Medicinal and edible composite effervescent tablet for treating gout as well as preparation method and application of medicinal and edible composite effervescent tablet

Abstract

The invention relates to the technical field of effervescent tablets, and particularly discloses a medicinal and edible composite effervescent tablet for treating gout as well as a preparation method and application of the medicinal and edible composite effervescent tablet. The medicinal and edible composite effervescent tablets are prepared from the following raw materials: 10-30 parts of a honeysuckle extract, 10-30 parts of a Chinese olive extract, 10-30 parts of a gardenia extract, 10-30 parts of a dandelion extract, 3-8 parts of a disintegrating agent, 5-10 parts of a sweetening agent, 1-5 parts of a filling agent, 2-5 parts of a wetting agent, 15-30 parts of an acid source and 25-40 parts of an alkali source. According to the prepared medicinal and edible composite effervescent tablet, traditional Chinese medicine components with gout treatment effects are organically combined with nutrients, and a safe and effective new dietary therapy choice is provided for patients.

Description

Technical Field

[0001] The invention relates to the technical field of effervescent tablets, and more specifically to a medicinal and edible composite effervescent tablet for treating gout, and a preparation method and application thereof. Background Art

[0002] In recent years, with the profound changes in global lifestyles, the prevalence of gout has shown a sharp upward trend worldwide, and has evolved into a public health issue that poses a major challenge to human health. The present invention is deeply rooted in the field of traditional Chinese medicine, especially focusing on the vast world of traditional Chinese medicine that is both medicinal and edible. Against this background, the innovative development and unique advantages of traditional Chinese medicine have become increasingly prominent, attracting widespread attention and in-depth application around the world.

[0003] At present, the mainstream treatment options for gout on the market mostly rely on Western medicine, such as allopurinol and colchicine. Although these drugs have shown certain effectiveness in relieving gout symptoms, their significant side effects pose a potential threat to the patient's health. Traditional Chinese medicine has shown unique advantages in the field of gout treatment. It is not only effective and reliable, but also excellent in terms of drug safety. In particular, the application of traditional Chinese medicine that is both medicinal and edible has opened up a new treatment path for gout patients and has attracted much attention.

[0004] In this context, dietary alternatives have gradually become a hot topic in gout treatment research. As a novel dosage form with excellent taste and high bioavailability, effervescent tablets have the unique advantage of perfectly integrating the edible and medicinal values ​​of the raw materials, thereby providing significant health care functions while supplementing nutrition. The research and development of medicinal and edible composite effervescent tablets is based on this concept, aiming to organically combine a variety of traditional Chinese medicine ingredients with gout treatment effects with nutrients through scientific proportions and advanced processes, providing patients with a new dietary therapy option that is both safe and effective. This innovation not only enriches the means of gout treatment, but also makes an important contribution to promoting the modernization and international development of traditional Chinese medicine.

[0005] However, it is difficult to select Chinese medicinal materials for the food-medicinal composite effervescent tablets, and it is difficult for the Chinese medicinal materials to cooperate with each other to exert better therapeutic effects. Summary of the invention

[0006] The invention provides a composite effervescent tablet of both medicinal and edible properties for treating gout, and a preparation method and application thereof. The prepared composite effervescent tablet of both medicinal and edible properties organically combines traditional Chinese medicine components with gout therapeutic effects with nutrients, providing patients with a new diet therapy option that is both safe and effective.

[0007] In a first aspect, the present invention provides a medicinal and edible composite effervescent tablet for treating gout, which is made from the following raw materials: 10-30 parts of honeysuckle extract, 10-30 parts of green fruit extract, 10-30 parts of gardenia extract, 10-30 parts of dandelion extract, 3-8 parts of disintegrant, 5-10 parts of sweetener, 1-5 parts of filler, 2-5 parts of wetting agent, 15-30 parts of acid source, and 25-40 parts of alkali source.

[0008] Preferably, it is made from the following raw materials: 20-30 parts of honeysuckle extract, 20-30 parts of green fruit extract, 20-30 parts of gardenia extract, 10-20 parts of dandelion extract, 3-5 parts of disintegrant, 8-10 parts of sweetener, 2-5 parts of filler, 4-5 parts of wetting agent, 20-30 parts of acid source, and 25-30 parts of alkali source.

