Pulse ablation control method, pulse ablation device and storage medium
By acquiring and analyzing the characterization parameters of the target biological tissues and adjusting the pulse signal parameters in the pulse ablation technology in real time, the problems of failure to meet the ablation effect and damage to surrounding tissues in the existing technology are solved, and a more efficient and safe pulse ablation effect is achieved.
Patent Information
- Application Number
- CN202311383678.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2023-10-23
- Publication Date
- 2025-04-25
AI Technical Summary
The existing pulse ablation technology cannot adjust the pulse parameters according to the ablation situation, resulting in the ablation effect not meeting the standard or damaging surrounding normal tissue cells.
By obtaining the characterization parameters of the target biological tissue, determining its ablation state, and adjusting the parameters of the pulse signal according to the ablation state to ensure that the ablation effect meets the standards and avoid damaging the surrounding tissue.
Real-time adjustment of pulse parameters according to the ablation state is achieved, which improves the ablation effect and avoids adverse consequences caused by excessive or low pulse energy.
Smart Images
Figure CN119867904A_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the technical field of pulse ablation, and in particular to a pulse ablation control method, a pulse ablation device and a storage medium. Background Art
[0002] Pulse ablation is a tissue ablation technology that uses extremely short but strong electric field pulses to instantly increase the permeability of cell membranes, creating nanopores on the cell membrane. Pulse ablation causes cell death by disturbing cell homeostasis.
[0003] Current pulse ablation technology usually determines the pulse parameters based on the characteristics of biological tissues before pulse ablation. During the pulse ablation process, the pulse parameters cannot be adjusted according to the ablation situation, which can easily lead to substandard ablation effects due to too low pulse energy, and can also easily cause damage to surrounding normal tissue cells when the pulse energy is too high. Summary of the invention
[0004] The purpose of the present application is to provide a pulse ablation control method, a pulse ablation device and a storage medium to address the deficiencies in the prior art, so as to solve the problems existing in the prior art.
[0005] To achieve the above purpose, the technical solution adopted in the embodiment of the present application is as follows:
[0006] In a first aspect, an embodiment of the present application provides a pulse ablation control method, comprising:
[0007] During the ablation process of the target biological tissue, obtaining a characterization parameter of the target biological tissue;
[0008] determining the ablation state of the target biological tissue according to the characterization parameter;
[0009] If the ablation state is an uncompleted ablation state, the parameters of the pulse signal for ablating the target biological tissue are adjusted to continue ablating the target biological tissue based on the pulse signal with the adjusted parameters.
[0010] In one embodiment, during the ablation process of the target biological tissue, obtaining the characterization parameters of the target biological tissue includes:
[0011] During the ablation process of the target biological tissue, acquiring the characterization parameters of the target biological tissue in real time; or,
[0012] During the ablation process of the target biological tissue, characterization parameters of the target biological tissue are acquired at a preset test time.
[0013] In one embodiment, the characterization parameters include: at least one type of characteristic parameter;
[0014] Determining the ablation state of the target biological tissue according to the characterization parameter includes:
[0015] Determining whether the at least one type of characteristic parameter satisfies the corresponding at least one type of preset parameter condition;
[0016] If there is a characteristic parameter of a target type that satisfies the corresponding preset parameter condition among the at least one type of characteristic parameters, determining that the ablation state of the target biological tissue is a completed ablation state;
[0017] If the at least one type of characteristic parameters does not satisfy the corresponding preset parameter conditions, the ablation state of the target biological tissue is determined to be an uncompleted ablation state.
[0018] In one embodiment, if the at least one type of characteristic parameters includes: a first type of characteristic parameters;
[0019] The respectively determining whether the at least one type of characteristic parameter satisfies the corresponding at least one type of preset parameter condition includes:
[0020] respectively comparing the characteristic parameters of the first type with corresponding preset parameter thresholds of the first type;
[0021] If the characteristic parameter of the first type is greater than the preset parameter threshold of the first type, determining that the characteristic parameter of the first type meets the preset parameter condition of the first type;
[0022] If the characteristic parameter of the first type is less than or equal to the preset parameter threshold of the first type, it is determined that the characteristic parameter of the first type does not meet the preset parameter condition of the first type.
[0023] In one embodiment, the first type of characteristic parameters includes: at least one of a current parameter and a voltage parameter;
[0024] Wherein, the preset parameter threshold of the current parameter is the preset current threshold of the target biological tissue;
[0025] The preset parameter threshold of the voltage parameter is a preset voltage threshold of the target biological tissue.
[0026] In one embodiment, if the at least one type of characteristic parameters includes: a second type of characteristic parameters;
[0027] The respectively determining whether the at least one type of characteristic parameter satisfies the corresponding at least one type of preset parameter condition includes:
[0028] respectively comparing the characteristic parameters of the second type with corresponding preset parameter thresholds of the second type;
[0029] If the characteristic parameter of the second type is less than the preset parameter threshold of the second type, determining that the characteristic parameter of the second type meets the preset parameter condition of the second type;
[0030] If the characteristic parameter of the second type is greater than or equal to the preset parameter threshold of the second type, it is determined that the characteristic parameter of the second type does not meet the preset parameter condition of the second type.
