Traditional Chinese medicine formula for treating irregular menstruation

Abstract

The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine formula for treating irregular menstruation, which is mainly prepared from the following components: 10-20g of cobra, 8-12g of ligusticum wallichii, 10-20g of caulis spatholobi, 8-12g of angelica sinensis, 10-20g of radix paeoniae alba, 10-20g of radix curcumae and 10g of fructus liquidambaris. The traditional Chinese medicine is prepared from cobra, ligusticum wallichii, caulis spatholobi, angelica sinensis, radix paeoniae alba, radix curcumae and fructus liquidambaris, has a considerable curative effect on irregular menstruation, takes effect quickly, is safe and reliable after being taken for a long time, and has no toxic or side effect.

Description

[Technical field]

[0001] The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine prescription for treating irregular menstruation. [Background technology]

[0002] In the current treatment of irregular menstruation, Western medicine advocates the supplementation of progesterone, but there is still no unified view on the dosage. In traditional Chinese medicine, irregular menstruation belongs to the category of "uneven menstruation" and is caused by factors such as yin deficiency and hyperactivity of fire, weak qi and blood, and spleen and kidney qi deficiency. The treatment is often based on promoting blood circulation and removing blood stasis, relaxing meridians and activating collaterals, and regulating qi and blood; but the traditional method of simply supplementing qi and blood is slow to take effect and cannot achieve satisfactory treatment results.

[0003] Therefore, there is an urgent need to develop a new Chinese medicine formula for treating irregular menstruation with considerable efficacy, quick effect, and no toxic side effects to make up for the above-mentioned defects. [Summary of the invention]

[0004] The technical problem to be solved by the present invention is achieved by adopting the following technical solutions:

[0005] A traditional Chinese medicine prescription for treating menstrual disorders is mainly prepared from the following components: 10-20 grams of cobra, 8-12 grams of chuanxiong, 10-20 grams of millettia reticulata, 8-12 grams of angelica, 10-20 grams of white peony root, 10-20 grams of curcuma and 10 grams of rhizoma smilacis Glabrae.

[0006] Preferably, a traditional Chinese medicine prescription for treating irregular menstruation is mainly composed of the following components: 15 grams of cobra, 10 grams of Chuanxiong, 15 grams of Millettia reticulata, 10 grams of Angelica sinensis, 15 grams of white peony root, 15 grams of Curcuma aromatica, and 10 grams of Smilax glabra.

[0007] Preferably, the Chinese medicine formula for treating irregular menstruation is prepared into an oral preparation.

[0008] Preferably, the oral preparation of the TCM formula for treating irregular menstruation is one of a decoction, an oral liquid, a granule, a tablet, a capsule, and a pill.

[0009] Preferably, the present invention provides a use of the above-mentioned Chinese medicine formula in the preparation of a medicine for treating irregular menstruation.

[0010] Preferably, the present invention provides a traditional Chinese medicine preparation for treating menstrual disorders, which is composed of the above-mentioned traditional Chinese medicine formula and pharmaceutically acceptable excipients.

[0011] Preferably, the dosage form of the Chinese medicine preparation is ointment, granules, pills, powders, tablets, capsules or oral liquid.

[0012] Preferably, the pharmaceutically acceptable excipient is selected from at least one of a solvent, a diluent, a disintegrant, a precipitation inhibitor, a surfactant, a glidant, a binder, a lubricant, a dispersant, a suspending agent, an isotonic agent, a thickener, an emulsifier, a preservative, a stabilizer, a hydrating agent, an emulsification accelerator, a buffer, an absorbent, a colorant, a flavoring agent, a sweetener, an ion exchanger, a release agent, a coating agent, a flavoring agent or an antioxidant.

[0013] The drug mechanism of the drug raw materials used in the present invention is as follows:

[0014] Cobra: Sweet, salty, warm in nature; enters the liver and kidney meridians. Has the effect of dispelling wind, unblocking meridians and relieving pain. Commonly used for rheumatic pain, stroke paralysis, and polio.

