Method and system for determining ASD related factors of burn patient

Abstract

The invention discloses a method and system for determining related factors of occurrence of ASD of burn patients, and the method comprises the steps: dividing the patients into mild, moderate, severe and extremely severe burns according to burn areas, and recording detailed personal information and other related data, such as gender, age, injury cause and the like; the method comprises the following steps of: performing ASD diagnosis on a burn patient by a psychiatrist according to the fifth edition (Diagnostic and Statistic Management Of Mental Dissorders 5, DSM-5) of 'Mental Diagnostic and Statistic Handbook', performing psychological assessment on the patient by adopting an acute stress disorder scale (ASD-5), and detecting hemodynamic response of a specific brain region by using a near-infrared brain function imaging technology (fNIRS) so as to objectively reflect the change of a brain function state. And finally, systematically determining key factors influencing ASD occurrence through single-factor analysis, two-sample correlation analysis and multi-factor analysis. In addition, the method further comprises evaluation of the life quality of the patient, and the rehabilitation condition and the social function recovery degree of the patient can be comprehensively known. Through early recognition and intervention, the life quality and the rehabilitation effect of the burn patient can be remarkably improved.

Description

Technical Field

[0001] The present invention relates to the field of mental health technology, and in particular to a method for determining the relationship between ASD and burn area. Background Art

[0002] Burns are a common traumatic disease. Patients not only need to face a long treatment process, but also experience severe psychological stress reactions. Acute stress disorder (ASD) is one of the common psychological problems in burn patients, which seriously affects the quality of life and recovery process of patients. ASD usually occurs within 3 days to 1 month after the traumatic event, and is mainly manifested by symptoms such as intrusion, negative mood, separation, avoidance and arousal.

[0003] At present, the main methods for evaluating ASD in burn patients include psychological scale assessment and clinical diagnosis. Commonly used psychological scales include the Acute Stress Disorder Rating Scale (ASD-5), which assess the severity of patients' symptoms through self-assessment or peer assessment. In addition, some studies have also used brain function detection technology, such as functional near-infrared spectroscopy (fNIRS), to assist in the diagnosis of ASD. fNIRS reflects the functional state of the brain by monitoring changes in the concentration of hemoglobin in the cerebral cortex, and has achieved remarkable results in the diagnosis of mental illnesses such as depression, bipolar disorder, and schizophrenia.

[0004] Although existing psychological scales and brain function testing technologies have made some progress in the assessment of ASD, there are still some shortcomings. First, psychological scale assessment relies on patients' self-reports and is easily affected by subjective factors, resulting in low accuracy of the assessment results. Secondly, although existing brain function testing technologies such as fNIRS can provide information on the functional status of the brain, in actual applications, data processing is complex, requiring professional technicians and a long analysis time, making it difficult to be widely used in clinical practice. Finally, the existing assessment methods fail to fully consider the impact of burn area on the occurrence of ASD and cannot provide clinicians with a comprehensive assessment tool. Summary of the invention

[0005] In view of the above defects or improvement needs of the prior art, an object of the present invention is to provide a method for determining the relationship between ASD and burn area.

[0006] According to a first aspect of the present invention, there is provided a method for determining factors associated with the occurrence of ASD in burn patients, comprising:

[0007] S100, selecting multiple burn patients who meet the inclusion criteria, grading them according to the burn area, and recording the burn grade and other relevant information of the patients;

[0008] S200, using near-infrared brain functional imaging technology to detect cerebral hemodynamic activity while the multiple burn patients perform a speech fluency task, and recording the detection data respectively;

[0009] S300, respectively calculating the S integral values ​​of six brain regions of interest, namely, the left Broca's area, the right Broca's area, the left dorsolateral prefrontal lobe, the right dorsolateral prefrontal lobe, the left frontal pole, and the right frontal pole, according to the detection data;

[0010] S400, evaluating and recording the ASD conditions of the multiple burn patients using an acute stress disorder rating scale;

[0011] S500, performing univariate analysis, two-sample correlation analysis and multivariate analysis according to the burn levels of the multiple burn patients, other relevant information, S score values ​​of the six interest areas and the ASD conditions of the multiple burn patients, and determining the relevant factors for the occurrence of ASD in burn patients according to the analysis results.

[0012] Furthermore, step S100 also includes evaluating the quality of life of the burn patient after the illness and recording the quality of life score.

