Catheter pump with oxygenation function

Abstract

The application is a catheter pump with oxygenation function which can directly improve the myocardial hypoxia condition. The motor is connected with the catheter at the proximal end, and the impeller is coaxially connected at the distal end. The outer periphery of the impeller is covered with a blood outflow cage. The distal end of the blood outflow cage is fixed with the proximal end of the blood inflow cage through a sleeve. The distal end of the blood inflow cage is also connected with a pigtail tube. An oxygenation unit is arranged on the blood inflow cage. The oxygenation unit produces oxygen in the left ventricle according to the physiological signals collected by the sensing unit, and releases the oxygen into the blood in the left ventricle. The oxygenation unit enters the left ventricle with the blood inflow cage, directly produces oxygen in situ in the left ventricle, supplies oxygen to the blood in the left ventricle, rapidly improves the myocardial hypoxia condition, and promotes the recovery of the heart. The oxygenation unit is integrated on the catheter pump, and the catheter pump is intervened through the blood vessel together with the oxygenation unit, so that the operation is simple, and the damage to the blood vessel can be reduced. This oxygen supply mode can directly improve the myocardial hypoxia condition, and can also improve the aortic valve regurgitation condition and the oxygen supply condition of the systemic circulation.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a catheter pump with oxygenation function. BACKGROUND

[0002] The catheter pump can be introduced into the heart percutaneously and can be configured to assist or replace the natural heart pump function by circulating or continuous pumping of blood to provide hemodynamic support for cardiogenic shock and acute heart failure. The catheter pump generally includes a motor, the proximal end of the motor is connected to a catheter, and the distal end is connected to an impeller. The motor drives the impeller to rotate, thereby pumping the blood in the heart chamber from the blood flow into the cage to the sleeve, and from the blood flow out of the cage from the proximal end of the sleeve into the aorta, establishing a left ventricular-aortic drainage pathway.

[0003] For some severe coronary atherosclerotic heart disease, patients with multi-vessel coronary artery disease, myocardial severe hypoxia and ischemia may occur. In the prior art, the catheter pump directly pumps the blood in the heart chamber to the ascending aorta, which can assist the heart to pump blood, but cannot directly and quickly improve the myocardial hypoxia state. How to achieve this function is a big problem to be solved in the industry. SUMMARY

[0004] The purpose of the present application is to provide a catheter pump with oxygenation function which can directly improve the myocardial hypoxia condition.

[0005] In order to achieve the above purpose, the technical scheme adopted by the present application is as follows: a catheter pump with oxygenation function, comprising a motor, the proximal end of the motor is connected to a catheter, and the distal end is coaxially connected with an impeller, the outer periphery of the impeller is covered with a blood outflow cage, the distal end of the blood outflow cage is fixed with a blood inflow cage through a sleeve, and the distal end of the blood inflow cage is further connected with a pigtail tube, an oxygenation unit is arranged on the blood inflow cage, and the oxygenation unit generates oxygen according to the physiological signals collected by a sensing unit in the left ventricle and releases the oxygen into the blood in the left ventricle in time and as needed.

[0006] Further, the oxygenation unit includes a microfluidic chip and an enzyme membrane, hydrogen peroxide solution enters the microfluidic channel and is separated into independent hydrogen peroxide molecules, the hydrogen peroxide molecules contact the enzyme membrane and undergo a chemical reaction to generate H2O and O2, and the H2O and O2 escape and enter the blood in the ascending aorta.

[0007] Further, the oxygenation unit includes a microfluidic chip, a first liquid inlet pipe for transporting hydrogen peroxide and a second liquid inlet pipe for transporting catalase are respectively communicated with a first sample port and a second sample port of the microfluidic chip, and the hydrogen peroxide solution undergoes a chemical reaction in the mixing flow channel of the microfluidic chip to generate H2O and O2, and the H2O and O2 escape from the substrate outlet of the microfluidic chip and enter the blood in the ascending aorta.

