Environment-friendly toothpaste

Abstract

The invention discloses environment-friendly toothpaste, and belongs to the field of toothpaste. The toothpaste comprises the following raw materials in parts by weight: 10-30 parts of a fish scale abrasive; 10 to 15 parts of a thickening agent; 5-10 parts of fish scale gelatin; 1-3 parts of a tooth anti-caries agent; 1-5 parts of a humectant; 0.5 to 1 part of a bacteriostatic agent; 0.5 to 1 part of an anti-allergic agent; 0.2 to 0.6 part of a preservative; and 0.1 to 0.3 part of a flavoring agent. Test results show that the toothpaste has good performance in the aspects of oral cavity antibiosis, tooth cleaning and tooth restoration, and is safe and healthy. The successful development of the fish scale toothpaste for children not only can reduce the risk of the toothpaste for children and reduce the dependence on traditional chemical raw materials, but also finds a high-valued utilization way for fish scale wastes, and realizes the cyclic utilization of resources.

Description

Technical Field

[0001] The invention relates to the field of toothpaste, in particular to an environmentally friendly toothpaste. Background Art

[0002] Oral health of young children is one of the keys to ensure their healthy growth, but data show that there are still some problems in the current children's toothpaste market: (1) Children aged 1-6 have imperfect swallowing functions and weak self-control. When brushing their teeth, they are prone to swallowing toothpaste, which may have adverse effects on children's bodies; (2) Children's immune systems are relatively weak and more sensitive to harmful substances. Children's oral mucosa is less resistant to external stimuli and is easily damaged. It is reported that the synthetic raw materials of most oral care products and the harmful substances inevitably mixed in during the synthesis of these materials may pose certain risks to children's health. After brushing teeth, there will generally be residues in the mouth. If such toothpaste is used for a long time, it may affect children's oral cavity and gastrointestinal tract, and even induce allergic reactions. Some raw materials may also significantly increase the incidence of aphthous ulcers and even have the risk of cancer; (3) The main ingredients of the current commercially available children's toothpaste are based on adult toothpaste, and only some ingredients that are harmful to children's health are reduced in dosage. Most of these ingredients that are reduced in dosage can play a role in protecting children's oral health. Doing so will inevitably weaken the protective effect. Therefore, it is very urgent to develop a safe toothpaste suitable for children. Summary of the invention

[0003] In view of the deficiencies of the prior art, the present invention provides an environmentally friendly toothpaste.

[0004] The purpose of the present invention can be achieved through the following technical solutions:

[0005] The first aspect of the present invention relates to an environmentally friendly toothpaste, comprising the following raw materials in parts by weight:

[0006] 10-30 parts of fish scale friction agent;

[0007] Thickener 10-15 parts;

[0008] 5-10 parts of fish scale gelatin;

[0009] 1-3 parts of tooth caries prevention agent;

[0010] 1 to 5 parts of moisturizer;

[0011] 0.5-1 part of antibacterial agent;

[0012] 0.5-1 part of anti-allergic agent;

[0013] 0.2-0.6 parts of preservatives;

[0014] 0.1 to 0.3 parts of flavoring agent.

[0015] Optionally, the preparation method of the fish scale abrasive comprises the following steps:

[0016] Take the spare fish scales, soak them in water, then soak them in soda ash to clean the fish scales;

[0017] Drying, crushing and grinding are performed to obtain fish scale powder;

[0018] The fish scale powder is added with pure water for ultrasonic treatment; and the fish scale friction agent is obtained after centrifugal separation.

[0019] Optionally, the method for extracting fish scale gelatin comprises the following steps:

[0020] Soak the fish scales in water, drain the water, and perform deashing until the solution is transparent, then add alkali solution and adjust the pH value to 4-6;

[0021] Acidic pepsin is added for hydrolysis, the pH is adjusted to neutral, neutral Bacillus subtilis protease is added for enzymolysis, and then the temperature is raised to boiling for inactivation;

[0022] Add activated carbon, stir and soak, then centrifuge to obtain a clear liquid, concentrate and evaporate it, and obtain the fish scale gelatin.

