Portable self-heating two-component medicine generator, two-component medicine and preparation method of two-component medicine

Abstract

The invention provides a portable self-heating two-component medicine generator, a two-component medicine and a preparation method of the two-component medicine. The release mechanisms of the effective components of the two medicament carriers are different, so that the effective components are released permanently and stably and enter heart blood through a respiratory system, and the rescue time is effectively prolonged for patients suffering from acute myocardial infarction. The preparation method comprises the following steps: step 1, preparing an established prescription, and crushing the prepared prescription into two kinds of granular powder, namely medicinal powder A and medicinal powder B; 2, soaking the medicine powder A with ethanol to prepare a concentrated solution, adding an adsorption material into the concentrated solution, standing for 4-12 hours, filtering, and performing low-temperature vacuum drying to prepare A; step 3, fully and uniformly mixing corn flour, starch and medicinal powder B according to a ratio of (2-3): (0.5-1): (1-3) to prepare B for later use; and step 4, mixing A and B according to a mass ratio of 1: (2-3), adding water after mixing, stirring and dispersing to obtain a mixture A and a mixture B, and granulating and drying through a screen to obtain the double-component medicine.

Description

Technical Field

[0001] The invention relates to medical and health care products, in particular to a portable self-heating two-component medicine generator, a two-component medicine and a preparation method of the two-component medicine. Background Art

[0002] Fumigation is the process of placing some Chinese herbal medicines that have not been specially processed, refined or refined into a sealed container. container The patient enters the lungs through the mouth and nose with the breath, directly through the lungs organ Absorption Blood Enters the systemic circulation, thereby playing a drug therapeutic role.

[0003] This method is a scientific and reasonable medication method based on the characteristics of human physiological functions. Its principle is continuous arterial medication. First, the "fumigation therapy" sublimates the specially prepared Chinese herbal medicine into drug particles of varying sizes, which directly and quickly penetrate the respiratory membrane or deposit on the surface of the alveoli and respiratory bronchus and are gradually and slowly inhaled into the pulmonary vein to exert an immediate or longer-term continuous therapeutic effect. Secondly, the absorbed drug particles flow into the left heart through the pulmonary venous blood and then perfuse the whole body (including the lesion site). Therefore, each heartbeat is like an arterial medication, that is, when the patient inhales the medication, within 3 to 5 minutes (each inhalation lasts 3 to 5 minutes), it is equivalent to continuous arterial medication (part of the drug particles rapidly absorbed) 200 to 300 times; within 15 to 20 days after inhalation (fumigation is performed once every 15 to 20 days), it is equivalent to continuous arterial medication (part of the drug particles gradually absorbed) 1.5 million to 2 million times. At the same time, it is precisely because of this long-term continuous arterial medication that the drug is reduced inactivated by the liver metabolism, the reduction in drug dosage caused by biotransformation, and the drug barrier effect of the liver reduces the efficacy (the so-called first checkpoint effect), which has a huge impact on treatment. In addition. Fumigation medication also avoids the long absorption process of "oral" and the susceptibility of some drug components to the effects of gastrointestinal contents and intestinal flora; it avoids patients who are not suitable for oral administration and are in coma, convulsions, vomiting, children, mentally ill and other uncooperative patients; it avoids the inconvenience, economy and safety of "injection", and avoids the limitations of "sublingual tablets" and "rectal suppositories" or "rectal enemas", which are only applicable to a few drugs that easily penetrate the mucous membrane; and it is also different from the route of "inhalation" of volatile or gaseous drugs. Therefore, fumigation medication has the advantages of being effective, safe, convenient, cost-saving and pain-free for patients, and is used as the main means of treating many diseases.

[0004] Because "fumigation therapy" is inhaled through the respiratory tract, it can directly enter the arteriovenous blood leading to the heart and can reach the lesion most directly and quickly. It solves the shortcomings of current sublingual emergency medicines that need to pass through the mucous membrane to enter the extracirculatory blood or oral medicines that need to pass through the long digestive tract before being absorbed, resulting in a long onset time and poor emergency treatment effect for sudden stroke. It solves the emergency needs of sudden diseases in unspecified places, such as sudden heart disease and sudden cerebral infarction. The self-heating device is used to load the active ingredients of specific formula drugs, which can be carried with you for emergency treatment in emergencies.

