Traditional Chinese medicine composition for treating infantile common cold as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition for treating common cold in children as well as a preparation method and application thereof. The traditional Chinese medicine composition for treating common cold in children is prepared from the following raw materials in parts by weight: 10 to 20 parts of agastache rugosus, 10 to 20 parts of herba schizonepetae, 10 to 20 parts of radix angelicae, 8 to 12 parts of folium perillae, 8 to 12 parts of cortex magnoliae officinalis, 10 to 20 parts of rhizoma et radix notopterygii, 10 to 20 parts of fructus xanthii and 15 to 30 parts of rhizoma zingiberis recens. The traditional Chinese medicine composition has the beneficial effects that the traditional Chinese medicine composition has a very good curative effect on common cold in children, and also has a very good curative effect on a series of respiratory and digestive system symptoms caused by common cold due to wind-cold; according to the traditional Chinese medicine composition, medicine components are absorbed through skin, the opportunity that medicine enters blood after being absorbed through digestive tracts is reduced, the burden on internal organs of children and the risk of potential side effects are reduced, and the acceptability of the children is high.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating children's colds, and a preparation method and application thereof. Background Art

[0002] Common diseases in children are lung diseases, and common symptoms include fever, runny nose, cough, wheezing, sputum, etc. Common Western medical treatments include medication, nebulization and infusion therapy, and TCM treatments include decoction of Chinese medicine, acupoint application, pediatric massage, etc. However, whether it is Western medicine or Chinese medicine, children's difficulty in taking oral medication is a common problem, which is mainly manifested in the following aspects: 1. Taste sensitivity: Children's taste buds are more sensitive than adults. Many drugs themselves have unpleasant tastes such as bitterness and astringency, which can easily cause children's disgust and resistance. 2. Psychological fear: Children often have a fear of unknown things, including fear of drugs. They may be afraid of the taste of drugs, or have a resistance to drugs because of unpleasant experiences of taking drugs (such as vomiting, choking, etc.). 3. Difficulty in swallowing: Infants and preschoolers may have difficulty swallowing tablets or capsules, and drugs with bad smells because their swallowing function has not yet fully developed. 4. Poor self-control ability: Children's self-control ability and understanding are relatively weak, and they cannot understand the importance of taking medicine like adults, so it is difficult for them to cooperate to complete the medication process. 5. Single drug form: Although there are syrups and granules designed for children with good taste on the market, not all drugs have dosage forms suitable for children, which also increases the difficulty of children taking medicine. Most of the drugs for children's nebulized treatment are hormone treatments, which are not effective for children with recurrent respiratory tract infections. Due to the low degree of cooperation and poor compliance of pediatric massage, some parents are unable to insist on multiple massage treatments a day. Acupoint patch treatment cannot be widely carried out because the drug directly contacts the skin for irritation. Some children have delicate skin and are prone to allergies to Chinese medicine powder / acupuncture patch tape.

[0003] Therefore, seeking a safe, convenient, effective and highly tolerated treatment method for children is an urgent need in the current field of pediatric TCM treatment. Summary of the invention

[0004] The present application provides a Chinese medicine composition for treating colds in children, and a preparation method and application thereof, aiming to solve the problem of difficulty in taking oral medicines for treating colds in children.

[0005] In a first aspect of the present application, a traditional Chinese medicine composition for treating colds in children is provided, comprising the following raw materials in parts by weight: 10-20 parts of Patchouli, 10-20 parts of Schizonepeta, 10-20 parts of Angelica dahurica, 8-12 parts of Perilla leaves, 8-12 parts of Magnolia officinalis, 10-20 parts of Notopterygium wilfordii, 10-20 parts of Xanthium sibiricum, and 15-30 parts of ginger.

[0006] Patchouli is pungent and slightly warm in nature, and enters the spleen, stomach, and lung meridians. It has the effect of aromatically removing dampness and relieving heat. The combination of Perilla leaf and Patchouli is especially effective for children's colds: damp-heat at the beginning, which damages the lungs and spleen. As stated in "Compendium of Materia Medica": Patchouli is aromatic but not too strong, warm but not too dry, can remove dampness and evil, and help the spleen and stomach to be healthy. It is the quickest medicine for dampness that stagnates spleen yang, fatigue and weakness, loss of appetite, and dirty tongue coating.

