Anti-crack repairing composition containing artemisia apiacea and camellia-seed oil as well as preparation and application of anti-crack repairing composition

Abstract

The invention particularly relates to an anti-crack repairing composition containing artemisia apiacea and camellia-seed oil as well as preparation and application of the anti-crack repairing composition, and belongs to the technical field of cosmetics. According to the invention, allantoin, phenoxyethanol, ethylhexylglycerin, an artemisia apiacea extract, urea, tocopherol, camellia seed oil, PEG / PPG-14 / 7 dimethyl ether, cholesteryl polyether-10, a purslane extract, a dandelion extract, grape seed oil, squalane, caprylic acid / capric triglyceride, bis (lauramide glutamine) sodium lysine, glycerin, butanediol and carrageenan are adopted. The composition is prepared from the raw materials, the sodium carboxymethyl cellulose and the water together, and all the raw materials are matched with one another, so that the composition has excellent chap-resisting, skin repairing and nursing, anti-inflammatory and soothing effects and also has better stability and safety effects.

Description

Technical Field

[0001] The invention specifically relates to an anti-crack repairing composition containing artemisia annua and camellia seed oil and a preparation method and application thereof, and belongs to the technical field of cosmetics. Background Art

[0002] Chapped skin refers to the symptom of small cracks on the skin caused by dry skin. Chapped skin often occurs in the most exposed parts of the human body, such as lips, ears, fingers, back of hands, etc. This symptom may occur not only in cold winter, but also in very hot weather. When the cracks are deep, blood will seep out and there will be pain.

[0003] Artemisia annua is a herbaceous plant of the genus Artemisia in the Asteraceae family. It is also known as yellow artemisia, grass artemisia, stinking artemisia, and artemisia argyi. Artemisia annua is rich in artemisinin, artemisinic acid, methyl artemisinate, artemisininol, etc. It also contains ingredients such as volatile oils, flavonoids and coumarins. Artemisia annua extract can moisturize and soothe, and help repair damaged skin barriers. Artemisia annua volatile oil has an inhibitory effect on a variety of pathogens and can be used in the development of acne-removing products. Artemisinin in Artemisia annua has an inhibitory effect on a variety of bacteria and can be used in the development of antibacterial and anti-inflammatory products. In addition, it also has a whitening effect, can inhibit the production of melanin, and lighten spots.

[0004] Camellia seed oil is rich in unsaturated fatty acids and vitamin E, which help improve the skin barrier function and reduce water loss, thus achieving a moisturizing effect. Camellia seed oil also contains squalene, palmitic acid and other ingredients, which can soften the stratum corneum, promote its metabolism, and make the skin soft and smooth. In addition, the polyphenol compounds in camellia seed oil have strong antioxidant capacity, which can remove free radicals and slow down the aging process of cells. Camellia seed oil also contains ingredients with good permeability such as linolenic acid and linoleic acid, which can penetrate deep into the skin and play a role. It also has a certain antibacterial effect, which is helpful to relieve skin discomfort caused by bacterial infection.

[0005] There are many types of anti-crack repair cosmetic products, but the effects are uneven. While providing anti-crack effects, more functions need to be provided. Therefore, it is particularly important to provide a multifunctional anti-crack repair skin composition. Summary of the invention

[0006] In view of the above technical problems, the inventors proposed the solution of the present invention, which specifically comprises an anti-crack repair composition containing Artemisia annua and camellia seed oil, and the preparation and application thereof.

[0007] In one aspect, the present invention provides an anti-crack repair composition containing Artemisia annua and camellia oil, wherein the raw materials are composed of the following in terms of mass percentage: 0.05-1% allantoin, 0.005-0.4% phenoxyethanol, 0.005-0.5% ethylhexylglycerin, 0.005-2% artemisia annua extract, 15-25% urea, 0.1-2% tocopherol, 0.1-1% camellia seed oil, 1-4% PEG / PPG-14 / 7 dimethyl ether, 1-3% cholesteryl polyether-10, 0.1-2% purslane extract, 0.1-2% dandelion extract, 2-5% grape seed oil, 1-3% squalane, 1-3% caprylic / capric triglyceride, 1-2.5% sodium di(lauryl glutamine) lysine, 1-5% glycerin, 1-4% butylene glycol, 0.5-2% carrageenan, 0.5-1.5% sodium carboxymethylcellulose and the rest water.

[0008] Preferably, the amount of the Artemisia annua extract is 0.008-1.5% by mass percentage. The Artemisia annua extract used in the present invention can be obtained by conventional extraction process. Not limited to the following process: Artemisia annua extract: crush the dried Artemisia annua leaves (i.e., Artemisia annua leaves), add 30-65wt% ethanol aqueous solution, heat and stir, filter, and dry to obtain the Artemisia annua extract (i.e., Artemisia annua extract).