[0005] The existing technology of self-heating evaporation of active ingredients that are inhaled into the respiratory tract to treat diseases has the following problems: 1. All homogeneous raw material powder drugs evaporate and volatilize after heating and are inhaled to take effect. Under the same quality of the device, the concentration of active drug ingredients inhaled is low when the original medicinal material powder is used alone, and there is a problem of small active ingredient loading; for the advance health care means of acute attacks, high concentrations of active ingredients entering the relevant system are the necessary choice to relieve the critical state as quickly as possible. This has long been verified by the basic principles of chemical thermodynamics and chemical kinetics, that is, serious diseases still require serious medicines; and the existing use of original medicinal material powder as the source of effective components is limited to the original medicinal materials. 1. The content of active ingredients is low, and during the evaporation process, the concentration of active ingredients in the gas phase is seriously low, and it cannot act on the pathogenic reaction system at a high dose; 2. If the active ingredient extract (aromatic ingredients are insoluble in water) is simply used as the evaporated body, the storage period is short due to its flammability and volatility, most of them are flammable and unsafe, and the liquid phase is inconvenient to package and carry; 3. The previous self-heating volatilization inhalation drugs and devices, the raw material powder method has the problem of rapid decay of the concentration of active ingredients in the gas phase during the heating process, making it difficult to provide balanced, long-lasting and rapid high concentrations to the respiratory system, and it is difficult to maintain the balance and persistence of pulmonary artery blood drug concentrations, which has a great impact on the quality of heart and brain blood supply.

[0006] Insufficient blood supply to the myocardium and brain tissue is a common disease in the middle-aged and elderly, with varying degrees of severity. From the perspective of modern anatomy, the root cause of insufficient blood supply to the heart and brain lies in the liver and lung function; from the perspective of traditional Chinese medicine theory, it lies in the insufficiency of the liver, lungs, spleen and kidneys; in short, it is the result of functional degeneration. The reason why people work during the day and rest at night is that organs, especially the liver, need to rest and recuperate. Therefore, those who work overload and lack sleep are prone to insufficient blood supply to the heart and brain due to insufficient metabolic substrates; patients with type 2 blood sugar (including those with poor basic physical fitness) often suffer from myocardial ischemia because of insufficient peripheral tissue energy metabolism (deficiency and coldness) and decreased liver, lung and kidney function; blood activity suddenly decreases, and myocardial cells (brain cells) suddenly decrease due to energy conversion, causing myocardial infarction (ischemic cerebral infarction)! For example, severe lack of sleep, colds causing lung inflammation, or other sudden physical energy consumption, such as trauma (surgery), radiotherapy and chemotherapy, etc., as long as they are external factors that seriously consume energy or reduce tissue activity, they will also cause such patients to suffer from sudden cardiovascular and cerebrovascular emergencies.

[0007] If at this time, when the metabolic quality declines, we can adhere to the method of "not enough quality, make up for it with quantity", that is, improve the rheology of the blood (the peripheral osmotic penetration ability of the blood) in the shortest possible time, thereby increasing the blood flow in the tissues (the amount of blood exchanged in the tissues per unit time), then we can improve the dual metabolic efficiency of tissue cells in the shortest possible time period, and myocardial infarction (cerebral ischemia) will naturally be relieved.

[0008] There are few options for Chinese and Western medicines or technologies. Acupuncture or adrenal hormones also require specific judgment before a specific plan can be formed for treatment. But doctors are not always around.

[0009] Although the principle of this method and product is crude, it can relieve or resolve sudden cardiac and cerebral emergencies anytime and anywhere. Summary of the invention

[0010] In order to solve the problems of the prior art, the present invention provides a portable self-heating two-component drug generator, a two-component drug and a method for preparing the two-component drug. The two drug carriers of the present invention have different release mechanisms of the active ingredients, which can make the active ingredients more persistent and stable and directly enter the heart blood, thereby extending the time for medical personnel to arrive for rescue.