[0007] Schizonepeta is pungent and slightly warm in nature. It enters the lung and liver meridians and can release wind and regulate blood. Its aroma is light and lifts, and it specifically flows through the skin. It is pungent but not strong, warm but not dry, and can relieve wind evil on the skin surface, regardless of cold or heat.

[0008] Angelica dahurica has the effects of curing diseases and removing dampness, draining pus and promoting tissue regeneration, promoting blood circulation and relieving pain. It is often used to treat symptoms such as colds, headaches, rhinitis, toothache, etc.

[0009] Perilla leaves are pungent and warm in nature, and enter the lung and spleen meridians. They can dispel cold, relax the stomach and promote qi circulation. Moreover, the purple color of perilla leaves can enter the blood, dissipate the skin and fur externally, relax the chest and diaphragm internally, and relieve depression and promote qi circulation. As stated in "Compendium of Materia Medica": "Perilla has a strong aromatic smell... It can open the skin and fur externally, release lung qi and open the pores. It can relieve nasal congestion and clear the head and eyes, and is a magical medicine for wind-cold external infection; it can open the chest and diaphragm, wake up the spleen and stomach, dissipate phlegm and fluid, relieve depression and promote qi stagnation.

[0010] Magnolia officinalis is bitter, pungent and warm in nature. It enters the spleen meridian, stomach meridian and large intestine meridian. It has the effects of warming the middle, lowering qi, drying dampness and eliminating phlegm. Adding Magnolia officinalis to the prescription can harmonize the Ying and Wei, and effectively clear the symptoms of stomach and viscera disharmony caused by the transmission of wind and cold.

[0011] Qianghuo is bitter and pungent, with a mild and warm Qi. It enters the bladder meridian and kidney meridian, and is also said to enter the liver meridian. Qianghuo is good at dispersing wind evil, relieving pain in the joints of the whole body, eliminating new and old rheumatism, and stopping headaches and toothaches. The ancients said that Qianghuo is the king medicine because it can set things right and has the power of rotation. Qianghuo is pungent and has a rising Qi, but its nature is too dispersing. It can be used to guide the meridians, to reach up and down, so that the wind will go away and the dampness will disappear.

[0012] Xanthium sibiricum, bitter, sweet, pungent; warm in nature; slightly toxic. It is mainly used to treat headaches caused by wind and cold, sinusitis, toothache, wind and cold dampness, cramps and pain in the limbs, scabies, and itching. "Compendium of Materia Medica" says: It is good at inducing sweating, dispersing rheumatism, passing through the top of the brain, going down to the feet and knees, and reaching the skin. It treats headaches, blurred vision, toothache, and sinusitis.

[0013] Ginger is pungent and slightly warm. It enters the lung meridian, spleen meridian, and stomach meridian. It can release the exterior, dispel cold, stop vomiting, and relieve phlegm. Ginger enters the five internal organs, removes phlegm and lowers qi, stops vomiting, and eliminates rheumatism, cold and heat; ginger can also benefit the spleen and stomach and dispel wind and cold. The combination of these medicines can dispel wind and relieve exterior symptoms, promote lung function and clear the orifices, and harmonize the effects of Ying and Wei.

[0014] According to some embodiments of the Chinese medicine composition described in the present application, the following raw materials are included in weight parts: 12-18 parts of Patchouli, 12-18 parts of Schizonepeta, 12-18 parts of Angelica dahurica, 9-11 parts of Perilla leaves, 9-11 parts of Magnolia officinalis, 12-18 parts of Notopterygium wilfordii, 12-18 parts of Xanthium sibiricum, and 18-25 parts of ginger.

[0015] According to some embodiments of the Chinese medicine composition described in the present application, the following raw materials are included in weight parts: 15 parts of Patchouli, 15 parts of Schizonepeta, 15 parts of Angelica dahurica, 10 parts of Perilla leaves, 10 parts of Magnolia officinalis, 15 parts of Notopterygium wilfordii, 15 parts of Xanthium sibiricum, and 20 parts of ginger.

