Anti-dandruff and oil-control shampoo preparation and preparation method thereof

Abstract

The invention provides an anti-dandruff and oil-control shampoo preparation which comprises hawthorn fruit extract, sodium lauroyl methyl aminopropionate, C14-C16 sodium olefin sulfonate, sodium methyl cocoyl taurate and the like, and the shampoo preparation is not added with common sulfate surfactants such as ammonium lauryl sulfate and sodium laureth sulfate. The anti-dandruff and oil-control shampoo disclosed by the invention has a relatively strong anti-dandruff and oil-control effect, also has a relatively strong inhibition effect on malassezia, can be used for effectively controlling skin oil and has a relatively strong moisturizing effect, and hair after being washed has a soft and fluffy feeling.

Description

Technical Field

[0001] The invention relates to the field of shampoos, in particular to an anti-dandruff and oil-control shampoo and a preparation method thereof. Background Art

[0002] Dandruff, also known as scalp pityriasis, has an incidence rate of up to 50% in the population. When scratching, you can see dandruff falling like snowflakes. Young people are prone to dandruff. People who often suffer from dandruff have dry, brittle, and falling hair, which makes the hair thin or bald, causing a lot of trouble to people's lives and affecting everyone's health and personal image.

[0003] Seborrheic dermatitis is the most common cause of dandruff. Malassezia, also known as Pityrosporum, is a fungus that normally lives on the surface of human skin. Its number increases significantly in patients with dandruff and seborrheic dermatitis. It is closely related to sebum, which provides nutrition for the flora colonizing the scalp. Malassezia digests triglycerides in sebum and releases oleic acid that can penetrate the stratum corneum, leading to excessive proliferation, incomplete keratinization and sebum secretion. Eradicating or controlling Malassezia in the scalp can effectively relieve itching and reduce the formation of scales. It is the most important and simplest method for treating dandruff and seborrheic dermatitis.

[0004] At present, there are two types of surfactants commonly used in daily shampoos on the market, one is the sulfate system, and the other is the amino acid system. Common sulfate systems include sodium lauryl sulfate, sodium laureth sulfate, etc. These ingredients have strong degreasing properties, but are highly irritating to the skin. Currently, well-known shampoo brands such as Yangyuanqing, Ziyuan, and Siyun on the market all contain sodium laureth sulfate. Commonly used preservatives generally contain methylisothiazolinone, methylchloroisothiazolinone, trichlorobutanol, etc. Although the above chemical preparations have certain antiseptic functions, they are less safe and have certain irritation to the scalp. Therefore, the Cosmetic Safety Technical Specifications have set limits on their maximum concentrations. Commonly used antidandruff agents include: zinc pyrithione (ZPT), piroctone olamine salt (OCT), climbazole, ketoconazole, salicylic acid, etc., and their effects are also to inhibit Malassezia, for example, the shampoo compositions provided in 201310177609.1 and 201710548938.0 all contain piroctone olamine salt. However, if the raw materials such as piroctone olamine salt are added in a higher proportion, it is easy to produce greater stimulation to the scalp, thereby causing inflammation, which is the direct cause of itchy head and dandruff. These factors limit the scope of use and effect of the above-mentioned antidandruff agents, and the proportion and dosage need to be strictly controlled during use, otherwise it will be counterproductive. In addition, hair conditioners commonly used in the field of shampoo include Chinese herbal extracts or plant extracts. Chinese herbal extracts contain a variety of natural active ingredients, have a variety of pharmacological effects, and have a wide range of target effects. However, adding too much Chinese herbal extracts does not necessarily bring ideal effects, because too much Chinese herbal ingredients are added, not only the smell is difficult for consumers to accept, but the irritation of Chinese herbal extracts is also not negligible. Long-term use by consumers is prone to cause new situations such as poor hair quality, itchy scalp, dry and easy hair breakage, etc. For example, 200910094201.1 provides a Chinese herbal shampoo, which is made of 0.25-8 weight parts of Platycladus orientalis leaves, 0.25-8 weight parts of Cnidium monnieri, 0.25-8 weight parts of Pishao, and 0.25-8 weight parts of Fragrant Tea, and then 68-99 weight parts of conventional shampoo base are added to make it. Therefore, the current market of toiletries prefers shampoos that are mild, low in irritation, can effectively control oil and solve dandruff, improve hair quality with long-term use, and make hair fluffy and natural after washing. In view of the problems existing in the prior art, the present invention provides a shampoo preparation containing an appropriate amount of Chinese herbal extract, which can produce a synergistic effect with other ingredients in the formula, has strong dandruff removal and oil control, can effectively inhibit Malassezia, and is safe and non-irritating for long-term use. Summary of the invention

[0005] In order to solve the problems existing in the prior art, a shampoo preparation with anti-dandruff and oil control and low irritation and a preparation method thereof are provided. The shampoo preparation provided by the present invention has a strong inhibitory effect on Malassezia, and has the effects of removing dandruff and relieving itching, controlling the secretion of oil, and repairing hair and scalp skin barrier damage. After shampooing, the hair is relatively fluffy, and the product also has a certain moisturizing effect. After shampooing, the hair can be obviously felt to be smoother than before shampooing.

