Medicine for treating scald infection as well as preparation method and application thereof

Through the self-assembly of tetrahedral framework nucleic acid and antibiotic neomycin sulfate, the tFNAs-NeoS complex is formed, which solves the antibiotic toxic side effects and drug resistance problems in scald infection treatment, and achieves efficient and safe scald healing effect.

CN119925399AActive Publication Date: 2025-05-06SICHUAN UNIV
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Patent Information

Application Number
CN202510064818.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-01-15
Publication Date
2025-05-06
Estimated Expiration
2045-01-15

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to a medicine for treating scald infection and a preparation method and application thereof. The invention discloses a medicine for treating scald infection. The medicine is prepared by self-assembling tetrahedral framework nucleic acid and antibiotics. The tFNAs-NeoS medicine is preferably selected, and the preparation method of the medicine is simple; the loading efficiency of the neomycin sulfate is high; the stability in a complex biological medium is good; the tFNAs-NeoS reduces the cytotoxicity and the effective dose of the antibiotic NeoS, and has better biological safety than the tFNAs; the generation of bacterial drug resistance is retarded. In the aspect of treating scald wound infection, the tFNAs-NeoS has a better effect of promoting wound healing and better biological safety than NeoS. Therefore, the tFNAs-NeoS prepared by the invention overcomes the problem of overuse of antibiotics, and has a good clinical application prospect.
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Citation Information

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