[0009] Preferably, it is made from the following raw materials: 30 parts of honeysuckle extract, 30 parts of green fruit extract, 30 parts of gardenia extract, 20 parts of dandelion extract, 5 parts of disintegrant, 10 parts of sweetener, 5 parts of filler, 5 parts of wetting agent, 30 parts of acid source, and 30 parts of alkali source.

[0010] Preferably, the extraction method of honeysuckle extract is: crush the honeysuckle, perform reflux extraction with ethanol as solvent, usually multiple extractions are required, and the extract is concentrated by a rotary evaporator, and finally the extract is obtained by drying.

[0011] Honeysuckle extract can inhibit a variety of inflammatory factors and enhance the activity of interleukins. Flavonoids and other antioxidant components in honeysuckle extract can scavenge free radicals and protect cells from oxidative damage. Honeysuckle extract can lower serum total cholesterol and triglyceride levels, helping to improve hyperlipidemia. Honeysuckle extract has an inhibitory effect on a variety of viruses and can be used to prevent and treat viral infections. Honeysuckle extract can regulate the immune system and enhance the body's immunity.

[0012] Preferably, the extraction method of the green fruit extract is: using supercritical CO 2 As the extractant, the extraction is carried out at 35-45°C and a pressure of 300-500 bar.

[0013] Green fruit extract is rich in polyphenols, flavonoids and triterpenoids, which have significant antioxidant capacity, can remove free radicals in the body, delay cell aging, and thus play an anti-aging and cardiovascular protective role. Green fruit extract has shown good anti-inflammatory effects in in vitro and in vivo experiments. Studies have shown that green fruit extract can inhibit the activity of key enzymes in inflammatory responses such as α-glucosidase and α-amylase, thereby reducing inflammation. Green fruit extract has an inhibitory effect on a variety of pathogenic bacteria (such as Staphylococcus aureus and Escherichia coli), which makes it have potential application value in the development of antibacterial drugs. Green fruit extract can protect the liver from damage by alcohol and toxic substances (such as carbon tetrachloride) and help to sober up.

[0014] Preferably, the method for extracting the gardenia extract is: using ultrasonic extraction method, using the mechanical oscillation of ultrasound to destroy the cell wall of the gardenia, accelerating the extraction process, and extracting the extract.

[0015] Ingredients such as geniposide and gardenia glycoside in gardenia extract have significant anti-inflammatory effects. These ingredients can inhibit the production and release of inflammatory mediators, reduce tissue damage and pain. Animal experiments have shown that gardenia extract has a good therapeutic effect on inflammatory diseases such as experimental arthritis and colitis. Flavonoids in gardenia extract have strong antioxidant activity, can scavenge free radicals, inhibit lipid peroxidation, and protect cells from oxidative damage. This makes gardenia extract have certain application potential in the prevention and treatment of cardiovascular diseases, diabetes, etc. Gardenia extract has an inhibitory effect on a variety of tumor cells.

[0016] Preferably, the extraction method of dandelion extract is: dissolving dandelion raw material in ethanol and ether organic solvent, and extracting at 75° C., ethanol concentration of 65%, and solid-liquid ratio of 1:30.

[0017] Dandelion is bitter, sweet and cold in nature, and has the effects of clearing away swelling, clearing away heat and detoxifying, inhibiting bacteria, and clearing away dampness and heat. It can inhibit a variety of bacteria in the mouth, including pathogenic streptococci. Dandelion extract also has anti-inflammatory properties. This makes dandelion extract an effective auxiliary ingredient, and dandelion extract has the effect of clearing heat and detoxifying.

[0018] In a second aspect, the present invention provides a method for preparing a medicinal and edible composite effervescent tablet for treating gout, comprising the following steps:

[0019] (1) preparing honeysuckle extract, green fruit extract, gardenia extract and dandelion extract through an extraction process, and then concentrating the honeysuckle extract, green fruit extract, gardenia extract and dandelion extract through a concentration process, mixing them according to a certain proportion, and preparing a traditional Chinese medicine extract;

[0020] (2) adding a disintegrant, a sweetener, a filler and a wetting agent to a traditional Chinese medicine extract to obtain a mixture through a drying process;

[0021] (3) adding an acid source and an alkali source to the mixture, mixing to prepare a soft material, mixing and tableting, and preparing a medicinal and edible composite effervescent tablet for treating gout through a molding process.

