Traditional Chinese medicine composition for relieving xerostomia after drinking and application of traditional Chinese medicine composition

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly provides a traditional Chinese medicine composition for relieving xerostomia after drinking and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises a kudzuvine root extract, a codonopsis pilosula extract, an astragalus membranaceus extract and a mulberry leaf extract which are combined according to a corresponding specific proportion, and the composition is applied to a wine body and can remarkably relieve the dry mouth feeling after drinking.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine compositions, and in particular to a traditional Chinese medicine composition for relieving dry mouth after drinking and its application. Background Art

[0002] Dry mouth after drinking is a common feeling after drinking alcohol. It is a physiological demand response of the body to water, mainly triggered by changes in body fluid osmotic pressure, blood volume, and blood pressure. The generation mechanism has the following aspects: (1) After drinking alcohol, ethanol enters the blood, leading to an increase in serum osmotic pressure, directly stimulating the osmoreceptor and generating a thirst sensation. (2) Alcohol has a diuretic effect, inhibiting the secretion of antidiuretic hormone, increasing urine output and causing the body to lose water, thus resulting in dry mouth. (3) Alcohol stimulates adrenaline, accelerating metabolism and causing a large amount of water loss. Further dehydration will exacerbate dry mouth. (4) Alcohol inhibits the secretion of saliva, leading to dryness in the mouth and causing dry mouth. Among the above mechanisms, the dynamic change of serum osmotic pressure, as the core intersection point of ethanol concentration and body fluid loss, is highly correlated with the degree of dry mouth and is a key indicator for evaluating dry mouth after drinking. In addition, salivary flow rate is also an important indicator for evaluating the dry mouth condition of the body, which can objectively reflect the functional state of oral saliva secretion. When the salivary flow rate is significantly reduced, the decrease in saliva secretion will cause dryness and insufficient lubrication of the oral mucosa, thus triggering the symptoms of dry mouth.

[0003] Currently, traditional Chinese medicine has accumulated rich research in the study of post-drinking comfort such as relieving alcohol intoxication, and there are also many commercially available products. However, there are few reports on the intervention research of traditional Chinese medicine for immediate dry mouth after drinking. Summary of the Invention

[0004] In view of this, the present invention provides a traditional Chinese medicine composition capable of relieving dry mouth after drinking.

[0005] The technical solution of the present invention is realized as follows: The present invention provides a traditional Chinese medicine composition for relieving dry mouth after drinking, comprising the following components in parts by weight: 5 - 50 parts of pueraria lobata extract, 5 - 50 parts of codonopsis pilosula extract, 20 - 65 parts of astragalus membranaceus extract, and 10 - 40 parts of mulberry leaf extract.

[0006] In some embodiments, it comprises the following components in parts by weight: 12 parts of pueraria lobata extract, 12 parts of codonopsis pilosula extract, 50 parts of astragalus membranaceus extract, and 26 parts of mulberry leaf extract.

[0007] In some embodiments, it comprises the following components in parts by weight: 10 parts of pueraria lobata extract, 36 parts of codonopsis pilosula extract, 36 parts of astragalus membranaceus extract, and 18 parts of mulberry leaf extract.

[0008] In some embodiments, it comprises the following components in parts by weight: 36 parts of pueraria lobata extract, 10 parts of codonopsis pilosula extract, 36 parts of astragalus membranaceus extract, and 18 parts of mulberry leaf extract.

[0009] In some embodiments, the method for preparing the kudzu root extract comprises: pulverizing the kudzu root, extracting with 90% ethanol, concentrating, acid hydrolyzing, purifying with resin, concentrating, crystallizing, recrystallizing, drying, and pulverizing to obtain the extract. The mass content of puerarin in the kudzu root extract is ≥80%.

[0010] In some embodiments, the method for preparing the codonopsis pilosula extract comprises: pulverizing the codonopsis pilosula, extracting with 60% ethanol, and concentrating and drying to obtain the extract. The mass content of polysaccharide in the codonopsis pilosula extract is ≥20%.

[0011] In some embodiments, the method for preparing the astragalus membranaceus extract comprises: pulverizing the astragalus membranaceus, extracting with alkaline water, separating with resin, collecting the 70% ethanol eluate, and concentrating and drying to obtain the extract. The mass content of astragaloside IV in the astragalus membranaceus extract is ≥15%.

