Mutton sheep anti-stress transition feed and preparation method thereof

Abstract

The invention provides an anti-stress transition feed for mutton sheep and a preparation method of the anti-stress transition feed, and belongs to the field of animal feeds. The transition feed disclosed by the invention is prepared from the following components in parts by weight: 150 parts of basic ration, 0.01 to 0.1 part of geniposide, 0.01 to 0.1 part of baicalin, 0.1 to 2 parts of South African drunken eggplant extract, 0.1 to 3 parts of gamma-aminobutyric acid, 0.1 to 3 parts of 5-hydroxytryptophan, 0.1 to 0.5 part of beta-glucan, 0.1 to 1 part of compound electrolyte, 0.1 to 2 parts of compound probiotics and 0.01 to 0.5 part of xylo-oligosaccharide, and effective components are protected through a triple coating process. The prepared transition feed can obviously reduce the stress behavior of the mutton sheep, and the physiological problems caused by the stress of the mutton sheep are relieved by reducing cortisol and improving the immunity and the content of intestinal probiotics; in addition, the slow release effect is achieved through triple coating, the slow release effect continuously plays a role in the transportation process, the problem that food is not eaten due to stress is solved, and the weight gain rate is obviously increased.

Description

Technical Field

[0001] The invention relates to the technical field of animal feed, in particular to an anti-stress transition feed for mutton sheep and a preparation method thereof. Background Art

[0002] With the intensive and commercial development trend of cattle and sheep farming, the transportation of sheep flocks has become more and more frequent. However, after long-distance transportation, the sheep flocks need to start living in a completely new environment, and this process is often accompanied by the emergence of a series of stress reactions. When the stress is excessive, that is, when the animal body is subjected to long-term or high-intensity stressor stimulation, it will have a serious adverse effect on the body, thereby endangering the health of the animal. After the above stress occurs, it is often manifested as a significant decrease in feed intake, followed by a decrease in egg production rate and slow growth, resulting in a decrease in livestock and poultry production performance and resistance. If there are pathogenic microorganisms in the environment, diseases will occur and mortality will increase.

[0003] At present, in order to prevent and relieve the stress response of sheep, the commonly used method is to solve it through pre-administered medication and the use of anti-stress drugs. However, with the cumulative use of chemical drugs and the implementation of the anti-antibiotic policy, the use of antibiotics and chemical drugs has been strictly restricted. Therefore, in order to achieve the goals of anti-stress, digestion, growth promotion, immunity enhancement, disease reduction, and relief of various stresses, especially cold and heat stress and various colds and coughs caused by long-distance transportation, it is particularly important to find safer and more effective alternatives. Summary of the invention

[0004] The purpose of the present invention is to provide an anti-stress transition feed for mutton sheep and a preparation method thereof. The transition feed prepared by the present invention can significantly reduce the stress behavior of mutton sheep, has a sustained-release effect and continuously exerts its effect during transportation, overcomes the problem of not eating due to stress, and significantly improves the weight gain rate of mutton sheep.

[0005] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0006] In a first aspect, the present invention provides a transitional feed for sheep to resist stress, comprising the following components in parts by weight:

[0007] 150 portions of basic diet, 0.01-0.1 portions of gardenia glycoside, 0.01-0.1 portions of baicalin, 0.1-2 portions of ashwagandha extract, 0.1-3 portions of γ-aminobutyric acid, 0.1-3 portions of 5-hydroxytryptophan, 0.1-0.5 portions of β-glucan, 0.1-1 portions of complex electrolytes, 0.1-2 portions of complex probiotics, and 0.01-0.5 portions of xylo-oligosaccharides.

[0008] Preferably, the basic diet comprises the following raw materials in parts by weight: 80 parts of corn, 30 parts of soybean meal, 20 parts of rapeseed cake and beet meal, and 10 parts of alfalfa pellets.

[0009] Preferably, the composite electrolyte includes potassium ions and magnesium ions.

[0010] Preferably, the composite probiotics include one or more of Lactobacillus plantarum, Lactobacillus reuteri, and Bacillus coagulans;

[0011] The viable bacteria count of the transition feed is 1×10 8 ~5×10 9 CFU / kg.

