Application of isodan leaf emodin in preparation of anti-glioma drugs
Through isodyniae emodin regulating the AMPK/mTOR signaling pathway and degrading Snail/Slug, the problem of tolerance of glioma cells to existing treatment methods is solved, and the effect of effectively inhibiting glioma cell proliferation and recurrence is achieved, and the patient's survival is extended.
CN119909047APending Publication Date: 2025-05-02THE SECOND AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY
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Patent Information
- Application Number
- CN202510118713.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-24
- Publication Date
- 2025-05-02
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Figure CN119909047A_ABST
Abstract
The invention discloses an application of isodan leaf emodin in preparation of an anti-glioma drug, and belongs to the technical field of biological medicines. The traditional Chinese medicine monomer component isodan leaf emodin disclosed by the invention not only can effectively inhibit glioma cell proliferation, but also can induce tumor cells to generate autophagy by regulating and controlling an AMPK / mTOR signal channel, realizes EMT reversion by selectively degrading a transcription factor Snail / Slug, and reduces the invasion and migration ability of glioma cells; the anti-glioma related drug provided by the invention can effectively inhibit the growth of malignant glioma, and becomes a potential targeting drug for resisting glioma relapse. The medicine not only can induce glioma cells to generate autophagy in vitro, but also can play a role in inhibiting glioma growth in vivo.
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