Method, system, device and medium for proton arc therapy implementation

Abstract

The invention discloses a method, a system, equipment and a medium for implementing proton arc treatment, and the method comprises the steps: designing a proton arc treatment plan, carrying out proton treatment based on the proton arc treatment plan, and dividing a tumor into a plurality of equal-energy layers in the depth direction in the proton arc treatment process, each energy layer is correspondingly provided with a control point and a plurality of irradiation points; calculating the beam spot delivery time, the beam spot conversion time and the energy layer conversion time corresponding to each control point, and calculating the total dose delivery time of each control point based on the beam spot delivery time, the beam spot conversion time and the energy layer conversion time; and adjusting the total dose delivery time corresponding to each control point by taking the equal total dose delivery time of each control point as a target so as to realize constant-speed rotation of the proton radiotherapy system rack. According to the technical scheme, the dosage throwing rate can be increased while the mechanical burden of the rack can be relieved.

Description

Technical Field

[0001] The present invention belongs to the field of medical physics simulation computing technology, and in particular relates to a method, system, device and medium for implementing proton arc therapy. Background Art

[0002] In recent years, radiotherapy technology, as one of the three major tumor treatment methods, has been developing rapidly. Compared with photon radiotherapy, proton radiotherapy has better target conformity and can better treat deep tumors. Proton arc therapy has attracted much attention due to its ability to continuously output proton beams during gantry rotation. Compared with intensity modulated proton therapy (IMPT), proton arc therapy can significantly reduce damage to organs at risk and has the potential advantage of providing robust plan quality.

[0003] Achieving continuous gantry rotation has been a major obstacle to proton arc therapy delivery technology. Proton gantries typically weigh more than 100 tons, and rapid acceleration or deceleration can cause a lot of wear and tear, placing a heavy burden on mechanical systems such as the gantry motor, circuit breakers, rolling floors, beamline magnets, etc. To avoid any interference, it is ideal to deliver proton arc therapy plans at a constant speed like conventional CBCT acquisition. Different proton arc therapy plans using different optimization frames may result in different irradiation times for each beam, which requires rapid acceleration or deceleration of the gantry speed in order to connect the control points so that the proton arc plan can be rotated out of the book and implemented smoothly. Summary of the invention

[0004] The purpose of the present invention is to provide a method, system, device and medium for implementing proton arc therapy to solve the problems existing in the above-mentioned prior art.

[0005] To achieve the above object, the present invention provides a method for implementing proton arc therapy, comprising:

[0006] designing a proton arc therapy plan based on the target area position of the patient, performing proton therapy based on the proton arc therapy plan, and dividing the tumor into a plurality of equal energy layers along the depth direction during the proton arc therapy, each of the energy layers being correspondingly provided with a control point and a plurality of irradiation points;

[0007] Calculating the beam spot delivery time, beam spot conversion time and energy layer conversion time corresponding to each of the control points, and calculating the total dose delivery time of each of the control points based on the beam spot delivery time, beam spot conversion time and energy layer conversion time;

[0008] With the goal of making the total dose delivery time of each control point equal, the total dose delivery time corresponding to each control point is adjusted to achieve uniform rotation of the proton radiotherapy system frame.

[0009] Optionally, the designing of a proton arc therapy plan based on the target area position of the patient specifically includes:

[0010] A scanning angle is set based on a target area position and an organ at risk position of the patient, and an arc area is determined based on the scanning angle;

[0011] The path tracking method is used to calculate the equivalent water depth thickness on the beam path, and a cluster analysis is performed on the equivalent water depth thickness. Based on the cluster analysis results, the optimal number of arc intervals and the corresponding angle range are determined.

[0012] Based on the optimal number of arc intervals and the corresponding angle range, the arc area is divided into arc intervals to obtain a number of arc intervals; wherein the beam energy corresponding to the initial angle of each arc interval is the energy corresponding to the maximum equivalent water depth thickness of the interval;

[0013] The gantry rotation is controlled based on the divided arc intervals. During the gantry rotation, the beam energy of each control point is reduced successively, so that continuous beam emission is achieved during the entire gantry rotation process and the proton arc therapy plan is completed.