[0006] In order to achieve the above-mentioned object of the invention, the present invention adopts the following technical solutions:

[0007] 1. A shampoo preparation for removing dandruff and controlling oil, which comprises the following components by weight percentage: Phase A: 20-50% of surfactant;

[0008] Phase B: hair conditioning agent 0.83-2.34%, anti-dandruff agent 0.02-0.06%;

[0009] Phase C: preservative 0.5-1.4%, essence 0.3-0.6%, thickener 0.263-0.315%, pH adjuster 0.13-0.18%, chelating agent 0.06-0.12%, the hair conditioning agent includes hawthorn fruit extract, and the balance is water. Preferably, the surfactant is selected from one or a mixture of at least two of sodium lauroyl methylaminopropionate, phenoxyethanol, ethylhexylglycerin, sodium C14-16 olefin sulfonate, cocamidopropyl betaine, sodium methyl cocoyl taurate, cocamidomethyl MEA, and sodium chloride.

[0010] Preferably, the hair conditioning agent includes one or a mixture of at least two of polyglyceryl-10 dipalmitate, palmitamidopropyltrimonium chloride, sodium isostearyl lactylate, polyquaternium-10, butylene glycol, and phenoxyethanol.

[0011] Preferably, the preservative is selected from at least one of phenoxyethanol, ethylhexylglycerin and dichlorobenzyl alcohol. Preferably, an anti-dandruff and oil-control shampoo preparation comprises the following components in weight percentage:

[0012] Phase A: 4.1-5.3% sodium lauroyl methylaminopropionate, 0.03-0.12% phenoxyethanol, 0.0025-0.01% ethylhexylglycerin, 3.8-5.0% sodium C14-C16 olefin sulfonate, 2.4-3.3% cocamidopropyl betaine, 0.5-1.2% sodium chloride, 1.36-2.05% sodium methyl cocoyl taurate, 1.4-2.4% cocamide methyl MEA, 0.08-0.31% glycerol, and the balance is water; the sodium C14-16 olefin sulfonate can produce a large amount of foam in the shampoo, clean the dirt and grease in the scalp and hair, make the hair clean, light and soft, and keep the hair healthy. Sodium C14-16 olefin sulfonate can also adjust the pH value and consistency of the shampoo, making the use effect of the shampoo more outstanding. It should be noted that although sodium C14-16 olefin sulfonate is an effective surfactant, excessive use of shampoo and other hair care products containing surfactants will damage the natural protective layer of the hair, causing the hair to become dry, frizzy, and easy to break. Therefore, when using it, you must pay attention to the appropriate amount. Adding a certain proportion of hawthorn fruit extract can neutralize its irritation, maintain its ability to remove grease and dandruff, and not affect the health of the skin surface.

[0013] Phase B: 0.42-0.73% polyglycerol-10 dipalmitate, 0.27-0.63% palmitamidopropyl trimethyl ammonium chloride, 0.05-0.13% sodium isostearyl lactylate, 0.19-0.34% polyquaternium-10, 0.02-0.06% antidandruff agent, 0.001-0.005% butylene glycol, 0.15-0.36% hawthorn fruit extract, and the balance is water; the hawthorn fruit extract has a significant inhibitory effect on Malassezia and has little effect on the scalp microecology. It also has anti-inflammatory and antioxidant effects, can effectively relieve itching, sensitivity and discomfort of the scalp; it can change the composition of secreted sebum, reduce the production of triglycerides and fatty acids in sebum, and effectively improve the softness and oiliness of the scalp.

[0014] Phase C: phenoxyethanol 0.46-0.65%, ethylhexylglycerin 0.04-0.08%, fragrance 0.3-0.6%, PEG-150 distearate 0.263-0.315%, pH adjuster 0.13-0.18%, dichlorobenzyl alcohol 0.05-0.13%, chelating agent 0.06-0.12%, and the balance is water.

[0015] Preferably, the shampoo preparation of the present invention comprises the following components in parts by weight:

[0016] Phase A: Sodium lauroyl methylaminopropionate 4.5%, phenoxyethanol 0.07%, ethylhexylglycerin 0.0075%, sodium C14-C16 olefin sulfonate 4.2%, cocamidopropyl betaine 2.8%, sodium chloride 0.7%, sodium methyl cocoyl taurate 1.68%, cocamidomethyl MEA 1.8%, glycerin 0.2%, the balance is water; Phase B: polyglyceryl-10 dipalmitate 0.54%, palmitamidopropyl trimethylammonium chloride 0.57%, sodium isostearyl lactylate 0.09%, polyquaternium-10 0.25%, anti-dandruff agent 0.05%, butylene glycol 0.004%, hawthorn fruit extract 0.28%, the balance is water;

[0017] Phase C: phenoxyethanol 0.54%, ethylhexylglycerin 0.06%, fragrance 0.4%, PEG-150 distearate 0.297%, pH adjuster 0.15%, dichlorobenzyl alcohol 0.1%, chelating agent 0.1%, and the balance is water.

