Film-forming type mouth wash solution based on natural polysaccharide

Abstract

The invention discloses a film-forming type mouth wash based on natural polysaccharide, and belongs to the technical field of oral care. Comprising water, auxiliary materials and functional components, and the functional components comprise, by mass, 5%-10% of natural polysaccharide, 0.05%-0.1% of sodium fluoride, 0.05%-0.2% of menthol, 5%-10% of glycerinum, 2%-5% of ethyl alcohol and 0.5%-1% of vitamin C. The problems that existing mouthwash is poor in film-forming property, short in continuous protection time, poor in inhibition effect on oral germs and limited in protection effect on oral mucosa are solved.

Description

Technical Field

[0001] The invention belongs to the technical field of oral care, and in particular relates to a film-forming mouthwash solution based on natural polysaccharides. Background Art

[0002] With the continuous advancement of oral health product technology, mouthwash, as an important part of daily oral care, has gradually received more and more attention. Although current mouthwash products have achieved certain results in antibacterial and anti-inflammatory aspects, they still have some shortcomings in film-forming performance, continuous protection time, inhibition of oral pathogens and protection of oral mucosa, which need further improvement.

[0003] A Chinese patent with publication number CN107998029B discloses a method for preparing a mouthwash containing carob leaf extract. The patent adopts an ethanol extraction process to replace the methanol extraction process, and applies the extracted carob leaf ethanol extract to the preparation of mouthwash, thereby developing a new type of mouthwash with a stronger Listeria monocytogenes inhibitory effect. However, the technical solution mainly focuses on improving the inhibitory effect on Listeria monocytogenes, while paying less attention to the film-forming performance and sustained protection time of the mouthwash.

[0004] A Chinese patent with publication number CN105497166B provides a new use of nasturtium for increasing the secretion of immunoglobulins through mucosal administration, so as to increase the secretion of immunoglobulins, and the nasturtium can be mixed into mouthwash, toothpaste, and chewing gum for use. However, the technical solution mainly focuses on increasing the secretion of immunoglobulins through mucosal administration, and pays less attention to the film-forming properties of mouthwash, the duration of protection, and the inhibitory effect on oral bacteria.

[0005] The above problems indicate that existing mouthwashes still have certain deficiencies in terms of film-forming performance, sustained protection time, inhibitory effect on oral pathogens, and protective effect on oral mucosa. Summary of the invention

[0006] The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a film-forming mouthwash solution based on natural polysaccharides with good film-forming property and long continuous protection time.

[0007] The technical solution adopted by the present invention to solve the technical problem is: a film-forming mouthwash solution based on natural polysaccharides, comprising water, auxiliary materials and functional components, characterized in that the functional components and their mass percentages in the mouthwash solution are: natural polysaccharides 5%-10%, sodium fluoride 0.05%-0.1%, menthol 0.05%-0.2%, glycerol 5%-10%, ethanol 2%-5%, and vitamin C 0.5%-1%.

[0008] The present invention provides a film-forming mouthwash solution based on natural polysaccharides, aiming to solve the problems of poor film-forming performance, short continuous protection time, poor inhibitory effect on oral pathogens, and limited protective effect on oral mucosa of existing mouthwashes. Natural polysaccharides are a natural polymer material with high viscosity and film-forming properties, which are widely found in plants and microorganisms, such as seaweed polysaccharides and chitosan. By utilizing the film-forming properties of natural polysaccharides, the film-forming performance and continuous protection time of mouthwashes can be significantly improved, while at the same time providing better protection for the oral mucosa.

[0009] Specifically, the excipients and their mass percentages in the mouthwash solution are: xanthan gum 1%~5%, citric acid 0.1%~0.5%, sodium benzoate 0.01%~0.05% and sodium saccharin 0.01%~0.02%. An appropriate amount of xanthan gum can form a composite gel network with natural polysaccharides, significantly increase the viscosity of the solution (500 mPa·s~2000 mPa·s), extend the film-forming time to 4~6 hours, increase the storage modulus by 3~5 times, and enhance the mechanical strength of the film layer. Citric acid adjusts the pH to 5.5~6.0, inhibits bacterial proliferation, and synergizes with sodium benzoate to improve antibacterial efficiency. An appropriate amount of sodium saccharin can reduce the bitterness perception threshold by about 60% at a low addition amount. At the same time, the shear-thinning properties of xanthan gum ensure low viscosity during gargling and high viscosity after standing. The addition amounts of all excipients are lower than the FDA / CFDA limits and pass the cytotoxicity test. In vitro simulation tests show that the formula has a clearance rate of more than 92% for mutans streptococcus biofilm, and the film layer remains intact after being immersed in artificial saliva for 6 hours. The excipient system achieves breakthrough improvements in film-forming performance, long-term antibacterial properties, and user experience while ensuring safety through the triple mechanisms of rheological regulation, pH synergy, and sensory optimization.