[0022] Preferably, in step (1), the extraction process is determined by a single factor method to determine the solid-liquid ratio, single extraction time and number of extractions; and the concentration process is one of atmospheric pressure concentration and reduced pressure concentration.

[0023] Preferably, in step (1), the mass ratio of honeysuckle extract, green fruit extract, gardenia extract and dandelion extract is (1-3): (1-3): (1-3): (1-3).

[0024] Preferably, in step (2), the drying process is one of vacuum drying, freeze drying and normal pressure drying.

[0025] Preferably, in step (3), the molding process determines the amount of extract added, the amount of disintegrant added, the ratio of disintegrant and the amount of sweetener added by a single factor method.

[0026] Preferably, the extraction process is carried out according to a solid-liquid ratio of 1:12, with two extractions and a single extraction time of 1.5 hours to obtain a medicinal solution, which is concentrated under reduced pressure at 80° C. and vacuum dried to obtain a traditional Chinese medicine extract.

[0027] Preferably, the effervescent tablet is prepared by separate granulation of acid and base, and the specific preparation process is as follows:

[0028] Crush the sodium bicarbonate and citric acid separately, pass through a 80-mesh sieve for later use, mix the Chinese medicine extract, lactose and sweetener evenly and divide them into two parts, respectively make a soft material with sodium bicarbonate and citric acid using 95% ethanol, dry at 55°C to obtain dry granules, sieve through a 24-mesh sieve and press into tablets.

[0029] In a third aspect, the present invention provides a use of a composite effervescent tablet in the preparation of a medicament for treating gout.

[0030] In summary, the present invention has the following beneficial effects:

[0031] 1. The gardenia contained in the present invention can reduce inflammatory factors: Gardenia glycoside can reduce inflammatory response, relieve pain and kill bacteria;

[0032] 2. The gardenia contained in the present invention can reduce the activity of xanthine oxidase: Gardenia glycoside can effectively reduce the activity of xanthine oxidase, thereby reducing the synthesis of uric acid;

[0033] 3. The medicinal and edible composite effervescent tablets for treating gout of the present invention is a relatively outstanding product. This product is based on the concept of "medicine and food are of the same origin". It assists in lowering uric acid levels and reducing the frequency of gout attacks through mechanisms such as alkalizing urine and dissolving crystals to protect the kidneys. It also has the function of protecting the kidneys and improving renal function. Its main ingredients include honeysuckle extract, green fruit extract, gardenia extract and dandelion extract. These ingredients can effectively resist oxidation, anti-inflammatory and analgesic, and are suitable for people with gout and kidney stones.

[0034] It should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not intended to limit the scope of protection of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 It is a bar graph of the uric acid content in rat serum of the medicinal and edible composite effervescent tablets for treating gout prepared in the embodiment of the present invention;

[0036] Figure 2 It is a bar graph of the IL-1β level of the medicinal and edible composite effervescent tablet for treating gout prepared in an embodiment of the present invention in rats;

[0037] Figure 3 This is a data graph of the swelling degree of the ankle joint of rats using the medicinal and edible composite effervescent tablets for treating gout prepared in an embodiment of the present invention. DETAILED DESCRIPTION

[0038] The present invention is further described in detail below in conjunction with the examples. It is particularly noted that if no specific conditions are specified in the following examples, the reactions are carried out according to conventional conditions or conditions recommended by the manufacturer. Unless otherwise specified, the raw materials used in the following examples can be obtained from common commercial sources.

[0039] The extraction method of honeysuckle extract is as follows: after crushing the honeysuckle, reflux extraction is performed using ethanol as a solvent, which usually requires multiple extractions, and the extract is concentrated by a rotary evaporator, and finally the extract is obtained by drying.

[0040] The extraction method of green fruit extract is: using supercritical CO 2 As the extractant, the extraction is carried out at 35-45°C and a pressure of 300-500 bar.

[0041] The extraction method of the gardenia extract is: adopting the ultrasonic extraction method, utilizing the mechanical oscillation of ultrasound to destroy the cell wall of the gardenia, accelerating the extraction process, and extracting the extract.

