Anti-dandruff composition based on double barrier repair as well as preparation method and application of anti-dandruff composition

Abstract

The invention provides an anti-dandruff composition based on double barrier repair as well as a preparation method and application thereof, and relates to the technical field of shampoo supplies, the anti-dandruff composition comprises the following effective components: at least two of isodon amethystoides extract, polygonum capitatum extract and myrobalan extract. The compound has a synergistic antibacterial effect, still has a synergistic antibacterial effect after being compounded with OCT, and can be used for replacing or cooperating with OCT, so that the dosage of OCT is reduced, and the irritation is reduced; the anti-dandruff composition has the advantages that the anti-dandruff effect is good, the DPPH free radical scavenging capacity of the anti-dandruff composition is better than that of OCT, the isodon amethystoides extract, the polygonum capitatum extract and the fructus chebulae extract are plant extracts and have no irritation to scalp, the whole anti-dandruff composition has no irritation to the scalp, and the technical problems that in the prior art, anti-dandruff products have certain influences on skin barriers, and the long-acting anti-dandruff effect cannot be achieved are solved.

Description

Technical Field

[0001] The invention relates to the technical field of shampoo products, in particular to an anti-dandruff composition based on double barrier repair and a preparation method and application thereof. Background Art

[0002] The occurrence of dandruff is closely related to the disorder of the scalp barrier function. According to the main functions of the scalp barrier, it can be divided into permeability barrier, antimicrobial barrier, antioxidant barrier, immune response barrier and light protection barrier. When these functional barriers are abnormal, they will interfere with the normal physiological state of the scalp. If they are not repaired in time, they may cause scalp problems or diseases. In particular, the antimicrobial barrier and the antioxidant barrier play a key role in resisting the invasion of pathogens and reducing scalp cell damage (slowing down scalp aging). Therefore, these two barriers are particularly critical in the prevention and treatment of dandruff.

[0003] Antimicrobial barrier: The colonization and proliferation of Malassezia are the key causes of dandruff. Most Malassezia rely on sebum for growth. When the scalp secretes too much sebum, Malassezia secretes lipase to break down triglycerides and saturated fatty acids in the sebum into unsaturated fatty acids, destroying the stratum corneum barrier and causing inflammation and itching. In addition, unsaturated fatty acids promote the entry of calcium ions into cells, leading to excessive keratinocyte keratinization and increased itching, accelerating the formation of dandruff.

[0004] Antioxidant barrier: When the antioxidant barrier of the scalp is damaged, the level of oxidative stress rises, leading to cell membrane damage, DNA mutation, loss of protein function, etc., which will affect the normal metabolism and keratinization process of scalp cells. Moreover, oxidative damage will cause aging of the scalp and cells, resulting in slower scalp renewal, reduced scalp elasticity, and significantly reduced scalp resistance to damage and self-repair after damage. In addition, some scholars have found that scalp lipid peroxides are also an important factor in the occurrence of dandruff.

[0005] In recent years, plant-based anti-dandruff products have attracted much attention due to their small side effects and low drug resistance. However, the efficacy of a single plant extract is often limited and it is difficult to meet the complex and changeable scalp needs. For example, the Chinese patent with application number 202410536821.0 discloses a plant anti-dandruff composition, which is composed of the following components: lotus (NELUMBO NUCIFERA) extract, soybean extract, and licorice extract. The plant anti-dandruff composition can quickly remove dandruff, maintain the scalp in a healthy state for a long time, and is mild and low in irritation. However, the plant composition cannot achieve the same antibacterial effect as chemical reagents. For example, the Chinese patent with application number 202410172831.0 discloses a plant-based antibacterial hair care nanoemulsion and its preparation method, the antibacterial components include: bergamot essential oil, cinnamon extract, lemon essential oil or Litsea cubeba essential oil, clove extract; cinnamon extract is cinnamon essential oil or cinnamaldehyde, and clove extract is clove essential oil or eugenol, which can effectively inhibit bacteria and remove dandruff, control water and oil balance, and nourish hair. However, related ingredients such as cinnamaldehyde, Ceylon cinnamon bark oil, cinnamon leaf oil, citral, eugenol, clove (leaf, flower, stem, bud) oil, etc. are all included in the list of flavor and fragrance allergens of the EU Cosmetics Regulation (EC). They are highly irritating and less mild. They may have a certain impact on the skin barrier and cannot achieve a long-term anti-dandruff effect.

[0006] In view of this, the present invention is proposed. Summary of the invention

[0007] One of the purposes of the present invention is to provide an anti-dandruff composition based on double barrier repair, so as to solve the technical problem that the anti-dandruff products in the prior art have a certain impact on the skin barrier and cannot achieve a long-lasting anti-dandruff effect.

[0008] The second object of the present invention is to provide a method for preparing an anti-dandruff composition based on double barrier repair.

[0009] The third object of the present invention is to provide the use of the above-mentioned anti-dandruff composition or the anti-dandruff composition prepared by the above-mentioned preparation method in the preparation of a product for repairing a damaged scalp barrier.

[0010] A fourth object of the present invention is to provide a product for repairing a damaged scalp barrier.

[0011] In order to achieve the above-mentioned purpose of the present invention, the following technical solutions are particularly adopted:

[0012] In a first aspect, the present invention provides an anti-dandruff composition based on double barrier repair, wherein the effective ingredients of the anti-dandruff composition include at least two of the following: an extract of Ipomoea aquatica, an extract of Polygonum capitatum, and an extract of Terminalia chebula.

[0013] Furthermore, when the active ingredients are two kinds of extracts of Herba Lysimachiae and Polygonum capitatum, the weight ratio of Herba Lysimachiae to Polygonum capitatum is 1 to 8:1;

[0014] Preferably, when the active ingredients are three kinds of extracts of Herba Cibotii, Polygonum capitatum extract and Terminalia chebula extract, the weight ratio of the extracts of Herba Cibotii, Polygonum capitatum extract and Terminalia chebula extract is 1:1:1-8.

[0015] Furthermore, the active ingredient also includes tropolone;

[0016] Preferably, when any one of the active ingredients of the Herba Cibotii extract, the Herba Polygonum capitatum extract or the Herba Terminaliae extract is combined with tropolone, the weight ratio of any one of the Herba Cibotii extract, the Herba Polygonum capitatum extract or the Herba Terminaliae extract to tropolone is 1 to 16:1;

[0017] Preferably, when two active ingredients in the extract of Herba Cibotii, Polygonum capitatum extract or Terminalia chebula extract are combined with tropolone, the weight ratio of the two active ingredients in the extract of Herba Cibotii, Polygonum capitatum extract or Terminalia chebula extract to tropolone is 1-4:1-4:1-2;

[0018] Preferably, when the Herba Cibotii extract, the Herba Polygoni capitata extract, the Herba Terminaliae extract and the Herba Cibotii are combined, the weight ratio of the Herba Cibotii extract, the Herba Polygoni capitata extract, the Herba Terminaliae extract and the Herba Cibotii is 1-8:1-8:1-32:1-10.

