Post-art relieving composition suitable for sensitive skin, application and cosmetic

Abstract

The invention discloses a medical post-art relieving composition suitable for sensitive skin, application and cosmetics. The medical post-art relieving composition is prepared from red algae extract, trehalose and hostilochus atlantica oil, the mass ratio of the red algae extract to the trehalose to the hostianus atlantica oil is (0.1-5%): (0.1-3%): (0.1-10%). According to the post-medical-art relieving composition suitable for sensitive skin, the application and the cosmetics, the composition is formed by adding multiple functional components, the multiple components and multiple target points have a synergistic effect, even if part of the components are inactivated, the relieving effect of the composition can be guaranteed, and the post-medical-art relieving effect can be improved.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics and relates to a cosmetic, and in particular to a medical post-aesthetic soothing composition suitable for sensitive skin, an application thereof, and a cosmetic. Background Art

[0002] The "Guidelines for Clinical Diagnosis and Treatment of Sensitive Skin in China" (2024 edition) defines sensitive skin as a syndrome in which the skin experiences paroxysmal or periodic burning, paroxysmal redness, tingling, itching, and tightness, with or without persistent erythema, after being slightly stimulated by the outside world. Environmental and climate changes, psychological stress, etc. can induce skin sensitivity. Under the interaction of internal and external factors, impaired skin barrier function causes an increase in sensory nerve conduction signals, resulting in increased skin reactivity to external stimuli and an inflammatory response. At present, the general treatment principles are to promote skin barrier repair, reduce inflammatory responses, and reduce neurovascular hyperreactivity.

[0003] The skin barrier is the first line of defense for the human body. The transepidermal water loss (TWEL) of sensitive skin increases, the water content of the stratum corneum decreases, and the expression of tight junction protein 5 (CLDN5) decreases, resulting in an incomplete tight junction (TJ) structure, indicating that the barrier function of sensitive skin is impaired. When the skin barrier function is impaired, the permeability of the skin increases, and external chemicals, antigens, and microorganisms are more likely to invade the skin, causing an inflammatory response. At the same time, the skin's protective effect on dermal nerves and blood vessels is weakened, which in turn promotes the occurrence of sensitive skin.

[0004] When the skin barrier is damaged, the protection of skin nerve endings and blood vessels is reduced. High temperature, acidic environment, capsaicin, ultraviolet rays and exogenous inflammatory mediators activate transient receptor potential vanilloid subtype 1 receptor (TRPV-1) and thermal and chemical stimulation sensory input, causing symptoms such as burning, paroxysmal redness, pain, and itching. In addition, TRPV-1 causes mast cells to secrete endothelin (ET), ET-1 induces the secretion of tumor necrosis factor (TNF)-α and interleukin (IL)-6, and promotes the production of vascular endothelial growth factor (VEGF), which increases vascular reactivity and induces vasodilation. At present, skin barrier repair is mainly carried out by supplementing physiological lipids such as ceramide, cholesterol and free fatty acids; adding moisturizing ingredients such as glycerol, hyaluronic acid, polyols, etc.

[0005] TRPV-1 induces mast cell degranulation and promotes the release of neurotransmitters, such as vasoactive substances intestinal polypeptide (VIP), substance P (SP) and calcitonin gene-related polypeptide (CGRP), triggering neurogenic inflammatory response. ET-1 can also promote the release of IL-23 and IL-31 by keratinocytes and mast cells near sensory nerve endings, and activate antigen presenting cells and T lymphocytes, IL-1, IL-8, TNF and prostaglandins PGE2 and PGF2, thereby triggering skin immune inflammatory response. Therefore, inhibiting the oversensitization of TRPV-1 receptor function plays an important role in improving skin sensitivity. The commonly used TRPV1 antagonist in cosmetics is trans-4-tert-butyl cyclohexanol, which increases the tolerance threshold of the skin by reducing the flow of calcium ions in the cell membrane.

[0006] With the steady increase in national disposable income, under the dual influence of consumption upgrading and new digital media marketing, consumers' acceptance of medical beauty has gradually increased, and the medical beauty market has increased significantly. Medical cosmetology refers to the use of drugs, surgery, medical devices and other invasive or irreversible medical techniques to repair and reshape the appearance and shape of various parts of the human body. Although the skin is prone to sensitivity after medical beauty, some medical beauty projects such as phototherapy and Thermage can stimulate the regeneration of collagen in the dermis and thicken the epidermis, thereby enhancing the skin's resistance to external bacteria, pollutants, etc., and improving skin sensitivity.

[0007] First of all, the current inventions in the field of post-aesthetic soothing in medical art, such as the Chinese invention patent CN202110428151.7, only have moisturizing and soothing effects, and cannot prevent the damage of the exposed group to the skin. The exposed group directly acts on the skin, which will cause skin damage and aging, and then cause skin sensitivity. Therefore, conventional post-aesthetic soothing products in medical art cannot meet the advanced soothing needs of sensitive skin.

[0008] Secondly, there are currently many inventions for soothing sensitive skin or soothing after medical aesthetics, which mainly achieve the soothing effect by adding soothing ingredients; when applying them to cosmetics, additional emulsifiers still need to be added, and there is a risk of emulsifiers irritating the stratum corneum and native sebum membrane.

