Intelligent regulation and control moisturizing mask based on traditional Chinese medicine nanotechnology and skin micro-ecological balance

Abstract

The invention discloses an intelligent regulation and control moisturizing mask based on a traditional Chinese medicine nanotechnology and skin micro-ecological balance, and belongs to the technical field of cosmetics. The intelligent regulation and control moisturizing mask is prepared from the following raw materials: a scutellaria baicalensis nano extract, a ginseng nano extract, a cortex dictamni nano extract, probiotic fermentation product filtrate, trehalose, nano hyaluronic acid, temperature sensing microcapsules, pH sensing microcapsules and auxiliary materials. The mask combines a traditional Chinese medicine nanotechnology, a probiotic fermentation product and an intelligent micro-capsule regulation and control technology, so that active ingredients can be intelligently released according to skin temperature and pH changes, and personalized skin care is realized. The components such as the scutellaria baicalensis nano extract, the ginseng nano extract, the cortex dictamni nano extract, the probiotic fermentation product filtrate, the trehalose and the nano hyaluronic acid in the mask are suitable for various skin types, and can remarkably improve the skin moisture content, improve the skin barrier function and balance the skin micro-ecology.

Description

Technical Field

[0001] The present invention relates to the field of cosmetic technology, and in particular to an intelligently regulated moisturizing facial mask based on traditional Chinese medicine nanotechnology and skin microecological balance. Background Art

[0002] The global facial mask market is moving towards a high-tech, multi-effects-in-one development direction. Traditional Chinese medicine has significant advantages in improving human immunity, anti-inflammation, anti-oxidation, and promoting metabolism. Especially in skin care, many Chinese herbal ingredients have been proven to have the effects of enhancing skin immunity, protecting skin barriers, and repairing damaged cells. Although traditional Chinese medicine masks are natural and mild, the stability and skin absorption rate of their active ingredients are relatively low, resulting in limited efficacy. In the prior art, nano-processing, intelligent microcapsule regulation, and the application of probiotic fermentation products have significant potential in improving the efficacy of facial masks. However, how to combine these technologies with Chinese herbal ingredients to achieve efficient absorption, intelligent release, and skin microecological balance regulation of Chinese herbal ingredients is an urgent problem to be solved in this field. Summary of the invention

[0003] The purpose of the present invention is to provide an intelligently regulated moisturizing facial mask based on traditional Chinese medicine nanotechnology and skin microecological balance, so as to solve the problems existing in the above-mentioned prior art.

[0004] To achieve the above object, the present invention provides the following solutions:

[0005] The invention provides an intelligent regulating moisturizing facial mask based on traditional Chinese medicine nanotechnology and skin microecological balance. The facial mask comprises the following raw materials, measured by mass percentage: 1-2% of scutellaria baicalensis nano extract, 0.5-1% of ginseng nano extract, 0.5-1% of white moss peel nano extract, 1-3% of probiotic fermentation product filtrate, 0.5-1% of trehalose, 0.1-0.3% of nano hyaluronic acid, 0.1-0.3% of temperature-sensitive microcapsule wall material, 0.1-0.2% of pH-sensitive microcapsule wall material and 0.5-2% of auxiliary materials, and the rest is solvent.

[0006] Optionally, the temperature-sensitive microcapsule wall material is one or more of poly(N-isopropylacrylamide), polyethylene glycol and polylactic acid.

[0007] The temperature-sensitive microcapsule wall material of the present invention can release active ingredients when encountering changes in skin temperature. Poly(N-isopropylacrylamide) (PNIPAm) is a typical thermosensitive polymer with a phase transition temperature of about 32°C, which is close to the temperature of human skin; below the phase transition temperature, PNIPAm is hydrophilic and can absorb moisture; above the phase transition temperature, PNIPAm is hydrophobic, releasing moisture and encapsulated active ingredients. Polyethylene glycol (PEG) is a water-soluble polymer whose melting point and phase transition temperature can be controlled by adjusting the molecular weight; PEG is solid at lower temperatures, and gradually becomes liquid as the temperature rises, releasing the encapsulated active ingredients. Polylactic acid (PLA) is a biodegradable polymer with good biocompatibility and mechanical properties; the glass transition temperature and melting point of PLA can be controlled by adjusting the molecular weight and copolymer ratio, so that it releases active ingredients at a specific temperature.