[0016] The second aspect of the present application provides a method for preparing the Chinese medicine composition according to the first aspect of the present application, comprising the following steps:

[0017] Patchouli, Nepeta, Angelica dahurica, Perilla leaf, Magnolia officinalis, Notopterygium wilfordii, Xanthium sibiricum, ginger and water are mixed for decoction and filtered to obtain the traditional Chinese medicine composition.

[0018] According to some embodiments of the preparation method described in the present application, the weight ratio of the total weight of the Patchouli, Schizonepeta, Angelica dahurica, Perilla frutescens, Magnolia officinalis, Notopterygium wilfordii, Xanthium sibiricum and ginger to water is 1: (40-60).

[0019] According to some embodiments of the preparation method described in the present application, the decocting temperature is 90-100° C., and the decocting time is 10-30 min.

[0020] The third aspect of the present application provides a use of the Chinese medicine composition described in the first aspect of the present application or the Chinese medicine composition obtained by the preparation method described in the second aspect of the present application in treating children's colds.

[0021] According to some embodiments of the application described in the present application, a pediatric patient suffering from a cold is given a medicinal bath using an aqueous solution containing the Chinese medicine composition.

[0022] The herbal ingredients in the Chinese medicine bath can penetrate through the skin, and the warmth directly stimulates the whole body of the child. Traditional Chinese medicine believes that human veins are channels for the circulation of qi and blood, which are spread all over the body, connecting the internal organs and external collaterals. The medicinal bath is a Chinese medicine that acts directly on the body through the skin and acupuncture points, thereby regulating yin and yang and unblocking the meridians. When yin and yang are balanced and the meridians are unblocked, all diseases will disappear.

[0023] According to some embodiments of the application described in the present application, the weight ratio of the traditional Chinese medicine composition to water in the aqueous solution is 1: (40-60).

[0024] According to some embodiments of the application described in the present application, the duration of the medicinal bath is 10-20 minutes.

[0025] Children's internal organs are delicate, their physical form and qi are not full, their pores are sparse, and their defense function is weak. They are easily invaded by external pathogens and become ill. Because children's constitution is characterized by "immature yin and immature yang", they are very sensitive to drugs. When treating children's diseases, we should make full use of the "light, clear and clever" characteristics of children's medication to provide personalized treatment for children. Chinese medicine bathing is the embodiment of "light, clear and clever" treatment. The pores are the tiny gaps between the skin, muscles and internal organs, and are also the gateway for external pathogens to invade. Chinese medicine external washing can reduce the potential side effects of drugs directly entering the body, and at the same time better help drugs penetrate into the children's bodies through the pores. It is especially suitable for some cases where oral medications are not suitable or long-term maintenance treatment is required and there is a concern about the cumulative toxicity of drugs.

[0026] The beneficial effects of this application include:

[0027] 1. The Chinese medicine composition described in the present application has a good therapeutic effect on children's colds, and also has a good therapeutic effect on a series of respiratory and digestive system symptoms caused by colds.

[0028] 2. The Chinese medicine composition described in the present application absorbs drug ingredients through the skin, which reduces the chance of drugs being absorbed into the blood through the digestive tract, reduces the burden on children's internal organs and the risk of potential side effects, and is relatively acceptable to children. DETAILED DESCRIPTION

[0029] In the present invention, the terms "one embodiment", "some embodiments", "examples", "specific examples", or "some examples" etc. mean that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the described specific features, structures, materials or characteristics may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, without contradiction.