[0013] Furthermore, the burn levels in step S100 include: mild burns, moderate burns, severe burns and extremely severe burns.

[0014] Furthermore, the other relevant information in step S100 includes gender, age, whether it is flame burn, third-degree burn area, ABSI score, post-injury measurement time, whether it is inhalation injury, whether multiple parts of the body are burned, whether married, and quality of life score.

[0015] Further, step S200 includes: recording and displaying a curve of HbO concentration changing with time during the speech fluency task, and the area under the final curve is the measured S integral value.

[0016] Furthermore, the calculation of the S integral value includes:

[0017]

[0018] Wherein, IV represents the S integral value; t represents the time point; and f(t) represents the oxygenated hemoglobin concentration at the time point t.

[0019] Furthermore, the language fluency task includes a 30-second pre-task baseline, a 60-second word formation task, and a 60-second post-task baseline.

[0020] Furthermore, during the 60-second word formation task, the patient needs to form words as much as possible according to the Chinese characters prompted by the voice every 15 seconds, and repeat this four times.

[0021] Furthermore, the S integral value is an indicator for measuring the intensity of cerebral hemodynamic response. By calculating the area under the curve of the change of oxygenated hemoglobin concentration over time during the task period, it reflects the increase in oxygenated hemoglobin concentration during the language fluency task, and further reflects the degree of brain area activation.

[0022] According to a second aspect of the present invention, there is provided a system for determining factors associated with the occurrence of ASD in burn patients, comprising:

[0023] In the first module, multiple burn patients who meet the inclusion criteria are selected, graded according to the burn area, and the burn grade and other relevant information of the patients are recorded;

[0024] The second module is to use near-infrared brain functional imaging technology to detect cerebral hemodynamic activity while the multiple burn patients perform a speech fluency task, and record the detection data respectively;

[0025] The third module calculates the S integral values ​​of six brain regions of interest, namely, the left Broca's area, the right Broca's area, the left dorsolateral prefrontal lobe, the right dorsolateral prefrontal lobe, the left frontal pole, and the right frontal pole, according to the detection data;

[0026] The fourth module is to evaluate and record the ASD conditions of the multiple burn patients through the Acute Stress Disorder Scale;

[0027] The fifth module performs univariate analysis, two-sample correlation analysis and multivariate analysis according to the burn levels of the multiple burn patients, other relevant information, S score values ​​of the six interest areas and the ASD conditions of the multiple burn patients, and determines the relevant factors for the occurrence of ASD in burn patients based on the analysis results.

[0028] Beneficial effects of the present invention:

[0029] 1. This method first divides patients into mild, moderate, severe and extremely severe burns according to the burn area, and records detailed personal information and other relevant data, such as gender, age, cause of injury, etc. Then, the patient is psychologically evaluated using the Acute Stress Disorder Scale (ASD-5), and the hemodynamic response of specific brain areas is detected using near-infrared functional brain imaging technology (fNIRS) to objectively reflect changes in brain functional state. Finally, the key factors affecting the occurrence of ASD are systematically determined through univariate analysis, two-sample correlation analysis and multivariate analysis. By early identification of the risk factors for ASD in burn patients, effective psychological intervention measures can be taken in a timely manner to effectively improve the patient's quality of life and rehabilitation effect, and reduce the occurrence of long-term psychological problems. In addition, this method also includes an assessment of the patient's quality of life, which helps to fully understand the patient's rehabilitation status and the degree of recovery of social functions. Through early identification and intervention, the present invention can significantly improve the quality of life and rehabilitation effect of burn patients.

[0030] Additional aspects and advantages of the present application will be partially given in the following description, which will become apparent from the following description, or will be understood through the practice of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] The above and / or additional aspects and advantages of the present application will become apparent and easily understood from the following description of the embodiments in conjunction with the accompanying drawings, in which:

[0032] Figure 1 It is a flow chart of a method for determining relevant factors of ASD in burn patients according to an embodiment of the present invention. DETAILED DESCRIPTION

[0033] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It is to be understood that the specific embodiments described herein are only used to explain the present invention, rather than to limit the present invention. It should also be noted that, for ease of description, only parts related to the present invention, rather than all structures, are shown in the accompanying drawings.

