Composition with hangover alleviating effect and preparation process

Abstract

The composition comprises main components and auxiliary materials, the main components comprise the following components in parts by weight: 50-90 parts of radix puerariae powder, 30-50 parts of radix puerariae powder, 30-50 parts of hovenia dulcis thunb powder, 20-40 parts of pomegranate bark powder, 20-40 parts of rosemary powder, 20-40 parts of piper longum powder and 0.5-1.0 part of epigallocatechin gallate; the auxiliary materials comprise the following components in parts by weight: 0-10 parts of propylene glycol, 0-5 parts of glycerol, 0-0.3 part of cyclodextrin and 0-0.2 part of xanthan gum. The ADH activity can be obviously improved, and the antioxidation property is relatively strong, so that a good hangover alleviating effect is realized. Meanwhile, the composition disclosed by the invention is good in stability, safe and non-toxic, overcomes the defects of an existing anti-alcohol product in the aspects of enzyme activation capability, oxidation resistance, stability, safety and the like, and has important market value and application prospect.

Description

Technical Field

[0001] The invention relates to the technical field of food, and in particular to a composition with alcohol sobering effect and a preparation process thereof. Background Art

[0002] Excessive drinking can lead to alcohol poisoning, which is seriously harmful to human health. The metabolism of alcohol in the body mainly depends on alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH). The activity of these two enzymes directly affects the metabolic rate of alcohol. ADH oxidizes ethanol into acetaldehyde, while ALDH further oxidizes acetaldehyde into acetic acid, which is eventually decomposed into carbon dioxide and water and excreted from the body. When drinking excessively, the activity of ADH and ALDH is not enough to metabolize alcohol quickly, resulting in the accumulation of acetaldehyde in the body, causing symptoms of drunkenness such as headache, nausea, and vomiting, and even alcohol poisoning, liver damage, etc. in severe cases. Excessive drinking can lead to alcohol poisoning, which is seriously harmful to human health. The metabolism of alcohol in the body mainly depends on alcohol dehydrogenase and acetaldehyde dehydrogenase.

[0003] At present, there are some hangover products on the market, which can be divided into the following categories: (1) Chemical synthetic drugs: such as naloxone, metadoxine, etc., which mainly work by inhibiting alcohol absorption or accelerating alcohol metabolism. However, these drugs often have problems such as large side effects and uncertain efficacy. (2) Plant extracts: such as kudzu root, kudzu flower, and Hovenia dulcis, which have certain hangover effects, but the mechanism of action is not yet clear, and the effect of a single ingredient is limited. In addition, the addition of Chinese herbal extracts can easily make the system unstable, and precipitation is easy to occur when stored for a long time. (3) Functional foods: such as yogurt, honey, etc., which mainly relieve the symptoms of drunkenness by providing energy and protecting the gastric mucosa, but the hangover effect is limited. In recent years, as people pay more attention to health and quality of life, the development of safe and effective hangover products with clear mechanisms of action has become a research hotspot.

[0004] Studies have shown that increasing ADH activity is the key to sobering up. In addition, the synergistic effect of multiple ingredients can achieve a better sobering up effect. However, existing products are difficult to balance between sobering up effect and low side effects, which is not enough to meet market demand.

[0005] In view of the above problems, the present invention provides a composition with alcohol sobering effect and a preparation process. Summary of the invention

[0006] The present invention provides a composition with hangover-relieving effect and a preparation process thereof. Existing products have a technical problem that it is difficult to strike a balance between the hangover-relieving effect and the low side effects of the product, and are insufficient to meet market demand.

[0007] According to one aspect of the present disclosure, a composition having a hangover-relieving effect is provided, comprising a main component and auxiliary materials: The main components include, by weight: 50-90 parts of kudzu root powder, 30-50 parts of kudzu flower powder, 30-50 parts of Hovenia dulcis powder, 20-40 parts of pomegranate peel powder, 20-40 parts of rosemary powder, 20-40 parts of Piper longifolia powder, and 0.5-1.0 parts of epigallocatechin gallate; The auxiliary materials include: 0-10 parts of propylene glycol, 0-5 parts of glycerol, 0-0.3 parts of cyclodextrin, and 0-0.2 parts of xanthan gum.

