Monosubstituted ester porphyrin derivatives, their preparation methods and uses as photosensitizers

By preparing monosubstituted ester porphyrin derivatives and combining light irradiation, the effectiveness and safety of existing photosensitizers in the treatment of periodontitis and gingivitis are solved, and the effective antibacterial effect on Porphyrin gingivitis is achieved. It is suitable for photodynamic therapy for the treatment of oral diseases such as periodontitis, gingivitis and tooth caries.

CN119912464BActive Publication Date: 2025-07-29SHANGHAI GUANGSHENG BIOPHARMACEUTICAL CO LTD
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Patent Information

Application Number
CN202510397204.1
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-03-31
Publication Date
2025-07-29
Estimated Expiration
2045-03-31

AI Technical Summary

Technical Problem

The existing photosensitizers have unclear active ingredients, skin phototoxic effects and drug resistance when treating oral diseases such as periodontitis, gingivitis and tooth caries. It is necessary to develop efficient and safe photosensitizers.

Method used

Monosubstituted ester porphyrin derivatives are developed to prepare photosensitizers with high permeability and biosafety through condensation reaction with compounds with reactive hydrogen atoms in the presence of catalysts and condensation agents, and treated with light irradiation at specific wavelengths.

Benefits of technology

It has achieved efficient antibacterial effects on bacteria such as Porphyromonas gingivalis, has good biosafety and industrial production potential, and is suitable for photodynamic therapy for the treatment of periodontitis, gingivitis and dental caries.

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Abstract

The present invention relates to a compound of formula (I) or a salt thereof, wherein the group R is as defined in the specification; and also relates to a method for preparing the compound and its use as a photosensitizer in photodynamic therapy. The monosubstituted protoporphyrin derivatives involved in the present invention all have high permeability, high activity, and good biosafety. The preparation method is simple, low-cost, and can obtain the target product in good yield. It is particularly suitable for industrial production and can be used as a highly effective photosensitizer in photodynamic therapy to treat oral diseases such as periodontitis, gingivitis, dental plaque, and caries caused by Gram-negative anaerobic cocci and other bacteria such as Porphyromonas gingivalis.
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