Uric acid-reducing food composition, tablet candy and preparation method of tablet candy

Abstract

The invention relates to a food uric acid reducing composition. The food uric acid reducing composition comprises main materials and auxiliary materials, the mass ratio of the main material to the auxiliary material is 5: 1; the main material is prepared from the following raw materials in parts by weight: 10 to 15 parts of frankincense powder, 10 to 15 parts of tuna peptide, 50 to 100 parts of freeze-dried mulberry powder, 50 to 100 parts of soy isoflavone, 30 to 50 parts of red yeast rice powder, 10 to 20 parts of turmeric powder, 40 to 80 parts of marine red algae powder and 100 to 200 parts of celery seed powder; the auxiliary materials comprise at least one of the following auxiliary materials: a first auxiliary material which is selected from at least one of chicory powder, poria cocos powder and B vitamins; the second auxiliary material is selected from at least one of radix puerariae powder and lophatherum gracile powder; and the third auxiliary material is selected from at least one of sour cherry powder and licorice powder. According to the food uric acid reducing composition, the uric acid reducing effect is improved through combination of specific raw materials, the taste and taste of the product can be improved through food-borne materials, side effects are reduced, and the food uric acid reducing composition is suitable for being taken for a long time.

Description

Technical Field

[0001] The present invention relates to the technical field of food processing, and in particular to a food uric acid lowering composition, a tablet candy and a preparation method thereof. Background Art

[0002] Clinically, therapeutic drugs for controlling uric acid levels are divided into two categories: drugs that inhibit uric acid production and drugs that promote uric acid excretion. The former is mainly xanthine oxidase inhibitors, such as allopurinol, febuxostat, etc., and the latter inhibits uric acid reabsorption in the kidney, such as uricase, etc., but these drugs have large adverse reactions, such as severe allergic reactions, abnormal liver function, gastrointestinal discomfort, etc. At present, there are few functional foods for lowering uric acid, and most of them are brewed tea bags or some single-function uric acid-lowering products. For example, CN116942742B discloses a uric acid-lowering Chinese medicine composition and a preparation method thereof, and the Chinese medicine composition is made of the following raw materials: Anhua black tea bud tip, flat chrysanthemum Sanqi, Cyclocarya paliurus, Dicentra and tangerine peel, etc. The Chinese medicine composition has a good effect of lowering uric acid and blood sugar, but Cyclocarya paliurus is mainly a bitter substance, and Dicentra is bitter in the mouth, which makes patients with high uric acid stay away from it in terms of taste, and it needs to be brewed with boiling water to drink, which is very inconvenient. For patients with uric acid, they often need to eat this kind of functional food for a long time. If the taste is bad and inconvenient to eat, it will inevitably lead to poor patient compliance. Summary of the invention

[0003] 1. Technical issues to be resolved

[0004] In view of the above-mentioned shortcomings and deficiencies of the prior art, the present invention provides a food-based uric acid-lowering composition and a compressed candy. By providing a food-based uric acid-lowering composition, the uric acid-lowering effect is improved by combining raw materials, and the taste and mouthfeel of the product can be improved by selecting food-based materials to make compressed candies, thereby improving the convenience of consumption and solving the problems of the prior art such as allopurinol and febuxostat having large side effects, poor taste and mouthfeel of tea drinks, and inconvenience in taking.

[0005] (II) Technical solution

[0006] In a first aspect, the present invention provides a food-based uric acid-lowering composition, which comprises a main ingredient and an auxiliary ingredient; the mass ratio of the main ingredient to the auxiliary ingredient is 5:1;

[0007] By weight, the main ingredients are composed of 10-15 parts of frankincense powder, 10-15 parts of tuna peptides, 50-100 parts of freeze-dried mulberry powder, 50-100 parts of soy isoflavones, 30-50 parts of red yeast rice powder, 10-20 parts of turmeric powder, 40-80 parts of marine red algae powder and 100-200 parts of celery seed powder; the auxiliary materials include at least one of the following auxiliary materials:

[0008] The first auxiliary material is selected from at least one of chicory powder, tuckahoe powder and B vitamins;

[0009] The second auxiliary material is selected from at least one of kudzu root powder and bamboo leaf powder;

[0010] The third auxiliary material is selected from at least one of sour cherry powder and licorice powder.