[0008] A preparation process of a composition having a hangover-relieving effect, the preparation process is used to prepare the composition, and the preparation process comprises the following steps: S1: Weigh various plant components in a set proportion, mix the weighed plant components evenly, extract them using an oil-water mixed solvent, and filter to obtain an extract; S2: Heat the extract obtained in S1 to 45-65°C, add a stabilizer, let stand for 30 minutes to allow the components to fully swell, and then stir evenly; S3: epigallocatechin gallate is added to 95 parts of pure water in sequence, and stirred to obtain a clear aqueous solution; S4: adding the aqueous solution obtained in S3 to the solution obtained in S2 three times, stirring for 5 minutes each time, and obtaining a composition having a hangover sobering effect after the stirring is completed.

[0009] In a possible implementation, in step S1, the oil-water mixed solvent is a propylene glycol-water mixed solvent, and the ratio of propylene glycol to water is one of 10:0, 7:3, 5:5, 3:7, and 0:10.

[0010] In a possible implementation, in step S1, the extraction method is ultrasonic extraction, the extraction temperature is 0-75°C, and the extraction time is 0-60 minutes.

[0011] In a possible implementation, in step S2, the stabilizer is one or more of propylene glycol, glycerol, cyclodextrin, and xanthan gum.

[0012] Compared with the prior art, the present invention has the following beneficial effects: Synergistic effect: The kudzu root, kudzu flower and Hovenia dulcis in the composition of the present invention all have the effect of activating the activity of alcohol dehydrogenase, and the addition of pomegranate peel powder, rosemary powder, Piper longum powder and epigallocatechin gallate further enhances the activity of alcohol dehydrogenase.

[0013] Optimization of extraction process: A dual extraction process of alcohol precipitation and oil-water mixing was adopted, and food-grade propylene glycol and purified water were used to extract Chinese herbal medicines to obtain Chinese herbal medicine extracts with good stability and strong alcohol dehydrogenase activation ability.

[0014] Active ingredient retention: Through ultrasonic extraction process, the extraction temperature and time are controlled to maximize the extraction and retention of active ingredients, significantly improving the activation effect of the composition on alcohol dehydrogenase.

[0015] Excellent stability: Cyclodextrin, xanthan gum and glycerin are used as stabilizers to ensure that the product remains clear and free of precipitation after long-term storage.

[0016] The present invention discloses a composition with a hangover-relieving effect and a preparation process. The composition can significantly improve the ADH activity by optimizing the formula and production process, and has strong antioxidant properties, thereby achieving a good hangover-relieving effect. At the same time, the composition of the present invention has good stability, safety and non-toxicity, solves the deficiencies of existing hangover-relieving products in terms of enzyme activation ability, antioxidant properties, stability and safety, and has important market value and application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A flowchart of a preparation process of a composition having a hangover-relieving effect according to an embodiment of the present disclosure is shown.

[0018] Figure 2 A physical diagram showing the experimental results of an embodiment of the present disclosure. DETAILED DESCRIPTION

[0019] Various exemplary embodiments, features and aspects of the present disclosure will be described in detail below with reference to the accompanying drawings. The same reference numerals in the accompanying drawings represent elements with the same or similar functions. Although various aspects of the embodiments are shown in the accompanying drawings, the drawings are not necessarily drawn to scale unless otherwise specified.

[0020] The word “exemplary” is used exclusively herein to mean “serving as an example, example, or illustration.” Any embodiment described herein as “exemplary” is not necessarily to be construed as preferred or advantageous over other embodiments.

[0021] In addition, in order to better illustrate the present disclosure, numerous specific details are given in the following specific embodiments. It should be understood by those skilled in the art that the present disclosure can also be implemented without certain specific details. In some examples, methods, means, components and circuits well known to those skilled in the art are not described in detail in order to highlight the subject matter of the present disclosure.