[0031] In one embodiment, the characteristic parameters of the second type include: impedance parameters;
[0032] The preset parameter threshold of the impedance parameter is a preset impedance threshold of the target biological tissue.
[0033] In one embodiment, before adjusting the parameters of the pulse signal for ablating the target biological tissue, the method further comprises: acquiring a temperature parameter of the target biological tissue;
[0034] If the ablation state is an uncompleted ablation state, adjusting the parameters of the pulse signal for ablating the target biological tissue includes:
[0035] When the temperature parameter is less than a preset temperature threshold of the target biological tissue, increasing the number of high-energy pulses in the pulse signal, and / or reducing the number of low-energy pulses in the pulse signal;
[0036] When the temperature parameter is greater than or equal to the preset temperature threshold, the number of high-energy pulses in the pulse signal is reduced, and / or the number of low-energy pulses in the pulse signal is increased.
[0037] In a second aspect, an embodiment of the present application provides a pulse ablation device, the pulse ablation device comprising: a measuring unit, a control unit, a pulse generating unit, and an ablation electrode;
[0038] The control unit is connected to the control end of the pulse generating unit to control the pulse generating unit to output a pulse signal; the output end of the pulse generating unit is connected to the ablation electrode to enable the ablation electrode to ablate the target biological tissue based on the pulse signal;
[0039] The measuring unit is used to measure the characteristic parameters of the target biological tissue; the measuring unit is connected to the control unit, and the control unit is used to execute the pulse ablation control method described in the above embodiment.
[0040] In a third aspect, an embodiment of the present application provides a storage medium having a computer program stored thereon. When the computer program is read and executed, the pulse ablation control method as described in the above embodiment is implemented.
[0041] Optionally, the embodiment of the present application further provides a pulse ablation control device, comprising:
[0042] An acquisition module, used for acquiring the characterization parameters of the target biological tissue during the ablation process of the target biological tissue;
[0043] A determination module, configured to determine the ablation state of the target biological tissue according to the characterization parameter;
[0044] The adjustment module is used to adjust the parameters of the pulse signal for ablating the target biological tissue if the ablation state is an uncompleted ablation state, so as to continue ablating the target biological tissue based on the pulse signal after the parameter adjustment.
[0045] The beneficial effects of the present application are as follows: the present application provides a pulse ablation control method, including obtaining characterization parameters of a target biological tissue during the ablation process of the target biological tissue; determining the ablation state of the target biological tissue based on the characterization parameters; if the ablation state is an incomplete ablation state, adjusting the parameters of a pulse signal for ablating the target biological tissue, so as to continue ablating the target biological tissue based on the pulse signal after the parameter adjustment.
[0046] Among them, during the ablation process of the target biological tissue, the ablation state of the target biological tissue is determined. When the ablation state of the target biological tissue is an incomplete ablation state, the parameters of the pulse signal can be adjusted in time, specifically: when the energy of the pulse signal is too low, its energy is increased to make the ablation effect of the target biological tissue meet the standard; when the energy of the pulse signal is too high, its energy is lowered to avoid damaging the surrounding normal tissue cells. BRIEF DESCRIPTION OF THE DRAWINGS
[0047] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.
[0048] Figure 1 A schematic diagram of the structure of a pulse ablation device provided in one embodiment of the present application;
[0049] Figure 2 One of the flow charts of the pulse ablation control method provided in one embodiment of the present application;
[0050] FIG3( a) is a schematic diagram of an initial pulse signal provided in an embodiment of the present application;
[0051] FIG3( b ) is a schematic diagram of an energy-enhanced pulse signal provided in an embodiment of the present application;
[0052] Figure 4 A second flowchart of a pulse ablation control method provided in an embodiment of the present application;
[0053] Figure 5 The third flowchart of the pulse ablation control method provided in one embodiment of the present application;
[0054] Figure 6 A fourth flowchart of a pulse ablation control method provided in an embodiment of the present application;
[0055] Figure 7 A fifth flowchart of a pulse ablation control method provided in an embodiment of the present application;
[0056] Figure 8 A schematic diagram of the structure of a pulse ablation control device provided in one embodiment of the present application;
[0057] Fig. 9 A schematic diagram of the structure of a control unit provided in one embodiment of the present application. DETAILED DESCRIPTION
[0058] In order to make the purpose, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments.
[0059] Therefore, the following detailed description of the embodiments of the present application provided in the accompanying drawings is not intended to limit the scope of the present application for which protection is sought, but merely represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present application.
[0060] In addition, the terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequential order. It should be understood that the data used in this way can be interchangeable where appropriate, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein. In addition, the terms "including" and "having" and any of their variations are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device comprising a series of steps or units is not necessarily limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.
[0061] It should be noted that, in the absence of conflict, the features in the embodiments of the present application may be combined with each other.
