Living animal blood vessel fixing and soaking device

Abstract

The invention relates to the field of blood vessel soaking, in particular to a living animal blood vessel fixing and soaking device which comprises a first soaking cover and a second soaking cover. A first soaking groove is formed in the first soaking cover, and a first half hole communicating with the first soaking groove is formed in the first soaking cover. The first soaking cover is provided with a first soaking groove, the second soaking cover is provided with a second soaking groove, the second soaking cover is provided with a second half hole communicating with the second soaking groove, the first soaking cover can be spliced with the second soaking cover, the first soaking groove and the second soaking groove are combined to form a soaking cavity, and the first half hole and the second half hole are spliced to form a passing hole; the soaking cavity is used for wrapping animal blood vessels penetrating through the through hole. The second soaking cover is provided with a liquid adding structure connected with the soaking groove, and the liquid adding structure is used for injecting soaking liquid into the soaking cavity. The soaking cavity wraps the blood vessel of the living animal, so that the blood vessel of the living animal is isolated from the outside. The liquid adding structure enables an operator to inject soaking liquid into the soaking cavity from the outside of the soaking device to complete soaking.

Description

Technical Field

[0001] This patent relates to the field of medical blood vessel immersion, and in particular to a living animal blood vessel fixing immersion device. Background Art

[0002] In medical research on experimental animals, in order to deeply explore the physiological and pathological changes of blood vessels and the mechanism of drug action, it is often necessary to finely fix and soak the blood vessels of living animals. This process is crucial for scientific researchers. By observing the effects of drugs on living blood vessels, we can understand the effects of drugs on physiological functions such as vascular expansion, contraction, and permeability in vivo, thereby evaluating their therapeutic effects and possible side effects. Living blood vessel immersion experiments can help researchers understand the changes in blood vessels under certain disease states, such as arteriosclerosis and inflammatory responses, thereby revealing the pathogenesis of the disease. For new biomaterials, such as artificial blood vessels and stents, living blood vessel immersion experiments can be used to evaluate their compatibility with vascular tissues, stability, and possible immune responses. However, existing technical means face many challenges and limitations when implementing these operations.

[0003] Usually, to complete the blood vessel fixation and immersion operation of experimental animals, researchers need to use surgical instruments to expose the target blood vessels. Then, they will use tools such as right-angle clamps to pull the blood vessels and place hydrophobic materials under the blood vessels to isolate the blood vessels from the surrounding surgical area and prevent the drug from penetrating into non-target tissues. Then, wet gauze is used to wrap the blood vessels, and the drug is dripped onto the gauze so that the drug can penetrate into the blood vessel wall.

[0004] However, when using this method, most of the drug will penetrate into the tissue gap and cannot produce a soaking effect. At the same time, if it involves observing the soaking effect of different doses of drugs on blood vessels, the drug dose cannot be accurately measured due to the loss of the drug, and the length of the blood vessel wrapped with gauze cannot be accurately measured. Summary of the invention

[0005] In order to solve or at least partially solve the above technical problems, the present patent provides a device for fixing and soaking blood vessels of living animals, comprising: a first soaking cover and a second soaking cover. The first soaking cover is provided with a first soaking tank, and a first half hole connected to the first soaking tank is arranged on the first soaking cover. The second soaking cover is provided with a second soaking tank, and a second half hole connected to the second soaking tank is arranged on the second soaking cover. The first soaking cover can be assembled with the second soaking cover, so that the first soaking tank and the second soaking tank are combined to form a soaking chamber, and the first half hole and the second half hole are assembled to form a through hole, and the soaking chamber is used to wrap the animal blood vessels passing through the through hole. The second soaking cover is provided with a liquid adding structure connected to the soaking tank, and the liquid adding structure is used to inject soaking liquid into the soaking chamber.

[0006] Preferably, a sealing ring is provided on the through hole, and the sealing ring can fit with the animal blood vessel to seal the immersion chamber.

[0007] Preferably, the liquid adding structure comprises: a docking component and a blocking component. The docking component is arranged on the outer surface of the second soaking cover, and is provided with a through hole penetrating the docking component body. The blocking component is connected to the inner side wall of the through hole, and has a blocking surface, which faces the orifice of the through hole and is used to abut against the injection needle of the syringe to prevent the injection needle of the syringe from further extending into the soaking chamber. The blocking component leaves a gap to allow the solution released by the syringe to pass through.

[0008] Preferably, the blocking surface of the blocking component extends obliquely from the connection with the through hole toward the bottom of the through hole, and a contact groove is provided on the blocking surface, and the contact groove is used to abut against the injection needle of the syringe.