[0022] Example 1: (1) Preparation of raw materials: weigh 50 parts of kudzu root powder, 30 parts of kudzu flower powder, 30 parts of Hovenia dulcis powder, 20 parts of pomegranate peel powder, 20 parts of rosemary powder, and 20 parts of Piper longum powder, and mix them evenly.

[0023] (2) Extraction steps: Use 150 parts of 55% food-grade ethanol for extraction, stir while heating, the stirring temperature is 60°C, the stirring time is 30 minutes, filter after extraction, dry the filtrate at 50°C until the remaining volume is only about 10 mL, add 20 mL of a mixed solvent of propylene glycol and water (mass ratio 7:3) for ultrasonic extraction, the extraction temperature is 50°C, the extraction time is 30 minutes, and filter to obtain the extract.

[0024] (3) Preparation of stabilizer: Heat the extract to 50°C, add 5 parts of glycerol, stir evenly, then add 0.3 parts of cyclodextrin and 0.05 parts of xanthan gum in sequence, let stand for 30 minutes until the components are swollen, and stir evenly.

[0025] (4) Mixing: Add 0.5 parts of epigallocatechin gallate to 95 parts of pure water, stir evenly to obtain a clear aqueous solution.

[0026] The aqueous solution is added to the solution obtained in step 3 three times, and stirred for 5 minutes each time. After the stirring is completed, a composition with alcohol sobering effect is obtained.

[0027] Example 2: (1) Preparation of raw materials: weigh 70 parts of kudzu root powder, 40 parts of kudzu flower powder, 40 parts of Hovenia dulcis powder, 30 parts of pomegranate peel powder, 30 parts of rosemary powder, and 30 parts of Piper longum powder, and mix them evenly.

[0028] (2) Extraction steps: Use 150 parts of 55% food-grade ethanol for extraction, stir while heating, the stirring temperature is 60°C, the stirring time is 30 minutes, filter after extraction, dry the filtrate at 50°C until the remaining volume is only about 10 mL, add 20 mL of a mixed solvent of propylene glycol and water (mass ratio 7:3) for ultrasonic extraction, the extraction temperature is 50°C, the extraction time is 40 minutes, and filter to obtain the extract.

[0029] (3) Preparation of stabilizer: Heat the extract to 50°C, add 5 parts of glycerol, stir evenly, then add 0.3 parts of cyclodextrin and 0.1 parts of xanthan gum in sequence, let stand for 30 minutes until the components are swollen, and stir evenly.

[0030] (4) Mixing: Add 0.7 parts of epigallocatechin gallate to 95 parts of pure water, stir evenly to obtain a clear aqueous solution.

[0031] The aqueous solution is added to the solution obtained in step 3 three times, and stirred for 5 minutes each time. After the stirring is completed, a composition with alcohol sobering effect is obtained.

[0032] Example 3: (1) Preparation of raw materials: weigh 90 parts of kudzu root powder, 50 parts of kudzu flower powder, 50 parts of Hovenia dulcis powder, 40 parts of pomegranate peel powder, 40 parts of rosemary powder, and 40 parts of Piper longum powder, and mix them evenly.

[0033] (2) Extraction steps: Use 150 parts of 55% food-grade ethanol for extraction, stir while heating, the stirring temperature is 60°C, the stirring time is 30 minutes, filter after extraction, dry the filtrate at 50°C until the volume is only about 10 mL, add 20 mL of a mixed solvent of propylene glycol and water (mass ratio 7:3) for ultrasonic extraction, the extraction temperature is 50°C, the extraction time is 50 minutes, and filter to obtain the extract.

[0034] (3) Preparation of stabilizer: Heat the extract to 50°C, add 5 parts of glycerol, stir evenly, then add 0.3 parts of cyclodextrin and 0.2 parts of xanthan gum in sequence, let stand for 30 minutes until the components are swollen, and stir evenly.

[0035] (4) Mixing: Add 1 part of epigallocatechin gallate to 95 parts of pure water, stir evenly to obtain a clear aqueous solution.