[0014] Optionally, performing proton therapy based on the proton arc therapy plan specifically includes:

[0015] Based on the preset depth dose, a small proton beam is used to cover the target area through magnetic field scanning, and each equal energy layer is scanned and irradiated layer by layer by proton irradiation until each equal energy layer and the corresponding irradiation point are irradiated.

[0016] Optionally, the calculation process of the total dose delivery time of each control point specifically includes:

[0017] During proton arc therapy, when one irradiation point is irradiated by the proton beam, the beam is turned off, the scanning iron current is changed, the beam is moved to the next irradiation point, and irradiation is continued until the preset irradiation point is irradiated by the proton beam; the time for each irradiation point to be irradiated by the proton beam is the beam spot delivery time, the time from turning off the beam to moving the beam to the next irradiation point is the beam spot switching time, and the switching time between energy layers is the energy layer switching time;

[0018] The total dose delivery time of each control point is calculated based on the beam spot delivery time, the beam spot switching time and the energy layer switching time.

[0019] Optionally, the adjusting the total dose delivery time corresponding to each of the control points specifically includes:

[0020] With the goal of making the total dose delivery time of each control point equal, the beam spot delivery time, beam spot switching time and energy layer switching time corresponding to each control point are adjusted;

[0021] The adjustment process includes: adjusting the beam spot delivery time by controlling the beam intensity of the proton beam, adjusting the beam spot switching time by controlling the beam spot scanning speed of the rack, and adjusting the energy layer switching time by controlling the buffer area between adjacent control points.

[0022] A system for delivering proton arc therapy, comprising:

[0023] The delivery plan design module is used to design the proton arc therapy plan according to the patient's target location;

[0024] a dose delivery time calculation module, for performing proton therapy according to the proton arc therapy plan, dividing the tumor into a plurality of equal energy layers along the depth direction during the proton arc therapy, each of the energy layers being provided with a control point and a plurality of irradiation points; calculating the corresponding beam spot delivery time, beam spot conversion time and energy layer conversion time of each of the control points, and calculating the total dose delivery time of each of the control points based on the beam spot delivery time, beam spot conversion time and energy layer conversion time;

[0025] The proton radiotherapy system rack control module is used to adjust the total dose delivery time corresponding to each control point with the goal of making the total dose delivery time of each control point equal, so as to achieve uniform rotation of the proton radiotherapy system rack.

[0026] An electronic device comprises a memory and a processor, wherein the memory is used to store a computer program, and the processor runs the computer program to enable the electronic device to execute a method for implementing proton arc therapy.

[0027] A computer-readable storage medium stores a computer program, wherein the computer program, when executed by a processor, implements the method for implementing proton arc therapy.

[0028] The technical effects of the present invention are:

[0029] The method provided by the present invention can make the frame rotate at a uniform speed, reduce the frequent acceleration and deceleration of the frame weighing more than 100 tons, reduce the mechanical burden of the frame rotation, and extend the service life; after the frame rotates at a uniform speed, the total dose delivery time and the dynamic delivery time calculated according to the dose delivery model are reduced, so the dose delivery efficiency can be improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0031] The drawings constituting a part of the present application are used to provide a further understanding of the present application. The illustrative embodiments and descriptions of the present application are used to explain the present application and do not constitute an improper limitation on the present application. In the drawings:

[0032] Figure 1 This is a flowchart of implementing the uniform rotation of the gantry of the proton radiotherapy system during the proton arc therapy process of the first embodiment of the present invention.

[0033] Figure 2 This is a dose distribution diagram of Example 1 of the present invention.

[0034] Figure 3 This is a dynamic relationship diagram of the original gantry rotation speed, the "on / off" delivery state of the proton beam, the energy increase or decrease, and the gantry cumulative angle obtained in the first embodiment of the present invention.

[0035] Figure 4 This is a dynamic relationship diagram of the gantry rotation speed after beam current adjustment, the "on / off" delivery state of the proton beam, energy increase or decrease, and the gantry cumulative angle obtained in the first embodiment of the present invention.