[0012] The present invention found that mutton stress refers to a series of non-specific adaptive reactions in the body and mind of mutton sheep when they are subjected to adverse external stimuli (such as environmental changes, management operations, diseases, etc.). Among them, there are three aspects: 1. Changes in hormone levels: increased secretion of cortisol (stress hormone) and increased adrenaline. 2. Immunosuppression: decreased lymphocytes, decreased antibody levels, a large number of intestinal probiotics apoptosis, and susceptibility to infection. 3. Metabolic abnormalities: increased blood sugar, electrolyte imbalance (such as hypokalemia), and accelerated muscle decomposition.

[0013] The invention uses gardenia glycoside to enhance gamma-aminobutyric acid (GABA) neurotransmission to indirectly inhibit excessive activation of the HPA axis; baicalin activates mitochondrial fatty acid β-oxidation rate-limiting enzyme CPT1A to accelerate fatty acid degradation and improve energy metabolism abnormalities, thereby reducing elevated cortisol caused by metabolic stress; and the ashwagandha extract reduces the secretion of corticotropin-releasing hormone (CRH), thereby reducing the secretion of adrenocorticotropic hormone (ACTH) by the anterior pituitary, and ultimately reducing the synthesis of adrenal cortisol.

[0014] The gamma-aminobutyric acid in the present invention passes through the blood-brain barrier, antagonizes adrenaline receptors, and inhibits excessive excitement of sympathetic nerves; the 5-hydroxytryptophan therein has a conversion efficiency 3 times higher than that of tryptophan, and quickly relieves anxiety behavior; the beta-glucan therein can activate TLR-2 receptors, promote the secretion of IL-2 and IFN-γ, reverse the Th1 / Th2 imbalance caused by stress, and enhance immunity; the compound probiotics therein can make up for the loss of intestinal probiotics after stress.

[0015] In a second aspect, the present invention provides a method for preparing the above-mentioned transition feed, comprising the following steps:

[0016] S1. Weigh the raw materials according to the weight parts;

[0017] S2. dissolving gardenia glycoside, baicalin, ashwagandha extract, γ-aminobutyric acid, 5-hydroxytryptophan, β-glucan, and compound probiotics in distilled water to obtain a mixed solution;

[0018] S3. The mixed solution, resistant starch and hydroxypropyl methylcellulose are uniformly mixed and spray-dried to obtain first particles;

[0019] S4. mixing the first particles with the sodium alginate solution and then ionically crosslinking and curing to obtain second particles;

[0020] S5. The second particles are coated with ethyl cellulose to obtain third particles;

[0021] S6. Evenly mix the third pellet with the basic diet, complex electrolytes and xylooligosaccharide to obtain a transition feed.

[0022] Preferably, the concentration of the mixed liquid in S2 is 70-90wt%.

[0023] Preferably, the mass ratio of the mixed solution, resistant starch and hydroxypropyl methylcellulose in S3 is 3:7:0.5.

[0024] Preferably, the mass volume ratio of the first particles to the sodium alginate solution in S4 is 1 g: (5-10) mL;

[0025] Preferably, the method of ionic crosslinking and curing in S4 is: transferring the particles to a 5% calcium chloride solution, adjusting the pH to 5.0, and stirring for crosslinking for 30 minutes.

[0026] Preferably, the sodium alginate solution has a concentration of 2 wt %.

[0027] Preferably, the particle size of the third particles in S6 is 40-80 μm.

[0028] The present invention has found that animals usually do not eat during transportation or transfer, and the amount and frequency of food intake are reduced in adverse environments. Therefore, it is necessary to feed transition feed before or after transportation. Traditional transition feed does not have sustained release properties. The present invention prevents the effective substances from losing their activity by wrapping resistant starch, sodium alginate, and ethyl cellulose from the inside out, allowing the active substances to reach the intestine for absorption, and can slowly release the effective substances to achieve the effect of the entire transportation process. The ethyl cellulose layer can withstand the rumen environment and ensure that the active ingredients pass through the rumen intact; the sodium alginate layer pH triggers partial release, taking into account protection and responsiveness; the resistant starch core can be targeted for degradation by intestinal microorganisms to completely release the active substances.

