Traditional Chinese medicine composition for treating cancer pain, traditional Chinese medicine acupoint patch and preparation method thereof

Abstract

The present application discloses a Chinese medicine composition for treating cancer pain, a Chinese medicine acupoint patch and a preparation method thereof, wherein the Chinese medicine composition is composed of the following raw materials in parts by weight: 30-60 parts by weight of Gleditsia sinensis, 15-30 parts by weight of Curcuma zedoariae, 15-30 parts by weight of Tripterygium wilfordii, 5-10 parts by weight of dried ginger, 10-20 parts by weight of Angelica dahuricae, 3-6 parts by weight of Carthamus tinctorius, 5-10 parts by weight of Eupolyphaga sinensis, 5-10 parts by weight of Pheretima lumbricoides, and 3-6 parts by weight of Panax notoginseng. The Chinese medicine acupoint patch for treating cancer pain prepared by the present invention has the effects of promoting blood circulation and removing blood stasis, dispersing stagnation and eliminating symptoms, and dredge meridians to relieve pain, is easy to use, and has good patient compliance.

Description

Technical Field

[0001] The present application belongs to the technical field of traditional Chinese medicine, and in particular, relates to a traditional Chinese medicine composition for treating cancer pain, a traditional Chinese medicine acupuncture patch and a preparation method thereof. Background Art

[0002] Patients with advanced malignant tumors often suffer from cancer pain, which seriously affects their quality of life. It not only brings physical pain, but may also lead to a decline in psychological and social functions.

[0003] Existing cancer pain treatment methods are mainly divided into two categories: non-drug and drug treatment. Non-drug treatments include radiotherapy, chemotherapy, analgesics and bisphosphonates, but they have limitations. For example, radiotherapy is not effective for multiple bone metastases, and chemotherapy has significant side effects. In drug treatment, although opioid analgesics are effective, they are prone to drug dependence and side effects. The application of traditional Chinese medicine in cancer pain treatment is increasingly valued. It relieves pain by harmonizing qi and blood and unblocking meridians, but traditional Chinese medicine prescriptions are complex, with different functions and indications, and some drugs have adverse reactions and clinical application limitations.

[0004] Therefore, developing drugs with significant clinical efficacy and few side effects has become an important direction of effort for medical workers. Summary of the invention

[0005] The purpose of the present application is to provide a Chinese medicine composition for treating cancer pain, a Chinese medicine acupoint patch and a preparation method thereof, so as to solve the above-mentioned technical problems.

[0006] In order to achieve the above application purpose, the technical solution adopted in this application is as follows:

[0007] In a first aspect, the present invention provides a Chinese medicine composition for treating cancer pain, which is composed of the following raw materials in parts by weight:

[0008] 30-60 parts by weight of Gleditsia sinensis spines, 15-30 parts by weight of Curcuma zedoaria, 15-30 parts by weight of Tripterygium wilfordii, 5-10 parts by weight of dried ginger, 10-20 parts by weight of Angelica dahurica, 3-6 parts by weight of Carthamus tinctorius, 5-10 parts by weight of Eupolyphaga sinensis, 5-10 parts by weight of Pheretima lumbricoides, and 3-6 parts by weight of Panax notoginseng.

[0009] Optionally, the Chinese medicine composition is composed of the following raw materials in parts by weight:

[0010] 30 parts by weight of Gleditsia sinensis, 15 parts by weight of Curcuma zedoaria, 15 parts by weight of Tripterygium wilfordii, 5 parts by weight of dried ginger, 10 parts by weight of Angelica dahurica, 3 parts by weight of Carthamus tinctorius, 5 parts by weight of Eupolyphaga sinensis, 5 parts by weight of Pheretima lumbricoides, and 3 parts by weight of Panax notoginseng.

[0011] Optionally, the mass ratio of Gleditsia sinensis, Rhizoma Trigonellae and Rhizoma Curcumae is 2:1:1.

[0012] In a second aspect, an embodiment of the present application provides a traditional Chinese medicine acupuncture patch for treating cancer pain, which is composed of a Babu paste base and the traditional Chinese medicine composition provided in the first aspect above.