[0009] Finally, current research on medical post-aesthetic relief, such as Chinese invention patent CN202311391671.0, has shortcomings such as single effective ingredients, poor ingredient stability, and limited usage conditions.

[0010] In view of this, there is an urgent need to design a new soothing cosmetic after medical aesthetics to overcome at least some of the above-mentioned defects of existing soothing cosmetics after medical aesthetics. Summary of the invention

[0011] The present invention provides a medical post-aesthetic soothing composition and application and cosmetics suitable for sensitive skin. The composition is formed by adding multiple functional ingredients, and the multiple ingredients and multiple targets act synergistically. Even if some ingredients are inactivated, the soothing efficacy of the composition can be guaranteed, thereby improving the soothing effect of medical post-aesthetics.

[0012] To solve the above technical problem, according to one aspect of the present invention, the following technical solution is adopted:

[0013] A medical post-aesthetic soothing composition suitable for sensitive skin, the medical post-aesthetic soothing composition comprising: red algae extract, trehalose and Atlantic snapper oil; the mass ratio of the red algae extract, trehalose and Atlantic snapper oil is (0.1-5%): (0.1-3%): (0.1-10%).

[0014] As an embodiment of the present invention, the mass ratio of the red algae extract, trehalose and Atlantic snapper oil is (0.1-3%): (0.1-2%): (0.1-5%).

[0015] According to another aspect of the present invention, the following technical solution is adopted: an application of the above-mentioned medical post-art soothing composition suitable for sensitive skin in the preparation of cosmetics with damaged skin repairing effect.

[0016] According to another aspect of the present invention, the following technical solution is adopted: an application of the above-mentioned cosmetics with damaged skin repairing effect, wherein the medical cosmetic surgery includes at least one of photorejuvenation, fractional laser, and laser hair removal.

[0017] According to another aspect of the present invention, the following technical solution is adopted: a cosmetic comprising the above-mentioned medical post-art soothing composition suitable for sensitive skin.

[0018] As an embodiment of the present invention, the cosmetic is an essence, a cream, an emulsion, a freeze-dried powder, or a skin care lotion.

[0019] As an embodiment of the present invention, the cosmetic is an essence, and the essence includes a soothing composition, a raw material combination A, a raw material combination B, a raw material combination C and a raw material combination D;

[0020] Based on 100 parts by weight of the essence, the essence comprises 0.3 to 15 parts of a soothing composition, 1.2 to 75 parts of a raw material combination A, 1.2 to 75 parts of a raw material combination B, 0.1 to 5 parts of a raw material combination C, and 0.11 to 6 parts of a raw material combination D;

[0021] The soothing composition comprises 0.1 to 5 parts of red algae extract, 0.1 to 3 parts of trehalose, and 0.1 to 10 parts of Atlantic seabream oil; the raw material combination A comprises 0.1 to 25 parts of thickener A, 0.1 to 30 parts of skin conditioner A, and 1 to 30 parts of moisturizer A; the raw material combination B comprises 0.1 to 25 parts of thickener B, 0.1 to 30 parts of emulsifier, and 1 to 25 parts of skin conditioner B; the raw material combination C comprises 0.1 to 5 parts of pH regulator; the raw material combination D comprises 0.1 to 5 parts of fragrance and 0.01 to 1 part of preservative.

[0022] As an embodiment of the present invention, the raw material combination A further comprises water, and the volume of the water is such that the weight parts of the essence reaches 100 parts;

[0023] The thickener A and the thickener B each independently include at least one of acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, polyacrylamide, xanthan gum, propylene glycol, behenyl alcohol, carbomer, laureth-7, cetyl alcohol, stearyl alcohol and hydroxyethyl cellulose;

[0024] The skin conditioning agent A and the skin conditioning agent B each independently include at least one of glycerin, isohexadecane, olive oil, sodium hyaluronate, lauryl alcohol, avocado butter, allantoin, butylene glycol, squalane, panthenol, lactic acid, tocopherol and dipotassium glycyrrhizinate;

[0025] The moisturizing agent A comprises at least one of hyaluronic acid, allantoin, glycerin, ceramide, sodium lactate, butylene glycol, ethylhexylglycerin, hydrogenated grape seed oil, olive oil and shea butter;

[0026] The emulsifier includes at least one of glyceryl stearate citrate, cetearyl glucoside (and) cetearyl alcohol, behenyl trimethyl ammonium methyl sulfate, cocoglycerides and sorbitan olivate;

[0027] The pH adjuster includes at least one of arginine and lactic acid;

[0028] The aromatic agent includes essence;

[0029] The preservative includes at least one of phenoxyethanol, ethylhexylglycerin and pentylene glycol.

[0030] The beneficial effects of the present invention are as follows: the medical post-aesthetic soothing composition and application and cosmetics suitable for sensitive skin proposed by the present invention form a composition by adding multiple functional ingredients, and the multi-component and multi-target synergistic effects can ensure the soothing effect of the composition even if some of the ingredients are inactivated, thereby improving the medical post-aesthetic soothing effect.

[0031] The composition of the present invention achieves the purpose of soothing through the synergistic effects of hydrolyzed red algae extract, trehalose and Atlantic snapper oil to increase the water-locking capacity of keratinocytes, reduce water evaporation, fill intercellular lipids, reduce the release of inflammatory factors, prevent exposure group damage and other pathways.