[0008] Further, the blood inflow cage comprises a circular tube-shaped main body, an inflow port is formed on the peripheral wall of the main body, the microfluidic chip is wrapped on the outer wall of the circular tube near the inflow port, the microfluidic chip is in an arc structure which is matched with the shape of the outer wall of the circular tube, the wall thickness of the corresponding circular tube segment of the microfluidic chip is smaller than that of the two side tube segments, the outer wall of the microfluidic chip is smoothly connected with the outer wall of the two side tube segments, the liquid guide tube is communicated with the liquid inlet of the microfluidic chip, a micro-reaction chamber is connected at the substrate outlet of the microfluidic chip, and the enzyme membrane is arranged in the micro-reaction chamber.

[0009] Further, the blood inflow cage comprises a circular tube-shaped main body, an inflow port is formed on the peripheral wall of the main body, the main body is connected with a water dropper at the distal end, the distal end of the water dropper is a frustum segment, the microfluidic chip is wrapped on the outer wall of the frustum segment, the microfluidic chip is in an arc structure which is matched with the shape of the outer wall of the frustum segment, the wall thickness of the corresponding circular tube segment of the microfluidic chip is smaller than that of the two side tube segments, the outer wall of the microfluidic chip is smoothly connected with the outer wall of the two side tube segments, the liquid guide tube is communicated with the liquid inlet of the microfluidic chip, a micro-reaction chamber is connected at the substrate outlet of the microfluidic chip, and the enzyme membrane is arranged in the micro-reaction chamber.

[0010] Further, the micro-reaction chamber is in a tube shape as a whole, one end of the tube body is communicated with the substrate outlet of the microfluidic chip, the other end is provided with an outlet, the enzyme membrane is arranged in the inner cavity of the tube near the outlet, the enzyme membrane divides the inner cavity of the tube, and the catalase is fixed on the membrane sheet near the outlet side.

[0011] Further, the enzyme membrane is arranged on a plastic sheet, the electrode is penetrated through and adhered to the plastic sheet, the enzyme membrane and the electrode constitute an enzyme-promoted current type sensor, the enzyme-promoted current type sensor collects current signals and feeds back to a control host, and the control host adjusts and controls the delivery amount of hydrogen peroxide liquid of the microfluidic chip in real time.

[0012] Further, the sleeve comprises a spring tube and inner and outer membranes which are arranged on the inner and outer sides of the spring tube, the spring tube is formed by winding a shape memory wire, a channel is arranged between the spring tube and the outer membrane, and the liquid guide tube is penetrated through the channel.

[0013] Further, a plane is arranged on the outer wall of the blood inflow cage along the axial direction, the micro-reaction chamber is fixed on the plane, a protective cover is arranged outside the micro-reaction chamber, the outer wall of the protective cover is formed into an arc-shaped flow guide surface which extends from the distal end to the proximal end, and the two ends of the protective cover are also fixed on the plane.

[0014] Further, a groove is formed on the motor shell, the liquid guide tube is penetrated through the groove and enters the guide tube from the tail of the motor, epoxy resin glue is filled in the groove, and a flushing tube, a cable, a reinforced steel cable and an optical fiber are arranged in the guide tube.

[0015] In the above scheme, the oxygenation unit is installed on the blood inflow cage, meaning it enters the left ventricle along with the blood and directly produces oxygen in situ within the left ventricle, supplying oxygen to the blood and thus rapidly improving myocardial hypoxia and promoting cardiac recovery. The oxygenation unit is integrated into the catheter pump, allowing for vascular intervention along with the pump, simplifying operation and minimizing damage to blood vessels. Simultaneously, the oxygenation unit provides in-situ and on-demand oxygenation within the left ventricle; that is, it produces only the amount of oxygen needed in the blood. This oxygen supply method directly improves myocardial hypoxia and also improves aortic valve regurgitation and systemic oxygen supply. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of the duct pump in Example 1;

[0017] Figure 2 for Figure 1 A schematic diagram of the structure after removing the duct and pig tail tube;

[0018] Figure 3 This is a schematic diagram of the blood inflow cage and oxygenation unit in Example 1;

[0019] Figure 4 This is a schematic diagram of the structure of the blood flowing into the cage in Example 1;

[0020] Figure 5 This is a planar unfolded schematic diagram of the oxygenation unit in Example 1;

