Targeted drug delivery system for nuclide treatment

Abstract

The invention discloses a targeted drug delivery system for nuclide therapy, which comprises a fixing device, an injection device and a rotating device, one end of the fixing device is provided with the rotating device, the top end of the fixing device is rotatably connected with the injection device, and the injection device can be driven by the rotating device to rotate and move. The injection speed and depth can be accurately adjusted through hand rocker control, it is ensured that medicine accurately reaches the tumor position, the accurate control improves the treatment effect, the risk of damage to surrounding healthy tissue is effectively reduced, in addition, an observation window is additionally arranged in the system design, medical staff can conveniently monitor the injection condition in real time, and the system is convenient to use. On the whole, due to the innovative design of the system, the safety and effectiveness of nuclide treatment are improved, and better treatment experience is provided for patients.

Description

Technical Field

[0001] The present invention relates to the technical field of drug delivery systems, in particular to a targeted drug delivery system for nuclide therapy. Background Art

[0002] In the field of radionuclide therapy, accurately delivering radionuclide solution to the tumor site is the key to improving treatment effects and reducing side effects. Traditional drug delivery methods have many shortcomings in targeted drug delivery. During the injection process, it is difficult to ensure that the injection needle reaches the tumor site accurately. Due to the lack of precise positioning and stable needle insertion control, the injection needle may deviate from the target position, resulting in the radionuclide drug being unable to effectively act on tumor cells. In some manual injection operations, medical staff rely solely on experience and visual judgment to insert the needle, which is easily affected by factors such as slight hand tremors, patient body movements, or errors in tumor location judgment, thereby reducing the effectiveness of the treatment. During the injection process, the state of the skin will also affect the drug delivery effect. If the skin cannot be properly fixed and flattened, it will not only increase the patient's discomfort, but may also cause the injection needle to enter the skin at an inaccurate angle or cause a deviation in the injection site.

[0003] In summary, in order to improve the effect of radionuclide therapy and reduce unnecessary risks, there is an urgent need for a targeted drug delivery system that can accurately control the injection process, stably push drugs, and assist in skin fixation and flattening. Summary of the invention

[0004] The object of the present invention is to provide a targeted drug delivery system for nuclide therapy to solve the problems raised in the above background technology.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a targeted drug delivery system for radionuclide therapy, comprising a fixing device, an injection device and a rotating device, wherein a rotating device is provided at one end of the fixing device, and the top end of the fixing device is rotatably connected to the injection device, and the injection device can be driven to rotate and move by the rotating device.

[0006] Preferably, the fixing device includes a cylindrical block, an outer shell, a first hollow cylinder, a cylinder, a rectangular plate and a first groove, the top end of the outer shell is fixedly provided with a cylindrical block, the bottom end of the outer shell is fixedly provided with a rectangular plate, the outer wall of the rectangular plate is provided with a first groove, a first hollow cylinder is fixedly provided on one side of the outer wall of the outer shell, and the inner cavity of the first hollow cylinder is provided with a thread.

[0007] Preferably, the injection device includes a round block, a round rod, a leather plug, a threaded barrel, a hollow cylinder, an injection needle and a first gear. The threaded barrel is located in the inner cavity of the first hollow cylinder and cooperates with the thread of the inner wall of the first hollow cylinder. A round block is fixedly provided at one end of the round rod, and a leather plug is fixedly provided at the other end of the round rod. The leather plug can slide in the inner cavity of the threaded barrel, and the outer wall of the leather plug is in contact with the inner cavity of the threaded barrel. A first gear is fixedly provided on one side of the outer wall of the threaded barrel, one end of the threaded barrel is fixedly provided with one end of a hollow cylinder, and an injection needle is fixedly provided at the other end of the hollow cylinder.