[0010] Specifically, the preparation steps of the natural polysaccharide are: 1) Soak seaweed polysaccharide and chitosan in a mass ratio of 10:1-6 at a temperature of 60°C-80°C for 30 min-60 min, and then use ultrasonic treatment for 20 min-30 min while mechanically stirring to obtain a natural polysaccharide suspension; a combination of warm water soaking, mechanical stirring and ultrasonic treatment is used to remove impurities in the natural polysaccharide and improve the solubility of the polysaccharide.

[0011] 2) The natural polysaccharide suspension is initially filtered through a microporous filter membrane, and then the polysaccharide is further extracted by supercritical carbon dioxide extraction; the extracted polysaccharide is further concentrated through a nanofiltration membrane; the concentrate is freeze-dried to obtain the natural polysaccharide.

[0012] This preparation method expands the molecular chains of seaweed polysaccharides and chitosan in warm water, and combines the synergistic effect of mechanical stirring and ultrasonic treatment to increase the dissolution rate of polysaccharides to 98%, while activating active sites; high-purity extraction (>95%) is achieved by using microporous membrane primary filtration and supercritical CO2 extraction, and nanofiltration membrane intelligent concentration is combined to remove residual water and freeze-drying to form a porous network structure, which increases water retention by 40%, shortens the re-dissolution time to within 30 seconds, and retains >99% of heat-sensitive components. The contact angle of the film-forming liquid is reduced to 15°, the oral mucosal adhesion is 0.8 N / cm², the 12-hour sustained release rate remains above 90%, and the protection time is extended by more than 3 times.

[0013] Preferably, in step 1) of preparing natural polysaccharides, the mechanical stirring speed is 1000 r / min to 1500 r / min, and the ultrasonic power of ultrasonic treatment is 200 W to 300 W. The preferred combination of mechanical stirring speed and ultrasonic power can significantly improve the extraction efficiency and product performance.

[0014] Preferably, the conditions for supercritical carbon dioxide extraction in step 2) of preparing natural polysaccharides are: temperature 35°C~45°C, pressure 25 MPa~35MPa, and extraction time 4h~6h. The conditions for primary filtration of the microporous filter membrane and supercritical carbon dioxide extraction are optimized, which significantly improves the extraction rate and purity of polysaccharides, while reducing the use of organic solvents and reducing environmental pollution. At a mild temperature of 35°C~45°C, the thermal stability of polysaccharides is maintained (degradation rate <5%), and the high pressure of 25MPa~35 MPa makes the density of CO2 close to that of liquid (0.7g / cm³~0.9 g / cm³), and the solubility is significantly enhanced, and the target polysaccharide extraction rate can reach more than 96%. The extraction time can ensure sufficient contact and mass transfer.

[0015] Preferably, the pore size of the nanofiltration membrane in step 2) of preparing the natural polysaccharide is 1 nm to 2 nm. The concentration treatment of the nanofiltration membrane further reduces the water content in the polysaccharide, and the freeze-dried polysaccharide has high purity and good dispersibility.

[0016] Further preferably, the obtained natural polysaccharide is added to an ethanol aqueous solution with a mass concentration of 60% to 70%, and modified by microwave-assisted reaction, the microwave power is 600W to 800W, the reaction time is 30min to 60min, and the polysaccharide solution after modification is subjected to rotary evaporation to remove ethanol to obtain a modified polysaccharide solution; and then the modified polysaccharide solution is used as the natural polysaccharide component of the film-forming mouthwash solution. The natural polysaccharide is modified by ethanol aqueous solution and microwave-assisted reaction, which improves the film-forming property and stability of the polysaccharide. The optimization of microwave power and reaction time effectively modifies the active groups in the polysaccharide molecular structure, thereby enhancing the film-forming ability of the polysaccharide in the mouthwash solution.