[0021] Figure 6 for Figure 5 Enlarged diagram of the middle section;

[0022] Figure 7 This is a schematic diagram of the structure of a microfluidic chip;

[0023] Figure 8 This is a schematic diagram of the overall structure of the duct pump in Example 2;

[0024] Figure 9 for Figure 8 A schematic diagram of the structure after removing the duct and pig tail tube;

[0025] Figure 10 This is a schematic diagram of the blood inflow cage and oxygenation unit in Example 2;

[0026] Figure 11 This is a schematic diagram of the structure of the blood flowing into the cage in Example 2;

[0027] Figure 12 This is a planar unfolded schematic diagram of the oxygenation unit in Example 2;

[0028] Figure 13 This is a cross-sectional view of the casing;

[0029] Figure 14 For Figure 13 A-A direction section view in the middle;

[0030] Figure 15 For Figure 1 B-B direction section view in the middle;

[0031] Figure 16 It is the plane development schematic diagram of micro-fluidic chip in example 3;

[0032] Figure 17 It is the schematic diagram of use state of catheter pump. DETAILED DESCRIPTION

[0033] In order to facilitate understanding, first, we define the orientation: "proximal", "proximal side" refers to the side close to the operator / doctor, "distal", "distal side" refers to the side away from the operator / doctor, i.e. the side close to the heart, and the following will be combined with Figures 1-17 The application is further described in detail.

[0034] A catheter pump with oxygenation function, comprising a motor 10, the proximal end of the motor 10 is connected with a catheter 20, the distal end is coaxially connected with an impeller, the outer periphery of the impeller is covered with a blood outflow cage 30, the distal end of the blood outflow cage 30 is fixed with the proximal end of a blood inflow cage 50 through a sleeve 40, and the distal end of the blood inflow cage 50 is further connected with a pigtail 60, an oxygenation unit 70 is arranged on the blood inflow cage 50, and the oxygenation unit 70 performs oxygen production in the left ventricle according to physiological signals collected by a sensing unit and releases oxygen into the blood in the left ventricle.

[0035] In the above scheme, the catheter pump is inserted into the ventricle through the blood vessel, at this time, the pigtail 60, the blood inflow cage 50 and part of the sleeve 40 are located in the left ventricle, the sleeve 40 crosses the aortic valve, part of the sleeve, the blood outflow cage 30 and the motor 10 are located in the ascending aorta, the motor 10 drives the impeller to rotate and then pumps the blood in the left ventricle into the aorta, and then participates in the systemic circulation. The oxygenation unit 70 is arranged on the blood inflow cage 50, that is, the oxygenation unit enters the left ventricle along with the blood inflow cage 50, directly produces oxygen in situ in the left ventricle, and supplies oxygen to the blood in the left ventricle, so as to quickly improve the hypoxic condition of myocardium and promote the recovery of heart. The oxygenation unit 70 is integrated on the catheter pump and is inserted into the blood vessel together with the catheter pump, so that the operation is simple and the damage to the blood vessel can be reduced. At the same time, the oxygenation unit 70 produces oxygen in the left ventricle according to time and demand, that is, how much oxygen is needed in the blood and when the oxygen is needed, we produce how much oxygen in situ in the left ventricle at the time when the oxygen is needed.

[0036] Another key point in the application is to directly supplement oxygen into the left ventricle, and this arrangement has the following beneficial effects:

[0037] 1. Directly improve the oxygen deficiency of myocardium: When oxygen is directly supplemented into the left ventricle, it can be taken by myocardium more quickly, thus improving the oxygen deficiency of myocardium and promoting the recovery of myocardial function.

[0038] 2. Improve the regurgitation of aortic valve: The supplement of oxygen into the ventricle can change the blood composition and pressure distribution in the ventricular cavity, thus improving the regurgitation of aortic valve; meanwhile, by precisely controlling the generation amount of oxygen, the blood dynamics inside the heart can not be affected.

[0039] 3. Improve the oxygen supply of systemic circulation: The blood supplemented into the ventricle is pumped into ascending aorta by the heart / catheter pump, and then reaches the systemic circulation, thus having a certain improvement on the oxygen supply of systemic circulation.