[0023] The alkali solution may also be the alkali solution produced during the preparation of the aforementioned fish scale friction agent.

[0024] Optionally, the humectant comprises sorbitol.

[0025] Optionally, the dental anticaries agent comprises xylitol.

[0026] Optionally, the preservative includes sodium benzoate and / or edible VC.

[0027] Optionally, the natural antibacterial agent and anti-allergic agent include chitosan and natural tea seed powder, respectively.

[0028] Optionally, the flavoring agent includes strawberry extract, the thickening agent includes potato starch colloid, and coconut oil is further included as a foaming agent.

[0029] The second aspect of the present invention relates to a method for preparing an environmentally friendly toothpaste, comprising the following steps:

[0030] Measure the calculated amount of pure water, stir and dilute the weighed moisturizer, anti-caries agent, preservative, natural antibacterial agent, and potato starch respectively, and use a water bath to keep the remaining water at a temperature of 85°C-95°C;

[0031] The diluted potato starch liquid is added to the pure water under stirring condition as a thickener; the extracted fish scale gelatin is added to the thickener; then the diluted moisturizer, anti-caries agent, preservative and natural antibacterial agent are added and stirred; then the fish scale abrasive and foaming agent are added under stirring condition and stirred evenly to obtain the environmentally friendly toothpaste.

[0032] The third aspect of the present invention relates to the use of the above-mentioned environmentally friendly toothpaste in cleaning teeth, inhibiting bacteria and repairing teeth.

[0033] Beneficial effects of the present invention:

[0034] The present invention uses fish scales to extract abrasives and gelatin to produce an innovative method for environmentally friendly toothpaste for children. This toothpaste can not only meet the basic function of cleaning the mouth and teeth, but also ensure the health and safety of children's toothpaste. In addition, this toothpaste also finds a way to increase the value of fish scale waste, realize the recycling of resources, and reduce environmental pollution. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] The present invention will be further described below in conjunction with the accompanying drawings.

[0036] Figure 1 The manufacturing flow chart of the children's fish scale toothpaste of this application;

[0037] Figure 2 This is a diagram of the fish scale abrasive extraction process of the present application;

[0038] Figure 3 The gelatin preparation process of the children's fish scale toothpaste of this application;

[0039] Figure 4 A diagram showing the configuration process of the children's fish scale toothpaste of the present application;

[0040] Figure 5 This is the test diagram of the properties of the children's fish scale toothpaste for this application;

[0041] Figure 6 A blank control sample for the cleaning ability test containing only artificial simulated saliva in this application;

[0042] Figure 7 The cleaning ability test results of the children's fish scale toothpaste of this application;

[0043] Figure 8 A comparison chart of the cleaning ability test results of a certain brand of toothpaste and the children's fish scale toothpaste of the present application;

[0044] Fig. 9 This is a test chart of the antibacterial ability of the children's fish scale toothpaste of this application;

[0045] Fig.10This is the experiment of repairing egg scratches with the children's fish scale toothpaste of this application;

[0046] Fig.11 This is the copper loss value test diagram for this application;

[0047] Fig.12 This is the copper consumption value test chart of the blank sample of this application;

[0048] Fig.13 This is a test chart of the copper consumption value of the children's fish scale toothpaste of this application;

[0049] Fig.14 This is a graph showing the change in surface roughness of a copper plate before and after the children's fish scale toothpaste friction experiment of this application;

[0050] Fig.15 This is a SEM microstructure diagram of the fish scale of this application;

[0051] Fig.16 This is the XRD diagram of the fish scale friction agent of this application. DETAILED DESCRIPTION

[0052] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0053] In some embodiments of the present invention, a method for preparing and developing an environmentally friendly children's toothpaste is disclosed, which may include the following process:

[0054] 1 Based on the composition of children's fish scale toothpaste, design a flow chart for manufacturing fish scale toothpaste, such as Figure 1 shown.

[0055] 2. Toothpaste formula optimization: According to the characteristics of the extracted fish scale abrasive and gelatin, add appropriate amounts of thickeners, moisturizers, foaming agents, antibacterial agents, flavoring agents, etc. to prepare 20g toothpaste samples, and determine the optimal formula ratio through repeated experiments.