[0032] In one usage scenario of the present invention, the present invention induces an increase in telomerase activity through the synergistic effect of hydrolyzed red algae extract and Atlantic snapper oil, inhibits telomere damage in the exposure group, and simultaneously increases the skin's protection against UVB, preventing damage to the skin and aggravation of skin sensitivity caused by external environmental exposure, thereby meeting the soothing needs of sensitive skin after medical aesthetics.

[0033] The present invention achieves the purpose of soothing by increasing the water-locking capacity of keratinocytes, reducing water evaporation, filling intercellular lipids, reducing the release of inflammatory factors, and preventing damage to the exposed group. By optimizing the combination of raw materials, the multi-target synergistic effect of the composition is achieved, ensuring that the efficacy of the composition can be stably exerted under various conditions of use, and the combined use is significantly better than the effect of each component used alone.

[0034] The present invention emphasizes the emulsification effect of trehalose, and stabilizes the emulsion and reduces the amount of emulsifier by improving the interfacial compatibility between heterogeneous phases. When the composition is applied to cosmetics, the amount of emulsifier can be reduced, the risk of cosmetics irritating the stratum corneum and native sebum membrane of the skin can be reduced, and the cost of raw materials can be reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 This is a schematic diagram of the changing trend of the skin a value after using the embodiment, control example and positive control example after medical aesthetics. DETAILED DESCRIPTION

[0036] The preferred embodiments of the present invention are described in detail below with reference to the accompanying drawings.

[0037] In order to further understand the present invention, preferred embodiments of the present invention are described below in conjunction with examples. However, it should be understood that these descriptions are only for further illustrating the features and advantages of the present invention, rather than limiting the claims of the present invention.

[0038] The description in this section is only for several typical embodiments, and the present invention is not limited to the scope of the embodiments. The same or similar prior art means and some technical features in the embodiments are mutually replaced within the scope of the present invention.

[0039] Unless otherwise indicated, implied from the context, or customary in the prior art, all parts and percentages in this application are based on weight, and the test and characterization methods used are all current as of the filing date of this application. Where applicable, the contents of any patent, patent application or publication referred to in this application are fully incorporated herein by reference, and their equivalent patent families are also incorporated by reference, especially the definitions of synthesis techniques, product and processing designs, polymers, comonomers, initiators or catalysts disclosed in these documents in the art. If the definition of a specific term disclosed in the prior art is inconsistent with any definition provided in this application, the definition of the term provided in this application shall prevail.

[0040] Numerical ranges in this application are approximate values, so unless otherwise specified, they may include numerical values ​​outside the range. Numerical ranges include all numerical values ​​from the lower limit to the upper limit increased by 1 unit, provided that there is an interval of at least 2 units between any lower value and any higher value. For example, if the recorded component, physical or other properties (such as molecular weight, melt index, etc.) are 100 to 1000, it means that all single values ​​are clearly listed, such as 100, 101, 102, etc., and all sub-ranges, such as 100 to 166, 155 to 170, 198 to 200, etc. For a range containing a numerical value less than 1 or containing a fraction greater than 1 (such as 1.1, 1.5, etc.), 1 unit is appropriately regarded as 0.0001, 0.001, 0.01 or 0.1. For a range containing a single digit less than 10 (such as 1 to 5), 1 unit is usually regarded as 0.1. These are only specific examples of what is intended to be expressed, and all possible combinations of values ​​between the lowest and highest values ​​listed are considered to be clearly recorded in this application. It should also be noted that the terms "first", "second", etc. in this article do not limit the order of precedence, but are only used to distinguish substances with different structures.

[0041] When used with respect to chemical compounds, unless expressly specified otherwise, the singular includes all isomeric forms and vice versa (e.g., "hexane" includes all isomers of hexane, individually or collectively). In addition, nouns using "a," "an," or "the" also include their plural forms unless expressly specified otherwise.

[0042] The terms "comprising", "including", "having" and their derivatives do not exclude the presence of any other components, steps or processes, and are irrelevant to whether these other components, steps or processes are disclosed in this application. To eliminate any doubt, unless explicitly stated, all compositions using the terms "comprising", "including", or "having" in this application may include any additional additives, adjuvants or compounds. On the contrary, except for those necessary for operating performance, the term "essentially consisting of..." excludes any other components, steps or processes from the scope of any description of the term below. The term "consisting of..." does not include any components, steps or processes that are not specifically described or listed. Unless explicitly stated, the term "or" refers to the listed individual members or any combination thereof.

[0043] The description of the steps in each embodiment in the specification is only for the convenience of explanation, and the implementation method of the present application is not limited by the order of implementation of the steps.

[0044] The present invention discloses a medical post-aesthetic soothing composition suitable for sensitive skin, the medical post-aesthetic soothing composition comprising: red algae extract, trehalose and Atlantic snapper oil; the mass ratio of the red algae extract, trehalose and Atlantic snapper oil is (0.1-5%): (0.1-3%): (0.1-10%). In one embodiment of the present invention, the mass ratio of the red algae extract, trehalose and Atlantic snapper oil is (0.1-3%): (0.1-2%): (0.1-5%).

[0045] The present invention further discloses an application of the above-mentioned medical post-sun soothing composition suitable for sensitive skin in the preparation of cosmetics with after-sun repair effect. Medical cosmetic surgery includes at least one of photorejuvenation, fractional laser, and laser hair removal.

