Glabridin essence and preparation process thereof

Abstract

The glabridin essence is prepared from the following raw materials in percentage by weight: 85%-92% of water, 2%-4% of methylpropanediol, 1%-3% of butanediol, 1%-3% of nicotinamide, 1.0%-2.1% of glabridin, 0.2%-0.6% of raspberry ketone glucoside, 0.3%-0.5% of p-hydroxyacetophenone, 0.3%-0.5% of 1, 3-butanediol, 0.3%-0.5% of 1, 3-butanediol and the balance of deionized water. The ink is prepared from the following components in percentage by weight: 0.3 to 0.6 percent of 1, 2-hexanediol, 0.2 to 0.5 percent of nux prinsepiae crystal, 0.2 to 0.4 percent of annoine, 0.1 to 0.3 percent of Turmeric Gel gum and 0.13 to 0.18 percent of acrylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer. The glabridin and various plant extracts are added into the essence, the process is simple and convenient, the produced essence is very stable, easy to absorb and good in moisturizing and whitening effect, generation of melanin can be effectively hindered, the essence not only plays a role of a daily skin care tonic, but also can protect skin, and it is worthy of noting that the essence is a skin care product with the highest concentration, and the skin care effect is good. The dosage of the glabridin has a certain standard, and the problems of low solubility, poor transdermal permeability, single effect and the like in the traditional application of the glabridin are solved through the synergistic effect of high-purity extraction, targeted delivery and composite active ingredients.

Description

Technical Field

[0001] The invention relates to the technical field of essence liquids, in particular to a glabridin essence liquid and a preparation process thereof. Background Art

[0002] Glabridin is one of the main flavonoid components in Glycyrrhiza glabra. It shows a strong anti-free radical oxidation effect in the cytochrome P450 / NADPH oxidation system, which can significantly inhibit the free radicals produced in the metabolism process in the body, so as to prevent the oxidation-sensitive biomacromolecules and cell walls from being damaged by free radical oxidation. It can prevent and treat certain pathological changes related to free radical oxidation, such as atherosclerosis and cell aging. In the classification of cosmetics, essence generally refers to products with a high concentration of active ingredients. During use, it can enhance the special purpose of care due to the high proportion of active ingredients, so that the skin can achieve a more obvious skin care effect.

[0003] For example, Chinese patent 202011505225.4 proposes a highly effective whitening essence with glabridin as the main ingredient and a preparation method thereof. It contains a variety of plant extracts, the preparation process is simple and convenient, and easy to control. The produced essence is very stable and easy to absorb, moisturize, and has good whitening effects. The use of this invention can effectively hinder the production of melanin, not only plays the role of daily skin care supplements, but also can protect the skin. It is worth noting that essence is the highest concentration of skin care products, and the dosage must have certain standards.

[0004] It can be seen that the combination of glabridin and essence can effectively achieve the purpose of whitening and anti-aging. However, the traditional glabridin has poor purity during the extraction process and high purification cost, which increases the production cost of the essence. Therefore, a glabridin essence and preparation process are proposed. Summary of the invention

[0005] In view of the deficiencies in the prior art, the present invention provides a glabridin essence and a preparation process, which have the advantages of improving the extraction purity of glabridin and reducing the production cost of the essence, and solves the problem that the combination of glabridin and essence can effectively achieve the purpose of whitening and anti-aging, but the traditional glabridin has poor purity during the extraction process and high purification cost, thereby increasing the production cost of the essence.

[0006] To achieve the above object, the present invention provides the following technical solution: a glabridin essence, which is prepared from the following raw materials in percentage by weight: 85-92% water, 2-4% methylpropanediol, 1-3% butylene glycol, 1-3% niacinamide, 1.0-2.1% glabridin, 0.2-0.6% raspberry ketone glucoside, 0.3-0.5% p-hydroxyacetophenone, 0.3-0.6% 1,2-hexanediol, 0.2-0.5% rutin, 0.2-0.4% anorthine, 0.2-0.4% turmeric. Gel turmeric gum 0.1-0.3%, acrylates / C10-30 alkyl acrylate crosspolymer 0.13-0.18%, arginine 0.12-0.16%, hydroxyethylcellulose 0.03-0.05%, disodium EDTA 0.02-0.05%, sodium hyaluronate 0.01-0.03%, PEG-40 hydrogenated castor oil 0.002-0.004% and fragrance 0.001-0.002%.

