Traditional Chinese medicine composition for treating halitosis and dry mouth as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for treating halitosis and dry mouth as well as a preparation method and application thereof. The traditional Chinese medicine composition comprises 15-50 parts of prepared radix polygonati officinalis, 15-50 parts of fresh dendrobium, 15-50 parts of oriental wormwood, 15-50 parts of roasted folium eriobotryae, 6-15 parts of coptis chinensis, 6-20 parts of uncaria rhynchophylla, 6-20 parts of scorched hawthorn fruit, 3-12 parts of mint and 10-30 parts of bran immature bitter orange. The traditional Chinese medicine composition disclosed by the invention not only aims at the common etiology and pathogenesis of the halitosis and xerostomia at present, but also plays the effects of nourishing yin, clearing heat, dissolving turbidity and removing urine urine through oral administration and gargling, treats both symptoms and root causes, can inhibit local bacteria in the oral cavity, quickly improves the symptoms of halitosis and xerostomia, and also treats the main symptoms such as bitter mouth, sticky and unsmooth mouth and the like; the traditional Chinese medicine composition is convenient to use, rapid in symptom improvement, remarkable in curative effect, safe, free of toxic and side effects and convenient for daily use of patients.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition for treating halitosis and dry mouth, as well as a preparation method and application thereof. Background Art

[0002] Bad breath, also known as bad breath, refers to the odor emitted from the mouth or other air-filled cavities such as the nose, sinuses, and pharynx. Bad breath seriously affects people's social interactions and mental health. The World Health Organization has reported bad breath as a disease. Dry mouth refers to the symptom of dry mouth discomfort, which can be seen in many diseases such as Sjögren's syndrome and diabetes, and is often accompanied by bad breath, bitter mouth, and sticky mouth. It is currently believed that bad breath and dry mouth are closely related to respiratory diseases (local infections of the nasal cavity, maxillary sinus, pharynx, etc.), digestive system diseases (gastritis, gastric ulcers, constipation, etc.), systemic diseases (diabetes, etc.), and local oral diseases (dental caries, periodontitis, etc.).

[0003] At present, the treatment of pathogenic halitosis and dry mouth is mainly focused on the treatment of the primary disease. For the more common simple halitosis and dry mouth, there is no specific treatment for organic lesions found in the examination. The general treatment is mainly based on Chinese herbal decoctions, as well as auxiliary methods such as increasing water intake, improving oral hygiene, using breath fresheners, chewing gum, etc.

[0004] It is generally believed that the occurrence of simple halitosis and dry mouth is related to spleen deficiency and dampness. The traditional Chinese medicine combination treatment focuses on strengthening the spleen and removing dampness. Common therapeutic drugs include Patchouli, Perilla, Poria, stir-fried Atractylodes macrocephala, Licorice, etc. After clinical application, it was found that the current common pathogenesis of halitosis and dry mouth is not well targeted, the efficacy is unstable, and the clinical application has great limitations. In addition, the route of medication is oral decoction, which is difficult to achieve rapid results, resulting in poor patient compliance and unsatisfactory treatment effects. The incidence of halitosis and dry mouth has increased significantly compared with the past. Observations have found that this is closely related to the common dietary preferences and living habits of the current population. The etiology and pathogenesis of this disease are mostly affected by lifestyle habits such as preference for spicy and stimulating diets, staying up late and lack of sleep, which lead to spleen and stomach yin deficiency and fire, and turbid qi. Compared with the prior art, the Chinese medicine composition of the present invention has the effects of nourishing yin and clearing heat, removing turbidity and removing odor, and is more targeted at the common causes and pathogenesis of halitosis and dry mouth. It is suitable for treating halitosis and dry mouth symptoms caused by various diseases in the form of oral administration and gargling. It has a rapid onset of action and significant therapeutic effect. It does not affect normal work and life during medication, and is safe and has no toxic side effects. Summary of the invention

[0005] In view of the problems existing in the prior art, the present invention provides a Chinese medicine composition for treating halitosis and dry mouth, and a preparation method and application thereof. The present invention is achieved through the following technical solutions:

[0006] The invention discloses a traditional Chinese medicine composition for treating halitosis and dry mouth, which comprises the following components: processed polygonatum, fresh dendrobium, capillaris, roasted loquat leaves, coptis root, uncaria, charred hawthorn, mint and bitter orange immature fruit.

[0007] As a further improvement, the present invention comprises the following components by weight: 15-50 parts of processed polygonatum, 15-50 parts of fresh dendrobium, 15-50 parts of capillaris, 15-50 parts of roasted loquat leaves, 6-15 parts of coptis chinensis, 6-20 parts of Uncaria rhynchophylla, 6-20 parts of charred hawthorn, 3-12 parts of mint, and 10-30 parts of bitter orange immature fruit.