[0009] Preferably, the liquid adding structure further comprises: a drainage part. The drainage part is arranged on the blocking surface of the blocking component, and has a water flow channel, which is connected to the contact groove, and the water flow channel drains the liquid dripping into the contact groove to the soaking groove.

[0010] Preferably, the liquid adding structure further comprises: a drainage part. The drainage part is arranged above the blocking component, and the drainage part extends obliquely from the connection with the through hole toward the bottom of the through hole, and the upper surface of the drainage part is used to receive the solution released by the injection needle of the syringe.

[0011] Preferably, the liquid adding structure further includes: an anti-backflow component. The anti-backflow component is arranged on the side of the through hole facing the soaking chamber, and the anti-backflow component has a deformable adhesive film, which is attached to and covers the opening of the through hole, and has staggered gaps on the deformable adhesive film, and the gaps can form a liquid injection hole on the deformable adhesive film under the action of external force.

[0012] Preferably, the first soaking cover further comprises: a connecting piece, and the second soaking cover further comprises: a docking piece. The docking piece matches the connecting piece to connect when the first soaking cover and the second soaking cover are closed.

[0013] Preferably, the first soaking cover and the second soaking cover are rotatably connected along the length direction so as to be used for rotating to open and close the soaking chamber.

[0014] Preferably, one side of the first soaking cover is provided with a first fitting portion arranged along the length direction of the first soaking cover. One side of the second soaking cover is provided with a second fitting portion arranged along the length direction of the second soaking cover and matching the first fitting portion. The fixed soaking device further comprises: a clamping portion. The clamping portion is used to clamp the first fitting portion and the second fitting portion after closing.

[0015] Preferably, the first bonding portion is provided with a sealing strip along its length direction;

[0016] The second bonding part is provided with a sealing groove matching the sealing strip along its length direction, and the sealing strip is embedded in the sealing groove when the first bonding part and the second bonding part are closed. Or, the second bonding part is provided with a sealing strip along its length direction. The first bonding part is provided with a sealing groove matching the sealing strip along its length direction, and the sealing strip is embedded in the sealing groove when the first bonding part and the second bonding part are closed.

[0017] Compared with the prior art, the present invention provides a first soaking cover and a second soaking cover, and combines the first soaking cover and the second soaking cover into a soaking chamber to wrap the blood vessels of the living animal to be soaked, so that the blood vessels of the living animal can be completely wrapped inside the soaking chamber. At the same time, the liquid can be injected from the outside of the soaking device into the soaking chamber through the liquid adding structure. Since the soaking chamber is in a sealed state, the blood vessels of the living animal located in the soaking chamber can be completely soaked and wrapped, and the liquid in the soaking chamber can be prevented from flowing out. In addition, the soaking device can directly limit the length of the blood vessels of the living animal, so as to achieve precise control of the soaking length of the blood vessels of the living animal. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the implementation of this patent, the following is a brief introduction to the relevant drawings. It can be understood that the drawings described below are only used to illustrate some implementations of this patent, and ordinary technicians in this field can also obtain many other technical features and connection relationships not mentioned in this article based on these drawings.

[0019] Figure 1 This is a schematic diagram of the three-dimensional structure of a living animal blood vessel fixing and immersion device according to an embodiment of the present patent;

[0020] Figure 2 This is a schematic diagram of the three-dimensional structure of a living animal blood vessel fixing and immersion device according to an embodiment of the present patent;

[0021] Figure 3 This is a schematic diagram of the three-dimensional structure of a living animal blood vessel fixing and immersion device according to an embodiment of the present patent;

[0022] Figure 4 This is a schematic diagram of the three-dimensional structure of a living animal blood vessel fixing and immersion device according to an embodiment of the present patent;

[0023] Figure 5 This is a schematic diagram of the three-dimensional structure of a living animal blood vessel fixing and immersion device according to an embodiment of the present patent;

[0024] Figure 6 The embodiment of the present patent is a three-dimensional structural schematic diagram of a docking component of a living animal blood vessel fixing and immersion device according to the embodiment of the present patent;

[0025] Figure 7 The embodiment of the present patent is a three-dimensional structural schematic diagram of a docking component of a living animal blood vessel fixing and immersion device according to the embodiment of the present patent;

[0026] Figure 8 It is a schematic diagram of the three-dimensional structure of a living animal blood vessel fixing and immersion device after being placed inside the living animal blood vessel in the embodiment of the present patent;

[0027] Fig. 9 It is a schematic diagram of the three-dimensional structure of a living animal blood vessel fixing and immersion device after being placed inside the living animal blood vessel in the embodiment of the present patent;

[0028] Fig.10 The three-dimensional structural diagram of an implementation method of this patent is when the injection needle is inserted into the docking component.