[0011] The technical solution of the present invention is:

[0012] A method for preparing a two-component drug, the method comprising the following steps:

[0013] Step 1: After preparing the prescribed prescription, crush it into two kinds of powders, namely, powder A and powder B, wherein the particle size of powder A is coarser than that of powder B;

[0014] Step 2: extract the powder A in a reflux extraction device according to the following process: soak it in 70-75% ethanol, extract the concentrated solution, add the concentrated solution to the adsorption material, let it stand for 4-8 hours, filter and dry (the remaining ethanol can be recovered) to prepare component A;

[0015] Step 3: mix corn flour, starch and powder B in a ratio of 2-3:0.5-1:1-3 to prepare component B for later use;

[0016] Step 4: fully mix component A and component B in a mass ratio of 1:2-3, add purified water and stir after mixing, granulate through a 15-25 mesh sieve, and dry to obtain a two-component drug.

[0017] Furthermore, the particle size of the medicine powder A is 5 to 20 meshes.

[0018] Furthermore, the particle size of the medicine powder B is 30-60 mesh.

[0019] Furthermore, the adsorption material is activated carbon particles of 10 to 30 meshes.

[0020] A two-component medicine is prepared by the above preparation method.

[0021] A two-component medicine package comprises a medicine package body made of a breathable material, wherein the two-component medicine is loaded into the medicine package body.

[0022] A two-component medicine comprises component A and component B, wherein component A is made of an adsorbent material soaked in a medicine solution, and component B contains medicine powder.

[0023] A portable two-component drug generator comprises a drug containing chamber with two connecting ports and a ventilation channel, wherein the two connecting ports of the drug containing chamber are respectively connected with a bottom plate with mesh holes, the drug containing chamber contains a two-component drug package between the two bottom plates, a heating device is arranged on one side of the two-component drug package, the ventilation channel is connected with one of the connecting ports, and the other end of the ventilation channel and the other connecting port are respectively covered with sealing members.

[0024] Further, it comprises a cylinder, wherein the two bottom plates are fixed on the inner circumferential surface of the cylinder at intervals, the cylinder space between the two bottom plates constitutes a drug containing chamber, and the cavity in the upper part of the cylinder constitutes a ventilation channel;

[0025] The heating device is a self-heating bag arranged on the side of the bottom plate at the bottom;

[0026] The sealing member is sealingly connected to the upper and lower end openings of the cylinder, and the sealing member is detachably connected to the cylinder;

[0027] The two-component medicine package is placed on the upper side of the self-heating package.

[0028] Furthermore, the sealing member is a plastic cover or an aluminum foil.

[0029] The beneficial effects of the present invention are:

[0030] 1. After heating, component A of the two-component medicine of the present invention can quickly release high-concentration active ingredients, while component B releases the active ingredients slowly and persistently because the active ingredients need to diffuse from the inside to the outside of the wood fiber and need to absorb a large amount of energy, thereby achieving the purpose of entering the respiratory tract with the maximum concentration in the shortest time to relieve insufficient blood supply to the heart and brain through the rapid and high-concentration release of active ingredients by component A in the initial heating state, and continuous heating enables component B to slowly and persistently release more active ingredients after the heat is increased. Component A and component B complement each other, so that the active ingredients are released quickly, at a high concentration and persistently to treat patients;

[0031] 2. Component A is adsorbed after the adsorption material extracts and concentrates the original formula drug powder particles. Compared with the original drug powder, under the same quality, the active ingredient content of component A is more than 3 to 6 times that of component B. It has the characteristics of high active ingredient content, rapid desorption by short-term heating at low temperature, and rapid change of arterial blood rheology, thus meeting the needs of fast and efficient emergency treatment, and solving the problem of slow onset, weak strength, and poor effect of severe acute myocardial ischemia when using raw materials alone. According to experiments, the pure drug powder of component A takes 6 to 10 seconds to take effect, and then needs to be taken orally to completely relieve it. The invention example can take effect within 3 to 5 seconds, and those with mild symptoms do not need to take medicine.

[0032] 3. The drug generator of the present invention is easy to carry by self-heating, can quickly and permanently provide effective ingredients to patients for inhalation treatment, and can be used for emergency purposes anytime and anywhere. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 This is a stereoscopic diagram of the portable self-heating two-component drug generator of the present invention;

[0034] Figure 2 It is a cross-sectional view of the portable self-heating two-component drug generator of the present invention;

[0035] Figure 3 It is a sectional stereoscopic diagram of the portable self-heating two-component drug generator of the present invention.