[0056] 3. Evaluation of sensory and physical and chemical indicators of toothpaste (refer to the current national standard for toothpaste GB / T 8372-2017)

[0057] According to national standards, the toothpaste texture, mildness (pH value), stability and foaming conditions are tested.

[0058] In some more specific embodiments, a specific preparation method and testing method of toothpaste are disclosed, comprising the following steps:

[0059] 1. Cleaning of fish scales

[0060] ① The first cleaning (removal of impurities): select impurities, stir and clean 50g grass carp scales with 150ml tap water for 3min, and drain the water;

[0061] ② Second cleaning (degreasing and removing fishy smell): add 10g homemade flour detergent (18.5% flour + 0.1% soda ash

[0062] +2.5% sodium alginate +2.5% gelatin +1.5% potassium sorbate), add 150ml tap water, stir and wash for 3min, and control the water;

[0063] ③ The third cleaning (removing oil and fishy smell): add 4.5g edible soda ash, add 150ml tap water, stir and clean for 3 minutes, and control the water;

[0064] ④ For the first cleaning after alkali treatment, add 150ml of tap water, stir and clean for 3 minutes, and control the water;

[0065] ⑤ After alkali, wash for the second time, add 150ml of tap water, stir and wash for 3 minutes, and control the water;

[0066] ⑥ After alkali, wash for the third time, add 150ml of tap water, stir and wash for 3 minutes, and control the water;

[0067] ⑦ Clean the fish scales, drain the water, and freeze them for later use.

[0068] 2 Extraction of Friction Agent

[0069] ① Degumming: Take 50g of spare fish scales, add 150ml of tap water and soak for 30min, add 4.5g of soda ash, and heat at 40-50℃

[0070] Under the conditions, soak for 12h (overnight), control the water, add 150ml 50℃ hot water and wash it several times;

[0071] ② Drying: Bake the fish scales at 150℃ for 12h;

[0072] ③ Crushing: crush the dried fish scales with a crusher;

[0073] ④ Grinding: Grind the crushed fish scales with a grinding pestle for 30 minutes, select a 200-mesh nylon mesh for screening, and examine the effect of abrasives on the performance of toothpaste under filtering with different mesh sizes.

[0074] ⑤Ultrasonic treatment: add fish scale powder to pure water and ultrasonicate (under the condition of 40-50℃, 40KHz, 100w ultrasonic treatment for 20min);

[0075] ⑥ Centrifugal separation: centrifuge the fish scale powder liquid after ultrasound for 3 minutes; use a syringe to extract the supernatant and remove the remaining solid powder. Grind until the powder is completely dispersed, dry it, and make it into fish scale friction agent for use. The extraction process is as follows: Figure 2 shown.

[0076] 3. Gelatin extraction

[0077] ① Deliming: Take 50g of spare fish scales, soak them in water for 30min, control the water, and perform deliming treatment until the solution is transparent, add the alkaline degumming solution used to extract the abrasive (this step can neutralize the acidic deliming agent and the gelatin in the degumming solution can be used), and adjust the pH value to 4-6;

[0078] ②Protease hydrolysis: add 0.1%-0.5% of the weight of fish scales acidic pepsin, enzymolysis for 12 hours (overnight) at 30℃-40℃, adjust the pH to neutral, add 0.1%-0.5% of neutral Bacillus subtilis protease, enzymolysis for 12 hours (overnight) at 30℃-40℃, then heat to boiling, inactivate, and cool to 30℃-40℃;

[0079] ③ Deodorization and decolorization: Add activated carbon at a ratio of 1%-3% of the clear liquid mass, stir, and soak for 30 minutes;

[0080] ④ Centrifugal separation: Centrifuge the decolorized liquid for 3 minutes and take the clear liquid;

[0081] ⑤ Boil: Concentrate and evaporate to 10-30%, cool and set aside. The extraction process is as follows Figure 3 shown.