[0040] In order to realize the on-demand oxygen generation, it is expected that the hydrogen peroxide and catalase can only have a trace chemical reaction at a time to generate a trace amount of O2, preferably one molecule at a time. In order to achieve the above purpose, the oxygenation unit 70 comprises a microfluidic chip 71 and an enzyme membrane 72, the hydrogen peroxide solution enters the microfluidic channel from the liquid guide pipe 73 and is separated into independent hydrogen peroxide molecules, the hydrogen peroxide molecules contact the enzyme membrane 72 and have a chemical reaction to generate H2O and O2, and the H2O and O2 escape and enter the blood in the left ventricle. Here, the hydrogen peroxide and catalase are used to generate oxygen through chemical reaction, and the reaction products are H2O and O2, wherein O2 is mixed into the blood in the left ventricle to supplement oxygen to the blood, and H2O is also needed in the human body, thus not causing any harm to the human body.

[0041] The membrane is a good carrier for enzyme immobilization. Compared with ordinary chemical reactions, the hydrogen peroxide enzyme reaction rate is fast, and in the catalytic process of H2O2, the higher the concentration of catalase, the faster the catalysis of H2O2, so we immobilize catalase on the membrane to ensure the high concentration of catalase. The microfluidic chip 71 is made of a flexible material such as polydimethylsiloxane (PDMS), which is provided with a microfluidic channel with a size of microns or even nanometers, which can accurately control the reaction amount. The technology of separating hydrogen peroxide solution into microdroplets by microfluidic chip 71 is a known technology, which will not be described in detail here. The hydrogen peroxide solution is separated into microdroplets or even hydrogen peroxide molecules in an interval arrangement after passing through the microfluidic channel, and then the hydrogen peroxide molecules react quickly with the enzyme to obtain O2 for blood oxygen supply when passing through the enzyme membrane 72.

[0042] In order to achieve the above-mentioned purpose, the microfluidic chip 71 is used to control the amount of hydrogen peroxide. The microfluidic chip 71 can precisely control the fluid by the microfluidic channel and other functional components. The microfluidic channel is used to realize the micro delivery of the fluid and achieve the purpose of in-situ oxygen production. The concentration of the catalase on the enzyme membrane 72 is large. When the hydrogen peroxide molecules contact the enzyme membrane 72, the chemical reaction occurs immediately, thereby achieving the purpose of timely oxygen supply. The transmission, mixing and separation of the micro liquid drops in the channel can be accurately realized by the computer programming control, thereby realizing the quantitative oxygen production.

[0043] As to the specific position of the oxygenation unit 70 on the blood inflow cage 50, the present application provides two specific schemes.

[0044] Embodiment 1

[0045] Referring to Figures 1-7 As shown in the figure, the blood inflow cage 50 includes a circular tube-shaped main body 51. The peripheral wall of the main body 51 is provided with a blood inlet 52. The microfluidic chip 71 is wrapped around the proximal circular tube of the blood inlet 12. The microfluidic chip 71 is an arc-shaped structure which is matched with the shape of the outer wall of the circular tube. The wall thickness of the corresponding circular tube segment of the microfluidic chip 71 is smaller than that of the two side tube segments. The outer wall of the microfluidic chip 71 is smoothly connected with the outer wall of the two side tube segments. The liquid guide tube 73 is communicated with the liquid inlet of the microfluidic chip 71. The substrate outlet of the microfluidic chip 71 is connected with a micro-reaction chamber 74. The enzyme membrane 72 is arranged in the micro-reaction chamber 74. The microfluidic chip 71 is made of a substrate with soft characteristics, such as PMDS, to adapt to the circular tube shape of the surface of the main body 51. On the one hand, the outer diameter of the catheter pump is reduced. On the other hand, the contact area between the microfluidic chip 71 and the surface of the main body 51 is increased, thereby improving the reliability of the connection. The two can be fixed by gluing. The wall thickness of the corresponding circular tube segment of the microfluidic chip 71 is smaller than that of the two side tube segments, that is, there is an annular groove on the tube wall for installing the microfluidic chip 71. The outer wall of the microfluidic chip 71 is smoothly connected with the outer wall of the two side tube segments. The outer diameters are similar or equal from the outside, thereby reducing the damage to the blood vessel during the intervention and withdrawal of the catheter pump.