[0046] Hydrolyzed red algae extract is a bioactive component extracted, purified and degraded from marine red algae, mainly including galactose in the cell wall of red algae, glucan in the cytoplasm, mannan and xylan that make up the cell wall, etc. Red algae polysaccharides can significantly inhibit the release of TNF-α, IL-1β and the expression of TRPV1 and neurokinin 1 (NK1-R), reduce the synthesis of VEGF, and at the same time increase the release of β-endorphin in inflammatory tissues. Through the synergistic effect of multiple targets, it can achieve the effects of anti-inflammatory, analgesia, reducing redness, and soothing the skin.

[0047] The exposome is a concept proposed by Dr. Christopher Wild, a cancer pathologist, in 2005. It refers to the sum of various exposures from a person's embryo to the end of life. The exposome is divided into external environmental exposure: urban environment, ultraviolet rays, pollution, climate factors, stress, blue light (380-500nm); special external environmental exposure: infection, radiation, lifestyle (drinking, tobacco), eating habits, physical activities, etc. and internal environmental exposure: such as metabolism, hormones, microbial systems, inflammation, oxidative stress, etc. Compared with genetic factors, exposome factors are more likely to cause telomere damage and activation of signaling pathways such as mTOR. Telomere shortening is the main sign of aging. Telomere length shortens with age. The activity level of telomerase is an important factor in determining telomere length in cells and tissues. In particular, hydrolyzed red algae extract can induce increased telomerase activity and increase the thickness of the skin surface, thereby inhibiting the harmful effects of the exposome on the skin.

[0048] Trehalose is a non-reducing sugar, and its unique molecular structure makes it have good stability at extreme pH and temperature. Trehalose can work together to achieve moisturizing and nourishing effects by increasing the water-locking ability of keratinocytes, reducing water evaporation, filling intercellular lipids, and improving lamellar structures, thereby reducing the release of inflammatory factors IL-6 caused by dry skin, preventing inflammatory reactions, and reducing skin itching. In particular, the natural gel network structure of trehalose can improve the interfacial compatibility between heterogeneous phases, effectively prevent reaggregation between dispersed phases, stabilize emulsions, and reduce the amount of emulsifiers used. Reducing emulsifiers helps reduce the risk of cosmetics irritating the stratum corneum and native sebum membrane of the skin.

[0049] Atlantic bream oil is an effective ingredient obtained through a series of processes such as deoxygenation, decolorization, and selective hydrogenation. Oils with a certain degree of unsaturation have better repair effects on the skin than fully saturated oils. Therefore, selective hydrogenation can provide better touch and efficacy while improving the stability of oils. Atlantic bream oil can replenish intercellular lipids and increase the water content of the stratum corneum. It is rich in ω-3 polyunsaturated fatty acids (ω-3PUFAs), which can absorb UVB and prevent external exposure to the environment. It works synergistically with the first two effective ingredients described in the present invention to replenish water and moisturize. The joint action of multiple targets inhibits the damage to the skin of the exposed group, while reducing the inflammatory response of sensitive skin, thereby soothing the skin.

[0050] The present invention also discloses a cosmetic, which comprises the above-mentioned medical post-art soothing composition suitable for sensitive skin. The cosmetic can be an essence, a cream, an emulsion, a freeze-dried powder or a skin care lotion.

[0051] In one embodiment of the present invention, the cosmetic is an essence, and the essence comprises a soothing composition, a raw material combination A, a raw material combination B, a raw material combination C, and a raw material combination D. Based on 100 parts by weight of the essence, the essence comprises 0.3 to 15 parts of the soothing composition, 1.2 to 75 parts of the raw material combination A, 1.2 to 75 parts of the raw material combination B, 0.1 to 5 parts of the raw material combination C, and 0.11 to 6 parts of the raw material combination D.

[0052] The soothing composition comprises 0.1 to 5 parts of red algae extract, 0.1 to 3 parts of trehalose, and 0.1 to 10 parts of Atlantic seabream oil; the raw material combination A comprises 0.1 to 25 parts of thickener A, 0.1 to 30 parts of skin conditioner A, and 1 to 30 parts of moisturizer A; the raw material combination B comprises 0.1 to 25 parts of thickener B, 0.1 to 30 parts of emulsifier, and 1 to 25 parts of skin conditioner B; the raw material combination C comprises 0.1 to 5 parts of pH regulator; the raw material combination D comprises 0.1 to 5 parts of fragrance and 0.01 to 1 part of preservative.

[0053] In one embodiment, the thickener A and the thickener B each independently include at least one of acrylic acid (esters) / C10-30 alkyl acrylate crosspolymer, polyacrylamide, xanthan gum, propylene glycol, behenyl alcohol, carbomer, laureth-7, cetyl alcohol, stearyl alcohol and hydroxyethyl cellulose.

[0054] The skin conditioning agent A and the skin conditioning agent B each independently include at least one of glycerin, isohexadecane, olive oil, sodium hyaluronate, lauryl alcohol, shea butter, allantoin, butylene glycol, squalane, panthenol, lactic acid, tocopherol and dipotassium glycyrrhizinate.