[0082] 4. Formulation Optimization

[0083] This embodiment selects the extracted fish scale ash as a toothpaste abrasive, uses potato starch colloid and gelatin colloid extracted from fish scales as a thickener; uses safer sorbitol as a moisturizer, selects xylitol as a tooth caries preventive, selects chitosan and natural tea seed powder as a natural antibacterial agent and anti-allergic agent for toothpaste, and selects food-grade sodium benzoate and edible VC as a preservative. Finally, strawberry extract is selected as a flavoring agent. According to a large number of experiments and tests, the optimal ratio of the fish scale toothpaste after optimization in this project is shown in Table 1.

[0084] Table 1 Proportions of homemade toothpaste

[0085]

[0086]

[0087] 5 Preparation steps

[0088] Preparation process of children's fish scale toothpaste Figure 4 shown.

[0089] 6. Test for compliance with national standards for homemade toothpaste

[0090] The general properties of homemade toothpaste are shown in Table 2:

[0091] Table 2 Properties of homemade toothpaste

[0092] color Characteristics pH odor taste Bubble situation Beige Paste 6.87 Strawberry flavor Slightly sweet The bubbles are dense, small and delicate

[0093] According to the national standard "Toothpaste" GB / T 8372-2017, we tested the compliance of the homemade children's fish scale toothpaste with the national standard. The statistical results are shown in Table 3. Figure 5 From the test results, it can be seen that the indicators of children's fish scale toothpaste meet the national standards, and some items are even better than the national standards.

[0094] Table 3 National standard compliance test table for homemade children's toothpaste

[0095]

[0096] 7. Cleaning ability test

[0097] Take a colored egg and use a carbon pen to draw a line along the middle of the egg, dividing it into left and right sides. Keep one side still and use a toothbrush to dip artificial simulated saliva on the other side and rub it back and forth on the surface of the egg 10 times (one back and forth counts as one time) as a blank comparison sample. The test results are as follows: Figure 6 The left side (L) shows the original state of the dyed egg, and the right side (R) shows it being brushed with a toothbrush containing only artificial simulated saliva. It can be seen from the figure that the toothbrush containing only artificial simulated saliva has limited cleaning ability for the dyed egg, and the surface of the dyed egg only fades slightly.

[0098] Take another dyed egg and use a carbon pen to draw a line along the middle of the egg, dividing it into two sides. Keep one side still and squeeze 1g of fish scale toothpaste on the toothbrush on the other side. Rub it back and forth on the surface of the egg 10 times (one back and forth counts as one time). The test results are as follows: Figure 7 shown.

[0099] As can be seen from the picture, fish scale toothpaste can obviously erase the color of the surface of dyed eggs. The test results show that children's fish scale toothpaste has excellent cleaning ability for dyed eggs.

[0100] Take another dyed egg and use a carbon pen to draw a line along the middle of the egg to divide it into two sides. Squeeze 1g of Crest Whitening Toothpaste on one side and 1g of Children's Fish Scale Toothpaste on the other side. Rub them back and forth on the surface of the egg 10 times. The test results are as follows: Figure 8 shown.

[0101] From the results in the figure, we can see that compared with Crest Whitening Toothpaste, Fish Scale Toothpaste has the same excellent cleaning ability.

[0102] 8Oral antibacterial ability test

[0103] According to the antibacterial performance test instructions, the areas with bacterial colonies will show red on the test paper. The more red dots there are, the more bacterial colonies there are. Fig. 9 The test results show that this children's fish scale toothpaste has excellent antibacterial properties.

[0104] 9Simulation evaluation of the effect of fish scale toothpaste on tooth repair in children

[0105] This example uses the repair of egg scratches to simulate the evaluation of toothpaste repair on teeth. Wear a thick cotton glove on your left hand, take a boiled and cooled egg, dip a little white vinegar with the tip of a utility knife in your right hand, and carefully scratch a 10*10 grid on the eggshell, with the distance between every two lines being about 0.2mm and the depth being about 1mm.

[0106] Obviously, from Fig.10 It can be seen that the depth of the scratched area of ​​the egg after immersion in toothpaste liquid for 172 hours has become significantly shallower, which shows that fish scale toothpaste has a certain repair function for the damaged eggshell surface. Since the main chemical composition of eggshell and human teeth is similar, it can be inferred that fish scale toothpaste may also have a certain repair ability for damaged teeth.