[0012] In some embodiments, the method for preparing the mulberry leaf extract comprises: extracting the mulberry leaf with water, purifying with resin, concentrating, and drying to obtain the extract. The mass content of flavonoids in the mulberry leaf extract is ≥5%.

[0013] In the second aspect of the present invention, there is also provided an application of the above-mentioned traditional Chinese medicine composition for relieving dry mouth after drinking, which is used for adding to the wine body to relieve dry mouth after drinking.

[0014] In some embodiments, the addition amount of the traditional Chinese medicine composition in the wine body is 300 - 500 mg / L.

[0015] In some embodiments, the alcohol content range of the wine body should be between 15 and 65 degrees.

[0016] Kudzu root is the dried root of Pueraria lobata (Willd.) Ohwi, which tastes sweet, pungent, and cool, and has the effects of relieving muscle fever, promoting fluid production to quench thirst, lifting yang to stop diarrhea, and detoxifying alcohol. It is also recorded in "Shennong's Herbal Classic" that "kudzu root is mainly used for treating thirst, high fever, vomiting, various arthralgias, promoting the production of yin qi, and detoxifying various poisons". Its effects of relieving alcohol and dry mouth after drinking mainly benefit from its active ingredients puerarin and flavonoid compounds. Puerarin and flavonoid compounds can accelerate the metabolism of alcohol in the liver, reduce the residence time of alcohol in the body, and thus alleviate the symptoms of drunkenness after drinking. At the same time, certain components in kudzu root can also inhibit the absorption of alcohol by the gastrointestinal tract and reduce the speed of alcohol entering the blood.

[0017] Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. is the dried root of the leguminous plant. It tastes sweet and slightly warm, and has the effects of invigorating qi and lifting yang, benefiting qi and strengthening the superficial resistance, promoting diuresis and alleviating edema, promoting the production of body fluid and nourishing blood, promoting qi circulation to relieve pain, expelling pus by supporting healthy qi, etc. Astragalus membranaceus has a hepatoprotective effect, can enhance the detoxification ability of the liver, help accelerate alcohol metabolism, and reduce the residence time of alcohol in the body. At the same time, Astragalus membranaceus has a diuretic effect, which can help accelerate the excretion of alcohol through urine, thereby alleviating discomfort symptoms after drinking, such as dry mouth and headache after drinking.

[0018] Codonopsis pilosula (Franch.) Nannf., Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen or Codonopsis tangshen Oliv. is the dried root of the campanulaceous plant. It tastes sweet and is flat. It has the effects of invigorating the spleen and benefiting the lungs, nourishing blood and promoting the production of body fluid. Codonopsis pilosula can enhance blood circulation and help the body better distribute water.

[0019] Mulberry leaf is the dried leaf of the mulberry plant. It tastes sweet, bitter and cold. It has the effects of dispersing wind-heat, moistening the lung and relieving dryness, suppressing hyperactive liver-yang, clearing the liver and improving eyesight, etc. Mulberry leaf has the effect of clearing heat and detoxifying, which can help relieve discomfort symptoms such as dry mouth and headache after drinking. In addition, the flavonoid components in mulberry leaf may help accelerate the metabolism of alcohol in the liver and reduce the residence time of alcohol in the body.

[0020] The present invention has the following beneficial effects compared with the prior art:

[0021] The traditional Chinese medicine composition of the present invention is novel, and the raw material medicinal materials such as Pueraria lobata, Astragalus membranaceus, Codonopsis pilosula, and mulberry leaf are all first applied to the research on dry mouth after drinking.

[0022] The traditional Chinese medicine composition of the present invention significantly alleviates the feeling of dry mouth after drinking by down-regulating the serum osmotic pressure after drinking and increasing the oral saliva flow rate.

[0023] The Chinese medicinal materials used in the traditional Chinese medicine composition of the present invention all belong to the category of homologous medicines and foods, and have high safety.