[0008] Preferably, the rotating device includes a second hollow cylinder, a first bevel gear, a second bevel gear, a hand crank, a first rotating shaft, a second rotating shaft, a cylinder, a cavity, a third rotating shaft, a second gear, a second groove, a third groove and a fixing rod, the outer wall of the second hollow cylinder is fixedly provided with one end of the fixing rod, the other end of the fixing rod is fixedly provided at one end of the top surface of the rectangular plate, and the outer wall of the third groove is contacted and fixed with the shell, the bottom of the second hollow cylinder is provided with a third groove, the third groove is sleeved and fixedly provided with the second rotating shaft, the second rotating shaft is sleeved and provided on the outer wall of the cylinder, and the cylinder can rotate through the second rotating shaft, one end of the cylinder is fixedly provided with the first bevel gear, the outer wall of the first bevel gear is provided with a second bevel gear whose surface is in contact with the first bevel gear, and the second bevel gear can be engaged with the first bevel gear The gears are meshed with each other, and a second gear is fixedly provided on the outer wall of the cylinder, and the second gear is meshed with the first gear, and one side of the bottom of the outer wall of the first gear is in contact with one side of the top of the outer wall of the second gear, and a cavity is provided on the bottom inner cavity of the cylinder, and a third rotating shaft is sleeved on the inner cavity of the cavity, and a cylindrical block is inserted into the inner cavity of the third rotating shaft, and the cylinder can rotate through the third rotating shaft.

[0009] Preferably, the hand crank rotates to make the second gear drive the first gear, and can make the threaded barrel rotate and move downward.

[0010] Compared with the prior art, the present invention has the following beneficial effects: 1. In the targeted drug delivery system for radionuclide therapy, the injection device and the rotating device form a precise transmission structure. During the injection process, the rotating device drives the threaded barrel of the injection device to rotate through a series of precise gears and shafts. The threaded barrel cooperates with the thread on the inner wall of the first hollow cylinder, so that the threaded barrel can only move downward slowly and steadily along the thread during rotation. This structural design can ensure that the injection needle enters the skin with a precise trajectory, avoiding needle insertion deviation caused by factors such as hand tremors or inaccurate positioning during manual operation, thereby increasing the possibility of accurately delivering the radionuclide drug to the tumor site.

[0011] 2. In the traditional manual injection process, it is difficult for medical staff to fully control the angle and depth of the needle. However, this system can control the insertion path of the injection needle within a very small error range through the precise transmission of the mechanical structure, greatly improving the accuracy of targeted drug delivery.

[0012] 3. The fixing device can fit the skin when in use, and its rectangular plate can help flatten the skin. During the injection process, the flat skin helps the injection needle to enter the skin vertically and reduce the deviation of the needle insertion angle. At the same time, a first groove is provided on the rectangular plate of the fixing device to facilitate medical staff to observe the fit between the skin and the device and whether there is blood exudation during the injection process. This skin fixation and flattening function not only improves the accuracy of the injection, but also increases the patient's comfort during the injection process and reduces the injection risk caused by skin movement or wrinkles.

[0013] 4. The hand crank design in the rotating device allows medical staff to easily operate the entire injection process. Medical staff only need to shake the hand crank to drive a series of gears and shafts to rotate, so as to achieve the insertion of the injection needle and the delivery of the drug. This operation method is simple and intuitive, does not require complicated operating skills, and reduces the difficulty of operation for medical staff. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a schematic diagram of the structure of the present invention; Figure 2 It is a schematic diagram of the structure of the fixing device of the present invention; Figure 3 It is a schematic diagram of the cross-sectional structure of the injection device of the present invention; Figure 4 It is a schematic diagram of the driving structure of the injection device of the present invention; Figure 5 It is a schematic diagram of the decomposition of the rotating structure of the present invention; Figure 6 It is a cross-sectional structural schematic diagram of the rotating structure of the present invention; Figure 7 It is a schematic diagram of the exploded structure of the bottom of the cylinder of the present invention; Figure 8 It is a schematic diagram of the fixing rod structure of the present invention.