[0011] According to a preferred embodiment of the present invention, the main ingredients are composed of 15 parts of frankincense powder, 15 parts of tuna peptides, 75 parts of freeze-dried mulberry powder, 75 parts of soy isoflavones, 40 parts of red yeast rice powder, 15 parts of turmeric powder, 80 parts of marine red algae powder and 150 parts of celery seed powder; the auxiliary materials are composed of 43 parts of kudzu powder, 30 parts of sour cherry powder and 20 parts of licorice powder.

[0012] According to a preferred embodiment of the present invention, the main ingredients are composed of 10 parts of frankincense powder, 10 parts of tuna peptides, 100 parts of freeze-dried mulberry powder, 100 parts of soy isoflavones, 50 parts of red yeast rice powder, 10 parts of turmeric powder, 70 parts of marine red algae powder and 120 parts of celery seed powder; the auxiliary materials are composed of 30 parts of Poria powder, 10 parts of B vitamins, 20 parts of light bamboo leaf powder and 34 parts of licorice powder.

[0013] According to a preferred embodiment of the present invention, the main ingredients are composed of 15 parts of frankincense powder, 15 parts of tuna peptides, 50 parts of freeze-dried mulberry powder, 50 parts of soy isoflavones, 30 parts of red yeast rice powder, 10 parts of turmeric powder, 60 parts of marine red algae powder and 100 parts of celery seed powder; the auxiliary materials are composed of 32 parts of chicory powder, 12 parts of B vitamins and 22 parts of sour cherry powder.

[0014] According to a preferred embodiment of the present invention, the main ingredients are composed of 15 parts of frankincense powder, 15 parts of tuna peptides, 80 parts of freeze-dried mulberry powder, 80 parts of soy isoflavones, 30 parts of red yeast rice powder, 10 parts of turmeric powder, 80 parts of marine red algae powder and 120 parts of celery seed powder; the auxiliary materials are composed of 26 parts of chicory powder, 20 parts of Poria powder, 10 parts of B vitamins, 10 parts of Pueraria powder and 20 parts of sour cherry powder.

[0015] According to a preferred embodiment of the present invention, the main ingredients are composed of 15 parts of frankincense powder, 15 parts of tuna peptides, 50 parts of freeze-dried mulberry powder, 50 parts of soy isoflavones, 50 parts of red yeast rice powder, 20 parts of turmeric powder, 40 parts of marine red algae powder and 180 parts of celery seed powder; the auxiliary materials are composed of 14 parts of chicory powder, 10 parts of Poria powder, 15 parts of B vitamins, 15 parts of Pueraria powder, 20 parts of light bamboo leaf powder and 10 parts of sour cherry powder.

[0016] In a second aspect, the present invention provides a uric acid-lowering tablet candy, which is made by a tableting process using the uric acid-lowering composition of any of the above embodiments and tableting ingredients.

[0017] Preferably, the tableting ingredients include sodium bicarbonate, sorbitol, microcrystalline cellulose and magnesium stearate; the mass ratio of the uric acid lowering composition to the tableting ingredients is 0.8-1.6:1.

[0018] In a third aspect, the present invention further provides a method for preparing a uric acid-lowering compressed candy, comprising the following steps:

[0019] S1. Weigh the components and ingredients of the food uric acid-lowering composition; wherein the mass ratio of sodium bicarbonate, sorbitol, microcrystalline cellulose and magnesium stearate is 10-20:300-480:40-60:5-10;

[0020] S2, the remaining components except sodium bicarbonate and magnesium stearate are put into a mixer and mixed at a mixing speed of 15-45HZ for 5-10min to obtain a premix; sodium bicarbonate and magnesium stearate are added and mixed again for 5-10min to obtain a total mixture;

[0021] S3, add the total mixture to the tablet press, set the average weight and tableting speed, and tablet at a speed of 15-30r / min. Check the hardness and friability of the plain tablets, and transfer the qualified plain tablets to the next process;

[0022] S4, prepare the coating liquid, and coat the plain tablets in a coating machine. The working parameters of the coating machine are: inlet air temperature 65-75°C, outlet air temperature 40-50°C, compressed air pressure 0.3-0.6Mpa, distance from nozzle to tablet surface 25-30cm, and drum speed 1-5rpm;

[0023] S5. After coating, the coated tablets are sealed and packaged.