[0009] Preferably, the amount of camellia oil used is 0.15-0.5% by mass.

[0010] Preferably, the mass ratio of PEG / PPG-14 / 7 dimethyl ether to cholesterol polyether-10 is 1.2-2:1.

[0011] Preferably, the method for preparing the purslane extract comprises the following steps: Step 1: Grind the dried whole plant of Purslane to obtain a pulverized product, add 10-30 times the mass of water of the pulverized product, stir at 50-60° C. for 2-6 hours, and obtain product 1; Step 2: Cool the product 1, add ethanol to adjust the ethanol mass concentration to 65-85%, stir at 45-55°C for 3-7 hours, and cool to obtain product 2; Step 3: Filter the product 2 to obtain a filtrate, and then dry it to obtain the purslane extract.

[0012] Preferably, the preparation method of dandelion extract comprises the following steps: S1: Grind the dried whole dandelion to obtain a pulverized product, add 10-30 times the mass of the pulverized product and a 55-65wt% ethanol aqueous solution, stir at 40-55°C for 3-6 hours, filter, and cool to obtain product 1; S2: Product 1 is concentrated under reduced pressure to 5-20wt% of the mass of product 1 to obtain a concentrate, and an extractant composed of an oil phase and an aqueous phase in a mass ratio of 1:0.2-0.4 in an amount of 15-40 times the mass of the concentrate is added, and the mixture is stirred and extracted at 40-50° C. for 2-5 hours, and then allowed to stand for stratification, and the oil phase obtained by the stratification is taken as product 3; wherein the oil phase is composed of ethyl acetate and cyclohexane in a mass ratio of 1:2-3.5, and the aqueous phase is water; S3: Concentrate the product 3 under reduced pressure until no ethyl acetate and cyclohexane are detected, and then stop the reduced pressure concentration to obtain a dandelion extract.

[0013] Preferably, the mass ratio of the purslane extract to the dandelion extract is 1:0.8-1.5.

[0014] Preferably, the amount of urea used is 18-23% by mass.

[0015] Another aspect of the present invention provides a method for preparing the anti-crack repair composition containing Artemisia annua and camellia seed oil, comprising the steps of mixing the raw materials and sterilizing.

[0016] The present invention also provides the use of the anti-crack repairing composition containing Artemisia annua and camellia seed oil in the preparation of a preparation for preventing or treating skin cracks, wherein the mass percentage of the anti-crack repairing composition containing Artemisia annua and camellia seed oil in the preparation is 1-20%.

[0017] The beneficial effects of the present invention include but are not limited to: The invention adopts allantoin, phenoxyethanol, ethylhexylglycerin, artemisia annua extract, urea, tocopherol, camellia seed oil, PEG / PPG-14 / 7 dimethyl ether, cholesteryl polyether-10, purslane extract, dandelion extract, grape seed oil, squalane, caprylic / capric triglyceride, sodium di(lauroyl glutamine) lysine, glycerin, butylene glycol, carrageenan, sodium carboxymethyl cellulose and water to prepare the anti-crack repair composition. The raw materials cooperate with each other, so that the composition has excellent effect.

[0018] The composition prepared by the present invention has extremely low irritation and high safety; it also has excellent stability at room temperature; after being placed at high temperature, its Zeta potential changes little and still has good stability.

[0019] The present invention uses PEG / PPG-14 / 7 dimethyl ether and cholesteryl polyether-10 to promote each other to improve the stability of the composition. The two act as emulsifiers to produce a compounding effect, so that the emulsification effect of the composition is better and the raw materials in the composition are more evenly dispersed. In the composition system of the present invention, the use of PEG / PPG-14 / 7 dimethyl ether and cholesteryl polyether-10 in a mass ratio of 1.2-2:1 can make the composition have better stability.

[0020] The composition prepared by the present invention can effectively inhibit the expression of inflammatory factors, has excellent anti-inflammatory effect, and makes the skin more comfortable.

[0021] The composition prepared by combining the purslane extract and the dandelion extract prepared by the specific process of the present invention has a better anti-inflammatory effect than the composition using only one of the extracts. The combination of the two can enrich the types of anti-inflammatory factor active ingredients in the composition, complement each other's advantages, and synergistically enhance the anti-inflammatory effect of the composition.

[0022] When the purslane extract is prepared in the present invention, when the ethanol concentration is adjusted to 65-85wt%, the extract has a better anti-inflammatory effect and can impart a higher anti-inflammatory performance to the composition.