[0029] Description of reference numerals:

[0030] 1. First soaking cover; 11. First soaking tank; 12. First fitting part; 121. Sealing rubber strip; 13. First half hole; 2. Second soaking cover; 21. Second soaking tank; 22. Second fitting part; 221. Sealing tank; 23. Second half hole; 3. Sealing ring; 31. Sealing rubber ring; 4. Connecting piece; 5. Docking piece; 6. Liquid adding structure; 61. Docking part; 62. Blocking part; 63. Anti-backflow part; 64. Drainage part. DETAILED DESCRIPTION

[0031] The patent is described in detail below in conjunction with the accompanying drawings.

[0032] At present, there are significant defects in the gauze wrapping method used in experiments on living blood vessels immersion. First, due to the uncontrollability of drug penetration, most drugs will penetrate into the tissue gap rather than the target blood vessels. This causes researchers to use relatively more drug doses to ensure the infiltration effect on the blood vessels. However, doing so not only increases the cost of the experiment, but may also cause unnecessary harm to the experimental animals. Drugs present in the tissue gap may affect the surrounding tissues and blood vessels, thereby interfering with the accuracy of the experimental results. This is a serious drawback for studies that require accurate assessment of the effects of drugs on blood vessels. Existing methods cannot quantitatively control the length of blood vessels exposed to drugs. This means that researchers cannot accurately control the scope and extent of drug action, which in turn affects the experimental results and accuracy.

[0033] In view of this, the first embodiment of this patent proposes a living animal blood vessel fixing immersion device to solve the above-mentioned technical problems.

[0034] First embodiment

[0035] refer to Figure 1 , Figure 3 The patent shown provides a device for fixing and soaking blood vessels of living animals, including: a first soaking cover 1 and a second soaking cover 2. The first soaking cover 1 is provided with a first soaking tank 11, and a first half hole 13 connected to the first soaking tank 11 is arranged on the first soaking cover 1. The second soaking cover 2 is provided with a second soaking tank 21, and a second half hole 23 connected to the second soaking tank 21 is arranged on the second soaking cover 2. The first soaking cover 1 can be assembled with the second soaking cover 2, so that the first soaking tank 11 and the second soaking tank 21 are combined to form a soaking chamber, and the first half hole 13 and the second half hole 23 are assembled to form a through hole, and the soaking chamber is used to wrap the animal blood vessels passing through the through hole. The second soaking cover 2 is provided with a liquid adding structure 6 connected to the soaking tank, and the liquid adding structure 6 is used to inject soaking liquid into the soaking chamber.

[0036] When the blood vessels of living animals are fixedly immersed, it is first necessary to separate the first immersion cover 1 from the second immersion cover 2, and place the target segment of the blood vessel of the living animal into the first immersion tank 11 of the first immersion cover 1, or into the second immersion tank 21 of the second immersion cover 2. When the first immersion cover 1 and the second immersion cover 2 are assembled, the immersion chamber formed by the two covers can completely wrap the target segment of the blood vessel. Since the lengths of the first immersion cover 1 and the second immersion cover 2 are fixed, the length of the blood vessel of the living animal wrapped therein is also precisely controlled. Specifically, the length of the immersion chamber is equal to the length of the blood vessel of the living animal wrapped therein. In addition, in order to ensure that the blood vessels are not damaged, a special structure is designed - by connecting the first half hole 13 with the second half hole 23 to form a complete through hole, the two ends of the blood vessel of the living animal can extend from this through hole to the outside of the immersion chamber, thereby avoiding any potential damage caused by the device itself.

[0037] Next, align the prepared syringe with the preset liquid adding interface on the second soaking cover 2. Figure 2 As shown. By pushing the syringe piston, the pre-prepared immersion solution can be injected into the entire immersion chamber. Once all the space is filled, the blood vessel part located therein will be thoroughly infiltrated, achieving ideal experimental conditions. It is worth noting that the "first half hole 13" and the "second half hole 23" here refer to a special design idea: that is, each cover has a small hole that is not completely through, and only when the two covers are tightly fitted together, these small holes will be connected in a line to form a channel that allows blood vessels to pass through without being compressed.

[0038] Further, refer to Figure 1 , Figure 2 , Figure 3 A sealing ring 3 is provided on the through hole, and the sealing ring 3 can fit with the animal blood vessel to seal the immersion chamber.

