Vein nutrient solution formula for promoting lactation and fattening of animals and preparation method

Abstract

The invention relates to the technical field of intravenous nutrient solutions, in particular to a formula of an intravenous nutrient solution for promoting lactation and fattening of animals and a preparation method, and the formula of the intravenous nutrient solution comprises a fat emulsion, an amino acid solution, an electrolyte solution, a glucose solution, a calcium source solution, a phosphorus source solution, multivitamins and sterile water. The preparation method of the intravenous nutrient solution for promoting lactation and fattening of animals comprises the following steps: step 1, preparing raw materials; 2, dissolving and mixing; step 3, adjusting the pH value; step 4, filtering and sub-packaging; step 5, sterilization treatment; according to the method, the nutrient solution can be injected through the vein to effectively make up for insufficient nutrition of animals in the natural ingestion state, the injected nutrient solution does not need the digestion and absorption capacity of the animals, the nutrient solution directly enters blood, full-value nutrition is rapidly supplemented for the animals, the nutritional requirements of the animals in the lactation and fattening process are met, lactation is promoted, fattening is accelerated, and the survival rate of the animals is increased. The animal production performance is greatly improved.

Description

Technical Field

[0001] The invention relates to the technical field of intravenous nutrient solution, in particular to a formula of intravenous nutrient solution for promoting animal lactation and fattening and a preparation method thereof. Background Art

[0002] China is a country with a large population and a large livestock breeding industry. The improvement of people's living standards calls for the development of the livestock breeding industry. In 2023, China's cattle breeding volume will reach 105.0851 million heads, the number of live pig stocks will be 434.22 million heads, the number of sheep stocks will be 322.33 million, pork production will be 57.94 million tons, and poultry meat production will be 25.63 million tons, an increase of 1.2 million tons over the previous year. The production of beef will be 7.53 million tons, the production of mutton will be 5.31 million tons, the production of milk will be 41.97 million tons, and the production of poultry eggs will be 35.63 million tons.

[0003] After animals eat feed, part of it is digested and absorbed through the gastrointestinal tract, enters the liver for metabolism, and synthesizes animal fat, protein and milk in the body, while part of it cannot be digested and absorbed and is excreted in the form of feces. The feed often consumes a certain amount of energy in the process of digestion and absorption through the gastrointestinal tract. In production practice, due to the limited or restricted gastrointestinal volume of animals, animals are often unable to eat too much feed, which makes it difficult for animals to achieve maximum production performance, especially lactating cows and lactating sows. In order to increase the milk production of lactating cows and lactating sows, people try every means to increase the feed intake of lactating cows and lactating sows. However, it is often difficult to significantly increase the feed intake of lactating cows and lactating sows. Therefore, if the complete nutrients of the feed can be injected into the blood without entering the gastrointestinal tract and directly reach the liver for metabolic synthesis, it can not only reduce the energy consumption of gastrointestinal nutrient absorption, but also improve animal production performance. Summary of the invention

[0004] The present invention aims to solve the problems of insufficient animal feed intake, high energy consumption of gastrointestinal nutrient absorption and low animal production performance, and provides a fat emulsion, amino acid solution, electrolyte solution, glucose, calcium source solution, phosphorus source solution, complex vitamins and other biologically active nutrients, which contains not only fat and protein but also carbohydrates, minerals and vitamins, and can quickly supplement full nutrition for animals. The present invention has the characteristics of high fat content, high soluble protein content, high electrolyte solution content, low glucose content, aseptic purification, low anti-nutritional factor content, good effect of promoting animal lactation and fattening, and the like, and is an intravenous nutrient solution for lactation and fattening.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: a formula of intravenous nutrient solution for promoting animal lactation and fattening, wherein the configuration ratio of the intravenous nutrient solution for lactation and fattening is as follows by weight percentage: 0.1% to 10% fat emulsion, 0.05% to 5.0% amino acid solution, 0.2% to 20.0% electrolyte solution, 0.05% to 5.0% glucose solution, 0.05% to 0.1% calcium source solution, 0.025% to 0.05% phosphorus source solution, 0.025% to 0.05% complex vitamins, and 65% to 85% sterile water.

[0006] A method for preparing intravenous nutrient solution for promoting animal lactation and fattening, comprising step 1: raw material preparation; step 2: dissolution and mixing; step 3: pH value adjustment; step 4: filtration and subpackaging; step 5: sterilization treatment;

[0007] In the above step 1, the staff weighed 80 kg of fat emulsion, 40 kg of amino acid solution, 192 kg of electrolyte solution, 40 kg of glucose solution, 0.8 kg of calcium source solution, 0.32 kg of phosphorus source solution, 0.32 kg of multivitamins, and 1246.56 kg of sterile water according to the proportion;

[0008] In the above step 2, 2.5m 3 After cleaning the stainless steel stirring tank with a capacity of 1246.56 kg, first add all the 1246.56 kg sterile water into the stirring tank, start stirring, mix 40 kg of amino acid solution and 40 kg of glucose solution evenly, then add 80 kg of fat emulsion, slowly add 192 kg of electrolyte solution, stir while adding, then dissolve 0.32 kg of multivitamins, 0.8 kg of calcium source solution, and 0.32 kg of phosphorus source solution in the nutrient solution in sequence, stir and mix for 1 hour, so that the materials are fully dissolved to obtain 1600 kg of nutrient solution;

[0009] In the above step 3, a pH meter is used to detect the pH value of the nutrient solution, and a pH adjuster is selected according to the pH value detection result, and the addition amount of the selected pH adjuster is calculated according to the pH value of the selected pH adjuster, and a certain amount of the pH adjuster is diluted with sterile water and gradually added to the nutrient solution to adjust the pH value of the nutrient solution to maintain it in a weak alkaline range close to neutral;

[0010] In the above step 4, the nutrient solution with a weakly alkaline pH value close to neutral is added to a precision filter for filtration to remove particles and impurities. The filtered nutrient solution is divided into 1600 sterile injection bottles at 1 kg per bottle and sealed for storage.