[0015] In the figure: 1, fixing device, 2, injection device, 3, rotating device, 11, cylindrical block, 12, housing, 13, first hollow cylinder, 14, cylinder, 15, rectangular plate, 16, first groove, 21, round block, 22, round rod, 23, leather plug, 24, threaded barrel, 25, hollow cylinder, 26, injection needle, 27, first gear, 31, second hollow cylinder, 32, first bevel gear, 33, second bevel gear, 34, hand crank, 35, first rotating shaft, 36, second rotating shaft, 37, cylinder, 38, cavity, 39, third rotating shaft, 310, second gear, 311, second groove, 312, third groove, 313, fixing rod. DETAILED DESCRIPTION

[0016] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0017] See also Figure 1-8 The present invention provides a technical solution of a targeted drug delivery system for radionuclide therapy: it includes a fixing device 1, an injection device 2 and a rotating device 3. The rotating device 3 is provided at one end of the fixing device 1, and the top of the fixing device 1 is rotatably connected to the injection device 2. The rotating device 3 can drive the injection device 2 to rotate and move. When in use, the fixing device 1 is attached to one end of the skin, and can assist in flattening the skin to complete the injection. The transmission structure composed of the injection device 2 and the rotating device 3 is very precise, so that the injection process can be completed more accurately, ensuring that the radionuclide drug accurately reaches the tumor site, improving the treatment effect and reducing unnecessary risks.

[0018] As a preferred embodiment, further, the fixing device 1 includes a cylindrical block 11, an outer shell 12, a first hollow cylinder 13, a cylinder 14, a rectangular plate 15 and a first groove 16. The cylindrical block 11 is fixedly arranged on the top end of the outer shell 12, and the rectangular plate 15 is fixedly arranged on the bottom end of the outer shell 12. The outer wall of the rectangular plate 15 is provided with a first groove 16. The first groove 16 is provided to facilitate observation during use, such as observing the fit between the skin and the device, whether there is blood seepage, etc. A first hollow cylinder 13 is fixedly arranged on one side of the outer wall of the outer shell 12, and the inner cavity of the first hollow cylinder 13 is provided with a thread 14.

[0019] As a preferred embodiment, the injection device 2 further comprises a round block 21, a round rod 22, a leather plug 23, a threaded barrel 24, a hollow cylinder 25, an injection needle 26 and a first gear 27. The threaded barrel 24 is located in the inner cavity of the first hollow cylinder 13 and cooperates with the thread 14 on the inner wall of the first hollow cylinder 13. When the threaded barrel 24 rotates, the threaded barrel 24 can move downward through the thread 14 on the inner wall of the first hollow cylinder 13. The round block 21 is fixedly provided at one end of the round rod 22, and the leather plug 23 is fixedly provided at the other end of the round rod 22. The leather plug 23 can slide in the inner cavity of the threaded barrel 24, and the leather plug 23 can slide in the inner cavity of the threaded barrel 24. The outer wall of the plug 23 is in contact with the inner cavity of the threaded barrel 24. A first gear 27 is fixedly provided on one side of the outer wall of the threaded barrel 24, and the red tooth of the first gear 27 is designed to be relatively long. One end of the threaded barrel 24 is fixedly provided with one end of a hollow cylinder 25, and the other end of the hollow cylinder 25 is fixedly provided with an injection needle 26. When the threaded barrel 24 moves downward by rotating, it moves slowly downward through the inclined surface of the thread 14. This slow and stable movement method can enable the injection needle 26 to enter the skin more accurately, avoiding unnecessary harm to the patient due to excessive speed or inaccurate positioning.

