Hemoperfusion support device and dialysis machine combining hemoperfusion and hemodialysis

Abstract

This invention discloses a hemoperfusion support device and a dialysis machine for combined hemoperfusion and hemodialysis, including a mounting base, a right telescopic cylinder I, an L-shaped bracket, a hemoperfusion bracket rotation motor, a dialyzer bracket rotation motor, a hemoperfusion bracket, and a dialyzer bracket. The L-shaped bracket is fixedly connected to the right telescopic cylinder I. The dialyzer bracket rotation motor is fixedly mounted on the top of the L-shaped bracket. The dialyzer bracket is mounted on the power output shaft of the dialyzer bracket rotation motor. The hemoperfusion bracket rotation motor is fixedly mounted on the bottom right end of the L-shaped bracket. This hemoperfusion support device and dialysis machine achieve automatic rotation, tilting, and vibration, thereby achieving automatic air venting and impurity removal from the hemoperfusion device and dialyzer without manual operation. The hemoperfusion device and dialyzer can be pre-flushed, vented, and impurity removed simultaneously, saving time, reducing reliance on medical personnel, and reducing the risk of infection from manual operation when connecting arterial and venous puncture needles.

Description

Technical Field

[0001] This invention relates to the field of hemodialysis technology, specifically to a hemoperfusion support device and a dialysis machine that combines hemoperfusion with hemodialysis. Background Technology

[0002] Hemoperfusion devices are mainly used for the adsorption of molecular toxins in acute and chronic drug poisoning and uremia, as well as for the adsorption of pathogenic factors in liver disease and the immune system. Their main applications include standalone hemoperfusion, hemodialysis combined with hemoperfusion, and plasma separation and adsorption. The hemodialysis combined with hemoperfusion mode overcomes the limitations of hemodialysis alone in effectively removing medium and large molecular toxins, protein-bound toxins, and various inflammatory mediators. However, because the overall structure, connection methods, and priming methods of the combined artificial kidney extracorporeal circulation are more complex than those of simple dialysis, the risks of infection and coagulation for patients are increased.

[0003] During hemoperfusion combined with hemodialysis, the dialyzer is mounted on a stent clamp, and the perfusion device is mounted on another stent clamp with the venous end of the perfusion device facing upwards. The arterial and venous lines of the perfusion device are connected, and the venous end of the dialyzer is also facing upwards. The dialysis venous line is connected to the venous end of the dialyzer. The stent is manually rotated, and the dialysis arterial line is connected to the arterial end of the dialyzer. The stent is then manually reversed to bring the venous end of the dialyzer back to the top. The perfusion device is pre-primed, following the rapid air purging guide to fully expel air and particles. First, the perfusion device is manually removed, the pre-priming solution is turned on, and air and particles are expelled from the arterial end and the column. The perfusion device is manually tilted at a horizontal angle of approximately 30–60°, while the other hand holds the air purging hammer and continuously taps the bottom of the perfusion device. Second, air is purged from the venous end by holding the device vertically to expel air bubbles. After the perfusion device is vented and particles are removed, the dialyzer is pre-flushed. When the pre-flushing and venting operation begins, the pre-flushing fluid enters the dialyzer from the arterial end at the bottom and exits from the venous end at the top, thereby removing gas and impurities from the dialyzer membrane. To better remove gas and impurities from the dialyzer membrane, the operator needs to tap the dialyzer or remove it and rub it. After the gas in the dialyzer membrane is removed, the bypass interface on the side wall of the dialyzer is connected to the bypass line. The stand is then manually rotated again so that the arterial end of the dialyzer is higher than the venous end. The dialysate enters the dialyzer from the bypass line at the bottom and exits from the bypass line at the top, thereby rinsing the outside of the dialyzer membrane. After the pre-rinsing is completed, the other end of the dialysis arterial line and dialysis venous line is connected to the patient's arterial and venous puncture needles, and hemoperfusion dialysis can then begin.

[0004] Existing methods for pre-flushing the perfusion apparatus and dialyzer reveal that the inversion, tilting, and tapping of both are manual operations. The entire process requires manual intervention to completely expel gas and particles from the perfusion apparatus, impurities from the dialyzer, and gases from both inside and outside the dialyzer membrane. This entirely depends on the medical staff's adherence to procedures and their diligence. Careless operation or interruptions can prevent the complete removal of these components, potentially leading to embolism. Furthermore, manual inversion, tilting, and tapping require contact with different parts of the perfusion apparatus, dialyzer, and stent at varying times, increasing the risk of infection when connecting arterial and venous puncture needles. Medical staff must pre-flush and vent the perfusion apparatus before pre-flushing and venting the dialyzer, making simultaneous operation impossible and thus increasing the overall time required. Summary of the Invention

[0005] To address the shortcomings of the existing technology, the present invention provides a hemoperfusion support device that reduces manual operation and can automatically realize the flipping, tilting, and vibration of the perfusion device and dialyzer, as well as a dialysis machine for combined hemoperfusion and hemodialysis.

[0006] To solve the above-mentioned technical problems, the present invention adopts the following technical solution:

[0007] A hemoperfusion device support device includes a mounting base, a right telescopic cylinder I, an L-shaped bracket, a hemoperfusion device bracket rotation motor, a dialyzer bracket rotation motor, a hemoperfusion device bracket, and a dialyzer bracket. The right telescopic cylinder I is fixedly connected to the mounting base, with its piston rod extending horizontally to the right. The L-shaped bracket is fixedly connected to the piston rod of the right telescopic cylinder I. The dialyzer bracket rotation motor is fixedly mounted on the top of the L-shaped bracket, with its power output shaft extending to the right. The dialyzer bracket is mounted on the dialyzer bracket rotation motor. The bottom of the L-shaped support extends from below the dialyzer support to the right on the power output shaft of the motor. The perfusion device support rotation motor is fixedly installed on the bottom right end of the L-shaped support. The power output shaft of the perfusion device support rotation motor extends to the right, and the perfusion device support is mounted on the power output shaft of the perfusion device support rotation motor. The perfusion device support includes a U-shaped frame, a left perfusion device support frame, and a right perfusion device support frame. The middle left side of the U-shaped frame is fixedly connected to the power output shaft of the perfusion device support rotation motor, and the left perfusion device support frame is mounted on the U-shaped frame. The right support frame of the irrigation device is installed at the top right side of the U-shaped frame, and the left and right support frames of the irrigation device are symmetrically arranged on the U-shaped frame. The left support frame of the irrigation device includes a left guide sleeve, a left cylinder II, a left guide plate, a left sliding sleeve, a left spring, a left clamping plate, a left pull rope, and a left vibration motor of the irrigation device. The left guide sleeve is fixed to the top left side of the U-shaped frame, with the open end of the left guide sleeve facing to the right. The left cylinder II is installed on the left side inside the left guide sleeve. The left guide plate is fixedly arranged on the cross-section inside the left guide sleeve. The left sliding sleeve passes through... The left sliding sleeve passes through a through hole in the middle of the left guide plate and slides in cooperation with the left guide plate. The left end of the left sliding sleeve is fixedly connected to the piston rod of the left cylinder II. The left spring is sleeved on the left sliding sleeve, and the left end of the left spring is fixed to the left guide plate. The right end of the left spring extends out of the right end of the left guide sleeve and is fixedly connected to the left clamping plate. The left pull rope passes through the left sliding sleeve, and the left end of the left pull rope is fixedly connected to the piston rod of the left cylinder II. The right end of the left pull rope is fixedly connected to the left side of the left clamping plate. The left vibration motor of the irrigation device is fixedly installed on the left side of the left clamping plate near the bottom or near the top.

[0008] In a preferred embodiment of the present invention, the right support frame of the irrigation device includes a right guide sleeve, a right cylinder III, a right guide plate, a right sliding sleeve, a right spring, a right clamping plate, a right pull rope, and a right vibration motor for the irrigation device. The right guide sleeve is fixed to the top right side of the U-shaped frame, with the open end of the right guide sleeve facing left. The right cylinder III is installed on the right side inside the right guide sleeve. The right guide plate is fixedly arranged on the cross-section inside the right guide sleeve. The right sliding sleeve passes through a through hole in the middle of the right guide plate and slides in cooperation with the right guide plate. The right end of the right sliding sleeve is engaged with the piston of the right cylinder III. The rod is fixedly connected. The right spring is sleeved on the right sliding sleeve. The right end of the right spring is fixed to the right guide plate. The left end of the right spring extends out of the left end of the right guide sleeve and is fixedly connected to the right clamping plate. The right pull rope passes through the right sliding sleeve. The right end of the right pull rope is fixedly connected to the piston rod of the right cylinder III. The left end of the right pull rope is fixedly connected to the right side of the right clamping plate. The right vibration motor of the irrigation device is fixedly installed on the right side of the right clamping plate near the bottom or near the top. Both the left and right clamping plates are arc-shaped plates, and the concave arc surfaces of the left and right clamping plates correspond to each other.