[0030] Example 1

[0031] A Chinese medicine composition for treating colds in children, comprising the following raw materials in parts by weight: 15g of Patchouli, 15g of Schizonepeta, 15g of Angelica Dahurica, 10g of Perilla Leaf, 10g of Magnolia Bark, 15g of Notopterygium, 15g of Xanthium sibiricum, and 20g of ginger;

[0032] The method for preparing the Chinese medicine composition for treating colds in children comprises the following steps:

[0033] Mix Patchouli, Nepeta, Angelica dahurica, Perilla leaf, Magnolia bark, Notopterygium incisum, Xanthium sibiricum, ginger and water, wherein the weight ratio of the total weight of Patchouli, Nepeta, Angelica dahurica, Perilla leaf, Magnolia bark, Notopterygium incisum, Xanthium sibiricum and ginger to the weight ratio of water is 1:50, and boil the mixture at 100°C for 20 minutes, filter and obtain the Chinese medicine composition (liquid medicine).

[0034] Example 2

[0035] A Chinese medicine composition for treating colds in children, comprising the following raw materials in parts by weight: 10g of Patchouli, 10g of Schizonepeta, 10g of Angelica Dahurica, 8g of Perilla Leaf, 8g of Magnolia Bark, 10g of Notopterygium, 10g of Xanthium sibiricum, and 15g of ginger;

[0036] The method for preparing the Chinese medicine composition for treating colds in children comprises the following steps:

[0037] Mix Patchouli, Nepeta, Angelica dahurica, Perilla leaf, Magnolia bark, Notopterygium incisum, Xanthium sibiricum, ginger and water, wherein the weight ratio of the total weight of Patchouli, Nepeta, Angelica dahurica, Perilla leaf, Magnolia bark, Notopterygium incisum, Xanthium sibiricum and ginger to the weight ratio of water is 1:50, and boil the mixture at 100°C for 20 minutes, filter and obtain the Chinese medicine composition (liquid medicine).

[0038] Example 3

[0039] A Chinese medicine composition for treating colds in children, comprising the following raw materials in parts by weight: 18g of Patchouli, 15g of Schizonepeta, 10g of Angelica Dahurica, 9g of Perilla Leaf, 9g of Magnolia Bark, 12g of Notopterygium, 12g of Xanthium sibiricum, and 18g of ginger;

[0040] The method for preparing the Chinese medicine composition for treating colds in children comprises the following steps:

[0041] Mix Patchouli, Nepeta, Angelica dahurica, Perilla leaf, Magnolia bark, Notopterygium incisum, Xanthium sibiricum, ginger and water, wherein the weight ratio of the total weight of Patchouli, Nepeta, Angelica dahurica, Perilla leaf, Magnolia bark, Notopterygium incisum, Xanthium sibiricum and ginger to the weight ratio of water is 1:50, and boil the mixture at 100°C for 20 minutes, filter and obtain the Chinese medicine composition (liquid medicine).

[0042] Example 4

[0043] A Chinese medicine composition for treating colds in children, comprising the following raw materials in parts by weight: 20g of Patchouli, 20g of Schizonepeta, 20g of Angelica Dahurica, 12g of Perilla Leaf, 12g of Magnolia Bark, 20g of Notopterygium, 20g of Xanthium sibiricum, and 15g of ginger;

[0044] The method for preparing the Chinese medicine composition for treating colds in children comprises the following steps:

[0045] Mix Patchouli, Nepeta, Angelica dahurica, Perilla leaf, Magnolia bark, Notopterygium incisum, Xanthium sibiricum, ginger and water, wherein the weight ratio of the total weight of Patchouli, Nepeta, Angelica dahurica, Perilla leaf, Magnolia bark, Notopterygium incisum, Xanthium sibiricum and ginger to the weight ratio of water is 1:50, and boil the mixture at 100°C for 20 minutes, filter and obtain the Chinese medicine composition (liquid medicine).

[0046] Comparative Example 1

[0047] The only difference between Comparative Example 1 and Example 1 is that the Chinese medicine composition described in Comparative Example 1 does not contain the raw material ginger.

[0048] Comparative Example 2

[0049] The only difference between Comparative Example 2 and Example 1 is that the Chinese medicine composition described in Comparative Example 2 does not contain the raw material Perilla leaf.

[0050] Comparative Example 3

[0051] The only difference between Comparative Example 3 and Example 1 is that the Chinese medicine composition described in Comparative Example 3 does not contain the raw material Xanthium sibiricum.