[0013] In a third aspect, the present application provides a method for preparing a Chinese medicine acupuncture patch for treating cancer pain, comprising:

[0014] (1) Prepare raw materials:

[0015] Weigh the following medicinal materials according to the following proportions: 30-60 parts by weight of Gleditsia sinensis, 15-30 parts by weight of Curcuma zedoaria, 15-30 parts by weight of Tripterygium wilfordii, 5-10 parts by weight of Dried Ginger, 10-20 parts by weight of Angelica dahurica, 3-6 parts by weight of Carthamus tinctorius, 5-10 parts by weight of Eupolyphaga sinensis, 5-10 parts by weight of Pheretima lumbricoides, and 3-6 parts by weight of Panax notoginseng;

[0016] Sodium polyacrylate, polyvinyl pyrrolidone, aluminum glycolate, disodium ethylenediaminetetraacetate, tartaric acid and glycerin are used as raw materials of the Babu ointment base;

[0017] (2) Preparation of thick paste:

[0018] Soak dried ginger, Gleditsia sinensis, Angelica dahurica, safflower, Eupolyphaga sinensis, Curcuma zedoaria, and Tripterygium wilfordii in water until thoroughly moistened, then boil and extract, collect the extract, and concentrate under reduced pressure to obtain a thick paste;

[0019] (3) Preparation of ultrafine powder:

[0020] Drying the earthworm and Panax notoginseng, ultrafine grinding, and sieving to obtain ultrafine powder of Panax notoginseng and earthworm;

[0021] (4) Preparation of acupoint stickers:

[0022] Disperse sodium polyacrylate, disodium ethylenediaminetetraacetic acid and aluminum glycolate in glycerol as phase A; take purified water, add polyvinyl pyrrolidone and tartaric acid in sequence, and add thick paste and ultrafine powder as phase B after they are fully dissolved; add phase B into phase A in small amounts several times, stir evenly to form an ointment, quickly apply it on the backing material, and leave it to dry and form at room temperature to obtain a traditional Chinese medicine acupuncture patch.

[0023] Optionally, (1) in preparing raw materials, weigh the medicinal materials according to the following proportions:

[0024] 30 parts by weight of Gleditsia sinensis, 15 parts by weight of Curcuma zedoaria, 15 parts by weight of Tripterygium wilfordii, 5 parts by weight of dried ginger, 10 parts by weight of Angelica dahurica, 3 parts by weight of Carthamus tinctorius, 5 parts by weight of Eupolyphaga sinensis, 5 parts by weight of Pheretima lumbricoides, and 3 parts by weight of Panax notoginseng

[0025] Optionally, the mass ratio of Gleditsia sinensis, Rhizoma Trigonellae and Rhizoma Curcumae is 2:1:1.

[0026] Compared with the prior art, the beneficial effects of the embodiments of the present application are:

[0027] 1. A Chinese medicine composition for treating cancer pain, a Chinese medicine acupuncture patch and a preparation method thereof provided in the embodiments of the present application, wherein the effective ingredients of the acupuncture patch include dried ginger, Gleditsia sinensis, Angelica dahurica, safflower, Eupolyphaga sinensis, Curcuma zedoaria, Tripterygium wilfordii, Pheretima lumbricoides, and Panax notoginseng. Among them, Gleditsia sinensis has the functions of reducing swelling, clearing pus, promoting blood circulation and dispersing nodules, and has the largest dosage. It is the main medicine, and its pungent, dispersing, warming and unblocking power can penetrate the lesion, promote the penetration of drug efficacy, and can also lead the drug directly to the diseased area, targeting the local stagnation of the tumor. Curcuma zedoaria and Tripterygium wilfordii can break blood and promote qi circulation, eliminate accumulation and relieve pain. The two synergistically enhance the power of the main medicine to break blood and eliminate symptoms, targeting the core pathogenesis of the tumor (blood stasis and qi stagnation), and directly inhibit the accumulation of symptoms. Safflower and Eupolyphaga sinensis can promote blood circulation, promote menstruation, remove blood stasis and eliminate symptoms, and are all ministerial medicines. Dry ginger and Angelica dahurica warm the meridians and dispel cold, and have a pungent and fragrant aroma. They help the drug penetrate the skin surface and prevent cold and blood stasis. Earthworms can dredge the meridians and relieve pain, improve the local circulation of qi and blood, and relieve pain. They are adjuvant drugs. Panax notoginseng has the functions of dispersing blood stasis and stopping bleeding, reducing swelling and relieving pain, and harmonizing various drugs to prevent excessive blood breaking and bleeding. It also has an analgesic effect and guides the coordination of drug power. It is a guiding drug. This prescription is mainly warming and unblocking: Dry ginger, Angelica dahurica, Gleditsia sinensis and other warm drugs are dominant, and are suitable for cold and blood stasis type tumors. Breaking and eliminating: Curcuma zedoaria, Tripterygium wilfordii, and Eupolyphaga sinensis specialize in treating lumps and masses, while safflower and Panax notoginseng take into account blood circulation and hemostasis, and attack without being fierce. Internal and external regulation: external transdermal absorption (Gleditsia sinensis and Angelica dahurica promote penetration), directly acting on the lesions, reducing the side effects of oral administration. In summary, this prescription achieves the dual goals of "tumor elimination" and "pain relief" through the synergistic effect of multiple targets, reflecting the treatment idea of ​​"using unblocking as the purpose" in traditional Chinese medicine.

[0028] 2. In the preparation method of the present invention, dried ginger, Gleditsia sinensis, Angelica dahurica, safflower, Eupolyphaga sinensis, Curcuma zedoaria, and Tripterygium wilfordii are soaked in water until they are thoroughly moistened, then boiled for extraction, the extract is collected, and concentrated under reduced pressure to obtain a thick paste, thereby achieving full extraction of the effective ingredients of the drug by the reduced pressure concentration technology.

[0029] 3. After Panax notoginseng and earthworms are dried to a certain degree, it is conducive to ultrafine grinding to obtain ultrafine powder of the drug. The ultrafine powder has a large viscosity and the powder particles are more tightly bonded to each other, which is more conducive to the preparation of ointments with stronger "adhesion" and "adhesion" and can fit closely to the surface of human skin. The ultrafine powder is also easier to be absorbed through the skin into the blood, acting on the painful area and exerting the effective effect of the drug.

[0030] 4. The Chinese medicine acupuncture patch for treating cancer pain prepared by the present invention can be applied to the painful part, has a slow-release and long-acting function, and the effective ingredients can act on the affected part for a long time. The acupuncture patch is easy to use and has good patient compliance.

[0031] 5. The Babu plaster matrix of the present invention mainly plays the role of an adhesive in the acupuncture patch. The traditional Chinese medicine composition for treating cancer pain can also be wrapped in the Babu plaster matrix to play the role of sealing, protecting, coating, isolating moisture, and preventing the traditional Chinese medicine composition for treating cancer pain from deteriorating. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0033] Figure 1 A flow chart showing a method for preparing a traditional Chinese medicine acupuncture patch for treating cancer pain provided in an embodiment of the present application is shown. DETAILED DESCRIPTION

[0034] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0035] The embodiments of the present application provide a Chinese medicine composition for treating cancer pain, a Chinese medicine acupoint patch and a preparation method thereof, which are used to provide a safe and effective external medicine to relieve cancer pain in patients with malignant tumors and improve their quality of life, and have advantages in effectiveness, safety, tolerability and compliance.

[0036] In order to illustrate the technical solution described in this application, a specific embodiment is provided below for illustration. Example 1

[0037] This embodiment provides a Chinese medicine composition for treating cancer pain, which is composed of the following raw materials in parts by weight:

[0038] 30-60 parts by weight of Gleditsia sinensis spines, 15-30 parts by weight of Curcuma zedoaria, 15-30 parts by weight of Tripterygium wilfordii, 5-10 parts by weight of dried ginger, 10-20 parts by weight of Angelica dahurica, 3-6 parts by weight of Carthamus tinctorius, 5-10 parts by weight of Eupolyphaga sinensis, 5-10 parts by weight of Pheretima lumbricoides, and 3-6 parts by weight of Panax notoginseng.