[0019] Furthermore, the active ingredient further comprises OCT, and the OCT is combined with at least two active ingredients selected from the group consisting of an extract of Herba Cibotii, an extract of Polygonum capitatum, an extract of Terminalia chebula, or tropolone;

[0020] Preferably, the weight ratio of the sum of at least two active ingredients in the extract of Ipomoea batatas, the extract of Polygonum capitatum, the extract of Terminalia chebula or the extract of Tropolone to OCT is 1:1.

[0021] Further, when two active ingredients of the Herba Cibotii extract, the Herba Polygoni Capitis extract, the Herba Terminaliae extract or the Herba Cibotii are combined with OCT, the weight ratio of the two active ingredients of the Herba Cibotii extract, the Herba Polygoni Capitis extract, the Herba Terminaliae extract or the Herba Cibotii extract to OCT is 1:1:2;

[0022] Preferably, when the Herba Cibotii extract, the Herba Polygoni Capitis extract, the Herba Terminaliae extract and OCT are combined, the weight ratio of the Herba Cibotii extract, the Herba Polygoni Capitis extract, the Herba Terminaliae extract and OCT is 1:1:1-4:3-6;

[0023] Preferably, when two active ingredients in the extract of Herba Cibotii, Polygonum capitatum extract or Terminalia chebula extract are combined with tropolone and OCT, the weight ratio of the two active ingredients in the extract of Herba Cibotii, Polygonum capitatum extract or Terminalia chebula extract to tropolone and OCT is 1:1:1-2:3-4;

[0024] Preferably, when the Herba Cibotii extract, the Herba Polygoni Capitis extract, the Herba Terminaliae extract, the Herba Cibotii extract and the OCT are combined, the weight ratio of the Herba Cibotii extract, the Herba Polygoni Capitis extract, the Herba Terminaliae extract, the Herba Cibotii extract and the OCT is 1:1:1-4:1-6:4-12;

[0025] Preferably, the extract of Ampelopsis pilosula includes at least one of an extract of the whole plant of Ampelopsis pilosula, an extract of the leaves of Ampelopsis pilosula, or an extract of the stem of Ampelopsis pilosula;

[0026] Preferably, the terminalia chebula extract comprises at least one of a terminalia chebula whole plant extract, a terminalia chebula fruit extract, a terminalia chebula root extract or a terminalia chebula bark extract.

[0027] In a second aspect, the present invention provides a method for preparing the above anti-dandruff composition, which is prepared by measuring solutions of various components according to the formula and mixing them.

[0028] Furthermore, the preparation methods of the extract of Herba Cibotii, Polygonum capitatum and Terminalia chebula include taking the raw materials, adding 4 to 12 times the mass of the extracting solution, soaking and ultrasonic extraction, and concentrating the filtrate;

[0029] Preferably, the extract comprises 30% to 70% alcohol solution or water;

[0030] Preferably, the alcohol solution comprises an ethanol solution or a butanediol solution;

[0031] Preferably, the soaking time is 30 to 90 minutes, preferably 60 minutes;

[0032] Preferably, the ultrasonic time is 20 to 60 minutes, preferably 20 minutes;

[0033] Preferably, the number of immersion and ultrasonic extraction is 1 to 2 times, and the filtrates are combined and concentrated.

[0034] In a third aspect, the present invention provides use of the anti-dandruff composition or the anti-dandruff composition prepared by the above preparation method in preparing a product for repairing a damaged scalp barrier.

[0035] Further, the barrier comprises an antimicrobial barrier and / or an antioxidant barrier.

[0036] Furthermore, the product includes a shampoo or a hair care product.

[0037] In a fourth aspect, the present invention provides a product for repairing a damaged scalp barrier, comprising the anti-dandruff composition described above or the anti-dandruff composition prepared by the above preparation method.

[0038] The present invention provides an anti-dandruff composition based on double barrier repair. Compared with the use of each component alone, the combination of at least two of the extract of Herba Cibotii, Polygonum capitatum extract and Terminalia chebula extract in a certain proportion has a synergistic antibacterial effect, which is better than the antibacterial effect of single use, and still has a synergistic antibacterial effect after compounding with OCT, and can replace or cooperate with OCT to reduce the dosage of OCT and reduce irritation; the scavenging ability of DPPH free radicals is better than OCT. The extract of Herba Cibotii, Polygonum capitatum extract and Terminalia chebula extract are plant extracts, which are non-irritating to the scalp. The composition as a whole is non-irritating to the scalp, which solves the technical problem that the anti-dandruff products in the prior art have a certain impact on the skin barrier and cannot achieve a long-term anti-dandruff effect. DETAILED DESCRIPTION

[0039] Unless otherwise defined herein, scientific and technical terms used in conjunction with the present invention shall have the meanings commonly understood by those of ordinary skill in the art. The meaning and scope of the terms should be clear, however, in the case of any potential ambiguity, the definitions provided herein take precedence over any dictionary or external definitions. In this application, unless otherwise stated, the use of "or" means "and / or". In addition, the use of the term "including" and other forms is non-limiting.

[0040] The methods and techniques of the present invention are generally performed according to conventional methods well known in the art and as described in various general and more specific references that are cited and discussed throughout the present specification unless otherwise indicated.

[0041] In one aspect, the present invention provides an anti-dandruff composition based on double barrier repair, wherein the effective ingredients of the anti-dandruff composition include at least two of an extract of Ipomoea aquatica, an extract of Polygonum capitatum and an extract of Terminalia chebula.

[0042] Compared with the use of each component alone, the composition uses at least two of the extracts of Herba Cibotii, Polygonum capitatum and Terminalia chebula to have a synergistic antibacterial effect, which is better than the effect of each component alone. After compounding with OCT, it still has a synergistic antibacterial effect, and can replace or cooperate with OCT to reduce the amount of OCT used and reduce irritation. The scavenging ability of DPPH free radicals is better than OCT. The extracts of Herba Cibotii, Polygonum capitatum and Terminalia chebula are plant extracts that are non-irritating to the scalp. The composition as a whole is non-irritating to the scalp, which solves the technical problem that anti-dandruff products in the prior art have a certain impact on the skin barrier and cannot achieve a long-term anti-dandruff effect.

[0043] In some specific embodiments, when the active ingredients are two kinds of extracts from Herba Lysimachiae and Polygonum capitatum, the weight ratio of the extracts from Herba Lysimachiae to Polygonum capitatum is 1 to 8:1.

[0044] The weight ratio of the Herba Polygoni Capitis extract to the Herba Polygoni Capitis extract may be, but is not limited to, 1:1, 2:1, 3:1, 4:1, 5:1, 6:1, 7:1 or 8:1, or any ratio between 1 and 8:1.

