Powder composition, composition food for masking bitterness of medicaments, method for masking bitterness of medicaments, and

Abstract

The present invention relates to a powder composition which can exhibit a masking effect and can be made into a foamed food having excellent dispersibility in an aqueous solvent. The powder composition is a powder composition for mixing with water to make a foamed food. The powder composition contains the following components (A) to (D). (A) is a saccharide, (B) is an acid component, (C) is a carbonic acid component, and (D) is a foam stabilizer.

Description

Technical Field

[0001] The present invention relates to a powder composition that can exert a masking effect and can be made into a foam-like food having excellent dispersibility in an aqueous solvent. More specifically, the present invention relates to a powder composition that can mask the bitterness of a drug and ensure the dissolution of the drug when the drug is contained in a foam-like food related to the powder composition of the present invention and taken, a combined food for masking the bitterness of a drug, and a method for masking the bitterness of a drug. Background Art

[0002] As a powder composition for preparing a food that is foamed and expanded by adding water and mixing, the inventors and others proposed a combination snack (confectionery) (for example, refer to patent document 1) and a powder composition (for example, refer to patent document 2). With respect to the combination snack, changes in physical properties and appearance can be expected, and the changes in physical properties and appearance are caused by contacting the powder composition used for the paste with water, and the more it is kneaded, the more it foams, and the paste expands and becomes turbid. In addition, with respect to the powder composition, visual changes can be expected, and the visual changes are instantaneous and uniform foaming and expansion when a liquid component is added. That is, while expecting the powder composition to foam and expand, such as a water mixing process, the foamy food is prepared and directly ingested (eaten). However, there is no disclosure of including a medicament in the foamy food for taking or masking the bitterness of the medicament.

[0003] On the other hand, a foam composition is known, wherein the foam composition contains a foam stabilizer of polymer (ポリマー), a non-fibrous (non-セルロース) polysaccharide, and a pharmaceutical active ingredient, and is used to mask the bitter taste or unpleasant taste of a pharmaceutical active agent or a nutritional supplement (for example, with reference to patent document 3). The foam composition is prepared by drying after being vigorously stirred by a foam generating device such as a mixer or a foam generator to form a foam. In addition, a coated medicine is used to protect the pharmaceutical active ingredient when preparing foam or a foam composition. Further, in the case of applying the pharmaceutical active ingredient after the foam composition is first prepared, for example, for the dried foam composition, nicotine can be applied to the surface of the foam composition using a solvent such as acetone. Therefore, no matter which method is used, there is a problem in terms of simplicity for masking bitter medicines for the ingestor.

[0004] In addition, when taking bitter medicines, etc., known medication supplements for masking the bitter taste include bitter-masking granular frozen drinks (for example, see Patent Document 4), powder compositions made into gel-like foods by adding water (for example, see Patent Document 5), and medication supplements made of chocolate whose viscosity is controlled to be in the range of 50 poise to 500 poise in the temperature range of 10°C to 40°C (for example, see Patent Document 6).

[0005] However, when the granular frozen beverage or the powder composition is used to take medicine, it may taste bitter and a stable masking effect may not be obtained. In addition, the medicine-taking aid made of chocolate has poor dispersibility in an aqueous solvent, so it is difficult to measure the dissolution of the medicine according to the dissolution test of the Japanese Pharmacopoeia (Japanese Pharmacopoeia). Prior art literature Patent Literature

[0006] [Patent Document 1] Japanese Utility Model Publication No. 03-33274 [Patent Document 2] Japanese Patent Application Laid-Open No. 06-237696 [Patent Document 3] Japanese Patent Application Publication No. 2000-325028 [Patent Document 4] International Publication No. 2005 / 025622 [Patent Document 5] Japanese Patent Application Publication No. 2012-105574 [Patent Document 6] Japanese Patent Application Publication No. 2017-48169 Summary of the invention Technical Problems to be Solved by the Invention

[0007] The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a powder composition that can exert a masking effect and can be made into a foamed food having excellent dispersibility in an aqueous solvent.

[0008] More specifically, the present invention provides a powder composition that can mask the bitterness of a drug and ensure the solubility of the drug if the drug is contained in a foamy food related to the powder composition of the present invention and taken, a combination food for masking the bitterness of a drug, and a method for masking the bitterness of a drug. Technical means to solve technical problems

[0009] The present inventors have focused on foamy foods as candidates for supplementary foods for taking medicines that have a masking effect and excellent dispersibility in aqueous solvents, and have conducted intensive research. As a result, they have found that if a powder composition containing sugars, an acid component, a carbonic acid component, and a foam stabilizer is mixed with water to prepare a foamy food, it is possible to achieve the effect of encapsulating a medicine for taking, masking the bitterness of the medicine, and having good dispersibility in an aqueous solvent, masking the bitterness of the medicine, especially strongly masking the bitterness immediately after taking the medicine, and ensuring the dissolution of the medicine, thereby completing the present invention.