[0009] As a preferred embodiment of the present invention, the right end of the left sliding sleeve is provided with a concave arc-shaped end that can fit with the left outer wall of the left clamping plate, and the left end of the right sliding sleeve is provided with a concave arc-shaped end that can fit with the right outer wall of the right clamping plate; the bottom of the U-shaped frame is provided with a backward-curved semi-circular frame near the middle.

[0010] In a preferred embodiment of the present invention, the dialyzer support includes a left support plate and a right support plate; both the left and right support plates are arc-shaped plates, with their concave arc surfaces corresponding to each other, their rear ends hinged together, and a dialyzer insertion end formed between their front ends; the power output shaft of the dialyzer support rotation motor is fixedly connected to the left side of the left support plate; the left and right support plates are equipped with a clamping mechanism for holding the dialyzer and a vibration mechanism for vibrating the dialyzer.

[0011] In a preferred embodiment of the present invention, the vibration mechanism includes a left vibration mechanism installed in the middle of the inner side of the left support plate and a right vibration mechanism installed in the middle of the inner side of the right support plate. Both the left and right vibration mechanisms include a cylinder IV, a guide cylinder with one open end, a vibration spring, a vibration clamping plate, and a dialyzer vibration motor. The middle of both the left and right support plates is provided with mounting holes for cylinder IV. The cylinder IV on the left side is fixedly installed in the mounting hole on the left support plate, and the cylinder IV on the right side is fixedly installed in the mounting hole on the right support plate. The piston rod of the cylinder IV faces inward, and the guide cylinder is fixedly connected... On the piston rod of cylinder IV, one end of the vibration spring is fixedly connected to the inner end wall of the guide cylinder, and the other end of the vibration spring extends out of the open end of the guide cylinder and is fixedly connected to the vibration clamping plate. The outer diameter of the guide cylinder is smaller than the inner diameter of the mounting hole of cylinder IV. The vibration clamping plate is an arc-shaped plate. The concave arc surfaces of the left and right vibration clamping plates correspond to each other. The left and right vibration clamping plates are used to clamp the dialyzer during vibration. The left dialyzer vibration motor is installed at the bottom left side of the left vibration clamping plate, and the right dialyzer vibration motor is installed at the top right side of the right vibration clamping plate.

[0012] In a preferred embodiment of the present invention, clamping mechanisms are installed on the inner sides of the left support plate near the upper and lower sides, and on the inner sides of the right support plate near the upper and lower sides. Each clamping mechanism includes a clamping cylinder V and a clamping plate. Cylinder V mounting holes are provided on the inner sides of the left support plate near the upper and lower sides, and on the inner sides of the right support plate near the upper and lower sides. Each cylinder V mounting hole contains a clamping cylinder V. The piston rod of the clamping cylinder V faces inward, and the piston rod is fixedly connected to the clamping plate. The clamping plate is an arc-shaped plate. The clamping plates on the inner sides of the left and right support plates near the upper sides form a set of dialyzer clamping plates. The clamping plates on the inner sides of the left and right support plates near the lower sides form another set of dialyzer clamping plates.

[0013] In a preferred embodiment of the present invention, the rear ends of the left and right support plates are hinged to each other by a positioning and rotating mechanism. The positioning and rotating mechanism includes a positioning shaft and a torque spring. The rear end of the left support plate is provided with at least two inner grooves near its inner side. The rear end of the right support plate is provided with an outwardly protruding rotating arm that is equal in number to the number of inner grooves and cooperates with them. The rear end of the left support plate and the outwardly protruding rotating arm are both provided with through holes I. The outwardly protruding rotating arm on the rear end of the right support plate is located in the corresponding inner groove on the rear end of the left support plate. The positioning shaft passes through the through hole I on the rear end of the left support plate and the through hole I on the outwardly protruding rotating arm. A torque spring is sleeved on the positioning shaft in each inner groove and at both ends of the corresponding outwardly protruding rotating arm. One end of the torque spring is fixedly connected to the side wall of the corresponding inner groove, and the other end of the torque spring is fixedly connected to the corresponding outwardly protruding rotating arm. When the torque spring is in its natural state, the snap-fit ​​ends of the front ends of the left and right support plates are close to each other.

[0014] As a preferred embodiment of the present invention, the inner sides of the left clamping plate, the right clamping plate, the vibrating clamping plate and the clamping plate are all provided with rubber pads, and a pressure sensor and an tilt sensor are installed on the inner side of each rubber pad.

[0015] A dialysis machine combining hemoperfusion and hemodialysis includes a dialysis machine body and the aforementioned hemoperfusion device support. The mounting base includes a snap-in section and an external section. The snap-in section has a rectangular cross-section, and each of its four sides has a slot. A rectangular snap-fit ​​hole is located on the front side and near the right side of the dialysis machine body. Each side of the inner wall of the snap-fit ​​hole has a mounting hole corresponding to the slot. The mounting hole consists of a smaller diameter circular hole section I near the inner side and a larger diameter circular hole section II near the outer side. A locking mechanism is installed in each mounting hole. The locking mechanism includes a cylinder VI, a fixing plate, a guide locking sleeve, a locking pin, a locking spring, and a locking rope. The cylinder VI is installed inside the circular hole section I, and the fixing plate is snapped inside the circular hole section II and abuts against the step formed between the circular hole sections I and II. A guide hole is provided in the middle of the fixed plate. The guide locking sleeve passes through the guide hole and slides in cooperation with it. The locking pin is set in the circular hole section II and slides in cooperation with the inner wall of the circular hole section II. The inner end of the locking pin is fixedly connected to the outer end of the guide locking sleeve. The piston rod of cylinder VI extends to the inner end of the guide locking sleeve. The locking spring is sleeved outside the guide locking sleeve and located between the locking pin and the fixed plate. One end of the locking spring is fixed to the inner end of the locking pin, and the other end is fixed to the fixed plate. The locking pull rope passes through the guide locking sleeve. One end of the locking pull rope is fixedly connected to the inner end of the locking pin, and the other end is fixedly connected to the piston rod of cylinder VI. The snap-in section is inserted into the snap-in hole, and the outer end of the locking pin is inserted into the corresponding snap-in groove. The right telescopic cylinder I is fixedly connected to the front end of the outer section.

[0016] Furthermore, both the pressure sensor and the tilt sensor are electrically connected to the controller inside the dialysis machine body. The right telescopic cylinder I, the perfusion support rotation motor, the dialyzer support rotation motor, the left cylinder II, the right cylinder III, the perfusion left vibration motor, the perfusion right vibration motor, the cylinder IV, the dialyzer vibration motor, the clamping cylinder V, and the cylinder VI are all controlled by the controller inside the dialysis machine body.

[0017] Compared with the prior art, the beneficial effects of the present invention are:

[0018] 1. This hemoperfusion support device and its combined hemoperfusion and hemodialysis dialysis machine achieve automatic rotation, tilting, and vibration of the perfusion and dialyzers. This enables automatic air and impurity removal within the perfusion and dialyzers, eliminating the need for manual operation. Medical personnel only need to connect the venous, arterial, and bypass interfaces, significantly reducing manual operation and the chance of contact with the instruments. This also lowers the risk of infection associated with subsequent manual connection of arterial and venous puncture needles. Simultaneously, through automatic control, the perfusion and dialyzer can be pre-flushed and purged of air and impurities, saving time and preventing embolism risks caused by improper operation by medical personnel, which can lead to incomplete removal of impurities and gases from the dialyzer membrane. This greatly reduces reliance on medical personnel and ensures better pre-flushing and purging of gases and impurities from the perfusion and dialyzer membranes.

[0019] 2. When using this hemoperfusion combined with hemodialysis to pre-flush, vent, and remove particulate matter from the perfusion device, the piston rods of the left cylinder II and right cylinder III retract a short distance, causing the left sliding sleeve to disengage from the left clamp and the right sliding sleeve to disengage from the right clamp. The left and right pull ropes are also relaxed, allowing the perfusion device to be suspended on the U-shaped frame by the left and right springs. Turning on the left and right vibration motors of the perfusion device, with the infusion of pre-flushing fluid and the rotation of the perfusion device support motor driving the support to tilt forward or backward, causes the perfusion device to vibrate in multiple dimensions. This causes the gas and particulate matter inside the perfusion device, including the gas and particulate matter between, on, and on the solid adsorbent within the device, to move upwards in multiple dimensions and be discharged from the top of the perfusion device. This allows for the efficient and complete removal of all gas and particulate matter from the perfusion device in a short time.