[0045] In some specific embodiments, when the active ingredients are three kinds of extracts of Herba Cibotii, Polygonum capitatum extract and Terminalia chebula extract, the weight ratio of Herba Cibotii extract, Polygonum capitatum extract and Terminalia chebula extract is 1:1:1-8.

[0046] The weight ratio of the Herba Cibotii extract, the Herba Polygonum capitatum extract and the Herba Terminaliae chebulae extract may be, but is not limited to, 1:1:1, 1:1:2, 1:1:4, 1:1:6 or 1:1:8, or any ratio between 1:1:1 and 8.

[0047] In some specific embodiments, the active ingredient further comprises tropolone.

[0048] Tropolone is a natural active ingredient and is not an allergen. It is non-irritating to the scalp when used in combination with plant extracts. Tropolone is added to plant extracts, and each component has a synergistic antibacterial effect, which is better than the antibacterial effect of OCT; the combination has a better ability to scavenge DPPH free radicals than OCT; it has both antibacterial and antioxidant effects, can repair antimicrobial barriers and antioxidant barriers, and completely replace the use of OCT.

[0049] In some specific embodiments, when any active ingredient of the Herba Cibotii extract, the Herba Polygonum capitatum extract or the Herba Terminaliae extract is combined with tropolone, the weight ratio of any active ingredient of the Herba Cibotii extract, the Herba Polygonum capitatum extract or the Herba Terminaliae extract to tropolone is 1 to 16:1.

[0050] Among them, the weight ratio of any active ingredient in the Herba Lycopodiellae extract, the Polygonum capitatum extract or the Terminalia chebula extract to tropolone can be but is not limited to 1:1, 2:1, 3:1, 4:1, 5:1, 6:1, 8:1, 10:1, 13:1, 15:1 or 16:1, or it can be any ratio between 1 and 16:1.

[0051] In some specific embodiments, when two active ingredients in the Herba Cibotii extract, the Herba Polygonum capitatum extract or the Herba Terminaliae extract are combined with tropolone, the weight ratio of the two active ingredients in the Herba Cibotii extract, the Herba Polygonum capitatum extract or the Herba Terminaliae extract to tropolone is 1-4:1-4:1-2.

[0052] Among them, the weight ratio of the two active ingredients in the Herba Cibotii extract, the Polygonum capitatum extract or the Terminalia chebula extract to tropolone can be but not limited to 1:1:1, 1:1:2, 2:2:1, 3:3:1, 3:3:2 or 4:4:1, and can also be any ratio between 1 and 4:1 and 4:1 and 2.

[0053] In some specific embodiments, when the Herba Cibotii extract, the Herba Polygonum capitatum extract, the Herba Terminaliae extract and the Herba Cibotii are combined, the weight ratio of the Herba Cibotii extract, the Herba Polygonum capitatum extract, the Herba Terminaliae extract and the Herba Cibotii is 1-8:1-8:1-32:1-10.

[0054] The weight ratio of the extract of Herba Cibotii, the extract of Polygonum capitatum, the extract of Terminalia chebula and tropolone can be, but is not limited to, 1:1:1:1, 1:1:1:2, 1:1:1:3, 1:1:1:4, 1:1:4:1, 1:1:4:3, 1:1:4:6, 1:1:6:1, 1:1:6:2, 1:1:6:4, 1:1:6:8, 1:1:8:5, 1:1:8:10, 2:2:2:1, 2:2:2:3, 2:2:4:1, 2:2:16:5, 3:3:3:4, 3:3:6:2, 3:3:18:4, 3:3:24:5, 4:4:4:3, 4:4:16:3, 4:4:32:5, 5:5:5:3, 6:6:6:5, 7:7:7:3, 8:8:8:3 or 8:8:32:10, or any ratio between 1-8:1-8:1-32:1-10.

[0055] In some specific embodiments, the active ingredient further comprises OCT, and the OCT is combined with at least two active ingredients selected from the group consisting of Ipomoea aquatica extract, Polygonum capitatum extract, Terminalia chebula extract, and Tropolone.

[0056] In some specific embodiments, the weight ratio of the sum of at least two active ingredients of the extract of Ipomoea batatas, the extract of Polygonum capitatum, the extract of Terminalia chebula or the extract of Tropolone to OCT is 1:1.

[0057] In some specific embodiments, when two active ingredients of Herba Cibotii extract, Polygonum capitatum extract, Terminalia chebula extract or tropolone are combined with OCT, the weight ratio of the two active ingredients of Herba Cibotii extract, Polygonum capitatum extract, Terminalia chebula extract or tropolone to OCT is 1:1:2.

[0058] In some specific embodiments, when the Herba Cibotii extract, the Herba Polygonum capitatum extract, the Herba Terminaliae extract and OCT are combined, the weight ratio of the Herba Cibotii extract, the Herba Polygonum capitatum extract, the Herba Terminaliae extract and OCT is 1:1:1-4:3-6.

[0059] Among them, the weight ratio of the Herba Cibotii extract, the Polygonum capitatum extract, the Terminalia chebula extract and OCT can be but not limited to 1:1:1:3, 1:1:1.5:3.5, 1:1:2:4, 1:1:2.5:4.5, 1:1:3:5, 1:1:3.5:5.5 or 1:1:4:6, and can also be any ratio between 1:1:1 and 4:3 and 6.

[0060] In some specific embodiments, when two active ingredients in the Herba Cibotii extract, the Herba Polygonum capitatum extract or the Herba Terminaliae extract are combined with tropone and OCT, the weight ratio of the two active ingredients in the Herba Cibotii extract, the Herba Polygonum capitatum extract or the Herba Terminaliae extract to tropone and OCT is 1:1:1 to 2:3 to 4.

[0061] Among them, the weight ratio of the two active ingredients in the Herba Lycopodiellae extract, the Polygonum capitatum extract or the Terminalia chebula extract to tropolone and OCT can be but not limited to 1:1:1:3, 1:1:1.1:3.1, 1:1:1.2:3.2, 1:1:1.3:3.3, 1:1:1.4:3.4, 1:1:1.5:3.5, 1:1:1.6:3.6, 1:1:1.7:3.7, 1:1:1.8:3.8, 1:1:1.9:3.9 or 1:1:2:4, and can also be any ratio between 1:1:1 and 2:3 and 4.

[0062] In some specific embodiments, when the Herba Cibotii extract, the Herba Polygonum capitatum extract, the Herba Terminaliae extract, the Herba Cibotii extract and OCT are combined, the weight ratio of the Herba Cibotii extract, the Herba Polygonum capitatum extract, the Herba Terminaliae extract, the Herba Cibotii extract and OCT is 1:1:1-4:1-6:4-12.