[0024] The extraction process of the traditional Chinese medicine composition of the present invention is conventional, and the process does not involve special or complex process steps, and is easy to realize industrial production. Detailed implementation mode

[0025] Next, in combination with the implementation mode of the present invention, the technical solutions in the implementation mode of the present invention will be clearly and completely described. Obviously, the described implementation mode is only a part of the implementation modes of the present invention, rather than all of the implementation modes. Based on the implementation modes in the present invention, all other implementation modes obtained by those of ordinary skill in the art without creative work fall within the protection scope of the present invention.

[0026] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the embodiments of the present invention belong. If the definitions stated in this section are contrary to or inconsistent with the definitions stated in the patents, patent applications, published patent applications, and other publications incorporated herein by reference, the definitions listed in this section shall prevail over the definitions incorporated herein by reference.

[0027] Unless otherwise specified, the methods used in the following examples are all conventional methods. The materials, reagents, and instruments used, unless otherwise specified, are all conventional materials, reagents, and instruments in the art, and can be obtained by those skilled in the art through commercial channels.

[0028] When an equivalent, concentration, or other value or parameter is expressed as a range, a preferred range, or a range defined by a series of upper preferred values and lower preferred values, it should be understood that all ranges formed by any pairing of any range upper limit or preferred value with any range lower limit or preferred value are specifically disclosed, regardless of whether the ranges are separately disclosed. For example, when the range "1 to 5" is disclosed, the described range should be interpreted as including the ranges "1 to 4", "1 to 3", "1 to 2", "1 to 2 and 4 to 5", "1 to 3 and 5", etc. When a numerical range is described herein, unless otherwise stated, the range is intended to include its end values and all integers and fractions within the range. In the specification and claims of this application, range limitations can be combined and / or interchanged, and these ranges include all sub-ranges contained therein unless otherwise stated.

[0029] Preparation Example 1

[0030] Preparation of Pueraria lobata extract:

[0031] Raw material treatment: Take dried Pueraria lobata and crush it to 20 mesh, add 90% ethanol according to a solid-liquid ratio of 1:10, reflux and extract 3 times at 85°C for 1 hour each time, and combine the filtrates.

[0032] Acid hydrolysis: Concentrate the filtrate until there is no ethanol, add 1-2% sulfuric acid solution (pH 1.5-3.0), hydrolyze at 80°C for 2 hours, neutralize to pH 6.5 and then filter.

[0033] Resin purification: Pass the hydrolyzate through an AB-8 or D101 macroporous resin column, wash off impurities with 3 column volumes of hydrochloric acid solution with pH = 2, and then elute the target component with 5 column volumes of 70% ethanol, and collect the eluate.

[0034] Crystallization and drying: Concentrate the eluate under reduced pressure to a relative density of 1.10-1.15, crystallize at 4°C, and after recrystallization, spray dry (inlet temperature 180°C) to obtain a solid powder. After detection by high performance liquid chromatography, the puerarin content is ≥80%.

[0035] Preparation of Astragalus membranaceus extract:

[0036] Alkaline extraction process: After the Astragalus membranaceus medicinal materials are pulverized, add NaOH solution with a pH of 8 - 9 according to a solid - liquid ratio of 1:10, stir and extract at 80 °C for 2 times, 1.5 hours each time, and combine the filtrates.

[0037] Resin treatment: The filtrate passes through HPD - 100 macroporous resin, is washed with water, and then eluted with 70% ethanol (flow rate 2BV / h), and the eluate is collected.

[0038] Concentration and purification: The eluate is concentrated under reduced pressure to a paste - like state, added with 3 times the amount of 95% ethanol for alcohol precipitation, allowed to stand for 24 hours and then centrifuged, and the precipitate is vacuum - dried at 60 °C to obtain a solid powder. After detection by high - performance liquid chromatography, the content of astragaloside IV is ≥15%.

[0039] Preparation of Codonopsis pilosula extract:

[0040] Pretreatment: The crude powder of Codonopsis pilosula is reflux - extracted with 5 times the amount of 70% ethanol for 2 times (45 minutes each time), the filtrate is concentrated and then loaded onto a D101 macroporous resin column, and impurities are removed by water elution.