[0046] In this embodiment, the microfluidic chip 71 is wrapped around the outer wall of the circular tube. Therefore, its shape is regular, which is convenient for manufacturing, and the wiring mode of the liquid guide tube 73 is relatively simple. However, the blood inlet 52 and the microfluidic chip 71 need to be arranged on the circular tube segment. Therefore, the axial length of the circular tube segment needs to be lengthened.

[0047] Embodiment 2

[0048] Referring to Figures 8-12As shown, the blood inflow cage 50 includes a cylindrical main body 51 with a blood inlet 52 on its peripheral wall. A water droplet 53 is connected to the distal end of the main body 51, and the distal end of the water droplet 53 is a conical segment 54. The microfluidic chip 71 is wrapped around the outer wall of the conical segment 54, and the microfluidic chip 71 is an arc-shaped structure that fits the shape of the outer wall of the conical segment 54. The wall thickness of the cylindrical segment corresponding to the microfluidic chip 71 is smaller than the wall thickness of the two side segments. The outer wall of the microfluidic chip 71 is smoothly connected to the outer walls of the two side segments. The liquid guide tube 73 is connected to the liquid inlet of the microfluidic chip 71. A microreaction chamber 74 is connected to the substrate outlet of the microfluidic chip 71, and an enzyme membrane 72 is disposed in the microreaction chamber 74.

[0049] In this embodiment, the microfluidic chip 71 is disposed on the conical segment 54, so the shape of the microfluidic chip 71 must also be curled into a conical shape (not a complete conical shape, but with an opening). The manufacturing process is slightly more complex than in embodiment 1. The fluid guide tube 73 must also extend a certain distance from the outer wall of the blood inflow cage 50 towards the proximal end. Since the outer diameter of the conical segment 54 is smaller than the outer diameter of the entire catheter pump, it is even possible to not do any treatment on the wall thickness of the circular tube segment (reduce the wall thickness). Therefore, the microfluidic chip 71 wrapped around the conical segment 54 will not increase the outer diameter of the entire catheter pump, resulting in less damage to blood vessels and cardiac tissue during intervention. Even if the wall thickness of the circular tube segment corresponding to the microfluidic chip 71 is set to be smaller than the wall thickness of the tube segments on both sides, since the thickness of the conical segment 54 is relatively thick, the wall thickness treatment will not have any impact on the strength of the conical segment 54.

[0050] Furthermore, such as Figure 6 As shown, the microreaction chamber 74 is tubular in shape, i.e., a micro-channel reaction chamber. It is small in size, with one end connected to the substrate outlet of the microfluidic chip 71, and the other end having an outlet 741. An enzyme membrane 72 is disposed within the tubular cavity near the outlet, dividing the cavity. Catalase is fixed to a membrane near the outlet 741. This means that hydrogen peroxide can only react with the enzyme when it passes through the membrane to the other side. The generated H2O and O2 do not need to pass through the membrane again, thus allowing them to enter the bloodstream more rapidly and bind to the hypoxic hemoglobin in the left ventricle at that moment, achieving timely and on-demand oxygen supply. A one-way valve / membrane structure can also be provided at the outlet 741 to allow only H2O and O2 to escape while preventing blood from entering the microreaction chamber 74. Alternatively, the enzyme membrane 72 can be made of a material that allows hydrogen peroxide to pass easily but prevents blood, H2O, and O2 from passing through.

[0051] The enzyme membrane 72 is placed on a plastic sheet (shown in the figure), and the electrode (shown in the figure) is passed through and adhered to the plastic sheet, and the enzyme membrane 72 and the electrode constitute an enzymatic current type sensor, which collects a current signal and feeds back to a control host, which adjusts and controls the delivery amount of hydrogen peroxide solution of the microfluidic chip 71 in real time. At the same time, the enzymatic current type sensor can also detect the concentration of O2 generated by the chemical reaction, and the generation of O2 is detected in real time. The effluent hydrogen peroxide and the hydrogen peroxidase attached to the membrane undergo dismutation reaction:

[0052] 2H2O2(CAT enzyme) = 2H2O + O2↑

[0053] In this way, two H2O2 molecules meet and collide on the active center of CAT in turn, and a dismutation reaction occurs to generate two H2O molecules and one O2 molecule.