[0008] As a further improvement, the present invention comprises the following components by weight: 30 parts of processed polygonatum, 30 parts of fresh dendrobium, 30 parts of capillaris, 30 parts of roasted loquat leaves, 9 parts of coptis chinensis, 12 parts of Uncaria rhynchophylla, 12 parts of charred hawthorn, 6 parts of mint, and 15 parts of bitter orange immature fruit.

[0009] The present invention also discloses a method for preparing a Chinese medicine composition, comprising the following steps:

[0010] 1) Add processed Polygonatum odoratum and fresh Dendrobium officinale into water, soak and boil, and obtain mixture A;

[0011] 2) adding Artemisia capillaris, roasted loquat leaves, Coptis chinensis, charred hawthorn, and fructus aurantii to mixture A, soaking and boiling to obtain mixture B;

[0012] 3) Add Uncaria rhynchophylla and Mentha chinensis to mixture B and boil them, and collect the decoction by filtering to obtain mixture C;

[0013] 4) Take a portion of mixture C to make mixture D, filter it, add sodium chloride to boil, and mix it with purified water to obtain Chinese herbal mouthwash D.

[0014] As a further improvement, the amount of water used in step 1) of the present invention is 5-10 times the total mass of the added processed polygonatum, fresh dendrobium, capillaris, roasted loquat leaves, coptis, Uncaria rhynchophylla, charred hawthorn, mint, and bran aurantium, the soaking time is 10-30 minutes, and the decoction time is 20-40 minutes.

[0015] As a further improvement, the decocting time in step 2) of the present invention is 20-40 minutes.

[0016] As a further improvement, the decocting time in step 3) of the present invention is 3-5 minutes.

[0017] As a further improvement, in step 4) of the present invention, the amount of the mixture D taken is 30-50 ml, the amount of sodium chloride used is 0.81-1.35 g, the decoction time is 5-10 min, and the ratio of the mixture D to the purified water is 1:2.

[0018] The invention also discloses the use of a traditional Chinese medicine composition in preparing a medicine for treating or alleviating halitosis and dry mouth.

[0019] The pharmacological effects of the Chinese medicine contained in the present invention are as follows:

[0020] Prepared Polygonatum odoratum: sweet in taste; slightly cold in nature. Enters the lung and stomach meridians. Efficacy: nourishes yin and moistens dryness, nourishes yin and produces body fluid. Mainly used to treat lung yin deficiency, dry heat cough, stomach yin deficiency, dry throat and thirst, internal heat and thirst, etc.

[0021] Fresh Dendrobium: sweet; slightly cold in nature. Enters the stomach and kidney meridians. Efficacy: nourishes the stomach and produces fluid, nourishes yin and clears heat. Indications: damage to body fluid due to febrile disease, dry mouth and thirst, insufficient stomach yin, poor appetite and retching, persistent fever after illness, kidney yin deficiency, blurred vision, yin deficiency and excessive fire, etc.

[0022] Artemisia capillaris: bitter and pungent; slightly cold in nature. Enters the spleen, stomach, liver and gallbladder meridians. Efficacy: clears away heat and dampness, promotes bile secretion and reduces jaundice. Indications: jaundice, oliguria, damp-heat and summer-heat, eczema and itching, etc.

[0023] Roasted loquat leaves: bitter; slightly cold in nature. Enter the lung and stomach meridians. Efficacy: clears the lungs and stops cough, lowers adverse qi and stops vomiting. It is mainly used to treat lung heat cough, qi reverse and shortness of breath, stomach heat vomiting, hiccups, irritability and thirst, etc.

[0024] Coptis chinensis: bitter in taste; cold in nature. Enters the heart, spleen, stomach, liver, gallbladder, and large intestine meridians. Efficacy: clears away heat and dampness, purges fire and detoxifies. Indications: damp-heat fullness, vomiting, diarrhea, high fever and coma, hyperactivity of heart fire, restlessness and insomnia, palpitations, vomiting and bleeding due to blood heat, vomiting and acid regurgitation due to stomach heat, thirst, toothache due to stomach fire, carbuncle, swelling and pain in the eyes, sores in the mouth and tongue, etc.

[0025] Uncaria rhynchophylla: sweet in taste; cool in nature. Enters the liver and pericardium meridians. Efficacy: calms wind and calms convulsions, clears heat and soothes the liver. Indications: internal movement of liver wind, convulsions due to epilepsy, high fever convulsions, headache and dizziness, colds with convulsions, crying of children, etc.

