Heating equipment, thermal disinfection; Sterilization equipment steam sterilization; equipment and apparatus, ultraviolet sterilization; isolation equipment, sterilization products; Conveying equipment, UV disinfection; weighing equipment, compulsory inspection label; ion water cleaning / drying disinfection of sub-packaging glass bottles; prepare aluminum glass bottle caps, medical sterile gauze, standard edible oil, VE oil; 2) Select raw materials and remove those with mildew, dampness, insects, impurities, or ash: Angelica dahurica, Scrophularia ningpoensis, Radix Rehmanniae, Angelica sinensis, Phellodendron chinense, Cortex Moutan, Carthamus tinctorius, Borneolum, Coptis chinensis, Polygonum cuspidatum, and Panax notoginseng; 3) Dry the raw material at 58-62°C for 2 hours; 4) Crush the dried raw materials to a size of 0.5-1.5 mm in diameter; 5) Put the crushed raw materials into clean water and heat them to 88-92℃ for 2h; 6) Soak at 22-28℃ for 48h; 7) Stir once every 12 hours; 8) Heat to 90℃ and soak for 2h; 9) Soak at room temperature 25℃ for 48h; 10) Stir once every 12 hours; 11) Let stand for 4-6 hours; 12) Filter with filter paper at 120℃-150℃; 13) Add VE oil and stir evenly; 14) Each bottle is rotated and filled with 40-60g sterilized gauze; 15) Inject 25-35ml of standard edible oil and seal immediately; 16) Place the plate in a sterilizer and sterilize with circulating steam for 28-32 minutes; 17) Label and pack.

6. The preparation method according to claim 5, characterized in that: In the step 3), the raw material is dried at 60° C. for 2 hours.

7. The preparation method according to claim 5, characterized in that: The crushing standard in step 4) is 1 mm.

8. The preparation method according to claim 5, characterized in that: In the step 11), the mixture is allowed to stand for 5 hours.

9. The preparation method according to claim 5, characterized in that: In the step 14), 5*10 cm sterile gauze is used.

10. The preparation method according to claim 5, characterized in that: In step 15), 30 ml of standard edible oil is injected.

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