[0042] The extraction method of dandelion extract is as follows: dissolving dandelion raw material in ethanol and ether organic solvents, and extracting at 75°C, ethanol concentration of 65%, and solid-liquid ratio of 1:30.

[0043] Example

[0044] Example 1

[0045] A medicinal and edible composite effervescent tablet for treating gout is prepared from the following raw materials: 10 parts of honeysuckle extract, 10 parts of green fruit extract, 10 parts of gardenia extract, 10 parts of dandelion extract, 3 parts of disintegrant, 5 parts of sweetener, 1 part of filler, 2 parts of wetting agent, 15 parts of acid source and 25 parts of alkali source.

[0046] The preparation method of the medicinal and edible composite effervescent tablet for treating gout comprises the following steps:

[0047] (1) preparing honeysuckle extract, green fruit extract, gardenia extract and dandelion extract through an extraction process, and then concentrating the honeysuckle extract, green fruit extract, gardenia extract and dandelion extract through a concentration process, and mixing them in a mass ratio of 1:1:2:3 to prepare a traditional Chinese medicine extract;

[0048] (2) adding a disintegrant, a sweetener, a filler and a wetting agent to a traditional Chinese medicine extract to obtain a mixture through a drying process;

[0049] (3) adding an acid source and an alkali source to the mixture, mixing to prepare a soft material, mixing and tableting, and preparing a medicinal and edible composite effervescent tablet for treating gout through a molding process.

[0050] Example 2

[0051] A medicinal and edible composite effervescent tablet for treating gout is prepared from the following raw materials: 20 parts of honeysuckle extract, 20 parts of green fruit extract, 20 parts of gardenia extract, 10 parts of dandelion extract, 5 parts of disintegrant, 8 parts of sweetener, 3 parts of filler, 3 parts of wetting agent, 20 parts of acid source and 30 parts of alkali source.

[0052] The preparation method of the medicinal and edible composite effervescent tablet for treating gout comprises the following steps:

[0053] (1) preparing honeysuckle extract, green fruit extract, gardenia extract and dandelion extract through an extraction process, and then concentrating the honeysuckle extract, green fruit extract, gardenia extract and dandelion extract through a concentration process, mixing them in a mass ratio of 2:2:2:1 to prepare a traditional Chinese medicine extract;

[0054] (2) adding a disintegrant, a sweetener, a filler and a wetting agent to a traditional Chinese medicine extract to obtain a mixture through a drying process;

[0055] (3) adding an acid source and an alkali source to the mixture, mixing to prepare a soft material, mixing and tableting, and preparing a medicinal and edible composite effervescent tablet for treating gout through a molding process.

[0056] Example 3

[0057] A medicinal and edible composite effervescent tablet for treating gout is prepared from the following raw materials: 30 parts of honeysuckle extract, 30 parts of green fruit extract, 30 parts of gardenia extract, 20 parts of dandelion extract, 8 parts of disintegrant, 10 parts of sweetener, 5 parts of filler, 5 parts of wetting agent, 30 parts of acid source and 40 parts of alkali.

[0058] The preparation method of the medicinal and edible composite effervescent tablet for treating gout comprises the following steps:

[0059] (1) preparing honeysuckle extract, green fruit extract, gardenia extract and dandelion extract through an extraction process, and then concentrating the honeysuckle extract, green fruit extract, gardenia extract and dandelion extract through a concentration process, mixing them in a mass ratio of 3:3:3:2 to prepare a traditional Chinese medicine extract;

[0060] (2) adding a disintegrant, a sweetener, a filler and a wetting agent to a traditional Chinese medicine extract to obtain a mixture through a drying process;

[0061] (3) adding an acid source and an alkali source to the mixture, mixing to prepare a soft material, mixing and tableting, and preparing a medicinal and edible composite effervescent tablet for treating gout through a molding process.

[0062] Comparative Example 1

[0063] The composite effervescent tablet was prepared according to the method of Example 2, except that no honeysuckle extract was added.

[0064] Comparative Example 2

[0065] The composite effervescent tablet was prepared according to the method of Example 2, except that no green fruit extract was added.

[0066] Comparative Example 3

[0067] The composite effervescent tablet was prepared according to the method of Example 2, except that the gardenia extract was not added.