[0011] In the above step 5, all 1600 sterile injection bottles containing non-sterile nutrient solution are placed in a horizontal sterilizer and steam is introduced to perform high temperature and high pressure sterilization.

[0012] Preferably, in step 1, the electrolyte solution components include sodium chloride and potassium chloride.

[0013] Preferably, in step 1, the calcium source solution is selected from one of calcium chloride, calcium gluconate and calcium lactate.

[0014] Preferably, in step 1, the phosphorus source solution is potassium dihydrogen phosphate.

[0015] Preferably, in step three, a pH adjuster is selected. When the pH meter detects that the pH value of the nutrient solution exceeds 7.45, an acid adjuster is selected, such as citric acid or potassium dihydrogen phosphate. When the pH meter detects that the pH value of the nutrient solution is lower than 7.35, an alkali adjuster is selected, such as sodium hydroxide or sodium bicarbonate.

[0016] Preferably, in step five, the sterilization temperature is 80° C. to 160° C., and the insulation time is 6 to 120 minutes.

[0017] Compared with the prior art, the beneficial effects of the present invention are as follows: the nutrient solution is intravenously injected, which is quickly absorbed and utilized by tissue cells throughout the body, effectively making up for the nutritional deficiencies of animals in a natural feeding state, and the injected nutrient solution does not require the digestion and absorption capacity of the animal itself, but directly enters the blood and is quickly absorbed and utilized by the animal, thereby avoiding digestive tract absorption disorders and improving nutrient utilization. The nutrient solution contains not only fat emulsion and amino acid solution, but also glucose, electrolyte solution, calcium source solution, phosphorus source solution and compound vitamins, which can quickly supplement full nutrition for animals and meet the nutritional needs of animals during lactation and fattening. The electrolyte solution can supplement body fluids and electrolytes in the animal, the calcium source solution and the phosphorus source solution can maintain blood calcium and blood phosphorus levels, promote bone health and lactation, and the compound vitamins can promote the secretion of prolactin and growth hormone, thereby increasing milk production and growth rate, accelerating fattening, and greatly improving animal production performance.

[0018] By adjusting the pH value of the solution to ensure that the nutrient solution is maintained in a weak alkaline range close to neutrality, it can maintain physiological balance, promote nutrient absorption and utilization, enhance immune function, optimize lactation performance, and promote fat synthesis and accumulation for animal lactation and fattening, thereby improving animal production performance;

[0019] Weakly alkaline intravenous nutrient solution helps dissolve and transport nutrients, making calcium source solution, phosphorus source solution and vitamins easier to be absorbed by the body in a weakly alkaline environment, thereby improving the bioavailability of nutrients; weakly alkaline intravenous nutrient solution injected into the animal body can optimize the animal body's energy metabolism process in a weakly alkaline environment, improve the conversion efficiency of feed, and help the animal body to more effectively utilize the ingested nutrients, thereby increasing body weight and milk production; weakly alkaline environment can optimize the animal body's energy metabolism process and improve the conversion efficiency of feed; this means that the animal body can more effectively utilize the ingested nutrients, thereby increasing body weight and milk production; weakly alkaline environment also helps optimize the composition of milk, including protein, fat and lactose, improve the nutritional value of milk and meet the growth needs of the cub; in a weakly alkaline environment, the synthesis and accumulation activities of fat cells can proceed normally. This means that the animal body can more effectively convert the ingested nutrients into adipose tissue, thereby increasing body weight and body fat percentage; and by adjusting the pH value of the intravenous nutrient solution to change the existence form of ions in the calcium source solution and the phosphorus source solution, the calcium source solution and the phosphorus source solution are not easy to form precipitation. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 The present invention is a flow chart for preparing intravenous nutrient solution. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] 1. Please refer to Figure 1 , a technical solution provided by the present invention:

[0023] Embodiment 1:

[0024] The invention discloses a formula of intravenous nutrient solution for promoting animal lactation and fattening. The configuration proportions of the intravenous nutrient solution for lactation and fattening are as follows by weight: 5% fat emulsion, 2.5% amino acid solution, 12% electrolyte solution, 2.5% glucose solution, 0.05% calcium source solution, 0.02% phosphorus source solution, 0.02% complex vitamins, and 77.91% sterile water.