[0055] The moisturizer A includes at least one of hyaluronic acid, allantoin, glycerin, ceramide, sodium lactate, butylene glycol, ethylhexylglycerin, hydrogenated grape seed oil, olive oil and shea butter.

[0056] The emulsifier includes at least one of glyceryl stearate citrate, cetearyl glucoside (and) cetearyl alcohol, behentrimonium methylsulfate, cocoglycerides and sorbitan olivate.

[0057] The pH adjuster includes at least one of arginine and lactic acid.

[0058] The aromatic agent includes essence.

[0059] The preservative includes at least one of phenoxyethanol, ethylhexylglycerin and pentylene glycol.

[0060] The present invention further discloses a method for preparing a medical post-aesthetic soothing essence suitable for sensitive skin, the preparation method comprising:

[0061] [Step a] Obtaining an aqueous phase: placing water in a container equipped with a stirring device, fully moistening and mixing the other parts of the raw material combination A except water, adding them into the water, stirring thoroughly until completely dissolved, and heating;

[0062] [Step b] Obtaining the oil phase: Mix and heat the raw material combination B, and stir until completely dissolved.

[0063] [Step c] Emulsification step: add the mixture of step b to the aqueous phase of step a, and stir and homogenize for a set time;

[0064] In one embodiment, the mixture of step b is added to the aqueous phase of step a, and stirred and homogenized for 3 to 10 minutes (eg, 5 minutes).

[0065] [Step d] Add raw material combination C, stir and homogenize for a set time; stir and cool to 40-45°C;

[0066] In one embodiment, raw material combination C is added, stirred at 250-350 rpm for 3-5 minutes and homogenized at 2500-3500 rpm for 3-10 minutes; stirred and cooled to 45°C.

[0067] [Step e] Add the post-aesthetic soothing composition, stir and homogenize for a set time;

[0068] In one embodiment, the post-art soothing composition is added, stirred at 250-350 rpm for 3-5 minutes and homogenized at 2500-3500 rpm for 3-10 minutes.

[0069] [Step f] After stirring and cooling to 35-38°C, add raw material combination D, stir and homogenize for a set time to obtain the desired post-aesthetic soothing cosmetics suitable for sensitive skin.

[0070] In one embodiment, after stirring and cooling to 35-38° C., raw material combination D is added, stirred at 250-350 rpm and homogenized at 2500-3500 rpm for 3-10 minutes; before filling, the mixture is filtered and sterilized, and the bacterial content is tested and quality control is performed on toxins, immunogenicity, etc. to obtain the desired medical post-aesthetic soothing essence suitable for sensitive skin.

[0071] The heating temperature in steps a to b may be 75 to 80° C.; the stirring speed in steps c to f may be 200 to 400 rpm; and the homogenizing speed in steps c to f may be 2000 to 4000 rpm.

[0072] The present invention uses essence as an example to set up each group of experiments, but is not limited to the use of essence. The composition can also be applied to various skin care products such as lotions, creams, freeze-dried powders, and skin care water. The essence is the above key combination and emollients, thickeners, chelating agents, and pH regulators. Preferably, the raw materials for preparing the medical post-aesthetic soothing essence suitable for sensitive skin also include any one or a combination of at least two of preservatives and fragrances.

[0073] Table 1 Proportions of components in Example 1

[0074]

[0075]

[0076] In one embodiment of the present invention, the method for preparing the essence comprises the following steps:

[0077] a. Water phase: Place water in a container with a stirring device, fully wet and mix the other parts of the raw material combination A, add them into the water, stir thoroughly until completely dissolved, and heat.

[0078] b. Oil phase: Mix raw material combination B, heat and stir until completely dissolved.

[0079] c. Emulsification: Add the mixture from step b to the aqueous phase from step a, and stir and homogenize for 5 minutes.

[0080] d. Add raw material C, stir and homogenize for 3 minutes. Stir and cool to 45℃.

[0081] e. Add ingredient combination D, stir and homogenize for 3 minutes.

[0082] f. After stirring and cooling to 35-38℃, add raw material combination E, stir and homogenize for 3 minutes, filter and sterilize before filling, test the bacterial content and perform quality control on toxins and immunogenicity to obtain the desired medical post-aesthetic soothing essence suitable for sensitive skin.

[0083] The heating temperature in steps a to b is 75 to 80° C.; the stirring speed in steps c to f is 200 to 400 rpm; and the homogenizing speed in steps c to f is 2000 to 4000 rpm.

[0084] Characterization data and effect data of the products of the embodiments and comparative examples

[0085] Examples 2-3 and Comparative Examples 1-3

[0086] The difference between Example 2 and Example 3 and Example 1 is only that each active ingredient is reduced.

[0087] The difference between Control Examples 1-3 and Example 1 is the lack of one key composition component, the difference between Control Examples 4-6 and Example 1 is the lack of two key composition components, and the difference between Control Example 7 and Example 1 is that no composition component is added.

[0088] The specific proportions of Examples 2-3 and Comparative Examples 1-3 are shown in Table 2, and the preparation method is the same as that of Example 1.

[0089] Table 2 Specific proportions of components in Examples 1-3 and Comparative Examples 1-7

[0090]

[0091]

[0092] Efficacy evaluation test

[0093] 110 female volunteers aged between 18 and 45 years old, who had recently completed laser cosmetic projects (photorejuvenation, fractional laser, laser hair removal) and had similar skin redness and swelling conditions, were selected for the following efficacy test.