[0017] When the modified polysaccharide solution is mixed with other functional ingredients, stratification and uneven distribution between the ingredients can be better avoided.

[0018] Specifically, the preparation steps of the above-mentioned film-forming mouthwash solution based on natural polysaccharides include: first stirring and mixing the functional ingredients evenly; then adding auxiliary materials, and making up the volume with water, continuing to stir and mix evenly, and sterilizing the evenly mixed mouthwash solution by high temperature to obtain a film-forming mouthwash solution based on natural polysaccharides.

[0019] Preferably, during the stirring and mixing process, a high-speed shear mixer is used for uniform stirring, the stirring speed is 3000r / min~5000r / min, and the stirring time is 10min~20min to ensure that the ingredients are fully mixed.

[0020] Preferably, the high temperature sterilization temperature is 121° C. to 125° C., and the time is 15s to 20s. High temperature instantaneous sterilization ensures the sterility and safety of the mouthwash solution, and avoids product deterioration and use risks caused by microbial contamination.

[0021] Compared with the prior art, the present invention has the following beneficial effects: by adding natural polysaccharides and specific excipients, the present invention significantly improves the film-forming performance and sustained protection time of the mouthwash, the film-forming time is extended to 4-6 hours, the storage modulus is increased by 3-5 times, and the mechanical strength of the film layer is enhanced. Citric acid adjusts the pH to 5.5-6.0, inhibits bacterial proliferation, and cooperates with sodium benzoate for preservation to improve the antibacterial efficiency. Sodium saccharin reduces the bitterness perception threshold by 60%, and the shear thinning property of xanthan gum ensures low viscosity during gargling and high viscosity after standing, which improves the user experience. The amount of all excipients added is lower than the FDA / CFDA limit, and the safety is ensured by passing the cytotoxicity test. In vitro tests show that the formula has a clearance rate of more than 92% for mutans streptococcus biofilm, and the film layer remains intact after being immersed in artificial saliva for 6 hours. The production process adopts high-speed shear mixing and high-temperature instantaneous sterilization to ensure uniform mixing of ingredients and sterility of the product. The present invention has achieved a breakthrough improvement in film-forming performance, long-term antibacterial, sensory experience and safety. DETAILED DESCRIPTION

[0022] The present invention is described in detail below by way of examples. Unless otherwise specified, all raw materials used are commercially available. Example 1

[0023] Preparation of natural polysaccharides: The brown algae polysaccharide (seaweed polysaccharide) extracted from kelp and chitosan were soaked at a mass ratio of 10:4 at 70°C for 45 minutes, and then treated with 250W ultrasound at a mechanical stirring speed of 12r / min for 25 minutes to obtain a natural polysaccharide suspension.

[0024] The natural polysaccharide suspension was preliminarily filtered through a microporous filter membrane with a pore size of 1.5 nm, and then the polysaccharides were further extracted using supercritical carbon dioxide extraction (temperature 40°C, pressure 30 MPa, extraction time 5 h).

[0025] The extracted polysaccharide is concentrated by a nanofiltration membrane to remove residual water; the concentrate is freeze-dried to obtain natural polysaccharide.

[0026] Modification treatment: The obtained natural polysaccharide was added into an ethanol aqueous solution with a mass concentration of 65%, and was modified by microwave-assisted reaction at 700 W for 45 min.

[0027] The modified polysaccharide solution is subjected to rotary evaporation to remove ethanol, thereby obtaining a modified polysaccharide solution.

[0028] Preparation of mouthwash solution: 7.5% of modified polysaccharide solution (calculated as natural polysaccharide), 0.07% of sodium fluoride, 0.1% of menthol, 7.5% of glycerol, 3.5% of ethanol and 0.7% of vitamin C were stirred and mixed uniformly according to the mass ratio.

[0029] 3% xanthan gum, 0.3% citric acid, 0.03% sodium benzoate and 0.015% sodium saccharin were added in proportion by mass, the mixture was made up to volume with water, and stirring was continued at a stirring speed of 4000 r / min for 15 min.

[0030] The uniformly mixed mouthwash solution is sterilized at high temperature (122°C for 17 seconds) to obtain a film-forming mouthwash solution based on natural polysaccharides. Example 2

[0031] Preparation of natural polysaccharides: The brown algae polysaccharide (seaweed polysaccharide) extracted from kelp and chitosan were soaked at a mass ratio of 10:4 at 70°C for 45 minutes, and then treated with 250W ultrasound at a mechanical stirring speed of 12r / min for 25 minutes to obtain a natural polysaccharide suspension.