[0063] Among them, the weight ratio of the Herba Lysimachiae extract, the Polygonum capitatum extract, the Terminalia chebula extract, the tropolone and OCT can be but not limited to 1:1:1:1:4, 1:1:1.5:1.5:5, 1:1:2:2:6, 1:1:2:2.5:6.5, 1:1:2:3:7, 1:1:2.5:3:7.5, 1:1:3:3:8, 1:1:3.5:3:8.5, 1:1:4:3:9, 1:1:4:4:10, 1:1:4:5:11 or 1:1:4:6:12, and can also be any ratio between 1:1:1~4:1~6:4~12.

[0064] In some specific embodiments, preferably, the extract of Ampelopsis ternata includes at least one of an extract of the whole plant of Ampelopsis ternata, an extract of leaves of Ampelopsis ternata or an extract of Ampelopsis ternata stem.

[0065] In some specific embodiments, the terminalia chebula extract includes at least one of a terminalia chebula whole plant extract, a terminalia chebula fruit extract, a terminalia chebula root extract or a terminalia chebula bark extract.

[0066] According to another aspect of the present invention, a method for preparing the anti-dandruff composition is also provided, which is prepared by measuring solutions of various components according to the formula and mixing them.

[0067] In some specific embodiments, the preparation methods of the Herba Ichthyophthirii extract, the Herba Polygonum Capitis extract and the Herba Terminaliae Chebulae extract include adding 4 to 12 times the mass of the raw materials to the extracting solution, immersing and performing ultrasonic extraction, and concentrating the filtrate.

[0068] In some specific embodiments, the extract comprises 30% to 70% alcohol solution or water.

[0069] In some specific embodiments, the alcohol solution comprises an ethanol solution or a butanediol solution.

[0070] In some specific embodiments, the soaking time is 30 to 90 minutes.

[0071] In some specific embodiments, the ultrasound duration is 20 to 60 minutes.

[0072] The soaking time may be, but is not limited to, 30 min, 35 min, 40 min, 45 min, 50 min, 55 min, 60 min, 65 min, 80 min or 90 min, and may be any value between 20 and 60 min, preferably 60 min.

[0073] The ultrasonic time may be, but is not limited to, 20 min, 25 min, 30 min, 35 min, 40 min, 45 min, 50 min, 55 min or 60 min, and may be any value between 20 and 60 min, preferably 20 min.

[0074] In some specific embodiments, the number of immersion ultrasonic extraction is 1 to 2 times, and the filtrates are combined and concentrated.

[0075] According to another aspect of the present invention, there is also provided the use of the anti-dandruff composition or the anti-dandruff composition prepared by the above preparation method in preparing a product for repairing a damaged scalp barrier.

[0076] In some specific embodiments, the barrier comprises an antimicrobial barrier and / or an antioxidant barrier.

[0077] In some specific embodiments, the product comprises a hair shampoo or a hair care product.

[0078] According to another aspect of the present invention, there is also provided a product for repairing a damaged scalp barrier, comprising the anti-dandruff composition described above or the anti-dandruff composition prepared by the above preparation method.

[0079] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0080] 1. Composition for improving recurrent dandruff

[0081] The specific components of an anti-dandruff composition based on double barrier repair provided by each embodiment and comparative example are shown in Table 1 and Table 2.

[0082] Table 1 Compositions of different proportions of Herba Cibotii, Polygonum capitatum, Myrobalan, and Tropolone

[0083]

[0084]

[0085] Table 2 Compositions of different proportions of Herba Cibotii, Polygonum capitatum, Myrobalan, Tropolone, and OCT

[0086]

[0087]

[0088] According to the formula amounts shown in Table 1 and Table 2, the anti-dandruff composition of each embodiment was prepared according to the following steps:

[0089] (1) Plant extracts - preparation of Ipomoea batatas extract, Polygonum capitatum extract and Terminalia chebula extract:

[0090] Weigh 15g of the plant, add 10 times the amount of 70% ethanol and soak for 60min, ultrasonically extract twice, 20min each time. Combine the two filtrates and concentrate to 1g / mL, centrifuge to obtain the supernatant, dilute with sterile enzyme-free water to a concentration of 200mg / mL, and store at 4℃ for later use.

[0091] The extract of Herba Cibotii is the extract of Herba Cibotii leaves / stalks. The extract of Herba Chebulii is the extract of Herba Chebulii fruit.

[0092] (2) Preparation of the compositions of Examples 1 to 10 (excluding tropolone and OCT):

[0093] The plant extract prepared in step (1) was used to prepare a composition, the total concentration of the composition was 200 mg / mL, the total concentration was not changed, and the proportions of the components were adjusted according to the formula amounts shown in Table 1.

[0094] (3) Examples 11 to 60 Preparation of compositions containing plant extracts, tropolone and / or OCT:

[0095] ① The plant extract prepared in step (1) was diluted with sterile enzyme-free water to obtain a stock solution with a concentration of 50 mg / mL.

[0096] ② Preparation of tropolone stock solution and OCT stock solution: Tropolone and OCT were dissolved in ethanol (0.2% Tween for solubilization) to prepare a stock solution with a concentration of 50 mg / mL; the tube of the stock solution was sealed with a sealing film and stored in a 4°C refrigerator away from light for future use.

[0097] ③ The total concentration of the composition containing plant extract, tropolone and / or OCT is 50 mg / mL. The total concentration is not changed, and the proportions of the components are adjusted according to the formula amounts shown in Tables 1 and 2.

[0098] 2. Testing the inhibitory effect of Malassezia

[0099] This test evaluates the inhibitory effect of each anti-dandruff composition on Malassezia by determining the minimum inhibitory concentration (MIC) of the anti-dandruff composition by the microbroth dilution method; and evaluates the synergistic antibacterial effect of each component of the anti-dandruff composition by exploring the synergistic effect index (CI) to find an excellent antimicrobial barrier composition.

[0100] 1. Test Materials

[0101] Malassezia furfur (M. furfur, ATCC44344) was purchased from Shanghai Microorganism Collection Center, piroctone ethanolamine (OCT) was purchased from Tongmeiyuan (Guangdong) Biotechnology Co., Ltd., tropolone was purchased from Hubei Jinyoute Biotechnology Co., Ltd., and Camellia ternata, Polygonum capitata and Terminalia chebula were purchased from Qingping Market.

[0102] 2. Test Method

[0103] (1) Preparation of modified Dxion (mDixon) medium and modified Dxion (mDixon) agar medium: According to the instructions, accurately weigh the medium granules, agar powder and deionized water into a beaker and stir with a glass rod until the granules are completely dissolved. Adjust the pH value to 6.1±0.1, dispense into conical bottles, seal them, and sterilize them by high pressure at 121℃ for 30 min. After cooling, store them in a refrigerator at 4℃ for later use.