[0039] When the live animal blood vessel immersion device is fixing and immersing the target blood vessel segment, the immersion chamber will be filled with immersion liquid. Figure 8 and Fig. 9 In the design shown, the blood vessels other than the target segment need to be exposed outside the immersion chamber, so these blood vessels will fit closely to the through hole. In order to prevent the immersion liquid from leaking out of the gap between the blood vessel and the through hole, a sealing ring 3 made of a soft and elastic material is specially provided to close the gap, ensuring that only the target segment of the blood vessel can be fully and evenly infiltrated. In addition, considering that the outer surface of the blood vessel of a living animal is oily, the sealing ring 3 that fits the outer surface of the blood vessel can be made of polytetrafluoroethylene, which has excellent high temperature resistance and corrosion resistance, low friction coefficient and good self-lubricating properties, so as to avoid being corroded by the grease on the outer surface of the blood vessel while protecting the blood vessel of the living animal.

[0040] Second embodiment

[0041] In the first embodiment, a device for soaking blood vessels of living animals is disclosed, wherein the length of the soaked blood vessels of living animals is confirmed by a first soaking cover 1 and a second soaking cover 2 of fixed length and capable of opening and closing. At the same time, the soaking chamber composed of the first soaking tank 11 and the second soaking tank 21 is filled with liquid by a liquid adding structure 6. However, since the internal conditions of the soaking chamber cannot be directly observed by naked eyes during the liquid injection process, it is difficult to control the insertion depth of the syringe. When the syringe is inserted in transition, the needle of the syringe may come into contact with the blood vessels of living animals in the soaking chamber.

[0042] In view of this, the second embodiment of the present application is improved compared with the first embodiment in that, referring to Figure 4 , Figure 6 The liquid adding structure 6 shown includes: a docking component 61 and a blocking component 62. The docking component 61 is arranged on the outer surface of the second soaking cover 2, and the docking component 61 is provided with a through hole penetrating the docking component 61 body. The blocking component 62 is connected to the inner side wall of the through hole, and the blocking component 62 has a blocking surface, which faces the orifice of the through hole and is used to abut against the injection needle of the syringe to prevent the injection needle of the syringe from further extending into the soaking chamber. The blocking component 62 leaves a gap to allow the solution released by the syringe to pass through.

[0043] When it is necessary to inject the soaking liquid into the soaking chamber, the syringe is first connected to the docking piece 5. The needle tip of the syringe can pass through the through hole and finally contact the surface of the blocking piece. At this time, due to the existence of the blocking piece, it can prevent the needle tip of the syringe from continuing to penetrate into the soaking chamber. Subsequently, the syringe piston is pushed manually or mechanically, and the liquid stored therein flows out through the needle tip and then slowly enters the soaking chamber through the gap between the blocking pieces. This design uses physical barriers to limit excessive insertion of the needle tip, thereby effectively protecting the blood vessels of the experimental animals placed in the soaking chamber from damage.

[0044] Of course, in order to improve the blocking success rate of the blocking component 62, the edge of the blocking component 62 can be fully connected with the inner wall of the through hole. A small water flow hole can be opened on the body of the blocking component 62, and the soaking liquid dripping on the blocking component 62 can flow down through the water flow hole and flow into the soaking chamber. By setting a larger blocking component 62, the blocking success rate of the blocking component 62 for the injection needle is improved. Of course, the falling speed of the soaking liquid will also be relatively affected, and the size of the blocking component 62 can be adjusted according to actual needs.

[0045] Further, refer to Figure 6 The blocking surface of the blocking component 62 shown in the figure extends obliquely from the connection with the through hole toward the bottom of the through hole, and a contact groove is provided on the blocking surface, and the contact groove is used to abut against the injection needle of the syringe. The liquid adding structure 6 also includes: a drainage part 64. The drainage part 64 is provided on the blocking surface of the blocking component 62, and the drainage part 64 has a water flow channel, which is connected to the contact groove, and the water flow channel drains the liquid dripping in the contact groove to the immersion tank.

[0046] In order to effectively prevent the syringe needle from going too deep and allow the soaking liquid to enter the soaking chamber smoothly, we use a specially structured blocking member in the design. The blocking member not only has an inclined blocking surface, but also has a contact groove specially used to guide the flow of liquid and its matching drainage portion 64. When the syringe is pushed in, its needle tip first contacts the contact groove on the blocking member, which not only limits the position of the needle to prevent it from swinging left and right, but also provides a stable platform for the subsequent transfer of liquid.