[0025] A method for preparing intravenous nutrient solution for promoting animal lactation and fattening, comprising step 1: raw material preparation; step 2: dissolution and mixing; step 3: pH value adjustment; step 4: filtration and subpackaging; step 5: sterilization treatment;

[0026] In the above step 1, the staff weighed 80 kg of fat emulsion, 40 kg of amino acid solution, 192 kg of electrolyte solution, 40 kg of glucose solution, 0.8 kg of calcium source solution, 0.32 kg of phosphorus source solution, 0.32 kg of multivitamins, and 1246.56 kg of sterile water according to the proportion;

[0027] In the above step 2, 2.5m 3 After cleaning the stainless steel stirring tank with a capacity of 1246.56 kg, first add all the 1246.56 kg of sterile water into the stirring tank and start stirring, mix 40 kg of amino acid solution and 40 kg of glucose solution evenly to form a basic nutrient solution, confirm that there is no precipitation, then add 80 kg of fat emulsion, slowly add 192 kg of electrolyte solution to the basic nutrient solution, stirring while adding to ensure that the electrolytes are evenly distributed, and then dissolve 0.32 kg of multivitamins, 0.8 kg of calcium source solution, and 0.32 kg of phosphorus source solution in the nutrient solution, respectively, stir and mix for 1 hour to ensure that the components are evenly distributed, and then use a homogenizer to homogenize the mixture to improve the stability and dispersibility of the fat emulsion, so that the materials are fully dissolved to obtain 1600 kg of nutrient solution;

[0028] In the above step 3, a pH meter is used to detect the pH value of the nutrient solution. When the pH meter detects that the pH value of the nutrient solution is not in the range of 7.35 to 7.45, a pH adjuster is selected according to the pH value test result, and the addition amount is calculated according to the pH value of the selected pH adjuster, as follows:

[0029] When the pH meter detects that the pH value of the nutrient solution exceeds 7.45, choose an acid adjuster, such as citric acid, which has a pH value of 2;

[0030] The initial pH value of the nutrient solution detected by the pH meter is marked as [H+] initial , the hydrogen ion concentration is: [H+] initial =10 -Y mol / L, where Y is the initial value of the nutrient solution detected by the pH meter;

[0031] The target pH value of the nutrient solution is marked as [H+] final , assuming the target pH value of the nutrient solution is 7.4, the hydrogen ion concentration of the nutrient solution with a target pH value of 7.4 is: [H+] final =10 -7.4 mol / L;

[0032] Calculate the change in hydrogen ion concentration: Δ[H+] = [H+] final -[H+] initial , that is, Δ[H+]=10 -7.4 -10 -Y Mole / L

[0033] Assuming the amount of citric acid to be added is x kg, the concentration of the citric acid solution is

[0034] Since citric acid has a pH of 2, its hydrogen ion concentration is 10 -2 moles / liter; Assuming that the density of citric acid solution is similar to that of water (1 kg / liter), the number of moles of hydrogen ions provided by x kg of citric acid is x×10 -2 Mole / L

[0035] Distribute hydrogen ions evenly into 1600+x kg of nutrient solution, and the hydrogen ion concentration changes to:

[0036]

[0037] The above hydrogen ion concentration change is compared with the calculated Δ[H + ] are equal, and we can solve for:

[0038]

[0039] Citric acid is diluted with sterile water, and the pH value of the nutrient solution is adjusted by adding the diluted citric acid. Citric acid can combine with the calcium source solution to form an easily absorbed chelate, which prevents calcium from combining with phosphate ions to form precipitation. Citric acid can participate in the tricarboxylic acid cycle in animals and indirectly provide energy for the animal body. In addition, citric acid, as a coenzyme or cofactor in biochemical reactions, participates in the metabolism and utilization of nutrients. Therefore, the citric acid component in intravenous nutrient solution helps to provide comprehensive nutritional support for mammals.

[0040] When the pH meter detects that the pH value of the nutrient solution is lower than 7.35, select an alkaline adjuster, such as sodium hydroxide or sodium bicarbonate, and calculate the amount of the alkaline adjuster to be added according to the specific pH value of the selected alkaline adjuster through the above steps. Dilute the calculated amount of pH adjuster with sterile water and gradually add it to the nutrient solution while stirring. At the same time, the pH meter continuously monitors the change of pH value to ensure that the nutrient solution is maintained in a weak alkaline range close to neutral;

[0041] Dilute the calculated amount of pH adjuster with an appropriate amount of sterile water, and gradually add it to the nutrient solution, stirring while adding. At the same time, the pH meter continuously monitors the change of pH value, and avoids adding too much adjuster at one time to avoid excessive fluctuation of pH value. Ensure that the nutrient solution is maintained in a weak alkaline range close to neutrality, and change the existence form of ions by adjusting the pH value of the solution, so that it is not easy to form precipitation;

[0042] In the above step 4, the nutrient solution with a pH value adjusted to the range of 7.35 to 7.45 is added to a precision filter for filtration to remove particles and impurities. The filtered nutrient solution is divided into 1600 sterile injection bottles at 1 kg per bottle and sealed for storage.

[0043] In the above step 5, all 1600 sterile injection bottles containing unsterilized nutrient solution are placed in a horizontal sterilizer, steam is introduced for high temperature and high pressure sterilization, the temperature reaches 120°C, and 120°C is maintained for 30 minutes, so as to obtain 1600 bottles of sterile purified lactation and fattening intravenous nutrient solution with a specification of 1kg / bottle. High temperature and high pressure sterilization can kill microorganisms in the nutrient solution and ensure the sterility of the nutrient solution.

[0044] Furthermore, in step one, the electrolyte solution components include sodium chloride, potassium chloride and multiple electrolytes. During the lactation and fattening process of animals, a large amount of body fluids and electrolytes may be lost in the animal body due to physiological activities and metabolic needs. The electrolyte solution can quickly replenish body fluids and electrolytes to maintain the water and electrolyte balance in the animal body and ensure normal physiological functions.