[0008] Optionally, the pH sensing microcapsule wall material is one or more of polyacrylic acid, polymethacrylic acid and polyvinyl alcohol.

[0009] The pH-sensitive microcapsule wall material of the present invention can adjust the release rate of ingredients according to the pH change of the skin. Polyacrylic acid (PAA) is a typical pH-sensitive polymer, and its carboxyl group will undergo ionization changes at different pH values; in an acidic environment, PAA is hydrophobic; in an alkaline environment, PAA is hydrophilic and can release the encapsulated active ingredients. Polymethacrylic acid (PMAA) is a pH-sensitive polymer, and its carboxyl group will undergo ionization changes at different pH values; similar to PAA, PMAA is hydrophobic in an acidic environment and hydrophilic in an alkaline environment, and can release the encapsulated active ingredients. Polyvinyl alcohol (PVA) is a water-soluble polymer, and its solubility and hydrophilicity can be controlled by adjusting the molecular weight and the degree of cross-linking; PVA will show different solubility and hydrophilicity at different pH values, thereby realizing the intelligent release of active ingredients.

[0010] Optionally, the auxiliary materials include one or more of preservatives, thickeners and emulsifiers.

[0011] The present invention also provides a method for preparing the above-mentioned intelligent control moisturizing facial mask, comprising the following steps:

[0012] (1) Scutellaria baicalensis, ginseng and Dictamni peel are respectively prepared by supercritical fluid extraction technology and nano-crushing technology to obtain Scutellaria baicalensis nano-extract, ginseng nano-extract and Dictamni peel nano-extract;

[0013] (2) using plant petals as a fermentation substrate, preparing a composite bacterial agent using yeast and Bifidobacterium adolescentis, and inoculating the composite bacterial agent into the fermentation substrate for fermentation; after the fermentation is completed, solid-liquid separation is performed to obtain a probiotic fermentation product filtrate;

[0014] (3) mixing the scutellaria baicalensis nano extract, the ginseng nano extract, the white moss peel nano extract, the probiotic fermentation product filtrate, trehalose and nano hyaluronic acid, and homogenizing to obtain a mixture 1;

[0015] (4) dissolving the temperature-sensitive microcapsule wall material and the pH-sensitive microcapsule wall material in a solvent, and adding the mixture 1 to obtain a mixture 2;

[0016] (5) After mixing the mixture 2 with auxiliary materials, the mixture is coated on a 3D biofiber membrane cloth to obtain the intelligent regulating moisturizing facial mask.

[0017] Supercritical fluid extraction combined with nano-crushing technology is used to prepare Chinese medicine ingredients such as Scutellaria baicalensis, Ginseng, and Dictamni into nano-scale particles to improve their bioavailability and skin permeability. The particle size of the nanoparticles is in the range of 50-100nm, which effectively improves the stability and absorption effect of Chinese medicine ingredients.

[0018] Through the microencapsulation process, temperature-sensing microcapsules and pH-sensing microcapsules are integrated with traditional Chinese medicine nano-ingredients and probiotic fermentation products to form an intelligent control system. Temperature-sensing microcapsules release active ingredients when encountering changes in skin temperature; pH-sensing microcapsules adjust the release rate of ingredients according to changes in the pH value of the skin, ensuring that nutrients are released when the skin needs them most.

[0019] Using 3D bio-fiber preparation technology, the prepared nano-Chinese medicine and microcapsule-encapsulated ingredients are evenly coated on the bio-fiber membrane cloth to form a mask cloth with high adsorption and fit, which can ensure the efficient delivery of active ingredients.

[0020] Furthermore, the fluid in the supercritical fluid extraction technology is carbon dioxide.

[0021] Furthermore, the particle sizes of the scutellaria baicalensis nano extract, the ginseng nano extract and the white moss peel nano extract are all 50-100 nm.