[0094] 1. Test on the change rate of moisture content in the stratum corneum over time and the change rate of transepidermal water loss (TWEL)

[0095] 110 female volunteers were randomly divided into 11 groups, each group corresponding to 10 people, and each group used the essence obtained in Examples 1-3 and the essence obtained in Control Examples 1-7 in the morning and evening, respectively, and the positive control group used a commercially available soothing and repairing ointment, once in the morning and evening every day, for a total of 28 days.

[0096] Test equipment: TWEL( Combo), Corneometer CM825;

[0097] Test results:

[0098] (1) Statistics of adverse events during the test: None

[0099] (2) The results of skin physicochemical data analysis are shown in Tables 3 and 4.

[0100] Table 3 Changes of moisture content in the stratum corneum of the subjects over time

[0101]

[0102]

[0103] As can be seen from Table 3, after using the essence, the water content of the stratum corneum of Examples 1-3, the positive control group and Control Examples 1-7 all improved over time. Among them, the improvements in Examples 1-3 and the positive control group were particularly significant. Specifically, the rate of change in the water content of the stratum corneum of the skin reached 16.11% after 7 days of use in Example 1, and increased to 33.26% after 28 days, which was equivalent to 26.68% in the positive control group after 28 days, and the effect was better, without drug dependence, reflecting the high efficiency and safety of the present invention. Under the condition of reducing the content of the active ingredient, Examples 2 and 3 can still maintain an improvement effect that is better than the positive control group, further verifying the effectiveness and formula flexibility of the present invention.

[0104] Further comparing Example 3 with Control Examples 1-7, the control examples lack one or more key ingredients, and the change rate of the moisture content of the stratum corneum of the skin is significantly lower than that of the examples. Specifically, the improvement effect of Control Examples 1-3 (lacking red algae extract, trehalose or Atlantic bream oil, respectively) is significantly weakened compared with the examples containing these three ingredients at the same time, while the effects of Control Examples 4-6 (lacking two of the ingredients) and Control Example 7 (no composition ingredients are added at all) are even worse, proving the synergistic effect between the hydrolyzed red algae extract, trehalose and Atlantic bream oil, that is, the simultaneous use of these three ingredients can significantly increase the moisture content of the stratum corneum and show a stronger barrier repair effect.

[0105] Table 4 Analysis of the change rate of transepidermal water loss (TWEL) of subjects

[0106]

[0107]

[0108] As can be seen from Table 4, after using the essence, the transepidermal water loss (TWEL) of Examples 1-3, the positive control group and the control examples 1-7 all improved over time. By comparing the change rate of transepidermal water loss (TWEL) of Examples 1-3 and the positive control group, it can be clearly seen that Examples 1-3 have advantages in improving skin barrier function. Specifically, Example 1 showed a significant decrease in TWEL (-8.17%) after 7 days of use, and achieved an improvement of -22.13% after 28 days. Compared with the -19.89% of the positive control group after 28 days, Example 1 had a better effect. Furthermore, Examples 2 and 3 reduced the concentration of the active ingredient and still maintained an improvement effect that was better than the positive control group, further demonstrating the high efficiency and formulation flexibility of the present invention.

[0109] Further comparing Example 3 with Control Examples 1-7, Control Examples 1-3 lack one of the red algae extract, trehalose or Atlantic bream oil, respectively, and their TWEL improvement effect is significantly lower than that of the embodiment, indicating that these ingredients each play an important role in maintaining the skin barrier function. Control Examples 4-6 lack two of the key ingredients, and their effect is further weakened, while Control Example 7 does not add any composition ingredients at all, and the improvement effect is the most limited, proving that there is a synergistic effect between the hydrolyzed red algae extract, trehalose and Atlantic bream oil. The simultaneous use of these three ingredients can more significantly reduce transepidermal water loss, effectively enhance the skin barrier function, and has significant advantages in soothing and repairing sensitive skin after medical aesthetics.

[0110] 2. Skin redness a* value test

[0111] 110 female volunteers were randomly divided into 11 groups, each group corresponding to 10 people, and each group used the essence obtained in Examples 1-3 and the essence obtained in Control Examples 1-7 in the morning and evening, respectively, and the positive control group used a commercially available soothing and repairing ointment, once in the morning and evening every day, for a total of 28 days.

[0112] Testing instrument: Skin color measuring instrument CL400

[0113] Test results: Skin color, the higher the a* value, the redder the skin color and the more severe the swelling;

[0114] (1) Statistics of adverse events during the test: None

[0115] (2) The results of skin physicochemical data analysis are shown in Table 5.

[0116] Table 5 Change rate of skin redness a* value of subjects

[0117]

[0118]

[0119] As can be seen from the data in Table 5, Examples 1-3 have significant advantages in improving skin redness and swelling. After 7 days of use, the skin redness a value of Example 1 decreased by 6.81%, and continued to improve in the subsequent test cycle, ultimately reaching a significant decrease of 19.01%. Even though Examples 2 and 3 reduced the concentration of the active ingredient, their soothing and redness-removing effects were still better than the positive control group, indicating that the composition of the present invention has high efficiency and stability within the effective concentration range.