[0045] Furthermore, in step one, the calcium source solution is selected from one of calcium chloride, calcium gluconate, and calcium lactate. During the lactation and fattening process of animals, a large amount of calcium ions may be lost in the animal body due to physiological activities and metabolic needs. The calcium source solution in the intravenous nutrient solution component can quickly replenish the lost calcium ions, maintain blood calcium levels, promote bone health and lactation, and supplement the calcium source solution to promote animal bone growth and development and improve bone strength and density.

[0046] Calcium ions mainly play a buffering role in the acid-base balance. When the acidic substances in the body increase, calcium ions can combine with the acidic substances to form compounds such as acid-calcium salts, thereby reducing the acidity in the body. Conversely, when the alkaline substances in the body increase, calcium ions can also react with the alkaline substances to regulate the alkalinity in the body.

[0047] Furthermore, in step one, potassium dihydrogen phosphate is selected as the phosphorus source solution. During the lactation and fattening process of animals, the demand for phosphorus increases. Intravenous infusion of potassium dihydrogen phosphate can quickly supplement phosphorus, maintain blood phosphorus levels, promote bone development and lactation, and supplement phosphorus to promote animal energy metabolism and improve production performance.

[0048] Embodiment 2:

[0049] The invention discloses a formula of intravenous nutrient solution for promoting animal lactation and fattening. The configuration proportions of the intravenous nutrient solution for lactation and fattening are as follows by weight: 5% fat emulsion, 2.5% amino acid solution, 12% electrolyte solution, 2.5% glucose solution, 0.05% calcium source solution, 0.02% phosphorus source solution, 0.02% complex vitamins, and 77.91% sterile water.

[0050] A method for preparing intravenous nutrient solution for promoting animal lactation and fattening, comprising step 1: raw material preparation; step 2: dissolution and mixing; step 3: pH value adjustment; step 4: filtration and subpackaging; step 5: sterilization treatment;

[0051] In the above step 1, the staff weighed 80 kg of fat emulsion, 40 kg of amino acid solution, 192 kg of electrolyte solution, 40 kg of glucose solution, 0.8 kg of calcium source solution, 0.32 kg of phosphorus source solution, 0.32 kg of multivitamins, and 1246.56 kg of sterile water according to the proportion;

[0052] In the above step 2, 2.5m 3 After cleaning the stainless steel stirring tank with a capacity of 1246.56 kg, first add all the 1246.56 kg of sterile water into the stirring tank and start stirring, mix 40 kg of amino acid solution and 40 kg of glucose solution evenly to form a basic nutrient solution, confirm that there is no precipitation, then add 80 kg of fat emulsion, slowly add 192 kg of electrolyte solution to the basic nutrient solution, stirring while adding to ensure that the electrolytes are evenly distributed, and then dissolve 0.32 kg of multivitamins, 0.8 kg of calcium source solution, and 0.32 kg of phosphorus source solution in the nutrient solution, respectively, stir and mix for 1 hour to ensure that the components are evenly distributed, and then use a homogenizer to homogenize the mixture to improve the stability and dispersibility of the fat emulsion, so that the materials are fully dissolved to obtain 1600 kg of nutrient solution;

[0053] In the above step 3, a pH meter is used to detect the pH value of the nutrient solution. When the pH meter detects that the pH value of the nutrient solution is not in the range of 7.35 to 7.45, a pH adjuster is selected according to the pH value test result, and the addition amount is calculated according to the pH value of the selected pH adjuster, as follows:

[0054] When the pH meter detects that the pH value of the nutrient solution exceeds 7.45, choose an acid adjuster, such as citric acid, which has a pH value of 2;

[0055] The initial pH value of the nutrient solution detected by the pH meter is marked as [H+] initial , the hydrogen ion concentration is: [H+] initial =10 -Y mol / L, where Y is the initial value of the nutrient solution detected by the pH meter;

[0056] The target pH value of the nutrient solution is marked as [H+] final , assuming the target pH value of the nutrient solution is 7.4, the hydrogen ion concentration of the nutrient solution with a target pH value of 7.4 is: [H+] final =10 -7.4 mol / L;

[0057] Calculate the change in hydrogen ion concentration: Δ[H+] = [H+] final -[H+] initial , that is, Δ[H+]=10 -7.4 -10 -Y Mole / L

[0058] Assuming the amount of citric acid to be added is x kg, the concentration of the citric acid solution is

[0059] Since citric acid has a pH of 2, its hydrogen ion concentration is 10 -2 moles / liter; Assuming that the density of citric acid solution is similar to that of water (1 kg / liter), the number of moles of hydrogen ions provided by x kg of citric acid is x×10 -2 Mole / L

[0060] Distribute hydrogen ions evenly into 1600+x kg of nutrient solution, and the hydrogen ion concentration changes to:

[0061]

[0062] The above hydrogen ion concentration change is compared with the calculated Δ[H + ] are equal, and we can solve for:

[0063]

[0064] The calculated amount of citric acid is diluted with sterile water, and the pH value of the nutrient solution is adjusted by adding the diluted citric acid;

[0065] When the pH meter detects that the pH value of the nutrient solution is lower than 7.35, select an alkaline adjuster, such as sodium hydroxide or sodium bicarbonate, and calculate the amount of the alkaline adjuster to be added according to the specific pH value of the selected alkaline adjuster through the above steps. Dilute the calculated amount of pH adjuster with sterile water and gradually add it to the nutrient solution while stirring. At the same time, the pH meter continuously monitors the change of pH value to ensure that the nutrient solution is maintained in a weak alkaline range close to neutral;