[0054] Since the microfluidic chip 71 is arranged on the blood inflow cage 50, and the liquid guide pipe 73 needs to be led out to the proximal end and connected to the liquid storage tank, how to lead out the liquid guide pipe 73 is a problem that needs to be considered. The sleeve pipe 40 includes a spring pipe 41 and an inner membrane 42 and an outer membrane 43 arranged on the inner and outer sides of the spring pipe 41, the spring pipe 41 is made of shape memory wire (such as nickel-titanium alloy wire) winding, a channel 44 is arranged between the spring pipe 41 and the outer membrane 43, and the liquid guide pipe 73 passes through the channel 44. In this way, the liquid guide pipe 73 passes through the inner wall of the sleeve pipe 40, on the one hand, to ensure the smoothness of the inner and outer walls of the sleeve pipe 40, and on the other hand, the position of the liquid guide pipe 73 is relatively fixed, preventing it from being twisted and hindering the delivery of hydrogen peroxide solution, and the liquid guide pipe 73 is protected in the channel 44, preventing the blood flow from affecting the delivery of hydrogen peroxide solution, and ensuring the quantitative and stable delivery of hydrogen peroxide solution.

[0055] During the process of vascular intervention, the tortuous path and / or calcified anatomical structure can hinder and damage the micro-reaction chamber 74, so a plane (not shown in the figure) is arranged on the outer wall of the blood inflow cage 50 along the axial direction, and the micro-reaction chamber 74 is fixed on the plane to enhance the reliability of the connection. At the same time, the outer part of the micro-reaction chamber 74 is provided with a protective cover 75, and the outer wall of the protective cover 75 is configured as an arc-shaped flow guide surface extending from the distal end to the proximal end, and the two ends of the protective cover 75 are also fixed on the plane, and the connection is firm and reliable. The protective cover 75 can prevent blood from directly washing the micro-reaction chamber 74, and can also reduce the damage to blood vessels and other tissues during the intervention process.

[0056] Example 3

[0057] As Figure 16As shown, the oxygenation unit 70 includes a microfluidic chip 71, a first liquid inlet pipe for delivering hydrogen peroxide and a second liquid inlet pipe for delivering catalase are communicated with a first sample port and a second sample port of the microfluidic chip 71 respectively, the hydrogen peroxide solution reacts in the mixing flow channel of the microfluidic chip 71 to generate H2O and O2, the H2O and O2 escape from the substrate outlet of the microfluidic chip 71 and enter the blood in the left ventricle. In this embodiment, two liquid inlet pipes are arranged to deliver hydrogen peroxide and catalase respectively, so that no enzyme membrane structure needs to be arranged, and even the micro-reaction chamber 74 can be arranged on the microfluidic chip 71 without additional arrangement. We control the amount of hydrogen peroxide and catalase by using the microfluidic chip 71, the microfluidic chip 71 can realize precise control of fluid through microchannels, reaction chambers and other functional components, and can accurately realize the transmission, mixing and separation of microdroplets in the channel, so as to realize quantitative oxygen production. Compared with embodiments 1 and 2, this embodiment can omit the enzyme membrane unit and the additional micro-reaction chamber structure, so that the volume is reduced. However, the design inside the microfluidic chip is relatively complex, and two liquid inlet pipes are needed, and the design of the liquid inlet pipe is also more complex.