[0034] Those skilled in the art will appreciate that, unless otherwise stated, the singular forms "a", "an", "said" and "the" used herein may also include plural forms. It should be further understood that the term "comprising" used in the specification of the present application refers to the presence of the features, integers, steps, operations, elements and / or components, but does not exclude the presence or addition of one or more other features, integers, steps, operations, elements, components and / or combinations thereof.

[0035] It will be understood by those skilled in the art that, unless otherwise defined, all terms (including technical terms and scientific terms) used herein have the same meaning as the general understanding of those skilled in the art to which this application belongs. It should also be understood that terms such as those defined in general dictionaries should be understood to have the same meaning as in the context of the prior art, and will not be interpreted with an idealized or overly formal meaning unless specifically defined as in the embodiments of this application.

[0036] The present invention provides a method and system for determining the relevant factors of ASD in burn patients. The method first divides the patients into mild, moderate, severe and extremely severe burns according to the burn area, and records detailed personal information and other relevant data, such as gender, age, cause of injury, etc. Then, the patient is psychologically evaluated by the acute stress disorder scale (ASD-5), and the hemodynamic response of specific brain areas is detected by near-infrared functional brain imaging technology (fNIRS) to objectively reflect the changes in brain functional state. Finally, the key factors affecting the occurrence of ASD are systematically determined by univariate analysis, two-sample correlation analysis and multivariate analysis. By early identification of the risk factors for ASD in burn patients, effective psychological intervention measures can be taken in time to effectively improve the quality of life and rehabilitation effect of patients and reduce the occurrence of long-term psychological problems. In addition, the method also includes an assessment of the quality of life of patients, which helps to fully understand the rehabilitation status and social function recovery degree of patients. Through early identification and intervention, the present invention can significantly improve the quality of life and rehabilitation effect of burn patients.

[0037] Embodiment 1:

[0038] like Figure 1 As shown, an embodiment of the present invention provides a method for determining related factors of ASD in burn patients, comprising:

[0039] S100. Select burn patients who meet the inclusion criteria, grade them according to the burn area, and record the burn grade and other relevant information of the patients;

[0040] S200, evaluating the ASD condition of the burn patient by using a psychometric questionnaire, wherein the patient within one month after the injury is measured by the acute stress disorder scale, and the patient more than one month after the injury is measured by the post-traumatic stress disorder detection scale;

[0041] S300, using near-infrared brain functional imaging technology to detect the patient's brain function, and calculating the S integral values ​​of the six interest areas: left Broca's area, right Broca's area, left dorsolateral area, right dorsolateral area, left frontal pole, and right frontal pole;

[0042] S400, performing univariate analysis, two-sample correlation analysis, and multivariate analysis according to the patient's burn grade, other relevant information, ASD score, and S score values ​​of the six interest areas, and determining the related factors of ASD in burn patients according to the analysis results.

[0043] Embodiment 2:

[0044] The embodiment of the present invention provides a specific experimental method process and results for determining the relevant factors of ASD in burn patients, including:

[0045] S1. Set the inclusion and exclusion criteria for the experimental subjects. The inclusion criteria are: (1) burn patients caused by various causes of injury; (2) aged between 18 and 65 years old; (3) no limit on the total area of ​​burns; (4) able to communicate effectively and cooperate with the relevant tests of this experiment; (5) willing to participate in this experiment after informed consent. The exclusion criteria are: (1) death within 3 days after injury; (2) organic brain disease, especially metal foreign bodies in the skull; (3) history of mental illness; (4) dependence on or abuse of psychoactive substances; (5) currently taking or having taken psychotropic drugs within 2 weeks before the start of this experiment; (6) pregnant or lactating women; (7) those with severe immune or endocrine diseases; (8) lack of necessary clinical data.

[0046] S2. A cross-sectional survey method was used to enroll 121 burn patients who met the inclusion criteria and were admitted to the Burn Department of Wuhan Third Hospital from May to September 2024. There were 87 males (71.9%) and 34 females (28.1%), aged 42 (32, 52) years, with a total burn area of ​​21% (7.5%, 48%) TBSA, and an Abbreviated Burn Severity Index (ABSI) score of 12.5 (4.4, 32). According to the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders, the diagnostic criteria for acute stress disorder (ASD) are 9 or more of the 14 symptoms in the five categories of intrusion, negative mood, dissociation, avoidance, and arousal, which begin or worsen after the traumatic event, last for 3 days to 1 month after the trauma, cause clinically significant distress, or lead to impairment of social, occupational, or other important functions, and cannot be attributed to the physiological effects of a substance (such as drugs or alcohol) or other physical illness, and cannot be explained by "brief psychotic disorder";