[0024] Preferably, in S3, during tableting, the average weight is set to 0.9-1 g, the weight difference is controlled within ±5%, the hardness is 80-160 N, and the tablet weight loss does not exceed 1%.

[0025] (III) Beneficial effects

[0026] The technical effects of the present invention are:

[0027] (1) The present invention provides a food-based uric acid-lowering composition, all of which are derived from natural edible materials, have low side effects, and can also improve the taste and mouthfeel of the product; the compressed candies can greatly improve the convenience of consumption, solve the problems of large side effects of drugs such as allopurinol and febuxostat, inconvenience of taking tea drinks, and poor taste and texture of traditional Chinese medicine, and improve the compliance of patients with high uric acid.

[0028] Compared with uric acid lowering drugs, the present invention has low toxicity and can be taken for a long time. The present invention uses natural food materials to prepare uric acid lowering candies. Compared with Chinese medicine and other pharmaceutical preparations, the production cycle is short, the safety is high, and factory-based mass production can be achieved, which has a good application prospect.

[0029] (2) The uric acid lowering composition of the present invention has frankincense that can activate ABCG2 transporter, increase the excretion of uric acid through the intestinal tract, reduce inflammatory response, and alleviate the symptoms caused by hyperuricemia; tuna peptide has the function of lowering blood uric acid and relieving kidney inflammation, while repairing the intestinal barrier, promoting intestinal absorption, regulating intestinal flora, increasing the production of short-chain fatty acids, and enhancing the body's antioxidant capacity, thereby indirectly supporting kidney function and promoting uric acid excretion; freeze-dried mulberries are rich in resveratrol, which can inhibit intestinal purine absorption; soy isoflavones inhibit the activity of xanthine oxidase (XO), reduce uric acid production, and regulate blood lipids to maintain a healthy uric acid level; red yeast rice metabolite Ankaflavin can competitively bind to the XO active site and inhibit the key enzyme for uric acid production; red yeast rice polysaccharides can promote the proliferation of bifidobacteria and enhance purine decomposition metabolism; red yeast rice Monacolin K helps to lower cholesterol and triglyceride levels; the compound of red yeast rice and apigenin (diuretic) can also significantly promote uric acid excretion, promote the excretion of uric acid in the body, and reduce the burden on the kidneys. Turmeric powder is a powerful anti-inflammatory and antioxidant that helps reduce inflammation caused by high uric acid, supports liver health, and promotes the metabolism of uric acid. Marine red algae powder contains introduced glycosaminoglycans that prevent the deposition of sodium urate microcrystals.

[0030] The main ingredients of the present invention work together to reduce uric acid levels through different pathways: among them, antioxidant ingredients (such as tuna peptides, freeze-dried mulberry powder, and soy isoflavones) help protect cells from free radical damage and maintain physical health; anti-inflammatory ingredients (such as frankincense powder and turmeric powder) reduce inflammatory symptoms associated with high uric acid; diuretic ingredients (such as celery seed powder) increase urine volume and promote uric acid excretion; marine red algae powder inhibits the deposition of sodium urate microcrystals; and lipid metabolism regulating ingredients (such as red yeast rice powder) help maintain normal uric acid metabolism. In summary, the main ingredients work synergistically through multiple mechanisms to effectively reduce uric acid levels in the body and improve complications of high uric acid.

[0031] (3) The present invention further prepares compressed candy with the main ingredients and auxiliary ingredients for reducing uric acid; freeze-dried mulberries, soy isoflavones, red yeast rice and the first auxiliary ingredient mainly strengthen the inhibitory effect of uric acid; frankincense, tuna peptides, red yeast rice, apigenin and the second auxiliary ingredient strengthen uric acid excretion; turmeric powder, frankincense and the third auxiliary ingredient synergistically strengthen the relief effect on joint pain caused by uric acid, reduce the inflammatory response of the joints, and relieve inflammation and pain caused by the deposition of uric acid crystals in the joints. The ingredient sodium bicarbonate used in the preparation of compressed candy can interact with other ingredients such as sorbitol, microcrystalline cellulose, etc. during the tableting process, which helps to improve the physical properties of the final product, such as hardness, stability and dissolution rate. Sodium bicarbonate can help alkalize urine, promote uric acid dissolution, and promote uric acid excretion. The red algae powder can inhibit the deposition of sodium urate microcrystals in the joints, and jointly reduce the risk of gout attacks and kidney stones. DETAILED DESCRIPTION

[0032] In order to better explain the present invention and facilitate understanding, the present invention is described in detail below through specific implementation methods.