[0018] Preferably, the anti-dandruff agent is selected from at least one of pyrithione zinc, piroctone olamine salt, and hexamidine di(hydroxyethylsulfonate) salt.

[0019] Preferably, the pH adjuster is selected from at least one of citric acid, sodium citrate and arginine.

[0020] Preferably, the chelating agent comprises at least one of disodium EDTA, citric acid, sodium citrate, sodium dihydrogen phosphate, disodium hydrogen phosphate, tetrasodium etidronic acid, hydroxyethylidene diphosphonic acid, HEPES buffer, salicylic acid, sodium salicylate and diethylenetriaminepentaacetic acid.

[0021] Preferably, the phase B also includes at least one of a root extract of Sophora flavescens, a root extract of Angelica sinensis, a leaf extract of Platycladus orientalis, and a bark extract of Salix alba.; The spiny gum is a high molecular weight polysaccharide mainly composed of polysaccharide galactomannan, and has good water retention and film-forming properties.

[0022] Preferably, the invention is characterized in that: the preparation process of the hawthorn fruit extract is to take 100 parts of hawthorn fruit, remove the core, crush into coarse particles, add 60% to 90% ethanol in an amount 8 to 12 times the weight ratio of the medicinal material, heat and reflux to extract 1 to 3 times, each time for 1 to 2 hours, filter, combine the filtrate, and retain the medicinal liquid; add 6 to 10 times the weight ratio of the medicinal material to the medicinal residue, heat and boil to extract 1 to 3 times, each time for 1 to 2 hours, filter, combine the filtrate, and retain the water liquid;

[0023] The preparation method of the anti-dandruff and oil-control shampoo provided by the present invention comprises the following steps:

[0024] 1) Weighing and adding materials: weigh the raw materials of each component in order according to the formula ratio, and add phase A into the ingredient pot; 2) Stirring and heating: Stirring and heating to 85°C, stirring and dispersing until the raw materials are evenly mixed, and continue to keep warm for 30 minutes;

[0025] 3) Discharging: Keep warm and then cool down. When the temperature drops to 45°C, add phase B and stir evenly. When the temperature drops to 40°C, add phase C and stir evenly. Filter and discharge;

[0026] 4) Standing: After discharging, the material is left to stand for 12 hours;

[0027] 5) Testing: Take samples for testing 12 hours after discharge;

[0028] 6) Filling and packaging: After the material has passed the inspection, it is filled after being sterilized;

[0029] 7) Inspection and storage: After the finished product is inspected and qualified, the raw materials are weighed according to the quality, mixed, left to stand, and filled. Preferably, the shampoo preparation provided by the present invention is used for preparing an anti-dandruff and oil-controlling shampoo preparation.

[0030] Compared with the prior art, the present invention has the following beneficial effects:

[0031] 1. The anti-dandruff and oil-control shampoo preparation provided by the present invention selects hawthorn fruit extract as a hair conditioner, which can effectively relieve itching and sensitive discomfort of the scalp, has a significant inhibitory effect on Malassezia, and has little effect on the scalp microecology.

[0032] 2. The anti-dandruff and oil-control shampoo preparation provided by the present invention combines hawthorn fruit extract, amino acid surfactant, and C14-C16 sodium olefin sulfonate with each other, and the components synergize to produce the effects of anti-dandruff and antipruritic, and can prevent the recurrence of dandruff and itching; it has a strong control effect on scalp oil, reduces the use of chemical anti-dandruff agents, and reduces irritation to the scalp.

[0033] 3. The anti-dandruff and oil-control shampoo preparation provided by the present invention does not add sulfate surfactants or silicone oil, and has a very obvious fluffy effect after shampooing and drying, and is suitable for oily hair and soft hair.

[0034] 4. The preparation process of the product of the present invention is simple, easy to produce, and conducive to the industrialization of the product. DETAILED DESCRIPTION

[0035] The present invention is further described below in conjunction with the examples and comparative examples, but the present invention is not limited in any way. Any changes or substitutions made based on the teachings of the present invention belong to the protection scope of the present invention. In the following specific embodiments, unless otherwise specified, all conventional methods are used; the raw materials, reagent materials, etc. used in the following specific embodiments, unless otherwise specified, are all commercially available products.