[0047] S3. Based on clinical experience and literature reports, this experiment collected the patient's injury time, psychological scale and brain function post-injury measurement time, gender, age, cause of injury, total burn area, third-degree burn area, ABSI score, whether it was inhalation injury, whether there were multiple burns (i.e., 3 or more burn sites), marital status, and whether the patient was admitted to the ICU during the shock period. According to the size of the burn area, the patients were divided into mild burns (<10% TBSA), moderate burns (10-29% TBSA), severe burns (30-49% TBSA) and extremely severe burns (≥50% TBSA).

[0048] S4. The Acute Stress Disorder Scale for DSM-5 (ASD-5) was used to measure patients 3 days to 1 month after injury. The scale has 14 questions, each question is scored from 1 to 5 points, and the total score is 14-70 points. The higher the score, the more severe the patient's symptoms. The test-retest reliability of this scale is 0.94, and the internal consistency is 0.96. The Post-traumatic Stress Disorder Scale for DSM-5 Revised was used to measure patients more than 1 month after injury. The scale has 20 questions, each question is scored from 0 to 4 points, and the total score is 0-80 points. The higher the score, the more severe the patient's symptoms. The test-retest reliability of this scale is 0.84, and the validity is 0.87. All patients were measured with the brief version of the Burn Specific Health Scale (BSHS-B). The scale consists of 40 questions, each question is scored from 0 to 4, and the total score is 0 to 160. The higher the score, the higher the quality of life. The test-retest reliability of the scale is 0.95, and the internal consistency is 0.93.

[0049] S5. Near-infrared functional brain imaging technology (fNIRS) is being widely used as a non-invasive examination technology in the clinical diagnosis and treatment of mental illness. In particular, the VFT paradigm has accumulated a lot of literature in the clinical basic research of mental illness. Studies have found that this technology can assist in the clinical diagnosis of mental illness. At present, it mainly focuses on the neural mechanisms and clinical neurobiological markers of depression, bipolar disorder and schizophrenia. All patients in this experiment underwent brain function testing, using a 53-channel fNIRS device (BS-3000, Zilian Hongkang Technology Co., Ltd., China) to measure the concentration changes of hemoglobin in the prefrontal cortex using near-infrared light of two wavelengths of 690 and 830nm. Each channel consists of a light source detector pair with a distance of 3cm, and is placed according to the 10-20 system (the 9th position photoelectrode is located at fpz). 16 light sources and 16 receivers constitute a total of 53 channels. In order to analyze the characteristics of blood oxygen changes in different interest areas, the frontal lobe and left and right temporal lobes were selected for analysis, and a total of 6 interest areas were divided into left and right Broca's areas (Broca-L and Broca-R), left and right dorsolateral (DLPFC-L and DLPFC-R), left and right frontal poles (FPA-L and FPA-R). This experiment used a verbal fluency task (VFT) to observe the changes in oxygen and hemoglobin (HbO), deoxyhemoglobin and total hemoglobin concentrations in the brain area. Among them, the S integral value is an indicator widely used in VFT-fNIRS research. At present, many literature studies have found that this indicator is an effective neurobiological marker that can assist in the diagnosis and identification of various mental and psychological diseases. The calculation formula of the S integral value is, where t is the time point and is the HbO concentration at the moment. The time range of the integral value calculation is the task period, that is, 0-60s after the start of the task, and only when the HbO concentration at the moment is greater than 0 is it included in the integral calculation. The S integral value is an indicator to measure the intensity of cerebral hemodynamic response. By calculating the area under the curve of HbO concentration changing with time during the task period, it reflects the increase in HbO concentration during the task period, and then reflects the degree of brain area activation. Its sensitivity for diagnosing and identifying mental and psychological diseases is 0.759-0.900, and its specificity is 0.833-0.889.