[0020] 3. When using this hemoperfusion combined with hemodialysis to pre-purge, degas, and remove impurities from the dialyzer, insert the dialyzer between the left and right support plates. The controller controls the piston rod of cylinder IV to extend, and the piston rod drives the guide cylinder to move towards the center, thereby driving the vibration spring and vibration clamping plate to approach the dialyzer. The elastic pads on the inner sides of the left and right vibration clamping plates press against the left and right sides of the dialyzer and clamp it. Turn on the vibration motors of the dialyzer on both sides. At the same time, the dialyzer support rotation motor drives the dialyzer to tilt, and the tilt angle is transmitted through the elastic pads on the inner sides of the vibration clamping plates. The sensor detects the tilt angle of the dialyzer, facilitating precise control of the dialyzer's tilt angle. When the pre-flushing fluid passes through the dialyzer, the dialyzer vibration motors on the left and right support plates are at opposite heights. Under the synergistic effect of the dialyzer support rotation motor driving the dialyzer to tilt, the dialyzer moves in multiple dimensions. Driven by the pre-flushing fluid, air and impurities attached to the inner wall of the dialyzer and the fiber membrane inside the dialyzer can be quickly removed and discharged. Furthermore, after the dialyzer is tilted, it also facilitates the discharge of gas and impurities attached to the top of the dialyzer through the venous end or bypass tubing. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the main structure of the blood perfusion device support device;

[0022] Figure 2 This is a top view schematic diagram of the support structure of the blood perfusion device;

[0023] Figure 3 This is a schematic diagram of the perfusion device and dialyzer mounted on the blood perfusion device support.

[0024] Figure 4 This is a structural diagram of the mounting base;

[0025] Figure 5 This is a schematic diagram of the irrigation device support structure;

[0026] Figure 6 This is a structural diagram of a U-shaped frame;

[0027] Figure 7 This is a structural diagram of the left or right sliding sleeve;

[0028] Figure 8 This is a schematic diagram of the structure in which clamping and vibration mechanisms are installed inside the left and right support plates;

[0029] Figure 9 This is a structural schematic diagram of the left support plate;

[0030] Figure 10 This is a structural schematic diagram of the right support plate;

[0031] Figure 11This is a schematic diagram of the structure of the positioning and rotating mechanism cooperating with the right support plate;

[0032] Figure 12 This is a schematic diagram of a structure in which a pressure sensor and a tilt sensor are mounted on a rubber pad.

[0033] Figure 13 This is a schematic diagram of the hemoperfusion device support device installed on the main body of the dialysis machine;

[0034] Figure 14 This is a schematic diagram of the structure of the dialysis machine body with snap-fit ​​holes and mounting holes;

[0035] Figure 15 This is a cross-sectional diagram of the mounting base inserting into the snap-fit ​​hole on the main body of the dialysis machine.

[0036] Figure 16 yes Figure 15 Enlarged structural diagram at point A;

[0037] Figure 17 This is a schematic diagram of the perfusion device and dialyzer installed on the dialysis machine.

[0038] In the diagram: 1—Mounting base; 101—Snap-in section; 102—External connection section; 103—Slot; 2—Right telescopic cylinder I; 3—L-shaped bracket; 4—Irrigator bracket rotating motor; 5—Dialyzer bracket rotating motor; 6—Irrigator bracket; 61—U-shaped frame; 611—Semi-circular frame; 62—Left guide sleeve; 63—Left cylinder II; 64—Left guide plate; 65—Left sliding sleeve; 66—Left spring; 67—Left clamping plate; 68—Left pull rope; 69—Irrigator left vibration motor; 70—Right guide sleeve; 71—Right cylinder III; 72—Right guide plate; 73—Right sliding sleeve; 74—Right spring; 75—Right clamping plate; 76—Right pull rope; 77—Irrigator right vibration motor; 78—Arc-shaped end; 8—Dialyzer bracket; 81—Left support plate; 82—Right support plate; 83—Clamping mechanism; 831— 832—Clamping cylinder V; 833—Cylinder V mounting hole; 84—Vibration mechanism; 841—Cylinder IV; 842—Guide cylinder; 843—Vibration spring; 844—Vibration clamping plate; 845—Dialyzer vibration motor; 846—Cylinder IV mounting hole; 85—Positioning shaft; 86—Torque spring; 87—Inner groove; 88—Outer convex rotating arm; 89—Through hole I; 90—Rubber pad; 91—Pressure sensor; 92—Tilt sensor; 10—Irrigation device; 11—Dialyzer; 12—Dialyzer body; 13—Snap-fit ​​hole; 14—Mounting hole; 15—Locking mechanism; 151—Cylinder IV; 152—Fixing plate; 153—Guide locking sleeve; 154—Locking pin; 155—Locking spring; 156—Locking rope; 16—Base; 17—Support arm; 18—Support rod. Detailed Implementation

[0039] The present invention will now be described in detail with reference to the embodiments and accompanying drawings.

[0040] like Figures 1-3 As shown, the hemoperfusion device support device includes a mounting base 1, a right telescopic cylinder I2, an L-shaped bracket 3, a hemoperfusion bracket rotation motor 4, a dialyzer bracket rotation motor 5, a hemoperfusion bracket 6, and a dialyzer bracket 8. The right telescopic cylinder I2 is fixedly connected to the mounting base 1. In this embodiment, the mounting base 1 includes a snap-in section 101 and an external section 102. The snap-in section 101 has a rectangular cross-section, and each of its four sides has a slot 103. Figure 4 As shown, the right telescopic cylinder I2 is fixedly connected to the front end of the external section 102. The piston rod of the right telescopic cylinder I2 extends horizontally to the right, and the left side of the L-shaped bracket 3 is fixedly connected to the piston rod of the right telescopic cylinder I2. The dialyzer bracket rotation motor 5 is fixedly installed on the top of the L-shaped bracket 3, and the power output shaft of the dialyzer bracket rotation motor 5 extends to the right. The dialyzer bracket 8 is installed on the power output shaft of the dialyzer bracket rotation motor 5. The bottom of the L-shaped bracket 3 extends to the right from below the dialyzer bracket 8. The perfusion bracket rotation motor 4 is fixedly installed on the bottom right end of the L-shaped bracket 3, and the power output shaft of the perfusion bracket rotation motor 4 extends to the right. The perfusion bracket 6 is installed on the power output shaft of the perfusion bracket rotation motor 4, and the perfusion bracket 6 is located on the lower right side of the dialyzer bracket 8.

[0041] The irrigation device support 6 includes a U-shaped frame 61, a left support frame for the irrigation device, and a right support frame for the irrigation device, such as... Figure 5 As shown. A backward-curving semi-circular frame 611 is provided at the bottom of the U-shaped frame 61 near the center, as... Figure 6 As shown, the semi-circular frame 611 is designed to guide the irrigation device 10 as it is inserted between the left and right support frames. With the bottom of the irrigation device 10 facing the semi-circular frame 611, the irrigation device 10 can be placed between the left and right support frames. This design also avoids obstructing the insertion of the irrigation device 10 and prevents it from vibrating and venting. The left middle part of the U-shaped frame 61 is fixedly connected to the power output shaft of the irrigation device support rotating motor 4. The left support frame is installed at the top left side of the U-shaped frame 61, and the right support frame is installed at the top right side of the U-shaped frame 61. The left and right support frames are symmetrically arranged on the U-shaped frame 61.