[0062] First, a pulse ablation device for executing the pulse ablation control method is described. Figure 1 A schematic diagram of the structure of a pulse ablation device provided in one embodiment of the present application is shown in FIG. Figure 1 As shown, the pulse ablation device includes a measuring unit 1 , a control unit 2 , a pulse generating unit 3 , and an ablation electrode 4 .
[0063] Among them, the measuring unit is used to measure the characterization parameters of the target biological tissue, the measuring unit is connected to the control unit, and the measured characterization parameters of the target biological tissue can be sent to the control unit; the control unit is used to execute the pulse ablation control method, the control unit is connected to the control end of the pulse generating unit to control the pulse generating unit to output the pulse signal, and the control unit can make the pulse generating unit adjust the parameters of its output pulse signal; the ablation electrode is in contact with the target biological tissue, and the output end of the pulse generating unit is connected to the ablation electrode, so that the ablation electrode ablates the target biological tissue based on the pulse signal.
[0064] On this basis, the pulse ablation control method provided in the present application is specifically illustrated below through multiple examples in combination with the accompanying drawings. The pulse ablation control method can be generated by any control device integrated with a preset pulse ablation control algorithm. The control device can be, for example, a control unit in a pulse ablation device.
[0065] Figure 2 This is one of the flow charts of the pulse ablation control method provided in one embodiment of the present application.
[0066] like Figure 2 As shown, the method includes:
[0067] S101. During the ablation process of the target biological tissue, obtaining characterization parameters of the target biological tissue.
[0068] During the process of ablating the target biological tissue by the pulse ablation device, characterization parameters of the target biological tissue are acquired, wherein the characterization parameters are parameters that can be used to characterize the ablation state of the target biological tissue.
[0069] S102: Determine the ablation state of the target biological tissue according to the characterization parameters.
[0070] After the characterization parameters are obtained, the ablation state of the target biological tissue can be determined according to the characterization parameters. The ablation state is divided into an unfinished ablation state and a completed ablation state.
[0071] S103: If the ablation state is an incomplete ablation state, adjust the parameters of the pulse signal for ablating the target biological tissue, so as to continue ablating the target biological tissue based on the pulse signal after the parameter adjustment.
[0072] If the ablation state is an incomplete ablation state, adjust the parameters of the pulse signal for ablation of the target biological tissue, specifically: when the energy of the pulse signal is too low, if the temperature of the target biological tissue does not exceed the preset temperature threshold, the energy of the pulse signal can be increased to continue ablation of the target biological tissue based on the pulse signal with the increased energy, so that the target biological tissue can be ablated; when the energy of the pulse signal is too high, there is a risk that the temperature of the target biological tissue exceeds the preset temperature threshold due to the excessive energy, thereby damaging the surrounding normal tissue cells. At this time, the energy of the pulse signal needs to be lowered to avoid damage to the surrounding normal tissue cells due to excessively high pulse energy.
[0073] In summary, by adopting the pulse ablation control method provided in this embodiment, the ablation state of the target biological tissue can be determined during the ablation process of the target biological tissue. When the ablation state of the target biological tissue is an incomplete ablation state, the parameters of the pulse signal can be adjusted in time, so that when the energy of the pulse signal is too low, the energy of the pulse signal is increased so that the ablation effect of the target biological tissue under the pulse signal with the increased energy is met. When the energy of the pulse signal is too high, the energy of the pulse signal is lowered to avoid damage to the surrounding normal tissue cells.
[0074] In one embodiment, the adjustment of the parameters of the pulse signal for ablation of the target biological tissue includes: when the energy of the pulse signal is too low, increasing the number of high-energy pulses in the pulse signal, and / or reducing the number of low-energy pulses in the pulse signal; when the energy of the pulse signal is too high, reducing the number of high-energy pulses in the pulse signal, and / or increasing the number of low-energy pulses in the pulse signal.
[0075] In the following, in conjunction with FIG. 3( a ) and FIG. 3( b ), the parameter adjustment of the pulse signal is described by taking the case where the energy of the pulse signal is too low as an example.
[0076] Figure 3(a) is a schematic diagram of an initial pulse signal provided in an embodiment of the present application, and Figure 3(b) is a schematic diagram of an energy-enhanced pulse signal provided in an embodiment of the present application. As shown in Figures 3(a) and 3(b), when the pulse ablation device is started, the ablation electrode ablates the target biological tissue with the initial pulse signal shown in Figure 3(a), and the initial pulse signal is a preset pulse signal with a fixed total energy; after adjusting the parameters of the pulse signal for ablation of the target biological tissue, the ablation electrode ablates the target biological tissue with the energy-enhanced pulse signal shown in Figure 3(b).
[0077] The difference between the energy-enhanced pulse signal and the initial pulse signal is that: the energy-enhanced pulse signal has a large number of high-energy pulses and / or a small number of low-energy pulses, so the total energy of the energy-enhanced pulse signal is higher than that of the initial pulse signal. During the ablation of the target biological tissue, if the ablation electrode ablates the target biological tissue with the initial pulse signal, the ablation effect will not meet the standard; adjusting the pulse signal to the energy-enhanced pulse signal so that the ablation electrode ablates the target biological tissue with the energy-enhanced pulse signal can achieve the ablation effect of the target biological tissue.