[0050] S6. Statistical analysis. The fNIRS data of this experiment were processed by Matlab2014b software. Homer2, NIRS_KIT and self-written Matlab scripts were mainly used in the processing process. The S integral values ​​of the interest areas between the groups were statistically analyzed to see if there was significant activation. SPSS22.0 was used for data analysis. The non-normal distribution of the quantitative data was expressed by M (P25, P75). The inter-group comparison was performed by two independent sample Mann-Whitney U test. The count data were expressed as frequency (percentage), and the chi-square test or Fisher's exact probability method was performed. Pearson correlation analysis was used for the correlation analysis of the two samples. Combined with the univariate difference results and clinical significance, the independent variables were included in the multivariate logistic regression analysis of ASD in burn patients. P < 0.05 was considered statistically significant.

[0051] The experimental results are as follows:

[0052] 1. As shown in Table 1, in this experiment, 62 burn patients needed to be judged whether ASD occurred, of which 16 (25.8%) were in the ASD-positive group and 46 (71.2%) were in the ASD-negative group. The burn area of ​​the 62 burn patients ranged from 0.2% to 55.0% TBSA, and the patients were 3-30 days after injury. The ASD-positive group and the ASD-negative group were significantly different in gender (P=0.681), age (P=0.753), whether it was flame burn (P=0.190), burn area (P=0.573), third-degree burn area (P=0.935), ABSI score (P=0.601), measurement time after injury (P=0.100), whether it was inhalation injury (P=1.000), whether it was multiple burns (P=0.378), whether married (P= There were no significant differences in the S scores of Broca-L (P=0.025), DLPFC-L (P=0.004), FPA-L (P=0.025), DLPFC-R (P=0.021), and FPA-R (P=0.016) between the ASD-positive group and the ASD-negative group.

[0053] Table 1

[0054]

[0055] 3. As shown in Table 2, this experiment showed that the ASD score of burn patients had no statistically significant correlation with age (P=0.733) and burn area (P=0.673), but had statistically significant correlation with the S-score values ​​of Broca-L (P=0.039), DLPFC-L (P=0.005), FPA-L (P=0.017), DLPFC-R (P=0.005), and FPA-R (P=0.029). In addition, there was no statistically significant correlation between the burn area and age (0.088), Broca-L (P=0.488), DLPFC-L (P=0.952), FPA-L (P=0.273), Broca-R (P=0.199), DLPFC-R (P=0.744), and FPA-R (P=0.756) of burn patients, and age was negatively correlated with the S score of DLPFC-L (P=0.015), FPA-L (P=0.009), and FPA-R (P=0.030).

[0056] Table 2

[0057]

[0058] Burns not only cause direct short-term damage to soft tissues such as the skin, but also cause indirect long-term damage to various systems and organs throughout the body, especially the impact of burns on the nervous-endocrine-immune system, which causes patients to still have serious physical and psychological distress many years after the burn. Burns should be regarded as a chronic disease. This experiment found that the occurrence of ASD after burns was not significantly related to the burn area, and patients with small-area burns may also develop ASD, suggesting that in clinical practice, regardless of the size of the burn area, ASD screening can be carried out as early as possible when the patient's condition is stable, and intervention can be carried out for patients with obvious ASD symptoms to reduce the patient's psychological pain and the possibility of chronic psychological problems that may result. This result is similar to the findings of previous foreign studies, indicating that burns, as sudden accidental injuries, bring psychological shock to patients, and timely attention should be paid to patients' acute stress reactions in the early stage of hospitalization.

[0059] At present, the diagnosis and identification of emotional problems in burn patients mainly rely on the experience of clinical medical staff and mental and psychological scales, but the actual recognition rate is poor. The brain function detected by fNIRS can use objective data to guide the clinic to understand the patient's condition and improve the diagnosis and recognition rate. This experiment found that the brain function of multiple brain regions in ASD-positive patients was significantly lower than that of ASD-negative patients, which suggests that brain function testing can assist the clinic to detect ASD patients in a timely manner. This experiment shows that the prefrontal brain function of patients with ASD after burns is significantly reduced through objective data of brain function, which provides data support for the clinical attention of burn patients to the psychological state.

[0060] It should be understood that, although the steps in the flowchart of the accompanying drawings are displayed in sequence as indicated by the arrows, these steps are not necessarily executed in sequence in the order indicated by the arrows. Unless otherwise specified herein, there is no strict order restriction on the execution of these steps, and they can be executed in other orders. Moreover, at least a part of the steps in the flowchart of the accompanying drawings may include multiple sub-steps or multiple stages, and these sub-steps or stages are not necessarily executed at the same time, but can be executed at different times, and their execution order is not necessarily sequential, but can be executed in turn or alternately with other steps or at least a part of the sub-steps or stages of other steps.