[0042] The left support frame of the irrigation device includes a left guide sleeve 62, a left cylinder II 63, a left guide plate 64, a left sliding sleeve 65, a left spring 66, a left clamping plate 67, a left pull rope 68, and a left vibration motor 69 for the irrigation device. Figure 5As shown. The left guide sleeve 62 is fixed to the top left side of the U-shaped frame 61, with its open end facing right. The left cylinder II 63 is installed inside the left guide sleeve 62 on the left side, with its piston rod facing right. The left guide plate 64 is fixedly installed on the cross-section inside the left guide sleeve 62. The left sliding sleeve 65 passes through a through hole in the middle of the left guide plate 64 and slides within the left guide plate 64. The left end of the left sliding sleeve 65 is fixedly connected to the piston rod of the left cylinder II 63. The left spring 66 is sleeved outside the left sliding sleeve 65. The left end of the left spring 66... The left end is fixed to the left guide plate 64. The right end of the left spring 66 extends out of the right end of the left guide sleeve 62 and is fixedly connected to the left clamping plate 67. The left pull rope 68 passes through the left sliding sleeve 65. The left end of the left pull rope 68 is fixedly connected to the piston rod of the left cylinder II 63, and the right end of the left pull rope 68 is fixedly connected to the left side of the left clamping plate 67. The left vibration motor 69 of the irrigation device is fixedly installed on the left side of the left clamping plate 67 near the bottom or near the top. In this embodiment, the left vibration motor 69 of the irrigation device is fixedly installed on the left side of the left clamping plate 67 near the bottom. The right support frame of the irrigation device includes a right guide sleeve 70, a right cylinder III 71, a right guide plate 72, a right sliding sleeve 73, a right spring 74, a right clamping plate 75, a right pull rope 76, and a right vibration motor 77 of the irrigation device. Figure 5 As shown; the right guide sleeve 70 is fixed to the top right side of the U-shaped frame 61, with the open end of the right guide sleeve 70 facing left. The left guide sleeve 62 is on the same horizontal axis as the right guide sleeve 70. The right cylinder III 71 is installed on the right side inside the right guide sleeve 70, with the piston rod of the right cylinder III 71 facing left. The right guide plate 72 is fixedly set on the cross-section inside the right guide sleeve 70. The right sliding sleeve 73 passes through the through hole in the middle of the right guide plate 72 and slides in cooperation with the right guide plate 72. The right end of the right sliding sleeve 73 is fixedly connected to the piston rod of the right cylinder III 71. The right spring 74 is sleeved on the right sliding sleeve 70. 3. In addition, the right end of the right spring 74 is fixed to the right guide plate 72, and the left end of the right spring 74 extends out of the left end of the right guide sleeve 70 and is fixedly connected to the right clamping plate 75. The right pull rope 76 passes through the right sliding sleeve 73, and the right end of the right pull rope 76 is fixedly connected to the piston rod of the right cylinder III 71. The left end of the right pull rope 76 is fixedly connected to the right side of the right clamping plate 75. The right vibration motor 77 of the irrigation device is fixedly installed on the right side of the right clamping plate 75 near the bottom or near the top. Both the left clamping plate 67 and the right clamping plate 75 are arc-shaped plates, and the concave arc-shaped surfaces of the left clamping plate 67 and the right clamping plate 75 correspond to each other. The right end of the left sliding sleeve 65 is provided with a concave arc-shaped end 78 that can fit against the left outer wall of the left clamping plate 67, and the left end of the right sliding sleeve 73 is provided with a concave arc-shaped end 78 that can fit against the right outer wall of the right clamping plate 75. Figure 7 As shown, the piston rod of the left cylinder II 63 extends to drive the left sliding sleeve 65 to approach and fit against the left outer wall of the left clamping plate 67. At the same time, the piston rod of the right cylinder III 71 extends to drive the right sliding sleeve 73 to approach and fit against the right outer wall of the right clamping plate 75. The arc-shaped end 78 can better fit against the left outer wall of the left clamping plate 67 and the right outer wall of the right clamping plate 75, thereby better clamping the irrigation device 10 and making the clamping more stable.

[0043] When using the irrigation device bracket 6, the piston rod of the left cylinder II 63 retracts, driving the left sliding sleeve 65 to move to the left. This, in turn, drives the left clamping plate 67 to move to the left via the left pull rope 68, compressing the left spring 66. Simultaneously, the piston rod of the right cylinder III 71 retracts, driving the right sliding sleeve 73 to move to the right. This, in turn, drives the right clamping plate 75 to move to the right via the right pull rope 76, compressing the right spring 74. The left and right clamping plates 67 and 75 then move away from each other. At this point, the irrigation device 10 is placed between the left and right clamping plates 67 and 75. The piston rods of the left cylinder II 63 and right cylinder III 71 extend. The extended piston rod of the left cylinder II 63 drives the left sliding sleeve 65 to press against the left clamping plate 67, making the left clamping plate 67 more firmly pressed against the left side of the irrigation device 10. The extended piston rod of the right cylinder III 71 drives the right sliding sleeve 73 to press against the right clamping plate 75, making the right clamping plate 75 more firmly pressed against the right side of the irrigation device 10. Figure 3 As shown, the irrigation device 10 is securely clamped. When it is necessary to pre-purge and vent the irrigation device 10, the piston rods of the left cylinder II 63 and the right cylinder III 71 retract a short distance, causing the left sliding sleeve 65 to leave the left clamping plate 67 and the right sliding sleeve 73 to leave the right clamping plate 75. The left pull rope 68 and the right pull rope 76 are in a relaxed state. The left clamping plate 67 presses the left side of the irrigation device 10 with the driving force of the left spring 66, and the right clamping plate 75 presses the right side of the irrigation device 10 with the driving force of the right spring 74. The perfusion device 10 is suspended on the U-shaped frame 61 by the left spring 66 and the right spring 74. When the left vibration motor 69 and the right vibration motor 77 of the perfusion device are turned on, with the injection of pre-flushing liquid, and the perfusion device support 6 is driven to tilt forward or backward by the rotation motor 5 of the perfusion device support, the perfusion device 10 is in multi-dimensional vibration. This causes the gas in the perfusion device 10, including the gas between the solid adsorbents, on the solid adsorbents, and on the inner wall of the perfusion device 10, to move upward in multiple dimensions and be discharged from the top of the perfusion device 10. This can achieve efficient and complete discharge of all the gas in the perfusion device 10 in a short time. After the gas and impurities inside the perfusion device 10 are discharged, the perfusion device support rotation motor 5 rotates, driving the perfusion device support 6 to a vertical position, that is, to make the perfusion device 10 vertical. The piston rods of the left cylinder II 63 and the right cylinder III 71 extend. The extension of the piston rod of the left cylinder II 63 drives the left sliding sleeve 65 to push against the left outer wall of the left clamping plate 67, and the extension of the piston rod of the right cylinder III 71 drives the right sliding sleeve 73 to push against the right outer wall of the right clamping plate 75. At this time, the perfusion device 10 is further clamped between the left clamping plate 67 and the right clamping plate 75 by the clamping force of the left sliding sleeve 65 pushed by the left cylinder II 63 and the right sliding sleeve 73 pushed by the right cylinder III 71.

[0044] The dialyzer support 8 includes a left support plate 81 and a right support plate 82, such as... Figures 1-3As shown, both the left support plate 81 and the right support plate 82 are arc-shaped plates. The concave arc surfaces of the left support plate 81 and the right support plate 82 correspond to each other, and the left support plate 81 and the right support plate 82 form an outer support ring. The rear ends of the left support plate 81 and the right support plate 82 are hinged to each other, and the front ends of the left support plate 81 and the right support plate 82 form the insertion end of the dialyzer 11. The insertion end has a figure-eight structure that opens forward and to both sides, which facilitates the insertion of the dialyzer 11 between the left support plate 81 and the right support plate 82. The power output shaft of the dialyzer support rotation motor 5 is fixedly connected to the left side of the left support plate 81. The left support plate 81 and the right support plate 82 are provided with a clamping mechanism 83 for clamping the dialyzer 11 and a vibration mechanism 84 for vibrating the dialyzer 11. When the dialyzer 11 is inserted between the outer support ring formed by the left support plate 81 and the right support plate 82 through the insertion end, the clamping mechanism 83 within the left support plate 81 and the right support plate 82 can clamp the dialyzer 11, such as Figure 3 As shown, at this time, the dialyzer support rotating motor 5 rotates, which can drive the left support plate 81 and the right support plate 82, as well as the clamping mechanism 83, the vibration mechanism 84 and the dialyzer 11 inside, to flip and tilt. When flipping, the venous end of the dialyzer 11 can be flipped to the bottom and the arterial end of the dialyzer 11 can be flipped to the top, which facilitates the connection of arteriovenous catheters. When the vibration mechanism 84 clamps the dialyzer 11 and the vibration mechanism 84 is turned on, under the synergistic effect of the dialyzer support rotating motor 5 driving the dialyzer 11 to tilt, the air and impurities in the dialyzer 11 can be completely and effectively expelled.