[0036] Reference numerals in the figure: cylinder 1, bottom plate 2, self-heating bag 3, sealing element 4, two-component medicine bag 5. DETAILED DESCRIPTION

[0037] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present invention is further described below through specific embodiments.

[0038] A method for preparing a two-component drug, characterized in that the preparation method comprises the following steps:

[0039] Step 1: After preparing the prescribed prescription, crush it into two kinds of powders, namely, powder A (5-20 meshes) and powder B (30-60 meshes), wherein the particle size of powder A is coarser than that of powder B;

[0040] Step 2, extracting the powder A in a reflux extraction device according to the following process: soaking the solid particles in 70-75% ethanol (by volume) about 1 / 3 higher than the solid particles (and maintaining), refluxing in the reflux extraction device for one to three hours, distilling and recovering more than 50% to 90% of the total amount of ethanol, adding the concentrated solution to a refined granular adsorption material, such as 10-30 mesh refined activated carbon particles, standing for adsorption for 4-8 hours, filtering under reduced pressure, and drying under reduced pressure (the remaining ethanol can be recovered) to prepare component A;

[0041] Step 3: mix corn flour, (medicinal) starch and drug powder B in a ratio of 2-3:0.5-1:1-3 to prepare component B for later use;

[0042] Step 4: Mix component A and component B in a mass ratio of 1:2-3, add an appropriate amount of purified water and mix thoroughly to form a mixture of components AB, granulate through a 15-25 mesh sieve, and dry under vacuum at low temperature to obtain a two-component drug.

[0043] A two-component medicine is prepared by the above preparation method.

[0044] A two-component medicine package comprises a medicine package body made of a breathable material, wherein the two-component medicine is loaded into the medicine package body.

[0045] A portable self-heating two-component drug generator is provided. 25-35 grams of the two-component drug is loaded into a self-heating device, and a porous (>35 mesh) aluminum foil is covered on the drug powder particles. The self-heating device can be structured as follows: take an iron cylinder with a porous bottom (the number of holes in the barrel bottom is >10 mesh) and a diameter of 3-6 cm, apply a self-heating material composed of reducing iron powder and heat-resistant filler such as vermiculite powder in a ratio of 1:3-10 to the bottom of the barrel, and apply a porous aluminum plate (>30 mesh) on it; the upper and lower openings of the cylinder are closed with plastic lids of the same diameter. When needed, the upper and lower lids can be opened and placed close to the nostrils.

[0046] Embodiment 1, a method for preparing a two-component drug, the preparation method comprising the following steps:

[0047] Step 1: After preparing the prescribed prescription, crush it into two kinds of powder particles, namely, powder A (5 mesh) and powder B (30 mesh);

[0048] Step 2: extract the powder A in a reflux extraction device according to the following process: soak it in 70% ethanol, reflux it in the reflux extraction device for one hour, distill and recover 50% of the total amount of ethanol, add 30-mesh refined activated carbon particles to the concentrate, let it stand for adsorption for 4 hours, filter the soaked activated carbon particles under reduced pressure, and dry them under reduced pressure (the remaining ethanol can be recovered) to prepare component A;

[0049] Step 3: Mix corn flour, (medicinal) starch and drug powder B in a mass ratio of 2:0.5:1 to prepare component B for later use;

[0050] Step 4: fully mix component A and component B in a mass ratio of 1:2, add an appropriate amount of purified water after mixing, granulate through a 15-mesh sieve, and dry under vacuum at low temperature to obtain a two-component drug.

[0051] A two-component medicine package includes a medicine package body made of a breathable material, wherein the breathable material is a porous (pores>35 mesh) aluminum foil. The two-component medicine is placed in the medicine package body. The medicine package body can also be made of medical non-woven fabric.