[0023] The present invention uses ethyl acetate and cyclohexane as the oil phase to obtain an extractant to extract the dandelion extract. Compared with using only one of them as the oil phase or using other oil phases, the obtained dandelion extract has a better anti-inflammatory effect, and the composition can better relieve inflammation and soothe the skin. The composition using ethyl acetate and cyclohexane in a mass ratio of 1:2-3.5 as the extractant has a better anti-inflammatory effect than compositions with other ratios.

[0024] The composition prepared by the invention can effectively promote the healing of chapped skin and effectively prevent chapped skin.

[0025] The product of the invention has excellent performance and simple preparation process and has good application prospect. DETAILED DESCRIPTION

[0026] The present invention is described in detail below in conjunction with examples, but the present invention is not limited to these examples. Unless otherwise specified, the raw materials in the examples of the present invention are purchased through commercial channels.

[0027] Artemisia annua extract: Crush the dried Artemisia annua leaves (i.e., Artemisia annua) and add 45wt% ethanol aqueous solution (15 times the mass of Artemisia annua) and stir at 65°C and 65rpm for 4.2 hours, filter, and freeze-dry at -42°C to a water content of 2.45wt% to obtain the Artemisia annua extract.

[0028] Tocopherol: Zhengzhou Kangyuan Chemical Products Co., Ltd. Camellia seed oil: Baoji Fangsheng Biological Development Co., Ltd. Grape seed oil: Hubei Xinjiecheng Chemical Technology Co., Ltd. Carrageenan: Shandong Xinxiong Biotechnology Co., Ltd. Sodium carboxymethyl cellulose: Hubei Mingtuo Biotechnology Co., Ltd.

[0029] 1. Preparation of the composition 1. Composition 1 Raw material composition, mass percentage: 0.2% allantoin, 0.1% phenoxyethanol, 0.1% ethylhexylglycerin, 0.7% artemisia annua extract, 20% urea, 0.2% tocopherol, 0.2% camellia seed oil, 3.6% PEG / PPG-14 / 7 dimethyl ether, 2.4% cholesteryl polyether-10, 1.5% purslane extract, 1.8% dandelion extract, 4% grape seed oil, 2% squalane, 2% caprylic / capric triglyceride, 1.8% sodium di(laurylamide glutamine) lysine, 4% glycerol, 3% 1,3-butylene glycol, 1.5% carrageenan, 1% sodium carboxymethyl cellulose and the balance water.

[0030] The mass ratio of PEG / PPG-14 / 7 dimethyl ether and cholesterol polyether-10 is 1.5:1; the mass ratio of purslane extract and dandelion extract is 1:1.2.

[0031] The preparation method of purslane extract comprises the following steps: Step 1: Grind the dried whole plant of Purslane to obtain a pulverized product, add 20 times the mass of water of the pulverized product, stir at 55° C. and 80 rpm for 4 hours, and obtain product 1; Step 2: Product 1 is cooled to room temperature, ethanol is added to adjust the ethanol mass concentration to 75%, stirred at 50°C and 70rpm for 5 hours, and cooled to room temperature to obtain Product 2; Step 3: The product 2 is filtered through a 0.22 μm pore size filter membrane to obtain a filtrate, which is then freeze-dried at -40°C to a water content of 1.92 wt% to obtain the purslane extract.

[0032] The preparation method of dandelion extract comprises the following steps: S1: Grind the dried whole dandelion to obtain a pulverized product, add 60wt% ethanol aqueous solution (22 times the mass of the pulverized product), stir at 50°C and 75rpm for 5 hours, filter through a 1 μm pore size filter membrane to obtain a filtrate, and cool the filtrate to room temperature to obtain product 1; S2: Product 1 is concentrated under reduced pressure at 55°C and 0.0075MPa to a mass of 11.5wt% of product 1 to obtain a concentrate, and an extractant composed of an oil phase and an aqueous phase in a mass ratio of 1:0.3 in an amount 32 times the mass of the concentrate is added, and the mixture is stirred and extracted at 45°C and 60rpm for 4 hours, and then allowed to stand for 2 hours for stratification, and the oil phase obtained by stratification is taken as product 3; wherein the oil phase is composed of ethyl acetate and cyclohexane in a mass ratio of 1:3, and the aqueous phase is water; S3: The product 3 was concentrated under reduced pressure at 50° C. and 0.007 MPa until no ethyl acetate and cyclohexane were detected, and the reduced pressure concentration was stopped to obtain a dandelion extract.