[0020] As a preferred embodiment, further, the rotating device 3 includes a second hollow cylinder 31, a first bevel gear 32, a second bevel gear 33, a hand crank 34, a first rotating shaft 35, a second rotating shaft 36, a cylinder 37, a cavity 38, a third rotating shaft 39, a second gear 310, a second groove 311, a third groove 312 and a fixing rod 313, the outer wall of the second hollow cylinder 31 is fixedly provided with one end of the fixing rod 313, the other end of the fixing rod 313 is fixedly provided at one end of the top surface of the rectangular plate 15, and the outer wall of the third groove 313 is connected to the outer shell 1 2 contact fixation, a third groove 312 is provided at the bottom of the second hollow cylinder 31, a second rotating shaft 36 is sleeved and fixedly arranged on the third groove 312, the second rotating shaft 36 is sleeved and arranged on the outer wall of the cylinder 37, and the cylinder 37 can rotate through the second rotating shaft 36, a first bevel gear 32 is fixedly arranged on one end of the cylinder 37, a second bevel gear 33 is arranged on the outer wall of the first bevel gear 32, and the second bevel gear 33 can mesh with the first bevel gear 32, and this meshing mode of the bevel gears can effectively change the power The transmission direction, a second groove 311 is opened on one side of the outer wall of the second hollow cylinder 31, and the second groove 311 is sleeved with a first rotating shaft 35, and the first rotating shaft 35 is sleeved on the outer wall of one end of the hand crank 34, and the hand crank 34 can rotate through the first rotating shaft 35, and one end of the hand crank 34 is fixed to the inner cavity of the second bevel gear 33, and the hand crank 34 rotates the second bevel gear 33 through the first rotating shaft 35, and the second bevel gear 33 is meshed with the first bevel gear 32 to drive the cylinder 37 to rotate, and the outer wall of the cylinder 37 is fixedly provided with The second gear 310 is meshed with the first gear 27, and the bottom side of the outer wall of the first gear 27 is in contact with the top side of the outer wall of the second gear 310. This precise meshing relationship ensures the effective transmission of power. A cavity 38 is provided in the bottom inner cavity of the cylinder 37. A third rotating shaft 39 is sleeved in the inner cavity of the cavity 38. A cylindrical block 11 is inserted in the inner cavity of the third rotating shaft 39, and the cylinder 37 can rotate through the third rotating shaft 39. This structure further ensures the stability and accuracy of the cylinder 37 during rotation.

[0021] As a preferred solution, further, the hand crank 34 rotates to make the second gear 310 drive the first gear 27, and can make the threaded barrel 24 rotate and move downward. During operation, the medical staff shakes the hand crank 34, and the hand crank 34 drives the second bevel gear 33 to rotate. The engagement of the second bevel gear 33 with the first bevel gear 32 causes the cylinder 37 to start rotating, and the second gear 310 on the cylinder 37 rotates accordingly. Since the second gear 310 is engaged with the first gear 27, the first gear 27 starts to rotate, thereby driving the threaded barrel 24 to rotate. The threaded barrel 24 can only move downward along the thread under the restriction of the thread structure of the first hollow cylinder 13, thereby pushing the round block 21 to make the leather plug 23 push the radionuclide medicine, and finally making the injection needle 26 slowly and accurately penetrate the skin and inject the medicine into the tumor site. During the whole process, the close cooperation and precise transmission between the various components ensure the efficiency and accuracy of the targeted drug delivery system for radionuclide therapy.

[0022] The detailed connection means are well-known technologies in the art. The following mainly introduces the working principle and process. The specific operation is as follows: the drug solution is input into the inner cavity through one end of the threaded barrel 24, and the leather plug 23 is inserted into the inner cavity of the threaded barrel 24 to complete the injection solution filling. When the tumor needs to be injected, the first groove 16 is placed at the position where the injection is required, and the second bevel gear 33 drives the first bevel gear 32 by rotating the hand crank 34, and drives the cylinder 37 to rotate through the third rotating shaft 39. Since the second gear 310 is meshed with the first gear 27, the first gear 27 drives the threaded barrel 24 to move downward so that the injection needle 26 is inserted into the skin. Since the transmission structure composed of the second gear 310 and the first gear 27 can accurately move the injection needle 26, the injection needle 26 can be inserted into the skin at a fixed point to locate the tumor by controlling the rotation of the hand crank 34. When the injection needle 26 is inserted to the fixed point, the round block 21 is pressed to cause the round rod 22 to drive the leather plug 23 to move to discharge the drug solution from the injection needle 26 to the tumor position to complete the injection.

[0023] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A targeted drug delivery system for radionuclide therapy, characterized in that: The invention comprises a fixing device (1), an injection device (2) and a rotating device (3), wherein one end of the fixing device (1) is provided with the rotating device (3), the top end of the fixing device (1) is rotatably connected to the injection device (2), and the injection device (2) can be driven to rotate and move via the rotating device (3).

2. A targeted drug delivery system for nuclide therapy according to claim 1, characterized in that: The fixing device (1) comprises a cylindrical block (11), an outer shell (12), a first hollow cylinder (13), a cylinder (14), a rectangular plate (15) and a first groove (16); the cylindrical block (11) is fixedly arranged at the top end of the outer shell (12); the rectangular plate (15) is fixedly arranged at the bottom end of the outer shell (12); the first groove (16) is formed on the outer wall of the rectangular plate (15); and the first hollow cylinder (13) is fixedly arranged on one side of the outer wall of the outer shell (12).