[0052] A portable two-component drug generator comprises a drug containing chamber with two connecting ports and a ventilation channel, wherein the two connecting ports of the drug containing chamber are respectively connected to bottom plates with meshes, a two-component drug package between the two bottom plates is contained in the drug containing chamber, a heating device is arranged on one side of the two-component drug package, the ventilation channel is connected to one of the connecting ports, and the other end of the ventilation channel and the other connecting port are respectively covered with sealing members.

[0053] Further, it comprises a cylinder, wherein the two bottom plates are fixed on the inner circumferential surface of the cylinder at intervals, the cylinder space between the two bottom plates constitutes a drug containing chamber, and the cavity in the upper part of the cylinder constitutes a ventilation channel;

[0054] The heating device is a self-heating bag arranged on the upper side of the bottom plate at the bottom; the heating device there can also be replaced with electric heating.

[0055] The sealing member is sealingly connected to the upper and lower end openings of the cylinder, and the sealing member is detachably connected to the cylinder;

[0056] The two-component medicine package is located on the upper side of the self-heating package.

[0057] Furthermore, the sealing member is a plastic cover or an aluminum foil. The plastic cover can be connected to the cylinder by threads, and a sealing ring is pressed between the plastic cover and the end of the cylinder to ensure the sealing performance. When the aluminum foil is used for sealing, the aluminum foil is sealed on the upper and lower end openings of the cylinder by a sealing machine.

[0058] When preparing the drug generator, the bottom plate at the lower end of the cylinder can be fixed integrally with the cylinder, or can be screwed on by threads. After the bottom plate at the lower end is fixed, the self-heating bag is placed on the bottom plate, and then the medicine bag containing the two-component medicine is placed on the self-heating bag, and then the bottom plate at the upper end is pressed on the medicine bag to fix the medicine bag and the self-heating bag. The bottom plate at the upper end can be connected to the cylinder by threads. In this way, after using the self-heating bag and the medicine bag once, a new self-heating bag and the medicine bag can be replaced. At this time, the seal at the upper end needs to be sealed with a plastic cover, which is convenient for replacement.

[0059] Embodiment 2, a method for preparing a two-component drug, the preparation method comprising the following steps:

[0060] Step 1: After preparing the prescribed prescription, crush it into two kinds of powders, namely, powder A (12 mesh) and powder B (45 mesh), wherein the particle size of powder A is coarser than that of powder B;

[0061] Step 2: extract the powder A in a reflux extraction device according to the following process: soak it in 75% ethanol, reflux it in the reflux extraction device for one to three hours, distill and recover more than 50% of the total amount of ethanol, add 20-mesh activated carbon particles to the concentrate, let it stand for adsorption for 6 hours, filter it under reduced pressure, and dry it under reduced pressure (the remaining ethanol can be recovered) to prepare component A;

[0062] Step 3: Mix corn flour, (medicinal) starch and drug powder B in a ratio of 3:1:2 to prepare component B for later use;

[0063] Step 4: fully mix component A and component B in a mass ratio of 1:3, add an appropriate amount of purified water after mixing, granulate through a 20-mesh sieve, and dry under vacuum at low temperature to obtain a two-component drug.

[0064] Embodiment 3, a method for preparing a two-component drug, characterized in that the preparation method comprises the following steps:

[0065] Step 1: After preparing the prescribed prescription, crush it into two kinds of powders, namely, powder A (20 mesh) and powder B (60 mesh), wherein the particle size of powder A is coarser than that of powder B;

[0066] Step 2: extract the powder A in a reflux extraction device according to the following process: soak it in 75% ethanol, reflux it in the reflux extraction device for three hours, distill and recover more than 50% of the total amount of ethanol, add the concentrated solution to a refined adsorption material, such as 10-mesh refined activated carbon particles, let it stand for adsorption for 8 hours, filter it under reduced pressure, and dry it under reduced pressure (the remaining ethanol can be recovered) to prepare component A;

[0067] Step 3: Mix corn flour, (medicinal) starch and drug powder B in a ratio of 3:1:3 to prepare component B for later use;

[0068] Step 4: fully mix component A and component B in a mass ratio of 1:3, add an appropriate amount of purified water after mixing, granulate through a 25-mesh sieve, and dry under vacuum at low temperature to obtain a two-component drug.