[0078] When the energy of the pulse signal is too high, the principle of adjusting the parameters of the pulse signal is similar to the above-mentioned embodiment, that is, adjusting the initial pulse signal to an energy attenuation type pulse signal, in which the number of high-energy pulses is small and / or the number of low-energy pulses is large. Then, the total energy of the energy attenuation type pulse signal is lower than that of the initial pulse signal, which will not be repeated here.
[0079] It should be noted that, optionally, in addition to adjusting the sub-energy intensity in the pulse signal as shown in Figures 3(a) and 3(b), the total energy of the pulse signal can also be adjusted by adjusting the pulse width, pulse duty cycle, amplitude, total number of pulses, and pulse interval of the pulse signal.
[0080] In one embodiment, the characterization parameters of the target biological tissue are obtained during the ablation process of the target biological tissue as described in S101, and the characterization parameters of the target biological tissue can be obtained in real time during the ablation process of the target biological tissue. In this way, the ablation state of the target biological tissue can be determined in real time, so as to adjust the parameters of the pulse signal in time, thereby avoiding the ablation effect of the target biological tissue not meeting the standard due to untimely adjustment.
[0081] Alternatively, during the ablation process of the target biological tissue, the characterization parameters of the target biological tissue can be obtained at a preset test time, wherein the preset test time can be when a type of pulse output ends, for example, in FIG3(b), when the high-energy pulse output ends, or when the low-energy pulse output ends, the characterization parameters of the target biological tissue are obtained. In this way, the time spent on determining the ablation state of the target biological tissue can be saved, thereby improving the speed of pulse ablation.
[0082] In one embodiment, the characterization parameters include at least one type of characteristic parameters, and the ablation state of the target biological tissue can be determined according to the at least one type of characteristic parameters.
[0083] Figure 4 The second flow chart of the pulse ablation control method provided in one embodiment of the present application is as follows: Figure 4 As shown, when the characterization parameters include at least one type of characteristic parameters, determining the ablation state of the target biological tissue according to the characterization parameters in S102 includes:
[0084] S201. Determine whether at least one type of characteristic parameter satisfies a corresponding at least one type of preset parameter condition.
[0085] When the characterization parameters include at least one type of characteristic parameters, it is necessary to determine whether the at least one type of characteristic parameters satisfies at least one type of preset parameter conditions, wherein the at least one type of characteristic parameters corresponds to the at least one type of preset parameter conditions.
[0086] S202: If there is a characteristic parameter of a target type that satisfies a corresponding preset parameter condition among at least one type of characteristic parameters, determining that the ablation state of the target biological tissue is a completed ablation state.
[0087] If there is a target type characteristic parameter in the at least one type of characteristic parameter that satisfies its corresponding preset parameter condition, the ablation state of the target biological tissue is determined to be the completed ablation state. The target type characteristic parameter can be any one of the at least one type of characteristic parameter.
[0088] S203: If at least one type of characteristic parameter does not satisfy the corresponding preset parameter condition, determining that the ablation state of the target biological tissue is an uncompleted ablation state.
[0089] If at least one type of characteristic parameter does not satisfy its corresponding preset parameter condition, the ablation state of the target biological tissue is determined to be an uncompleted ablation state.
[0090] That is, if the characterization parameters include at least one type of characteristic parameters, when any one of the characteristic parameters satisfies its corresponding preset parameter conditions, the ablation state of the target biological tissue is determined to be a completed ablation state; when all types of characteristic parameters do not satisfy their corresponding preset parameter conditions, the ablation state of the target biological tissue can be determined to be an unfinished ablation state.
[0091] When the characterization parameters include at least one type of characteristic parameters, the pulse ablation control method provided in this embodiment can be used to determine the ablation state of the target biological tissue.
[0092] In one embodiment, the at least one type of characteristic parameter includes a first type of characteristic parameter, and the first type of characteristic parameter refers to a characteristic parameter whose value is proportional to the ablation state of the target biological tissue.
[0093] Figure 5 The third flow chart of the pulse ablation control method provided in one embodiment of the present application is as follows: Figure 5 As shown, when at least one type of characteristic parameter includes a first type of characteristic parameter, determining in S201 whether at least one type of characteristic parameter satisfies the corresponding at least one type of preset parameter condition includes:
[0094] S301 . Compare characteristic parameters of a first type with corresponding preset parameter thresholds of the first type respectively.
[0095] When the at least one type of characteristic parameter includes a first type of characteristic parameter, each first type of characteristic parameter is compared with its corresponding first type preset parameter threshold.
[0096] S302: If the characteristic parameter of the first type is greater than the preset parameter threshold of the first type, determine that the characteristic parameter of the first type meets the preset parameter condition of the first type.
[0097] The numerical value of the first type of characteristic parameter is proportional to the ablation state of the target biological tissue. If the first type of characteristic parameter is greater than the first type of preset parameter threshold, it is determined that the first type of characteristic parameter meets the first type of preset parameter condition.