[0026] Scorched Hawthorn: sour and sweet; warm in nature. Enters the spleen, stomach, and liver meridians. Efficacy: helps digestion and strengthens the stomach, promotes qi and dissipates blood stasis, removes turbidity and reduces fat. It is mainly used to treat meat stagnation, stomach distension and pain, abdominal pain and diarrhea, diarrhea and abdominal pain, hernia pain, blood stasis, amenorrhea, dysmenorrhea, heart and abdomen stabbing pain, hyperlipidemia, etc.

[0027] Peppermint: pungent in taste; cool in nature. Enters the lung and liver meridians. Efficacy: dissipates wind-heat, clears the head and eyes, relieves sore throat, relieves rashes, soothes the liver and promotes qi. It is mainly used to treat wind-heat colds, early stage of febrile diseases, wind-heat attack, headache and dizziness, red eyes and tears, throat paralysis, sore throat, mouth and tongue sores, measles that do not break out, itchy urticaria, liver depression and qi stagnation, chest and flank distension, etc.

[0028] Fructus Aurantii Immaturus: bitter, pungent, sour; slightly cold in nature. Enters the spleen and stomach meridians. Efficacy: breaks up qi and eliminates stagnation, resolves phlegm and relieves lumps. Indications: stagnation of internal stagnation, fullness and pain, heaviness after diarrhea, constipation, phlegm blocking qi stagnation, chest pain, chest congestion, and sagging of organs.

[0029] The beneficial effects of the present invention are as follows:

[0030] A Chinese medicine composition for treating halitosis and dry mouth is developed based on the TCM principle of "treating both the symptoms and the root cause", combined with the etiology and pathogenesis characteristics of most current patients with halitosis and dry mouth, through exploring the country's rich TCM resources, combining existing pharmacodynamic research and a large amount of clinical experience, and through repeated experiments.

[0031] It is generally believed that the TCM etiology and pathogenesis of bad breath and dry mouth are spleen deficiency and dampness. However, it is observed in clinical practice that modern people have a rich variety of diets and obvious taste preferences. Many people prefer heavy-tasting, irritating (heavy oil, heavy salt, and heavy spicy) diets. Such diets are often spicy and irritating, and frying, roasting, and burning (burning refers to baking, frying, and burning refers to frying, frying, or drying food) often damage the yin of the spleen and stomach. In addition, the habit of staying up late and lack of sleep will cause more loss of yin fluid in the body. Bad breath and dry mouth are very common in people with such living habits. Therefore, it is believed that the etiology and pathogenesis of this disease are mostly caused by careless diet, which leads to damage to the yin fluid of the spleen and stomach, causing stomach fire to rise, turbid air to rise, and rushing to the mouth to cause bad breath. Insufficient yin fluid will cause dry mouth, which may be accompanied by bitter and greasy mouth, constipation, and toothache. Therefore, the present invention proposes to use "nourishing yin, clearing heat, removing turbidity and removing odor" as the treatment method on this basis, with large doses of processed Polygonatum odoratum and fresh Dendrobium as the main medicine, nourishing the yin of the spleen and stomach and clearing heat to guide fire downward, and with large doses of Artemisia capillaris and roasted loquat leaves as the ministerial medicines to remove turbidity and remove odor; Coptis chinensis clears heat and reduces fire, Citrus aurantium removes odor, and charred Crataegus pinnatifida, Uncaria rhynchophylla, and mint are aromatic and remove odor, which are adjuvant drugs. Compared with the traditional Chinese medicine treatment principle and treatment method, the method of "nourishing yin" combined with "removing odor" is highlighted, that is, nourishing the yin of the spleen and stomach to make the fire drop rapidly to treat the root cause, and combining the method of removing odor to treat the symptoms. It is found in clinical practice that the yin nourishing method and the deodorizing method are used together to take effect more quickly than the single use, and the cure rate is higher. In terms of specific medication, processed Polygonatum odoratum and fresh Dendrobium officinale (Yin-nourishing component) that nourish Yin and clear heat are selected as the main medicines, which are not used to treat bad breath in traditional Chinese medicine literature, and are used in large quantities, so that Yin fluid can be quickly restored, the fire of inflammation can be reduced, and the turbid air can be reduced accordingly. In addition, a large dose of Artemisia capillaris and roasted loquat leaves (deodorizing component) that have the effect of removing turbidity and odor can be used to quickly remove turbid air. The Yin-nourishing component and the deodorizing component work synergistically to improve the therapeutic effect of bad breath and dry mouth. Experiments have confirmed that the yin-nourishing components of processed polygonatum and fresh dendrobium in the composition, and the odor-removing components of capillaris and roasted loquat leaves also have a synergistic effect. Compared with the use of only one yin-nourishing medicine or one odor-removing medicine, the therapeutic effect is increased. The dosage of yin-nourishing components and odor-removing components accounts for nearly 70% of the entire composition. Assisted by coptis chinensis, uncaria rhynchophylla, charred hawthorn, mint, and bitter orange immature fruit, which can promote qi circulation, aromatize and remove turbidity, the combined effect is specific, and it is effective in treating bad breath and dry mouth caused by spleen and stomach yin deficiency, excessive fire, and upward flow of turbid qi.