[0033] The preparation method of the composition is as follows: Add water to 60° C., add sodium di(laurylamide glutamine) lysine, PEG / PPG-14 / 7 dimethyl ether, cholesteryl polyether-10, urea, carrageenan, and sodium carboxymethyl cellulose, and stir at 75 rpm for 1 hour to obtain intermediate material 1; Camellia seed oil, ethylhexylglycerin, grape seed oil, squalane, caprylic / capric triglyceride, glycerin, and 1,3-butylene glycol were mixed, heated at 80° C. and stirred at 90 rpm for 0.5 hour to obtain intermediate material 2; The intermediate material 2 was added to the intermediate material 1, stirred at 150 rpm for 0.5 hour, cooled and kept warm at 35°C, allantoin, phenoxyethanol, artemisia annua extract, tocopherol, purslane extract and dandelion extract were added, stirred at 150 rpm for 0.3 hour, sterilized, and the composition was obtained.

[0034] 2. Composition 2 Raw material composition, mass percentage: 0.25% allantoin, 0.15% phenoxyethanol, 0.08% ethylhexylglycerin, 0.75% artemisia annua extract, 22% urea, 0.15% tocopherol, 0.15% camellia seed oil, 4% PEG / PPG-14 / 7 dimethyl ether, 2% cholesteryl polyether-10, 1.8% purslane extract, 1.5% dandelion extract, 3.5% grape seed oil, 2.2% squalane, 2.1% caprylic / capric triglyceride, 1.75% sodium di(laurylamide glutamine) lysine, 3.8% glycerol, 3.2% 1,3-butylene glycol, 1.4% carrageenan, 1.1% sodium carboxymethyl cellulose and the balance water.

[0035] The mass ratio of PEG / PPG-14 / 7 dimethyl ether and cholesterol polyether-10 is 2:1; the mass ratio of purslane extract and dandelion extract is 1:0.83.

[0036] The preparation method of purslane extract comprises the following steps: Step 1: Grind the dried whole plant of Purslane to obtain a pulverized product, add 22 times the mass of water of the pulverized product, stir at 57° C. and 80 rpm for 4.5 hours, and obtain product 1; Step 2: Product 1 was cooled to room temperature, ethanol was added to adjust the ethanol mass concentration to 65%, stirred at 50°C and 70rpm for 5.5 hours, and cooled to room temperature to obtain Product 2; Step 3: The product 2 is filtered through a 0.22 μm pore size filter membrane to obtain a filtrate, which is then freeze-dried at -40°C to a water content of 1.95 wt% to obtain the purslane extract.

[0037] The preparation method of dandelion extract comprises the following steps: S1: Grind the dried whole dandelion to obtain a pulverized product, add 55wt% ethanol aqueous solution (27 times the mass of the pulverized product), stir at 50°C and 75rpm for 5.5 hours, filter with a 1 micron pore size filter membrane to obtain a filtrate, and cool the filtrate to room temperature to obtain product 1; S2: Product 1 is concentrated under reduced pressure at 55°C and 0.0075MPa to a mass of 12.6wt% of product 1 to obtain a concentrate, and an extractant composed of an oil phase and an aqueous phase in a mass ratio of 1:0.0.2 in an amount 38 times the mass of the concentrate is added, and the mixture is stirred and extracted at 45°C and 60rpm for 4.5 hours, and then allowed to stand for 2.5 hours for stratification, and the oil phase obtained by stratification is taken as product 3; wherein the oil phase is composed of ethyl acetate and cyclohexane in a mass ratio of 1:2, and the aqueous phase is water; S3: The product 3 was concentrated under reduced pressure at 50° C. and 0.007 MPa until no ethyl acetate and cyclohexane were detected, and the reduced pressure concentration was stopped to obtain a dandelion extract.

[0038] The preparation method of the composition is as follows: Add water to 58° C., add sodium di(laurylamide glutamine) lysine, PEG / PPG-14 / 7 dimethyl ether, cholesteryl polyether-10, urea, carrageenan, and sodium carboxymethyl cellulose, and stir at 70 rpm for 1.5 hours to obtain intermediate material 1; Camellia seed oil, ethylhexylglycerin, grape seed oil, squalane, caprylic / capric triglyceride, glycerin, and 1,3-butylene glycol were mixed, heated at 78° C. and stirred at 90 rpm for 0.4 hours to obtain intermediate material 2; The intermediate material 2 was added to the intermediate material 1, stirred at 150 rpm for 0.6 hours, cooled and kept warm at 37°C, allantoin, phenoxyethanol, artemisia annua extract, tocopherol, purslane extract, and dandelion extract were added, stirred at 150 rpm for 0.4 hours, and sterilized to obtain the composition.