[0036] Figure 5 This is a dynamic relationship diagram of the gantry rotation speed after adjusting the beam spot scanning speed, the "on / off" delivery state of the proton beam, the energy increase or decrease, and the gantry cumulative angle obtained in Example 1 of the present invention.

[0037] Figure 6 It is a dynamic relationship diagram of the gantry rotation speed, the "on / off" delivery state of the proton beam, the energy increase or decrease and the gantry cumulative angle after the specific buffer area is designed obtained in the first embodiment of the present invention. DETAILED DESCRIPTION

[0038] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0039] It should be understood that the terms described in the present invention are only for describing special embodiments and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. Each smaller range between the intermediate value in any stated value or stated range and any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0040] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to those skilled in the art. The present application description and examples are exemplary only.

[0041] The words “include,” “including,” “have,” “contain,” etc. used in this article are open-ended terms, meaning including but not limited to.

[0042] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present application will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0043] Embodiment 1

[0044] like Figure 1 - Figure 6 As shown, in this embodiment, a method for implementing proton arc therapy is provided, including: designing a proton arc therapy plan based on the target area position of the patient, performing proton therapy based on the point proton arc therapy plan, and during the proton arc therapy, dividing the tumor into a plurality of equal energy layers along the depth direction, each of the energy layers being correspondingly provided with a control point and a plurality of irradiation points; calculating the beam spot delivery time, beam spot conversion time and energy layer conversion time corresponding to each of the control points, and calculating the total dose delivery time of each of the control points based on the beam spot delivery time, beam spot conversion time and energy layer conversion time; with the goal of making the total dose delivery time of each of the control points equal, adjusting the total dose delivery time corresponding to each of the control points to achieve uniform rotation of the proton radiotherapy system frame.

[0045] This embodiment relates to a method for making a proton radiotherapy system gantry rotate at a uniform speed during proton arc therapy, including: step S1: designing a proton arc therapy plan; step S2: calculating time according to a proton radiotherapy system dose delivery mode; step S3: adjusting the beam intensity and beam spot scanning time of each beam and designing a scanning buffer area at each control point; step S4: achieving uniform rotation of the gantry. This embodiment can reduce the mechanical burden of the gantry while improving the dose delivery effect, and has a driving effect on the development of proton arc therapy technology.

[0046] like Figure 1 As shown in the figure, there are three methods to rotate the gantry of the proton radiotherapy system at a constant speed during proton arc therapy, including:

[0047] Step S1: Arrange all beams in the arc region in an arc shape with a fixed gantry angle as an interval, segment the arc region by a clustering method, ensure that the energy of each beam in each sub-region is arranged in descending order, and realize the proton arc therapy delivery plan.

[0048] S1.1. Arc area division. When designing proton arc therapy, the appropriate scanning angle will be set according to the location of the patient's target area and the location of the surrounding organs at risk. During proton arc therapy, the proton radiotherapy system gantry rotates and scans from a specified initial angle to another angle. In the treatment plan before arc division, the gantry will frequently accelerate and decelerate during scanning due to the different beam energies of each control point. The gantry of the proton therapy machine weighs hundreds of tons, and frequent acceleration and deceleration during rotation will cause mechanical wear. Previous studies have found that the gantry can achieve energy reduction conversion in a shorter time during rotation. However, when the arc angle required for treatment is large, it is difficult to achieve energy reduction conversion throughout the entire arc scanning process. Therefore, the arc is divided, and energy reduction conversion can be more easily achieved in the segmented arc area, while avoiding frequent acceleration and deceleration of the gantry. The equivalent water thickness (WET) from the incident point to the distal end of the tumor on the beam path was calculated according to the path tracking method. The WET was clustered and analyzed by the clustering method, and the arc area was divided into arc intervals to determine the optimal number of arc intervals and the angle range included in the corresponding intervals.

[0049] S1.2, energy is arranged in descending order to realize the proton arc therapy delivery plan. The beam energy corresponding to the initial angle of each segmented arc is the energy corresponding to the maximum WET of the segment. The beam energy of each control point in the arc interval decreases in sequence with the rotation direction. The entire plan can realize proton arc therapy delivery while the gantry rotates.