[0010] The first invention of the present application is a powder composition which is used to be mixed with water to form a foamed food, and the powder composition contains the following components (A) to (D). (A) Sugar (B) Acid component (C) Carbonic acid component (D) Foam stabilizer

[0011] It is preferred that the powder composition of the first invention of the present application further contains the following component (E). (E) Masking components In the powder composition of the first invention of the present application, it is more preferable that the specific gravity of the foamed food is 0.83 g / cc or less. In the powder composition of the first invention of the present application, it is further preferred that the foamy food is a foamy food for wrapping a medicine for ingestion.

[0012] The second invention of the present application is a combination food for masking the bitter taste of a drug, wherein the combination food comprises: the powder composition and (X) a container having two layers of recesses in the shape of an inverted mirror cake.

[0013] The third invention of the present application is a method for masking the bitter taste of a drug, wherein the method comprises: adding water to a powder composition containing sugar, an acid component, a carbonic acid component, and a foam stabilizer to mix to prepare a foamy food, and mixing the drug into the obtained foamy food.

[0014] The fourth invention of the present application is a use of a powder composition, wherein the use is for mixing the powder composition with water to make a foamy food, and wrapping a medicine in the foamy food for ingestion, and the powder composition contains the following ingredients (A) to (D). (A) Sugar (B) Acid component (C) Carbonic acid component (D) Foam stabilizer

[0015] The fifth invention of the present application is a method for using a powder composition, wherein the method comprises: adding water to the powder composition to obtain a foamy food, and wrapping a medicine in the foamy food and taking it, wherein the powder composition contains the following ingredients (A) to (D). (A) Sugar (B) Acid component (C) Carbonic acid component (D) Foam stabilizer Beneficial Effects

[0016] The foamed food obtained by mixing the powder composition of the present invention with water has a stable masking effect. Furthermore, if the powder composition of the present invention is mixed with water to prepare a foamed food, a foamed food having a masking effect exceeding that of conventional supplementary food for medication can be obtained.

[0017] The foamed food prepared using the powder composition of the present invention has excellent dispersibility in an aqueous solvent, and therefore, even when a drug is contained in the foamed food, a dissolution test can be carried out according to the method in accordance with the Japanese Pharmacopoeia. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] [ Figure 1 ] Schematic diagram showing how the bitter taste of a drug is masked. [ Figure 2 ](a) and (b) are diagrams showing an example of a container provided in the combination food according to the present embodiment. [ Figure 3 ] is a graph showing the dissolution test results of acetaminophen obtained from the dissolution test of the example. [ Figure 4 ] is a graph showing the dissolution test results of prednisolone obtained by the dissolution test in Examples. [ Figure 5 ] is a graph showing the dissolution test results of furosemide obtained from the dissolution test in Examples. [ Figure 6 ] is a graph showing the dissolution test results of metronidazole obtained in the dissolution test of Examples. [ Figure 7 ] The results of a questionnaire asking about prior purchase intention for the combination food of the present invention. [ Figure 8 ] (a) is a questionnaire result showing the masking effect of the combination food of the present invention on the ingestion. (b) is a questionnaire result showing the masking effect of the reference example on the ingestion. [ Fig. 9] (a) is a questionnaire result showing the ease with which the ingestion subjects take the bittering agent contained in the combination food of the present invention. (b) is a questionnaire result showing the ease with which the ingestion subjects take the bittering agent contained in the reference example. [ Fig.10 ] (a) is a questionnaire result showing the masking effect of the combination food of the present invention as perceived by the guardians. (b) is a questionnaire result showing the masking effect of the reference example as perceived by the guardians. [ Fig.11 ] (a) is a questionnaire result showing the difficulty of taking the bittering agent contained in the combination food of the present invention as felt by the guardians. (b) is a questionnaire result showing the difficulty of taking the bittering agent contained in the reference example as felt by the guardians. [ Fig.12 ] The results of a questionnaire asking about the purchase intention after using the combination food of the present invention. DETAILED DESCRIPTION

[0019] Hereinafter, the present invention will be described in detail.

[0020] (About powder composition) The powder composition of the present invention contains (A) a carbohydrate, (B) an acid component, (C) a carbonic acid component, and (D) a foam stabilizer, which is important for preparing a foamy food that exhibits a stable masking effect.

[0021] In this specification, “masking effect” means the effect of reducing the bitter taste produced by the binding of bitter substances to bitter receptors on the tongue, and “stable masking effect” means that the degree of bitterness reduction is reproducible when multiple people take it multiple times.

[0022] In the present specification, “containing a drug” means a state where the drug is contained in the foamed food, and the purpose is to reduce the surface exposure of the drug by mixing or encapsulating the drug in the foamed food.