[0039] 3. Composition 3 The difference from composition 1 is that the raw material composition, mass percentage: 0.2% allantoin, 0.1% phenoxyethanol, 0.1% ethylhexylglycerin, 0.7% artemisia annua extract, 20% urea, 0.2% tocopherol, 0.2% camellia seed oil, 6% PEG / PPG-14 / 7 dimethyl ether, 1.5% purslane extract, 1.8% dandelion extract, 4% grape seed oil, 2% squalane, 2% caprylic / capric triglyceride, 1.8% sodium di(lauroyl glutamine) lysine, 4% glycerol, 3% 1,3-butylene glycol, 1.5% carrageenan, 1% sodium carboxymethyl cellulose and the balance water. The rest is the same as composition 1.

[0040] 4. Composition 4 The difference from composition 1 is that the raw material composition, mass percentage: 0.2% allantoin, 0.1% phenoxyethanol, 0.1% ethylhexylglycerin, 0.7% artemisia annua extract, 20% urea, 0.2% tocopherol, 0.2% camellia seed oil, 6% choleth-10, 1.5% purslane extract, 1.8% dandelion extract, 4% grape seed oil, 2% squalane, 2% caprylic / capric triglyceride, 1.8% sodium di(lauroyl glutamine) lysine, 4% glycerol, 3% 1,3-butylene glycol, 1.5% carrageenan, 1% sodium carboxymethyl cellulose and the balance water. The rest is the same as composition 1.

[0041] 5. Composition 5 The difference from composition 1 is: raw material composition, mass percentage: 0.2% allantoin, 0.1% phenoxyethanol, 0.1% ethylhexylglycerin, 0.7% artemisia annua extract, 20% urea, 0.2% tocopherol, 0.2% camellia seed oil, 2% PEG / PPG-14 / 7 dimethyl ether, 4% cholesteryl polyether-10, 1.5% purslane extract, 1.8% dandelion extract, 4% grape seed oil, 2% squalane, 2% caprylic / capric triglyceride, 1.8% sodium di(laurylamide glutamine) lysine, 4% glycerol, 3% 1,3-butylene glycol, 1.5% carrageenan, 1% sodium carboxymethyl cellulose and the balance water. The mass ratio of PEG / PPG-14 / 7 dimethyl ether to cholesteryl polyether-10 is 0.5:1. The rest is the same as composition 1.

[0042] 6. Composition 6 The difference from composition 1 is: raw material composition, mass percentage: 0.2% allantoin, 0.1% phenoxyethanol, 0.1% ethylhexylglycerin, 0.7% artemisia annua extract, 20% urea, 0.2% tocopherol, 0.2% camellia seed oil, 5% PEG / PPG-14 / 7 dimethyl ether, 1% cholesteryl polyether-10, 1.5% purslane extract, 1.8% dandelion extract, 4% grape seed oil, 2% squalane, 2% caprylic / capric triglyceride, 1.8% sodium di(laurylamide glutamine) lysine, 4% glycerol, 3% 1,3-butylene glycol, 1.5% carrageenan, 1% sodium carboxymethyl cellulose and the balance water. The mass ratio of PEG / PPG-14 / 7 dimethyl ether to cholesteryl polyether-10 is 5:1. The rest is the same as composition 1.

[0043] 7. Composition 7 The difference from composition 1 is that the raw material composition, mass percentage: 0.2% allantoin, 0.1% phenoxyethanol, 0.1% ethylhexylglycerin, 0.7% artemisia annua extract, 20% urea, 0.2% tocopherol, 0.2% camellia seed oil, 3.6% PEG / PPG-14 / 7 dimethyl ether, 2.4% cholesteryl polyether-10, 3.3% dandelion extract, 4% grape seed oil, 2% squalane, 2% caprylic / capric triglyceride, 1.8% sodium di(lauroyl glutamine) lysine, 4% glycerol, 3% 1,3-butylene glycol, 1.5% carrageenan, 1% sodium carboxymethyl cellulose and the balance water. The rest is the same as composition 1.

[0044] 8. Composition 8 The difference from composition 1 is that the raw material composition, mass percentage: 0.2% allantoin, 0.1% phenoxyethanol, 0.1% ethylhexylglycerin, 0.7% artemisia annua extract, 20% urea, 0.2% tocopherol, 0.2% camellia seed oil, 3.6% PEG / PPG-14 / 7 dimethyl ether, 2.4% cholesteryl polyether-10, 3.3% purslane extract, 4% grape seed oil, 2% squalane, 2% caprylic / capric triglyceride, 1.8% sodium di(lauroyl glutamine) lysine, 4% glycerol, 3% 1,3-butylene glycol, 1.5% carrageenan, 1% sodium carboxymethyl cellulose and the balance water. The rest is the same as composition 1.

[0045] 9. Composition 9 The difference from composition 1 is that in the purslane extraction method, step 2: product 1 is cooled, ethanol is added, the ethanol mass concentration is adjusted to 40%, stirred at 45-55°C for 3-7 hours, cooled, and product 2 is obtained. The rest is the same as composition 1.