[0050] Step S2: Obtain the corresponding spot switching time (Spot Switch Time, T) according to the different dose delivery modes of the proton radiotherapy system under study. sswt ), Spot Spill Time (T sspt ) and Energy Switch Time (T est ), and the total dose delivery time (Beam Delivery Time, T BDT ).

[0051] S2.1. Proton rotation intensity modulated proton therapy uses a small proton beam to cover the outside of the target area through magnetic field scanning. The depth dose is controlled by using different proton beam energies and range converters. The tumor is divided into different equal energy layers along the depth direction. Each layer is irradiated with protons of the same energy. Each layer has a certain number of irradiation points. Generally, irradiation starts from the deepest layer. When all irradiation points in this layer reach the preset dose, the proton beam energy is changed and the next layer is irradiated. The layers are scanned and irradiated in turn until all equal energy layers and irradiation points are irradiated. In proton arc therapy, each control point corresponds to only one energy layer, and there is no situation where the beam is changed within the control point.

[0052] S2.2, Dose delivery time. During the proton rotation intensity modulated dose delivery process, when one irradiation point is irradiated, the beam is turned off, the scanning iron current is changed, and the beam is moved to the next irradiation point. The irradiation continues until all the planned irradiation points are irradiated. The time spent at the irradiation point is called the spot spill time (T SSPT ), which is determined by the beam intensity; the time required to turn off the beam, change the scanning iron current, and move the beam to the next irradiation point is called the spot switching time (T SSWT ), which is related to the gantry rotation speed; the beam energy of each control point is different, and the switching time between energy layers is recorded as the energy layer switching time (Energy Switch Time, T EST Conventional proton radiotherapy systems can calculate the total dose delivery time (B eam Delivery Time, T ) for each control point based on these time parameters. BDT ), the calculation formula is,

[0053] T BDT =TS SWT +T SSPT +T EST .

[0054] Step S3, (1) T SSPT Depends on the beam intensity; (2) T SSWT Depends on the beam spot scanning speed of the gantry; (3) There is a buffer area between adjacent control points. The T of each control point can be adjusted by adjusting the beam intensity of each beam, the scanning speed of each control point, and by designing a specific buffer area for each control point. BDT equal.

[0055] S3.1, T SSPT Depends on the beam intensity. When a proton therapy plan is completed and dose optimization is performed, the number of protons corresponding to each beam spot is fixed. When delivering the same number of protons, the stronger the beam intensity, the higher the T SSPTThe shorter the beam intensity is, the greater the beam intensity is. SSPT There is an inverse relationship between them.

[0056]

[0057] Where BI represents the beam intensity; T i is the minimum unit (MU) delivery time, and N particle The charge of a single proton.

[0058] S3.2, T SSWT Depends on the beam spot scanning speed of the gantry, proton arc therapy uses a small proton beam to cover the outside of the target area through magnetic field scanning, and the depth dose is controlled by using different proton beam energies and range converters. When the proton beam has covered the target area, its beam spot delivery position is fixed. This embodiment aims to change the gantry beam spot scanning speed between beam spots with the same spacing to shorten T SSWT .

[0059] S3.3. There is a buffer area between adjacent control points. Due to the different beam energies, there is a buffer area for energy layer conversion between adjacent control points. When the gantry scans this area, no beam will be emitted. The scanning angle of each control point is fixed, and a specific buffer area angle size is designed for each control point, which can achieve the T BDT same.

[0060] As shown in formula S2.2, by adjusting the beam intensity of each beam, the scanning speed of each control point, and by designing a specific buffer area for each control point, the T of each control point is BDT equal.

[0061] Step S4: T of each control point BDT This can achieve uniform speed rotation of the proton radiotherapy system gantry.

[0062] The gantry rotation speed is defined as,

[0063]

[0064] θ=θ de +θ buf

[0065] Among them, v represents the gantry rotation speed, θ represents the fixed angle of each control point, and its size can be defined according to the specific situation. θ is the beam area θ de and buffer area θ buf When θ is a fixed value, adjust the T of each control point BDT Equality can achieve uniform speed rotation of the proton radiotherapy system frame.