[0045] The vibration mechanism 84 includes a left vibration mechanism installed in the middle of the inner side of the left support plate 81 and a right vibration mechanism installed in the middle of the inner side of the right support plate 82, such as... Figure 8 As shown, both the left and right vibration mechanisms include a cylinder IV 841, a guide cylinder 842 with one open end, a vibration spring 843, a vibration clamping plate 844, and a dialyzer vibration motor 845. A cylinder IV mounting hole 846 is provided in the middle of both the left support plate 81 and the right support plate 82, as shown. Figure 9 and Figure 10As shown, the cylinder IV 841 on the left is fixedly installed in the cylinder IV mounting hole 846 of the left support plate 81, and the cylinder IV 841 on the right is fixedly installed in the cylinder IV mounting hole 846 of the right support plate 82. The piston rod of the cylinder IV 841 faces inward (that is, the piston rod of the cylinder IV 841 faces the middle between the left support plate 81 and the right support plate 82). The guide cylinder 842 is fixedly connected to the piston rod of the cylinder IV 841. One end of the vibration spring 843 is fixedly connected to the inner end wall of the guide cylinder 842, and the other end of the vibration spring 843 extends out of the open end of the guide cylinder 842 and is fixedly connected to the vibration clamping plate 844. The outer diameter of the guide cylinder 842 is smaller than the inner diameter of the mounting hole 846 of the cylinder IV. The vibration clamping plate 844 is an arc-shaped plate. The concave arc surfaces of the left vibration clamping plate 844 and the right vibration clamping plate 844 correspond to each other. The left vibration clamping plate 844 and the right vibration clamping plate 844 are used to clamp the dialyzer 11 during vibration. The left dialyzer vibration motor 845 is installed at the bottom left side of the left vibration clamping plate 844, and the right dialyzer vibration motor 845 is installed at the top right side of the right vibration clamping plate 844. When the dialyzer 11 is placed between the left support plate 81 and the right support plate 82, the piston rods of the cylinders IV 841 on the left and right support plates 81 and 82 extend, driving the guide cylinder 842 to move towards the center. This drives the vibration spring 843 and the vibration clamping plate 844 to approach the dialyzer 11 together. The vibration clamping plates 844 on both sides press against and hold the dialyzer 11. At this time, the dialyzer vibration motors 845 on both sides are turned on. Simultaneously, the dialyzer support rotation motor 5 drives the dialyzer 11 to tilt. When the flushing fluid passes through the dialyzer 11, the dialyzer vibration motors 845 on the left support plate 81 and the right support plate 82 are at different heights. With the coordinated action of the dialyzer support rotation motor 5 rotating and causing the dialyzer 11 to tilt, the dialyzer 11 moves in multiple dimensions. Driven by the pre-flushing fluid, the air and impurities attached to the inner wall of the dialyzer 11 and the fibers inside the dialyzer 11 can be quickly removed and discharged. Moreover, after the dialyzer 11 is tilted, it is also convenient for the gas and impurities attached to the top of the dialyzer 11 to be discharged through the venous end or arterial end.

[0046] Clamping mechanisms 83 are installed on the inner side of the left support plate 81 near the top and bottom sides, and on the inner side of the right support plate 82 near the top and bottom sides. Each clamping mechanism 83 includes a clamping cylinder V 831 and a clamping plate 832. Figure 8 As shown. Cylinder V mounting holes 833 are provided on the inner side of the left support plate 81 near the top and bottom sides, and on the inner side of the right support plate 82 near the top and bottom sides, as shown. Figure 9 and Figure 10As shown, each cylinder V mounting hole 833 has a clamping cylinder V 831 installed inside it. The piston rod of the clamping cylinder V 831 faces inward (i.e., the middle part between the left support plate 81 and the right support plate 82). The piston rod of the clamping cylinder V 831 is fixedly connected to a clamping plate 832. The clamping plate 832 is an arc-shaped plate. The clamping plate 832 on the inner side of the left support plate 81 near the upper side and the clamping plate 832 on the inner side of the right support plate 82 near the upper side form a set of dialyzer clamping plates. The clamping plate 832 on the inner side of the left support plate 81 near the lower side and the clamping plate 832 on the inner side of the right support plate 82 near the lower side form another set of dialyzer clamping plates. Before pre-flushing begins, when the dialyzer 11 needs to be flipped or tilted, the piston rods of the clamping cylinders V 831 on the left support plate 81 and right support plate 82 extend, driving the clamping plates 832 on both sides to approach and clamp the dialyzer 11. The dialyzer 11 is held more stably by these two sets of clamping plates. During formal dialysis, the dialyzer 11 is also held by these two sets of clamping plates.

[0047] The rear ends of the left support plate 81 and the right support plate 82 are hinged to each other by a positioning and rotating mechanism, which includes a positioning shaft 85 and a torque spring 86, as shown below. Figure 11 As shown. The rear end of the left support plate 81 has at least two inner grooves 87 near its inner side, and the rear end of the right support plate 82 has an equal number of outwardly protruding rotating arms 88 that cooperate with each other. In this embodiment, there are two inner grooves 87 and two outwardly protruding rotating arms 88. Both the rear end of the left support plate 81 and the outwardly protruding rotating arms 88 have through holes I 89. The outwardly protruding rotating arms 88 on the rear end of the right support plate 82 are located within the corresponding inner grooves 87 on the rear end of the left support plate 81. A positioning shaft 85 passes through the through holes I 89 on the rear end of the left support plate 81 and the outwardly protruding rotating arms 88. A torque spring 86 is fitted onto the positioning shaft 85 within each inner groove 87 and at both ends of the corresponding outwardly protruding rotating arm 88. One end of the torque spring 86 is fixedly connected to the side wall of the corresponding inner groove 87, and the other end is fixedly connected to the corresponding outwardly protruding rotating arm 88. When the torque spring 86 is in its natural state, the snap-fit ​​ends of the left support plate 81 and the right support plate 82 are close to each other. When the dialyzer 11 is installed on the dialyzer holder 8, the dialyzer 11 presses against the snap-fit ​​ends of the left support plate 81 and the right support plate 82. After the snap-fit ​​end on the right side is compressed, the right support plate 82 rotates to the right rear side around the positioning shaft 85, and the torque spring 86 deforms. After the dialyzer 11 is placed between the left support plate 81 and the right support plate 82, under the restoring force of the torque spring 86, the left support plate 81 and the right support plate 82 are driven to approach the dialyzer 11, and the clamping mechanism 83 or the vibration mechanism 84 clamps the dialyzer 11.

[0048] The inner sides of the left clamping plate 67, right clamping plate 75, vibrating clamping plate 844, and clamping plate 832 are all provided with rubber pads 90. Each rubber pad 90 has a pressure sensor 91 and an tilt sensor 92 installed on its inner side. Figure 12 As shown. When the perfusion device 10 is held by the left clamp 67 and the right clamp 75, and the dialyzer 11 is held by the clamping plate 832 or the vibrating clamp 844, the pressure sensor 91 can monitor the clamping force to prevent excessive clamping force from damaging the perfusion device 10 and the dialyzer 11, and to prevent the perfusion device 10 from slipping out of the left clamp 67 and the right clamp 75, and the dialyzer 11 from slipping out of the two vibrating clamps 844 or the two clamping plates 832. The tilt sensor 92 can monitor the tilt angle of the perfusion device 10 and the dialyzer 11 to tilt them to the optimal position, which facilitates the further upward movement and discharge of gas and impurities attached to the top of the perfusion device 10 and the dialyzer 11, and also ensures that the venous or arterial ends of the perfusion device 10 and the dialyzer 11 are in the optimal position for discharge.