[0041] Enzymatic hydrolysis optimization: The filter residue is added with water according to a solid - liquid ratio of 1:6, the pH is adjusted to 4.5 with acetic acid, 0.1% cellulase and pectinase are added, and enzymatic hydrolysis is carried out at 45 °C for 1 hour. After boiling to inactivate the enzyme, it is centrifuged.

[0042] Polysaccharide purification: The supernatant is added with 75% ethanol for alcohol precipitation, allowed to stand for 3 hours and then centrifuged, and the precipitate is freeze - dried to obtain a solid powder. After detection by high - performance liquid chromatography, the content of Codonopsis pilosula polysaccharide is ≥20%.

[0043] Preparation of Morus alba leaf extract:

[0044] Water extraction process: The fresh Morus alba leaves are chopped and added with water according to a solid - liquid ratio of 1:10, decocted at 95 °C for 3 times (1 hour each time), and the combined filtrate is passed through a 0.22 - μm microporous membrane.

[0045] Resin enrichment: The filtrate passes through an AB - 8 macroporous resin column, impurities are eluted successively with 2BV of water and 3BV of 50% ethanol, and finally flavonoid components are eluted with 5BV of 70% ethanol.

[0046] Concentration and drying: The flavonoid eluate is concentrated under reduced pressure to a relative density of 1.12 and spray - dried (inlet temperature 170 °C) to obtain a solid powder. After detection by high - performance liquid chromatography, the content of Morus alba leaf flavonoids is ≥5%.

[0047] Example 1

[0048] This example provides a traditional Chinese medicine composition for relieving dry mouth after drinking. The traditional Chinese medicine composition includes four extracts of Pueraria lobata, Codonopsis pilosula, Astragalus membranaceus, and Morus alba leaf, which are combined in a ratio of 12:12:50:26 and mixed evenly.

[0049] Example 2

[0050] This example provides a traditional Chinese medicine composition for relieving dry mouth after drinking. The traditional Chinese medicine composition includes four extracts of Pueraria lobata, Codonopsis pilosula, Astragalus membranaceus, and Morus alba. They are combined in a ratio of 10:36:36:18 and mixed evenly.

[0051] Example 3

[0052] This example provides a traditional Chinese medicine composition for relieving dry mouth after drinking. The traditional Chinese medicine composition includes four extracts of Pueraria lobata, Codonopsis pilosula, Astragalus membranaceus, and Morus alba. They are combined in a ratio of 36:10:36:18 and mixed evenly.

[0053] The traditional Chinese medicine compositions in each example are added to the 42-degree edible alcohol body at a dose of 400 mg / L. At the same time, 42-degree edible alcohol is set as the control group. A comparative study on the degree of dry mouth after drinking in mice is carried out through serum osmotic pressure detection, and the serum osmotic pressure values of each test group 1 hour after drinking are detected. And the verification of dry mouth after drinking in the population is carried out by saliva flow rate detection, and the saliva flow rate of each test group 0.5 hour after drinking is detected. The specific analysis of the data analysis results is shown in Table 1.

[0054] Table 1: Serum osmotic pressure values of mice and saliva flow rates of the population in each of Examples 1-3

[0055] Group Mouse serum osmotic pressure value Human saliva flow rate 42-degree edible alcohol group 465.2±12.6 1.13±0.58 42-degree liquor body added with the composition of Example 1 419.7±7.2*** 1.64±0.53# 42-degree liquor body added with the composition of Example 2 428.0±2.8** 1.51±0.59# 42-degree liquor body added with the composition of Example 3 420.0±11.0** 1.52±0.67#

[0056] Note: Compared with the "42-degree edible alcohol" group, "*" means p < 0.05; "**" means p < 0.01; "***" means p < 0.001; compared with the "42-degree edible alcohol" group, "#" means p < 0.05; "##" means p < 0.01; "" means p < 0.001.

[0057] The data in Table 1 show that when the traditional Chinese medicine composition provided by the present invention is added to the 42-degree edible alcohol body at the corresponding dose, it can significantly relieve the degree of dry mouth after drinking of the original 42-degree edible alcohol body. Specifically, it is manifested as significantly down-regulating the serum osmotic pressure value of mice 1 hour after drinking and significantly up-regulating the saliva flow rate of the population 0.5 hour after drinking.