[0107] 10Allergy Test

[0108] Recruit 10 volunteers, aged from 2 to 79 years old, 6 females and 4 males. Take 1g of homemade toothpaste and apply it evenly on the wrist and behind the ear of the volunteers for 30 minutes each. Observe whether the skin surface of the volunteers is red, swollen, etc., and ask the volunteers whether they have discomfort, itching and other allergic phenomena. The test results are shown in Table 4: From the test statistical results, it can be seen that the 10 volunteers of different ages and genders did not have allergic reactions to fish scale toothpaste.

[0109] Table 4 Statistics of volunteers' allergy to fish scale toothpaste

[0110] Volunteer Name Applying position Are you allergic? Applying position Are you allergic? Zhang**(2 years old, female) wrist × Behind the ears × Wang*(3 and a half years old, male) wrist × Behind the ears × Wang**(5 years old, male) wrist × Behind the ears × Gao**(12 years old, female) wrist × Behind the ears × Liu**(12 years old, male) wrist × Behind the ears × Jiang**(12 years old, male) wrist × Behind the ears × Li**(41 years old, female) wrist × Behind the ears × Wang**(43 years old, male) wrist × Behind the ears × Li**(79 years old, male) wrist × Behind the ears × Lu**(75 years old, female) wrist × Behind the ears ×

[0111] 11. Copper loss value and Ra test

[0112] The better the cleaning power of the abrasive, the greater the wear and tear on teeth. In the international toothpaste standard ISO11609, the wear assessment of toothpaste abrasives on teeth generally adopts the concept of wear value (RDA). The higher the wear value, the greater the wear of the abrasive on teeth. Since the determination of the RDA value is relatively complicated and the experimental requirements are relatively high, there are currently almost no professional testing institutions in China to determine the RDA value. Data show that compared with the RDA value, the determination of the copper consumption value is more convenient and more operational, and there is a certain positive relationship between the RDA value and the copper consumption value. Therefore, this experiment uses the copper consumption value to study the cleaning performance and wear of the fish scale abrasive, in order to study the wear of teeth after long-term use of this toothpaste. Homemade testing equipment such as Fig.11 As shown. At the same time, this embodiment also tests the surface roughness (Ra) of the copper plate. Under normal conditions, the higher the copper loss value, the greater the degree of damage that the toothpaste may cause to the teeth. Ra is the arithmetic mean roughness, which represents the absolute value of the roughness on the reference length, and is the average value of the height deviation of each point on the surface from the average height. The higher Ra, the rougher the surface of the object.

[0113] Choose not to add toothpaste ingredients, only add 2ml of artificial simulated saliva, and rub the test toothbrush back and forth on the copper plate 10,000 times as a blank comparison sample. Fig.12 The test adds 1g of the toothpaste and 1ml of artificial saliva, and tests the copper consumption value after the toothbrush is rubbed back and forth on the copper plate 10,000 times. Fig.13 As shown, the roughness of the copper plate before and after friction was tested, and the results are as follows Fig.14 shown.

[0114] From the blank sample test results, in the absence of toothpaste, the copper consumption value of the toothbrush after 10,000 frictions is 1 mg. Generally speaking, the copper consumption value of ordinary toothpaste abrasives is within 2.0 mg; the copper consumption value of medium-friction toothpaste is between 2.0 and 10.0 mg; the copper consumption value of high-friction toothpaste is greater than 10.0 mg, and it is generally better not to exceed 20.0 mg, otherwise it is easy to wear the tooth enamel.

[0115] According to the test results, the copper consumption value of children's fish scale toothpaste is 8mg. After deducting the blank background of 1g, the net copper consumption value of this toothpaste is 7mg, which is medium friction ability. It is not easy to damage teeth with long-term use, which shows that this toothpaste is safe for long-term use. According to the test of the surface roughness of the copper plate, it can be seen that the surface roughness of the copper plate is significantly reduced after the friction test with fish scale toothpaste, and the surface becomes smooth.