[0049] A dialysis machine combining hemoperfusion and hemodialysis includes a dialysis machine body 12 and the aforementioned hemoperfusion device support device, such as... Figure 13 As shown. A rectangular snap-fit ​​hole 13 is provided on the front side and near the right side of the dialysis machine body 12, as... Figure 14 As shown, each surface of the inner wall of the snap-fit ​​hole 13 is provided with a mounting hole 14 corresponding to the snap-fit ​​groove 103. The mounting hole 14 consists of a small-diameter circular hole segment I near the inner side and a large-diameter circular hole segment II near the outer side. A locking mechanism 15 is installed in each mounting hole 14, such as... Figure 15 As shown. The locking mechanism 15 includes cylinder VI 151, a fixing plate 152, a guide locking sleeve 153, a locking pin 154, a locking spring 155, and a locking pull rope 156, as follows. Figure 16As shown, cylinder VI 151 is installed inside circular hole section I. Fixing plate 152 is inserted into circular hole section II and rests against the step formed between circular hole section I and circular hole section II. A guide hole is provided in the middle of fixing plate 152. Guide locking sleeve 153 passes through the guide hole and slides within the guide hole wall. Locking pin 154 is disposed in circular hole section II and slides within the inner wall of circular hole section II. The inner end of locking pin 154 is fixedly connected to the outer end of guide locking sleeve 153. The piston rod of cylinder VI 151 extends towards the guide locking sleeve. The inner end of sleeve 153 is fitted with a locking spring 155, which is located between the locking pin 154 and the fixing plate 152. One end of the locking spring 155 is fixed to the inner end of the locking pin 154, and the other end is fixed to the fixing plate 152. The locking rope 156 passes through the guide locking sleeve 153, with one end fixedly connected to the inner end of the locking pin 154 and the other end fixedly connected to the piston rod of cylinder VI 151. The snap-in section 101 is inserted into the snap-in hole 13, and the outer end of the locking pin 154 is inserted into the corresponding snap-in groove 103. Figure 15 As shown. Cylinder VI 151 is controlled by a controller inside the dialysis machine body 12. Before dialysis pre-flushing, the hemoperfusion device support needs to be installed on the dialysis machine body 12. The controller in the dialysis machine body 12 controls the piston rod of cylinder VI 151 to retract, and the locking pin 154 is pulled into the mounting hole 14 by the locking rope 156. The guide locking sleeve 153 slides towards the side of cylinder VI 151, and the locking spring 155 is compressed. Then, the snap-in section 101 of the mounting base 1 is inserted into the snap-in hole 13. After insertion, the controller controls the piston rod of cylinder VI 151 to extend, and the locking rope 156 is released. At the same time, under the restoring force of the locking spring 155, the locking spring 155 drives the locking pin 154 to move outward in the mounting hole 14 and insert into the corresponding slot 103, thereby installing the hemoperfusion device support on the dialysis machine body 12.

[0050] Pressure sensor 91 and tilt sensor 92 are both electrically connected to the controller inside the dialysis machine body 12. Right telescopic cylinder I2, perfusion support rotation motor 4, dialyzer support rotation motor 5, left cylinder II 63, right cylinder III 71, perfusion left vibration motor 69, perfusion right vibration motor 77, cylinder IV 841, dialyzer vibration motor 845, clamping cylinder V 831 and cylinder VI 151 are all controlled by the controller inside the dialysis machine body 12.

[0051] A base 16 is located near the lower part of the right side wall of the dialysis machine body 12, and a support arm 17 is located near the upper part of the right side wall of the dialysis machine body 12. The base 16 has an insertion port, and the support arm 17 has a through hole II. The support rod 18 of the infusion stand passes through the through hole II on the support arm 17, and the bottom of the support rod 18 is inserted into the insertion port on the base 16. Figure 13 and Figure 17As shown. The distance between the support center formed by the left support plate 81 and the right support plate 82 and the support rod 18 is greater than half the length of the dialyzer 11. This can prevent the ends of the perfusion device 10 and the dialyzer 11 from contacting the support rod 18 and affecting their rotation when the perfusion device support rotation motor 4 drives the perfusion device 10 to rotate and the dialyzer support rotation motor 5 drives the dialyzer 11 to rotate. The piston rod of the right telescopic cylinder I2, the power output shafts of the perfusion support rotating motor 4 and the dialyzer support rotating motor 5 all face the right side of the dialyzer body 12. After the piston rod of the right telescopic cylinder I2 extends, it can drive the entire L-shaped support 3, the perfusion support rotating motor 4, the dialyzer support rotating motor 5, the perfusion support 6 and the dialyzer support 8 to be located on the right side of the dialyzer body 12. This arrangement is conducive to the rotation or tilting of the L-shaped support 3, the perfusion support rotating motor 4, the dialyzer support rotating motor 5, the perfusion support 6, the dialyzer support 8, the perfusion device 10 clamped between the left clamping plate 67 and the right clamping plate 75, and the dialyzer 11 clamped between the two left and right clamping plates 832 or the two left and right vibrating clamping plates 844. It also ensures that the connector on the dialyzer 11 that connects to the bypass pipeline is always located on the right side of the dialyzer 11, which is convenient for connecting to the bypass pipeline.

[0052] The left spring 66, right spring 74, and vibration spring 843 are all hollow springs. After passing through the hollow cavity of the left spring 66, one end of the power cord connects to the power source inside the dialysis machine body 12, and the other end connects to the left vibration motor 69 of the perfusion unit. Similarly, after passing through the hollow cavity of the right spring 74, one end of the power cord connects to the power source inside the dialysis machine body 12, and the other end connects to the right vibration motor 77 of the perfusion unit. The power cord passes through the hollow cavity of the vibration spring 843, with one end connected to the power source inside the dialysis machine body 12 and the other end connected to the corresponding dialyzer vibration motor 845. The hollow structure of the left spring 66, right spring 74, and vibration spring 843 ensures that the corresponding power cords are housed within these hollow structures, preventing the power cords from being exposed and affecting the clamping and vibration of the perfusion unit 10 and dialyzer 11.

[0053] When using this hemoperfusion combined with hemodialysis dialysis machine, before starting dialysis, the hemoperfusion support device needs to be installed on the dialysis machine body 12. The controller controls the piston rod of the right telescopic cylinder I2 to extend to the right side of the dialysis machine body 12, driving the L-shaped bracket 3, the hemoperfusion bracket rotation motor 4, the dialyzer bracket rotation motor 5, the hemoperfusion bracket 6, and the dialyzer bracket 8 to move to the right together, so that the hemoperfusion bracket 6 and the dialyzer bracket 8 are outside the right side of the dialysis machine body 12; then the dialyzer 11 and the hemoperfusion bracket 10 are installed on the hemoperfusion support device, as follows:

[0054] Dialyzer 11 Installation: Insert dialyzer 11 between the left support plate 81 and the right support plate 82, ensuring the bypass interface end of dialyzer 11 faces right, aligning with the bypass line on the right side wall of the dialyzer body 12 for easy connection. The controller controls the piston rod of clamping cylinder V 831 to extend, causing clamping plate 832 to approach the dialyzer body 12. This presses the rubber pads 90 on the inner sides of the clamping plates 832 against the left and right sides of dialyzer 11. The dialyzer 11 is held by the two sets of upper and lower dialyzer clamping plates. The pressure sensors on the rubber pads 90 on the inner sides of the clamping plates 832... The device 91 detects the clamping force of the clamping plate 832 on the dialyzer 11, and can control the magnitude of the clamping force. Then, the venous tubing is connected to the venous end of the dialyzer 11. After the venous end of the dialyzer 11 is connected, the controller controls the dialyzer support rotation motor 5 to rotate, causing the dialyzer 11 to flip. The venous end of the dialyzer 11 flips forward until the venous end of the dialyzer 11 is at the bottom of the dialyzer 11. Then, the arterial tubing is connected to the arterial end of the dialyzer 11. Then, the dialyzer support rotation motor 5 drives the dialyzer 11 to rotate back, so that the venous end of the dialyzer 11 returns to the top.

[0055] Installation of the perfusion device 10: Place the perfusion device 10 between the left clamp 67 and the right clamp 75. The piston rods of the left cylinder II 63 and the right cylinder III 71 extend. The extension of the piston rod of the left cylinder II 63 drives the left sliding sleeve 65 to press the left clamp 67 onto the left side of the perfusion device 10. The extension of the piston rod of the right cylinder III 71 drives the right sliding sleeve 73 to press the right clamp 75 onto the right side of the perfusion device 10. With the venous end of the perfusion device 10 facing upward, connect the venous tubing to the venous end of the perfusion device 10. After the venous end of the perfusion device 10 is connected, the controller controls the perfusion device support rotation motor 4 to rotate, driving the perfusion device 10 to rotate until the arterial end of the perfusion device 10 is in a position that is easy to install. Then connect the arterial tubing to the arterial end of the perfusion device 10. Then, the perfusion device 10 is rotated by the perfusion device support rotation motor 4, so that the venous end of the perfusion device 10 returns to the top.