3. A targeted drug delivery system for nuclide therapy according to claim 2, characterized in that: The inner cavity of the first hollow cylinder (13) is provided with a thread (14).

4. A targeted drug delivery system for nuclide therapy according to claim 3, characterized in that: The injection device (2) comprises a round block (21), a round rod (22), a leather plug (23), a threaded barrel (24), a hollow cylinder (25), an injection needle (26) and a first gear (27). The threaded barrel (24) is located in the inner cavity of the first hollow cylinder (13) and cooperates with the thread (14) on the inner wall of the first hollow cylinder (13). The round block (21) is fixedly arranged at one end of the round rod (22), the leather plug (23) is fixedly arranged at the other end of the round rod (22), the first gear (27) is fixedly arranged on one side of the outer wall of the threaded barrel (24), one end of the hollow cylinder (25) is fixedly arranged at one end of the threaded barrel (24), and the injection needle (26) is fixedly arranged at the other end of the hollow cylinder (25).

5. A targeted drug delivery system for nuclide therapy according to claim 4, characterized in that: The leather plug (23) is able to slide in the inner cavity of the threaded barrel (24), and the outer wall of the leather plug (23) is in contact with the inner cavity of the threaded barrel (24).

6. A targeted drug delivery system for nuclide therapy according to claim 5, characterized in that: The rotating device (3) comprises a second hollow cylinder (31), a first bevel gear (32), a second bevel gear (33), a hand crank (34), a first rotating shaft (35), a second rotating shaft (36), a cylinder (37), a cavity (38), a third rotating shaft (39), a second gear (310), a second groove (311), a third groove (312) and a fixing rod (313), wherein one end of the fixing rod (313) is fixedly arranged on the outer wall of the second hollow cylinder (31), the other end of the fixing rod (313) is fixedly arranged on one end of the top surface of the rectangular plate (15), and the third groove (312) is fixedly arranged on the outer wall of the second hollow cylinder (31). The outer wall of the groove (313) is in contact with and fixed to the housing (12); a third groove (312) is provided at the bottom of the second hollow cylinder (31); a second rotating shaft (36) is sleeved and fixedly arranged in the third groove (312); the second rotating shaft (36) is sleeved and arranged on the outer wall of the cylinder (37); the cylinder (37) can rotate through the second rotating shaft (36); a first bevel gear (32) is fixedly arranged at one end of the cylinder (37); a second bevel gear (33) is provided on the outer wall of the first bevel gear (32) in contact with the surface; and the second bevel gear (33) can rotate with the second bevel gear (33). A second hollow cylinder (31) is provided with a second groove (311) on one side of the outer wall of the second hollow cylinder (31), a first rotating shaft (35) is sleeved on the second groove (311), the first rotating shaft (35) is sleeved on the outer wall of one end of a hand crank (34), and the hand crank (34) can rotate through the first rotating shaft (35), one end of the hand crank (34) is fixed to the inner cavity of the second bevel gear (33), the hand crank (34) rotates the second bevel gear (33) through the first rotating shaft (35), and the second bevel gear (33) and the first bevel gear (33) are meshed with each other. (32) mesh with each other to drive the cylinder (37) to rotate, a second gear (310) is fixedly arranged on the outer wall of the cylinder (37), the second gear (310) is meshed with the first gear (27), and the bottom side of the outer wall of the first gear (27) is in contact with the top side of the outer wall of the second gear (310), a cavity (38) is opened in the bottom inner cavity of the cylinder (37), a third rotating shaft (39) is sleeved in the inner cavity of the cavity (38), a cylindrical block (11) is inserted in the inner cavity of the third rotating shaft (39), and the cylinder (37) can rotate through the third rotating shaft (39).

7. A targeted drug delivery system for nuclide therapy according to claim 6, characterized in that: The hand crank (34) rotates to cause the second gear (310) to drive the first gear (27), and can cause the threaded barrel (24) to rotate and move downward.

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