Self-suction type in-vitro diagnostic reagent card

Abstract

The invention discloses a self-suction type in-vitro diagnostic reagent card, which belongs to the field of reagent cards, and comprises a body and a housing for mounting the body, the body comprises a sample area for contacting a detection sample, a binding area for binding with a sample mark, and a detection area for displaying aggregated precipitates, and the housing also comprises a support part, and the support component accelerates the combination and reaction of the samples through an air pressure mechanism arranged in the support component. According to the self-suction type in-vitro diagnostic reagent card, a novel negative-pressure self-suction type acceleration design is adopted, and an effective negative-pressure environment can be created through simple pressing operation, so that the detection efficiency is effectively improved on the basis of not influencing the combination of a sample and an antigen.

Description

Technical Field

[0001] The present invention relates to the technical field of reagent cards, in particular to testing materials by measuring the chemical properties of the materials, and specifically to a self-priming in vitro diagnostic reagent card. Background Art

[0002] Taking the coronavirus reagent card as an example, as one of the important means of in vitro diagnosis, the sample solution flows through the capillary flow in the sample layer to the binding area, and the characteristics of the combination of the coronavirus and its antigen are utilized to facilitate the use of the detection line of the detection area for color development. For example, a reagent card with the publication number CN114324753A in the prior art includes: a main body; a sample area, which is used to connect the container containing the sample to be tested; a first reagent area, in which a first reagent mixed with the sample to be tested is arranged, the first reagent area has a first liquid inlet and a first liquid outlet, and the first liquid inlet is connected to the sample area through a first liquid channel; a second reagent area, in which a stirring device is arranged in the second reagent area, the second reagent area is connected to the first liquid outlet of the first reagent area through a second liquid channel, and a first stop valve is arranged on the second liquid channel; a first gas channel, the first end of the first gas channel is connected to the first reagent area, and the second end of the first gas channel is a first negative pressure end; a second gas channel, the first end of the second gas channel is connected to the second reagent area, and the second end of the first gas channel is a second negative pressure end. The technical solution of the invention can effectively solve the problem of poor mixing effect of reagents and liquid samples in the related art.

[0003] Another example is an in vitro diagnostic analyzer and reagent card with a publication number of CN111257548B in the prior art. The reagent card includes a reagent card body and a mounting body. The mounting body includes a mounting hole for sleeve-connecting a sample tube, a hollow needle arranged in the mounting hole, a sealing portion arranged in the mounting hole, and an air inlet channel. One end of the hollow needle can be inserted into the sample tube, and the sealing portion is sealed with the outer wall of the sample tube. The air inlet channel includes an air outlet, an air inlet arranged on the surface of the reagent card body, and a first flow-stopping structure arranged between the air outlet and the air inlet. The air outlet is used to communicate with the sample tube installed on the mounting hole; the reagent card body includes an injection channel, a detection cavity, and an air connection end that are connected to the liquid outlet end of the hollow needle, and the injection channel and the air connection end are connected to the detection cavity. The reagent card adopts a new on-off control scheme for the sample liquid, which can solve the hidden dangers of leakage and inability to extract the above-mentioned sample liquid. When the in vitro diagnostic analyzer is used, it is beneficial to improve the reliability of detection.

[0004] The above-mentioned existing technologies have made important technical improvements in improving the accuracy and reliability of detection, and some of the contents have high reference value in practical applications. However, some sample liquids cannot be further diluted to increase the detection efficiency. In the case of high concentration, the fluidity will be poor, affecting the detection efficiency. Therefore, this type of reagent card needs to be further improved and redesigned. Summary of the invention

[0005] The purpose of the present invention is to provide a self-priming in vitro diagnostic reagent card to solve the problem in the above background technology that part of the sample liquid cannot be further diluted to increase the detection efficiency, and high concentration will lead to poor fluidity, affecting the detection efficiency.