[0036] Embodiment 1:

[0037] A shampoo preparation with anti-dandruff and oil control properties, wherein the shampoo preparation comprises the following components in weight percentage:

[0038] Phase A: Sodium lauroyl methylaminopropionate 4.5%, phenoxyethanol 0.07%, ethylhexylglycerin 0.0075%, sodium C14-C16 olefin sulfonate 4.2%, cocamidopropyl betaine 2.8%, sodium chloride 0.7%, sodium methyl cocoyl taurate 1.68%, cocamide methyl MEA 1.8%, glycerin 0.2%, the balance is water;

[0039] Phase B: Polyglyceryl-10 Dipalmitate 0.54%, Palmitamidopropyl Trimethylammonium Chloride 0.57%, Sodium Isostearyl Lactylate 0.09%, Polyquaternium-10 0.25%, Piroctone Olamine Salt 0.05%, Butylene Glycol 0.004%, Hawthorn Fruit Extract 0.28%;

[0040] Phase C: Phenoxyethanol 0.54%, Ethylhexylglycerin 0.06%, Fragrance 0.4%, PEG-150 Distearate 0.297%, Citric Acid 0.15%, Dichlorobenzyl Alcohol 0.1%, Disodium EDTA 0.1%.

[0041] The preparation process of the shampoo preparation is as follows:

[0042] 1) Weighing and adding materials: Weigh each group of raw materials in order according to the formula and record them. Add phase A into the batching pot;

[0043] 2) Stirring and heating: Turn on the stirring and heating to 85°C, stir and disperse until the raw materials are evenly mixed, and continue to keep warm for 30 minutes;

[0044] 3) Cooling and discharging: Cooling after keeping warm, adding hair conditioner (B phase component) after the temperature drops to 45°C and stirring evenly, cooling to 40°C, adding preservative, chelating agent, pH adjuster, thickener, fragrance in turn and stirring evenly (C phase component), filtering and discharging;

[0045] 4) Standing: After the material is discharged, mark it and make production records, and let the material stand for 12 hours;

[0046] 5) Chemical analysis: 12 hours after discharge, take samples to test physical, chemical and microbiological indicators;

[0047] 6) Filling and packaging: After the material is inspected and qualified, the inner packaging material is sterilized and then filled and packaged to transform it into a finished product;

[0048] 7) Inspection and storage: The finished product is inspected and qualified, sealed, stored, and the raw materials are weighed according to quality, mixed, left to stand, and filled to obtain the preparation.

[0049] Embodiment 2:

[0050] A shampoo preparation with anti-dandruff and oil control properties, wherein the shampoo preparation comprises the following components in weight percentage:

[0051] Phase A: 4.1% sodium lauroyl methylaminopropionate, 0.12% phenoxyethanol, 0.01% ethylhexylglycerin, 3.8% sodium C14-C16 olefin sulfonate, 2.4% cocamidopropyl betaine, 0.5% sodium chloride, 1.36% sodium methyl cocoyl taurate, 1.4% cocamide methyl MEA, 0.08% glycerin, the balance is water;

[0052] Phase B: Polyglyceryl-10 Dipalmitate 0.42%, Palmitamidopropyl Trimethylammonium Chloride 0.63%, Sodium Isostearyl Lactylate 0.13%, Polyquaternium-10 0.19%, Piroctone Olamine Salt 0.02%, Butylene Glycol 0.001%, Hawthorn Fruit Extract 0.15%;

[0053] Phase C: Phenoxyethanol 0.65%, Ethylhexylglycerin 0.08%, Fragrance 0.6%, PEG-150 Distearate 0.315%, Citric Acid 0.18%, Dichlorobenzyl Alcohol 0.13%, Disodium EDTA 0.12%.

[0054] The preparation process of the shampoo preparation is the same as that of Example 1.

[0055] Embodiment 3:

[0056] A shampoo preparation with anti-dandruff and oil control properties, wherein the shampoo preparation comprises the following components in weight percentage:

[0057] Phase A: 5.3% sodium lauroyl methylaminopropionate, 0.03% phenoxyethanol, 0.0025% ethylhexylglycerin, 5.0% sodium C14-C16 olefin sulfonate, 3.3% cocamidopropyl betaine, 1.2% sodium chloride, 2.05% sodium methyl cocoyl taurate, 2.4% cocamide methyl MEA, 0.31% glycerin, the balance is water;

[0058] Phase B: Polyglyceryl-10 Dipalmitate 0.73%, Palmitamidopropyl Trimethylammonium Chloride 0.27%, Sodium Isostearyl Lactylate 0.05%, Polyquaternium-10 0.34%, Piroctone Olamine Salt 0.06%, Butylene Glycol 0.005%, Hawthorn Fruit Extract 0.36%;

[0059] Phase C: Phenoxyethanol 0.46%, Ethylhexylglycerin 0.04%, Fragrance 0.3%, PEG-150 Distearate 0.263%, Citric Acid 0.13%, Dichlorobenzyl Alcohol 0.05%, Disodium EDTA 0.06%.

[0060] The preparation process of the shampoo preparation is the same as that of Example 1.