[0039] In some embodiments, the Chinese medicine composition is composed of the following raw materials in parts by weight:

[0040] 30 parts by weight of Gleditsia sinensis, 15 parts by weight of Curcuma zedoaria, 15 parts by weight of Tripterygium wilfordii, 5 parts by weight of dried ginger, 10 parts by weight of Angelica dahurica, 3 parts by weight of Carthamus tinctorius, 5 parts by weight of Eupolyphaga sinensis, 5 parts by weight of Pheretima lumbricoides, and 3 parts by weight of Panax notoginseng

[0041] As an example, the mass ratio of Gleditsia sinensis, Trigonella ternata and Curcuma zedoaria is 2:1:1. Example 2

[0042] This embodiment provides a traditional Chinese medicine acupuncture patch for treating cancer pain, which is composed of a Babu plaster base and the above-mentioned traditional Chinese medicine composition. Example 3

[0043] See also Figure 1 As shown, this embodiment provides a method for preparing a Chinese medicine acupuncture patch for treating cancer pain, comprising the following steps:

[0044] (1) Prepare raw materials:

[0045] Weigh the medicinal materials according to the following proportions: 30-60 parts by weight of Gleditsia sinensis, 15-30 parts by weight of Curcuma zedoaria, 15-30 parts by weight of Tripterygium wilfordii, 5-10 parts by weight of dried ginger, 10-20 parts by weight of Angelica dahurica, 3-6 parts by weight of Carthamus tinctorius, 5-10 parts by weight of Eupolyphaga sinensis, 5-10 parts by weight of Pheretima lumbricoides, and 3-6 parts by weight of Panax notoginseng.

[0046] As an example, the mass ratio of Gleditsia sinensis, Trigonella ternata and Curcuma zedoaria is 2:1:1.

[0047] As an example, 30 parts by weight of Gleditsia sinensis, 15 parts by weight of Curcuma zedoaria, 15 parts by weight of Tripterygium wilfordii, 5 parts by weight of dried ginger, 10 parts by weight of Angelica dahurica, 3 parts by weight of Carthamus tinctorius, 5 parts by weight of Eupolyphaga sinensis, 5 parts by weight of Pheretima lumbricoides, and 3 parts by weight of Panax notoginseng;

[0048] Sodium polyacrylate, polyvinyl pyrrolidone, aluminum glycolate, disodium ethylenediaminetetraacetic acid, tartaric acid and glycerin are taken as raw materials of the Babu cream base.

[0049] (2) Preparation of thick paste:

[0050] Soak dried ginger, Gleditsia sinensis thorns, Angelica dahurica, safflower, Eupolyphaga sinensis, Curcuma zedoaria and Trillium in water until thoroughly moistened, then boil and extract, collect the extract, and concentrate under reduced pressure to obtain a thick paste.

[0051] (3) Preparation of ultrafine powder:

[0052] The earthworm and Panax notoginseng are dried, ultrafinely crushed, and sieved to obtain ultrafine powder of Panax notoginseng and earthworm.

[0053] (4) Preparation of acupoint stickers:

[0054] Disperse sodium polyacrylate, disodium ethylenediaminetetraacetic acid and aluminum glycolate in glycerol as phase A; take purified water, add polyvinyl pyrrolidone and tartaric acid in sequence, and add thick paste and ultrafine powder as phase B after they are fully dissolved; add phase B into phase A in small amounts several times, stir evenly to form an ointment, quickly apply it on the backing material, and leave it to dry and form at room temperature to obtain a traditional Chinese medicine acupuncture patch.

[0055] The above embodiments provide a Chinese medicine composition for treating cancer pain, a Chinese medicine acupoint patch and a preparation method thereof, which have the effects of promoting blood circulation and removing blood stasis, dispersing nodules and eliminating symptoms, and unblocking meridians and relieving pain. The acupoint patch is easy to use and has good patient compliance. Example 4

[0056] In order to verify the beneficial effects of the above-mentioned Chinese medicine acupoint patch, this application also provides the following experimental related data.