[0066] Dilute the calculated amount of pH adjuster with an appropriate amount of sterile water, and gradually add it to the nutrient solution, stirring while adding. At the same time, the pH meter continuously monitors the change of pH value, and avoids adding too much adjuster at one time to avoid excessive fluctuation of pH value. Ensure that the nutrient solution is maintained in a weak alkaline range close to neutrality, and change the existence form of ions by adjusting the pH value of the solution, so that it is not easy to form precipitation;

[0067] In the above step 4, the nutrient solution with a pH value adjusted to the range of 7.35 to 7.45 is added to a precision filter for filtration to remove particles and impurities. The filtered nutrient solution is divided into 1600 sterile injection bottles at 1 kg per bottle and sealed for storage.

[0068] In the above step 5, all 1600 sterile injection bottles containing unsterilized nutrient solution are placed in a horizontal sterilizer, steam is introduced for high temperature and high pressure sterilization, the temperature reaches 105°C, and 105°C is maintained for 40 minutes, so as to obtain 1600 bottles of sterile purified lactation and fattening intravenous nutrient solution with a specification of 1kg / bottle. High temperature and high pressure sterilization can kill microorganisms in the nutrient solution and ensure the sterility of the nutrient solution.

[0069] Embodiment 3:

[0070] The invention discloses a formula of intravenous nutrient solution for promoting animal lactation and fattening. The configuration proportions of the intravenous nutrient solution for lactation and fattening are as follows by weight: 4% fat emulsion, 2% amino acid solution, 10% electrolyte solution, 2% glucose solution, 0.05% calcium source solution, 0.02% phosphorus source solution, 0.02% complex vitamins, and 81.91% sterile water.

[0071] A method for preparing intravenous nutrient solution for promoting animal lactation and fattening, comprising step 1: raw material preparation; step 2: dissolution and mixing; step 3: pH value adjustment; step 4: filtration and subpackaging; step 5: sterilization treatment;

[0072] In the above step 1, the staff weighed 86.4 kg of fat emulsion, 43.2 kg of amino acid solution, 216 kg of electrolyte solution, 43.2 kg of glucose solution, 1.08 kg of calcium source solution, 0.432 kg of phosphorus source solution, 0.432 kg of multivitamins, and 1769.256 kg of sterile water according to the proportion;

[0073] In the above step 2, 2.5m 3After cleaning the stainless steel stirring tank with a capacity of 1769.256 kg, first add all the 1769.256 kg of sterile water into the stirring tank and start stirring, mix 43.2 kg of amino acid solution and 43.2 kg of glucose solution evenly to form a basic nutrient solution, confirm that there is no precipitation, then add 86.4 kg of fat emulsion, slowly add 192 kg of electrolyte solution to the basic nutrient solution, stirring while adding to ensure that the electrolytes are evenly distributed, and then dissolve 0.432 kg of multivitamins, 1.08 kg of calcium source solution, and 0.432 kg of phosphorus source solution in the nutrient solution, respectively, stir and mix for 1 hour to ensure that the components are evenly distributed, and then use a homogenizer to homogenize the mixture to improve the stability and dispersibility of the fat emulsion, so that the materials are fully dissolved to obtain 2160 kg of nutrient solution;

[0074] In the above step 3, a pH meter is used to detect the pH value of the nutrient solution. When the pH meter detects that the pH value of the nutrient solution is not in the range of 7.35 to 7.45, a pH adjuster is selected according to the pH value test result, and the addition amount is calculated according to the pH value of the selected pH adjuster, as follows:

[0075] When the pH meter detects that the pH value of the nutrient solution exceeds 7.45, choose an acid adjuster, such as citric acid, which has a pH value of 2;

[0076] The initial pH value of the nutrient solution detected by the pH meter is marked as [H+] initial , the hydrogen ion concentration is: [H+] initial =10 -Y mol / L, where Y is the initial value of the nutrient solution detected by the pH meter;

[0077] The target pH value of the nutrient solution is marked as [H+] final , assuming the target pH value of the nutrient solution is 7.4, the hydrogen ion concentration of the nutrient solution with a target pH value of 7.4 is: [H+] final =10 -7.4 mol / L;

[0078] Calculate the change in hydrogen ion concentration: Δ[H+] = [H+] final -[H+] initial , that is, Δ[H+]=10 -7.4 -10 -Y Mole / L

[0079] Assuming the amount of citric acid to be added is x kg, the concentration of the citric acid solution is

[0080] Since citric acid has a pH of 2, its hydrogen ion concentration is 10 -2 moles / liter; Assuming that the density of citric acid solution is similar to that of water (1 kg / liter), the number of moles of hydrogen ions provided by x kg of citric acid is x×10-2 Mole / L

[0081] Distribute hydrogen ions evenly into 2160+x kg of nutrient solution, and the hydrogen ion concentration changes to:

[0082]

[0083] The above hydrogen ion concentration change is compared with the calculated Δ[H + ] are equal, and we can solve for:

[0084]

[0085] The calculated amount of citric acid is diluted with sterile water, and the pH value of the nutrient solution is adjusted by adding the diluted citric acid;

[0086] When the pH meter detects that the pH value of the nutrient solution is lower than 7.35, select an alkaline adjuster, such as sodium hydroxide or sodium bicarbonate, and calculate the amount of the alkaline adjuster to be added according to the specific pH value of the selected alkaline adjuster through the above steps. Dilute the calculated amount of pH adjuster with sterile water and gradually add it to the nutrient solution while stirring. At the same time, the pH meter continuously monitors the change of pH value to ensure that the nutrient solution is maintained in a weak alkaline range close to neutral;

[0087] In the above step 4, the nutrient solution with a pH value adjusted to the range of 7.35 to 7.45 is added to a precision filter for filtration to remove particles and impurities therein, and the filtered nutrient solution is divided into 2160 sterile injection bottles at 1 kg per bottle and sealed for storage.