[0068] 1. Conduct in vitro xanthine oxidase inhibition experiment

[0069] The experiment was divided into a Chinese medicine group (Chinese medicine extract + enzyme + substrate), a positive control group (allopurinol + enzyme + substrate), a Chinese medicine control group (Chinese medicine + substrate), a model group (enzyme + substrate), and a blank group (substrate only). Five concentration gradients were set for each group, and dimethyl sulfoxide was used as the solvent for the lyophilized powder to prepare the Chinese medicine extract. The reaction system was 200 μL in total, and PBS was used to supplement the insufficient volume.

[0070] The mixture of PBS, Chinese herbal extract or allopurinol, and enzyme was incubated at 37°C for 15 min, and then the xanthine substrate solution was added and incubated at 37°C for another 15 min. Three parallel experiments were performed in each group, and the enzymatic conversion of xanthine to the final product uric acid was measured at an absorbance of 294 nm, and the IC50 value of each Chinese herbal medicine was calculated. Gardenia and Qingguo were selected as the two single herbs with better effects for subsequent prescriptions.

[0071] 2. Conduct in vitro anti-inflammatory experiments, including MTT experiment and Griess reagent method.

[0072] (1) Raw264.7 cells in the logarithmic growth phase were taken and the cell density was adjusted to 2×105 cells / mL. The cells were seeded in a 96-well plate at a density of 2×104 cells / well, with 100 μL per well, and cultured in a constant temperature incubator for 24 h.

[0073] The cells were treated with Chinese herbal medicine extracts of different concentrations, and a blank group and a zero-adjustment group were set up for 16 hours.

[0074] Add 20 μL of MTT solution under light-proof conditions, mix and incubate for 4 h, discard the supernatant, add 150 μL of DMSO to each well, oscillate for 10 min, read the absorbance at 490 nm after the crystals are fully dissolved, and calculate the cell survival rate.

[0075] (2) Raw264.7 cells were inoculated in 96-well plates at 2×104 cells / well and treated with different concentrations of Chinese herbal medicine extracts and MSU for 24 h. A blank group, MSU group, and zero adjustment group were set up. The supernatant was taken and the NO level of each group was detected using the Griess reagent method. Two single herbs with good anti-inflammatory effects were selected: dandelion and honeysuckle for subsequent prescriptions.

[0076] 3. Use Design-Expert 13 software and Box-Behnken experimental design principle to carry out response surface optimization experiment, and design a total of 27 experimental points.

[0077] The experimental scheme is shown in Table 1:

[0078] Table 1 Experimental plan

[0079]

[0080] From the analysis of Table 1, it can be seen that the best ratio of the formula is dandelion: honeysuckle: gardenia: green fruit = 2: 2.809: 2.859: 3.000. In order to facilitate practical operation, the best ratio is set as dandelion: honeysuckle: gardenia: green fruit = 2: 3: 3: 3.

[0081] Effect of the medicinal and edible composite effervescent tablet of the present invention on serum uric acid in mice

[0082] The experimental process is to randomly divide 48 male SD rats, whose body weight usually ranges from 180g to 320g and whose age ranges from 6-8 weeks, into a blank group, a model group, a positive drug group, and high-, medium-, and low-dose groups of Chinese medicinal material extracts; the solution concentrations of the high-, medium-, and low-dose groups of Chinese medicinal material extracts are 25g / L, 50g / L, and 150g / L, respectively.

[0083] Except for the blank group and the model group, the other groups were first gavaged with drugs of different concentrations of 25g / L, 50g / L, and 150g / L, with a maximum gavage volume of 5mL for 7 days. The drugs were administered while modeling on the 7th day. The blank group was fed with ordinary feed, and the other groups were fed with yeast extract feed combined with gavage of potassium oxonate for 14 days to prepare the HUA model; on the 14th day, the outer posterior part of the right ankle joint was used as the puncture site, which was bent and locally disinfected, and the needle was inserted upward at a 45° angle to the tibia (modified), and 50μL of 50mg / L sodium urate solution was injected into the rat joint cavity to prepare the GA model.

[0084] The levels of serum uric acid and inflammatory factor interleukin-1β, ankle joint swelling and ankle joint tissue pathology were evaluated.