[0104] (2) Preparation of bacterial suspension: Take out the glycerol tube of the test bacteria stored in the -20℃ refrigerator, use an inoculation loop to take 20μL of bacterial solution, inoculate it on the agar slant by streaking method, and place it in a 32℃ constant temperature incubator for 2 days. Rinse the slant with physiological saline to obtain a high-concentration bacterial suspension. Take another test tube, pour in an appropriate amount of raw salt, take an appropriate amount of high-concentration bacterial suspension, so that its turbidity is consistent with that of a No. 5 McFarland turbidimetric tube, and obtain a final concentration of 1×10 6 CFU / mL bacterial suspension.

[0105] (3) Determination of MIC value

[0106] ① Culture method: Add 100 μL of modified Dixon (mDixon) liquid medium to the 2nd to 11th columns of the 96-well plate, and add 200 μL of modified Dixon (mDixon) liquid medium to the 12th column. Add 200 μL of each test drug to the 1st column, and take 100 μL to dilute it horizontally to the 10th column (discard the excess 100 μL of drug solution). Then take the bacterial suspension prepared in (2) and add it to the 1st to 11th columns, 100 μL in each well. At this time, the final volume of each well is 200 μL. The 11th column is the growth control well, and the 12th column is the blank control well. Place the 96-well plate at 32°C and incubate for 1 to 2 days.

[0107] ②Evaluation criteria: Observe with the naked eye. The concentration of the drug solution in the sterile growth hole is the minimum inhibitory concentration (MIC).

[0108] (4) Synergistic antibacterial testing and evaluation

[0109] ① The Chou Talalay model is a commonly used pharmacological model used to evaluate the synergistic and antagonistic effects of compound combinations during the onset of action. The MIC of each example was measured according to the method described in (3), and the synergistic effect index (CI) was calculated using the Chou Talalay formula to determine whether the combination was synergistic or not. The formula is as follows:

[0110]

[0111] ②Evaluation criteria: Ca, Cb, Cc, and Cd are the concentrations corresponding to the antibacterial effects of components A, B, C, and D when acting alone; C A , C B , C C , C D It indicates the inhibitory effect observed at the corresponding concentration when each component is compounded into a composition, C A～D Result = Composition MIC experimental data × C ADThe proportion of a component in a composition. If CI < 1, it indicates a synergistic effect; if CI = 1, it indicates no interaction; and if CI > 1, it indicates an antagonistic effect.

[0112] 3. Test results

[0113] (1) The antibacterial test results of OCT and various embodiments are shown in Table 3.

[0114] Table 3

[0115]

[0116]

[0117]

[0118] As shown in Table 3, the MIC of the comparative example OCT is 31.25 μg / mL. The following is a summary of the results of the comparative examples and embodiments:

[0119] (1) Comparative Examples 1 to 4 are for the use of each drug alone. Compared with the comparative example OCT, the MICs of the extracts of Herba Cibotii, Polygonum capitatum, and Terminalia chebula were lower than those of OCT. The MIC of tropolone was 7.8125 μg / mL, which is the MIC OCT The antibacterial effect was significantly better than that of OCT.

[0120] (2) Examples 1 to 10 are compositions of plant extracts.

[0121] ① Examples 1 to 5 are compositions of the extract of Herba Cibotii and the extract of Polygonum capitatum. The antibacterial synergistic coefficients CI of the compositions of Herba Cibotii and Polygonum capitatum extracts in different ratios are all <1, and all have synergistic antibacterial effects, that is, when the ratio of Herba Cibotii extract to Polygonum capitatum extract is 1 to 8:1, the compositions have synergistic antibacterial effects, which are inferior to OCT, but better than the antibacterial effects of Herba Cibotii extract and Polygonum capitatum extract alone.

[0122] ②Examples 6-10 are compositions of Herba Cibotii extract, Polygonum capitatum extract and Terminalia chebula extract. The synergistic coefficients CI of the compositions in different proportions are all <1, and all have synergistic antibacterial effects, that is, when Herba Cibotii extract: Polygonum capitatum extract: Terminalia chebula extract = 1:1:1-8, the plant extract composition has a synergistic antibacterial effect, which is not as good as OCT, but better than the antibacterial effect of Herba Cibotii extract and Polygonum capitatum extract alone; compared with Examples 1-5, the antibacterial effect of the composition containing Terminalia chebula extract is better than the antibacterial effect of the composition without Terminalia chebula extract.

[0123] (3) Examples 11-47 are compositions of different proportions of the extract of Ipomoea batatas, the extract of Polygonum capitatum, the extract of Terminalia chebula, and tropolone (compositions without OCT), and the CIs are all <1, and all have synergistic antibacterial effects.

[0124] ① Examples 11 to 16 are compositions of terminalia chebula extract and tropolone in different ratios, and the CI is all <1, and all have synergistic antibacterial effects, that is, when terminalia chebula extract: tropolone = 1 to 16:1, the composition has a synergistic antibacterial effect, wherein when terminalia chebula extract: tropolone = 1 to 8:1, the MIC 组合物 ≤MIC OCT , can replace OCT, and its antibacterial effect is better than or equivalent to OCT.

[0125] ② Examples 17-21 are compositions of different proportions of Herba Cibotii extract, Polygonum capitatum extract, and Tropolone, and CI is all <1, and all have synergistic antibacterial effects, that is, when Herba Cibotii extract: Polygonum capitatum extract: Tropolone = 1-4:1-4:1-2, the composition has a synergistic antibacterial effect, wherein when Herba Cibotii extract: Polygonum capitatum extract: Tropolone = 1-3:1-3:1-2, MIC 组合物 ≤MIC OCT , can replace OCT, and its antibacterial effect is better than or equivalent to OCT.

[0126] ③ Examples 22-47 are compositions of different proportions of scutellaria baicalensis extract, Polygonum capitatum extract, Terminalia chebula extract, and tropolone, and CI is all <1, and all have synergistic antibacterial effects. That is, when scutellaria baicalensis extract: Polygonum capitatum extract: Terminalia chebula extract: tropolone = 1-8:1-8:1-32:1-10, the composition has a synergistic antibacterial effect, and the MIC 组合物 ≤MIC OCT , can replace OCT, and its antibacterial effect is better than or equivalent to OCT.

[0127] (4) Examples 48-60 are compositions of different proportions of Herba Cibotii extract, Polygonum capitatum extract, Terminalia chebula extract, tropolone, and OCT (compositions containing OCT), and CI is all <1, and all have synergistic antibacterial effects. The combined use of Herba Cibotii extract, Polygonum capitatum extract, Terminalia chebula extract, tropolone and OCT can reduce the dosage of OCT and achieve an antibacterial result equivalent to or better than that of OCT.

[0128] 3. Determination of DPPH free radical scavenging ability

[0129] This test evaluates the ability of the anti-dandruff composition of the above-mentioned embodiments and comparative examples to resist oxidative damage by measuring the scavenging ability of DPPH free radicals.