[0098] S302: If the characteristic parameter of the first type is less than or equal to the preset parameter threshold of the first type, determine that the characteristic parameter of the first type does not meet the preset parameter condition of the first type.
[0099] When at least one type of characteristic parameters includes characteristic parameters of the first type, the ablation state of the target biological tissue is determined according to the characterization parameters, which can be: when there are multiple characteristic parameters of the first type, if any one of the characteristic parameters of the first type satisfies its corresponding preset parameter conditions, the ablation state of the target biological tissue is determined to be a completed ablation state; when all the characteristic parameters of the first type do not satisfy their corresponding preset parameter conditions, the ablation state of the target biological tissue is determined to be an uncompleted ablation state.
[0100] Specifically, the characteristic parameter of the first type may include at least one of a current parameter and a voltage parameter, wherein the preset parameter threshold of the current parameter is a preset current threshold of the target biological tissue; and the preset parameter threshold of the voltage parameter is a preset voltage threshold of the target biological tissue. Before executing the pulse ablation control method, the preset current threshold and the preset voltage threshold may be obtained by experiment using a measuring unit according to the cell type of the target biological tissue.
[0101] In the process of executing the pulse ablation control method, the measuring unit obtains at least one of the current parameter and the voltage parameter in real time or at a preset test time, and the control unit compares the current parameter with the preset current threshold, and the voltage parameter with the preset voltage threshold, respectively. Since the principle of pulse ablation is: by applying a pulse signal to the target biological tissue, the irreversible perforation of the cell membrane of the target biological tissue is achieved, thereby causing the death of the target biological tissue cells. When the cell membrane of the target biological tissue dies, the cytoplasm and the external tissue fluid can flow, and its current, voltage and other parameters will increase, and after the increase, they will tend to be stable within a certain period of time. At this time, it can be judged that the target biological tissue has been ablated. Therefore, in this embodiment, when any one of the current parameter and the voltage parameter of the target biological tissue is greater than its corresponding threshold value, it can be determined that a perforation is formed on the cell membrane of the target biological tissue, and the ablation state of the target biological tissue is determined to be a completed ablation state, and the pulse generating unit is controlled to stop outputting the pulse signal; when the current parameter and the voltage parameter of the target biological tissue are both less than their corresponding threshold values, the ablation state of the target biological tissue is determined to be an uncompleted ablation state, and the parameters of the pulse signal for ablation of the target biological tissue are adjusted to increase the total energy of the pulse signal after the parameter adjustment, so as to continue to ablate the target biological tissue based on the pulse signal after the parameter adjustment.
[0102] In another embodiment, the at least one type of characteristic parameter includes a second type of characteristic parameter, and the second type of characteristic parameter refers to a characteristic parameter whose value is inversely proportional to the ablation state of the target biological tissue.
[0103] Figure 6 A fourth flow chart of a pulse ablation control method provided in an embodiment of the present application is shown in FIG. Figure 6As shown, when at least one type of characteristic parameter includes a second type of characteristic parameter, determining in S201 whether the at least one type of characteristic parameter satisfies the corresponding at least one type of preset parameter condition includes:
[0104] S401 . Compare characteristic parameters of the second type with corresponding preset parameter thresholds of the second type respectively.
[0105] When the at least one type of characteristic parameter includes a second type of characteristic parameter, each second type of characteristic parameter is compared with its corresponding second type preset parameter threshold.
[0106] S402: If the characteristic parameter of the second type is less than the preset parameter threshold of the second type, determine that the characteristic parameter of the second type meets the preset parameter condition of the second type.
[0107] The numerical value of the second type of characteristic parameter is inversely proportional to the ablation state of the target biological tissue. If the second type of characteristic parameter is less than the second type preset parameter threshold, it is determined that the second type of characteristic parameter meets the second type preset parameter condition.
[0108] S403: If the characteristic parameter of the second type is greater than or equal to the preset parameter threshold of the second type, determine that the characteristic parameter of the second type does not meet the preset parameter condition of the second type.
[0109] When at least one type of characteristic parameters includes characteristic parameters of the second type, the ablation state of the target biological tissue is determined according to the characterization parameters, which can be: when there are multiple characteristic parameters of the second type, if any one of the characteristic parameters of the second type meets its corresponding preset parameter conditions, the ablation state of the target biological tissue is determined to be a completed ablation state; when all the characteristic parameters of the second type do not meet their corresponding preset parameter conditions, the ablation state of the target biological tissue is determined to be an uncompleted ablation state.
[0110] Specifically, the second type of characteristic parameter may include an impedance parameter, and the preset parameter threshold of the impedance parameter is a preset impedance threshold of the target biological tissue. Before executing the pulse ablation control method, the preset impedance threshold may be obtained by experiment using a measurement unit according to the cell type of the target biological tissue.