[0052] Comparative Example 4

[0053] The only difference between Comparative Example 4 and Example 1 is that the Chinese medicine composition described in Comparative Example 4 does not contain the raw materials Magnolia officinalis and Notopterygium wilfordii.

[0054] Comparative Example 5

[0055] The only difference between Comparative Example 5 and Example 1 is that the Chinese medicine composition described in Comparative Example 5 does not contain the raw materials Patchouli and Schizonepeta.

[0056] Efficacy study of the Chinese medicine composition described in this application:

[0057] Study subjects: 60 children aged 0-3 years with cold;

[0058] Research method: The Chinese medicine compositions described in Example 1 and Comparative Examples 1-5 were mixed with water respectively, with the weight ratio of the Chinese medicine composition to water being 1:50. The water temperature was adjusted to 100°C. When the temperature was suitable, 5L of aqueous solution of the Chinese medicine composition was added to each child, and the child was placed in the water containing the Chinese medicine composition for a 15-minute medicinal bath. The bath was continued for 3 consecutive days, once a day, and the efficacy was observed after 3 days.

[0059] After 3 days, it was found that the fever, runny nose, cough and sputum symptoms of the 10 children with colds who took the Chinese medicine composition described in Example 1 of the present application for bathing were improved, while the cold symptoms of the children who took the Chinese medicine composition described in Comparative Examples 1-5 for bathing were alleviated, but mild cold symptoms still existed.

[0060] Although the above embodiments have been shown and described, it is to be understood that the above embodiments are exemplary and are not to be construed as limitations on the present invention. Changes, modifications, substitutions and variations of the above embodiments by those of ordinary skill in the art are all within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating colds in children, characterized in that: The invention comprises the following raw materials in parts by weight: 10-20 parts of Patchouli, 10-20 parts of Schizonepeta, 10-20 parts of Angelica dahurica, 8-12 parts of Perilla leaves, 8-12 parts of Magnolia officinalis, 10-20 parts of Notopterygium wilfordii, 10-20 parts of Xanthium sibiricum and 15-30 parts of ginger.

2. The Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 12-18 parts of Patchouli, 12-18 parts of Schizonepeta, 12-18 parts of Angelica dahurica, 9-11 parts of Perilla leaves, 9-11 parts of Magnolia officinalis, 12-18 parts of Notopterygium wilfordii, 12-18 parts of Xanthium sibiricum and 18-25 parts of ginger.

3. The Chinese medicine composition according to claim 1, characterized in that The invention comprises the following raw materials in parts by weight: 15 parts of Patchouli, 15 parts of Schizonepeta, 15 parts of Angelica dahurica, 10 parts of Perilla leaves, 10 parts of Magnolia officinalis, 15 parts of Notopterygium wilfordii, 15 parts of Xanthium sibiricum fruits and 20 parts of ginger.

4. The method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The following steps are involved: Patchouli, Nepeta, Angelica dahurica, Perilla leaf, Magnolia officinalis, Notopterygium wilfordii, Xanthium sibiricum, ginger and water are mixed for decoction and filtering to obtain the traditional Chinese medicine composition.

5. The preparation method according to claim 4, characterized in that: The weight ratio of the total weight of the Patchouli, Nepeta, Angelica Dahurica, Perilla Leaf, Magnolia Bark, Notopterygium, Xanthium sibiricum and ginger to water is 1:(40-60).

6. The preparation method according to claim 4, characterized in that: The decoction temperature is 90-100° C., and the decoction time is 10-30 min.

7. Use of the Chinese medicine composition according to any one of claims 1 to 3 or the Chinese medicine composition obtained by the preparation method according to any one of claims 4 to 6 in treating colds in children.

8. The use according to claim 7, characterized in that: The water solution containing the Chinese medicine composition is used to perform medicinal bathing on children suffering from cold.

9. The use according to claim 8, characterized in that: The weight ratio of the traditional Chinese medicine composition to water in the aqueous solution is 1:(40-60).

10. The use according to claim 8, characterized in that: The duration of the medicinal bath is 10-20 minutes.