[0130] 1. Test materials: 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH) was purchased from Shanghai MacLean Biochemical Technology Co., Ltd.

[0131] 2. Test Method

[0132] Prepare the sample concentrations of 2mg / ml and 500μg / mL, take 500μL of sample solutions of different concentrations into plastic centrifuge tubes with a pipette, add 500μL DPPH (0.2mmol / L, prepared in ethanol) solution, shake well and keep away from light for 30 minutes, use ethanol as blank control, measure its absorbance at 517nm, and perform 3 parallel experiments. The specific calculation formula is as follows:

[0133]

[0134] Note: D1 is the absorbance of the test sample or positive control; D2 is the absorbance of the blank control.

[0135] 3. Test results

[0136] (1) The antioxidant test results of different anti-dandruff compositions are shown in Table 4.

[0137] Table 4

[0138]

[0139]

[0140]

[0141] As shown in Table 4, the clearance rate of the comparative example OCT concentration of 2 mg / mL reached 60.28%, and the clearance rate of the concentration of 500 μg / mL reached 29.37%; the clearance rate of the comparative example VC concentration of 2 mg / mL reached 89.99%, and the clearance rate of the concentration of 500 μg / mL reached 89.35%. The following is a summary of the results of the comparative examples and embodiments:

[0142] (1) Comparative Examples 1 to 4 are for the use of each drug alone.

[0143] At a concentration of 2 mg / mL: the clearance rates of Polygonum capitatum extract and Terminalia chebula extract were similar to that of VC, much better than that of OCT, about 1.49 times that of OCT, 29.46% and 29.55% higher than that of OCT, respectively; the clearance rates of Ipomoea aquatica extract and tropolone were lower than those of OCT and VC.

[0144] At a concentration of 500 μg / mL: the clearance rates of Polygonum capitatum extract and Terminalia chebula extract were much better than that of OCT, which were 1.64 times (18.89%) and 2.96 times (57.47%) higher than that of OCT, respectively. The clearance rate of Terminalia chebula extract was similar to that of VC, both > 80%. The clearance rates of Ipomoea batatas extract and tropolone were lower than those of OCT and VC.

[0145] Combined with the antibacterial results, it can be seen that the antibacterial effects of Polygonum capitatum extract and Terminalia chebula extract are not as good as OCT, but the antioxidant effect is significantly better than OCT, and they have the potential to be an ideal antioxidant substitute for OCT; the antibacterial effect of tropolone is much better than OCT, but the antioxidant effect is not as good as OCT, and it has the potential to be an antibacterial substitute for OCT; the antibacterial and antioxidant effects of Camellia oleifera extract are not as good as OCT.

[0146] (2) Examples 1 to 10 are compositions of plant extracts.

[0147] ① Examples 1 to 5 are compositions of the extract of Ipomoea aquatica and the extract of Polygonum capitatum.

[0148] At a concentration of 2 mg / mL: the scavenging effects of different proportions of the combination of Ampelopsis pilosula extract and Polygonum capitatum extract on DPPH free radicals are better than OCT (12.40%-29.08%), and the scavenging rate of the combination gradually decreases with the increase of the proportion of Ampelopsis pilosula extract, but its scavenging effect is much better than that of Ampelopsis pilosula extract alone (the scavenging rate of the combination is 17.25%-33.93% higher than that of Ampelopsis pilosula extract alone, that is, Polygonum capitatum extract can enhance the antioxidant effect of Ampelopsis pilosula extract); in Examples 1 to 3, i.e., when the ratio of Ampelopsis pilosula extract: Polygonum capitatum extract = 1 to 4:1, the scavenging rate of the combination is >80%.

[0149] At a concentration of 500 μg / mL: the scavenging effect of different proportions of the combination of the extract of Ampelopsis pilosula and the extract of Polygonum capitatum on DPPH free radicals was similar to that of OCT, but not as good as that of OCT, but much better than the scavenging effect of the extract of Ampelopsis pilosula alone.

[0150] Combined with the antibacterial results, it can be seen that the antioxidant effect of the combination of different proportions of Camellia oleracea extract and Polygonum capitatum extract at a concentration of 2 mg / mL is better than that of OCT, and can replace the antioxidant effect of OCT; Polygonum capitatum extract can enhance the antioxidant effect of Camellia oleracea extract, and the combination of the two is better than the antioxidant effect of Camellia oleracea extract alone at two concentrations; the antibacterial synergistic coefficient CI of the combinations of different proportions of Camellia oleracea extract and Polygonum capitatum extract are all <1, and both have synergistic antibacterial effects, which are better than the antibacterial effects of Camellia oleracea extract and Polygonum capitatum extract alone; when Camellia oleracea extract and Polygonum capitatum extract are used in combination, Camellia oleracea extract can enhance the antibacterial effect of Polygonum capitatum extract, and Polygonum capitatum extract can enhance the antioxidant effect of Camellia oleracea extract.

[0151] ② Examples 6 to 10 are compositions of the extract of Ipomoea batatas, the extract of Polygonum capitatum and the extract of Terminalia chebula.

[0152] At the two concentrations of 2 mg / mL and 500 μg / mL, Examples 6 to 10 (i.e., Camellia ternata extract: Polygonum capitatum extract: Terminalia chebula extract = 1:1:1-8) have much better scavenging effects on DPPH free radicals than OCT, and are >80%, and can be used as an ideal antioxidant substitute for OCT.

[0153] Combined with the antibacterial results, it can be seen that the antibacterial and antioxidant effects of the combination of Herba Cibotii extract, Herba Polygonum capitatum extract and Herba Terminaliae extract, i.e., Herba Cibotii extract: Herba Polygonum capitatum extract: Herba Terminaliae extract = 1:1:1-8, are significantly improved, which is better than the effects of Herba Cibotii extract and Herba Polygonum capitatum extract alone; the improvement of the antibacterial and antioxidant effects of Herba Terminaliae extract is more significant; Examples 6 to 10 can be used as ideal substitutes for OCT antioxidant.

[0154] (3) Examples 11-47 are compositions of different proportions of the extract of Ipomoea batatas, the extract of Polygonum capitatum, the extract of Terminalia chebula, and tropolone (compositions without OCT).

[0155] ① Examples 11-16 are compositions of terminalia chebula extract and tropolone in different proportions.

[0156] At the two concentrations of 2 mg / mL and 500 μg / mL, Examples 11-16, i.e., when the ratio of Terminalia chebula extract to tropolone is 1 to 16:1, have significantly better antioxidant effects than OCT and can be used as an ideal substitute for OCT antioxidant activity. The clearance rates are all >88%. As the proportion of Terminalia chebula extract increases, the antioxidant capacity of the composition also gradually increases.