[0007] Preferably, the water comprises 89.275%, 3% methylpropanediol, 2% butylene glycol, 2% niacinamide, 1.1% glabridin, 0.5% raspberry ketone glucoside, 0.4% p-hydroxyacetophenone, 0.4% 1,2-hexanediol, 0.4% rhubarb crystal, 0.3% anuoin, 0.2% Turmeric Gel, 0.15% acrylates / C10-30 alkyl acrylate crosspolymer, 0.15% arginine, 0.05% hydroxyethyl cellulose, 0.05% disodium EDTA, 0.02% sodium hyaluronate, 0.004% PEG-40 hydrogenated castor oil and 0.001% flavor.

[0008] Preferably, the glabridin is composed of glabridin extract and butylene glycol, wherein butylene glycol accounts for 80-90% and the glabridin extract accounts for 10-20%, and the Ruofu crystal is made of the following raw materials in weight percentage: 50-55% of Astragalus membranaceus root extract, 20-30% of water, 8-10% of Paeonia lactiflora root extract, 3-6% of butylene glycol, 4-5% of 1,2-pentanediol, 2.0-2.5% of Scutellaria baicalensis root extract and 2.2-2.8% of Bletilla striata root extract.

[0009] Preferably, the Anuoin is made of the following raw materials in weight percentage: 45-52% glycerol glucoside, 40-48% water and 4-6% 1,2-pentanediol, and the Turmeric Gel is made of the following raw materials in weight percentage: 78-82% turmeric root extract, 11.5-12.5% ​​lactobacillus fermentation product, 4-6% butylene glycol and 1-3% 1,2-pentanediol.

[0010] Preferably, the acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer includes one or more combinations of methyl acrylate, ethyl acrylate, 2-methyl methacrylate and 2-ethyl methacrylate.

[0011] A preparation process of glabridin essence, including the preparation method of glabridin essence, wherein the specific steps of the preparation method are as follows:

[0012] 1) Add water to a clean and disinfected water pot, then add acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer and hydroxyethyl cellulose and stir to dissolve completely for 15 minutes, then add methyl propanediol, butylene glycol, niacinamide, glabridin, p-hydroxyacetophenone, 1,2-hexanediol, anolin, disodium EDTA and sodium hyaluronate in turn, stir and heat until the temperature reaches 83-87°C, and set aside;

[0013] 2) Open the emulsifying pot, pump the raw materials in the water pot, and keep warm for 10 minutes;

[0014] 3) Cool down to 60 degrees and add raspberry ketone glucoside;

[0015] 4) Cool down to 45 degrees, add turmeric gel, arginine, PEG-40 hydrogenated castor oil and essence mixture;

[0016] 5) Take the material and send it to QC for inspection. After passing the inspection, filter it through 200 mesh and discharge it;

[0017] 7) Semi-finished products are filled after passing the inspection, and finished products are put into storage after passing the inspection.

[0018] Preferably, the extraction steps of glabridin are as follows:

[0019] 1) extracting liquorice waste residue with ethanol-water mixed solvent at room temperature, and filtering the primary extract with diatomaceous earth to remove impurities;

[0020] 2) The primary extract was injected into a supercritical carbon dioxide extraction device at a pressure of 25 MPa and a temperature of 45°C, and fat-soluble impurities were removed by reverse extraction to collect the target components;

[0021] 3) The purified solution is crystallized at -20°C, and centrifuged to obtain glabridin crystals with a purity of ≥99.5%.

[0022] Preferably, after the glabridin is extracted, nano-encapsulation targeted delivery is used to improve the water solubility and transdermal absorption efficiency of glabridin, and the specific steps are as follows;

[0023] 1) Glycyrrhizin and hydrogenated soybean lecithin are dissolved in a supercritical CO2 solvent at a mass ratio of 1:10, and then spray-dried under reduced pressure to form nano-scale composite particles;

[0024] 2) The signal peptide is coupled to the surface of the nanoparticles via a thioether bond, and the modification density is controlled using a microfluidic chip.

[0025] Preferably, the carbon dioxide supercritical extraction specifically comprises the following steps:

[0026] 1) Stage 1: 15MPa / 40℃, removal of low polar impurities;

[0027] 2) Stage 2: 28MPa / 50℃, adding ethanol entrainer to extract glabridin and flavonoids;

[0028] 3) Stage 3: Collect components of different polarity in different grades through a multi-stage vacuum separator;

[0029] 4) Apply 40kHz ultrasonic waves in the extraction kettle to destroy the plant cell walls;

[0030] 5) Using cellulase to hydrolyze liquorice waste residue.