[0032] Compared with the prior art, the Chinese medicine composition of the present invention is not only more targeted at the common causes and pathogenesis of halitosis and dry mouth, but also has the effects of nourishing yin and clearing heat, removing turbidity and removing odor through oral administration and gargling, treating both the symptoms and the root causes. The gargle can also inhibit local bacteria in the oral cavity, quickly improve the symptoms of halitosis and dry mouth, and simultaneously treat the main symptoms such as bitter taste in the mouth and sticky and uncomfortable mouth. It is easy to use, improves symptoms quickly, has significant therapeutic effects, is safe and has no toxic side effects, is convenient for patients to use in daily life, and improves the quality of life of patients. DETAILED DESCRIPTION

[0033] The invention discloses a traditional Chinese medicine composition for treating halitosis and dry mouth, which comprises the following components: processed polygonatum, fresh dendrobium, capillaris, roasted loquat leaves, coptis root, uncaria, charred hawthorn, mint and bitter orange immature fruit.

[0034] The invention comprises the following components by weight: 15-50 parts of processed polygonatum, 15-50 parts of fresh dendrobium, 15-50 parts of wormwood, 15-50 parts of roasted loquat leaves, 6-15 parts of coptis root, 6-20 parts of uncaria, 6-20 parts of charred hawthorn, 3-12 parts of mint and 10-30 parts of bitter orange immature fruit.

[0035] Preferably, the present invention comprises the following components by weight: 30 parts of processed polygonatum, 30 parts of fresh dendrobium, 30 parts of capillaris, 30 parts of roasted loquat leaves, 9 parts of coptis chinensis, 12 parts of Uncaria rhynchophylla, 12 parts of charred hawthorn, 6 parts of mint, and 15 parts of bitter orange immature fruit.

[0036] The present invention also discloses a method for preparing a Chinese medicine composition, comprising the following steps:

[0037] 1) Add processed polygonatum and fresh dendrobium to water for soaking and decoction to obtain mixture A; the amount of water is 5-10 times the total weight of the processed polygonatum, fresh dendrobium, capillaris, roasted loquat leaves, coptis root, Uncaria rhynchophylla, charred hawthorn, mint, and bran aurantium immaturum, the soaking time is 10-30 minutes, and the decoction time is 20-40 minutes.

[0038] 2) Add Artemisia capillaris, roasted loquat leaves, Coptis chinensis, charred hawthorn, and fructus aurantii to mixture A, soak and boil, and obtain mixture B; the boiling time is 20-40 minutes;

[0039] 3) Add Uncaria rhynchophylla and Mentha chinensis to mixture B and boil them, and collect the decoction by filtering to obtain mixture C; the boiling time is 3-5 minutes.

[0040] 4) Take a portion of mixture C to obtain mixture D, filter it, add sodium chloride to boil, and mix it with purified water to obtain Chinese medicine mouthwash D. The amount of mixture D is 30-50 ml, the amount of sodium chloride used is 0.81-1.35 g, the boiling time is 5-10 min, and the ratio of mixture D to purified water is 1:2.

[0041] The invention also discloses the use of a traditional Chinese medicine composition in preparing a medicine for treating or alleviating halitosis and dry mouth.

[0042] The present invention will be further described below in conjunction with specific embodiments so that those skilled in the art can better understand the present invention, but the present invention is not limited thereby.

[0043] Example 1

[0044] The present embodiment relates to a traditional Chinese medicine composition for improving bad breath, the effective ingredients of which are prepared from the following raw materials by weight: 30g of processed polygonatum, 30g of fresh dendrobium, 30g of capillaris, 30g of roasted loquat leaves, 9g of coptis chinensis, 12g of Uncaria rhynchophylla, 12g of charred hawthorn, 6g of mint, and 15g of fructus aurantii immaturus.

[0045] The preparation method of the above-mentioned Chinese medicine composition for improving halitosis and dry mouth comprises the following steps:

[0046] 1) Add processed Polygonatum odoratum and fresh Dendrobium officinale into 1200 ml of water, soak for 10 min, and boil for 20 min to obtain mixture A;

[0047] 2) Add Artemisia capillaris, roasted loquat leaves, Coptis chinensis, charred hawthorn, and fructus aurantii to mixture A, soak and boil for 30 minutes to obtain mixture B;

[0048] 3) Add Uncaria rhynchophylla and mint to mixture B and boil for 5 minutes. Filter and collect the decoction to obtain about 400 ml of mixture C;

[0049] 4) Take 50 ml of mixture C as mixture D, filter it, add 1.35 g of sodium chloride and boil for 10 min. After cooling, mix it with 100 ml of purified water to obtain 150 ml of Chinese herbal mouthwash D.