[0015] Chuanxiong: pungent, warm. Enters the liver meridian, gallbladder meridian, and pericardium meridian. It promotes qi and relieves depression, dispels wind and dampness, and promotes blood circulation and relieves pain. It is used to treat wind-cold headache, dizziness, dystocia, postpartum blood stasis and pain, carbuncle, ulcer, irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to mass, stabbing pain in the chest and ribs, swelling and pain due to falls, and rheumatic pain. It is used for irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to mass, stabbing pain in the chest and ribs, swelling and pain due to falls, headache, and rheumatic pain.

[0016] Millettia reticulata: bitter; slightly sweet; warm in nature. Mainly used to promote blood circulation and relax muscles, nourish blood and regulate menstruation; mainly used to treat numbness of hands and feet, paralysis of limbs, rheumatic pain, irregular menstruation, dysmenorrhea, and amenorrhea. Mainly used to treat numbness of hands and feet, paralysis of limbs, rheumatic pain, irregular menstruation, dysmenorrhea, and amenorrhea.

[0017] Angelica: sweet, pungent, bitter, warm in nature. Treats irregular menstruation, amenorrhea, abdominal pain, mass accumulation, metrorrhagia, headache due to blood deficiency, dizziness, paralysis, constipation due to dry intestines, heaviness after dysentery, carbuncle, sore, and injuries from falls.

[0018] White peony root: bitter, sour, slightly cold. Enters the liver meridian and spleen meridian. Indications: chest, abdomen, rib pain, diarrhea, abdominal pain, spontaneous sweating, night sweats, yin deficiency fever, irregular menstruation, metrorrhagia, leucorrhea.

[0019] Curcuma: pungent, bitter, cold. Enters the liver, heart, and lung meridians. Has the effects of promoting blood circulation and relieving pain, promoting qi and relieving depression, clearing the heart and cooling blood, promoting bile and relieving jaundice. Used for chest and flank pain, chest obstruction and heart pain, amenorrhea and dysmenorrhea, breast pain, febrile coma, epilepsy, vomiting and bleeding due to blood heat, jaundice and red urine.

[0020] Rhizoma Lulutong: bitter; neutral. Enters the liver meridian and kidney meridian. Mainly used to dispel wind and dredge collaterals, promote diuresis and remove dampness. Treats limb pain, cramps in hands and feet, stomachache, edema, distension, amenorrhea, oligolactosis, carbuncle, hemorrhoid fistula, scabies, and eczema.

[0021] Due to the adoption of the above technical scheme, the present invention has the following beneficial effects: the present invention adopts cobra, chuanxiong, millettia, angelica, white peony root, curcuma and rhizoma liquidambar as raw materials, has considerable curative effect, quick effect, is safe and reliable for long-term use, and has no toxic side effects. [Specific implementation method]

[0022] The following embodiments may help those skilled in the art to more fully understand the present invention, but shall not limit the present invention in any way.

[0023] A traditional Chinese medicine prescription for treating menstrual disorders is mainly prepared from the following components: 10-20 grams of cobra, 8-12 grams of chuanxiong, 10-20 grams of millettia reticulata, 8-12 grams of angelica, 10-20 grams of white peony root, 10-20 grams of curcuma and 10 grams of rhizoma smilacis Glabrae.

[0024] Example 1

[0025] A traditional Chinese medicine prescription for treating irregular menstruation is mainly prepared from the following components: 15 grams of cobra, 10 grams of chuanxiong, 15 grams of millettia reticulata, 10 grams of angelica, 15 grams of white peony root, 15 grams of curcuma, and 10 grams of rhizoma smilacis asiatica.