[0069] Embodiment 4, a method for preparing a two-component drug, characterized in that the preparation method comprises the following steps:

[0070] Step 1: After preparing the prescribed prescription, crush it into two kinds of powders, namely, powder A (5 mesh) and powder B (30 mesh), wherein the particle size of powder A is coarser than that of powder B;

[0071] Step 2: extract the powder A in a reflux extraction device according to the following process: soak it in 75% ethanol, reflux it in the reflux extraction device for three hours, distill and recover more than 50% of the total amount of ethanol, add refined, such as 10-mesh refined activated carbon particles, let it stand for adsorption for 8 hours, filter it under reduced pressure, and dry it under reduced pressure (the remaining ethanol can be recovered) to prepare component A;

[0072] Step 3: Mix corn flour, (medicinal) starch and drug powder B in a ratio of 2:0.5:1 to prepare component B for later use;

[0073] Step 4: fully mix component A and component B in a mass ratio of 1:2, add an appropriate amount of purified water after mixing, granulate through a 15-mesh sieve, and dry under vacuum at low temperature to obtain a two-component drug.

[0074] Of course, the above embodiments are only some embodiments of the present application. Within the parameter value range of the present application, embodiments with any values ​​are within the protection scope of the present application.

[0075] Serious illnesses require serious medication (dosage and duration of medication), for hypertensive crisis, myocardial infarction, stroke

[0076] Acute high-risk diseases such as cerebral and hepatic hemangioma, and ruptured arterial dissection require large doses and long-lasting drug effects (principles of drug thermodynamics and kinetics). Assuming that the above-mentioned methods are needed for first aid relief while waiting for emergency personnel, it is natural that the first aid methods are fast-acting, strong, and long-lasting to save the patient's life.

[0077] For example, the active ingredient medicine described in the invention can be composed of the following formula: Chuanxiong, Asarum, Borneol, etc. constitute the main medicine group; Acorus calamus, Angelica dahurica, Aquilaria wood, Dalbergia odorifera, Curcuma aromatica, Curcuma longa, Rhubarb, Red Peony Root, Angelica sinensis, Peach Kernel, Apricot Kernel, etc. constitute the auxiliary medicine group.

[0078] Instructions for use: When heart and brain discomfort occurs, open the upper and lower sealing covers. Under the action of air oxygen, reducing iron powder and other easily oxidizable substances react to release heat (self-heating bag). The medicine bag placed on the upper part of the self-heating bag (the medicine bag and the self-heating bag are in contact) is heated. First, the adsorbed particles wrapped in the particles release effective volatile drugs, and then the original drug powder mixture of component A is heated to evaporate the effective drugs, which enter the respiratory tract, are absorbed through the mucous membrane and quickly enter the arterial blood, quickly reaching the site of myocardial and cerebral infarction.

[0079] The principle of the present invention is summarized as follows: 1. The material for adsorbing effective ingredients in the present invention serves as a heated component, namely component A; 2. The starch-corn flour-coated particles of the original medicinal powder serve as a heated component, namely component B; 3. The two carrier components are combined to form a self-heating respiratory medication device that can provide rapid release, high concentration, and long-lasting; 4. The method of using a mixture of corn flour and medicinal starch as an adhesive material is because corn flour is naturally harmless and has better certain adsorption properties, so that the effective ingredients that escape from the original medicinal powder are locked in the corn flour, keeping the effective ingredients from being lost.

[0080] Claimed to be protected: A drug delivery method for sequentially and sustainedly releasing active ingredients by mixing a solid carrier for absorbing active ingredients and related effective drug powders with corn powder and starch to form a biphasic drug delivery method.