[0031] Compared with the prior art, the technical solution of this application has the following beneficial effects:

[0032] 1. The present invention adds glabridin and a variety of plant extracts to the essence, the process is simple and convenient, the produced essence is very stable, easy to absorb, moisturizing, and whitening, and can effectively inhibit the production of melanin. It not only plays the role of a daily skin care supplement, but also can protect the skin. It is worth noting that the essence is the highest concentration of the skin care product, and the dosage must meet certain standards.

[0033] 2. The present invention solves the problems of low solubility, poor skin penetration and single efficacy in the traditional application of glabridin through high-purity extraction, targeted delivery and synergistic effect of composite active ingredients. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 The present invention is a flow chart for preparing the glabridin essence solution. DETAILED DESCRIPTION

[0035] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0036] Embodiment 1

[0037] A glabridin essence in the present embodiment is made of the following raw materials in percentage by weight: 89.275% water, 3% methylpropanediol, 2% butylene glycol, 2% niacinamide, 1.1% glabridin, 0.5% raspberry ketone glucoside, 0.4% p-hydroxyacetophenone, 0.4% 1,2-hexanediol, 0.4% rhubarb crystal, 0.3% anuoin, 0.2% Turmeric Gel, 0.15% acrylates / C10-30 alkyl acrylate cross-linked polymer, 0.15% arginine, 0.05% hydroxyethyl cellulose, 0.05% disodium EDTA, 0.02% sodium hyaluronate, 0.004% PEG-40 hydrogenated castor oil and 0.001% flavor.

[0038] In this embodiment, glabridin is composed of 10% glabridin extract and 90% butylene glycol, and the Ruofu crystal is made of the following raw materials in weight percentage: 55% Astragalus membranaceus root extract, 20% water, 10% Paeonia lactiflora root extract, 5% butylene glycol, 5% 1,2-pentanediol, 2.5% Scutellaria baicalensis root extract and 2.5% Bletilla striata root extract.

[0039] In this embodiment, Annoin is made of the following raw materials in weight percentage: 50% glycerol glucoside, 45% water and 5% 1,2-pentanediol, and Turmeric Gel is made of the following raw materials in weight percentage: 80.5% turmeric root extract, 12.5% ​​lactobacillus fermentation product, 5% butylene glycol and 2% 1,2-pentanediol.

[0040] Embodiment 2

[0041] A glabridin essence is prepared from the following raw materials in percentage by weight: 85-92% water, 2-4% methylpropanediol, 1-3% butylene glycol, 1-3% nicotinamide, 1.0-2.1% glabridin, 0.2-0.6% raspberry ketone glucoside, 0.3-0.5% p-hydroxyacetophenone, 0.3-0.6% 1,2-hexanediol, 0.2-0.5% rutin, 0.2-0.4% anorin, 0.2-0.4% turmeric Ge l Turmeric gum 0.1-0.3%, acrylates / C10-30 alkyl acrylate crosspolymer 0.13-0.18%, arginine 0.12-0.16%, hydroxyethyl cellulose 0.03-0.05%, disodium EDTA 0.02-0.05%, sodium hyaluronate 0.01-0.03%, PEG-40 hydrogenated castor oil 0.002-0.004% and fragrance 0.001-0.002%.

[0042] In this embodiment, glycyrrhizin is composed of glycyrrhizin extract and butylene glycol, wherein butylene glycol accounts for 80% and glycyrrhizin extract accounts for 20%. The Ruofu crystal is made of the following raw materials in weight percentage: 54% Astragalus membranaceus root extract, 23% water, 8% Paeonia lactiflora root extract, 5% butylene glycol, 5% 1,2-pentanediol, 2.2% Scutellaria baicalensis root extract and 2.8% Bletilla striata root extract.

[0043] In this embodiment, Annoin is made of the following raw materials in weight percentage: 48% glyceryl glucoside, 46% water and 6% 1,2-pentanediol, and Turmeric Gel is made of the following raw materials in weight percentage: 79% turmeric root extract, 12% lactobacillus fermentation product, 6% butylene glycol and 3% 1,2-pentanediol.