[0120] Further comparing Example 3 with Control Examples 1-7, Control Examples 1-3 lack one of the components in red algae extract, trehalose or Atlantic snapper oil, and the improvement effect of the skin redness a* value is significantly lower than that of Examples 1-3. In particular, Example 1, after 28 days of use, its improvement effect far exceeded that of the control example, proving that these three ingredients have a synergistic effect in reducing skin redness and swelling. Control Examples 4-6 lack two of the key ingredients, and their effects are further weakened, while Control Example 7 does not add any composition ingredients at all, and the improvement effect is the most limited. These results fully demonstrate the synergistic effect of hydrolyzed red algae extract, trehalose and Atlantic snapper oil when used in combination. They work together on the skin to more significantly reduce skin redness and swelling, providing a more effective and stable solution for after-care of sensitive skin medical aesthetics. Please refer to Figure 1 .

[0121] 3. In vitro TNF-α inflammatory factor content determination LPS-induced macrophage RAW264.7 test

[0122] Experimental model: Mouse mononuclear macrophage leukemia cell line RAW264.7

[0123] Test sample: 0.02% of samples obtained from Examples 1-3 and Comparative Examples 1-7

[0124] Positive control group: 100 μg / mL dexamethasone

[0125] Test method:

[0126] (1) Cytotoxicity test: Determine the most appropriate sample concentration through cytotoxicity test;

[0127] (2) Cell inoculation: Dilute cells with cell culture medium to the inoculation density (the degree of confluence reaches 45%-60% 24 h after inoculation), inoculate into 96-well plates, 200 μL per well, and culture in a CO2 incubator for 24±2 h;

[0128] (3) Administration: Discard the culture medium in the 96-well plate and carry out induction and administration. Add culture medium containing a certain concentration of the test substance and LPS to the test wells, add cell culture medium containing LPS to the negative control wells, add culture medium containing positive control and LPS to the positive control wells, and add cell culture medium to the blank / solvent control wells, 200 μL per well. After administration, place the 96-well plate in a CO2 incubator for 24 h ± 2 h;

[0129] (4) Collection of cell supernatant: After the incubation, collect the cell supernatant into a 1.5 ml sterile centrifuge tube and store it in a -80°C refrigerator;

[0130] (5) ELISA test pre-experiment: Because the expression of TNF-α is high after LP induction, the dilution ratio should be set and a pre-experiment should be conducted before the formal test to determine the dilution ratio of the ELISA test group to ensure that the ELISA test value falls within the range of the standard curve;

[0131] (6) ELISA test: Perform the test according to the operating instructions of the TNF-α ELISA test kit

[0132] The calculation formula of TNF-α inhibition rate: Inhibition rate (%) = (1-T / C) × 100%

[0133] Wherein, T is the average TNF-α content of the test substance, and C is the average TNF-α content of the negative control.

[0134] Table 6 Type I TNF-α content results

[0135] Sample name TNF-α content results TNF-α content inhibition rate Blank / Solvent Control 26.78 - Negative control 185.32 - Positive Control 65.66 64.57％ 0.02% Example 1 98.75 46.71％ 0.02% Example 2 116.37 37.20％ 0.02% Example 3 123.21 33.52％ 0.02% Control Example 1 140.79 24.03％ 0.02% Control Example 2 142.32 23.20％ 0.02% Control Example 3 135.63 26.81％ 0.02% Control Example 4 157.85 14.82％ 0.02% Control Example 5 159.32 14.03％ 0.02% Control Example 6 155.75 15.96％ 0.02% Control Example 7 175.36 5.37％

[0136] As can be seen from Table 6, the inhibition rate of TNF-α content in the positive control is ≥25%, and the test system is effective. Compared with the blank control, the TNF-α content of the negative control under the action of LSP is increased by ≥5 times, and the stimulation conditions meet the test requirements. Compared with the negative control, the inhibition rate of TNF-α content in Examples 1-3 is significantly different, indicating that the sample has the ability to inhibit TNF-α content, which can further illustrate that the sample has a soothing effect, among which Example 1 has the strongest inhibitory effect on TNF-α; compared with Control Examples 1-7, Example 1-3 has a more significant inhibitory effect on TNF-α, indicating that the composition of hydrolyzed red algae extract, trehalose and Atlantic snapper oil has a synergistic effect, and the essence prepared from the composition has a stronger ability to inhibit TNF-α.

[0137] In summary, the medical post-aesthetic soothing composition and application and cosmetics suitable for sensitive skin proposed in the present invention form a composition by adding multiple functional ingredients, and the multi-component and multi-target synergistic effects can ensure the soothing effect of the composition even if some of the ingredients are inactivated, thereby improving the soothing effect of medical post-aesthetics.

[0138] The composition of the present invention achieves the purpose of soothing through the synergistic effects of hydrolyzed red algae extract, trehalose and Atlantic snapper oil to increase the water-locking capacity of keratinocytes, reduce water evaporation, fill intercellular lipids, reduce the release of inflammatory factors, prevent exposure group damage and other pathways.

[0139] In one usage scenario of the present invention, the present invention induces an increase in telomerase activity through the synergistic effect of hydrolyzed red algae extract and Atlantic snapper oil, inhibits telomere damage in the exposure group, and simultaneously increases the skin's protection against UVB, preventing damage to the skin and aggravation of skin sensitivity caused by external environmental exposure, thereby meeting the soothing needs of sensitive skin after medical aesthetics.