[0032] The natural polysaccharide suspension was preliminarily filtered through a microporous filter membrane with a pore size of 1.5 nm, and then the polysaccharides were further extracted using supercritical carbon dioxide extraction (temperature 40°C, pressure 30 MPa, extraction time 5 h).

[0033] The extracted polysaccharide solution is concentrated through a nanofiltration membrane to remove moisture; the concentrated solution is freeze-dried to obtain natural polysaccharides.

[0034] Preparation of mouthwash solution: The obtained natural polysaccharide 7.5%, sodium fluoride 0.07%, menthol 0.1%, glycerol 7.5%, ethanol 3.5% and vitamin C 0.7% were stirred and mixed uniformly according to the mass ratio.

[0035] 3% xanthan gum, 0.3% citric acid, 0.03% sodium benzoate and 0.015% sodium saccharin were added in proportion by mass, the mixture was made up to volume with water, and stirring was continued at a stirring speed of 4000 r / min for 15 min.

[0036] The uniformly mixed mouthwash solution is sterilized at high temperature (122°C for 17 seconds) to obtain a film-forming mouthwash solution based on natural polysaccharides. Example 3

[0037] Preparation of natural polysaccharides: The brown algae polysaccharide (seaweed polysaccharide) extracted from kelp was soaked at 70°C for 45 minutes, and then treated with 250W ultrasonic wave at a mechanical stirring speed of 12r / min for 25 minutes to obtain a seaweed polysaccharide suspension.

[0038] The seaweed polysaccharide suspension was preliminarily filtered through a microporous filter membrane with a pore size of 1.5 nm, and then the seaweed polysaccharide was further extracted using supercritical carbon dioxide extraction (temperature 40°C, pressure 30 MPa, extraction time 5 h).

[0039] The extracted seaweed polysaccharide is concentrated by a nanofiltration membrane to remove water; the concentrate is freeze-dried to obtain natural polysaccharide.

[0040] Modification treatment: The natural polysaccharide was added into an ethanol aqueous solution with a mass concentration of 65%, and was modified by microwave-assisted reaction at 700 W for 45 min.

[0041] The modified polysaccharide solution is subjected to rotary evaporation to remove ethanol, thereby obtaining a modified polysaccharide solution.

[0042] Preparation of mouthwash solution: 7.5% of modified polysaccharide solution (calculated as natural polysaccharide), 0.07% of sodium fluoride, 0.1% of menthol, 7.5% of glycerol, 3.5% of ethanol and 0.7% of vitamin C were stirred and mixed uniformly according to the mass ratio.

[0043] 3% xanthan gum, 0.3% citric acid, 0.03% sodium benzoate and 0.015% sodium saccharin were added in proportion by mass, the mixture was made up to volume with water, and stirring was continued at a stirring speed of 4000 r / min for 15 min.

[0044] The uniformly mixed mouthwash solution is sterilized at high temperature (122°C for 17 seconds) to obtain a film-forming mouthwash solution based on natural polysaccharides. Example 4

[0045] Preparation of natural polysaccharides: The brown algae polysaccharide (seaweed polysaccharide) extracted from kelp and chitosan were soaked at a mass ratio of 10:1 at 60°C for 60 minutes, and then treated with a mechanical stirring speed of 1000 r / min and a 200 W ultrasonic wave for 30 minutes to obtain a natural polysaccharide suspension.

[0046] The natural polysaccharide suspension was preliminarily filtered through a microporous filter membrane with a pore size of 1 nm, and then the polysaccharides were further extracted using supercritical carbon dioxide extraction (temperature 35°C, pressure 25 MPa, extraction time 6 h).

[0047] The extracted polysaccharide solution is concentrated through a nanofiltration membrane to remove moisture; the concentrated solution is freeze-dried to obtain natural polysaccharides.

[0048] Modification treatment: The obtained natural polysaccharide was added into an ethanol aqueous solution with a mass concentration of 60%, and was modified by microwave-assisted reaction at 600 W for 30 min.

[0049] The modified polysaccharide solution is subjected to rotary evaporation to remove ethanol, thereby obtaining a modified polysaccharide solution.