[0111] In the process of executing the pulse ablation control method, the impedance parameters obtained by the measuring unit in real time or at a preset test time are compared with the preset impedance threshold. Since pulse ablation can cause the cell membrane of the target biological tissue cells to perforate and die, the cytoplasm and the external tissue fluid can flow after the cell death, and the impedance will decrease. Therefore, in this embodiment, when the impedance parameter is less than the preset impedance threshold, the ablation state of the target biological tissue is determined to be a completed ablation state, and the pulse generating unit is controlled to stop outputting the pulse signal; when the impedance parameter is greater than or equal to the preset impedance threshold, the ablation state of the target biological tissue is determined to be an uncompleted ablation state, and the parameters of the pulse signal for ablation of the target biological tissue are adjusted to increase the total energy of the pulse signal after the parameter adjustment, so as to continue to ablate the target biological tissue based on the pulse signal after the parameter adjustment.
[0112] It should also be noted that in the specific implementation process, there is a situation where the temperature of the target biological tissue is greater than its preset temperature threshold due to the heat generated by the pulse signal, but the ablation state of the target biological tissue is not completed at this time. If the temperature of the target biological tissue exceeds the preset temperature threshold, it will cause thermal damage to the surrounding normal tissue cells. Therefore, in the pulse ablation control process, the temperature parameters of the target biological tissue also need to be considered. Figure 7 Provide explanation.
[0113] Figure 7 A fifth flow chart of a pulse ablation control method provided in an embodiment of the present application is shown in FIG. Figure 7 As shown, in any of the above embodiments, before adjusting the parameters of the pulse signal for ablating the target biological tissue, the pulse ablation control method of the present application may further include:
[0114] S501. Acquire temperature parameters of target biological tissue.
[0115] In order to prevent the temperature of the target biological tissue from being greater than its preset temperature threshold, thereby causing thermal damage to the surrounding normal tissue cells, before adjusting the parameters of the pulse signal, the temperature parameters of the target biological tissue can be obtained in real time or at a preset test time through a measuring unit.
[0116] Then, in the above embodiment, if the ablation state is an uncompleted ablation state, the parameters of the pulse signal for ablating the target biological tissue may be adjusted as follows:
[0117] S502: Compare the temperature parameter of the target biological tissue with a preset temperature threshold of the target biological tissue.
[0118] After the temperature parameter of the target biological tissue is obtained, the temperature parameter of the target biological tissue is compared with a preset temperature threshold of the target biological tissue. The preset temperature threshold can be obtained by the measuring unit through experiments according to the cell type of the target biological tissue before executing the pulse ablation control method.
[0119] S503: When the temperature parameter is less than a preset temperature threshold, increase the number of high-energy pulses in the pulse signal, and / or reduce the number of low-energy pulses in the pulse signal.
[0120] When the temperature parameter is less than the preset temperature threshold, it is considered that there is no risk of thermal damage to normal tissue cells around the target biological tissue. Therefore, the number of high-energy pulses in the pulse signal can be increased, and / or the number of low-energy pulses in the pulse signal can be reduced.
[0121] Alternatively, when the temperature parameter is less than a preset temperature threshold, the total energy of the pulse signal is not adjusted, that is, the energy intensity of the current pulse signal is maintained, and pulse ablation of the target biological tissue continues. This can also enable the target biological tissue to complete pulse ablation based on the energy intensity of the current pulse signal.
[0122] S504: When the temperature parameter is greater than or equal to a preset temperature threshold, reduce the number of high-energy pulses in the pulse signal, and / or increase the number of low-energy pulses in the pulse signal.
[0123] When the temperature parameter is greater than or equal to the preset temperature threshold, the normal tissue cells around the target biological tissue are at risk of being damaged by thermal effects. At this time, it is necessary to adjust and reduce the number of high-energy pulses in the pulse signal, and / or increase the number of low-energy pulses in the pulse signal, so that the total energy of the pulse signal after the parameter adjustment is reduced, so as to continue to ablate the target biological tissue based on the pulse signal after the parameter adjustment, and avoid damage to the normal cell tissue around the target biological tissue due to excessively high temperature.
[0124] The following is a corresponding explanation of the device, control unit and storage medium for executing the pulse ablation control method provided by any of the above embodiments of the present application. Its specific implementation process and the technical effects produced are the same as those of the corresponding method embodiments mentioned above. For the sake of brief description, the parts not mentioned in the following embodiments can refer to the corresponding contents in the method embodiments.
[0125] Figure 8 A schematic diagram of the structure of a pulse ablation control device provided in an embodiment of the present application is shown in FIG. Figure 8 As shown, optionally, an embodiment of the present application provides a pulse ablation control device, comprising:
[0126] The acquisition module 100 is used to acquire the characterization parameters of the target biological tissue during the ablation process of the target biological tissue.
[0127] The determination module 200 is used to determine the ablation state of the target biological tissue according to the characterization parameters.
[0128] The adjustment module 300 is used to adjust the parameters of the pulse signal for ablating the target biological tissue if the ablation state is an uncompleted ablation state, so as to continue ablating the target biological tissue based on the pulse signal after the parameter adjustment.