[0047] Subsequently, as more liquid is squeezed out, it will first fill the small groove, then slowly flow out through the drainage portion 64, and finally all gather in the soaking chamber. In the whole process, thanks to this ingenious design arrangement, waste can be minimized and the expected effect can be achieved every time the operation is performed.

[0048] Third embodiment

[0049] In the second embodiment of the present application, a blocking component 62 is provided in the liquid adding structure 6, and the blocking component 62 prevents the injection needle of the syringe from further extending into the immersion chamber, so as to protect the blood vessels of the living animal in the immersion chamber. However, during operation, the injection needle of the syringe needs to be aligned with the contact groove, so the difficulty of precision control is relatively high.

[0050] In view of this, refer to Figure 7 The improvement of the third embodiment of the present application compared with the second embodiment is that the liquid adding structure 6 further includes: a drainage portion 64. The drainage portion 64 is arranged above the blocking component 62, and the drainage portion 64 extends obliquely from the connection with the through hole toward the bottom of the through hole, and the upper surface of the drainage portion 64 is used to receive the solution released by the injection needle of the syringe.

[0051] Since the drainage portion 64 is disposed above the blocking member 62, the drainage portion 64 and the blocking member 62 form a staggered configuration. When the soaking liquid is added, the soaking liquid in the syringe will drip onto the drainage portion 64 through the injection needle, and then be guided into the soaking chamber by the drainage portion 64. Fig.10 As shown, the blocking component 62 is located below the drainage portion 64. When the injection needle of the syringe penetrates into the through hole of the docking portion, even if the syringe is inserted to a deep depth, it can be blocked by the drainage portion 64 first. If the injection needle of the syringe is offset when inserted, resulting in the injection needle not contacting the drainage portion 64, but directly extending to the bottom of the drainage portion 64, the injection needle will abut against the blocking component 62 located below the drainage portion 64 to avoid further insertion. At the same time, the upper surface of the blocking component 62 is also inclined, which can guide part of the dripping soaking liquid and allow the soaking liquid to flow into the soaking chamber.

[0052] In order to ensure the safety and accuracy of the injection process, the design of the drainage part 64 and the blocking part 62 adopts a high-precision manufacturing process. The drainage part 64 is usually made of medical-grade silicone or plastic material, has good biocompatibility and chemical resistance, and can withstand multiple uses without deformation or damage. The blocking part 62 may be made of metal or hard plastic material to ensure its structural strength and durability. In practical applications, the injection needle of the syringe may deviate from the predetermined trajectory due to hand shaking or other reasons. In order to prevent this from happening, the design of the drainage part 64 and the blocking part 62 takes into account a variety of factors, including the diameter and length of the needle and the user's operating habits. It can be intuitively seen that the drainage part 64 and the blocking part 62 can both block the injection needle of the syringe during its insertion. Therefore, even if the syringe needle is not aligned with the drainage part 64 when it is inserted, the injection needle of the syringe can be blocked by the blocking part 62 to prevent the injection needle from further extending into the immersion chamber. This design improves the error tolerance when the syringe is docked with the blood vessel immersion device, and avoids the risk of the injection needle of the syringe extending into the blood vessel immersion device.

[0053] At the same time, reference Figure 7 As shown, the cross-section of the drainage portion 64 and the blocking component 62 can be designed to be a triangle. The right triangle has an inclined surface, which can be used to carry the soaking liquid dripping from the injection needle of the syringe and guide the dripping soaking liquid into the soaking chamber. In addition, when the syringe is used to dock with the liquid adding structure 6, the drainage portion 64 and the blocking component 62 will directly dock with the injection needle, so the drainage portion 64 and the blocking component 62 need to withstand the external force from the injection needle. The drainage portion 64 and the blocking component 62 with a triangular cross-section are more stable in structure, so the drainage portion 64 and the blocking component 62 can be repeatedly used many times, increasing the service life of the liquid adding structure 6.

[0054] In order to improve the stability and service life of the liquid adding structure 6, the drainage portion 64 and the blocking component 62 are designed with a triangular cross section. This design not only helps to disperse the pressure applied by the injection needle, but also effectively guides the dripping soaking liquid into the soaking chamber. The inclined surface of the right triangle is particularly suitable for the flow of liquid because it provides a smooth surface and reduces the resistance when the liquid flows. In addition, the triangular structure has a high mechanical stability, which allows the drainage portion 64 and the blocking component 62 to maintain their shape and function even after long-term use.