[0058] The guide tube 73 is arranged to pass through the groove and enter the catheter 20 from the tail of the motor 10, and the groove is filled with epoxy resin glue. The guide tube 73 is clamped in the groove and fixed by the epoxy resin glue, and the groove is filled, so as to ensure the flatness and smoothness of the surface of the motor 10 shell, and further reduce the damage to blood vessels or other tissues during intervention. The catheter 20 is also provided with a flushing pipe 21, a cable 22, a reinforcing steel cable 23 and an optical fiber 24, wherein the optical fiber 24 is used to transmit light signals, the guide tube 73 is used to deliver hydrogen peroxide solution, the flushing pipe 21 is used to deliver backwash liquid to prevent blood from entering the motor 10 to form thrombus, the cable 22 is used to power the motor 10, and the reinforcing steel cable 23 is used to enhance the stiffness of the catheter 20 so that it can push the pumping assembly into the designated position.

[0059] The above structure can also be applied to right ventricular catheter pumps, foldable blood pumps and IABP devices for supplementing oxygen to the human body.

[0060] Of course, the present application is not limited to the details of the above-described exemplary embodiments but encompasses many alternatives, modifications and equivalents without departing from the spirit or essential characteristics of the application. Thus, the embodiments are to be regarded as illustrative in nature and non-limiting, the scope of the application being defined by the appended claims rather than by the foregoing description, and all changes that come within the meaning and range of equivalents of the claims are to be embraced. No feature of the application is to be construed as limiting the scope of the claims to its exact counterpart.

[0061] Furthermore, it should be understood that although the description is made on the basis of the embodiments, not every embodiment contains only one independent technical solution, and the description of the specification is only for the sake of clarity, and those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that those skilled in the art can understand.

Claims

1. A duct pump with oxygenation function, comprising a motor (10), the proximal end of the motor (10) being connected to a duct (20), and the distal end being coaxially connected to an impeller, the outer periphery of the impeller being provided with a blood outflow cage (30), the distal end of the blood outflow cage (30) being fixed to the proximal end of a blood inflow cage (50) via a sleeve (40), and the distal end of the blood inflow cage (50) being further connected to a pig tail tube (60), characterized in that: The blood inflow cage (50) is equipped with an oxygenation unit (70). The oxygenation unit (70) generates oxygen in the left ventricle on time and as needed according to the physiological signals collected by the sensor unit and releases oxygen into the blood in the left ventricle. The oxygenation unit (70) includes a microfluidic chip (71) and an enzyme membrane (72). Hydrogen peroxide solution enters the microchannel from the liquid guide tube (73) and is separated into independent hydrogen peroxide molecules. The hydrogen peroxide molecules come into contact with the enzyme membrane (72) and undergo a chemical reaction to generate H2O and O2. H2O and O2 escape and enter the blood of the ascending aorta. The blood inflow cage (50) includes a cylindrical main body (51), and a blood inlet (52) is provided on the peripheral wall of the main body (51). The microfluidic chip (71) is wrapped around the tube body of the cylindrical tube near the blood inlet (52). The microfluidic chip (71) is an arc-shaped structure that fits the shape of the outer wall of the cylindrical tube. The wall thickness of the cylindrical tube segment corresponding to the microfluidic chip (71) is smaller than the wall thickness of the tube segments on both sides. The outer wall of the microfluidic chip (71) is smoothly connected to the outer wall of the tube segments on both sides. The liquid guide tube (73) is connected to the liquid inlet of the microfluidic chip (71). A micro-reaction chamber (74) is connected to the substrate outlet of the microfluidic chip (71). The enzyme membrane (72) is placed in the micro-reaction chamber (74). A plane is provided on the outer wall of the blood inflow cage (50) along its axial direction. The micro-reaction chamber (74) is fixed on the plane. The outer cover of the micro-reaction chamber (74) is provided with a protective cover (75). The outer wall of the protective cover (75) is constructed as an arc-shaped guide surface extending from the distal end to the proximal end. Both ends of the protective cover (75) are also fixed on the plane.