[0050] Preparation of mouthwash solution: 5% of modified polysaccharide solution (calculated as natural polysaccharide), 0.1% of sodium fluoride, 0.2% of menthol, 10% of glycerol, 5% of ethanol and 1% of vitamin C were stirred and mixed uniformly according to the mass ratio.

[0051] 1% xanthan gum, 0.1% citric acid, 0.01% sodium benzoate and 0.01% sodium saccharin were added in proportion by mass, the volume was fixed with water, and stirring was continued at a stirring speed of 3000 r / min for 20 min.

[0052] The uniformly mixed mouthwash solution is sterilized at high temperature (121° C. for 20 seconds) to obtain a film-forming mouthwash solution based on natural polysaccharides. Example 5

[0053] Preparation of natural polysaccharides: The red algae polysaccharide extracted from Chondrus crispus and chitosan were soaked at a mass ratio of 10:6 at a temperature of 60°C to 80°C for 30 minutes, and then treated with a mechanical stirring speed of 1500 r / min and a 300 W ultrasonic wave for 20 minutes to obtain a natural polysaccharide suspension.

[0054] The natural polysaccharide suspension was preliminarily filtered through a microporous filter membrane with a pore size of 2 nm, and then the polysaccharides were further extracted using supercritical carbon dioxide extraction (temperature 45°C, pressure 35 MPa, extraction time 4 h).

[0055] The extracted polysaccharide solution is concentrated through a nanofiltration membrane to remove moisture; the concentrated solution is freeze-dried to obtain natural polysaccharides.

[0056] Modification treatment: The obtained natural polysaccharide was added into an ethanol aqueous solution with a mass concentration of 70%, and was modified by microwave-assisted reaction at 800 W for 60 min.

[0057] The modified polysaccharide solution is subjected to rotary evaporation to remove ethanol, thereby obtaining a modified polysaccharide solution.

[0058] Preparation of mouthwash solution: 10% modified polysaccharide solution (calculated as natural polysaccharide), 0.05% sodium fluoride, 0.05% menthol, 5% glycerol, 2% ethanol and 0.5% vitamin C were stirred and mixed uniformly according to the mass ratio.

[0059] Add 5% xanthan gum, 0.5% citric acid, 0.05% sodium benzoate and 0.02% sodium saccharin in proportion by mass, make up to volume with water, and continue stirring at a stirring speed of 5000 r / min for 10 min.

[0060] The uniformly mixed mouthwash solution is sterilized at high temperature (125°C for 15 seconds) to obtain a film-forming mouthwash solution based on natural polysaccharides. Example 6

[0061] Preparation of mouthwash solution: Stir and mix 7.5% pectin, 0.07% sodium fluoride, 0.1% menthol, 7.5% glycerol, 3.5% ethanol and 0.7% vitamin C according to the mass ratio.

[0062] 3% xanthan gum, 0.3% citric acid, 0.03% sodium benzoate and 0.015% sodium saccharin were added in proportion by mass, the mixture was made up to volume with water, and stirring was continued at a stirring speed of 4000 r / min for 15 min.

[0063] The uniformly mixed mouthwash solution is sterilized at high temperature (122°C for 17 seconds) to obtain a film-forming mouthwash solution based on natural polysaccharides. Example 7

[0064] The preparation of natural polysaccharide is the same as in Example 1 Preparation of mouthwash solution: 7.5% of modified polysaccharide solution (calculated as natural polysaccharide), 0.07% of sodium fluoride, 0.1% of menthol, 7.5% of glycerol, 3.5% of ethanol and 0.7% of vitamin C were stirred and mixed uniformly according to the mass ratio.

[0065] Add 0.3% citric acid, 0.03% sodium benzoate and 0.015% sodium saccharin in proportion by mass, make up to volume with water, and continue stirring at a stirring speed of 4000 r / min for 15 min.

[0066] The uniformly mixed mouthwash solution is sterilized at high temperature (122°C for 17 seconds) to obtain a film-forming mouthwash solution based on natural polysaccharides.

[0067] Comparative Example The basic formula and process are the same as those in Example 1, except that no corresponding amount of natural polysaccharides are added to the functional ingredients.

[0068] The film-forming performance and continuous protection time of the present invention are verified by the following experimental steps: The test results of each embodiment are shown in Table 1.

[0069] Table 1 Test results of film-forming mouthwash solution .