[0088] In the above step five, all 2160 sterile injection bottles containing unsterilized nutrient solution are placed in a horizontal sterilizer, steam is introduced for high-temperature and high-pressure sterilization, the temperature reaches 120°C, and 120°C is maintained for 30 minutes to obtain 2160 bottles of sterile purified intravenous nutrient solution for lactation and fattening with a specification of 1kg / bottle; high-temperature and high-pressure sterilization can kill microorganisms in the nutrient solution and ensure the sterility of the nutrient solution.

[0089] Embodiment 4:

[0090] The invention discloses a formula of intravenous nutrient solution for promoting animal lactation and fattening. The configuration proportions of the intravenous nutrient solution for lactation and fattening are as follows by weight: 4% fat emulsion, 2% amino acid solution, 10% electrolyte solution, 2% glucose solution, 0.05% calcium source solution, 0.02% phosphorus source solution, 0.02% complex vitamins, and 81.91% sterile water.

[0091] A method for preparing intravenous nutrient solution for promoting animal lactation and fattening, comprising step 1: raw material preparation; step 2: dissolution and mixing; step 3: pH value adjustment; step 4: filtration and subpackaging; step 5: sterilization treatment;

[0092] In the above step 1, the staff weighed 86.4 kg of fat emulsion, 43.2 kg of amino acid solution, 216 kg of electrolyte solution, 43.2 kg of glucose solution, 1.08 kg of calcium source solution, 0.432 kg of phosphorus source solution, 0.432 kg of multivitamins, and 1769.256 kg of sterile water according to the proportion;

[0093] In the above step 2, 2.5m 3 After cleaning the stainless steel mixing tank with a capacity of 1769.256 kg, first add all the 1769.256 kg sterile water, start stirring, mix 43.2 kg of amino acid solution and 43.2 kg of glucose solution evenly to form a basic nutrient solution, confirm that there is no precipitation, then add 86.4 kg of fat emulsion, slowly add 192 kg of electrolyte solution to the basic nutrient solution, stirring while adding to ensure that the electrolytes are evenly distributed, and then dissolve 0.432 kg of multivitamins, 1.08 kg of calcium source solution, and 0.432 kg of phosphorus source solution in the nutrient solution, respectively, stir and mix for 1 hour to ensure that the components are evenly distributed, and then use a homogenizer to homogenize the mixture to improve the stability and dispersibility of the fat emulsion, so that the materials are fully dissolved to obtain 2160 kg of nutrient solution;

[0094] In the above step 3, a pH meter is used to detect the pH value of the nutrient solution, and a pH adjuster is selected according to the pH value detection result, and the addition amount is calculated according to the pH value of the selected pH adjuster, as follows:

[0095] When the pH meter detects that the pH value of the nutrient solution exceeds 7.45, choose an acid adjuster, such as citric acid, which has a pH value of 2;

[0096] The initial pH value of the nutrient solution detected by the pH meter is marked as [H+] initial , the hydrogen ion concentration is: [H+] initial =10 -Y mol / L, where Y is the initial value of the nutrient solution detected by the pH meter;

[0097] The target pH value of the nutrient solution is marked as [H+] final , assuming the target pH value of the nutrient solution is 7.4, the hydrogen ion concentration of the nutrient solution with a target pH value of 7.4 is: [H+] final =10 -7.4 mol / L;

[0098] Calculate the change in hydrogen ion concentration: Δ[H+] = [H+] final-[H+] initial , that is, Δ[H+]=10 -7.4 -10 -Y Mole / L

[0099] Assuming the amount of citric acid to be added is x kg, the concentration of the citric acid solution is

[0100] Since citric acid has a pH of 2, its hydrogen ion concentration is 10 -2 moles / liter; Assuming that the density of citric acid solution is similar to that of water (1 kg / liter), the number of moles of hydrogen ions provided by x kg of citric acid is x×10 -2 Mole / L

[0101] Distribute hydrogen ions evenly into 2160+x kg of nutrient solution, and the hydrogen ion concentration changes to:

[0102]

[0103] The above hydrogen ion concentration change is compared with the calculated Δ[H + ] are equal, and we can solve for:

[0104]

[0105] The calculated amount of citric acid is diluted with sterile water, and the pH value of the nutrient solution is adjusted by adding the diluted citric acid;

[0106] When the pH meter detects that the pH value of the nutrient solution is lower than 7.35, select an alkaline adjuster, such as sodium hydroxide or sodium bicarbonate, and calculate the amount of the alkaline adjuster to be added according to the specific pH value of the selected alkaline adjuster through the above steps. Dilute the calculated amount of pH adjuster with sterile water and gradually add it to the nutrient solution while stirring. At the same time, the pH meter continuously monitors the change of pH value to ensure that the nutrient solution is maintained in a weak alkaline range close to neutral;

[0107] In the above step 4, the nutrient solution with a pH value adjusted to the range of 7.35 to 7.45 is added to a precision filter for filtration to remove particles and impurities therein, and the filtered nutrient solution is divided into 2160 sterile injection bottles at 1 kg per bottle and sealed for storage.