[0029] Compared with the prior art, the present invention has the following beneficial effects:

[0030] The transition feed prepared by the present invention can significantly reduce the stress behavior of mutton sheep, and alleviate the physiological problems caused by stress of mutton sheep by reducing cortisol and improving immunity and intestinal probiotic content; and the sustained release effect is achieved through triple coating, which continuously plays a role during transportation, thus overcoming the problem of not eating due to stress and significantly improving the weight gain rate. DETAILED DESCRIPTION

[0031] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0032] It should be understood that the terms described in the present invention are only for describing special embodiments and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. Each smaller range between the intermediate value in any stated value or stated range and any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0033] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0034] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to those skilled in the art. The present application description and examples are exemplary only.

[0035] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0036] The "room temperature" and "normal temperature" mentioned in the present invention are all calculated as 25±2°C unless otherwise specified.

[0037] The raw materials used in the following examples of the present invention are all commercially available.

[0038] Example 1

[0039] This embodiment provides a mutton sheep anti-stress transition feed, and the preparation method is as follows:

[0040] S1. Weigh the raw material components by weight:

[0041] 150 portions of basal diet, 0.05 portions of gardenia glycoside, 0.05 portions of baicalin, 0.8 portions of ashwagandha extract, 0.8 portions of γ-aminobutyric acid, 0.8 portions of 5-hydroxytryptophan, 0.3 portions of β-glucan, 0.3 portions of complex electrolytes, 1 portion of complex probiotics, and 0.3 portions of xylooligosaccharides; the basal diet includes 80 portions of corn, 30 portions of soybean meal, 20 portions of rapeseed cake and beet meal, and 10 portions of alfalfa pellets; the ratio of complex electrolyte potassium ions and magnesium ions is 1:1; the complex probiotics are Lactobacillus plantarum, Lactobacillus reuteri, and Bacillus coagulans mixed in a ratio of 1:1:1.

[0042] S2. Dissolve gardenia glycoside, baicalin, ashwagandha extract, γ-aminobutyric acid, 5-hydroxytryptophan, β-glucan, and composite probiotics in distilled water to obtain a mixed solution of 80 wt %;

[0043] S3. The mixed solution, resistant starch and hydroxypropyl methylcellulose were uniformly mixed in a mass ratio of 3:7:0.5 and then spray-dried to obtain first particles;

[0044] S4. After mixing the first particles with a 2 wt % sodium alginate solution at 1 g:8 mL, the particles were transferred to a 5 % calcium chloride solution and the pH was adjusted to 5.0, and stirred for cross-linking for 30 minutes to obtain a second particle;

[0045] S5. The second granules are subjected to fluidized bed coating treatment using ethyl cellulose to obtain third granules having a particle size of 40-80 μm;

[0046] S6. The third pellet was mixed evenly with the basic diet, compound electrolytes, and xylooligosaccharides to obtain a transition feed. The final viable bacterial count was 3.26×10 9 CFU / kg.

[0047] Example 2

[0048] This embodiment provides a mutton sheep anti-stress transition feed, and the preparation method is as follows:

[0049] S1. Weigh the raw material components by weight:

[0050] 150 parts of basic diet, 0.1 parts of gardenia glycoside, 0.1 parts of baicalin, 2 parts of ashwagandha extract, 3 parts of γ-aminobutyric acid, 3 parts of 5-hydroxytryptophan, 0.5 parts of β-glucan, 1 part of complex electrolytes, 2 parts of complex probiotics, and 0.5 parts of xylooligosaccharide; the basic diet includes 80 parts of corn, 30 parts of soybean meal, 20 parts of rapeseed cake and beet meal, and 10 parts of alfalfa pellets; the ratio of complex electrolyte potassium ion and magnesium ion is 1:1; the complex probiotics are Lactobacillus plantarum, Lactobacillus reuteri, and Bacillus coagulans mixed in a ratio of 1:1:1.