[0044] Embodiment 3

[0045] See also Figure 1 A preparation process of glabridin essence, using the raw materials of embodiment 1 and embodiment 2 respectively, and preparing glabridin essence through the following steps:

[0046] 1) Add water to a clean and disinfected water pot, then add acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer and hydroxyethyl cellulose and stir to dissolve completely for 15 minutes, then add methyl propanediol, butylene glycol, niacinamide, glabridin, p-hydroxyacetophenone, 1,2-hexanediol, anolin, disodium EDTA and sodium hyaluronate in turn, stir and heat until the temperature reaches 83-87°C, and set aside;

[0047] 3) Open the emulsifying pot, pump the raw materials in the water pot, and keep warm for 10 minutes;

[0048] 4) Cool down to 60 degrees and add raspberry ketone glucoside;

[0049] 5) Cool down to 45 degrees, add turmeric gel, arginine, PEG-40 hydrogenated castor oil and essence mixture;

[0050] 6) Take the material and send it to QC for inspection. After passing the inspection, filter it through 200 mesh and discharge it;

[0051] 7) Semi-finished products are filled after passing the inspection, and finished products are put into storage after passing the inspection.

[0052] In this embodiment, the extraction steps of glabridin are as follows:

[0053] 1) extracting liquorice waste residue with ethanol-water mixed solvent at room temperature, and filtering the primary extract with diatomaceous earth to remove impurities;

[0054] 2) The primary extract was injected into a supercritical carbon dioxide extraction device at a pressure of 25 MPa and a temperature of 45°C, and fat-soluble impurities were removed by reverse extraction to collect the target components;

[0055] 3) The purified solution is crystallized at -20°C and centrifuged to obtain glabridin crystals with a purity of ≥99.5%

[0056] After the glabridin extraction is completed, nano-encapsulation targeted delivery is used to improve the water solubility and transdermal absorption efficiency of glabridin. The specific steps are as follows;

[0057] 1) Glabridin and hydrogenated soybean lecithin were dissolved in a supercritical CO2 solvent at a mass ratio of 1:10, and then vacuum-reduced spray drying was performed to form nano-scale composite particles.

[0058] 2) The signal peptide is coupled to the surface of the nanoparticles via a thioether bond, and the modification density is controlled using a microfluidic chip.

[0059] In this embodiment, the specific steps of supercritical carbon dioxide extraction are as follows:

[0060] 1) Stage 1: 15MPa / 40℃, removal of low polar impurities;

[0061] 2) Stage 2: 28MPa / 50℃, adding ethanol entrainer to extract glabridin and flavonoids;

[0062] 3) Stage 3: Collect components of different polarities in different stages through a multi-stage vacuum separator;

[0063] 4) Apply 40kHz ultrasonic waves in the extraction kettle to destroy the plant cell walls;

[0064] 5) Using cellulase to hydrolyze liquorice waste residue.

[0065] In summary, the present invention adds glabridin and a variety of plant extracts into the essence, the process is simple and convenient, the produced essence is very stable, easy to absorb, moisturizing and whitening, and can effectively inhibit the production of melanin. It not only plays the role of daily skin care tonic, but also can protect the skin. It is worth noting that the essence is the highest concentration of skin care products, and the dosage must have a certain standard. Through high-purity extraction, targeted delivery and the synergistic effect of composite active ingredients, the low solubility, poor transdermal penetration and single efficacy of glabridin in traditional applications are solved. The traditional glabridin has poor purity in the extraction process and high purification cost, which increases the production cost of the essence.

[0066] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the existence of other identical elements in the process, method, article or device including the elements.

[0067] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A glabridin essence, characterized in that: The invention is prepared from the following raw materials in percentage by weight: 85-92% water, 2-4% methyl propanediol, 1-3% butylene glycol, 1-3% nicotinamide, 1.0-2.1% glabridin, 0.2-0.6% raspberry ketone glucoside, 0.3-0.5% p-hydroxyacetophenone, 0.3-0.6% 1,2-hexanediol, 0.2-0.5% rutin, 0.2-0.4% anorthine, turmeric Gel turmeric gum 0.1-0.3%, acrylates / C10-30 alkyl acrylate crosspolymer 0.13-0.18%, arginine 0.12-0.16%, hydroxyethylcellulose 0.03-0.05%, disodium EDTA 0.02-0.05%, sodium hyaluronate 0.01-0.03%, PEG-40 hydrogenated castor oil 0.002-0.004% and fragrance 0.001-0.002%.