[0108] In the above step five, all 2160 sterile injection bottles containing unsterilized nutrient solution are placed in a horizontal sterilizer, steam is introduced for high-temperature and high-pressure sterilization, the temperature reaches 105°C, and 105°C is maintained for 40 minutes to obtain 2160 bottles of sterile purified intravenous nutrient solution for lactation and fattening with a specification of 1kg / bottle; high-temperature and high-pressure sterilization can kill microorganisms in the nutrient solution and ensure the sterility of the nutrient solution.

[0109] The weight comparison of ingredients in each embodiment is as follows:

[0110]

[0111]

[0112] Among the above ingredients, fat emulsion can provide an additional source of energy, which helps animals to lactate and fatten; it helps the absorption and utilization of fat-soluble vitamins; amino acid solution, which constitutes the basic unit of protein, promotes milk synthesis and muscle growth, and also has the function of buffering and regulating pH, which helps to maintain the stability of fat emulsion; electrolyte solution, which maintains the water and electrolyte balance in the animal body and ensures normal physiological function; potassium chloride; glucose solution, which provides energy for the body; calcium source solution, which also helps to maintain the normal function of nerves and muscles; phosphorus source solution, which helps to maintain the acid-base balance and energy metabolism in the body; multivitamins, which supplement the vitamins needed by various animals, improve the immunity, disease resistance and production performance of animals, help to improve mammary gland function and promote milk secretion.

[0113] 2. Analysis of the application effect of the intravenous nutrient solution for lactation and fattening prepared in the above embodiment

[0114] Among them, the application effect of the intravenous nutrient solution for lactation and fattening prepared in Example 1 on lactating sows.

[0115] 1. Determination of production performance of lactating sows

[0116] (1) Intravenous nutrient solution infusion for lactation and fattening

[0117] 160 Landrace×Large White dual-purpose multiparous sows with similar parity, body condition and expected delivery date were randomly selected and randomly divided into a control group and an experimental group; each group had 8 replicates, and each replicate had 10 sows; the diet and nutritional level of the control group and the experimental group were completely consistent; the intravenous nutrition injection time of the experimental group was 12.0 hours / day (h / d), the intravenous nutrition solution injection amount was 10 kilograms / day (kg / d), and the intravenous nutrition solution was prepared according to the scheme of Example 1.

[0118] (2) Determination of production performance of lactating sows

[0119] The average feed intake of lactating sows, the average daily weight gain of lactating piglets, the average diarrhea rate of lactating piglets and the average survival rate of lactating piglets were measured.

[0120] 2. Data Statistical Analysis

[0121] SPSS22.0 statistical software was used for one-way ANOVA, and the LSD method was used for multiple comparisons. The data results were expressed as "mean ± standard deviation"; P < 0.05 indicated a significant difference.

[0122] 3. Effect of intravenous nutrient solution on lactating sows to promote animal lactation and fattening

[0123] 3.1 Effects of intravenous nutrition solution for promoting animal lactation and fattening on the production performance of lactating sows

[0124] As shown in Table 1, compared with the control group, after lactating sows were given intravenous nutrition solution to promote animal lactation and fattening, the daily weight gain of piglets aged 1 to 23 days was significantly increased by 59.82% (P < 0.0001), the survival rate of piglets aged 23 days was increased by 4.68%, and the estrus rate of sows 7 days after weaning was increased by 11.13%. However, the daily average feed intake and constipation rate of lactating sows were not significantly affected, and no significant differences were found; the results show that intravenous nutrition solution to promote animal lactation and fattening can significantly improve the production performance of lactating sows.

[0125] Table 1 Effects of intravenous infusion of milky instant complete nutrient solution on production performance of lactating sows

[0126]

[0127] Among them, the application effect of the intravenous nutrient solution for lactation and fattening prepared in Example 4 on lactating dairy cows.

[0128] 1. Determination of production performance of lactating dairy cows

[0129] (1) Intravenous nutrient solution infusion for lactation and fattening

[0130] 120 Holstein cows with similar parity, body condition and expected delivery date were randomly selected, with 2 to 4 parities and lactation of about 80 to 90 days, and were randomly divided into a control group and an experimental group; each group had 6 replicates, and each replicate had 10 cows. The diet and nutritional level of the control group and the experimental group were completely consistent; the intravenous nutrition injection time of the experimental group was 12 hours / day (h / d), the intravenous nutrition solution injection amount of intravenous lactation fattening was 18 kilograms / day (kg / d), and the intravenous nutrition solution for lactation fattening was prepared by the scheme of Example 4.

[0131] (2) Determination of production performance of lactating dairy cows

[0132] The average feed intake, average milk production, milk fat content, milk protein content and lactose content of lactating dairy cows were determined.

[0133] 2. Data Statistical Analysis

[0134] SPSS22.0 statistical software was used for one-way ANOVA, and the LSD method was used for multiple comparisons. The data results were expressed as "mean ± standard deviation"; P < 0.05 indicated a significant difference.