[0051] S2. Dissolve gardenia glycoside, baicalin, ashwagandha extract, γ-aminobutyric acid, 5-hydroxytryptophan, β-glucan, and composite probiotics in distilled water to obtain a 90 wt % mixed solution;

[0052] S3. The mixed solution, resistant starch and hydroxypropyl methylcellulose were uniformly mixed in a mass ratio of 3:7:0.5 and then spray-dried to obtain first particles;

[0053] S4. After mixing the first particles with a 2 wt % sodium alginate solution at 1 g:10 mL, the particles were transferred to a 5 % calcium chloride solution and the pH was adjusted to 5.0, and stirred for cross-linking for 30 minutes to obtain a second particle;

[0054] S5. The second granules were subjected to fluidized bed coating treatment using ethyl cellulose to obtain third granules having a particle size of 80 μm;

[0055] S6. The third pellet was mixed evenly with the basic diet, compound electrolytes, and xylooligosaccharides to obtain a transition feed. The final viable bacterial count was 4.87×10 9 CFU / kg.

[0056] Example 3

[0057] This embodiment provides a mutton sheep anti-stress transition feed, and the preparation method is as follows:

[0058] S1. Weigh the raw material components by weight:

[0059] 150 portions of basal diet, 0.01 portions of gardenia glycoside, 0.01 portions of baicalin, 0.1 portions of ashwagandha extract, 0.1 portions of γ-aminobutyric acid, 0.1 portions of 5-hydroxytryptophan, 0.1 portions of β-glucan, 0.1 portions of complex electrolytes, 0.1 portions of complex probiotics, and 0.01 portions of xylooligosaccharides; the basal diet includes 80 portions of corn, 30 portions of soybean meal, 20 portions of rapeseed cake and beet meal, and 10 portions of alfalfa pellets; the ratio of complex electrolyte potassium ions and magnesium ions is 1:1; the complex probiotics are Lactobacillus plantarum, Lactobacillus reuteri, and Bacillus coagulans mixed in a ratio of 1:1:1.

[0060] S2. Dissolve gardenia glycoside, baicalin, ashwagandha extract, γ-aminobutyric acid, 5-hydroxytryptophan, β-glucan, and composite probiotics in distilled water to obtain a 70 wt % mixed solution;

[0061] S3. The mixed solution, resistant starch and hydroxypropyl methylcellulose were uniformly mixed in a mass ratio of 3:7:0.5 and then spray-dried to obtain first particles;

[0062] S4. After mixing the first particles with a 2 wt % sodium alginate solution at 1 g:5 mL, the particles were transferred to a 5 % calcium chloride solution and the pH was adjusted to 5.0, and stirred for cross-linking for 30 minutes to obtain a second particle;

[0063] S5. The second granules are subjected to fluidized bed coating treatment using ethyl cellulose to obtain third granules having a particle size of 40-80 μm;

[0064] S6. The third pellet was mixed evenly with the basic diet, compound electrolytes, and xylooligosaccharides to obtain a transition feed. The final viable bacterial count was 1.28×10 9 CFU / kg.

[0065] Comparative Example 1 This comparative example is prepared in the same manner as Example 1, except that it does not contain the ashwagandha extract, but contains 0.4.5 parts of gardenia glycoside and 0.45 parts of baicalin.

[0066] Comparative Example 2 The preparation method of this comparative example is the same as that of Example 1, except that it does not contain gardenia glycoside and baicalin, and the amount of South African somnifera extract is 0.9 parts.

[0067] Comparative Example 3

[0068] The preparation method of this comparative example is the same as that of Example 1, except that it does not contain gardenia glycoside, baicalin, or ashwagandha extract.

[0069] Comparative Example 4

[0070] The preparation method of this comparative example is the same as that of Example 1, except that γ-aminobutyric acid, 5-hydroxytryptophan and β-glucan are not contained.

[0071] Comparative Example 5

[0072] S1. Weigh the raw material components by weight:

[0073] 150 portions of basal diet, 0.05 portions of gardenia glycoside, 0.05 portions of baicalin, 0.8 portions of ashwagandha extract, 0.8 portions of γ-aminobutyric acid, 0.8 portions of 5-hydroxytryptophan, 0.3 portions of β-glucan, 0.3 portions of complex electrolytes, 1 portion of complex probiotics, and 0.3 portions of xylooligosaccharides; the basal diet includes 80 portions of corn, 30 portions of soybean meal, 20 portions of rapeseed cake and beet meal, and 10 portions of alfalfa pellets; the ratio of complex electrolyte potassium ions and magnesium ions is 1:1; the complex probiotics are Lactobacillus plantarum, Lactobacillus reuteri, and Bacillus coagulans mixed in a ratio of 1:1:1.