[0023] In this specification, "dissolution of a drug" means the rate at which the active ingredient in the drug dissolves into the test solution of the dissolution test. In this embodiment, it means the rate at which the active ingredient in the drug dissolves into the test solution, and the drug is mixed or wrapped in a foamy food.

[0024] <(A) Sugar> The component (A) used in the present invention is a carbohydrate. In the present invention, the carbohydrate is used as a component of the base material of the foamed food. The carbohydrate is not particularly limited as long as it is a powdered sweetener. As the carbohydrate, specifically, for example, glucose, fructose, granulated sugar, maltose, lactose, oligosaccharides, dextrin, powdered maltose (powdered maltose), sugar alcohol, etc. can be cited. It can be appropriately selected from these and can be used alone or in combination of two or more. Among them, granulated sugar is suitable for use from the viewpoint of being able to exert an excellent masking effect and from the viewpoint of being able to give the foamed food a good flavor.

[0025] The sugar content is preferably 85.0% by weight or more of the total weight of the powder composition. If the sugar content is 85.0% by weight or more, a stable and high masking effect can be obtained from immediately after administration to swallowing.

[0026] <(B) Acid component> The (B) component used in the present invention is an acid component. In the present invention, the acid component acts as a proton donor of carbonate ions and is used for the purpose of generating carbon dioxide. As the acid component, for example, organic acids such as citric acid, tartaric acid, malic acid, ascorbic acid can be cited, which can be appropriately selected to be used alone or in combination with more than two kinds. Among them, from the viewpoint of being able to improve the masking effect, citric acid, tartaric acid, malic acid are suitable for use.

[0027] The acid content is preferably 0.4% by weight or more of the total weight of the powder composition. If the acid content is 0.4% by weight or more, sufficient bubbles (carbon dioxide) required for masking can be obtained, and further, the flavor of the foamed food can be improved.

[0028] <(C) Carbonic acid component> The (C) component used in the present invention is a carbonic acid component. The carbonic acid component is a carbonate that dissolves in water and releases carbonate ions. In the present invention, the carbonic acid component is used for the purpose of generating carbonate ions, which are precursors of carbon dioxide. As the carbonic acid component, for example, sodium bicarbonate, calcium carbonate, etc. can be cited, and they can be appropriately selected and used alone or in combination of two or more. Among them, sodium bicarbonate is suitable for use from the viewpoint of being able to improve the masking effect and the viewpoint of being able to further improve the flavor of the foamed food.

[0029] The content of the carbonic acid component in the total weight of the powder composition is preferably 0.4% by weight or more. When it is 0.4% by weight or more, bubbles (carbon dioxide) required for masking can be sufficiently obtained.

[0030] In addition, the weight ratio of the acid component (B) to the carbonic acid component (C) is preferably 1:0.25 to 4 (for example, see Examples 20 to 23). This allows bubbles (carbon dioxide) to be generated stably and effectively, and allows the preparation of a foamy food that can achieve a high masking effect. In addition, the weight ratio of the acid component (B) to the carbonic acid component (C) is more preferably 1:1. This allows the preparation of a foamy food with a low specific gravity.

[0031] <(D) Foam Stabilizer> The component (D) used in the present invention is a foam stabilizer. In the present invention, the foam stabilizer is used for the purpose of stabilizing the foam food (i.e., stably maintaining the structure of the foam food containing the drug). As the foam stabilizer, for example, egg white, soybean protein, Quillaja saponin (キラヤサポニン), sodium starch octenyl succinate, etc. can be cited, and they can be appropriately selected and used alone or in combination of two or more. Among them, from the viewpoint of being able to maintain the structure of the foam food and obtain a sufficient masking effect during the period from just after taking it to swallowing, and also being able to improve the flavor of the foam food, it is suitable to use Quillaja saponin and sodium starch octenyl succinate in combination.

[0032] The content of the foam stabilizer is preferably 1.3% by weight or more based on the total weight of the powder composition. If it is 1.3% by weight or more, a sufficient masking effect can be obtained during the period from immediately after administration to swallowing.

[0033] In addition, for the powder composition containing the components (A) to (D) of the present invention, it is important to add water and mix to form a foamy food in order to impart a stable masking effect. Here, "adding water and mixing" means adding water at room temperature (10° C. to 30° C.) to the powder composition for stirring and mixing. Furthermore, "foamy food" means a non-dried food in which bubbles are gathered. It is preferred to prepare a foamy food at the time of use when taking a medicine, etc.

[0034] It is believed that the foamed food prepared using the powder composition containing the components (A) to (D) of the present invention can reduce the chance of the active ingredient (bitter component) in the drug directly contacting the tongue when mixed with the drug. Figure 1 This is explained.