[0033] Example 1

[0034] This embodiment provides a method for preparing a candy tablet having a uric acid-lowering function, which comprises:

[0035] (1) Weigh 1.5 kg of frankincense powder, 1.5 kg of tuna peptide, 7.5 kg of freeze-dried mulberry powder, 7.5 kg of soy isoflavones, 4 kg of red yeast rice powder, 1.5 kg of turmeric powder, 8 kg of marine red algae powder and 15 kg of celery seed powder, and mix them evenly to obtain the main ingredient.

[0036] (2) Weigh 4.3 kg of kudzu root powder, 3 kg of sour cherry powder and 2.0 kg of liquorice powder, and mix them evenly to obtain auxiliary materials.

[0037] (3) Weigh 1.7 kg of sodium bicarbonate, 48 kg of sorbitol, 0.9 kg of magnesium stearate, and 4.5 kg of microcrystalline cellulose for use as tableting ingredients.

[0038] (4) The remaining components except magnesium stearate and sodium bicarbonate were added into a mixer and mixed at a mixing speed of 30 Hz for 5 min to obtain a premix; sodium bicarbonate and magnesium stearate were then added and mixed again for 5 min to obtain a total mixture.

[0039] (5) Take the punch, check the integrity of the punch, and install it into the tablet press as required. The installed punch runs at no load for 1 minute. After the equipment is running normally, start adding materials and adjust the average weight. The average weight is 0.900g / tablet. Calculate the weight difference. The weight difference is controlled within ±5%. The tableting speed is 20r / min. Check the hardness and brittleness of the blank tablets. The hardness is 80-160N, and the weight loss of the tablets does not exceed 1%. After the blank tablets are inspected and qualified, they are packed into polyethylene lined bags, sealed, and transferred to the next process.

[0040] (6) Prepare the coating solution and coat the plain tablets in a coating machine. The operating parameters of the coating machine are: air inlet temperature 75°C, air outlet temperature 50°C, compressed air pressure 0.5 MPa, distance from nozzle to tablet surface 30 cm, and drum speed 2 rpm. After coating, the coated tablets are placed in a stainless steel barrel lined with a polyethylene bag, sealed, and then bottled. The weight of the tablets after coating is 0.9 g / tablet, 180 tablets / bottle.

[0041] Example 2

[0042] This embodiment provides a method for preparing candy tablets with uric acid lowering function, which is different from that of embodiment 1 in that the composition of the main material and the auxiliary material are different, as follows:

[0043] (1) Weigh 1.0 kg of frankincense powder, 1.0 kg of tuna peptide, 10.0 kg of freeze-dried mulberry powder, 10.0 kg of soy isoflavones, 5.0 kg of red yeast rice powder, 1.0 kg of turmeric powder, 7.0 kg of marine red algae powder and 12 kg of celery seed powder, and mix them evenly to obtain the main ingredient.

[0044] (2) Weigh 3 kg of kudzu root powder, 1 kg of B vitamins, 2.0 kg of loblolly leaf powder and 3.4 kg of liquorice powder, and mix them evenly to obtain auxiliary materials.

[0045] The remaining steps are exactly the same as those in Example 1.

[0046] Example 3

[0047] This embodiment provides a method for preparing candy tablets with uric acid lowering function, which is different from that of embodiment 1 in that the composition of the main material and the auxiliary material are different, as follows:

[0048] (1) Weigh 1.5 kg of frankincense powder, 1.5 kg of tuna peptide, 5.0 kg of freeze-dried mulberry powder, 5.0 kg of soy isoflavones, 3.0 kg of red yeast rice powder, 1.0 kg of turmeric powder, 6.0 kg of marine red algae powder and 10 kg of celery seed powder, and mix them evenly to obtain the main ingredient.

[0049] (2) Weigh 3.2 kg of chicory powder, 1.2 kg of B vitamins, and 2.2 kg of sour cherry powder, and mix them evenly to obtain an auxiliary material.