[0081] Analysis of the technical effect of the present invention: before the upper and lower covers are opened and the self-heating material has not yet reached a sufficient temperature, the first active ingredient emitted by the device of the present invention comes from component B, that is, the self-volatilization phenomenon of the original drug powder. However, since the original drug particles are covered by the coating layer composed of starch and corn flour and absorbed by the corn flour, the amount is relatively small; when the drug is heated to above 40 degrees, in the first stage: because the active ingredients in component A are adsorbed inside the adsorption material by the non-molecular force coupling of the porous structure, and the binding force between the active ingredients and the adsorption material is smaller than the intermolecular force between the wood fiber and the active ingredients in the original drug powder, component A is first released quickly (in the early stage of heating, only a small amount of volatiles absorbed by the corn flour-starch coating layer during the storage period are also released at the same time, and this process only takes a few seconds); thereafter, as the temperature rises, the rapid release of component A provides a high concentration of active substances in the respiratory gas phase. The second stage: in the process of gradual heating, the substances released by component A gradually decrease, and the active ingredients released by component B when it is above 50 degrees also gradually increase. At this time, the active ingredients in the respiratory gas phase reach a peak value, which takes about 1 to 3 minutes. The third stage: The effective substances released by raw materials A and B gradually decay.

Claims

1. A method for preparing a two-component drug, characterized in that: The preparation method comprises the following steps: Step 1: After preparing the prescribed prescription, crush it into granular powder, which is divided into medicine powder A and medicine powder B; Step 2: extract the powder A in a reflux extraction device according to the following process: extract the concentrated solution after soaking with ethanol, add the concentrated solution to the adsorption material, let it stand for adsorption, filter and retain the adsorption material and dry it to prepare component A; Step 3: Mix the powder with adsorption function, the medicinal adhesive and the powder B evenly to prepare component B for later use; Step 4: Mix component A and component B, add purified water after mixing, stir and disperse to form a mixture of components AB, granulate through a sieve, and dry to obtain a two-component granular drug.

2. The method for preparing a two-component drug according to claim 1, characterized in that: After the predetermined prescription is prepared, it is crushed into two kinds of powders, namely, powder A and powder B. The particle size of powder A is coarser than that of powder B.

3. The method for preparing a two-component drug according to claim 1, characterized in that: The particle size of the medicine powder A is 5-20 meshes, the particle size of the medicine powder B is 30-60 meshes, the ethanol in step 2 is 70-75% ethanol, the static adsorption time in step 2 is 4-12 hours, the mass ratio of the powder with adsorption function, the medicinal adhesive and the medicine powder B in step 3 is 2-3:0.5-1:1-3, and the mass ratio of component A to component B in step 4 is 1:2-5.

4. The method for preparing a two-component drug according to claim 1, characterized in that: The adsorption material is activated carbon with a mesh size of 10 to 30 or activated diatomaceous earth particles, the powder with adsorption function is corn flour, and the medicinal adhesive is starch.

5. A two-component drug, characterized in that: The two-component medicine is prepared by any preparation method of claims 1-4.

6. A two-component drug package, characterized in that: It comprises a medicine package body made of a breathable material, wherein the two-component medicine as claimed in claim 5 is filled in the medicine package body.

7. A two-component drug, characterized in that: After the established prescription is prepared, the powder is crushed into particles and divided into powder A and powder B. Component A is made of an adsorbent material that has been soaked in a drug solution made of powder A, and component B is a powder containing drug. The two-component medicine contains component A and component B.

8. A portable two-component drug generator, comprising a drug containing chamber with two connecting ports and a ventilation channel, wherein the two connecting ports of the drug containing chamber are respectively connected with a bottom plate with a mesh, and the drug containing chamber contains a two-component medicine package between the two bottom plates, wherein the two-component medicine package is the medicine package as claimed in claim 6, and a heating device is provided on one side of the two-component medicine package, the ventilation channel is connected with one of the connecting ports, and the other end of the ventilation channel and the other connecting port are respectively covered with sealing members.

9. A portable two-component drug generator according to claim 8, characterized in that: It comprises a barrel (1), two bottom plates (2) fixed at intervals on the inner circumferential surface of the barrel (1), the space of the barrel (1) between the two bottom plates (2) forming a drug containing chamber, and the cavity in the upper part of the barrel (1) forming a ventilation channel; The heating device is a self-heating bag (3) arranged on the upper side of the bottom plate (2) at the bottom; The sealing member (4) is sealingly connected to the upper and lower end openings of the cylinder (1), and the sealing member (4) is detachably connected to the cylinder (1); The two-component medicine package (5) is placed on the upper side of the self-heating package (3).

10. A portable two-component drug generator according to claim 9, characterized in that: The sealing member (4) is a plastic cover or an aluminum foil.

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