[0035] Figure 1 10 is a schematic diagram showing how the bitter taste of a medicine is masked, 11 is a foamy food containing a medicine, 12 is a bubble, and 13 is a medicine. T represents a human tongue, Figure 1 The inside of a human mouth is shown. Figure 1 In the embodiment, the foam food 11 has a foam structure in which a plurality of bubbles 12 are gathered. Figure 1As shown, in the foam food 10 containing medicine, the medicine 13 containing bitter ingredients is wrapped in the foam structure of the foam food 11, and the foam food 11 is prepared by using the powder composition of the present invention. It is speculated that when taken orally, the foam food 11 of the present invention exhibits the following effects (1) to (3), which can reduce the chance of the active ingredient (bitter ingredient) in the medicine 13 directly contacting the tongue, and can obtain a good masking effect. (1) The surface exposure of the drug 13 is suppressed by wrapping the foam structure of the foam food 11 (2) The high shape retention of the foamed food 11 inhibits the diffusion of the medicine 13 in the mouth (3) The low water content of the foamy food 11 inhibits the dissolution of the drug 13 in water.

[0036] <(E) Masking Component> The component (E) used in the present invention is a masking component. In the present invention, the masking component is suitable from the viewpoint of showing a higher masking effect not only immediately after taking but also during chewing and after swallowing. As masking components, for example, sugar cane extract, sucralose, thaumatin, erythritol, etc. can be cited, and they can be appropriately selected and used alone or in combination of two or more. Among them, sugar cane extract is suitable for use from the viewpoint of being able to exert a more excellent masking effect and from the viewpoint of being able to make the flavor of the foamed food better.

[0037] The content of the masking component in the total weight of the powder composition is preferably 0.7 wt % or more. If it is 0.7 wt % or more, adding the component (E) to the base material of the component (A) can achieve a higher masking effect not only immediately after taking but also during chewing and after swallowing.

[0038] In addition, as long as it does not damage the purpose of the present invention, auxiliary raw materials can also be added in addition to the above-mentioned components. As auxiliary raw materials, for example, starch, thickening polysaccharides, emulsifiers, spices, coloring materials, etc. can be cited. These can be appropriately selected to be used alone or in combination with more than two kinds.

[0039] The powder composition of the present invention is produced, for example, in the following manner. That is, first, (A) a saccharide, (B) an acid component, (C) a carbonic acid component, (D) a foam stabilizer, and (E) a masking component and auxiliary raw materials as required are prepared, and these are mixed in powder form to obtain the powder composition of the present invention.

[0040] (About foamy foods) The powder composition of the present invention is suitable for use as a foamy food, which is a foamy food for wrapping a drug when the drug is taken orally. Hereinafter, the foamy food obtained using the powder composition of the present invention will be described. For example, the foamy food can be prepared from the powder composition in the following manner.

[0041] First, 0.28 to 0.36 parts by weight of normal temperature water are added to 1 part by weight of the powder composition, and stirred and mixed for about 30 times at a speed of about 2 turns per second by a stirring utensil such as a spoon to obtain a foamy food. The specific gravity of the foamy food at this time is preferably below 0.83 g / cc. Thus, a foamy food with a higher masking effect can be obtained. In addition, it is more preferred to design the pH of the foamy food at this time to be 5.0 to 7.0, which is suitable from the viewpoint of preventing the dissolution of medicaments (antibiotics, etc.) that dissolve under acidic conditions.

[0042] Then, the minimum dosage of the medicine or the like is mixed and wrapped in the foamy food of 5.6 g to 6.9 g in a manner that the bubbles of the foamy food are not destroyed as much as possible, for example, using a small spoon such as a teaspoon, in a concentric circle at a speed of about 2 circles per second for about 10 circles. The foamy food containing the medicine prepared in this way is directly taken orally by the person who takes the medicine. In addition, the "containing" of the foamy food containing the medicine means that the medicine is contained in the foamy food. The purpose is to reduce the surface exposure of the medicine by mixing or wrapping the medicine in the foamy food.

[0043] As the drug, a drug taken by oral ingestion can be cited. As the form of the drug, tablets, capsules, granules, powders, oral liquids, syrups, oral gels, oral films, oral tablets, etc. can be cited. For example, as tablets, prednisolone tablets (such as "Prednisolone (registered trademark) tablets 5mg", etc.), metronidazole tablets (such as "Frakir (registered trademark) oral tablets 250mg", etc.) can be cited; as granules, acetaminophen granules (such as "Caronal (registered trademark) granules 20%, "Caronal (registered trademark) granules 50%, etc.), furosemide granules (such as "Furosemide granules 4% 'EMEC'", etc.) can be cited.

[0044] In addition, when preparing a foamed food, a container for adding water and mixing can be a suitable food container such as a plate or a tea bowl. In addition, a container having two layers of concave portions in a reverse mirror cake shape (reverse mirror cake shape) can be prepared in advance (X) to prepare a combined food containing a powder composition. This combined food is an example of a combined food for masking the bitter taste of a drug of the present invention.