[0074] S2. Mix all the raw materials evenly to obtain feed.

[0075] Comparative Example 6

[0076] S1. Weigh the raw material components by weight:

[0077] 150 portions of basal diet, 0.05 portions of gardenia glycoside, 0.05 portions of baicalin, 0.8 portions of ashwagandha extract, 0.8 portions of γ-aminobutyric acid, 0.8 portions of 5-hydroxytryptophan, 0.3 portions of β-glucan, 0.3 portions of complex electrolytes, 1 portion of complex probiotics, and 0.3 portions of xylooligosaccharides; the basal diet includes 80 portions of corn, 30 portions of soybean meal, 20 portions of rapeseed cake and beet meal, and 10 portions of alfalfa pellets; the ratio of complex electrolyte potassium ions and magnesium ions is 1:1; the complex probiotics are Lactobacillus plantarum, Lactobacillus reuteri, and Bacillus coagulans mixed in a ratio of 1:1:1.

[0078] S2. Dissolve gardenia glycoside, baicalin, ashwagandha extract, γ-aminobutyric acid, 5-hydroxytryptophan, β-glucan, and composite probiotics in distilled water to obtain a mixed solution of 80 wt %;

[0079] S3. The mixed solution, resistant starch and hydroxypropyl methylcellulose were uniformly mixed in a mass ratio of 3:7:0.5 and then spray-dried to obtain first particles;

[0080] The first pellet is evenly mixed with the basic diet, complex electrolytes and xylooligosaccharide to obtain a transition feed.

[0081] Comparative Example 7

[0082] S1. Weigh the raw material components by weight:

[0083] 150 portions of basal diet, 0.05 portions of gardenia glycoside, 0.05 portions of baicalin, 0.8 portions of ashwagandha extract, 0.8 portions of γ-aminobutyric acid, 0.8 portions of 5-hydroxytryptophan, 0.3 portions of β-glucan, 0.3 portions of complex electrolytes, 1 portion of complex probiotics, and 0.3 portions of xylooligosaccharides; the basal diet includes 80 portions of corn, 30 portions of soybean meal, 20 portions of rapeseed cake and beet meal, and 10 portions of alfalfa pellets; the ratio of complex electrolyte potassium ions and magnesium ions is 1:1; the complex probiotics are Lactobacillus plantarum, Lactobacillus reuteri, and Bacillus coagulans mixed in a ratio of 1:1:1.

[0084] S2. Dissolve gardenia glycoside, baicalin, ashwagandha extract, γ-aminobutyric acid, 5-hydroxytryptophan, β-glucan, and composite probiotics in distilled water to obtain a mixed solution of 80 wt %;

[0085] S3. The mixed solution, resistant starch and hydroxypropyl methylcellulose were uniformly mixed in a mass ratio of 3:7:0.5 and then spray-dried to obtain first particles;

[0086] S4. The first particles are subjected to fluidized bed coating treatment using ethyl cellulose to obtain second particles having a particle size of 40-80 μm;

[0087] S5. Evenly mix the second pellet with the basic diet, complex electrolytes and xylooligosaccharide to obtain a transition feed.

[0088] Experimental Example 1

[0089] 1. Gastric release assay

[0090] The final particles obtained in Examples 1-3 of the present invention and Comparative Examples 6-7 were resuspended with 1 mL of sterile physiological saline, respectively added into 9 mL of artificial gastric juice with pH = 1.5, placed in a 37°C water bath shaker for shaking culture, and the release rates were detected at 1 h, 3 h, and 6 h, respectively, as shown in Table 1.

[0091] Table 1

[0092]

[0093] 2. Intestinal Release Assay

[0094] The final granules obtained in Examples 1-3 of the present invention and Comparative Examples 6-7 were respectively added into artificial intestinal fluid and shaken at 37° C., and then the release rates were tested. See Table 2.