[0061] The above description is only a partial implementation method of the present application. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present application. These improvements and modifications should also be regarded as the scope of protection of the present application.

Claims

1. A method for determining factors associated with the occurrence of ASD in burn patients, characterized in that: include: S100, selecting multiple burn patients who meet the inclusion criteria, grading them according to the burn area, and recording the burn grade and other relevant information of the patients; S200, using near-infrared brain functional imaging technology to detect cerebral hemodynamic activity while the multiple burn patients perform a speech fluency task, and recording the detection data respectively; S300, respectively calculating the S integral values ​​of six brain regions of interest, namely, the left Broca's area, the right Broca's area, the left dorsolateral prefrontal lobe, the right dorsolateral prefrontal lobe, the left frontal pole, and the right frontal pole, according to the detection data; S400, evaluating and recording the ASD conditions of the multiple burn patients using an acute stress disorder rating scale; S500, performing univariate analysis, two-sample correlation analysis and multivariate analysis according to the burn levels of the multiple burn patients, other relevant information, S score values ​​of the six interest areas and the ASD conditions of the multiple burn patients, and determining the relevant factors for the occurrence of ASD in burn patients according to the analysis results.

2. A method for determining related factors of ASD in burn patients according to claim 1, characterized in that: Step S100 also includes evaluating the quality of life of the burn patient after the illness and recording the quality of life score.

3. A method for determining related factors of ASD in burn patients according to claim 1, characterized in that: The burn levels in step S100 include: mild burn, moderate burn, severe burn and extremely severe burn.

4. A method for determining related factors of ASD in burn patients according to claim 1, characterized in that: The other relevant information in step S100 includes gender, age, whether it is flame burn, third-degree burn area, ABSI score, post-injury measurement time, whether it is inhalation injury, whether multiple parts of the body are burned, whether married, and quality of life score.

5. A method for determining related factors of ASD in burn patients according to claim 1, characterized in that: Step S200 includes: recording and displaying a curve of HbO concentration changing with time during the speech fluency task, and the area under the final curve is the measured S integral value.

6. A method for determining the relevant factors of ASD in burn patients according to claim 5, characterized in that: The calculation of the S integral value includes: Wherein, IV represents the S integral value; t represents the time point; f(t) represents the oxygenated hemoglobin concentration at the time point t.

7. A method for determining related factors of ASD in burn patients according to claim 5, characterized in that: The language fluency task included a 30-second pre-task baseline, a 60-second word formation task, and a 60-second post-task baseline.

8. A method for determining related factors of ASD in burn patients according to claim 7, characterized in that: During the 60-second word formation task, the patient needs to form words as much as possible according to the Chinese characters prompted by the voice every 15 seconds, and repeat this four times.

9. A method for determining relevant factors for ASD in burn patients according to any one of claims 1 to 8, characterized in that: The S integral value is an indicator for measuring the intensity of cerebral hemodynamic response. By calculating the area under the curve of the change of oxygenated hemoglobin concentration over time during the task period, it reflects the increase in oxygenated hemoglobin concentration during the language fluency task, and further reflects the degree of brain area activation.

10. A system for determining factors associated with the occurrence of ASD in burn patients, characterized in that: include: In the first module, multiple burn patients who meet the inclusion criteria are selected, graded according to the burn area, and the burn grade and other relevant information of the patients are recorded; The second module is to use near-infrared brain functional imaging technology to detect cerebral hemodynamic activity while the multiple burn patients perform a speech fluency task, and record the detection data respectively; The third module calculates the S integral values ​​of six brain regions of interest, namely, the left Broca's area, the right Broca's area, the left dorsolateral prefrontal lobe, the right dorsolateral prefrontal lobe, the left frontal pole, and the right frontal pole, according to the detection data; The fourth module is to evaluate and record the ASD conditions of the multiple burn patients through the Acute Stress Disorder Scale; The fifth module performs univariate analysis, two-sample correlation analysis and multivariate analysis according to the burn levels of the multiple burn patients, other relevant information, S score values ​​of the six interest areas and the ASD conditions of the multiple burn patients, and determines the relevant factors for the occurrence of ASD in burn patients based on the analysis results.

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