[0135] 3. The application effect of intravenous nutrient solution for promoting animal lactation and fattening on lactating dairy cows

[0136] 3.1 Effects of intravenous nutrient solution for promoting animal lactation and fattening on the production performance of lactating dairy cows

[0137] As can be seen from Table 2, compared with the control group, after the intravenous nutrient solution for promoting animal lactation and fattening of lactating dairy cows, the milk production of dairy cows on days 1 to 8 was extremely significantly increased by 28.68% (P < 0.005), the milk production of dairy cows on days 9 to 16 was extremely significantly increased by 33.68% (P < 0.005), and the milk production of dairy cows on days 17 to 24 was extremely significantly increased by 37.55% (P < 0.005); the results show that the intravenous nutrient solution for promoting animal lactation and fattening can extremely significantly improve the production performance of lactating dairy cows.

[0138] Table 2 Effects of intravenous infusion of milky instant complete nutrient solution on production performance of lactating dairy cows

[0139]

[0140] As can be seen from Table 3, compared with the control group, after lactating dairy cows were given intravenous nutrition solution to promote animal lactation and fattening, the milk fat content in the milk increased by 8.80% (P<0.05), the milk protein content in the milk increased by 4.70%, but not significantly (P>0.05), and the lactose content in the milk increased by 4.55% (P>0.05), but not significantly (P>0.05); the results show that intravenous nutrition solution to promote animal lactation and fattening can improve the quality of milk.

[0141] Table 3 Effects of intravenous infusion of milky instant complete nutrient solution on milk composition of lactating cows

[0142]

[0143] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

Claims

1. A formula of intravenous nutrient solution for promoting animal lactation and fattening, characterized in that: The configuration proportions of the intravenous nutrient solution for lactation and fattening are as follows by weight: fat emulsion 0.1%-10%, amino acid solution 0.05%-5.0%, electrolyte solution 0.2%-20.0%, glucose solution 0.05%-5.0%, calcium source solution 0.05%-0.1%, phosphorus source solution 0.025%-0.05%, multivitamins 0.025%-0.05%, and sterile water 65%-85%.

2. A method for producing intravenous nutrient solution for promoting animal lactation and fattening, comprising step 1: raw material preparation; step 2: dissolution and mixing; step 3: pH value adjustment; step 4: filtration and subpackaging; step 5: sterilization treatment; In the above step 1, the staff weighed 80 kg of fat emulsion, 40 kg of amino acid solution, 192 kg of electrolyte solution, 40 kg of glucose solution, 0.8 kg of calcium source solution, 0.32 kg of phosphorus source solution, 0.32 kg of multivitamins, and 1246.56 kg of sterile water according to the proportion; In the above step 2, 2.5m 3 After cleaning the stainless steel stirring tank with a capacity of 1246.56 kg, first add all the 1246.56 kg sterile water into the stirring tank, start stirring, mix 40 kg of amino acid solution and 40 kg of glucose solution evenly, then add 80 kg of fat emulsion, slowly add 192 kg of electrolyte solution, stir while adding, then dissolve 0.32 kg of multivitamins, 0.8 kg of calcium source solution, and 0.32 kg of phosphorus source solution in the nutrient solution in sequence, stir and mix for 1 hour, so that the materials are fully dissolved to obtain 1600 kg of nutrient solution; In the above step 3, a pH meter is used to detect the pH value of the nutrient solution, and a pH adjuster is selected according to the pH value detection result, and the addition amount of the selected pH adjuster is calculated according to the pH value of the selected pH adjuster, and a certain amount of the pH adjuster is diluted with sterile water and gradually added to the nutrient solution to adjust the pH value of the nutrient solution to maintain it in a weak alkaline range close to neutral; In the above step 4, the nutrient solution with a weakly alkaline pH value close to neutral is added to a precision filter for filtration to remove particles and impurities. The filtered nutrient solution is divided into 1600 sterile injection bottles at 1 kg per bottle and sealed for storage. In the above step 5, all 1600 sterile injection bottles containing non-sterile nutrient solution are placed in a horizontal sterilizer and steam is introduced to perform high temperature and high pressure sterilization.

3. The method for producing an intravenous nutrient solution for promoting animal lactation and fattening according to claim 2, characterized in that: In step 1, the electrolyte solution components include sodium chloride, potassium chloride and other electrolytes.

4. The method for producing an intravenous nutrient solution for promoting animal lactation and fattening according to claim 2, characterized in that: In the step 1, the calcium source solution is selected from one of calcium chloride, calcium gluconate and calcium lactate.

5. The method for producing an intravenous nutrient solution for promoting animal lactation and fattening according to claim 2, characterized in that: In the step 1, potassium dihydrogen phosphate is selected as the phosphorus source solution.

6. The method for producing an intravenous nutrient solution for promoting animal lactation and fattening according to claim 2, characterized in that: In step three, a pH adjuster is selected. When the pH meter detects that the pH value of the nutrient solution exceeds 7.45, an acid adjuster is selected, such as citric acid or potassium dihydrogen phosphate. When the pH meter detects that the pH value of the nutrient solution is lower than 7.35, an alkali adjuster is selected, such as sodium hydroxide or sodium bicarbonate.

7. The method for producing an intravenous nutrient solution for promoting animal lactation and fattening according to claim 2, characterized in that: In step 5, the sterilization temperature is 80° C. to 160° C., and the insulation time is 6 to 120 minutes.

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