[0050] Example 2

[0051] The present embodiment relates to a traditional Chinese medicine composition for improving bad breath, the effective ingredients of which are prepared from the following raw materials by weight: 24g of processed polygonatum, 24g of fresh dendrobium, 24g of capillaris, 24g of roasted loquat leaves, 6g of coptis chinensis, 10g of Uncaria rhynchophylla, 10g of charred hawthorn, 5g of mint, and 12g of fructus aurantii.

[0052] The preparation method of the above-mentioned Chinese medicine composition for improving halitosis and dry mouth comprises the following steps:

[0053] 1) Add processed Polygonatum odoratum and fresh Dendrobium officinale into 1000 ml of water, soak for 10 minutes, and boil for 30 minutes to obtain mixture A;

[0054] 2) Add Artemisia capillaris, roasted loquat leaves, Coptis chinensis, charred hawthorn, and fructus aurantii to mixture A, soak and boil for 30 minutes to obtain mixture B;

[0055] 3) Add Uncaria rhynchophylla and mint to mixture B and boil for 5 minutes. Filter and collect the decoction to obtain about 350 ml of mixture C;

[0056] 4) Take 30 ml of mixture C as mixture D, filter it, add 0.81 g of sodium chloride and boil for 10 min. After cooling, mix it with 60 ml of purified water to obtain 90 ml of Chinese herbal mouthwash D.

[0057] Example 3

[0058] The present embodiment relates to a traditional Chinese medicine composition for improving bad breath, the effective ingredients of which are prepared from the following raw materials by weight: 30g of processed polygonatum, 30g of fresh dendrobium, 30g of capillaris, 30g of roasted loquat leaves, 9g of coptis chinensis, 12g of Uncaria rhynchophylla, 12g of charred hawthorn, 6g of mint, and 15g of fructus aurantii immaturus.

[0059] The preparation method of the above-mentioned Chinese medicine composition for improving halitosis and dry mouth comprises the following steps:

[0060] 1) Add processed Polygonatum odoratum and fresh Dendrobium officinale into 1200 ml of water, soak for 10 min, and boil for 20 min to obtain mixture A;

[0061] 2) Add Artemisia capillaris, roasted loquat leaves, Coptis chinensis, charred hawthorn, and fructus aurantii to mixture A, soak and boil for 20 minutes to obtain mixture B;

[0062] 3) Add Uncaria rhynchophylla and mint to mixture B and boil for 3 minutes. Filter and collect the decoction to obtain about 400 ml of mixture C;

[0063] 4) Take 50 ml of mixture C as mixture D, filter it, add 1.35 g of sodium chloride and boil for 10 min. After cooling, mix it with 100 ml of purified water to obtain 150 ml of Chinese herbal mouthwash D.

[0064] Comparative Example 1

[0065] In this comparative example, the drugs in Example 1 were adjusted as follows: processed Polygonatum odoratum and fresh Dendrobium officinale were removed, and the remaining drugs and preparation methods were the same as those in Example 1.

[0066] Comparative Example 2

[0067] In this comparative example, the drugs in Example 1 are adjusted as follows: processed Polygonatum odoratum is removed, and the remaining drugs and preparation methods are the same as those in Example 1.

[0068] Comparative Example 3

[0069] In this comparative example, the drugs in Example 1 were adjusted as follows: fresh dendrobium was removed, and the remaining drugs and preparation methods were the same as those in Example 1.

[0070] Comparative Example 4

[0071] In this comparative example, the drugs in Example 1 were adjusted as follows: Artemisia capillaris and roasted loquat leaves were removed, and the remaining drugs and preparation methods were the same as those in Example 1.

[0072] Comparative Example 5

[0073] In this comparative example, the drugs in Example 1 are adjusted as follows: Artemisia capillaris is removed, and the remaining drugs and preparation methods are the same as those in Example 1.

[0074] Comparative Example 6

[0075] In this comparative example, the drugs in Example 1 were adjusted as follows: the roasted loquat leaves were removed, and the remaining drugs and preparation methods were the same as those in Example 1.

[0076] The beneficial effects of the present invention are further illustrated below in conjunction with typical cases in practice.

[0077] 1. Diagnostic Criteria

[0078] The nasal sniffing method is used to detect bad breath: the examiner and the subject face each other, about 10 cm away. The subject closes his mouth and breathes through the nose for 1 minute, then opens his mouth and exhales gently. If the examiner smells obvious bad breath, it is confirmed that bad breath occurs.