[0058] Comparative Example 1

[0059] Compared with Example 1, the difference is that the traditional Chinese medicine composition of Comparative Example 1 lacks Pueraria lobata extract, and the composition ratio changes. The combined ratio of the extracts of Codonopsis pilosula, Astragalus membranaceus, and Morus alba is 14:56:30. The traditional Chinese medicine composition after lacking Pueraria lobata extract is added to the 42-degree edible alcohol body at a dose of 400 mg / L, and a comparative study on the degree of dry mouth after drinking is carried out.

[0060] Comparative Example 2

[0061] Compared with Example 1, the difference is that the traditional Chinese medicine composition of Comparative Example 2 lacks Codonopsis pilosula extract, and the combined ratio changes accordingly. The combined ratio of the extracts of Pueraria lobata, Astragalus membranaceus, and Morus alba is 14:56:30. The traditional Chinese medicine composition after lacking Codonopsis pilosula extract is added to the 42-degree edible alcohol body at a dose of 400 mg / L, and a comparative study on the degree of dry mouth after drinking is carried out.

[0062] Comparative Example 3

[0063] Compared with Example 1, the difference is that the traditional Chinese medicine composition of Comparative Example 3 lacks Astragalus membranaceus extract, and the combined ratio changes accordingly. The combined ratio of the extracts of Pueraria lobata, Codonopsis pilosula, and Morus alba is 24:24:52. The traditional Chinese medicine composition after lacking Astragalus membranaceus extract is added to the 42-degree edible alcohol body at a dose of 400 mg / L, and a comparative study on the degree of dry mouth after drinking is carried out.

[0064] Comparative Example 4

[0065] Compared with Example 1, the difference is that the traditional Chinese medicine composition of Comparative Example 4 lacks Morus alba extract, and the combined ratio changes accordingly. The combined ratio of the extracts of Pueraria lobata, Codonopsis pilosula, and Astragalus membranaceus is 16:16:68. The traditional Chinese medicine composition after lacking Morus alba extract is added to the 42-degree edible alcohol body at a dose of 400 mg / L, and a comparative study on the degree of dry mouth after drinking is carried out.

[0066] Comparative Example 5

[0067] Compared with Example 1, Comparative Example 5 only contains Pueraria lobata extract, and the single addition dose of Pueraria lobata extract is adjusted to 48 mg / L accordingly and added to the 42-degree edible alcohol body, and a comparative study on the degree of dry mouth after drinking is carried out.

[0068] Comparative Example 6

[0069] Compared with Example 1, Comparative Example 6 only contains Codonopsis pilosula extract, and the single addition dose of Codonopsis pilosula extract is adjusted to 48 mg / L accordingly and added to the 42-degree edible alcohol body, and a comparative study on the degree of dry mouth after drinking is carried out.

[0070] Comparative Example 7

[0071] Compared with Example 1, Comparative Example 7 only contains the astragalus extract, and the dosage of the single astragalus extract is adjusted accordingly to 200 mg / L and added to the 42-degree edible alcohol body to conduct a comparative study on the degree of dry mouth after drinking.

[0072] Comparative Example 8

[0073] Compared with Example 1, Comparative Example 8 only contains the mulberry leaf extract, and the single mulberry leaf extract is added to the 42-degree edible alcohol body at a dosage of 104 mg / L to conduct a comparative study on the degree of dry mouth after drinking.

[0074] A comparative study on the degree of dry mouth after drinking was conducted on the 42-degree alcohol bodies added with the traditional Chinese medicine compositions of Comparative Examples 1-4 and the single traditional Chinese medicine extracts of Comparative Examples 5-8. The 42-degree alcohol body added with the composition of Example 1 was used as the control group, and the serum osmotic pressure values 1 hour after drinking were measured for each test group. The specific analysis of the data analysis results is shown in Table 2.