[0157] Combined with the antibacterial results, it can be seen that when the ratio of Terminalia chebula extract to tropolone is 1 to 8:1, the composition can be used as an ideal substitute for OCT for both antibacterial and antioxidant effects.

[0158] ②Examples 17-21 are compositions of different proportions of the extract of Ipomoea aquatica, the extract of Polygonum capitatum and tropone.

[0159] At a concentration of 2 mg / mL, the antioxidant effect of Examples 21-25 is about 1.46 times that of OCT (27.52%-27.84% greater), which is significantly better than OCT; that is, when the ratio of Ipomoea batatas extract: Polygonum capitatum extract: tropone = 1-4:1-4:1-2, the composition can be used as an ideal antioxidant substitute for OCT.

[0160] At a concentration of 500 μg / mL, the antioxidant effect of the combination was inferior to that of OCT, but significantly superior to the antioxidant effects of the extract of Ipomoea batatas and tropolone alone.

[0161] Combined with the antibacterial results, it can be seen that when the ratio of schizonepeta extract: Polygonum capitatum extract: tropolone = 1-3:1-3:1-2, it can be used as an antibacterial substitute for OCT (MIC 组合物 ≤MIC OCT ) and antioxidant alternatives at a concentration of 2 mg / mL.

[0162] ③ Examples 22 to 47 are compositions of different proportions of the extract of Ipomoea batatas, the extract of Polygonum capitatum, the extract of Terminalia chebula, and tropolone.

[0163] At the two concentrations of 2 mg / mL and 500 μg / mL, Examples 22 to 47, i.e., Camellia oleifera extract: Polygonum capitatum extract: Terminalia chebula extract: Tropolone = 1-8:1-8:1-32:1-10, have significantly better antioxidant effects than OCT and can be used as an ideal substitute for OCT antioxidant activity. The clearance rates are all >87%. As the specific gravity of Terminalia chebula extract increases, the antioxidant capacity of the composition also gradually increases.

[0164] Combined with the antibacterial results, it can be seen that when the ratio of the extract of Herba Cibotii: the extract of Polygonum capitatum: the extract of Terminalia chebula: the extract of Cyperus rotundus: the tropolone = 1-8:1-8:1-32:1-10, the composition can be used as an ideal substitute for OCT for both antibacterial and antioxidant effects. Combined with the results of ① in (3), it can be seen that Terminalia chebula has a significant improvement in both antibacterial and antioxidant effects, and is a better compound ingredient.

[0165] (4) Examples 48-60 are compositions of different proportions of the extract of Ipomoea batatas, the extract of Polygonum capitatum, the extract of Terminalia chebula, tropolone, and OCT (compositions containing OCT).

[0166] At the two concentrations of 2 mg / mL and 500 μg / mL, except for Examples 48 to 50 at 500 μg / mL, the scavenging effects of the other compositions on DPPH free radicals were better than those of OCT, and a better antioxidant effect could be achieved by reducing the amount of OCT.

[0167] Combined with the antibacterial results, it can be seen that the combination of OCT with Ipomoea batatas extract, Polygonum capitatum extract, Terminalia chebula extract, tropolone and OCT to form a composition can reduce the dosage of OCT and achieve antibacterial and antioxidant results equivalent to or better than those of OCT.

[0168] 4. Application of shampoo suitable for dual barrier repair composition

[0169] This application provides two anti-dandruff shampoo formulas suitable for "double barrier repair composition". The anti-dandruff compositions of Examples 13, 15, 30, 36, and 47 are respectively selected to prepare anti-dandruff volumizing shampoo and anti-dandruff amino acid shampoo, and OCT is used instead of the anti-dandruff composition as a comparative example.

[0170] Application Example 1: The weight parts of the components of the anti-dandruff and volumizing shampoo are shown in Table 5, and the preparation method thereof comprises the following steps:

[0171] S1. Add the A1 phase water into the main pot, add the remaining A1 phase materials under homogenization, disperse completely, add the A2 phase materials, stir well, heat to 80-85°C, add the A3 phase materials and stir to dissolve completely;

[0172] S2. Add phase B, stir thoroughly until completely dissolved, and start stirring to cool down;

[0173] S3. Cool down to 45-50°C, add the raw materials of phase C in sequence, and stir evenly until transparent;

[0174] S4. Add the D phase materials in sequence, stir and cool to room temperature;

[0175] S5. Take samples for testing, and discharge the materials after they pass the testing.

[0176] Application Example 2: The weight parts of the components of the anti-dandruff amino acid shampoo are shown in Table 6, and the preparation method thereof comprises the following steps:

[0177] S1. Clean and disinfect the equipment completely and set aside; pre-mix the C2 phase and set aside; dissolve the D phase in advance and set aside;

[0178] S2. Add the water of phase A1 into a beaker, add the remaining components of phase A1 under stirring, then add phase A2 in sequence and stir evenly;

[0179] S3. Heat to 80-85°C, add phase B in sequence while stirring, stir until completely dissolved, stir at constant temperature for 20 minutes, and then start cooling;

[0180] S4. After cooling to 50-55°C, add the C1 phase in sequence and stir evenly, add the pre-mixed and dissolved C2 phase, stir evenly, and then add the pre-dissolved C3 phase to adjust the pH value;

[0181] S5. After cooling to 45°C, add phase D in sequence and stir until evenly mixed.

[0182] S6. Take samples for testing, and discharge the materials after they pass the testing.

[0183] Table 5

[0184]

[0185]

[0186] Table 6

[0187]

[0188]

[0189] (3) Consumer testing

[0190] 180 male and female volunteers aged 18 to 50 were recruited (the inclusion criteria were healthy volunteers with oily hair, dandruff, and scalp itching), 30 people in each group, and used shampoo once every other day (once every 2 days) for 4 consecutive weeks; they were scored and evaluated in three aspects: hair fluffy, dandruff removal, and itching. The scoring range is 0 to 7 points (7 points for extremely satisfied, 6 points for very satisfied, 5 points for relatively satisfied, 4 points for average feeling, 3 points for not very satisfied, 2 points for very dissatisfied, and 1 point for extremely dissatisfied). The higher the sense of identity, the higher the score; overall satisfaction refers to the proportion of people who scored 5 to 7 points. The results of the consumer test are shown in Tables 7 and 8.

[0191] Table 7 Test results of application example 1

[0192] sample Fluffy hair recognition Anti-dandruff recognition Antipruritic approval Comparative Example (OCT) 88.17％ 84.55％ 80.83％ Embodiment 13 88.44％ 90.02％ 88.16％ Embodiment 15 88.51％ 89.64％ 89.42％ Embodiment 30 88.37％ 85.13％ 87.22％ Embodiment 36 88.35％ 86.99％ 87.28％ Embodiment 47 88.42％ 88.57％ 88.23％

[0193] It can be seen from Table 7 that, compared with the comparative example OCT, the hair fluffiness recognition of Examples 13, 15, 30, 36, and 47 is similar to that of the comparative example OCT; and the anti-dandruff recognition and anti-itching recognition are better than those of OCT.