[0036] The aqueous solution is added to the solution obtained in step 3 three times, and stirred for 5 minutes each time. After the stirring is completed, a composition with alcohol sobering effect is obtained.

[0037] Comparative Example 1: Based on Example 2, pomegranate peel powder, rosemary powder and Piper longum powder were not added, and the other processes remained unchanged.

[0038] Comparative Example 2: Based on Example 2, without adding rosemary powder and Piper longum powder, the other processes remain unchanged.

[0039] Comparative Example 3: Based on Example 2, pomegranate peel powder and Piper longum powder were not added, and the other processes remained unchanged.

[0040] Comparative Example 4: Based on Example 2, pomegranate peel powder and rosemary powder were not added, and the other processes remained unchanged.

[0041] Comparative Example 5: Based on Example 2, epigallocatechin gallate was not added, and the other processes remained unchanged.

[0042] Comparative Example 6: Based on Example 2, without adding glycerol, xanthan gum and cyclodextrin, the ratio of propylene glycol-water solvent in the oil-water mixed solvent was changed from (7:3, w / w) to (0:10, w / w), and the rest of the process remained unchanged.

[0043] Comparative Example 7: Based on Example 2, the ratio of the oil-water mixed solvent propylene glycol-water solvent was changed from (7:3, w / w) to (10:0, w / w), and the rest of the process remained unchanged.

[0044] Comparative Example 8: Based on Example 2, the ratio of propylene glycol to water solvent in the oil-water mixed solvent was changed from (7:3, w / w) to (5:5, w / w), and the rest of the process remained unchanged.

[0045] Comparative Example 9: Based on Example 2, the ratio of the oil-water mixed solvent propylene glycol-water solvent was changed from (7:3, w / w) to (3:7, w / w), and the rest of the process remained unchanged.

[0046] Comparative Example 10: Based on Example 2, the ratio of propylene glycol to water solvent in the oil-water mixed solvent was changed from (7:3, w / w) to (0:10, w / w), and the rest of the process remained unchanged.

[0047] Product performance verification method: Alcohol dehydrogenase activity determination method: Sodium pyrophosphate buffer (1.5mL, pH=8.8), NAD+ (nicotinamide adenine dinucleotide) (1mL, 0.027mol / L), alcohol dehydrogenase solution (0.1mL, 2.5U / mL) and 0.1mL sample solution (composition solution obtained in the embodiment) were added to the test tube in sequence, mixed thoroughly and placed at 25°C. The same four test tubes with the above reagents were reacted for 10min, 30min, 1h, and 2h respectively. After the reaction, ethanol solution (0.5mL, 5%) was added immediately. The absorbance value was measured at 340nm with an ELISA reader, and the reading was taken every 1min for 10min. The blank group was replaced with sodium pyrophosphate buffer instead of sample solution.

[0048] Alcohol dehydrogenase activity = (A×3.2) / (Ew×6.2) A is the increase in the initial absorbance value of the reaction per minute, 3.2 is the total reaction volume (mL), Ew is the enzyme content in the enzyme solution, and 6.2 is the extinction coefficient.

[0049] Antioxidant activity determination method: The ability of ascorbic acid to scavenge DPPH free radicals was determined to characterize the antioxidant capacity of ascorbic acid. DPPH (0.012 mmol / L) solution was prepared by mixing 0.5 mL of DPPH solution with 0.1 mL of sample using ethanol as solvent. 1 mL of pure water was added to dilute the sample, the mixed solution was incubated in a 25°C water bath for 20 min, and then the absorbance (AS) at 515 nm was measured. The DPPH solution was used as a blank sample, and its absorbance (AB) was measured. The calculation formula for the scavenging rate of DPPH free radicals is: DPPH free radical scavenging rate = (AB-AS) / AB Where: AS = absorbance of sample; AB = absorbance of blank sample.

[0050] Stability determination method: Place the prepared samples in a constant temperature and humidity chamber at 54°C and 70%RH for 2 weeks to observe whether there is precipitation or stratification.