[0050] The remaining steps are exactly the same as those in Example 1.

[0051] Example 4

[0052] This embodiment provides a method for preparing candy tablets with uric acid lowering function, which is different from that of embodiment 1 in that the composition of the main material and the auxiliary material are different, as follows:

[0053] (1) Weigh 1.5 kg of frankincense powder, 1.5 kg of tuna peptide, 8.0 kg of freeze-dried mulberry powder, 8.0 kg of soy isoflavones, 3.0 kg of red yeast rice powder, 1.0 kg of turmeric powder, 8.0 kg of marine red algae powder and 12 kg of celery seed powder, mix well to obtain the main ingredient.

[0054] (2) Weigh 2.6 kg of chicory powder, 2.0 kg of Poria powder, 1.0 kg of group B vitamins, 1.0 kg of Pueraria powder and 2.0 kg of sour cherry powder, and mix them evenly to obtain auxiliary materials.

[0055] The remaining steps are exactly the same as those in Example 1.

[0056] Example 5

[0057] This embodiment provides a method for preparing candy tablets with uric acid lowering function, which is different from that of embodiment 1 in that the composition of the main material and the auxiliary material are different, as follows:

[0058] (1) Weigh 1.5 kg of frankincense powder, 1.5 kg of tuna peptide, 5.0 kg of freeze-dried mulberry powder, 5.0 kg of soy isoflavones, 5.0 kg of red yeast rice powder, 2.0 kg of turmeric powder, 4.0 kg of marine red algae powder and 18 kg of celery seed powder, and mix them evenly to obtain the main ingredient.

[0059] (2) Weigh 1.4 kg of chicory powder, 1.0 kg of Poria powder, 1.5 kg of Pueraria powder, 1.5 kg of B vitamins, 2.0 kg of Bamboo leaf powder, and 1.0 kg of sour cherry powder, mix well to obtain auxiliary materials.

[0060] The remaining steps are exactly the same as those in Example 1.

[0061] Example 6

[0062] This embodiment provides a method for preparing candy tablets with uric acid lowering function, which is different from the embodiment 1 in that the composition of the auxiliary materials is different, specifically as follows: 2.3 kg of chicory powder, 2.0 kg of tuckahoe powder, 3 kg of sour cherry powder and 2.0 kg of licorice powder are weighed and mixed evenly to obtain the auxiliary materials. The remaining steps are exactly the same as those in the embodiment 1.

[0063] Example 7

[0064] This embodiment provides a method for preparing candy tablets with uric acid lowering function, which is different from the embodiment 1 in that the composition of the auxiliary materials is different, specifically as follows: 2.3 kg of Poria powder, 1.5 kg of B vitamins, 3.5 kg of Pueraria powder, and 2.0 kg of sour cherry powder are weighed and mixed evenly to obtain the auxiliary materials. The remaining steps are exactly the same as those in the embodiment 1.

[0065] Example 8

[0066] This embodiment provides a method for preparing candy tablets with uric acid lowering function, which is different from the embodiment 1 in that the composition of the auxiliary materials is different, specifically as follows: 4 kg of chicory powder, 1.0 kg of B vitamins, 2.3 kg of kudzu root powder, 1.0 kg of loblolly leaf powder, and 1.0 kg of liquorice powder are weighed and mixed evenly to obtain auxiliary materials. The remaining steps are exactly the same as those in the embodiment 1.

[0067] Example 9

[0068] This embodiment provides a method for preparing candy tablets with uric acid lowering function, which is different from the embodiment 2 in that the composition of the auxiliary materials is different, specifically as follows: 3 kg of Poria powder, 1 kg of B vitamins, 2.0 kg of Bamboo Leaf powder, 2.0 kg of sour cherry powder and 1.4 kg of liquorice powder are weighed and mixed evenly to obtain auxiliary materials. The remaining steps are exactly the same as those in the embodiment 2.

[0069] Example 10

[0070] This embodiment provides a method for preparing candy tablets with uric acid lowering function, which is different from the embodiment 2 in that the composition of the auxiliary materials is different, specifically as follows: 2 kg of chicory powder, 2 kg of B vitamins, 2.0 kg of bamboo leaf powder, 2.0 kg of kudzu root powder and 1.4 kg of liquorice powder are weighed and mixed evenly to obtain auxiliary materials. The remaining steps are exactly the same as those in the embodiment 2.