[0057] 1. As one of the complications of patients with advanced cancer, cancer pain is one of the biggest factors affecting the efficacy of anti-tumor treatment and the quality of life of cancer patients. Modern medicine's treatment methods for advanced cancer pain are nothing more than three types of drugs: non-steroidal anti-inflammatory drugs, weak opioids, and strong opioids. However, these treatment methods are prone to drug resistance, and even some drugs are prone to dependence. Based on these factors, patients' compliance is relatively poor. Therefore, there is an urgent need for a safe, effective, and comprehensive treatment method to effectively treat cancer pain and greatly increase the compliance of the majority of cancer patients and their families. Traditional Chinese medicine has a complete set of theoretical foundations for the treatment of "pain". Traditional Chinese medicine believes that "pain occurs when there is no circulation" and "pain occurs when there is no nourishment", and cancer pain is no exception. In the advanced stage of cancer, the evil toxins condense for a long time, and it is stubborn and difficult to eliminate, resulting in the condensation of qi and blood, which causes pain; the obstruction of qi, blood, and body fluids, and the inability of tissues and organs to nourish also cause pain. Therefore, TCM takes "tong" and "rong" as the treatment principles, and treats pain through oral Chinese medicine, external plasters, acupuncture, moxibustion, cupping, massage and other means, with very good results. Based on the above theory, by consulting a large number of relevant literature, it is found that since it is inconvenient for patients to take Chinese medicine decoctions, and the compliance is poor due to the morning and evening decoctions, in order to increase the analgesic effect and facilitate carrying, it is extracted through technology to make it into a plaster.

[0058] 2. Implement clinical drug experimental plan

[0059] 2.1 A total of 81 cancer patients diagnosed with cancer pain and chronic intractable pain from the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine were selected.

[0060] 2.2 Diagnostic criteria: refer to the Guidelines for Diagnosis and Treatment of Cancer Pain (2018 Edition).

[0061] 2.3 Inclusion criteria: cancer patients who meet the diagnostic criteria; aged 10-90 years; expected survival period greater than 3 months; KPS score ≥ 60 points; patients voluntarily participate in the study, sign the informed consent form, and have high compliance; the patient or the agent can read, understand, and fill in the questionnaire.

[0062] 2.4 Exclusion criteria:

[0063] Patients with severe bleeding tendency; patients with diseases of the digestive system, blood system, urinary system, liver, kidney and other important organs; patients with other malignant tumors; patients with severe infectious diseases who need concurrent treatment; patients who are pregnant, breastfeeding or have mental illness; patients taking concomitant medications (recombinant human granulocyte colony stimulating factor, thymosin, interleukin, erythropoietin).

[0064] 2.5 Exit criteria: serious violation of the clinical trial protocol; rapid deterioration of the condition, high risk of dangerous events, requiring immediate termination of the trial; serious adverse events, making it difficult to continue the trial; requesting termination of the trial; incomplete data; other reasons determined by the investigator to be unable to continue the trial.

[0065] 2.6 Treatment options

[0066] (1) Control group: Patients received only standard Western medical treatment during the same period and did not receive Chinese medicine treatment, including Chinese medicine decoctions, decoction-free granules, oral and injectable Chinese patent medicines with similar efficacy, etc.

[0067] (2) Experimental group: treated with Chinese medicine patch on the basis of the control group. Use the acupoint patch of the present invention once a day (each piece of ointment weighs 5 g and the application radius is 1.5 cm). Select the acupoints: Ashi point, Zusanli, Yongquan, Guanyuan, Qihai, Tanzhong, Sanyinjiao, Jiaji points (selected according to the specific conditions of the patient). The application time is more than 6-8 hours, usually before going to bed, removed in the morning, and observed for 1 week.