[0056] Begin pre-flushing, venting, and impurity removal of the perfusion device 10 and dialyzer 11:

[0057] Pre-flushing of the irrigation device 10: The piston rods of the left cylinder II 63 and the right cylinder III 71 retract a short distance, causing the left sliding sleeve 65 to leave the left clamping plate 67 and the right sliding sleeve 73 to leave the right clamping plate 75. The left pull rope 68 and the right pull rope 76 are in a relaxed state. The left clamping plate 67 presses the left side of the irrigation device 10 with the driving force of the left spring 66, and the right clamping plate 75 presses the right side of the irrigation device 10 with the driving force of the right spring 74. The irrigation device 10 is suspended on the U-shaped frame 61 by the left spring 66 and the right spring 74. Turn on the left vibration motor 69 and the right vibration motor 77 of the perfusion device. With the injection of pre-flushing liquid, and the drive of the rotating motor 5 of the perfusion device support to tilt the perfusion device support 6 forward or backward, the perfusion device 10 is subjected to multi-dimensional vibration. This causes the gas inside the perfusion device 10, including the gas and impurities between the solid adsorbents, on the solid adsorbents, and on the inner wall of the perfusion device 10, to move upward in multiple dimensions and be discharged from the top of the perfusion device 10. This can achieve efficient and complete discharge of all gas and impurities inside the perfusion device 10 in a short time.

[0058] Pre-flushing of dialyzer 11: The controller controls the piston rod of cylinder IV 841 to extend, and the piston rod drives the guide cylinder 842 to move towards the center, thereby driving the vibration spring 843 and the vibration clamping plate 844 to move closer together. The rubber pads 90 on the inner side of the left and right vibration clamping plates 844 press on the left and right sides of dialyzer 11 and clamp dialyzer 11. At this time, the controller controls the piston rod of clamping cylinder V 831 to retract, driving the clamping plate 832 and the rubber pads 90 on its inner side away from dialyzer 11, releasing the clamping mechanism 83 from the constraint of dialyzer 11. The vibrating motors 845 on both sides of the dialyzer are turned on. Simultaneously, the dialyzer support rotation motor 5 drives the dialyzer 11 to tilt. The tilt angle of the dialyzer 11 is detected by the tilt sensor 92 on the rubber pad 90 inside the vibrating clamp 844, facilitating precise control of the dialyzer 11's tilt angle. When the pre-flushing fluid passes through the dialyzer 11, the vibrating motors 845 on the left support plate 81 and right support plate 82 are at opposite heights. Combined with the tilting effect of the dialyzer support rotation motor 5, this causes the dialyzer 11 to undergo multi-dimensional mixed motion. Under the influence of the pre-flushing fluid, the fluid adhering to the inner wall of the dialyzer 11 and the fibers within the dialyzer 11... Air and impurities can be quickly removed and discharged. When dialyzer 11 is tilted, it also facilitates the discharge of gas and impurities attached to the top of dialyzer 11 through the venous end. After the gas and impurities in the dialyzer 11 membrane are discharged, the bypass interface on dialyzer 11 is connected to the bypass line. The controller controls the dialyzer support rotation motor 5 to drive dialyzer 11 to rotate, so that the arterial end of dialyzer 11 is higher than the venous end. The bypass line is opened to flush the outside of dialyzer 11 membrane. At the same time, the two dialyzer vibration motors 845 are turned on, and the dialyzer support rotation motor 5 drives dialyzer 11 to swing up and down slightly, which can quickly remove the gas and impurities outside the dialyzer 11 membrane.

[0059] This hemoperfusion combined with hemodialysis dialysis machine automatically rotates the perfusion unit 10 and dialyzer 11, automatically tilts the perfusion unit 10 and dialyzer 11, and automatically vibrates the perfusion unit 10 and dialyzer 11. This enables automatic air and impurity removal from the perfusion unit 10 and dialyzer 11, eliminating the need for manual operation. Medical personnel only need to connect the venous end, arterial end, and bypass interface, significantly reducing manual operation and the chance of contact with the instruments. This also lowers the risk of infection from subsequent manual connection of arterial and venous puncture needles. Simultaneously, through automatic control, the perfusion unit 10 and dialyzer 11 can be pre-flushed and purged of air and impurities, saving time and preventing embolism risks caused by improper operation by medical personnel, which could lead to incomplete removal of impurities and gases from the perfusion unit 10 and dialyzer membrane. This greatly reduces reliance on medical personnel and ensures better pre-flushing of the perfusion unit 10 and the dialyzer membrane to remove gases and impurities.

[0060] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A blood perfusion device support apparatus, characterized by: The application relates to a dialysis machine, which comprises a mounting base (1), a right telescopic cylinder I (2), an L-shaped support (3), a perfusion device support rotating motor (4), a dialyzer support rotating motor (5), a perfusion device support (6) and a dialyzer support (8); the right telescopic cylinder I (2) is fixedly connected to the mounting base (1), the piston rod of the right telescopic cylinder I (2) horizontally extends to the right side, the L-shaped support (3) is fixedly connected to the piston rod of the right telescopic cylinder I (2), the dialyzer support rotating motor (5) is fixedly installed on the top of the L-shaped support (3), the power output shaft of the dialyzer support rotating motor (5) extends to the right side, the dialyzer support (8) is installed on the power output shaft of the dialyzer support rotating motor (5), the bottom of the L-shaped support (3) extends to the right side from below the dialyzer support (8), the perfusion device support rotating motor (4) is fixedly installed on the bottom right end of the L-shaped support (3), the power output shaft of the perfusion device support rotating motor (4) extends to the right side, and the perfusion device support (6) is installed on the power output shaft of the perfusion device support rotating motor (4). The perfusion device support (6) comprises a U-shaped frame (61), a perfusion device left support frame and a perfusion device right support frame; the left middle part of the U-shaped frame (61) is fixedly connected with the power output shaft of the perfusion device support rotating motor (4), the perfusion device left support frame is installed on the left top end of the U-shaped frame (61), the perfusion device right support frame is installed on the right top end of the U-shaped frame (61), and the perfusion device left support frame and the perfusion device right support frame are symmetrically arranged on the U-shaped frame (61). The perfusion device left support frame comprises a left guide sleeve (62), a left cylinder II (63), a left guide plate (64), a left sliding sleeve (65), a left spring (66), a left clamping plate (67), a left pull rope (68) and a perfusion device left vibrating motor (69); the left guide sleeve (62) is fixed on the left top end of the U-shaped frame (61), the open end of the left guide sleeve (62) faces right, the left cylinder II (63) is installed on the left side in the left guide sleeve (62), the left guide plate (64) is fixedly arranged on the cross section in the left guide sleeve (62), the left sliding sleeve (65) passes through the through hole arranged in the middle part of the left guide plate (64) and is in sliding fit with the left guide plate (64), the left end of the left sliding sleeve (65) is fixedly connected with the piston rod of the left cylinder II (63), the left spring (66) is sleeved on the left sliding sleeve (65), the left end of the left spring (66) is fixed on the left guide plate (64), the right end of the left spring (66) extends out of the right end of the left guide sleeve (62) and is fixedly connected with the left clamping plate (67), the left pull rope (68) passes through the left sliding sleeve (65), the left end of the left pull rope (68) is fixedly connected with the piston rod of the left cylinder II (63), the right end of the left pull rope (68) is fixedly connected with the left side of the left clamping plate (67), and the perfusion device left vibrating motor (69) is fixedly installed on the left side of the left clamping plate (67) close to the bottom or close to the top.

2. The cartridge support device of claim 1, wherein: The right support frame of the perfusion device comprises a right guide sleeve (70), a right cylinder III (71), a right guide plate (72), a right sliding sleeve (73), a right spring (74), a right clamping plate (75), a right pull rope (76) and a right vibration motor (77) of the perfusion device; the right guide sleeve (70) is fixed on the right top end of the U-shaped frame (61), the open end of the right guide sleeve (70) faces left, the right cylinder III (71) is installed on the right side in the right guide sleeve (70), the right guide plate (72) is fixedly arranged on the cross section in the right guide sleeve (70), the right sliding sleeve (73) passes through the through hole arranged in the middle of the right guide plate (72) and is in sliding fit with the right guide plate (72), the right end of the right sliding sleeve (73) is fixedly connected with the piston rod of the right cylinder III (71), the right spring (74) is sleeved on the right sliding sleeve (73), the right end of the right spring (74) is fixed on the right guide plate (72), the left end of the right spring (74) extends out of the left end of the right guide sleeve (70) and is fixedly connected with the right clamping plate (75), the right pull rope (76) passes through the right sliding sleeve (73), the right end of the right pull rope (76) is fixedly connected with the piston rod of the right cylinder III (71), the left end of the right pull rope (76) is fixedly connected with the right side of the right clamping plate (75), and the right vibration motor (77) of the perfusion device is fixedly installed on the right side of the right clamping plate (75) close to the bottom or close to the top; the left clamping plate (67) and the right clamping plate (75) are both arc-shaped plates, and the inner concave arc-shaped surfaces of the left clamping plate (67) and the right clamping plate (75) correspond to each other.