[0051] Table 1 Experimental results: ; The purpose of comparative example 6 is to verify the stability of the embodiment, which is meaningless in the experiment here, so the data of comparative example 6 is not included. It can be seen from the above table that by adjusting the formula, the alcohol dehydrogenase activation rate and antioxidant activity of embodiments 1-3 are higher than those of comparative examples 1-5; By adjusting the process, the best alcohol dehydrogenase activation rate was achieved when the propylene glycol-water mixed extraction solvent ratio was 3:7.

[0052] The stability test results are shown in Figure 2 : Figure 2 The upper left container is the sample solution of Example 2, and the lower left container is the sample solution of Example 2 after being placed for two weeks. Figure 2 The upper right container contains the sample solution of Comparative Example 6, and the lower right container contains the sample solution of Comparative Example 6 after being placed for two weeks. Figure 2 It can be seen that through the improvement of the formula (Example 2), the product stability is better, and there is no phenomenon such as stratification and precipitation.

[0053] The embodiments of the present disclosure have been described above, and the above description is exemplary, not exhaustive, and is not limited to the disclosed embodiments. Many modifications and changes will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The selection of terms used herein is intended to best explain the principles of the embodiments, practical applications, or technical improvements in the market, or to enable other persons of ordinary skill in the art to understand the embodiments disclosed herein.

Claims

1. A composition having a hangover-relieving effect, characterized in that: Including main ingredients and auxiliary materials: The main components include, by weight: 50-90 parts of kudzu root powder, 30-50 parts of kudzu flower powder, 30-50 parts of Hovenia dulcis powder, 20-40 parts of pomegranate peel powder, 20-40 parts of rosemary powder, 20-40 parts of Piper longifolia powder, and 0.5-1.0 parts of epigallocatechin gallate; The auxiliary materials include: 0-10 parts of propylene glycol, 0-5 parts of glycerol, 0-0.3 parts of cyclodextrin, and 0-0.2 parts of xanthan gum.

2. A preparation process of a composition having an alcohol sobering effect, characterized in that: The preparation process is used to prepare the composition according to claim 1, and the preparation process comprises the following steps: S1: Weigh various plant components in a set proportion, mix the weighed plant components evenly, extract them using a dual extraction process of alcohol precipitation and oil-water mixing, and filter to obtain an extract; S2: Heat the extract obtained in S1 to 45-65°C, add a stabilizer, let stand for 30 minutes to allow the components to fully swell, and then stir evenly; S3: epigallocatechin gallate is added to 95 parts of pure water in sequence, and stirred to obtain a clear aqueous solution; S4: adding the aqueous solution obtained in S3 to the solution obtained in S2 three times, stirring for 5 minutes each time, and obtaining a composition having a hangover sobering effect after the stirring is completed.

3. The preparation process according to claim 2, characterized in that: In step S1, the oil-water mixed solvent is a propylene glycol-water mixed solvent, and the ratio of propylene glycol to water is one of 10:0, 7:3, 5:5, 3:7, and 0:

10.

4. The preparation process according to claim 2, characterized in that: In step S1, the extraction method is ultrasonic extraction, the extraction temperature is 0-75°C, and the extraction time is 0-60 minutes.

5. The preparation process according to claim 2, characterized in that: In step S2, the stabilizer is one or more of propylene glycol, glycerol, cyclodextrin, and xanthan gum.

6. The preparation process according to claim 2, characterized in that: The extraction is performed by a dual extraction process of alcohol precipitation and oil-water mixing, including: using 150 parts of 55% food-grade ethanol for extraction, stirring while heating, the stirring temperature is 60°C, the stirring time is 30 minutes, filtering after completion, drying the filtrate at 50°C, drying to a remaining volume of only 10 mL, adding 20 mL of a mixed solvent of propylene glycol and water in a mass ratio of 7:3 for ultrasonic extraction, the extraction temperature is 50°C, the extraction time is 30 minutes, and filtering to obtain an extract.

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