[0026] A method for preparing a traditional Chinese medicine prescription for treating irregular menstruation, comprising the following steps:

[0027] (1) Preparation: Weigh the ingredients of the formula according to the weight ratio, rinse and dry the cobra, chuanxiong, millettia, angelica, white peony root, curcuma, and liquidambar formosana respectively, and set aside for later use;

[0028] (2) Decoction: add 3-5 times the amount of water as the raw material, decoct over low heat for 30-40 minutes, filter, and obtain 200-300 ml of filtrate, which is the TCM formula for treating irregular menstruation.

[0029] Comparative Example 1

[0030] 15 grams of black-necked snake, 10 grams of Chuanxiong, 15 grams of Millettia reticulata, 10 grams of Angelica sinensis, 15 grams of white peony root, 15 grams of Curcuma aromatica, and 10 grams of Rhizoma Smilacis Glabrae.

[0031] A method for preparing a traditional Chinese medicine prescription for treating irregular menstruation, comprising the following steps:

[0032] (1) Preparation: Weigh the ingredients of the formula according to the weight ratio, rinse and dry the black-necked snake, selfheal, clematis, aconite, turmeric, and zedoaria respectively for later use;

[0033] (2) Decoction: add 3-5 times the amount of water as the raw material, decoct over low heat for 30-40 minutes, filter, and obtain 200-300 ml of reference filtrate.

[0034] Comparative Example 2

[0035] This comparative example provides a traditional Chinese medicine formula for treating irregular menstruation, and its raw material composition is different from that of Example 1 in that Bupleurum is used instead of Chuanxiong.

[0036] Comparative Example 3

[0037] This comparative example provides a traditional Chinese medicine formula for treating irregular menstruation, and its raw material composition is different from that of Example 1 in that Ligustrum lucidum is used instead of Curcuma aromatica.

[0038] Experimental Example 1

[0039] The safety of the traditional Chinese medicine formula for treating irregular menstruation provided in Example 1 and Comparative Examples 1-3 was investigated, and 1 ml of the composition prepared in each group was weighed and set aside;

[0040] Thirty-five male and female mice (18-22 g) were selected, and 1 ml of the test substance was given by oral gavage once after fasting for 16 hours, and then observed for 24 hours.

[0041] The results showed that there was no death in each group of mice within 24 hours of administration. After administration, the mice had normal appearance, fur color, and luster, and their social behavior and reactions were normal, and their feeding and excretion were normal. After 24 hours, the mice were artificially killed and dissected, and the main organs such as the heart, liver, spleen, lung, and kidney were observed with the naked eye. The results showed that no abnormal phenomena such as organ enlargement, atrophy, and necrosis were found. This shows that the TCM prescriptions provided in Example 1 and Comparative Examples 1-3 are safe and reliable.

[0042] Experimental Example 2

[0043] The clinical application effects of the Chinese medicine compositions for regulating irregular menstruation provided in Example 1 and Comparative Examples 1-3 were investigated, and 140 patients with irregular menstruation aged 25-40 years old were recruited, who met the TCM diagnosis of kidney deficiency as the basis, and were related to qi and blood deficiency and functional disorders of the liver, spleen and other organs.

[0044] Patients with menopausal syndrome, functional uterine bleeding, menstrual disorders caused by organic lesions of reproductive organs, menstrual disorders caused by intrauterine contraceptive devices or tubal ligation, and severe organic damage to the heart, liver, and kidneys were excluded.

[0045] Treatment plan: 120 patients were randomly divided into 4 groups, 30 people in each group, and took the Chinese medicine prescription for treating irregular menstruation provided in Example 1 and Comparative Examples 1-3, twice a day, 50 ml each time, for 3 consecutive menstrual cycles.

[0046] Treatment standards: Drafted with reference to the "Guidelines for Clinical Research of New Chinese Medicines" formulated by the Ministry of Health of the People's Republic of China, the evaluation standards for clinical symptoms and signs are:

[0047] Recovery: pregnancy, normal menstruation, normal follicle development, normal endometrium, normal hormone levels;

[0048] Significantly effective: normal menstruation, normal follicle development, normal endometrium, and normal hormone levels;

[0049] Effective: Menstruation improves, follicle development improves, endometrium thickens, and hormone levels improve;

[0050] Ineffective: Infertility and no improvement in follicular development, thin endometrium, and no hormone changes.