[0066] Figure 2This is the dose distribution diagram obtained in this embodiment. It can be seen that the dose is evenly distributed in the target area with high conformity, meeting the prescription dose requirements of the target area.

[0067] Figure 3 This is a dynamic relationship diagram of the original gantry rotation speed, the "on / off" delivery state of the proton beam, the energy increase or decrease, and the gantry cumulative angle obtained in the first embodiment. It can be seen that there is an obvious gantry rotation deceleration in each energy increase stage and the gantry rotation speed in the energy decrease stage between beams is inconsistent.

[0068] Figure 4 This is a dynamic relationship diagram of the gantry rotation speed after adjusting the beam current, the "on / off" delivery state of the proton beam, the energy increase or decrease, and the gantry cumulative angle obtained in this embodiment 1. It can be seen that the gantry rotation speed reaches a uniform speed during the dose delivery process.

[0069] Figure 5 This is a dynamic relationship diagram of the gantry rotation speed, the "on / off" delivery state of the proton beam, the energy increase or decrease, and the gantry cumulative angle after adjusting the beam spot scanning speed obtained in this embodiment 1. It can be seen that the gantry rotation speed reaches a uniform speed during the dose delivery process.

[0070] Figure 6 This is a dynamic relationship diagram of the gantry rotation speed, the "on / off" delivery state of the proton beam, the energy increase or decrease, and the gantry cumulative angle obtained in the first embodiment of the present invention after the specific buffer area is designed. It can be seen that the gantry rotation speed reaches a uniform speed during the dose delivery process.

[0071] By comparing the planning quality before and after (1) adjusting the beam, (2) adjusting the beam spot scanning speed, and (3) designing a specific buffer area, the dose distribution of the target area and the organ at risk meets the prescription requirements. In this embodiment, the gantry rotates at a constant speed, which reduces the frequent acceleration and deceleration of the gantry weighing more than 100 tons, reduces the mechanical burden of the gantry rotation, and extends the service life. After the gantry rotates at a constant speed, the total dose delivery time and dynamic dose delivery time calculated according to the dose delivery model are reduced, thereby improving the dose delivery efficiency.

[0072] A system for delivering proton arc therapy, comprising:

[0073] The delivery plan design module is used to design the proton arc therapy plan according to the patient's target location;

[0074] a dose delivery time calculation module, for performing proton therapy according to the proton arc therapy plan, dividing the tumor into a plurality of equal energy layers along the depth direction during the proton arc therapy, each of the energy layers being provided with a control point and a plurality of irradiation points; calculating the corresponding beam spot delivery time, beam spot conversion time and energy layer conversion time of each of the control points, and calculating the total dose delivery time of each of the control points based on the beam spot delivery time, beam spot conversion time and energy layer conversion time;

[0075] The proton radiotherapy system rack control module is used to adjust the total dose delivery time corresponding to each control point with the goal of making the total dose delivery time of each control point equal, so as to achieve uniform rotation of the proton radiotherapy system rack.

[0076] An electronic device comprises a memory and a processor, wherein the memory is used to store a computer program, and the processor runs the computer program to enable the electronic device to execute a method for implementing proton arc therapy.

[0077] A computer-readable storage medium stores a computer program, wherein the computer program, when executed by a processor, implements the method for implementing proton arc therapy.

[0078] The above is only a preferred specific implementation of the present application, but the protection scope of the present application is not limited thereto. Any changes or substitutions that can be easily thought of by a person skilled in the art within the technical scope disclosed in the present application should be included in the protection scope of the present application. Therefore, the protection scope of the present application should be based on the protection scope of the claims.

Claims

1. A method for implementing proton arc therapy, characterized in that: include: designing a proton arc therapy plan based on the target area position of the patient, performing proton therapy based on the proton arc therapy plan, and dividing the tumor into a plurality of equal energy layers along the depth direction during the proton arc therapy, each of the energy layers being correspondingly provided with a control point and a plurality of irradiation points; Calculating the beam spot delivery time, beam spot conversion time and energy layer conversion time corresponding to each of the control points, and calculating the total dose delivery time of each of the control points based on the beam spot delivery time, beam spot conversion time and energy layer conversion time; With the goal of making the total dose delivery time of each control point equal, the total dose delivery time corresponding to each control point is adjusted to achieve uniform rotation of the proton radiotherapy system frame.