[0068] 2.7 Observation indicators and efficacy evaluation criteria

[0069] (1) Clinical symptoms: The pain numerical rating scale (NRS) score changes, TCM syndrome scoring table, and KPS were used to evaluate the patients' quality of life before and after treatment;

[0070] (2) Clinical efficacy: After treatment, the analgesic effect of the observation group and the control group was evaluated according to the Oncology Volume. The total analgesic efficacy was calculated as follows: (complete remission + partial remission + mild remission) number of cases / total number of cases × 100%.

[0071] According to the numberic rating scales (NRS), if the patient has no pain after treatment, it is scored as 0 points, which is considered complete relief; if the patient's pain is significantly relieved after treatment, and the NRS score decreases by 50% < 75%, it is considered partial relief; if the patient's pain is alleviated after treatment, and the NRS score decreases by ≤ 50%, it is considered mild relief; those who fail to meet the above standards after treatment are considered ineffective.

[0072] 2.8 Safety evaluation

[0073] During the treatment, the patients' blood routine indexes, liver function and kidney function indexes were observed.

[0074] 2.9 Statistical analysis

[0075] SPSS 21.0 software was used for statistical analysis, and chi-square test was used for count data; For data of different levels, t-test or paired t-test was used; for data of different levels, rank sum test was used. All hypothesis tests were two-sided, and P < 0.05 was considered statistically significant.

[0076] 3. Experimental results

[0077] 3.1 Comparison of baseline data

[0078] The chi-square test and two independent sample t-tests showed that there was no statistically significant difference in gender and age between the two groups (P>0.05). See Table 1 and Table 2 for details.

[0079] Table 1 Comparison of gender between the two groups

[0080]

[0081] Table 2 Comparison of age between the two groups

[0082]

[0083] 3.2 Comparison of clinical efficacy between the two groups before and after treatment

[0084] After one cycle of treatment, the total analgesic efficacy of the experimental group (97.50%) was higher than that of the control group (26.83%), and the difference was statistically significant (P < 0.05). See Table 3.

[0085] Table 3 Clinical efficacy evaluation of the two groups of patients

[0086]

[0087] 3.3 Comparison of NRS, KPS, and TCM syndrome scores between the two groups before and after treatment

[0088] Before treatment, there were no significant differences in NRS scores, KPS scores, and TCM syndrome scores between the two groups (P>0.05). After treatment, the NRS scores of the experimental group were lower than those of the control group, and the difference was statistically significant (P<0.05).

[0089] Compared with before treatment, the NRS and TCM syndrome scores of the two groups of patients decreased after treatment (P<0.05), and there was no significant difference in KPS scores (P>0.05). See Table 4 for details.

[0090] Table 4 Comparison of NRS, KPS and TCM syndrome scores between the two groups before and after treatment

[0091]

[0092] Among them, a in Table 4 means that the difference between the treatment group and the experimental group is P<0.05.

[0093] 3.4 Safety evaluation

[0094] During the trial, blood, liver and kidney function tests were performed before and after treatment in both groups to evaluate the safety of the drug. Before treatment, there was no significant difference in the number of red blood cells (RBC), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatinine (Cr) between the two groups (P>0.05). Compared with before treatment, there was no significant difference in the RBC, WBC and Cr values ​​between the two groups after treatment (P>0.05). After treatment, the ALT and AST of the patients in the experimental group decreased, and the difference was statistically significant (P<0.05). Test results: No normal results before treatment and abnormal results after treatment were found, indicating that the tumor-eliminating and analgesic ointment is safe. See Table 5 and Table 6 for details.

[0095] Table 5 Comparison of RBC and WBC scores between the two groups before and after treatment

[0096]

[0097] Among them, b in Table 5 means that the comparison between the results before and after treatment in the same group (control group or experimental group) is P>0.05.

[0098] Table 6 Comparison of ALT, AST and CR scores between the two groups before and after treatment

[0099]

[0100] Among them, a in Table 6 means that the difference between the treatment group and the pre-treatment group is P<0.05; b means that the difference between the treatment group and the pre-treatment group is P>0.05.

[0101] The embodiments described above are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned embodiments, a person skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. Such modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present application, and should all be included in the protection scope of the present application.