[0061] Embodiment 4:

[0062] A shampoo preparation with anti-dandruff and oil control properties, wherein the shampoo preparation comprises the following components in weight percentage:

[0063] Phase A: Sodium lauroyl methylaminopropionate 4.5%, phenoxyethanol 0.07%, ethylhexylglycerin 0.0075%, sodium C14-C16 olefin sulfonate 4.2%, cocamidopropyl betaine 2.8%, sodium chloride 0.7%, sodium methyl cocoyl taurate 1.68%, cocamide methyl MEA 1.8%, glycerin 0.2%, the balance is water;

[0064] Phase B: Polyglyceryl-10 Dipalmitate 0.54%, Palmitamidopropyl Trimethylammonium Chloride 0.57%, Sodium Isostearyl Lactylate 0.09%, Polyquaternium-10 0.25%, Piroctone Olanthamine 0.05%, Butylene Glycol 0.004%, Crataegus Pinnatifida Fruit Extract 0.28%, Sophora Flavescens Root Extract 0.1%, Angelica Acutiloba Root Extract 0.1%, Thuja Spinosa Gum 0.1%, Platycladus Orientalis Leaf Extract 0.1%, Salix Alba Bark Extract 0.1%.

[0065] Phase C: Phenoxyethanol 0.54%, Ethylhexylglycerin 0.06%, Fragrance 0.4%, PEG-150 Distearate 0.297%, Citric Acid 0.15%, Dichlorobenzyl Alcohol 0.1%, Disodium EDTA 0.1%.

[0066] Comparative Example 1

[0067] The difference between Comparative Example 1 and Example 1 is that Comparative Example 1 does not contain hawthorn fruit extract;

[0068] Comparative Example 2

[0069] The difference between Comparative Example 2 and Example 1 is that the 0.28% of hawthorn fruit extract in Example 1 is replaced with 0.28% of thuja serrata leaf extract;

[0070] Comparative Example 3

[0071] The difference between Comparative Example 3 and Example 1 is that the 0.28% hawthorn fruit extract in Example 1 is replaced with 0.28% sophora flavescens root extract;

[0072] Comparative Example 4

[0073] The difference between Comparative Example 4 and Example 1 is that, in addition to adding 0.28% of hawthorn fruit extract, Comparative Example 4 also adds 0.1% of Pleurotus eryngii leaf extract, 0.1% of Sophora flavescens root extract, and 0.1% of Angelica sinensis root extract;

[0074] Comparative Example 5

[0075] The difference between Comparative Example 5 and Example 1 is that Comparative Example 5 does not contain sodium lauroylmethylaminopropionate;

[0076] Comparative Example 6

[0077] The only difference between Comparative Example 6 and Example 1 is that Comparative Example 6 does not contain sodium C14-C16 olefin sulfonate;

[0078] Comparative Example 7

[0079] The difference between Comparative Example 7 and Example 1 is that Comparative Example 7 does not contain sodium methyl cocoyl taurate;

[0080] Comparative Example 8

[0081] The difference between Comparative Example 8 and Example 1 is that the 0.28% hawthorn fruit extract in Example 1 is replaced with 0.28% piroctone olamine salt;

[0082] Test Example 1 Antibacterial test of Malassezia

[0083] After the administration treatment with Malassezia furfur, the antibacterial effect of the samples on Malassezia furfur was detected, thereby evaluating the antidandruff efficacy of the shampoo preparations of Examples 1-4 and Comparative Examples 1-4.

[0084] Malassezia furfur secretes esterase, which hydrolyzes lipids to produce inflammatory mediators such as prostaglandins, which in turn lead to inflammatory reactions, further damaging the scalp barrier and causing a large number of keratinocytes to fall off. Therefore, inhibiting Malassezia furfur can achieve the effect of removing dandruff. The antibacterial effect of the test sample on Malassezia furfur was evaluated by testing the antibacterial effect of the sample on Malassezia furfur.

[0085] Test method: (1) Test bacterial suspension range: (1.0~9.0)×10 4 CFU / ml; (2) Refer to WS / T650-2019 "Antibacterial and Antibacterial Effect Evaluation Method" 5.1.1 Suspension Quantitative Antibacterial Test. (3) Malassezia furfur quantitative test: test concentration stock solution, action time 4min, test repeated three times, take the average value. (4) Take fresh slant culture to prepare about (1.0~9.0)×10 4CFU / ml bacterial suspension was used as a substitute. 0.6mL of bacterial liquid was added to 30g of sample, and the sample was quickly shaken and timed immediately. The sample was inoculated into a culture dish, and the culture medium was poured. A control group was set up and placed in a 36℃ biochemical incubator. The results were observed for 5 days, and the live bacteria culture count was performed to calculate the antibacterial rate. The experimental results are shown in Table 1:

[0086] Table 1

[0087]

[0088]

[0089] As shown in Table 1, the antibacterial rate of Example 1-4 is significantly higher than that of Comparative Example 1-4, indicating that the shampoo preparation of the present invention has a significant inhibitory effect on Malassezia furfur, and the shampoo preparation of Comparative Example 1 does not add hawthorn fruit extract, and the inhibitory ability of Malassezia furfur decreases. Comparative Example 2 replaces hawthorn fruit extract with orientalis leaf extract, and orientalis leaf contains natural active ingredients such as volatile oil (thujene, thujone, fennel ketone), flavonoids, tannins, etc., has antimicrobial effect, has antibacterial effect on Staphylococcus aureus and Group A Streptococcus, but is weaker than Example 1-4 in the inhibitory effect on Malassezia furfur. Comparative Example 3 replaces hawthorn fruit extract with sophora flavescens root extract, and is weaker than Example 1-4 in the inhibitory effect on Malassezia furfur. In Comparative Example 4, hawthorn fruit extract, orientalis leaf extract, sophora flavescens root extract, and angelica root extract are added, and compared with Example 1-4, the product formula of Comparative Example 4 does not significantly improve the inhibitory effect on Malassezia.