3. The cartridge support device of claim 2, wherein: The right end of the left sliding sleeve (65) is provided with an inner concave arc-shaped end (78) abutting against the left side outer wall of the left clamping plate (67), and the left end of the right sliding sleeve (73) is provided with an inner concave arc-shaped end (78) abutting against the right side outer wall of the right clamping plate (75); a semicircular frame (611) bent rearward is arranged on the bottom of the U-shaped frame (61) close to the middle.

4. The cartridge support device of claim 3, wherein: The dialyzer support (8) comprises a left support plate (81) and a right support plate (82); the left support plate (81) and the right support plate (82) are both arc-shaped plates, the inner concave arc-shaped surfaces of the left support plate (81) and the right support plate (82) correspond to each other, the rear ends of the left support plate (81) and the right support plate (82) are hingedly connected to each other, the front ends of the left support plate (81) and the right support plate (82) form a clamping end of the dialyzer (11), and the power output shaft of the dialyzer support rotating motor (5) is fixedly connected to the left side surface of the left support plate (81); the left support plate (81) and the right support plate (82) are provided with a clamping mechanism (83) capable of clamping the dialyzer (11) and a vibration mechanism (84) capable of vibrating the dialyzer (11).

5. The cartridge support device of claim 4, wherein: The vibration mechanism (84) includes a left vibration mechanism installed in the middle of the inner side of the left support plate (81) and a right vibration mechanism installed in the middle of the inner side of the right support plate (82), both of which include a cylinder IV (841), a guide cylinder (842) with one end open, a vibration spring (843), a vibration clamping plate (844) and a dialyzer vibration motor (845), the middle of the left support plate (81) and the middle of the right support plate (82) are provided with a cylinder IV mounting hole (846), the left cylinder IV (841) is fixedly installed in the cylinder IV mounting hole (846) of the left support plate (81), and the right cylinder IV (841) is fixedly installed in the cylinder IV mounting hole (846) of the right support plate (82), the piston rod of the cylinder IV (841) faces inward, the guide cylinder (842) is fixedly connected to the piston rod of the cylinder IV (841), one end of the vibration spring (843) is fixedly connected to the inner side end wall of the guide cylinder (842), the other end of the vibration spring (843) extends out of the open end of the guide cylinder (842) and is fixedly connected with the vibration clamping plate (844), the outer diameter of the guide cylinder (842) is smaller than the inner diameter of the cylinder IV mounting hole (846), the vibration clamping plate (844) is an arc plate, the inner concave arc surfaces of the left vibration clamping plate (844) and the right vibration clamping plate (844) correspond, and the left vibration clamping plate (844) and the right vibration clamping plate (844) are used to clamp the dialyzer (11) when vibrating, the left dialyzer vibration motor (845) is installed on the left side bottom of the left vibration clamping plate (844), and the right dialyzer vibration motor (845) is installed on the right side top of the right vibration clamping plate (844).

6. The cartridge support device of claim 5, wherein: The inner side of the left support plate (81) near the upper and lower sides and the inner side of the right support plate (82) near the upper and lower sides are provided with clamping mechanisms (83), the clamping mechanisms (83) include clamping cylinders V (831) and clamping plates (832), the inner side of the left support plate (81) near the upper and lower sides and the inner side of the right support plate (82) near the upper and lower sides are provided with cylinder V mounting holes (833), one clamping cylinder V (831) is installed in each cylinder V mounting hole (833), the piston rod of the clamping cylinder V (831) faces inward, and the piston rod of the clamping cylinder V (831) is fixedly connected with a clamping plate (832), the clamping plate (832) is an arc plate, the clamping plate (832) near the upper side of the inner side of the left support plate (81) and the clamping plate (832) near the upper side of the inner side of the right support plate (82) form a set of dialyzer clamping plates, and the clamping plate (832) near the lower side of the inner side of the left support plate (81) and the clamping plate (832) near the lower side of the inner side of the right support plate (82) form another set of dialyzer clamping plates.

7. The cartridge support device of claim 6, wherein: The rear ends of the left support plate (81) and the right support plate (82) are hingedly connected to each other through a positioning rotating mechanism, the positioning rotating mechanism comprises a positioning shaft (85) and a torque spring (86), the rear end of the left support plate (81) is provided with at least two inner grooves (87) near the inner side, the rear end of the right support plate (82) is provided with outer convex rotating arms (88) equal in number to the inner grooves (87) and matched with each other near the inner side, the rear end of the left support plate (81) and the outer convex rotating arms (88) are both provided with through holes I (89), the outer convex rotating arms (88) on the rear end of the right support plate (82) are located in the inner grooves (87) on the rear end of the left support plate (81), the positioning shaft (85) passes through the through holes I (89) on the rear end of the left support plate (81) and the through holes I (89) on the outer convex rotating arms (88), the positioning shaft (85) in each inner groove (87) and located at both ends of the corresponding outer convex rotating arm (88) is sleeved with a torque spring (86), one end of the torque spring (86) is fixedly connected to the side wall of the corresponding inner groove (87), the other end of the torque spring (86) is fixedly connected to the corresponding outer convex rotating arm (88), when the torque spring (86) is in a natural state, the clamping-in ends of the front ends of the left support plate (81) and the right support plate (82) are close to each other.

8. The cartridge support device of claim 7, wherein: The inner sides of the left clamping plate (67), the right clamping plate (75), the vibrating clamping plate (844) and the clamping plate (832) are all provided with rubber pads (90), the inner side surfaces of each rubber pad (90) are both mounted with a pressure sensor (91) and an inclination sensor (92).

9. A dialysis machine for hemoperfusion combined with hemodialysis, comprising a dialysis machine body (12), characterized in that: The blood perfusion device support device of claim 8, wherein the mounting base (1) comprises a clamping section (101) and an external section (102), the clamping section (101) has a rectangular cross section, and four clamping grooves (103) are arranged on the four surfaces of the clamping section (101); a clamping hole (13) with a rectangular cross section is arranged on the front side of the dialysis machine body (12) and close to the right side, each surface of the inner wall of the clamping hole (13) is provided with a mounting hole (14) corresponding to the clamping groove (103), the mounting hole (14) is composed of a small-diameter circular hole section I close to the inner side and a large-diameter circular hole section II close to the outer side, and a locking mechanism (15) is arranged in each mounting hole (14); the locking mechanism (15) comprises a gas cylinder VI (151), a fixed plate (152), a guide locking sleeve (153), a locking pin (154), a locking spring (155) and a locking pull rope (156); the gas cylinder VI (151) is arranged in the circular hole section I, the fixed plate (152) is clamped in the circular hole section II and abuts against the step formed between the circular hole section I and the circular hole section II, a guide hole is arranged in the middle of the fixed plate (152), the guide locking sleeve (153) passes through the guide hole and is in sliding fit with the guide hole, the locking pin (154) is arranged in the circular hole section II and is in sliding fit with the inner wall of the circular hole section II, the inner side end of the locking pin (154) is fixedly connected with the outer end of the guide locking sleeve (153), the piston rod of the gas cylinder VI (151) extends to the inner end of the guide locking sleeve (153), the locking spring (155) is sleeved outside the guide locking sleeve (153) and located between the locking pin (154) and the fixed plate (152), one end of the locking spring (155) is fixed on the inner end of the locking pin (154), the other end of the locking spring (155) is fixed on the fixed plate (152), the locking pull rope (156) passes through the guide locking sleeve (153), one end of the locking pull rope (156) is fixedly connected with the inner end of the locking pin (154), and the other end of the locking pull rope (156) is fixedly connected with the piston rod of the gas cylinder VI (151); the clamping section (101) is inserted into the clamping hole (13), and the outer end of the locking pin (154) is inserted into the corresponding clamping groove (103).

10. The hemodialysis machine for hemoperfusion combined hemodialysis according to claim 9, characterized in that: The pressure sensor (91) and the inclination sensor (92) are electrically connected with the controller in the dialysis machine body (12), and the right telescopic cylinder I (2), the perfusion device support rotating motor (4), the dialyzer support rotating motor (5), the left cylinder II (63), the right cylinder III (71), the perfusion device left vibrating motor (69), the perfusion device right vibrating motor (77), the cylinder IV (841), the dialyzer vibrating motor (845), the clamping cylinder V (831) and the cylinder VI (151) are controlled by the controller in the dialysis machine body (12).

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