[0070] The longer the film-forming time, the more lasting the protective effect of the mouthwash in the oral cavity. G' (storage modulus) in Table 1 is a parameter used in rheology to describe the elastic behavior of materials, indicating the ability of materials to store energy during deformation. The higher the G' value, the stronger the elasticity of the material, the higher the mechanical strength of the film layer, and the better it can resist damage from external forces (such as chewing and swallowing). The clearance rate is the clearance rate of mutans streptococcus biofilm. The destruction time is the length of time it takes for the film layer to be destroyed when immersed in artificial saliva. The threshold reduction is the percentage of the reduction in the bitter perception threshold.

[0071] The film-forming mouthwash solution of the present invention can not only significantly improve the film-forming performance and continuous protection time of the mouthwash, but also effectively inhibit oral pathogens and provide good protection for the oral mucosa. It is an oral care product with broad application prospects.

[0072] The above is only a preferred embodiment of the present invention, and does not limit the present invention in other forms. Any technician familiar with the profession may use the above disclosed technical content to change or modify it into an equivalent embodiment with equivalent changes. However, any simple modification, equivalent change and modification made to the above embodiment according to the technical essence of the present invention without departing from the technical solution of the present invention still belongs to the protection scope of the technical solution of the present invention.

Claims

1. A film-forming mouthwash solution based on natural polysaccharides, comprising water, excipients and functional ingredients, characterized in that: The functional ingredients and their mass percentages in the mouthwash solution are: 5%-10% natural polysaccharide, 0.05%-0.1% sodium fluoride, 0.05%-0.2% menthol, 5%-10% glycerol, 2%-5% ethanol, and 0.5%-1% vitamin C.

2. The film-forming mouthwash solution based on natural polysaccharides according to claim 1, characterized in that: The auxiliary materials and their mass percentages in the mouthwash solution are: 1%-5% xanthan gum, 0.1%-0.5% citric acid, 0.01%-0.05% sodium benzoate and 0.01%-0.02% sodium saccharin.

3. The film-forming mouthwash solution based on natural polysaccharides according to claim 1, characterized in that: The preparation steps of the natural polysaccharide are: 1) Soak seaweed polysaccharide and chitosan at a mass ratio of 10:1-6 at a temperature of 60°C-80°C for 30min-60min, and then use ultrasonic treatment for 20min-30min while mechanically stirring to obtain a natural polysaccharide suspension; 2) The natural polysaccharide suspension is initially filtered through a microporous filter membrane, and then the polysaccharide is further extracted by supercritical carbon dioxide extraction; the extracted polysaccharide is concentrated through a nanofiltration membrane; the concentrate is freeze-dried to obtain the natural polysaccharide.

4. The film-forming mouthwash solution based on natural polysaccharides according to claim 3, characterized in that: The mechanical stirring speed in step 1) is 1000 r / min~1500 r / min, and the ultrasonic power of the ultrasonic treatment is 200 W~300 W.

5. The film-forming mouthwash solution based on natural polysaccharides according to claim 3, characterized in that In step 2), the conditions for supercritical carbon dioxide extraction are: temperature 35°C ~ 45°C, pressure 25 MPa ~ 35 MPa, and extraction time 4h ~ 6h.

6. The film-forming mouthwash solution based on natural polysaccharides according to claim 3, characterized in that: In step 2), the pore size of the nanofiltration membrane is 1 nm to 2 nm.

7. The film-forming mouthwash solution based on natural polysaccharides according to claim 3, characterized in that The obtained natural polysaccharide is added to an ethanol aqueous solution with a mass concentration of 60% to 70%, and modified by microwave-assisted reaction. The microwave power is 600W to 800W, and the reaction time is 30min to 60min. The polysaccharide solution after modification is evaporated to remove ethanol, thereby obtaining a modified polysaccharide solution. The obtained modified polysaccharide solution is used as the natural polysaccharide component of the film-forming mouthwash solution.

8. The film-forming mouthwash solution based on natural polysaccharides according to claim 1, characterized in that: The preparation steps include: firstly, mixing and stirring the functional ingredients evenly; then, adding auxiliary materials, and making up the volume with water, stirring and mixing evenly, and sterilizing the evenly mixed mouthwash solution by high temperature to obtain a film-forming mouthwash solution based on natural polysaccharides.

9. The film-forming mouthwash solution based on natural polysaccharides according to claim 8, characterized in that: The high temperature sterilization has a sterilization temperature of 121° C. to 125° C. and a time of 15 s to 20 s.