[0090] Test Example 2 In vitro oil control test

[0091] The secretion of sebum is closely related to the function of sebaceous glands, and the function of sebaceous glands is closely related to the regulation of androgens. 5α-reductase is a kind of protease located in the microsomes and cell nuclei. It uses the reduced coenzyme NADPH as a hydrogen donor and can catalyze the conversion of testosterone into dihydrotestosterone. Dihydrotestosterone can induce excessive oil secretion of sebaceous glands. By inhibiting the activity of 5α-reductase, the production of dihydrotestosterone is reduced, and the level of sebaceous gland lipid secretion is reduced. Test method: Set physiological saline as a negative control, take 20 μL of each of the products of Examples 1-3 and Comparative Examples 1-7, add them to the enzyme reaction system for catalysis, measure the absorbance at 340 nm under an ultraviolet spectrophotometer, and calculate the enzyme activity by taking the average value of the absorbance. The experimental results are shown in Table 2.

[0092] Table 2

[0093]

[0094]

[0095] As shown in Table 2, compared with normal saline, each group of shampoo preparations can effectively inhibit 5α-reductase activity, among which the products of Examples 1-4 have higher inhibitory activity on 5α-reductase activity than Comparative Examples 1-8, indicating that the oil control effect of Examples 1-4 is stronger. The experimental results of Table 2 also confirm that the shampoo preparation of the present invention adopts hawthorn kernel extract and sodium lauroyl methylaminopropionate, sodium methyl cocoyl taurate, and sodium C14-C16 olefin sulfonate in a certain proportion, and synergistically produces a strong oil control effect. The lack of hawthorn kernel extract, sodium C14-C16 olefin sulfonate, sodium lauroyl methylaminopropionate, and sodium methyl cocoyl taurate ingredients reduces the inhibition of 5α-reductase activity, affecting the oil control effect of the shampoo preparation. Compared with Examples 1-4, Comparative Example 8 increases the mass ratio of piroctone ethanolamine salt, but does not significantly improve the oil control effect of shampoo.

[0096] Test Example 3: Dandruff and itch test

[0097] 120 subjects with healthy hair quality were selected, with obvious dandruff symptoms on the surface of the scalp and itchy symptoms, aged 18-40 years old, 67 men and 53 women, excluding those with perming and dyeing, alopecia areata, and pathological hair loss, and randomly divided into 12 groups. The test subjects in groups 1 to 12 used the products of Examples 1-4 and Comparative Examples 1-8 to wash their hair in turn. The washing method was uniformly as follows: wet the hair with warm water, take an appropriate amount of shampoo, gently rub the palm of your hand until there is foam, evenly apply it on the hair, gently massage the scalp and hair with your fingers, and then use Just rinse with water, wash once every 2 days, test for 3 weeks, evaluate the subjects' dandruff and scalp itching conditions on the 7th, 14th and 21st days respectively, and score according to the effects they feel after use. The dandruff test adopts a 10-point system. The higher the score, the more severe the dandruff condition. 10 points means no improvement in dandruff condition, and 0 points means complete disappearance of dandruff. The experimental results are shown in Table 3. The scalp itching test adopts a 10-point system. The higher the score, the more severe the scalp itching condition. 10 points means no improvement in scalp itching condition, and 0 points means complete disappearance of scalp itching. The experimental results are shown in Table 4.

[0098] Table 3

[0099]

[0100] Table 4

[0101]

[0102] As shown in Table 3-4, hawthorn kernel extract and sodium lauroylmethylaminopropionate, sodium methyl cocoyl taurate, and sodium C14-C16 olefin sulfonate are compounded in a certain proportion, and have a better anti-dandruff and antipruritic effect. A kind of anti-dandruff and antipruritic effect is reduced by lacking hawthorn kernel extract, sodium C14-C16 olefin sulfonate, sodium lauroylmethylaminopropionate, and sodium methyl cocoyl taurate. Although the shampoo preparations of embodiment 4 and comparative example 4 add more plant extracts, they are not significantly improved in the anti-dandruff and antipruritic effect. Malassezia is not the only reason for causing dandruff. In addition to suppressing Malassezia, a skin-friendly mild surfactant and plant extract are used to comprehensively reach a moderate but non-damaging cleaning effect of the skin, and then combined with a certain anti-inflammatory effect, scalp flora and sebum film can be maintained, and moisturizing and anti-inflammatory are taken into account, and dandruff symptoms are effectively slowed down. Comparative example 8 increases the mass ratio of piroctone olamine salt, but the anti-dandruff and antipruritic effect is not as good as the combination of hawthorn fruit extract and piroctone olamine salt. Shampoo is irritating and long-term use will cause an inflammatory reaction and severe itching on the scalp. Therefore, the itching test can also indirectly show that shampoos with better anti-itching effects after shampooing are less irritating.