[0046] 10. Composition 10 The difference from composition 1 is that in the dandelion extraction method, chloroform is used to replace ethyl acetate and cyclohexane in the oil phase of S2. The rest is the same as composition 1.

[0047] 11. Composition 11 The difference from composition 1 is that in the dandelion extraction method, the oil phase in S2 only uses ethyl acetate. The rest is the same as composition 1.

[0048] 12. Composition 12 The difference from composition 1 is that in the dandelion extraction method, the oil phase in S2 only uses cyclohexane. The rest is the same as composition 1.

[0049] 13. Composition 13 The difference from composition 1 is that in the dandelion extraction method, the oil phase in S2 is composed of ethyl acetate and cyclohexane in a mass ratio of 1:0.5. The rest is the same as composition 1.

[0050] 14. Composition 14 The difference from composition 1 is that it does not contain purslane extract and dandelion extract, and the rest is the same as composition 1.

[0051] 2. Testing 1. Security testing The above composition was mixed with deionized water in a mass ratio of 5:95, stirred at 50° C. and 300 rpm for 0.5 hour, cooled to room temperature, and a solution was obtained as a sample for safety test.

[0052] 140 healthy volunteers aged 30-45 were selected and randomly divided into 14 groups, with 10 people in each group. The selected area is about 40mm 2 The above samples were added to a spot tester with a depth of about 1 mm, and then attached to the inner side of the forearm of the volunteer's left arm. Light pressure was applied to make it evenly adhere to the skin for 24 hours. The appearance of the skin was observed 30 minutes after the spot tester was removed. The safety of each group of samples to the skin was evaluated according to the evaluation criteria recorded in Table 1. The observation results are shown in Table 2.

[0053] Table 1: Evaluation criteria Degree of reaction grade Skin appearance - 0 Negative reaction ± 1 Suspicious reaction, only slight erythema + 2 Weak positive reaction (erythema reaction); erythema, infiltration, edema, and papules may be present ++ 3 Strong positive reaction (herpes reaction); erythema, infiltration, edema, papules, herpes; reaction may extend beyond the test area +++ 4 Obvious erythema, severe infiltration, edema, confluent blister; reactions beyond the test subjects Table 2: Safety test results Serial number / number of people Level 0 Level 1 Level 2 Level 3 Level 4 Composition 1 10 0 0 0 0 Composition 2 10 0 0 0 0 Composition 3 10 0 0 0 0 Composition 4 10 0 0 0 0 Composition 5 10 0 0 0 0 Composition 6 10 0 0 0 0 Composition 7 10 0 0 0 0 Composition 8 10 0 0 0 0 Composition 9 10 0 0 0 0 Composition 10 10 0 0 0 0 Composition 11 10 0 0 0 0 Composition 12 10 0 0 0 0 Composition 13 10 0 0 0 0 Composition 14 10 0 0 0 0 According to the test results in Table 2, the composition prepared by the present invention has extremely low irritation and high safety.

[0054] 2. Stability test Zeta potential is an important indicator for measuring the stability of a dispersed system. The larger the absolute value of the Zeta potential, the higher the stability of the system. The effects of compositions 1-6 were tested to verify the influence of PEG / PPG-14 / 7 dimethyl ether and cholesteryl polyether-10 on the stability of the compositions.

[0055] The specific test method is: dilute the above composition 1-6 with deionized water to a mass concentration of 2.5%, stir at 300 rpm for 0.5 hours to obtain a sample for stability test, and perform a Zeta potential test on the sample, a conventional Zeta potential; after the conventional Zeta potential test, seal it, place it in a 55°C constant temperature box for 24 hours, and test the Zeta potential again to obtain a high temperature Zeta potential. The results are shown in Table 3.

[0056] Table 3: Stability test Serial number Conventional Zeta Potential / mV High temperature Zeta potential / mV Composition 1 -54.37 -48.28 Composition 2 -52.91 -47.06 Composition 3 -48.24 -43.17 Composition 4 -46.13 -41.36 Composition 5 -49.07 -43.85 Composition 6 -51.42 -45.79 According to the test in Table 3, the composition prepared by the present invention has excellent stability at room temperature; and after high temperature treatment, the Zeta potential changes little and still has good stability.

[0057] According to the test comparison of compositions 1 and 3-4, it can be seen that compared with composition 1, composition 3-4 uses only one of PEG / PPG-14 / 7 dimethyl ether and cholesterol polyether-10, and the absolute value of the Zeta potential of the composition obtained is greater than that of composition 1; thus, it can be seen that the present invention adopts PEG / PPG-14 / 7 dimethyl ether and cholesterol polyether-10 for combination, which can promote each other to improve the stability of the composition. It is speculated that the two may have a compounding effect as emulsifiers, so that the emulsification effect of the composition is better and the raw materials in the composition are more evenly dispersed.