[0079] A subjective method is used to judge dry mouth: dry mouth is confirmed if there is a chief complaint of "dry mouth" or "thirst".

[0080] According to the Rosenberg scoring system recommended by the 1999 International Symposium on Halitosis, the degree of halitosis is divided into three degrees:

[0081] Mild halitosis: Mild halitosis, with a peculiar smell, but very slight;

[0082] Moderate halitosis: noticeable bad breath;

[0083] Severe halitosis: Severe halitosis but the examiner can still tolerate it, or even a strong stench that the examiner cannot tolerate.

[0084] II. Exclusion criteria

[0085] a. Patients with organic diseases of the digestive tract such as gastric ulcer and gastric cancer diagnosed by gastroscopy or barium radioscopy;

[0086] b. Check patients with oral diseases such as periodontitis and dental caries in the Department of Stomatology;

[0087] c. Accompanied by systemic diseases or serious organ diseases, such as diabetes, liver cirrhosis, uremia, malignant tumors, etc.;

[0088] d. Anyone who has smoked, drunk, or consumed food or medicine with strong odor within the past month.

[0089] III. Inclusion Criteria

[0090] a. Those who meet the diagnostic criteria of "bad breath" and "dry mouth" at the same time, and do not meet any of the exclusion criteria;

[0091] b. Aged 18-60;

[0092] c. Those who voluntarily cooperate in the trial and provide informed consent.

[0093] IV. Clinical Data

[0094] According to the inclusion criteria, 64 qualified cases were randomly divided into 8 groups (8 cases in the treatment group, 8 cases in comparison group 1, comparison group 2, comparison group 3, comparison group 4, comparison group 5, comparison group 6, and 8 cases in each group), and there were no significant differences in gender, age, disease course, and lesion severity among the 8 groups, and they were comparable.

[0095] 5. Treatment Methods

[0096] The treatment group orally took the Chinese medicine composition prepared in Example 1, 2 times / day, about 175 ml each time, and gargled with a Chinese medicine mouthwash, 50 ml each after each meal in the morning, noon and evening, and gargled for 30 seconds each time. The comparative example 1 group, the comparative example 2 group, the comparative example 3 group, the comparative example 4 group, the comparative example 5 group, and the comparative example 6 group took the Chinese medicine composition of each group orally, 2 times / day, about 175 ml each time, and gargled with the Chinese medicine mouthwash of each group, 50 ml each after each meal in the morning, noon and evening, and gargled for 30 seconds each time. The control group took the following Chinese medicine composition orally: 9g ​​of dried tangerine peel, 3g of costusroot, 12g of stir-fried codonopsis, 12g of stir-fried atractylodes, 9g of tuckahoe, 6g of liquorice, 3g of amomum villosum, 9g of pinellia tuber, 9g of patchouli, and 9g of perilla, decocted to obtain 350ml of Chinese medicine decoction, twice a day, 175ml each time, and gargled with normal saline, 50ml each after each meal in the morning, noon and evening, gargling for 30s each time. The course of treatment was 2 weeks.

[0097] VI. Efficacy Standards

[0098] Basically cured: Bad breath and dry mouth symptoms disappeared;

[0099] Effective: Bad breath symptoms are reduced by at least one level and dry mouth symptoms are alleviated;

[0100] Ineffective: Bad breath symptoms are reduced by less than one level or dry mouth symptoms are not significantly improved.

[0101] VII. Treatment Outcomes

[0102] The results of the comparison of the efficacy among the six groups are shown in Table 1.

[0103] Table 1

[0104] Group Number of cases Almost recovered efficient invalid Effectiveness (%) Basic recovery rate (%) Treatment Group 8 4 4 0 100% 50% Comparative Example 1 8 1 5 2 75% 12.5% Comparative Example 2 8 1 5 2 75% 12.5% Comparative Example 3 8 1 6 1 87.5% 12.5% Comparative Example 4 8 2 5 1 87.5% 25% Comparative Example 5 8 3 4 1 87.5% 37.5% Comparative Example 6 8 3 4 1 87.5% 37.5% Control group 8 1 4 3 62.5% 12.5%

[0105] It can be seen from Table 1 that compared with the control group, the treatment group and each comparative group have higher therapeutic efficacy and basic cure rate, among which the treatment group has the highest efficacy and basic cure rate. In the clinical observation test, the efficacy is 100%, indicating that the Chinese medicine composition prepared in Example 1 can significantly improve the symptoms of halitosis and dry mouth, and has a definite therapeutic effect.