2. A duct pump with oxygenation function, comprising a motor (10), the proximal end of the motor (10) being connected to a duct (20), and the distal end being coaxially connected to an impeller, the outer periphery of the impeller being provided with a blood outflow cage (30), the distal end of the blood outflow cage (30) being fixed to the proximal end of a blood inflow cage (50) through a sleeve (40), and the distal end of the blood inflow cage (50) being further connected to a pig tail tube (60), characterized in that: The blood inflow cage (50) is equipped with an oxygenation unit (70). The oxygenation unit (70) generates oxygen in the left ventricle on time and as needed according to the physiological signals collected by the sensor unit and releases oxygen into the blood in the left ventricle. The oxygenation unit (70) includes a microfluidic chip (71) and an enzyme membrane (72). Hydrogen peroxide solution enters the microchannel from the liquid guide tube (73) and is separated into independent hydrogen peroxide molecules. The hydrogen peroxide molecules come into contact with the enzyme membrane (72) and undergo a chemical reaction to generate H2O and O2. H2O and O2 escape and enter the blood of the ascending aorta. The blood inflow cage (50) includes a cylindrical main body (51), with a blood inlet (52) on the peripheral wall of the main body (51). A water droplet (53) is connected to the distal end of the main body (51), and the distal end of the water droplet (53) is a conical segment (54). The microfluidic chip (71) is wrapped around the outer wall of the conical segment (54), and the microfluidic chip (71) is an arc-shaped structure that fits the shape of the outer wall of the conical segment (54). The wall thickness of the cylindrical segment corresponding to the microfluidic chip (71) is smaller than the wall thickness of the two side segments. The outer wall of the microfluidic chip (71) is smoothly connected to the outer wall of the two side segments. The liquid guide tube (73) is connected to the liquid inlet of the microfluidic chip (71). A micro-reaction chamber (74) is connected to the substrate outlet of the microfluidic chip (71), and the enzyme membrane (72) is placed inside the micro-reaction chamber (74). A plane is provided on the outer wall of the blood inflow cage (50) along its axial direction. The micro-reaction chamber (74) is fixed on the plane. The outer cover of the micro-reaction chamber (74) is provided with a protective cover (75). The outer wall of the protective cover (75) is constructed as an arc-shaped guide surface extending from the distal end to the proximal end. Both ends of the protective cover (75) are also fixed on the plane.

3. A duct pump with oxygenation function according to claim 1 or 2, characterized in that: The oxygenation unit (70) includes a microfluidic chip (71), a first inlet tube for delivering hydrogen peroxide and a second inlet tube for delivering catalase are respectively connected to the first sample port and the second sample port of the microfluidic chip (71). The hydrogen peroxide solution undergoes a chemical reaction in the mixing channel of the microfluidic chip (71) to generate H2O and O2. H2O and O2 escape from the substrate outlet of the microfluidic chip (71) and enter the blood of the ascending aorta.

4. A duct pump with oxygenation function according to claim 1 or 2, characterized in that: The microreaction chamber (74) is tubular in shape. One end of the tube is connected to the substrate outlet of the microfluidic chip (71), and the other end is provided with an outlet (741). An enzyme membrane (72) is placed in the inner cavity of the tube near the outlet, and the enzyme membrane (72) divides the inner cavity of the tube. Catalase is fixed on a membrane on the side near the outlet (741). The enzyme membrane (72) is placed on a plastic sheet. The electrode passes through and is bonded to the plastic sheet. The enzyme membrane (72) and the electrode constitute an enzyme-catalyzed current sensor. The enzyme-catalyzed current sensor collects the current signal and feeds it back to the control host. The control host adjusts and controls the delivery amount of hydrogen peroxide liquid of the microfluidic chip (71) in real time.

5. A duct pump with oxygenation function according to claim 1 or 2, characterized in that: The sleeve (40) includes a spring tube (41) and an inner membrane (42) and an outer membrane (43) covering the inner and outer sides of the spring tube (41). The spring tube (41) is made of shape memory wire wound together. A channel (44) is sandwiched between the spring tube (41) and the outer membrane (43). The liquid guide tube (73) passes through the channel (44).

6. A catheter pump with oxygenation function according to claim 1 or 2, characterized in that: The motor (10) housing has a groove, and the liquid guide tube (73) passes through the groove and enters the conduit (20) from the tail of the motor (10). The groove is filled with epoxy resin. The conduit (20) is also equipped with a flushing tube (21), a cable (22), a reinforcing steel cable (23), and an optical fiber (24).

Images