[0006] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a self-priming in vitro diagnostic reagent card, comprising a main body and a shell for installing the main body, wherein the main body includes a sample area for contacting and detecting a sample, a binding area for combining with a sample marker, and a detection area for aggregation and precipitation display, and the shell also includes a supporting component, which accelerates the binding and reaction of the sample through an internally arranged air pressure mechanism.

[0007] As a further feature, the support component includes a horizontal bar for fixing the body in the shell from below the body and in cooperation with the upper wall of the shell.

[0008] As a further feature, the air pressure mechanism includes air holes opened on the surface of the horizontal bar, and the air holes are inclined or vertically distributed toward the surface of the body, and the air holes are communicated with the air cavity opened inside the horizontal bar.

[0009] As a further feature, the air cavity is connected to a negative pressure mechanism, wherein the negative pressure mechanism is disposed inside the shell and produces an air pressure change effect through the sliding of an external handle.

[0010] As a further feature, the negative pressure mechanism includes a slide plate connected to the handle via a slide bar, wherein the outer surface of the slide plate is connected to the first airbag in the negative pressure mechanism, and the inner surface of the slide plate is also connected to the second airbag.

[0011] As a further feature, the first airbag is connected to the air cavity via a first air tube.

[0012] As a further feature, the second airbag is deformed synchronously with the movement of the slide plate, and the deformation direction is opposite to that of the first airbag.

[0013] As a further feature, the second air bag is communicated with the second air tube, and the second air tube is communicated with the internal air cavity of the horizontal bar located above the main body in the shell.

[0014] As a further feature, the horizontal strip above the detection area is disconnected, and the air cavity cutouts exposed at the disconnected locations are distributed in an inclined, vertical or horizontal direction toward the upper surface of the detection area.

[0015] The beneficial effect of the present invention is that the self-priming in vitro diagnostic reagent card adopts a new negative pressure self-priming acceleration design, which can effectively create a negative pressure environment through a simple pressing operation, thereby effectively improving the detection efficiency without affecting the binding of samples and antigens, as shown in the following content.

[0016] 1. The structural design of the horizontal bar under the main body can, on the one hand, provide stable support and positioning for the reagent card, and on the other hand, cooperate with the air cavity with negative pressure effect generated inside it and the suction effect generated by the air holes set on its surface to accelerate the infiltration of the sample solution from the bottom of the reagent card, thereby increasing the speed and comprehensiveness of its reaction with the antigen, and then cooperate with the capillary action to improve the overall detection efficiency of the reagent card for the sample.

[0017] 2. The slide plate is combined with the slide bar and the handle structure design on the outside of the shell, which allows users to achieve the effect of providing a negative pressure environment by simply pressing and releasing the operation: through the movement of the slide plate and the deformation of the airbag guided by it, the suction hole under the body can be in a negative pressure state while waiting for the reaction. There is no need to use other complex principle solutions, the cost is low and the effect is excellent; Furthermore, the use of the second airbag allows the movement of the slide plate to synchronously pull the deformation of the second airbag and produce an air pressure regulation effect that is completely opposite to that of the first airbag in the same stroke. Therefore, during the reaction of the sample solution, the self-priming below the main body and the pressurization above the main body can be used simultaneously to produce better acceleration and improve accuracy. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 This is a schematic diagram of the internal structure of Embodiment 1 of the present invention; Figure 3 This is a schematic diagram of the main body distribution structure of the present invention; Figure 4 This is a schematic diagram of the internal structure of the horizontal bar of the present invention; Figure 5 This is a schematic diagram of the horizontal strip distribution structure at the combination area of ​​the present invention; Figure 6 This is a schematic diagram of the horizontal strip distribution structure at the detection area of ​​the present invention; Figure 7 This is a schematic diagram of the overall structure of Embodiment 2 of the present invention; Figure 8 For the present invention Figure 7 Schematic diagram of the internal structure.