[0103] Test Example 4 Moisturizing Efficacy Test

[0104] Hair is mainly composed of keratin fibers and water. The moisture content in hair is affected by the humidity of the environment, and the general content is 6-35%. The presence of water can reduce the formation of hydrogen bonds in keratin in hair, making the hair soft. When the hair is wet, the bonding effect of hydrogen bonds is reduced, which can affect the hairstyle of the hair. For example, when the hair is not dry, it is combed and maintained in a hairstyle. After the hair is dry, the hydrogen bonds in the keratin will be rearranged and fixed, so that the hairstyle can be maintained to a certain extent. Keeping the hair at a good humidity can effectively reduce the static charge on the surface of the hair, and can also effectively repair the fatty acids lost by hair care such as dyeing and perming. In terms of appearance, it can also keep the hair bright and moist, not easy to break, and can reduce the problem of hair loss. The present invention adopts an in vitro method to determine the moisturizing effect of cosmetics. Through experimental design, the test sample is compared with the positive control sample known to have moisturizing ability. If the moisturizing rate of the test sample is higher than the control moisturizing rate, it is determined that the test sample has a certain moisturizing ability.

[0105] Test method: Use an analytical balance to weigh a glass plate with 3cm adhesive tape, use a glass rod to evenly spread the sample on the glass plate with 3cm adhesive tape and record accurately, place the sample and positive control in a constant temperature and humidity drying device at 25℃ and 40% humidity and measure regularly at 0, 2, 4, 6, 8, and 24h, take out the glass plate and weigh the mass. The experimental results are shown in Table 5:

[0106] Table 5

[0107]

[0108] As shown in Table 5, compared with the positive controls of glycerol and polyethylene glycol, the products of Examples 1-3 have better moisturizing effects. If the oil control effect of the product is too strong, it will destroy the balance of the scalp flora, and the nutrients of the scalp will be easily lost during shampooing, resulting in a drier hair environment. Therefore, the product needs to have a certain moisturizing effect to make the hair appear shiny and moisturized. Changing the ingredients of the plant extracts in the product has little effect on the moisturizing effect of the product.

[0109] Test Example 5 Shampoo Test 80 female testers aged 18-40 were selected, excluding those with perm and dyeing, alopecia areata, and pathological hair loss. The 80 testers were randomly divided into 8 groups, each with 10 testers. Groups 1-8 used the shampoos made from Examples 1-4 and Comparative Examples 1-4 in turn, and washed their hair in the same way, once every 2 days, for 14 consecutive days; after the test, the testers filled out the questionnaire according to their own experience and scored the product. The scoring standard of the questionnaire was 100 points, and the higher the score, the better the effect. Finally, the average score of each shampoo was calculated, and the experimental results are shown in Table 6.

[0110] Table 6

[0111] Group Fluffy Softness Combing effect Dry effect Example 1 89 86 90 91 Example 2 92 87 88 85 Example 3 91 85 86 86 Example 4 92 86 85 88 Comparative Example 1 75 78 88 77 Comparative Example 2 68 77 85 72 Comparative Example 3 81 81 90 85 Comparative Example 4 85 77 87 87

[0112] As can be seen from Table 6, after shampooing, the products of Examples 1-4 are significantly higher than those of Comparative Examples 1-4 in terms of fluffiness, smoothness, and dryness. The shampoo preparation provided by the present invention has a better oil control effect, and can effectively reduce scalp oil after shampooing, making the hair more refreshing and fluffy. The shampoo preparation of the present invention has a good moisturizing effect, and the hair feels smoother and has a better smoothness after shampooing.

[0113] The specific embodiments described above further illustrate the purpose, technical solutions and beneficial effects of the present invention. It should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the scope of protection of the present invention. It is particularly pointed out that for those skilled in the art, any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the scope of protection of the present invention.

Claims

1. A shampoo preparation for removing dandruff and controlling oil, which comprises the following components by weight percentage: Phase A: 20-50% surfactant; Phase B: hair conditioning agent 0.83-2.34%, anti-dandruff agent 0.02-0.06%; Phase C: preservative 0.5-1.4%, essence 0.3-0.6%, thickener 0.263-0.315%, pH adjuster 0.13-0.18%, chelating agent 0.06-0.12%, the hair conditioning agent comprises hawthorn fruit extract, and the balance is water.