[0045] That is, the combination food of this embodiment comprises the powder composition of one embodiment of the present invention described above and a container (X) having two-layer recessed portions in the shape of an inverted mirror cake. Figure 2 The appearance of one example (container 100 ) of the container (X) is shown.

[0046] Figure 2 (a) is a perspective view of the container 100. Figure 2 (b) is a plan view of the container 100. The container 100 is formed of, for example, relatively light plastic. The container 100 is composed of a body 110 and a spoon 120. A perforation line 130 is provided between the body 110 and the spoon 120. When the container 100 is used, the spoon 120 is separated from the body 110.

[0047] The main body 110 has a protrusion 111 that is protruded in a substantially truncated pyramid shape. A two-layer recess 112 in the shape of an inverted mirror cake is provided on the top surface 111a of the protrusion 111. When a foamed food is prepared using the combination food of this embodiment, a powder composition of materials that become the foamed food and water, and then a drug, are added into the two-layer recess 112. The capacity of the two-layer recess 112 can be appropriately determined in consideration of the amount of the powder composition contained in the combination food, the amount of water added, and the capacity of the foamed food to be formed.

[0048] The two-layer recessed part 112 has a first recessed part 113 and a second recessed part 114 (refer to Figure 2 (b)). The second recess 114 is formed by further digging out the bottom of the first recess 113. The depth of the second recess 114 from the bottom of the first recess 113 can be set to, for example, not less than 1 mm and not more than 5 mm. In addition, from the viewpoint of being able to prepare foamed food even without a measuring spoon described later, it is preferable to determine the depth of the second recess 114 in consideration of the volume of water put in when preparing foamed food. Furthermore, from the viewpoint of being able to maintain the strength of the main body 110, the side surface of the raised portion 111 is as shown in FIG. Figure 2 Forming a plurality of grooves 115 as shown is preferred.

[0049] The spoon 120 is used to stir the ingredients put into the two-layer recess 112 when preparing the foamed food. The spoon 120 is formed with a third recess 121. The capacity of the third recess 121 is preferably determined in consideration of the amount of water put in when preparing the foamed food. Thus, the spoon 120 can be used as a measuring spoon.

[0050] As described above, the combination food of this embodiment includes a powder composition and a container 100 having two layers of concave portions 112 in the shape of an inverted mirror cake. Thus, a foamed food and a foamed food containing a drug can be easily prepared using the container 100 included in the combination food without preparing a separate container.

[0051] In other embodiments, the container (X) may be formed only of the main body 110. In this case, as an accessory separate from the main body 110, a stirring spoon or the like is preferably included in the food combination.

[0052] (About the method of masking the bitter taste of medicine) The present invention includes a method for masking the bitter taste of a drug, the method comprising: adding water to a powder composition containing sugar, an acid component, a carbonic acid component, and a foam stabilizer to mix to prepare a foamed food, and mixing the drug into the obtained foamed food.

[0053] As the powder composition used in the method, the above-mentioned powder composition can be mentioned. In addition, as the foamed food obtained by adding water to the powder composition and mixing it, the above-mentioned foamed food can be mentioned. As the medicament mixed into the foamed food, the above-mentioned medicament can be mentioned. By this method, when the medicament containing the active ingredient (i.e., the bitter ingredient) is orally ingested, the chance of the bitter ingredient directly contacting the tongue can be reduced, thereby reducing the bitter taste felt by the ingestor and reducing the unpleasant feeling when taking it.

[0054] (About the use of powder composition) The present invention includes the use of a powder composition, which is used to add water to the powder composition to mix it to make a foamy food, and then wrap a medicine in the foamy food for taking.

[0055] As the powder composition for this purpose, the above-mentioned powder composition can be mentioned. In addition, as the foamed food obtained by adding water to the powder composition and mixing it, the above-mentioned foamed food can be mentioned. As the medicament mixed into the foamed food, the above-mentioned medicament can be mentioned. Through the use of the powder composition, when the medicament containing the active ingredient (i.e., the bitter ingredient) is orally ingested, the chance of the bitter ingredient directly contacting the tongue can be reduced, thereby reducing the bitter taste felt by the ingestor and reducing the unpleasant feeling when taking it.

[0056] (About how to use the powder composition) The invention includes a method for using a powder composition, which includes: adding water to the powder composition to mix to obtain a foamy food, and wrapping a medicine in the foamy food for taking.

[0057] As the powder composition used in the method of use, the above-mentioned powder composition can be mentioned. In addition, as the foamed food obtained by adding water to the powder composition and mixing it, the above-mentioned foamed food can be mentioned. As the medicament mixed into the foamed food, the above-mentioned medicament can be mentioned. By this method of use, when the medicament containing the active ingredient (i.e., the bitter ingredient) is orally ingested, the chance of the bitter ingredient directly contacting the tongue can be reduced, thereby reducing the bitterness felt by the ingestor and reducing the unpleasant feeling when taking it.