2. The glabridin essence according to claim 1, characterized in that: The composition comprises 89.275% water, 3% methylpropanediol, 2% butylene glycol, 2% niacinamide, 1.1% glabridin, 0.5% raspberry ketone glucoside, 0.4% p-hydroxyacetophenone, 0.4% 1,2-hexanediol, 0.4% rhubarb crystal, 0.3% anol, 0.2% turmeric gel, 0.15% acrylates / C10-30 alkyl acrylate crosspolymer, 0.15% arginine, 0.05% hydroxyethyl cellulose, 0.05% disodium EDTA, 0.02% sodium hyaluronate, 0.004% PEG-40 hydrogenated castor oil and 0.001% flavor.

3. The glabridin essence according to claim 1, characterized in that: The glabridin is composed of glabridin extract and butylene glycol, wherein butylene glycol accounts for 80-90% and the glabridin extract accounts for 10-20%. The rutin crystal is made of the following raw materials in weight percentage: 50-55% of Astragalus membranaceus root extract, 20-30% of water, 8-10% of Paeonia lactiflora root extract, 3-6% of butylene glycol, 4-5% of 1,2-pentanediol, 2.0-2.5% of Scutellaria baicalensis root extract and 2.2-2.8% of Bletilla striata root extract.

4. The glabridin essence according to claim 1, characterized in that: The Annoin is made of the following raw materials in weight percentage: 45-52% of glycerol glucoside, 40-48% of water and 4-6% of 1,2-pentanediol; the Turmeric Gel is made of the following raw materials in weight percentage: 78-82% of turmeric root extract, 11.5-12.5% ​​of lactobacillus fermentation product, 4-6% of butylene glycol and 1-3% of 1,2-pentanediol.

5. The glabridin essence according to claim 1, characterized in that: The acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer includes one or a combination of methyl acrylate, ethyl acrylate, 2-methyl methacrylate and 2-ethyl methacrylate.

6. A process for preparing glabridin essence, comprising the method for preparing glabridin essence according to any one of claims 1 to 5, characterized in that: The specific steps of the production method are as follows: 1) Add water to a clean and disinfected water pot, then add acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer and hydroxyethyl cellulose and stir to dissolve completely for 15 minutes, then add methyl propanediol, butylene glycol, niacinamide, glabridin, p-hydroxyacetophenone, 1,2-hexanediol, anolin, disodium EDTA and sodium hyaluronate in turn, stir and heat until the temperature reaches 83-87°C, and set aside; 3) Open the emulsifying pot, pump the raw materials in the water pot, and keep warm for 10 minutes; 4) Cool down to 60 degrees and add raspberry ketone glucoside; 5) Cool down to 45 degrees, add turmeric gel, arginine, PEG-40 hydrogenated castor oil and essence mixture; 6) Take the material and send it to QC for inspection. After passing the inspection, filter it through 200 mesh and discharge it; 7) Semi-finished products are filled after passing the inspection, and finished products are put into storage after passing the inspection.

7. The process for preparing the glabridin essence according to claim 6, characterized in that: The extraction steps of the glabridin are specifically as follows: 1) extracting liquorice waste residue with ethanol-water mixed solvent at room temperature, and filtering the primary extract with diatomaceous earth to remove impurities; 2) The primary extract was injected into a supercritical carbon dioxide extraction device at a pressure of 25 MPa and a temperature of 45°C, and fat-soluble impurities were removed by reverse extraction to collect the target components; 3) The purified solution is crystallized at -20°C, and centrifuged to obtain glabridin crystals with a purity of ≥99.5%.

8. The process for preparing the glabridin essence according to claim 7, characterized in that: After the glabridin is extracted, nano-encapsulation targeted delivery is used to improve the water solubility and transdermal absorption efficiency of glabridin, and the specific steps are as follows; 1) Glycyrrhizin and hydrogenated soybean lecithin are dissolved in a supercritical CO2 solvent at a mass ratio of 1:10, and then spray-dried under reduced pressure to form nano-scale composite particles; 2) The signal peptide is coupled to the surface of the nanoparticles via a thioether bond, and the modification density is controlled using a microfluidic chip.

9. The process for preparing the glabridin essence according to claim 8, characterized in that: The specific steps of the carbon dioxide supercritical extraction are as follows: 1) Stage 1: 15MPa / 40℃, removal of low polar impurities; 2) Stage 2: 28MPa / 50℃, adding ethanol entrainer to extract glabridin and flavonoids; 3) Stage 3: Collect components of different polarities in different stages through a multi-stage vacuum separator; 4) Apply 40kHz ultrasonic waves in the extraction kettle to destroy the plant cell walls; 5) Using cellulase to hydrolyze liquorice waste residue.

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