[0019] In the figure: 1. main body; 2. outer shell; 3. sample area; 4. combining area; 5. detection area; 6. horizontal bar; 7. air cavity; 8. air hole; 9. handle; 10. slide bar; 11. slide plate; 12. first air bag; 13. first air pipe; 14. second air bag; 15. second air pipe. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] See also Figure 1-Figure 8 , the present invention provides the following technical solutions: Embodiment 1: The solution disclosed in this embodiment is to solve the problems existing in the prior art and effectively increase the speed of sample-antibody binding while improving accuracy. The specific solution is to provide a negative pressure environment from the bottom of the body 1, thereby accelerating the capillary reaction and infiltration of the sample liquid in different functional areas, thereby increasing the binding speed. Figure 1-Figure 4 As shown, it includes a body 1 and a shell 2 for mounting the body 1, and the body 1 includes a sample area 3 for contacting and detecting a sample, a binding area 4 for combining with a sample mark, and a detection area 5 for displaying aggregated precipitation. The shell 2 also includes a supporting component, and the supporting component accelerates the binding and reaction of the sample through an internally arranged air pressure mechanism. The supporting component includes a horizontal bar 6 for fixing the body 1 in the shell 2 from the bottom of the body 1 and cooperating with the upper wall of the shell 2. The air pressure mechanism includes air holes 8 opened on the surface of the horizontal bar 6, and the air holes 8 are inclined or vertically distributed toward the surface of the body 1. At the same time, the air holes 8 It is connected to the air cavity 7 opened in the horizontal bar 6, wherein the function of the supporting component, that is, the horizontal bar 6 itself, is to support the main body 1 from the bottom and to stably install the main body 1 in the shell 2 in combination with the upper shell 2. After the corresponding air pressure mechanism is set in the horizontal bar 6, the negative pressure effect generated by the air holes 8 below the main body 1 can be used. When the main body 1 is close to or close to the air holes 8 below, the sample solution in the corresponding functional area can fully react and realize the corresponding function under the condition of accelerated infiltration, and at the same time cooperate with the capillary adsorption effect of the main body 1 to accelerate the overall function of the reagent card.

[0022] Embodiment 2: In this embodiment, the following scheme is specifically disclosed, such as Figure 4-Figure 8As shown in the figure, the air cavity 7 is connected to the negative pressure mechanism, wherein the negative pressure mechanism is arranged inside the housing 2 and produces an air pressure change effect by sliding the external handle 9, and the negative pressure mechanism includes a slide plate 11 connected to the handle 9 through a slide bar 10, wherein the outer surface of the slide plate 11 is connected to the first air bag 12 in the negative pressure mechanism, and the inner surface of the slide plate 11 is also connected to the second air bag 14, and the first air bag 12 is connected to the air cavity 7 through a first air tube 13. When the user drips the sample liquid, he can press the handle 9 with one hand. During the pressing process, the handle 9 drives the slide plate 11 to slide inside the housing 2 through the slide bar 10. In this sliding direction, the first air bag 12 is in a compressed state, so after releasing the handle 9, the first air bag 12 The slow or fast rebound will cause the first air tube 13 to be in a negative pressure state. At the same time, under the connection between the first air tube 13 and the air cavity 7, the air cavity 7 and the air hole 8 connected thereto will be in a continuous negative pressure state at the same time, thereby realizing the self-priming rapid response function of the sample liquid in the main body 1 and the corresponding functional area on the main body 1. At the same time, since the two-way output inlet and outlet of the first air bag 12 in this solution are both connected to the first air tube 13, before dripping the sample liquid, the user can also repeatedly press the handle 9 to make the first air bag 12 repeatedly deform and repeatedly generate positive and negative pressure effects, thereby performing auxiliary pre-cleaning of the reagent card itself, thereby avoiding false positive samples caused by impurities that may exist on the surface of the reagent card.