[0058] [Example] Hereinafter, the present invention will be described in detail with reference to Examples and the like of the present invention, but the present invention is not limited thereto.

[0059] [Confirmation test of masking effect] A foamy food was prepared from the powder composition of one example of the present invention, and the bitterness masking effect was confirmed.

[0060] <Preparation of Powder Composition> First, in each example and each comparative example, the raw materials described in the table were powdered and mixed to prepare powder compositions having the compositions shown in Tables 1 to 3.

[0061] <Preparation of Foamy Food> After that, follow the steps below to prepare the foamy food. 1. Preparation method of foamy food (※1 in each table) (1) Water (15° C.) was added to the powder composition to achieve the weight ratio described in the table. (2) Use a plastic spoon to stir for 30 times at a speed of 2 turns / second.

[0062] <Determination of specific gravity of foamy foods> The specific gravity of the obtained foamed food was calculated by the following method. 2 Specific gravity calculation method (※2 in each table) Put the foamy food into a 30cc container until it is scraped flat, and then measure the weight for calculation.

[0063] <Masking Evaluation> The bittering agent was mixed into the obtained foamed food to prepare a foamed food containing a bittering agent, and then the food was taken and evaluated (*3 in each table). The evaluation was performed by 6 professional panelists. The specific method is as follows.

[0064] 3 Masking evaluation method 3-1 Masking Object As a masking target, a bittering agent prepared as follows from a plant extract of the family Quassiae (Quassia extract) ("DC Bitter #20023", manufactured by Takata Flavors Co., Ltd.) of bitter components was used. 10% DC Bitard #20023, 45% corn starch and 45% lactose were mixed and extruded to prepare a granular bittering agent.

[0065] 3-2 Evaluation Method (1) 0.5 g of bittering agent was added to 6.8 g of foamy food prepared in advance. (2) A foamy food containing a bittering agent was prepared by stirring the mixture 10 times at a speed of 2 turns / second using a plastic spoon. (3) Take 1 teaspoon of a foamy food containing a bittering agent. (4) Evaluation was performed at three time points: A: immediately after ingestion (the taste first felt when the food is in the mouth); B: during chewing (the taste between A and C); and C: after swallowing (the taste that remains after swallowing).

[0066] 3-3 Evaluation Criteria, etc. · 0.5 g of the bittering agent was held in the mouth according to the general method of powdered medicine. The maximum bitterness when washed down with water was set as the upper limit (5 points) and no bitterness was felt at all as the lower limit (0 points). · Relative evaluation was performed on a 6-point scale ranging from 5 points (most bitter) to 0 points (no bitterness at all). · Evaluations from A to C are the averages of the six professional judges. The final evaluation was determined based on the average value of A to C as follows. ◎: 0 points or more and 1.5 points or less ○: More than 1.5 points and less than 2 points ×: More than 2 points and less than 5 points

[0067] <Example 1 to Example 4, Comparative Example 1 to Comparative Example 4> Table 1 below shows the compositions of the powder compositions of Examples 1 to 4 and Comparative Examples 1 to 4, the specific gravity of the foamed food, the masking evaluation results, and the like.

[0068] [Table 1]

[0069] The evaluation results showed that each example showed an excellent masking effect. Among them, the powder compositions of Examples 1 and 2 were able to prepare firm (strong) foamed foods. In addition, Example 2 showed a very good masking effect immediately after taking, during chewing, and after swallowing. In addition, according to the results of Examples 2, 3, and 4, it was confirmed that the masking effect tended to increase as the specific gravity of the foamed food decreased. On the other hand, in Comparative Examples 1 to 4, foamed foods could not be prepared, and sufficient masking effects could not be obtained.

[0070] The above results confirmed that a powder composition containing sugars, an acid component, a carbonic acid component, and a foam stabilizer can prepare a foamed food and mask the bitterness. It was also confirmed that the bitterness can be effectively masked continuously from immediately after taking the food to after swallowing if a masking component is used in combination.

[0071] <Example 5 to Example 24> The following Tables 2 and 3 show the compositions of the powder compositions of Examples 5 to 24, the specific gravity of the foamed food, the masking evaluation results, and the like.

[0072] [Table 2]

[0073] [Table 3]

[0074] As shown in Tables 2 and 3, all examples showed excellent masking effects.

[0075] [Confirmation test of masking effect of different forms] The masking effect of bitterness caused by the difference in food form was evaluated. Specifically, the masking effect was compared between the foamed food prepared from the powder composition of Example 1 and Example 2 and a known supplementary food for medication.

[0076] The specific method is as follows: The bittering agent used in Example 1 above was used as the bittering agent.