[0051] Total effective rate = (cured + markedly effective + effective) / total number of people.

[0052] Recovered (person) Significantly effective (people) Effective (person) Invalid (person) Total effective rate (%) Example 1 20 5 5 0 100 Comparative Example 1 8 2 5 15 50 Comparative Example 2 3 4 8 15 50 Comparative Example 3 4 6 7 13 56

[0053] Table 1 Clinical results of Chinese herbal composition for regulating irregular menstruation

[0054] As can be seen from the data in Table 1, the Chinese medicine composition for regulating menstrual disorders provided in the embodiment of the present invention has significant therapeutic effects. After treatment for 3 menstrual cycles, the total effective rate is above 90%. Comparative Example 1 uses the black-banded snake with similar efficacy to replace the cobra, Comparative Example 2 uses Bupleurum to replace Chuanxiong, and Comparative Example 3 uses Ligustrum lucidum to replace Curcuma. The results show that the therapeutic effects of Comparative Examples 1-3 are significantly lower than those of Example 1, indicating that although the replaced Chinese medicinal materials have similar efficacy, they cannot play a good role in the composition of the present invention, and may even destroy the overall effect of the prescription, so that the components cannot play a good compatibility relationship according to the principle of monarch, minister, assistant and envoy, thereby resulting in poor therapeutic effect of the composition.

[0055] At the same time, although the garter snake and the cobra belong to the same snake family, the effect of the garter snake in regulating menstrual disorders is obviously not as good as that of the cobra. This shows that not any random snake meat replacement can achieve the effect that the traditional Chinese medicine formula for treating menstrual disorders of the present invention can achieve.

[0056] Although the present invention has been described in detail above with general descriptions and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements may be made thereto based on the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all fall within the scope of protection claimed by the present invention.

Claims

1. A Chinese medicine formula for treating irregular menstruation, characterized in that: It is mainly made of the following ingredients: 10-20 grams of cobra, 8-12 grams of Chuanxiong, 10-20 grams of Millettia reticulata, 8-12 grams of Angelica sinensis, 10-20 grams of white peony, 10-20 grams of Curcuma aromatica, and 10 grams of Rhizoma Smilacis Glabrae.

2. The Chinese medicine prescription for treating irregular menstruation according to claim 1, characterized in that: It is mainly made of the following ingredients: 15 grams of cobra, 10 grams of Chuanxiong, 15 grams of Millettia reticulata, 10 grams of Angelica sinensis, 15 grams of white peony, 15 grams of Curcuma aromatica, and 10 grams of Rhizoma Smilacis Glabrae.

3. The Chinese medicine prescription for treating irregular menstruation according to any one of claims 1 to 2, characterized in that: The traditional Chinese medicine formula for treating irregular menstruation is prepared into an oral preparation.

4. The Chinese medicine prescription for treating irregular menstruation according to claim 3, characterized in that: The oral preparation of the traditional Chinese medicine formula for treating irregular menstruation is one of decoction, oral liquid, granule, tablet, capsule and pill.

5. The method for preparing a traditional Chinese medicine prescription for treating menstrual disorders according to claim 4, characterized in that: The following steps are involved: (1) Preparation: Weigh the ingredients of the formula according to the weight ratio, rinse and dry the cobra, chuanxiong, millettia, angelica, white peony root, curcuma, and liquidambar formosana respectively, and set aside for later use; (2) Decoction: add 3-5 times the amount of water as the raw material, decoct over low heat for 30-40 minutes, filter, and obtain 200-300 ml of filtrate, which is the TCM formula for treating irregular menstruation.