[0116] The microscopic morphology of fish scales is shown in SEM photos. Fig.15As shown, the left picture is a low-power view, and the right picture is a high-power view. It can be seen from the picture that the fish scale particles are irregular and angular, and the edges and corners are blunt. The microstructure of the fish scale verifies the copper consumption value experiment of the fish scale toothpaste. Its friction ability is moderate and long-term use will not cause damage to teeth.

[0117] In order to clarify the composition of fish scale friction agent, the fish scale friction agent was subjected to XRD test, and the results are as follows: Fig.16 As shown in the figure, the main component of the fish scale friction agent is hydroxyapatite (Ca 5 (PO 4 ) 3 (OH)). Since hydroxyapatite can be used as an induction factor for bones or teeth, it has a good remineralization effect on teeth in the field of oral health care. The XRD test results verify the experiment that fish scale toothpaste has a repairing effect on scratched eggshells. It can also be inferred from the side that fish scales can promote the repair of teeth.

[0118] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0119] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments, and the above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, and these changes and improvements all fall within the scope of the present invention to be protected.

Claims

1. An environmentally friendly toothpaste, characterized in that: It includes the following raw materials in parts by weight: 10-30 parts of fish scale friction agent; Thickener 10-15 parts; 5-10 parts of fish scale gelatin; 1 to 3 parts of tooth caries prevention agent; 1 to 5 parts of moisturizer; 0.5-1 part of antibacterial agent; 0.5-1 part of anti-allergic agent; 0.2-0.6 parts of preservatives; 0.1 to 0.3 parts of flavoring agent.

2. The environmentally friendly toothpaste according to claim 1, characterized in that: The preparation method of the fish scale friction agent comprises the following steps: Take the spare fish scales, soak them in water, then soak them in soda ash to clean the fish scales; Drying, crushing and grinding are performed to obtain fish scale powder; The fish scale powder is added with pure water for ultrasonic treatment; and the fish scale friction agent is obtained after centrifugal separation.

3. The environmentally friendly toothpaste according to claim 1, characterized in that: The method for extracting fish scale gelatin comprises the following steps: Soak the fish scales in water, drain the water, and perform deashing until the solution is transparent, then add alkali solution and adjust the pH value to 4-6; Acidic pepsin is added for hydrolysis, the pH is adjusted to neutral, neutral Bacillus subtilis protease is added for enzymolysis, and then the temperature is raised to boiling for inactivation; Add activated carbon, stir and soak, then centrifuge to obtain a clear liquid, concentrate and evaporate it, and obtain the fish scale gelatin.

4. The environmentally friendly toothpaste according to claim 1, characterized in that: The humectant includes sorbitol.

5. The environmentally friendly toothpaste according to claim 1, characterized in that: The dental anticaries agent includes xylitol.

6. The environmentally friendly toothpaste according to claim 1, characterized in that: The preservatives include sodium benzoate and / or edible VC.

7. The environmentally friendly toothpaste according to claim 1, characterized in that: The natural antibacterial agent and anti-allergic agent include chitosan and natural tea seed powder respectively.

8. The environmentally friendly toothpaste according to claim 1, characterized in that: The flavoring agent includes strawberry extract, the thickening agent includes potato starch colloid, and coconut oil is also included as a foaming agent.

9. A method for preparing an environmentally friendly toothpaste, comprising the following steps: Measure the calculated amount of pure water, stir and dilute the weighed moisturizer, anti-caries agent, preservative, natural antibacterial agent, and potato starch respectively, and use a water bath to keep the remaining water at a temperature of 85°C-95°C; The diluted potato starch solution is added to the purified water under stirring as a thickener; the extracted fish scale gelatin is added to the thickener; and the diluted moisturizer, anti-caries agent, preservative, and natural antibacterial agent are added and stirred; Then, the fish scale abrasive and the foaming agent are added under stirring conditions, and the mixture is stirred evenly to obtain the environmentally friendly toothpaste.

10. Use of the environmentally friendly toothpaste according to any one of claims 1 to 8 in cleaning teeth, inhibiting bacteria and repairing teeth.

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