[0055] In actual medical operations, syringes are used frequently, so the durability of the liquid adding structure 6 is particularly important. The triangular cross-section design can significantly improve the durability of the liquid adding structure 6 and reduce the replacement frequency due to wear or deformation. This not only reduces medical costs, but also improves work efficiency.

[0056] Fourth embodiment

[0057] In the previous embodiments of the present application, the blood vessel disposed inside is infiltrated by the blood vessel immersion device, and the immersion liquid is injected into the immersion chamber through the liquid adding structure 6. In the subsequent experimental process, the blood vessel of the animal may shake due to breathing or other external collisions, causing the blood vessel immersion device to fall or shake, causing the immersion liquid to flow out of the liquid adding structure 6.

[0058] In view of this, refer to Figure 2 The fourth embodiment of the present application is improved compared with the previous embodiment in that the liquid adding structure 6 further includes: an anti-backflow component 63. The anti-backflow component 63 is arranged on the side of the through hole facing the soaking chamber, and the anti-backflow component 63 has a deformable adhesive film, which is attached to and covers the orifice of the through hole, and has staggered slits on the deformable adhesive film, and the slits can form a liquid injection hole on the deformable adhesive film under the action of external force.

[0059] After the injection needle of the syringe is inserted into the liquid adding structure 6, as the injection needle gradually extends, the injection needle will contact the deformable rubber film of the anti-backflow component 63. Under the action of the injection needle, the deformable rubber film will deform in the direction of the immersion chamber and form a liquid injection hole, so that the immersion liquid in the syringe flows into the immersion chamber. The deformable rubber film is usually made of highly elastic material to ensure that it can be deformed when subjected to external force and quickly return to its original state after the external force disappears. This design can not only effectively prevent liquid reflux, but also ensure that good sealing performance is maintained after multiple uses.

[0060] Furthermore, when the syringe is finished filling and the syringe and the liquid adding structure 6 are separated from each other, the deformable adhesive film will recover due to the loss of external force, so that the originally formed liquid injection hole is closed. The closed liquid injection hole cannot allow the soaking liquid to pass through, so even if the soaking device is shaken or tilted, the soaking liquid in the soaking chamber will not flow out through the liquid adding structure 6, thereby ensuring the capacity of the soaking liquid in the soaking chamber.

[0061] In addition, reference Figure 1 , Figure 2 and Figure 3 The first soaking cover 1 further comprises a connecting member 4, and the second soaking cover 2 further comprises a docking member 5. The docking member 5 matches the connecting member 4 to connect the first soaking cover 1 and the second soaking cover 2 when they are closed.

[0062] Since the soaking chamber requires the first soaking cover 1 and the second soaking cover 2 to be combined and form the soaking chamber, the first soaking cover 1 and the second soaking cover 2 must fit tightly to ensure that the soaking chamber always remains formed and sealed. Through the use of high-precision processing technology and special materials, the sealing effect can be significantly improved and the possibility of leakage can be reduced. The design of the connector 4 and the docking piece 5 is also one of the key factors to ensure sealing. Common connection methods include threaded connection, snap connection and magnetic connection, etc., which can be selected according to actual needs. In this embodiment, a snap connection is used as the connection method between the connector 4 and the docking piece 5.

[0063] At the same time, reference Figure 1 , Figure 2 and Figure 3 The first soaking cover 1 and the second soaking cover 2 are rotatably connected along the length direction so as to be used for rotating to open and close the soaking chamber.

[0064] During the experiment of immersing the blood vessels of living animals, fine tools such as tweezers are usually used to operate the immersion fixture because the blood vessels of living animals are small and thin. When the first immersion cover 1 is connected to one side of the second immersion cover 2 by rotation, they will not separate even if they are in an open state, thereby avoiding the loss of the first immersion cover 1 or the second immersion cover 2. In addition, since the first immersion cover 1 and the second immersion cover 2 are already connected on one side, there is no need to align them when merging them. They only need to be folded relative to each other to merge them, which simplifies the operation process of the immersion fixture for fixing blood vessels of living animals. This design not only improves the convenience of operation, but also enhances the structural stability of the entire device. Some advanced immersion fixtures are also equipped with microscopes or other magnifying devices so that researchers can observe and operate the target area more clearly, further improving the accuracy and repeatability of the experiment.

[0065] Fifth embodiment

[0066] During the soaking of the blood vessels of living animals, the sealing of the soaking chamber will directly affect the soaking effect of the blood vessels of living animals. Therefore, the sealing needs to be ensured especially at the joint of the first soaking cover 1 and the second soaking cover 2 to prevent the soaking liquid in the soaking chamber from leaking out.