[0058] By changing the mass ratio of PEG / PPG-14 / 7 dimethyl ether and cholesterol polyether-10 in compositions 5-6, the absolute values ​​of the Zeta potential of the obtained compositions are all lower than those of composition 1. In the composition system of the present invention, using PEG / PPG-14 / 7 dimethyl ether and cholesterol polyether-10 in a mass ratio of 1.2-2:1 can make the composition have better stability.

[0059] 3. Anti-inflammatory test Anti-inflammation is an important functional indicator of cosmetics; the test compositions 1-2 and 7-13 of the present invention inhibit inflammation, thereby verifying the influence of purslane extract and dandelion extract on the anti-inflammatory effect of the composition of the present invention, and at the same time verifying the anti-inflammatory effect of purslane extract and dandelion extract obtained by different extraction processes.

[0060] The specific anti-inflammatory test was carried out in accordance with T / SHRH033-2021 "Test for Cosmetic Soothing Efficacy-In Vitro TNF-α Inflammatory Factor Content Determination of Lipopolysaccharide-Induced Macrophage RAW264.7 Test Method", and the amount of TNF-α secreted by macrophage RAW264.7 was tested; among them, the blank group did not add LPS and composition 1-12; the model group only added LPS, and the added concentration was 1 mg / mL; in addition to adding LPS (added concentration of 1 mg / mL) to the composition 1-13 group, composition 1-12 was added in sequence (composition 1-12 was added at a concentration of 10wt%). The content of TNF-α inflammatory factor in each group was statistically obtained; at the same time, the reduction in the content of TNF-α inflammatory factor in each group compared with the model group was calculated; the test results are shown in Table 4.

[0061] Table 4: Anti-inflammatory test Serial number TNF-α / ng / mL Reduction compared to the model group / ng / mL Blank Group 0.77 16.79 Model Group 17.56 0 Composition 1 9.13 8.43 Composition 2 9.58 7.98 Composition 7 10.24 7.32 Composition 8 10.83 6.73 Composition 9 10.15 7.41 Composition 10 11.52 6.04 Composition 11 10.91 6.65 Composition 12 10.37 7.19 Composition 13 9.72 7.84 Composition 14 14.09 3.47 According to the test results in Table 4, the composition prepared by the present invention can effectively inhibit the expression of inflammatory factors, has excellent anti-inflammatory effect, and makes the skin more comfortable.

[0062] According to the comparison of the test results of compositions 1, 7-8, it can be seen that composition 1 prepared by combining purslane extract and dandelion extract prepared by the specific process of the present invention has better anti-inflammatory effect than compositions 7 and 8 using only one of the extracts. The combination of the two enriches the types of active anti-inflammatory factors in the composition, complements each other's advantages, and synergizes to enhance the anti-inflammatory effect of the composition.

[0063] According to the comparison between compositions 1 and 9, the extract obtained by extracting the purslane extract when the ethanol concentration is adjusted to too low in step 2 during the extraction has a relatively poor anti-inflammatory effect. When the purslane extract is prepared by the present invention, when the ethanol concentration is adjusted to 65-85wt%, the extract has a better anti-inflammatory effect and can give the composition higher anti-inflammatory performance.

[0064] According to the test results of compositions 1 and 14, it can be seen that the purslane extract and the dandelion extract can give the composition excellent anti-inflammatory effects. From the comparison of compositions 1, 10-13, it can be seen that the present invention uses ethyl acetate and cyclohexane as the oil phase to obtain the extractant to extract the dandelion extract 1. Compared with using only one of them as the oil phase or using other oil phases (such as chloroform), the obtained dandelion extract has a better anti-inflammatory effect, which can make the composition better at anti-inflammatory and soothing the skin. And composition 1 using ethyl acetate and cyclohexane in a mass ratio of 1:2-3.5 as the extractant has a better anti-inflammatory effect than composition 13 with other ratios.

[0065] 4. Anti-cracking test 40 volunteers with cracked and itchy hands were recruited and randomly divided into 2 groups, 20 in each group, and used composition 1 and 2 respectively; volunteers in each group applied the corresponding composition to the cracked and itchy parts once in the morning and evening every day; follow-up visits were conducted on the 10th and 25th days of use to observe the apparent condition of the hands of volunteers in each group, and the skin condition of the volunteers' hands was evaluated according to three levels: cured (skin cracks disappeared), effective (cracks were improved) and ineffective (basically no change). The statistical results of the number of people corresponding to each level at different times are shown in Table 5.