[0129] Optionally, the acquisition module 100 is used to acquire the characterization parameters of the target biological tissue in real time during the ablation process of the target biological tissue; or, to acquire the characterization parameters of the target biological tissue at a preset test time during the ablation process of the target biological tissue.
[0130] Optionally, the determination module 200 is used to respectively determine whether at least one type of characteristic parameter satisfies the corresponding preset parameter condition of at least one type; if there is a characteristic parameter of the target type that satisfies the corresponding preset parameter condition among the at least one type of characteristic parameters, the ablation state of the target biological tissue is determined to be a completed ablation state; if none of the at least one type of characteristic parameters satisfies the corresponding preset parameter condition, the ablation state of the target biological tissue is determined to be an uncompleted ablation state.
[0131] Optionally, at least one type of characteristic parameter includes a first type of characteristic parameter; a determination module 200 is used to respectively compare the characteristic parameter of the first type with a corresponding first type of preset parameter threshold; if the characteristic parameter of the first type is greater than the first type of preset parameter threshold, it is determined that the characteristic parameter of the first type meets the first type of preset parameter condition; if the characteristic parameter of the first type is less than or equal to the first type of preset parameter threshold, it is determined that the characteristic parameter of the first type does not meet the first type of preset parameter condition.
[0132] Optionally, the first type of characteristic parameters includes: at least one of a current parameter and a voltage parameter; wherein the preset parameter threshold of the current parameter is a preset current threshold of the target biological tissue; and the preset parameter threshold of the voltage parameter is a preset voltage threshold of the target biological tissue.
[0133] Optionally, at least one type of characteristic parameter includes a second type of characteristic parameter; a determination module 200 is used to respectively compare the characteristic parameter of the second type with a corresponding second type of preset parameter threshold; if the characteristic parameter of the second type is less than the second type of preset parameter threshold, it is determined that the characteristic parameter of the second type meets the second type of preset parameter condition; if the characteristic parameter of the second type is greater than or equal to the second type of preset parameter threshold, it is determined that the characteristic parameter of the second type does not meet the second type of preset parameter condition.
[0134] Optionally, the second type of characteristic parameters includes: an impedance parameter; a preset parameter threshold of the impedance parameter is a preset impedance threshold of the target biological tissue.
[0135] Optionally, the acquisition module 100 is used to acquire temperature parameters of the target biological tissue.
[0136] The determination module 200 is used to compare the temperature parameter of the target biological tissue with a preset temperature threshold of the target biological tissue.
[0137] The adjustment module 300 is used to increase the number of high-energy pulses in the pulse signal and / or reduce the number of low-energy pulses in the pulse signal when the temperature parameter is less than a preset temperature threshold; when the temperature parameter is greater than or equal to the preset temperature threshold, reduce the number of high-energy pulses in the pulse signal and / or increase the number of low-energy pulses in the pulse signal.
[0138] The above-mentioned device is used to execute the method provided by the aforementioned embodiment, and its implementation principle and technical effect are similar, which will not be repeated here.
[0139] The above modules may be one or more integrated circuits configured to implement the above methods, such as one or more application specific integrated circuits (ASICs), or one or more microprocessors, or one or more field programmable gate arrays (FPGAs). For another example, when a module is implemented in the form of a processing element scheduling program code, the processing element may be a general-purpose processor, such as a central processing unit (CPU) or other processor that can call program code. For another example, these modules may be integrated together and implemented in the form of a system-on-a-chip (SOC).
[0140] Fig. 9 A schematic diagram of the structure of a control unit provided in an embodiment of the present application is shown in FIG. Fig. 9 As shown, the control unit includes: a processor 10, a storage medium 20, and a bus 30. The processor and the storage medium communicate through the bus. The storage medium stores program instructions executable by the processor. When the processor executes the program instructions, the pulse ablation control method provided in the above method embodiment is implemented.
[0141] An embodiment of the present application further provides a storage medium having a computer program stored thereon. When the computer program is read and executed, the pulse ablation control method provided in the above method embodiment is implemented.
[0142] In the several embodiments provided in the present application, it should be understood that the disclosed devices and methods can be implemented in other ways. For example, the device embodiments described above are only schematic. For example, the division of the units is only a logical function division. There may be other division methods in actual implementation, such as multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be through some interfaces, indirect coupling or communication connection of devices or units, which can be electrical, mechanical or other forms.
[0143] The units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed on multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution of this embodiment.
[0144] In addition, each functional unit in each embodiment of the present application may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above-mentioned integrated unit may be implemented in the form of hardware or in the form of hardware plus software functional units.
[0145] The above-mentioned integrated unit implemented in the form of a software functional unit can be stored in a computer-readable storage medium. The above-mentioned software functional unit is stored in a storage medium, including a number of instructions for a computer device (which can be a personal computer, a server, or a network device, etc.) or a processor (English: processor) to perform some steps of the method described in each embodiment of the present application. The aforementioned storage medium includes: U disk, mobile hard disk, read-only memory (English: Read-Only Memory, abbreviated: ROM), random access memory (English: Random Access Memory, abbreviated: RAM), disk or optical disk and other media that can store program codes.