[0077] <Preparation of foamy food and foamy food containing bittering agent> Regarding Examples 1 and 2, a foamed food and a foamed food containing a bittering agent (*1 in Table 4) were prepared in the same manner as in Examples 1 and 2 in Table 1.

[0078] <Preparation of medicated supplementary foods and medicated supplementary foods containing bittering agents> (*2 in Table 4) Regarding Reference Example 1, 0.5 g of a bittering agent was dissolved in 1.5 cc of water by stirring and mixing, thereby preparing a liquid bittering agent-containing supplementary food. In Reference Example 2, 0.5 g of a bittering agent was coated in 25 g of "Okusuri Drink Metane (registered trademark) Strawberry Flavor (trade name)" (manufactured by Ryukakusan Co., Ltd.) to prepare a bittering agent-containing medication supplement in a jelly state. In Reference Example 3, 0.5 g of a bittering agent was coated in 18 g of "Okusuri Drink Metane (registered trademark) Chocolate Flavor (trade name)" (manufactured by Ryukakusan Co., Ltd.) to prepare a bittering agent-containing medication supplement in a jelly state.

[0079] <Masking Evaluation> The bittering agent was mixed into the obtained foamed food or supplementary food to prepare a bittering agent-containing food, and then taken and evaluated (*3 in Table 4). The evaluation was performed by 6 professional panelists. The specific method is as follows.

[0080] 0.5 g of the bittering agent was placed in the mouth according to the general method of a powdered medicine. The maximum bitterness when washed down with water was set as the upper limit (5 points) and no bitterness was felt at all as the lower limit (0 points). · Relative evaluation was performed on a 6-point scale ranging from 5 points (most bitter) to 0 points (no bitterness at all). Evaluation was performed at three time points: A: immediately after taking the food (the taste you first feel when holding the food in your mouth); B: during chewing (the taste between A and C); and C: after swallowing (the taste that remains after swallowing). · Evaluations from A to C are the averages of the six professional judges. The final evaluation was determined based on the average value of A to C as follows. ◎: 0 points or more and 1.5 points or less ○: More than 1.5 points and less than 2 points ×: More than 2 points and less than 5 points The results are shown in Table 4.

[0081] [Table 4]

[0082] The evaluation results showed that although Reference Examples 2 and 3 were slightly masked compared to Reference Example 1, the bitterness was hardly suppressed because bitterness was felt. On the other hand, Example 1 and Example 2 were confirmed to have a masking effect far exceeding Reference Examples 2 and 3. In particular, there was an overwhelming difference immediately after taking the medicine, and Example 1 and Example 2 hardly felt bitterness.

[0083] [Dissolution test] The dissolution of the medicaments was confirmed by mixing the medicaments into a foamed food of an example of the present invention. Specifically, four kinds of medicaments listed in Table 5 below were respectively included in the foamed food, and a dissolution test was carried out according to the method of the Japanese Pharmacopoeia. Among them, the foamed food was a foamed food prepared from the powder composition of Example 2 in the above-mentioned masking effect confirmation test. This dissolution test was carried out to determine whether an oral preparation conforms to the dissolution test standard (dissolution test specification).

[0084] The forms of the four kinds of medicaments shown in Table 5 are as follows. Paracetamol: fine granules Prednisolone: tablets Furosemide: fine granules Metronidazole: tablets

[0085] In addition, the control was to carry out the dissolution test with the medicament alone without being included in the foamed food. In addition, the dissolution standards for each medicament are shown in Table 5 together. The results of the dissolution test are shown in Figure 3 to Figure 6 .

[0086] [Table 5] Pharmaceutical (original drug) Dissolution Standards Figure 3 Acetaminophen 30 minutes 80% or more Figure 4 Prednisolone 20 minutes 70% or more Figure 5 Furosemide 15 minutes 85% or more Figure 6 Metronidazole 90 minutes 75% or more

[0087] As Figure 3 to Figure 6 shown, the foamed food of Example 2 containing the medicament meets the dissolution standards for all 4 kinds of medicaments tested. That is to say, the foamed food of the powder composition of the present invention does not affect the dissolution of the medicament.

[0088] [Post-ingestion questionnaire survey] <Example 25> After preparing the powder composition of Example 2, it was filled into an aluminum bag and sealed. Further, a container 100 Figure 2 and a resin spoon were prepared, and then they were sealed together in a packaging body to prepare a combined food (Example 25) for masking the bitterness of the medicament.

[0089] Example 25 and the following bitter agents were provided to 30 boys and girls aged 1 to 9 years. Foamed foods and foamed foods containing bitter agents were prepared in the same manner as in Example 2 of Table 1 and were fed to them, and a questionnaire survey was conducted. In addition, 30 boys and girls aged 1 to 9 years were each prepared with 1 guardian, and were fed by 30 boys and girls aged 1 to 9 years. Next, " Bitter: 4% DC Bitter #20023 and 96% corn starch were mixed and extruded to prepare a granular bitter.