[0071] Comparative Examples 1-4

[0072] Comparative Examples 1-4 correspond to the auxiliary material components in Examples 1 and 6-8, respectively, and do not contain the main material component. The remaining steps are the same as in Example 1.

[0073] Comparative Examples 5-7

[0074] Comparative Examples 5-7 correspond to the auxiliary material components of Examples 2 and 9-10 respectively, and do not contain the main material component. The remaining steps are the same as Example 2.

[0075] Comparative Example 8

[0076] This comparative example is based on Example 1, but the proportion of auxiliary materials is increased, and the mass ratio of auxiliary materials to main materials is 2:5. The remaining steps are exactly the same as those in Example 1.

[0077] Comparative Example 9

[0078] This comparative example is based on Example 1, but the proportion of the main material is increased, and the mass ratio of the main material to the auxiliary material is 7:1. The remaining steps are exactly the same as those in Example 1.

[0079] The compressed candies prepared in the above examples were subjected to zebrafish experiments and Jin Zhengjun Q value method to evaluate the uric acid-lowering efficacy of the compressed candies prepared in the examples and comparative examples. The experimental principles and methods are as follows:

[0080] 1. Detection principle

[0081] In the biochemical chain of uric acid formation, xanthine oxidoreductase catalyzes the last two steps of the reaction, metabolizing hypoxanthine into xanthine, and further decomposing xanthine into the final product uric acid. Uric acid oxidase exists in zebrafish and most mammals, which can effectively reduce uric acid levels, decompose uric acid into highly water-soluble allantoin, and excrete it with urine. To establish a zebrafish hyperuricemia model, it is necessary to add potassium oxonate to inhibit the activity of uric acid oxidase, and at the same time increase the precursor xanthine of uric acid formation to increase the synthesis of uric acid. After testing with a uric acid detector, the uric acid value of zebrafish with hyperuricemia will be significantly higher than that of normal zebrafish. Zebrafish with a 100% increase in uric acid levels are screened out as a hyperuricemia model.

[0082] 2. Testing system and sample size

[0083] Experimental system: wild AB strain zebrafish; zebrafish age: 5 days after fertilization; experimental sample size per group: 30 per well, 3 wells per group, modeling method see the above point 1. The tested zebrafish were divided into two groups, a model control group and a sample group. The sample groups were respectively the mixture of the main ingredients and auxiliary ingredients in the above embodiments or only referred to the auxiliary ingredients of the comparative examples.

[0084] 3. Experimental methods

[0085] (1) Accurately weigh 1 g of each mixture of the main material and the auxiliary material (for a control sample without the main material, only the auxiliary material is weighed) and prepare three gradient aqueous solutions of 0.2 / 1 / 10 mg / mL using deionized water.

[0086] (2) Zebrafish were placed in the prepared three concentration solutions and cultured. After 24 hours of exposure, the mortality rate was less than 10% as the safety threshold. Preliminary experiments determined that the exposure concentration was ≤0.2 mg / mL.

[0087] (3) Model control group: The zebrafish with high uric acid model were treated under normal feeding conditions for 10 days. After the treatment, the ratio of the difference in uric acid levels before and after treatment to the uric acid levels before and after treatment was taken as X. 1 .

[0088] Sample group: The zebrafish were exposed to a certain concentration of sample (≤0.2 mg / mL) for 10 days. During this period, the zebrafish were fed normally in the same way as the model control group, except that a certain concentration of the test sample was added to the feeding solution. After the treatment, the ratio of the difference in uric acid levels before and after treatment to the uric acid levels before and after treatment was X. 2 .

[0089] (4) Uric acid inhibition rate of each sample group = (X 2 -X 1 )×100%;

[0090] In the model control group and the sample group, the uric acid levels of zebrafish before and after treatment were calculated based on the average uric acid levels of three zebrafish randomly picked from each well.