[0146] The above are only specific implementations of the present application, but the protection scope of the present application is not limited thereto. Any changes or substitutions that can be easily thought of by a person skilled in the art within the technical scope disclosed in the present application should be included in the protection scope of the present application. Therefore, the protection scope of the present application should be based on the protection scope of the claims.
Claims
1. A pulse ablation control method, characterized in that: include: During the ablation process of the target biological tissue, obtaining a characterization parameter of the target biological tissue; determining the ablation state of the target biological tissue according to the characterization parameter; If the ablation state is an uncompleted ablation state, the parameters of the pulse signal for ablating the target biological tissue are adjusted to continue ablating the target biological tissue based on the pulse signal with the adjusted parameters.
2. The method according to claim 1, characterized in that During the ablation process of the target biological tissue, obtaining the characterization parameters of the target biological tissue includes: During the ablation process of the target biological tissue, acquiring the characterization parameters of the target biological tissue in real time; or, During the ablation process of the target biological tissue, characterization parameters of the target biological tissue are acquired at a preset test time.
3. The method according to claim 1, characterized in that The characterization parameters include: at least one type of characteristic parameter; Determining the ablation state of the target biological tissue according to the characterization parameter includes: Determining whether the at least one type of characteristic parameter satisfies the corresponding at least one type of preset parameter condition; If there is a characteristic parameter of a target type that satisfies the corresponding preset parameter condition among the at least one type of characteristic parameters, determining that the ablation state of the target biological tissue is a completed ablation state; If the at least one type of characteristic parameters does not satisfy the corresponding preset parameter conditions, the ablation state of the target biological tissue is determined to be an uncompleted ablation state.
4. The method according to claim 3, characterized in that If the at least one type of characteristic parameters includes: a first type of characteristic parameters; The respectively determining whether the at least one type of characteristic parameter satisfies the corresponding at least one type of preset parameter condition includes: respectively comparing the characteristic parameters of the first type with corresponding preset parameter thresholds of the first type; If the characteristic parameter of the first type is greater than the preset parameter threshold of the first type, determining that the characteristic parameter of the first type meets the preset parameter condition of the first type; If the characteristic parameter of the first type is less than or equal to the preset parameter threshold of the first type, it is determined that the characteristic parameter of the first type does not meet the preset parameter condition of the first type.
5. The method according to claim 4, characterized in that The first type of characteristic parameters includes: at least one of a current parameter and a voltage parameter; Wherein, the preset parameter threshold of the current parameter is the preset current threshold of the target biological tissue; The preset parameter threshold of the voltage parameter is a preset voltage threshold of the target biological tissue.
6. The method according to claim 3, characterized in that: If the at least one type of characteristic parameters includes: a second type of characteristic parameters; The respectively determining whether the at least one type of characteristic parameter satisfies the corresponding at least one type of preset parameter condition includes: respectively comparing the characteristic parameters of the second type with corresponding preset parameter thresholds of the second type; If the characteristic parameter of the second type is less than the preset parameter threshold of the second type, determining that the characteristic parameter of the second type meets the preset parameter condition of the second type; If the characteristic parameter of the second type is greater than or equal to the preset parameter threshold of the second type, it is determined that the characteristic parameter of the second type does not meet the preset parameter condition of the second type.
7. The method according to claim 6, characterized in that The characteristic parameters of the second type include: impedance parameters; The preset parameter threshold of the impedance parameter is a preset impedance threshold of the target biological tissue.
8. The method according to any one of claims 1 to 7, characterized in that: Before adjusting the parameters of the pulse signal for ablating the target biological tissue, the method further includes: acquiring the temperature parameters of the target biological tissue; If the ablation state is an uncompleted ablation state, adjusting the parameters of the pulse signal for ablating the target biological tissue includes: comparing a temperature parameter of the target biological tissue with a preset temperature threshold of the target biological tissue; When the temperature parameter is less than the preset temperature threshold, increasing the number of high-energy pulses in the pulse signal, and / or reducing the number of low-energy pulses in the pulse signal; When the temperature parameter is greater than or equal to the preset temperature threshold, the number of high-energy pulses in the pulse signal is reduced, and / or the number of low-energy pulses in the pulse signal is increased.
9. A pulse ablation device, characterized in that: The pulse ablation device comprises: a measuring unit, a control unit, a pulse generating unit, and an ablation electrode; The control unit is connected to the control end of the pulse generating unit to control the pulse generating unit to output a pulse signal; the output end of the pulse generating unit is connected to the ablation electrode to enable the ablation electrode to ablate the target biological tissue based on the pulse signal; The measuring unit is used to measure the characterizing parameters of the target biological tissue; the measuring unit is connected to the control unit, and the control unit is used to execute the pulse ablation control method described in any one of claims 1-8.
10. A storage medium, characterized in that: The storage medium stores a computer program, and when the computer program is read and executed, the pulse ablation control method described in any one of claims 1 to 8 is implemented.