2. A shampoo preparation for removing dandruff and controlling oil, comprising the following components by weight percentage: phase A: 4.1-5.3% sodium lauroyl methylaminopropionate, 0.03-0.12% phenoxyethanol, 0.0025-0.01% ethylhexylglycerin, 3.8-5.0% sodium C14-C16 olefin sulfonate, 2.4-3.3% cocamidopropyl betaine, 0.5-1.2% sodium chloride, 1.36-2.05% sodium methyl cocoyl taurate, 1.4-2.4% cocamide methyl MEA, 0.08-0.31% glycerol, and the balance is water; Phase B: polyglyceryl-10 dipalmitate 0.42-0.73%, palmitamidopropyl trimethyl ammonium chloride 0.27-0.63%, sodium isostearyl lactylate 0.05-0.13%, polyquaternium-10 0.19-0.34%, anti-dandruff agent 0.02-0.06%, butylene glycol 0.001-0.005%, hawthorn fruit extract 0.15-0.36%, and the balance is water; Phase C: phenoxyethanol 0.46-0.65%, ethylhexylglycerin 0.04-0.08%, fragrance 0.3-0.6%, PEG-150 distearate 0.263-0.315%, pH adjuster 0.13-0.18%, dichlorobenzyl alcohol 0.05-0.13%, chelating agent 0.06-0.12%, and the balance is water.

3. The shampoo preparation according to claim 2, characterized in that The shampoo preparation comprises the following components in weight percentage: Phase A: Sodium lauroyl methylaminopropionate 4.5%, phenoxyethanol 0.07%, ethylhexylglycerin 0.0075%, sodium C14-C16 olefin sulfonate 4.2%, cocamidopropyl betaine 2.8%, sodium chloride 0.7%, sodium methyl cocoyl taurate 1.68%, cocamide methyl MEA 1.8%, glycerin 0.2%, the balance is water; Phase B: 0.54% polyglyceryl-10 dipalmitate, 0.57% palmitamidopropyl trimethyl ammonium chloride, 0.09% sodium isostearyl lactylate, 0.25% polyquaternium-10, 0.05% anti-dandruff agent, 0.004% butylene glycol, 0.28% hawthorn fruit extract, and the balance is water; Phase C: phenoxyethanol 0.54%, ethylhexylglycerin 0.06%, fragrance 0.4%, PEG-150 distearate 0.297%, pH adjuster 0.15%, dichlorobenzyl alcohol 0.1%, chelating agent 0.1%, and the balance is water.

4. The shampoo preparation according to claim 2, characterized in that: The anti-dandruff agent can be selected from at least one of pyrithione zinc, piroctone olamine salt, and hexamidine di(hydroxyethylsulfonate) salt.

5. The shampoo preparation according to claim 2, characterized in that The pH adjuster may be selected from at least one of citric acid, sodium citrate and arginine.

6. The shampoo preparation according to claim 2, characterized in that The chelating agent includes at least one of disodium EDTA, citric acid, sodium citrate, sodium dihydrogen phosphate, disodium hydrogen phosphate, tetrasodium etidronic acid, hydroxyethylidene diphosphonic acid, HEPES buffer, salicylic acid, sodium salicylate and diethylenetriaminepentaacetic acid.

7. The shampoo preparation according to claim 2, characterized in that: The phase B further comprises at least one of a root extract of Sophora flavescens, a root extract of Angelica sinensis, a gum of Celastrus spinulosa, a leaf extract of Platycladus orientalis, and a bark extract of Salix alba.

8. The shampoo preparation according to claim 2, characterized in that: The preparation process of the hawthorn fruit extract comprises the following steps: taking 100 portions of hawthorn fruits, removing the cores, crushing the fruits into coarse particles, adding 60% to 90% ethanol in an amount 8 to 12 times the weight ratio of the medicinal materials, heating and refluxing to extract 1 to 3 times, each time for 1 to 2 hours, filtering, combining the filtrate, and retaining the medicinal liquid; adding 6 to 10 times the weight ratio of the medicinal materials to the medicinal residues, heating and boiling to extract 1 to 3 times, each time for 1 to 2 hours, filtering, combining the filtrate, and retaining the aqueous liquid.

9. A method for preparing a shampoo preparation according to any one of claims 1 to 8, characterized in that: The preparation method comprises the following steps: 1) Weighing and adding materials: weigh the raw materials of each component in order according to the formula ratio, and add phase A into the ingredient pot; 2) Stirring and heating: Stirring and heating to 85°C, stirring and dispersing until the raw materials are evenly mixed, and continue to keep warm for 30 minutes; 3) Discharging: Keep warm and then cool down. When the temperature drops to 45°C, add phase B and stir evenly. When the temperature drops to 40°C, add phase C and stir evenly. Filter and discharge; 4) Standing: After discharging, the material is left to stand for 12 hours; 5) Testing: Take samples for testing 12 hours after discharge; 6) Filling and packaging: After the material has passed the inspection, it is filled after being sterilized; 7) Inspection and warehousing: After the finished product has passed the inspection, the raw materials are weighed according to the quality, mixed, allowed to stand, and filled.

10. Use of the shampoo preparation according to any one of claims 1 to 8 for preparing an anti-dandruff and oil-control shampoo.

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