[0091] 4. Data processing methods

[0092] SPSS26 software was used for analysis, GraphPad Prism8 was used for drawing, and data statistics were expressed as mean ± standard deviation. SPSS software was used for normal distribution test of experimental results. If the data conformed to normal distribution, T parameter test or analysis of variance (ANOVA) was used for significance. If it did not conform to normal distribution, non-parametric test was used (result P < 0.05 indicated statistically significant difference)

[0093] 5. Judgment basis

[0094] On the basis of the test meeting the validity, the uric acid value of the model control group increased significantly compared with the blank control group (P < 0.05), which means that the modeling was successful. The uric acid value of the sample test group decreased significantly (P < 0.05), indicating that the sample has the effect of lowering uric acid.

[0095] The Q values ​​of Examples 1, 6-8 and Comparative Examples 1-4 were calculated using the Jinzheng-average Q value method, and the Jinzheng-average Q was calculated according to the following formula:

[0096]

[0097] Where Ea+b is the uric acid inhibition rate when drug A and drug B are used in combination, Ea and Eb are the uric acid inhibition rates when drug A (main ingredient) and drug B (auxiliary ingredient) are used alone. Q < 0.85 is antagonistic, 0.85 ≤ Q ≤ 1.15 is additive, and Q ≥ 1.15 is synergistic.

[0098] 6. The Q value results of uric acid lowering effects of Examples 1, 6-8 and Comparative Examples 1-4 are as follows:

[0099] Table 1:

[0100]

[0101]

[0102] According to the same method as above, the Q values ​​of the uric acid lowering effects of Comparative Examples 5-7 and Examples 2, 9-10 were calculated as follows:

[0103] Table 2:

[0104] Group Exposure concentration Uric acid inhibition rate (%) Kim Jung-kyun Q value The main material of embodiment 2 0.1mg / mL 33％ —— Comparative Example 5 0.02mg / mL 5％ —— Example 2 0.12mg / mL 44％ 1.21 Comparative Example 6 0.02mg / mL 9.00％ —— Example 9 0.12mg / mL 55％ 1.41 Comparative Example 7 0.02mg / mL 7.00％ —— Example 10 0.12mg / mL 46％ 1.22

[0105] The above results show that the combined use of the main ingredient and the auxiliary ingredient in Examples 1, 6-8 and Examples 2, 9-10 can well exert the synergistic effect of the two components and effectively improve the uric acid-lowering effect of the composition.

[0106] Further, according to the above test method and calculation formula, the inhibition rate of the main ingredient and auxiliary ingredient combination in Test Examples 1-5 and Comparative Examples 8-9 on the zebrafish hyperuricemia model is as follows:

[0107] Table 3:

[0108]

[0109]

[0110] It can be seen that the compositions of Examples 1-5 have good uric acid-lowering function for zebrafish with high uric acid at extremely low exposure concentrations. However, after changing the ratio of the main ingredients and auxiliary ingredients in Comparative Examples 8 and 9, the uric acid inhibition rate of the compositions decreased significantly, and the synergistic uric acid-lowering effect was not obvious.

[0111] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that the technical solutions described in the above embodiments may still be modified, or some or all of the technical features therein may be replaced by equivalents. These modifications or replacements, or the technical features in the above embodiments may be combined in the manner described in the embodiments if they do not conflict with each other, and these modifications, replacements or combinations do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A food composition for lowering uric acid, characterized in that: It includes main materials and auxiliary materials; the mass ratio of the main materials to the auxiliary materials is 5:1; By weight, the main ingredients are composed of 10-15 parts of frankincense powder, 10-15 parts of tuna peptides, 50-100 parts of freeze-dried mulberry powder, 50-100 parts of soy isoflavones, 30-50 parts of red yeast rice powder, 10-20 parts of turmeric powder, 40-80 parts of marine red algae powder and 100-200 parts of celery seed powder; the auxiliary materials include at least one of the following auxiliary materials: The first auxiliary material is selected from at least one of chicory powder, tuckahoe powder and B vitamins; The second auxiliary material is selected from at least one of kudzu root powder and bamboo leaf powder; The third auxiliary material is selected from at least one of sour cherry powder and licorice powder.

2. The food composition for lowering uric acid according to claim 1, characterized in that: The main ingredients are composed of 15 parts of frankincense powder, 15 parts of tuna peptides, 75 parts of freeze-dried mulberry powder, 75 parts of soy isoflavones, 40 parts of red yeast rice powder, 15 parts of turmeric powder, 80 parts of marine red algae powder and 150 parts of celery seed powder; the auxiliary materials are composed of 43 parts of kudzu root powder, 30 parts of sour cherry powder and 20 parts of licorice powder.