[0140] The present invention achieves the purpose of soothing by increasing the water-locking capacity of keratinocytes, reducing water evaporation, filling intercellular lipids, reducing the release of inflammatory factors, and preventing damage to the exposed group. By optimizing the combination of raw materials, the multi-target synergistic effect of the composition is achieved, ensuring that the efficacy of the composition can be stably exerted under various conditions of use, and the combined use is significantly better than the effect of each component used alone.

[0141] The present invention emphasizes the emulsification effect of trehalose, and stabilizes the emulsion and reduces the amount of emulsifier by improving the interfacial compatibility between heterogeneous phases. When the composition is applied to cosmetics, the amount of emulsifier can be reduced, the risk of cosmetics irritating the stratum corneum and native sebum membrane of the skin can be reduced, and the cost of raw materials can be reduced.

[0142] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0143] The description and application of the present invention here are illustrative, and it is not intended to limit the scope of the present invention to the above-mentioned embodiments. The effects or advantages involved in the embodiments may not be embodied in the embodiments due to interference from various factors, and the description of the effects or advantages is not used to limit the embodiments. The deformation and change of the embodiments disclosed here are possible, and the replacement of the embodiments and the various equivalent parts are well known to those of ordinary skill in the art. It should be clear to those skilled in the art that the present invention can be implemented in other forms, structures, arrangements, proportions, and with other components, materials and parts without departing from the spirit or essential features of the present invention. Other deformations and changes can be made to the embodiments disclosed here without departing from the scope and spirit of the present invention.

Claims

1. A medical post-art soothing composition suitable for sensitive skin, characterized in that: The medical post-art soothing composition comprises: red algae extract, trehalose and Atlantic snapper oil; The mass ratio of the red algae extract, trehalose and Atlantic snapper oil is (0.1-5%): (0.1-3%): (0.1～10％)。 2. The medical post-art soothing composition suitable for sensitive skin according to claim 1, characterized in that: The mass ratio of the red algae extract, trehalose and Atlantic snapper oil is (0.1-3%): (0.1-2%): (0.1-5%).

3. Use of the medical post-art soothing composition suitable for sensitive skin according to any one of claims 1 to 2 in the preparation of cosmetics with damaged skin repair efficacy.

4. The use according to claim 3, characterized in that: Medical cosmetic surgeries include at least one of photorejuvenation, fractional laser, and laser hair removal.

5. A cosmetic, characterized in that: The cosmetic comprises the medical post-aesthetic soothing composition suitable for sensitive skin according to any one of claims 1 to 2.

6. The cosmetic according to claim 5, characterized in that: The cosmetics are essence, cream, lotion, freeze-dried powder or skin care water.

7. The cosmetic according to claim 5, characterized in that: The cosmetic is an essence, and the essence comprises a soothing composition, a raw material combination A, a raw material combination B, a raw material combination C and a raw material combination D; Based on 100 parts by weight of the essence, the essence comprises 0.3 to 15 parts of a soothing composition, 1.2 to 75 parts of a raw material combination A, 1.2 to 75 parts of a raw material combination B, 0.1 to 5 parts of a raw material combination C, and 0.11 to 6 parts of a raw material combination D; The soothing composition comprises 0.1 to 5 parts of red algae extract, 0.1 to 3 parts of trehalose, and 0.1 to 10 parts of Atlantic seabream oil; the raw material combination A comprises 0.1 to 25 parts of thickener A, 0.1 to 30 parts of skin conditioner A, and 1 to 30 parts of moisturizer A; the raw material combination B comprises 0.1 to 25 parts of thickener B, 0.1 to 30 parts of emulsifier, and 1 to 25 parts of skin conditioner B; the raw material combination C comprises 0.1 to 5 parts of pH regulator; the raw material combination D comprises 0.1 to 5 parts of fragrance and 0.01 to 1 part of preservative.

8. The cosmetic according to claim 7, characterized in that: The raw material combination A also includes water, and the volume of the water is such that the weight parts of the essence reach 100 parts; The thickener A and the thickener B each independently include at least one of acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, polyacrylamide, xanthan gum, propylene glycol, behenyl alcohol, carbomer, laureth-7, cetyl alcohol, stearyl alcohol and hydroxyethyl cellulose.

9. The cosmetic according to claim 7, characterized in that: The skin conditioning agent A and the skin conditioning agent B each independently include at least one of glycerin, isohexadecane, olive oil, sodium hyaluronate, lauryl alcohol, avocado butter, allantoin, butylene glycol, squalane, panthenol, lactic acid, tocopherol and dipotassium glycyrrhizinate; The moisturizing agent A comprises at least one of hyaluronic acid, allantoin, glycerin, ceramide, sodium lactate, butylene glycol, hydrogenated grape seed oil, olive oil and shea butter.

10. The cosmetic according to claim 7, characterized in that: The emulsifier includes at least one of glyceryl stearate citrate, cetearyl glucoside (and) cetearyl alcohol, behenyl trimethyl ammonium methyl sulfate, cocoglycerides and sorbitan olivate; The pH adjuster includes at least one of arginine and lactic acid; The aromatic agent includes essence; The preservative includes at least one of phenoxyethanol, ethylhexylglycerin and pentylene glycol.

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