[0090] Regarding Example 25, after explaining the following method, Questionnaire 1 was implemented to guardians. ·Powder composition, container, spoon already filled. ·You only need to prepare water at home. Contains 6 servings in total. ·The tray and spoon can be reused after cleaning. · Divide all into small portions 6 times and store for up to 24 months. Will not impair the effect of the medicine. · Even without a measuring spoon, the recessed lines on the tray can measure water.

[0091] <Questionnaire 1> "If there is a food supplement for taking medicine like Example 25, how much would you like to buy it?" ·I really want to buy Slightly want to buy Neither (don’t know) Not willing to buy Don't want to buy

[0092] For Example 25, a foamed food and a foamed food containing a bittering agent were prepared and ingested, and Questionnaires 2 and 3 were administered to males and females aged 1 to 9 years old, and Questionnaires 4 and 5 were administered to guardians. For Reference Example 3, a frozen medication supplement containing a bittering agent was prepared and ingested, and the same questionnaire was administered. <Questionnaire 2> “Does the medicine (bitter) have a bitter or offensive taste?” No medicinal smell at all. Almost no medicinal smell. Neither Slightly medicinal smell. ·It has a strong medicinal smell.

[0093] <Questionnaire 3> "How easy is it to take the medicine (bitters)?" Easy to take Slightly easier to take Slightly difficult to take Difficult to take

[0094] <Questionnaire 4> "How is the child?" ·I took it without any aversion. ·Although I felt a little disgusted, I took it. Neither Dislike, not taking much. · Dislike, almost no use.

[0095] <Questionnaire 5> "How easy is it to get him to take the medicine (bitters)?" Easy to take Slightly easier to take Slightly difficult to take Difficult to take

[0096] Finally, Questionnaire 6 was administered to the guardians. <Questionnaire 6> "Which one do you want to buy, Example 25 or Reference Example 3?" Example 25 ·Tendency Example 25 · Reference Example 3 Reference Example 3

[0097] The results of the questionnaire survey are shown in Table 6. Figure 7 to Figure 12 .

[0098] [Table 6]

[0099] The results of Questionnaires 2 to 5 show that Example 25 has a masking effect on the bittering agent, and since the masking effect is exerted, the bittering agent is easily ingested.

[0100] In addition, the results of the questionnaire survey showed that consumers desire medication supplementary foods with a masking effect in addition to existing jelly-like medication supplementary foods, and the present invention achieves a masking effect that exceeds that of existing medication supplementary foods.

[0101] The embodiments disclosed this time should be considered as illustrative in all aspects and not restrictive. The scope of the present invention is indicated by the claims rather than the above description, and is intended to include all modifications within the meaning and scope equivalent to the claims. [Explanation of symbols]

[0102] 10: Foamy foods containing medicines 11: Foamy Foods 12: Bubbles 13: Pharmacy 100: Container 110: Ontology Department 111: Bump 111a: Top surface 112: 2nd floor concave part 113: First recess 114: Second recess 115: Tank 120: Inabe 121: 3rd recess 130: Kong line

Claims

1. A powder composition, wherein: The powder composition is a powder composition for preparing a foamed food by mixing with water, and the powder composition contains the following components (A) to (D): (A) Sugar, (B) Acid component, (C) Carbonic acid component, (D) Foam stabilizer.

2. The powder composition according to claim 1, wherein The powder composition further contains the following component (E): (E) Masking component.

3. The powder composition according to claim 1, wherein The foamed food has a specific gravity of 0.83 g / cc or less.

4. The powder composition according to any one of claims 1 to 3, wherein The foam food is a foam food used for wrapping medicine for taking.

5. A combination food for masking the bitter taste of a medicament, wherein: The combination food has: The powder composition according to any one of claims 1 to 4, and (X) A container having two layers of recessed portions in the shape of an inverted mirror cake.

6. A method for masking the bitter taste of a medicament, wherein: The method comprises: adding water to a powder composition containing sugar, an acid component, a carbonic acid component, and a foam stabilizer to mix the mixture so as to prepare a foamy food, and then mixing the drug into the obtained foamy food.

7. Use of a powder composition, wherein: The use is to add water to the powder composition to mix it to make a foamy food, and then wrap the medicine in the foamy food for taking. The powder composition contains the following components (A) to (D): (A) Sugar, (B) Acid component, (C) Carbonic acid component, (D) Foam stabilizer.

8. A method of using a powder composition, wherein: The method comprises: adding water to the powder composition to obtain a foam food, and wrapping the medicine in the foam food for administration. The powder composition contains the following ingredients (A) to (D): (A) Sugar, (B) Acid component, (C) Carbonic acid component, (D) Foam stabilizer.

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