[0194] Table 8 Test results of application example 2

[0195] sample Fluffy hair recognition Anti-dandruff recognition Antipruritic approval Comparative Example (OCT) 79.12％ 80.25％ 70.21％ Embodiment 13 85.49％ 87.82％ 86.21％ Embodiment 15 86.21％ 85.54％ 87.24％ Embodiment 30 84.23％ 84.33％ 86.34％ Embodiment 36 84.88％ 84.48％ 86.41％ Embodiment 47 85.62％ 85.21％ 86.28％

[0196] It can be seen from Table 8 that, compared with the comparative example OCT, the hair fluffiness recognition, dandruff removal recognition and itching relief recognition of Examples 13, 15, 30, 36 and 47 are all better than those of OCT.

[0197] Comparing the test results of the two formulas, the anti-dandruff volumizing shampoo formula group in Table 7 was better than the anti-dandruff amino acid shampoo formula group in Table 8 in improving the recognition of hair fluffiness and anti-itching.

[0198] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. An anti-dandruff composition based on double barrier repair, characterized in that: The effective ingredients of the anti-dandruff composition include at least two of the following: an extract of Ipomoea batatas, an extract of Polygonum capitatum and an extract of Terminalia chebula.

2. The anti-dandruff composition according to claim 1, characterized in that When the active ingredients are two kinds of extracts of Herba Lysimachiae and Polygonum capitatum, the weight ratio of the Herba Lysimachiae to Polygonum capitatum extracts is 1 to 8:1; Preferably, when the active ingredients are three kinds of extracts of Herba Cibotii, Polygonum capitatum extract and Terminalia chebula extract, the weight ratio of the extracts of Herba Cibotii, Polygonum capitatum extract and Terminalia chebula extract is 1:1:1-8.

3. The anti-dandruff composition according to claim 1, characterized in that The active ingredients also include tropolone; Preferably, when any one of the active ingredients of the Herba Cibotii extract, the Herba Polygonum capitatum extract or the Herba Terminaliae extract is combined with tropolone, the weight ratio of any one of the Herba Cibotii extract, the Herba Polygonum capitatum extract or the Herba Terminaliae extract to tropolone is 1 to 16:1; Preferably, when two active ingredients in the extract of Herba Cibotii, Polygonum capitatum extract or Terminalia chebula extract are combined with tropolone, the weight ratio of the two active ingredients in the extract of Herba Cibotii, Polygonum capitatum extract or Terminalia chebula extract to tropolone is 1-4:1-4:1-2; Preferably, when the Herba Cibotii extract, the Herba Polygoni capitata extract, the Herba Terminaliae extract and the Herba Cibotii are combined, the weight ratio of the Herba Cibotii extract, the Herba Polygoni capitata extract, the Herba Terminaliae extract and the Herba Cibotii is 1-8:1-8:1-32:1-10.

4. The anti-dandruff composition according to claim 3, characterized in that The active ingredient further comprises OCT, and the OCT is combined with at least two active ingredients selected from the group consisting of an extract of Herba Cibotii, an extract of Polygonum capitatum, an extract of Terminalia chebula, or tropolone; Preferably, the weight ratio of the sum of at least two active ingredients of the extract of Ipomoea batatas, the extract of Polygonum capitatum, the extract of Terminalia chebula or the extract of Tropolone to OCT is 1:1; Preferably, when two active ingredients of the Herba Cibotii extract, the Herba Polygoni Capitis extract, the Herba Terminaliae extract or the Herba Cibotii are combined with OCT, the weight ratio of the two active ingredients of the Herba Cibotii extract, the Herba Polygoni Capitis extract, the Herba Terminaliae extract or the Herba Cibotii extract to OCT is 1:1:2; Preferably, when the Herba Cibotii extract, the Herba Polygoni Capitis extract, the Herba Terminaliae extract and OCT are combined, the weight ratio of the Herba Cibotii extract, the Herba Polygoni Capitis extract, the Herba Terminaliae extract and OCT is 1:1:1-4:3-6; Preferably, when two active ingredients in the extract of Herba Cibotii, Polygonum capitatum extract or Terminalia chebula extract are combined with tropolone and OCT, the weight ratio of the two active ingredients in the extract of Herba Cibotii, Polygonum capitatum extract or Terminalia chebula extract to tropolone and OCT is 1:1:1-2:3-4; Preferably, when the Herba Cibotii extract, the Herba Polygoni Capitis extract, the Herba Terminaliae extract, the Herba Cibotii extract and the OCT are combined, the weight ratio of the Herba Cibotii extract, the Herba Polygoni Capitis extract, the Herba Terminaliae extract, the Herba Cibotii extract and the OCT is 1:1:1-4:1-6:4-12; Preferably, the extract of Ampelopsis pilosula includes at least one of an extract of the whole plant of Ampelopsis pilosula, an extract of the leaves of Ampelopsis pilosula, or an extract of the stem of Ampelopsis pilosula; Preferably, the terminalia chebula extract comprises at least one of a terminalia chebula whole plant extract, a terminalia chebula fruit extract, a terminalia chebula root extract or a terminalia chebula bark extract.

5. The method for preparing the anti-dandruff composition according to any one of claims 1 to 4, characterized in that: The solution of each component is measured and mixed according to the formula to prepare the product.

6. The preparation method according to claim 5, characterized in that: The preparation methods of the extract of Herba Cibotii, Polygonum capitatum and Terminalia chebula include taking raw materials, adding 4 to 12 times the mass of extracting solution, immersing and ultrasonically extracting, and concentrating the filtrate; Preferably, the extract comprises 30% to 70% alcohol solution or water; Preferably, the alcohol solution comprises an ethanol solution or a butanediol solution; Preferably, the soaking time is 30-90 min, preferably 60 min; Preferably, the ultrasonic time is 20 to 60 minutes, preferably 20 minutes; Preferably, the number of immersion and ultrasonic extraction is 1 to 2 times, and the filtrates are combined and concentrated.

7. Use of the anti-dandruff composition according to any one of claims 1 to 4 or the anti-dandruff composition prepared by the preparation method according to claim 5 or 6 in preparing a product for repairing a damaged scalp barrier.

8. The use according to claim 7, characterized in that: The barrier comprises an antimicrobial barrier and / or an antioxidant barrier.

9. The use according to claim 7, characterized in that: The products include hair washing products or hair care products.

10. A product for repairing a damaged scalp barrier, characterized in that: The invention comprises the anti-dandruff composition according to any one of claims 1 to 4 or the anti-dandruff composition prepared by the preparation method according to claim 5 or 6.

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