[0023] The solution disclosed in this embodiment is to cooperate with the self-priming effect to further accelerate the reaction speed in the reagent card. The specific form is as follows Figure 4-Figure 8 As shown, the second airbag 14 is deformed synchronously with the movement of the slide plate 11, and the deformation direction is opposite to that of the first airbag 12. The second airbag 14 is connected to the second air pipe 15, and the second air pipe 15 is connected to the air cavity 7 inside the horizontal bar 6 located above the main body 1 in the shell 2. The horizontal bar 6 above the detection area 5 is disconnected, and the cutout of the air cavity 7 exposed at the disconnection is distributed in an inclined or vertical or horizontal direction toward the upper surface of the detection area 5. When the slide plate 11 is moving, it will also synchronously pull the second airbag 14 to deform, and when the airbag is deformed, it will be connected to the second air pipe 15 to the upper surface of the main body 1. The air pressure in the air cavity 7 inside the horizontal bar 6 is adjusted, and the adjustment direction is opposite to that of the first air bag 12. That is to say, when the user presses and releases the handle 9, the slow or fast movement of the slide plate 11 will guide the first air bag 12 to stretch and deform, thereby generating a negative pressure effect, and the second air bag 14 will be synchronously squeezed and deformed to generate a positive pressure conveying effect of the airflow. That is to say, the bottom of the main body 1 is in a negative pressure state and the top is in a positive pressure airflow blowing state, so the functions of different functional areas in the main body 1 will be played more quickly, and at the same time, it also avoids the rapid horizontal flow of the sample solution and the untimely response, resulting in the occurrence of false results in the detection area 5.

[0024] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A self-priming in vitro diagnostic reagent card, comprising a body (1) and a housing (2) for mounting the body (1), wherein the body (1) comprises a sample area (3) for contacting a test sample, a binding area (4) for binding with a sample marker, and a detection area (5) for displaying aggregated precipitation, characterized in that: The housing (2) also includes a supporting component, which accelerates the binding and reaction of the sample through an internally arranged air pressure mechanism.

2. A self-priming in vitro diagnostic reagent card according to claim 1, characterized in that: The supporting component comprises a horizontal bar (6) for fixing the body (1) in the outer shell (2) from below the body (1) and in cooperation with the upper wall of the outer shell (2).

3. A self-priming in vitro diagnostic reagent card according to claim 2, characterized in that: The air pressure mechanism comprises air holes (8) formed on the surface of the horizontal bar (6), and the air holes (8) are inclined or vertically distributed toward the surface of the body (1), and the air holes (8) are connected to the air cavity (7) formed inside the horizontal bar (6).

4. A self-priming in vitro diagnostic reagent card according to claim 3, characterized in that: The air cavity (7) is connected to a negative pressure mechanism, wherein the negative pressure mechanism is arranged inside the housing (2) and generates an air pressure change effect through the sliding of an external handle (9).

5. A self-priming in vitro diagnostic reagent card according to claim 4, characterized in that: The negative pressure mechanism comprises a slide plate (11) connected to a handle (9) via a slide rod (10), wherein an outer surface of the slide plate (11) is connected to a first air bag (12) in the negative pressure mechanism, and an inner surface of the slide plate (11) is also connected to a second air bag (14).

6. A self-priming in vitro diagnostic reagent card according to claim 5, characterized in that: The first air bag (12) is connected to the air cavity (7) via the first air tube (13).

7. A self-priming in vitro diagnostic reagent card according to claim 5, characterized in that: The second airbag (14) deforms synchronously with the movement of the slide plate (11), and the deformation direction is opposite to that of the first airbag (12).

8. A self-priming in vitro diagnostic reagent card according to claim 7, characterized in that: The second air bag (14) is connected to the second air pipe (15), and the second air pipe (15) is connected to the air cavity (7) inside the horizontal bar (6) located above the main body (1) in the outer shell (2).

9. A self-priming in vitro diagnostic reagent card according to claim 8, characterized in that: The horizontal strip (6) above the detection area (5) is disconnected, and the cutout of the air cavity (7) exposed at the disconnection position is distributed in an inclined, vertical or horizontal direction toward the upper surface of the detection area (5).

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