[0067] In view of this, refer to Figure 3 and Figure 5 The improvement of the fifth embodiment of the present application compared with other embodiments is that the first soaking cover 1 has a first fitting portion 12 arranged along the length direction of the first soaking cover 1 on one side of the opening and closing. The second soaking cover 2 has a second fitting portion 22 along the length direction of the second soaking cover 2 and matching the first fitting portion 12 on one side of the opening and closing. The fixed soaking device also includes: a clamping portion. The clamping portion is used to clamp the first fitting portion 12 and the second fitting portion 22 after closing.

[0068] When the first soaking cover 1 and the second soaking cover 2 are combined, the first fitting portion 12 on the first soaking cover 1 will fit with the second fitting portion 22 on the second soaking cover 2. Originally, the edges of the first soaking cover 1 and the second soaking cover 2 were thinner, and the design of the first fitting portion 12 and the second fitting portion 22 increased the contact area between them. This design of increasing the contact area not only enhances the stability of the living animal blood vessel soaking device after fitting, but also generates interactive pressure when the first fitting portion 12 and the second fitting portion 22 are combined, thereby forming a sealed isolation layer, effectively preventing the soaking liquid in the soaking chamber from flowing out, and improving the sealing of the soaking chamber. In addition, the clamping portion can clamp the first fitting portion 12 and the second fitting portion 22 after they are fitted to prevent the two from separating, ensuring that the first soaking cover 1 and the second soaking cover 2 remain in a combined state, thereby ensuring the integrity of the soaking chamber.

[0069] In order to further improve the sealing performance, the first fitting part 12 and the second fitting part 22 are usually made of soft but elastic materials, such as silicone or rubber. These materials can provide good sealing effects and adapt to blood vessels of different shapes and sizes. In addition, some designs will add special coatings or use deformable structures on these fitting parts to better adapt to the contours of the blood vessels and reduce the risk of leakage.

[0070] Further, refer to Figure 3 and Figure 5 The first bonding part 12 is provided with a sealing strip 121 along its length direction, and the second bonding part 22 is provided with a sealing groove 221 matching the sealing strip 121 along its length direction, so that when the first bonding part 12 and the second bonding part 22 are closed, the sealing strip 121 is embedded in the sealing groove 221. Alternatively, the second bonding part 22 is provided with a sealing strip 121 along its length direction. The first bonding part 12 is provided with a sealing groove 221 matching the sealing strip 121 along its length direction, so that when the first bonding part 12 and the second bonding part 22 are closed, the sealing strip 121 is embedded in the sealing groove 221.

[0071] When the first soaking cover 1 and the second soaking cover 2 are attached, the sealing strip 121 will be embedded in the corresponding sealing groove 221. The sealing strip 121 can fill the gap between the first attaching part 12 and the second attaching part 22 after they are combined, so as to prevent the soaking liquid in the soaking groove from flowing out from the gap between the two. In addition, the sealing strip 121 needs to be squeezed and deformed during the insertion into the sealing groove 221, so that an interference fit is formed between the sealing groove 221, thereby generating additional connection force between the first attaching part 12 and the second attaching part 22.

[0072] Furthermore, when the first soaking cover 1 and the second soaking cover 2 are two completely separate entities, they need to be aligned and docked each time they are assembled. By providing the sealing strip 121 and the sealing groove 221 on the first fitting portion 12 and the second fitting portion 22, the sealing strip 121 and the sealing groove 221 can play a positioning role. Once the sealing strip 121 is successfully embedded in the sealing groove 221, it indicates that the first soaking cover 1 and the second soaking cover 2 have been fitted together.

[0073] In order to make the embedding process of the sealing strip 121 smoother, the sealing strip 121 can be designed with a circular cross section. When the sealing strip 121 with a circular cross section is embedded in the sealing groove 221, its arc surface reduces the interference of the sealing groove 221 on the sealing strip 121, so that the sealing strip 121 can be smoothly embedded in the sealing groove 221. This design not only improves the sealing effect, but also enhances the stability and reliability of the entire device.

[0074] Finally, it should be noted that ordinary technicians in this field can understand that in order to make readers better understand this patent, the implementation methods of this patent propose many technical details. However, even without these technical details and various changes and modifications based on the above-mentioned implementation methods, the technical solutions claimed for protection by the claims of this patent can be basically realized. Therefore, in practical applications, various changes can be made to the above-mentioned implementation methods in form and details without departing from the spirit and scope of this patent.