[0095] Table 2

[0096]

[0097]

[0098] It can be seen from Table 1-2 that the particles obtained in Examples 1-3 of the present invention are partially released at the beginning in the stomach, and can be regularly and slowly released after reaching the intestines, achieving a sustained release effect; while Comparative Example 6 is released too quickly in the stomach, resulting in loss of efficacy; and Comparative Example 7 is released quickly in the intestines, resulting in insufficient sustained release.

[0099] Experimental Example 2

[0100] A group of lambs weighing 15-20 kg were first divided into groups (20 in each group) and fed (ad libitum) with the feeds of Examples 1-3 and Comparative Examples 1-7 for 3 days, then transported to another site for 12 hours and continued to be fed for 20 days to calculate the weight gain, and then raised with normal feed until the late fattening period to calculate the weight gain, see Table 3.

[0101] Table 3

[0102]

[0103] It can be seen from Table 3 that the feed prepared in the embodiment of the present invention has an obvious weight gain effect on lambs transported over long distances, and it can be seen that their stress behavior can be reduced; Comparative Examples 1-4 show that the additives gardenia glycoside, baicalin, South African somnifera extract, γ-aminobutyric acid, 5-hydroxytryptophan, and β-glucan have obvious anti-stress effects; Comparative Examples 4-7 show that coating technology is particularly important for the role of additives.

[0104] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A transitional feed for sheep to resist stress, characterized in that: The composition comprises the following components in parts by weight: 150 portions of basic diet, 0.01-0.1 portions of gardenia glycoside, 0.01-0.1 portions of baicalin, 0.1-2 portions of ashwagandha extract, 0.1-3 portions of γ-aminobutyric acid, 0.1-3 portions of 5-hydroxytryptophan, 0.1-0.5 portions of β-glucan, 0.1-1 portions of complex electrolytes, 0.1-2 portions of complex probiotics, and 0.01-0.5 portions of xylo-oligosaccharides.

2. The transition feed according to claim 1, characterized in that: The basic diet includes the following raw materials in parts by weight: 90 parts of corn, 30 parts of soybean meal, 20 parts of rapeseed cake and beet meal, and 10 parts of alfalfa pellets.

3. The transition feed according to claim 1 or 2, characterized in that: The composite electrolyte includes potassium ions and magnesium ions.

4. The transition feed according to claim 1 or 2, characterized in that: The composite probiotics include one or more of Lactobacillus plantarum, Lactobacillus reuteri, and Bacillus coagulans; The viable bacteria count of the transition feed is 1×10 8 ~5×10 9 CFU / kg.

5. The method for preparing the transition feed according to claim 1, characterized in that: The following steps are involved: S1. Weigh the raw materials according to the weight parts; S2. dissolving gardenia glycoside, baicalin, ashwagandha extract, γ-aminobutyric acid, 5-hydroxytryptophan, β-glucan, and compound probiotics in distilled water to obtain a mixed solution; S3. The mixed solution, resistant starch and hydroxypropyl methylcellulose are uniformly mixed and spray-dried to obtain first particles; S4. mixing the first particles with the sodium alginate solution and then ionically crosslinking and curing to obtain second particles; S5. The second particles are coated with ethyl cellulose to obtain third particles; S6. Evenly mix the third pellet with the basic diet, complex electrolytes and xylooligosaccharide to obtain a transition feed.

6. The preparation method according to claim 5, characterized in that: The concentration of the mixed solution in S2 is 70-90 wt %.

7. The preparation method according to claim 5, characterized in that: The mass ratio of the mixed solution, resistant starch and hydroxypropyl methylcellulose in S3 is 3:7:0.

5.

8. The preparation method according to claim 5, characterized in that: The mass volume ratio of the first particles to the sodium alginate solution in S4 is 1 g: (5-10) mL.

9. The preparation method according to claim 8, characterized in that: The sodium alginate solution has a weight percent of 2 wt %.

10. The preparation method according to claim 5, characterized in that: The particle size of the third particles in S6 is 40-80 μm.

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