[0085] like Figure 1-Figure 3 As shown in the figure, according to the experimental results, both the high-dose and medium-dose groups can reduce the levels of uric acid and inflammatory factors, which are significantly different from the model group (P < 0.01), and the high-dose and medium-dose groups can effectively relieve swelling, which shows that high- and medium-dose administration can effectively prevent and treat gout.

[0086] The above is only an exemplary embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily thought of by a person skilled in the art within the technical scope disclosed by the present invention should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A medicinal and edible composite effervescent tablet for treating gout, characterized in that: The invention is prepared from the following raw materials: 10-30 parts of honeysuckle extract, 10-30 parts of green fruit extract, 10-30 parts of gardenia extract, 10-30 parts of dandelion extract, 3-8 parts of disintegrant, 5-10 parts of sweetener, 1-5 parts of filler, 2-5 parts of wetting agent, 15-30 parts of acid source and 25-40 parts of alkali source.

2. The medicinal and edible composite effervescent tablet for treating gout according to claim 1, characterized in that: The invention is prepared from the following raw materials: 20-30 parts of honeysuckle extract, 20-30 parts of green fruit extract, 20-30 parts of gardenia extract, 10-20 parts of dandelion extract, 3-5 parts of disintegrant, 8-10 parts of sweetener, 2-5 parts of filler, 4-5 parts of wetting agent, 20-30 parts of acid source and 25-30 parts of alkali source.

3. The method for preparing the medicinal and edible composite effervescent tablet for treating gout according to any one of claims 1 to 2, characterized in that: The following steps are involved: (1) preparing honeysuckle extract, green fruit extract, gardenia extract and dandelion extract through an extraction process, and then concentrating the honeysuckle extract, green fruit extract, gardenia extract and dandelion extract through a concentration process, mixing them according to a certain proportion, and preparing a traditional Chinese medicine extract; (2) adding a disintegrant, a sweetener, a filler and a wetting agent to a traditional Chinese medicine extract and preparing a mixture through a drying process; (3) adding an acid source and an alkali source to the mixture, mixing to prepare a soft material, and pressing the mixture into tablets. The composite effervescent tablets of medicine and food for treating gout are prepared through a molding process.

4. The method for preparing the composite effervescent tablets of medicine and food for treating gout according to claim 3, characterized in that: In step (1), the extraction process is determined by a single factor method to determine the solid-liquid ratio, single extraction time and number of extractions; the concentration process is one of atmospheric pressure concentration and reduced pressure concentration.

5. The method for preparing the composite effervescent tablets of medicine and food for treating gout according to claim 3, characterized in that: In step (1), the honeysuckle extract, the green fruit extract, the gardenia extract and the dandelion extract are in a mass ratio of (1-3): (1-3): (1-3): (1-3).

6. The method for preparing the composite effervescent tablets of medicine and food for treating gout according to claim 3, characterized in that: In step (2), the drying process is one of vacuum drying, freeze drying, and normal pressure drying.

7. The method for preparing the composite effervescent tablets for treating gout according to claim 3, characterized in that: In step (3), the molding process determines the amount of extract added, the amount of disintegrant added, the disintegrant ratio and the amount of sweetener added by a single factor method.

8. The method for preparing the composite effervescent tablets of medicine and food for treating gout according to claim 3, characterized in that: The extraction process was carried out according to a solid-liquid ratio of 1:12, with extractions performed twice and a single extraction time of 1.5 h to obtain a medicinal solution, which was concentrated under reduced pressure at 80° C. and vacuum dried to obtain a Chinese medicine extract.

9. The method for preparing the composite effervescent tablets of medicine and food for treating gout according to claim 3, characterized in that: The effervescent tablets are prepared by separate granulation of acid and base, and the specific preparation process is as follows: Crush the sodium bicarbonate and citric acid separately, pass through an 80-mesh sieve for later use; mix the Chinese herbal medicine extract, lactose and sweetener evenly and divide them into two parts, respectively make a soft material with sodium bicarbonate and citric acid using 95% ethanol, dry at 55°C to obtain dry granules, sieve through a 24-mesh sieve and press into tablets.

10. Use of the composite effervescent tablet as claimed in any one of claims 1 to 2 in the preparation of a medicament for treating gout.

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