3. The food composition for lowering uric acid according to claim 1, characterized in that: The main ingredients are composed of 10 parts of frankincense powder, 10 parts of tuna peptides, 100 parts of freeze-dried mulberry powder, 100 parts of soy isoflavones, 50 parts of red yeast rice powder, 10 parts of turmeric powder, 70 parts of marine red algae powder and 120 parts of celery seed powder; the auxiliary materials are composed of 30 parts of tuckahoe powder, 10 parts of B vitamins, 20 parts of loblolly powder and 34 parts of licorice powder.

4. The food composition for lowering uric acid according to claim 1, characterized in that: The main ingredients are composed of 15 parts of frankincense powder, 15 parts of tuna peptides, 50 parts of freeze-dried mulberry powder, 50 parts of soy isoflavones, 30 parts of red yeast rice powder, 10 parts of turmeric powder, 60 parts of marine red algae powder and 100 parts of celery seed powder; the auxiliary materials are composed of 32 parts of chicory powder, 12 parts of B vitamins and 22 parts of sour cherry powder.

5. The food composition for lowering uric acid according to claim 1, characterized in that: The main ingredients are composed of 15 parts of frankincense powder, 15 parts of tuna peptides, 80 parts of freeze-dried mulberry powder, 80 parts of soy isoflavones, 30 parts of red yeast rice powder, 10 parts of turmeric powder, 80 parts of marine red algae powder and 120 parts of celery seed powder; the auxiliary materials are composed of 26 parts of chicory powder, 20 parts of tuckahoe powder, 10 parts of B vitamins, 10 parts of kudzu powder and 20 parts of sour cherry powder.

6. The food composition for lowering uric acid according to claim 1, characterized in that: The main ingredients are composed of 15 parts of frankincense powder, 15 parts of tuna peptides, 50 parts of freeze-dried mulberry powder, 50 parts of soy isoflavones, 50 parts of red yeast rice powder, 20 parts of turmeric powder, 40 parts of marine red algae powder and 180 parts of celery seed powder; the auxiliary materials are composed of 14 parts of chicory powder, 10 parts of poria powder, 15 parts of B vitamins, 15 parts of kudzu root powder, 20 parts of light bamboo leaf powder and 10 parts of sour cherry powder.

7. A compressed candy for lowering uric acid, characterized in that: The food uric acid lowering composition according to any one of claims 1 to 6 is used and tableting ingredients are used to prepare the composition through a tableting process.

8. The uric acid-lowering tablet candy according to claim 7, characterized in that: The tableting ingredients include sodium bicarbonate, sorbitol, microcrystalline cellulose and magnesium stearate; the mass ratio of the uric acid lowering composition to the tableting ingredients is 0.8-1.6:

1.

9. A method for preparing a compressed candy for lowering uric acid, characterized in that: The steps include: S1. Weigh the components and ingredients of the food uric acid-lowering composition; wherein the mass ratio of sodium bicarbonate, sorbitol, microcrystalline cellulose and magnesium stearate is 10-20:300-480:40-60:5-10; S2, the remaining components except sodium bicarbonate and magnesium stearate are put into a mixer and mixed at a mixing speed of 15-45HZ for 5-10min to obtain a premix; sodium bicarbonate and magnesium stearate are added and mixed again for 5-10min to obtain a total mixture; S3, add the total mixture to the tablet press, set the average weight and tableting speed, and tablet at a speed of 15-30r / min. Check the hardness and friability of the plain tablets, and transfer the qualified plain tablets to the next process; S4, prepare the coating liquid, and coat the plain tablets in a coating machine. The working parameters of the coating machine are: inlet air temperature 65-75°C, outlet air temperature 40-50°C, compressed air pressure 0.3-0.6Mpa, distance from nozzle to tablet surface 25-30cm, and drum speed 1-5rpm; S5. After coating, the coated tablets are sealed and packaged.

10. The preparation method according to claim 9, characterized in that: In S3, during tableting, the average weight is set to 0.9-1 g, the weight difference is controlled within ±5%, the hardness is 80-160 N, and the tablet weight loss does not exceed 1%.

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