Claims

1. A Chinese medicine composition for treating cancer pain, characterized in that: It is composed of the following raw materials in parts by weight: 30-60 parts by weight of Gleditsia sinensis spines, 15-30 parts by weight of Curcuma zedoaria, 15-30 parts by weight of Tripterygium wilfordii, 5-10 parts by weight of dried ginger, 10-20 parts by weight of Angelica dahurica, 3-6 parts by weight of Carthamus tinctorius, 5-10 parts by weight of Eupolyphaga sinensis, 5-10 parts by weight of Pheretima lumbricoides, and 3-6 parts by weight of Panax notoginseng.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 30 parts by weight of Gleditsia sinensis, 15 parts by weight of Curcuma zedoaria, 15 parts by weight of Tripterygium wilfordii, 5 parts by weight of dried ginger, 10 parts by weight of Angelica dahurica, 3 parts by weight of Carthamus tinctorius, 5 parts by weight of Eupolyphaga sinensis, 5 parts by weight of Pheretima lumbricoides, and 3 parts by weight of Panax notoginseng.

3. The Chinese medicine composition according to claim 1, characterized in that The mass ratio of the Gleditsia sinensis thorns, the Tripterygium wilfordii and the Curcuma zedoaria is 2:1:

1.

4. A Chinese medicine acupuncture patch for treating cancer pain, characterized in that: The invention is composed of a Babu paste base and the traditional Chinese medicine composition according to any one of claims 1 to 3.

5. A method for preparing a Chinese medicine acupuncture patch for treating cancer pain, characterized in that: include: (1) Prepare raw materials: Weigh the following medicinal materials according to the following proportions: 30-60 parts by weight of Gleditsia sinensis, 15-30 parts by weight of Curcuma zedoaria, 15-30 parts by weight of Tripterygium wilfordii, 5-10 parts by weight of Dried Ginger, 10-20 parts by weight of Angelica dahurica, 3-6 parts by weight of Carthamus tinctorius, 5-10 parts by weight of Eupolyphaga sinensis, 5-10 parts by weight of Pheretima lumbricoides, and 3-6 parts by weight of Panax notoginseng; Sodium polyacrylate, polyvinyl pyrrolidone, aluminum glycolate, disodium ethylenediaminetetraacetate, tartaric acid and glycerin are used as raw materials of the Babu ointment base; (2) Preparation of thick paste: Soak the dried ginger, the thorn of Gleditsia sinensis, the angelica dahurica, the safflower, the earthworm, the zedoaria, and the trifoliate vine in water until they are thoroughly moistened, then boil and extract, collect the extract, and concentrate under reduced pressure to obtain a thick paste; (3) Preparation of ultrafine powder: Drying the earthworm and the Panax notoginseng, ultrafine grinding, and sieving to obtain ultrafine powder of Panax notoginseng and earthworm; (4) Preparation of acupoint stickers: Disperse the sodium polyacrylate, disodium ethylenediaminetetraacetate and aluminum glycolate in the glycerol as phase A; separately take purified water, add the polyvinyl pyrrolidone and tartaric acid in sequence, and add the thick paste and the ultrafine powder as phase B after they are fully dissolved; add the phase B into the phase A in small amounts and multiple times, stir evenly to form an ointment, quickly apply it on a backing material, and leave it to dry and form at room temperature to obtain a traditional Chinese medicine acupuncture patch.

6. The preparation method according to claim 5, characterized in that: (1) When preparing the raw materials, weigh the medicinal materials according to the following proportions: 30 parts by weight of Gleditsia sinensis, 15 parts by weight of Curcuma zedoaria, 15 parts by weight of Tripterygium wilfordii, 5 parts by weight of dried ginger, 10 parts by weight of Angelica dahurica, 3 parts by weight of Carthamus tinctorius, 5 parts by weight of Eupolyphaga sinensis, 5 parts by weight of Pheretima lumbricoides, and 3 parts by weight of Panax notoginseng.

7. The preparation method according to claim 5, characterized in that: The mass ratio of the Gleditsia sinensis thorns, the Tripterygium wilfordii and the Curcuma zedoaria is 2:1:1.

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