Claims

1. A device for fixing and immersing blood vessels of living animals, characterized in that: include: A first soaking cover (1) is provided with a first soaking tank (11); the first soaking cover (1) is provided with a first half hole (13) communicating with the first soaking tank (11); The second soaking cover (2) is provided with a second soaking tank (21), the second soaking cover (2) is provided with a second half hole (23) connected with the second soaking tank (21), the first soaking cover (1) can be assembled with the second soaking cover (2), so that the first soaking tank (11) and the second soaking tank (21) are combined to form a soaking chamber, and the first half hole (13) and the second half hole (23) are assembled to form a through hole, and the soaking chamber is used to wrap the animal blood vessel passing through the through hole; The second soaking cover (2) is provided with a liquid adding structure (6) connected to the soaking tank, and the liquid adding structure (6) is used to inject soaking liquid into the soaking chamber.

2. The fixed soaking device according to claim 1, characterized in that: A sealing ring (3) is provided on the through hole; The sealing ring (3) can fit the animal blood vessel to seal the soaking chamber.

3. The fixed soaking device according to claim 1, characterized in that: The liquid adding structure (6) comprises: A docking component (61) is arranged on the outer surface of the second soaking cover (2), and the docking component (61) is provided with a through hole penetrating the body of the docking component (61); a blocking component (62) connected to the inner side wall of the through hole, the blocking component (62) having a blocking surface, the blocking surface facing the orifice of the through hole, and used to abut against the injection needle of the syringe to prevent the injection needle of the syringe from further extending into the soaking chamber; The blocking member (62) leaves a gap to allow the solution released from the syringe to pass through.

4. The fixed soaking device according to claim 3, characterized in that: The blocking surface of the blocking component (62) extends obliquely from the connection with the through hole toward the bottom of the through hole, and a contact groove is provided on the blocking surface, and the contact groove is used to abut against the injection needle of the syringe.

5. The fixed soaking device according to claim 4, characterized in that: The liquid adding structure (6) further comprises: The drainage portion (64) is arranged on the blocking surface of the blocking component (62), and the drainage portion (64) has a water flow channel, which is connected to the contact groove, and the water flow channel drains the liquid dripping into the contact groove to the immersion groove.

6. The fixed soaking device according to claim 3, characterized in that: The liquid adding structure (6) further comprises: A drainage portion (64) is arranged above the blocking component (62), and the drainage portion (64) extends obliquely from a connection with the through hole toward the bottom of the through hole; The upper surface of the drainage portion (64) is used to receive the solution released by the injection needle of the syringe.

7. The fixed soaking device according to claim 1, characterized in that: The liquid adding structure (6) further comprises: A backflow prevention component (63) is arranged on a side of the through hole facing the soaking chamber; The backflow prevention component (63) has a deformable rubber film, the deformable rubber film is attached to and covers the opening of the through hole, and the deformable rubber film has staggered slits, which can form injection holes on the deformable rubber film under the action of external force.

8. The fixed soaking device according to claim 1, characterized in that: The first soaking cover (1) also includes: Connector (4); The second soaking cover (2) also includes: A docking piece (5) matches the connecting piece (4) so ​​as to connect the first soaking cover (1) and the second soaking cover (2) when they are closed.

9. The fixed soaking device according to claim 1, characterized in that: The first soaking cover (1) and the second soaking cover (2) are rotatably connected along the length direction so as to be used for rotatably opening and closing the soaking chamber.

10. The fixed soaking device according to claim 1, characterized in that: One side of the first soaking cover (1) that is opened and closed has a first fitting portion (12) arranged along the length direction of the first soaking cover (1); One side of the second soaking cover (2) that is opened and closed has a second fitting portion (22) along the length direction of the second soaking cover (2) and matching the first fitting portion (12); The fixed soaking device also includes: The clamping portion is used to clamp the first laminating portion (12) and the second laminating portion (22) after they are closed.

11. The fixed soaking device according to claim 10, characterized in that: The first fitting portion (12) is provided with a sealing strip (121) along its length direction; The second bonding portion (22) is provided with a sealing groove (221) matching the sealing strip (121) along its length direction, so that when the first bonding portion (12) and the second bonding portion (22) are closed, the sealing strip (121) is embedded in the sealing groove (221); Or, the second fitting portion (22) is provided with a sealing strip (121) along its length direction; The first bonding portion (12) is provided with a sealing groove (221) matching the sealing strip (121) along its length direction, so that the sealing strip (121) is embedded in the sealing groove (221) when the first bonding portion (12) and the second bonding portion (22) are closed.

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