[0106] Compared with the treatment group, after removing the yin nourishing component (group 1 of comparison example) or removing the deodorizing component (group 4 of comparison example), the effective rate and basic cure rate of the treatment were significantly reduced (the effective rate of group 1 of comparison example decreased by 25%, and the group 4 of comparison example decreased by 12.5%; the basic cure rate of group 1 of comparison example decreased by 37.5%, and the group 4 of comparison example decreased by 25%). It can be seen that the yin nourishing component (processed Polygonatum odoratum, fresh Dendrobium) and the deodorizing component (Artemisia capillaris, roasted loquat leaf) in the present invention have a synergistic effect, and are indispensable in the treatment process. Among them, the yin nourishing component is more important for treating the symptoms of bad breath and dry mouth. The average effective rate of group 1, group 2, and group 3 of comparison example, which remove all or a single yin nourishing component, is 79.2%, and the average basic cure rate is 12.5%, which are all lower than 87.5% and 33.3% of group 4, group 5, and group 6 of comparison example, which remove all or a single deodorizing component.

[0107] Compared with the treatment group and the comparative example 1 group, the comparative example 2 group, and the comparative example 3 group, after using only a single yin nourishing component (processed yuzhu or fresh dendrobium), the effective rate of treatment and the basic cure rate also decreased, indicating that there is also a synergistic effect between the yin nourishing components, among which the therapeutic effect of processed yuzhu is stronger. Similarly, there is also a synergistic effect between the deodorizing components. The therapeutic effect of the yin nourishing component and the deodorizing component according to the mass ratio of the present invention is the best, and the yin nourishing component (processed yuzhu, fresh dendrobium) and the deodorizing component (artemisia capillaris, roasted loquat leaf) account for about 70% of the entire composition.

[0108] No obvious adverse reactions were observed in each group before and after treatment.

[0109] In order to further verify the therapeutic effect of the present invention, a product antibacterial test was also conducted.

[0110] Three patients with severe halitosis and dry mouth were randomly selected from the above inclusion criteria, and cotton swabs were used to wipe the inner walls of both sides of their mouths and tongue coating for sampling. The three sampling cotton swabs were immersed in beef extract peptone liquid culture medium and cultured at 37°C for 12 hours to obtain a mixed bacterial solution.

[0111] The experiment was conducted in 9 groups (treatment group, comparative example 1 group, comparative example 2 group, comparative example 3 group, comparative example 4 group, comparative example 5 group, comparative example 6 group, control group, blank group). The mixed bacterial solution was diluted 100 times with distilled water to 1350 ml, and after sufficient mixing, it was randomly divided into 9 groups, 3 tubes in each group, and 50 ml of diluted mixed bacterial solution in each tube. The treatment group added 10 ml of the Chinese medicine mouthwash of Example 1, the comparative example 1 group, the comparative example 2 group, the comparative example 3 group, the comparative example 4 group, the comparative example 5 group, and the comparative example 6 group respectively added 10 ml of the Chinese medicine mouthwash obtained in each group, the control group added 10 ml of physiological saline, and the blank group added 10 ml of distilled water. After sufficient mixing, it was evenly coated on beef extract peptone solid culture medium, and the colony count was performed after culturing at 37°C for 12 hours. The colony counts of 3 solid culture bacteria in each group were counted separately, and the average value was taken. The statistical results are shown in Table 2.

[0112] Table 2

[0113] Group Number of colonies Antibacterial rate (%, compared with the blank group) Treatment Group 7.3 91.6% Comparative Example 1 13.3 84.7% Comparative Example 2 9.7 88.9% Comparative Example 3 11.3 87.0% Comparative Example 4 16.7 80.9% Comparative Example 5 15.3 82.4% Comparative Example 6 14.7 83.2% Control group 42.3 51.5% Blank Group 87.3 0%

[0114] It can be seen from Table 2 that the antibacterial rates of the treatment group and each comparative group are significantly higher than those of the control group, indicating that the Chinese medicine compositions prepared in Example 1 and each comparative group can inhibit local oral bacteria, all of which are higher than the normal saline control group by more than 30%. Among them, the Chinese medicine composition of Example 1 has the best effect, with the highest antibacterial rate of more than 90%, indicating that the local antibacterial therapeutic effect of the Chinese medicine mouthwash prepared in Example 1 is definite. Compared with the treatment group, each comparative group has a decrease in the antibacterial rate after removing the yin nourishing component (Comparative Example 1 Group) or removing the deodorizing component (Comparative Example 4 Group) (the ratio 1 group decreased by 6.9%, and the comparison group 4 group decreased by 9.0%). It can be seen that the yin nourishing component (processed Polygonatum odoratum, fresh Dendrobium) and the deodorizing component (Artemisia capillaris, roasted loquat leaves) in the present invention also have a synergistic effect in the process of local antibacterial, among which the deodorizing component has a stronger effect on local antibacterial, and the antibacterial effect decreases more significantly after removing the deodorizing component. The local antibacterial effect of the yin nourishing component and the odor removing component according to the mass ratio of the present invention is the best.