2. A method for implementing proton arc therapy according to claim 1, characterized in that: The proton arc therapy plan is designed based on the target area position of the patient, specifically comprising: A scanning angle is set based on a target area position and an organ at risk position of the patient, and an arc area is determined based on the scanning angle; The path tracking method is used to calculate the equivalent water depth thickness on the beam path, and a cluster analysis is performed on the equivalent water depth thickness. Based on the cluster analysis results, the optimal number of arc intervals and the corresponding angle range are determined. Based on the optimal number of arc intervals and the corresponding angle range, the arc area is divided into arc intervals to obtain a number of arc intervals; wherein the beam energy corresponding to the initial angle of each arc interval is the energy corresponding to the maximum equivalent water depth thickness of the interval; The gantry rotation is controlled based on the divided arc intervals. During the gantry rotation, the beam energy of each control point is reduced successively, so that continuous beam emission is achieved during the entire gantry rotation process and the proton arc therapy plan is completed.

3. A method for implementing proton arc therapy according to claim 1, characterized in that: The performing proton therapy based on the proton arc therapy plan specifically includes: Based on the preset depth dose, a small proton beam is used to cover the target area through magnetic field scanning, and each equal energy layer is scanned and irradiated layer by layer by proton irradiation until each equal energy layer and the corresponding irradiation point are irradiated.

4. A method for implementing proton arc therapy according to claim 1, characterized in that: The calculation process of the total dose delivery time of each control point specifically includes: During proton arc therapy, when one irradiation point is irradiated by the proton beam, the beam is turned off, the scanning iron current is changed, the beam is moved to the next irradiation point, and irradiation is continued until the preset irradiation point is irradiated by the proton beam; the time for each irradiation point to be irradiated by the proton beam is the beam spot delivery time, the time from turning off the beam to moving the beam to the next irradiation point is the beam spot switching time, and the switching time between energy layers is the energy layer switching time; The total dose delivery time of each control point is calculated based on the beam spot delivery time, the beam spot switching time and the energy layer switching time.

5. A method for implementing proton arc therapy according to claim 1, characterized in that: The adjusting of the total dosage delivery time corresponding to each of the control points specifically includes: With the goal of making the total dose delivery time of each control point equal, the beam spot delivery time, beam spot switching time and energy layer switching time corresponding to each control point are adjusted; The adjustment process includes: adjusting the beam spot delivery time by controlling the beam intensity of the proton beam, adjusting the beam spot switching time by controlling the beam spot scanning speed of the rack, and adjusting the energy layer switching time by controlling the buffer area between adjacent control points.

6. A system for implementing proton arc therapy, characterized in that: include: The delivery plan design module is used to design the proton arc therapy plan according to the patient's target location; a dose delivery time calculation module, for performing proton therapy according to the proton arc therapy plan, dividing the tumor into a plurality of equal energy layers along the depth direction during the proton arc therapy, each of the energy layers being provided with a control point and a plurality of irradiation points; calculating the corresponding beam spot delivery time, beam spot conversion time and energy layer conversion time of each of the control points, and calculating the total dose delivery time of each of the control points based on the beam spot delivery time, beam spot conversion time and energy layer conversion time; The proton radiotherapy system rack control module is used to adjust the total dose delivery time corresponding to each control point with the goal of making the total dose delivery time of each control point equal, so as to achieve uniform rotation of the proton radiotherapy system rack.

7. An electronic device, characterized in that: The device comprises a memory and a processor, wherein the memory is used to store a computer program, and the processor runs the computer program to enable the electronic device to execute a method for implementing proton arc therapy according to any one of claims 1 to 5.

8. A computer-readable storage medium, characterized in that: A computer program is stored therein, and when the computer program is executed by a processor, a method for implementing proton arc therapy as claimed in any one of claims 1 to 5 is implemented.

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