[0066] Table 5: Anti-cracking test

[0067] According to the test results in Table 5, the composition prepared by the present invention can effectively promote the healing of chapped skin and effectively prevent chapped skin.

[0068] The above are only embodiments of the present invention. The protection scope of the present invention is not limited by these specific embodiments, but is determined by the claims of the present invention. For those skilled in the art, the present invention can have various changes and variations. Any modification, equivalent replacement, improvement, etc. made within the technical ideas and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. An anti-crack repair composition containing Artemisia annua and camellia oil, characterized in that: According to mass percentage, the raw material composition is: 0.05-1% allantoin, 0.005-0.4% phenoxyethanol, 0.005-0.5% ethylhexylglycerin, 0.005-2% artemisia annua extract, 15-25% urea, 0.1-2% tocopherol, 0.1-1% camellia seed oil, 1-4% PEG / PPG-14 / 7 dimethyl ether, 1-3% cholesteryl polyether-10, 0.1-2% purslane extract, 0.1-2% dandelion extract, 2-5% grape seed oil, 1-3% squalane, 1-3% caprylic / capric triglyceride, 1-2.5% sodium di(lauryl glutamine) lysine, 1-5% glycerin, 1-4% butylene glycol, 0.5-2% carrageenan, 0.5-1.5% sodium carboxymethylcellulose and the rest water.

2. The anti-crack repair composition containing Artemisia annua and camellia oil according to claim 1, characterized in that: In terms of mass percentage, the dosage of Artemisia annua extract is 0.008-1.5%.

3. The anti-crack repair composition containing Artemisia annua and camellia oil according to claim 1, characterized in that: In terms of mass percentage, the dosage of camellia oil is 0.15-0.5%.

4. The anti-crack repair composition containing Artemisia annua and camellia oil according to claim 1, characterized in that: The mass ratio of PEG / PPG-14 / 7 dimethyl ether and cholesterol polyether-10 is 1.2-2:

1.

5. The anti-crack repair composition containing Artemisia annua and camellia oil according to claim 1, characterized in that: The mass ratio of purslane extract to dandelion extract is 1:0.8-1.

5.

6. The anti-crack repair composition containing Artemisia annua and camellia oil according to claim 1, characterized in that: According to mass percentage, the amount of urea used is 18-23%.

7. A method for preparing the anti-crack repair composition containing Artemisia annua and camellia oil according to any one of claims 1 to 6, characterized in that: The process includes mixing and sterilizing the raw materials.

8. Use of the anti-crack repairing composition containing Artemisia annua and camellia seed oil according to any one of claims 1 to 6 in the preparation of a preparation for preventing or treating skin chapped skin, characterized in that: The mass percentage of the anti-crack repair composition containing Artemisia annua and camellia seed oil in the preparation is 1-20%.

9. The anti-crack repair composition containing Artemisia annua and camellia oil according to any one of claims 1 to 6, or the preparation method according to claim 7, or the use according to claim 8, characterized in that: The preparation method of purslane extract comprises the following steps: Step 1: Grind the dried whole plant of Purslane to obtain a pulverized product, add 10-30 times the mass of water of the pulverized product, stir at 50-60° C. for 2-6 hours, and obtain product 1; Step 2: Cool the product 1, add ethanol to adjust the ethanol mass concentration to 65-85%, stir at 45-55°C for 3-7 hours, and cool to obtain product 2; Step 3: Filter the product 2 to obtain a filtrate, and then dry it to obtain the purslane extract.

10. The anti-crack repair composition containing Artemisia annua and camellia oil according to any one of claims 1 to 6, or the preparation method according to claim 7, or the use according to claim 8, characterized in that: The preparation method of dandelion extract comprises the following steps: S1: Grind the dried whole dandelion to obtain a pulverized product, add 10-30 times the mass of the pulverized product and a 55-65wt% ethanol aqueous solution, stir at 40-55°C for 3-6 hours, filter, and cool to obtain product 1; S2: Product 1 is concentrated under reduced pressure to 5-20wt% of the mass of product 1 to obtain a concentrate, and an extractant composed of an oil phase and an aqueous phase in a mass ratio of 1:0.2-0.4 in an amount of 15-40 times the mass of the concentrate is added, and the mixture is stirred and extracted at 40-50° C. for 2-5 hours, and then allowed to stand for stratification, and the oil phase obtained by the stratification is taken as product 3; wherein the oil phase is composed of ethyl acetate and cyclohexane in a mass ratio of 1:2-3.5, and the aqueous phase is water; S3: Concentrate the product 3 under reduced pressure until no ethyl acetate and cyclohexane are detected, and then stop the reduced pressure concentration to obtain a dandelion extract.

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