[0115] Case examples

[0116] The patient, a 36-year-old male, came to the hospital for halitosis and dry mouth for more than half a year. Halitosis appeared without obvious causes half a year ago, and symptoms such as dry mouth and bleeding gums gradually appeared. The rest had no obvious discomfort and did not seek medical treatment. Later, the symptoms persisted. Because the bad breath affected normal social interaction, he came to the outpatient clinic for treatment in November 2024. He had a good appetite, normal sleep, and a habit of staying up late to eat supper. His stool was slightly hard, and his urine was normal. Auxiliary examinations: Gastroscopy and oral examinations did not show abnormalities such as gastric ulcers, caries, and periodontitis. Physical examination: red tongue with yellow and greasy coating, cracks at the bottom, and deep pulse. Diagnosis: Yin deficiency and fire in the breath, turbid air rising. Treatment is to nourish yin and clear heat, and remove turbidity and odor. The prescription is to take one dose of the water decoction of the Chinese medicine composition of the present invention daily, about 400 ml, divided into two warm doses, about 175 ml each time, and 50 ml of the water decoction is filtered again with filter paper, and then 1.35 g of sodium chloride is added and boiled for 10 minutes. After cooling, 100 ml of pure water is added and mixed to obtain a mouthwash. The mouthwash is rinsed after three meals, 3 times / day, 50 ml each time. After taking the medicine for 1 month, the dosage of the raw materials of the Chinese medicine combination is adjusted according to clinical syndrome differentiation, and the symptoms of bad breath and dry mouth are basically cured, and normal social interaction is not affected.

[0117] The above detailed description is a specific description of a feasible embodiment of the present invention. The embodiment is not intended to limit the patent scope of the present invention. Any equivalent implementation or modification that does not deviate from the present invention should be included in the scope of the technical solution of the present invention.

Claims

1. A Chinese medicine composition for treating halitosis and dry mouth, characterized in that: The invention comprises the following components: processed polygonatum, fresh dendrobium, wormwood, roasted loquat leaf, coptis root, uncaria, charred hawthorn, mint and bitter orange immature fruit.

2. The Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following components by weight: 15-50 parts of processed polygonatum, 15-50 parts of fresh dendrobium, 15-50 parts of wormwood, 15-50 parts of roasted loquat leaves, 6-15 parts of coptis root, 6-20 parts of uncaria, 6-20 parts of charred hawthorn, 3-12 parts of mint and 10-30 parts of bitter orange immature fruit.

3. The Chinese medicine composition according to claim 2, characterized in that: The invention comprises the following components by weight: 30 parts of processed polygonatum, 30 parts of fresh dendrobium, 30 parts of wormwood, 30 parts of roasted loquat leaves, 9 parts of coptis root, 12 parts of uncaria, 12 parts of charred hawthorn, 6 parts of mint and 15 parts of bitter orange immature fruit.

4. A method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The steps include: 1) Add processed Polygonatum odoratum and fresh Dendrobium officinale into water, soak and boil, and obtain mixture A; 2) adding Artemisia capillaris, roasted loquat leaves, Coptis chinensis, charred hawthorn, and fructus aurantii to mixture A, soaking and boiling to obtain mixture B; 3) Add Uncaria rhynchophylla and Mentha chinensis to mixture B and boil them, and collect the decoction by filtering to obtain mixture C; 4) Take a portion of mixture C to make mixture D, filter it, add sodium chloride to boil, and mix it with purified water to obtain Chinese herbal mouthwash D.

5. The preparation method according to claim 4, characterized in that: The amount of water used in step 1) is 5-10 times the total mass of the processed polygonatum, fresh dendrobium, capillaris, roasted loquat leaves, coptis, Uncaria rhynchophylla, charred hawthorn, mint, and bran aurantium. The soaking time is 10-30 minutes, and the decoction time is 20-40 minutes.

6. The preparation method according to claim 4, characterized in that: The decoction time in step 2) is 20-40 minutes.

7. The preparation method according to claim 5 or 6, characterized in that: The decoction time in step 3) is 3-5 minutes.

8. The preparation method according to claim 7, characterized in that: In step 4), the amount of mixture D taken is 30-50 ml, the amount of sodium chloride used is 0.81-1.35 g, the decoction time is 5-10 min, and the ratio of mixture D to purified water is 1:

2.

9. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating or alleviating halitosis and dry mouth.