[0075] Table 2: Serum osmotic pressure values of mice in each group of Comparative Examples 1-8

[0076] Group Mouse serum osmotic pressure value 42-degree liquor body added with the composition of Example 1 419.7±7.2 42-degree liquor body added with the composition of Comparative Example 1 452.8±5.4&&& 42-degree liquor body added with the composition of Comparative Example 2 447.3±12.6& 42-degree liquor body added with the composition of Comparative Example 3 441.7±8.9&& 42-degree liquor body added with the composition of Comparative Example 4 462.3±14.8&& 42-degree liquor body added with the composition of Comparative Example 5 455.0±13.9&&& 42-degree liquor body added with the composition of Comparative Example 6 446.0±11.34& 42-degree liquor body added with the composition of Comparative Example 7 445.0±11.5& 42-degree liquor body added with the composition of Comparative Example 8 452.5±4.2&&&

[0077] Note: Compared with the group of "42-degree alcohol body added with the composition of Example 1", " & " means p < 0.05; " && " means p < 0.01; " &&& " means p < 0.001.

[0078] The data in Table 2 show that when the compositions in Comparative Examples 1-4 were added to the 42-degree edible alcohol body at a dosage of 400 mg / L, the serum osmotic pressure values of the mice after drinking were significantly up-regulated compared with the previous 419.7. When the single traditional Chinese medicine extracts in Comparative Examples 5-8 were added to the 42-degree edible alcohol body at the corresponding dosages, the serum osmotic pressure values of the mice after drinking were also significantly up-regulated compared with the previous 419.7.

[0079] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for relieving dry mouth after drinking, characterized in that, It comprises the following components in parts by weight: 5-50 parts of pueraria root extract, 5-50 parts of codonopsis pilosula extract, 20-65 parts of astragalus membranaceus extract, and 10-40 parts of mulberry leaf extract.

2. The traditional Chinese medicine composition for relieving dry mouth after drinking as described in claim 1, characterized in that, It comprises the following components in parts by weight: 12 parts of pueraria root extract, 12 parts of codonopsis pilosula extract, 50 parts of astragalus membranaceus extract, and 26 parts of mulberry leaf extract.

3. The traditional Chinese medicine composition for relieving dry mouth after drinking as claimed in claim 1, wherein, It comprises the following components in parts by weight: 10 parts of pueraria root extract, 36 parts of codonopsis pilosula extract, 36 parts of astragalus membranaceus extract, and 18 parts of mulberry leaf extract.

4. The traditional Chinese medicine composition for relieving dry mouth after drinking as claimed in claim 1, wherein It comprises the following components in parts by weight: 36 parts of pueraria root extract, 10 parts of codonopsis pilosula extract, 36 parts of astragalus membranaceus extract, and 18 parts of mulberry leaf extract.

5. The traditional Chinese medicine composition for relieving dry mouth after drinking alcohol according to claim 1, wherein The preparation method of the pueraria root extract comprises: pueraria root is obtained by extraction with 90% ethanol, concentration, acid hydrolysis, resin purification, concentration, crystallization, recrystallization, drying, and pulverization, and the mass content of puerarin in the pueraria root extract is ≥80%.

6. The traditional Chinese medicine composition for relieving dry mouth after drinking as claimed in claim 1, wherein, The preparation method of the codonopsis pilosula extract comprises: codonopsis pilosula is extracted with 60% ethanol and concentrated and dried, and the mass content of codonopsis pilosula polysaccharide in the codonopsis pilosula extract is ≥20%.

7. The traditional Chinese medicine composition for relieving dry mouth after drinking alcohol according to claim 1, wherein The preparation method of the astragalus membranaceus extract comprises: astragalus membranaceus is extracted with alkaline water, separated by resin, the 70% ethanol eluate is collected, concentrated and dried, and the mass content of astragaloside IV in the astragalus membranaceus extract is ≥15%.

8. The traditional Chinese medicine composition for relieving dry mouth after drinking as claimed in claim 1, wherein The preparation method of the mulberry leaf extract comprises: mulberry leaf is extracted with water, purified by resin, concentrated and dried, and the mass content of mulberry leaf flavonoids in the mulberry leaf extract is ≥5%.

9. Use of the traditional Chinese medicine composition for relieving dry mouth after drinking alcohol according to claim 1, characterized in that It is used for adding to the wine body to relieve dry mouth after drinking.

10. Use of the traditional Chinese medicine composition for relieving dry mouth after drinking as claimed in claim 1, characterized in that, The addition amount of the traditional Chinese medicine composition in the wine body is 300-500 mg / L.