[0022] Furthermore, the ratio of the number of live bacteria of yeast and Bifidobacterium adolescentis in the composite bacterial agent is 1:1; and the inoculation amount of the composite bacterial agent is 3-5%.

[0023] Furthermore, the temperature during the fermentation is 35-40°C and the time is 70-80h.

[0024] Furthermore, the pressure during homogenization is 25-40 MPa, the temperature is 35-45° C., and the time is 8-12 min.

[0025] The present invention discloses the following technical effects:

[0026] The mask of the present invention achieves multiple skin care effects through the organic combination of traditional Chinese medicine nanotechnology, probiotic fermentation products and intelligent microcapsule regulation technology. Nano-sized traditional Chinese medicine ingredients enhance skin permeability and absorption efficiency; intelligent microcapsule regulation technology ensures that active ingredients can be intelligently released according to skin temperature and pH changes, ensuring optimal absorption under different skin conditions, providing personalized skin care effects and skin care experience; probiotic fermentation products and traditional Chinese medicine ingredients work synergistically to regulate skin microecology, enhance skin immunity, and maintain skin health; nano hyaluronic acid and trehalose provide deep moisturizing, strengthen skin water-locking ability, repair damaged skin barrier, and improve the overall skin condition. Experimental data show that the mask can significantly increase skin moisture content, improve skin barrier function, balance skin microecology, and is suitable for a variety of skin types. DETAILED DESCRIPTION

[0027] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0028] It should be understood that the terms described in the present invention are only for describing a particular embodiment and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. The intermediate value in any stated value or stated range, and each smaller range between any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0029] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0030] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to those skilled in the art. The present invention description and examples are exemplary only.

[0031] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0032] The raw material composition and dosage of the intelligently controlled moisturizing facial mask based on traditional Chinese medicine nanotechnology and skin microecological balance of the present invention are as follows, and the following raw materials are all in mass concentration:

[0033] Scutellaria baicalensis nano extract: 1-2%;

[0034] Ginseng nano extract: 0.5-1%;

[0035] Nano extract of white moss skin: 0.5-1%;

[0036] Probiotic fermentation product filtrate: 1-3%;

[0037] Trehalose: 0.5-1%;

[0038] Nano hyaluronic acid: 0.1-0.3%;

[0039] Temperature sensing microcapsules: 0.1-0.3%;

[0040] pH sensing microcapsules: 0.1-0.2%;

[0041] Excipients: 0.5-2%;

[0042] The rest is solvent.

[0043] In the present invention, the nano extract of scutellaria baicalensis, the nano extract of ginseng and the nano extract of white moss peel all adopt supercritical fluid extraction and nano pulverization technology to prepare, and the particle diameter of the extract is within the scope of 50-100nm, which is more conducive to skin absorption. The nano extract of scutellaria baicalensis has the effect of anti-oxidation, anti-inflammatory, repairing skin barrier. The nano extract of ginseng has the effect of promoting skin cell regeneration and enhancing skin immunity. The nano extract of white moss peel has antibacterial and anti-inflammatory effects, and helps regulate skin microecology.

[0044] In the present invention, the probiotic fermentation product filtrate is obtained by fermenting natural plants with probiotics, which can regulate the skin microecology, enhance the skin barrier function, and effectively improve the skin health. In the present invention, probiotics are acceptable probiotic species in the field of skin care products, for example, one or more of yeast, lactic acid bacteria and bacillus; in some embodiments of the present invention, the probiotics are selected from yeast and bifidobacterium adolescentis. There are no special requirements for the yeast and bifidobacterium adolescentis in the present invention, and both can be purchased through conventional channels.

[0045] In the present invention, trehalose has a deep water-locking effect, can maintain the water balance inside and outside the cells, and improve the water content of the skin.

[0046] In the present invention, the particle size of nano hyaluronic acid is less than 100 nm, which can penetrate into the deep layer of the skin, provide continuous moisturizing and enhance skin elasticity.

[0047] In the present invention, the wall material of the temperature-sensitive microcapsule is a temperature-sensitive raw material, for example, one or more of poly(N-isopropylacrylamide), polyethylene glycol and polylactic acid. The nano-ingredients of traditional Chinese medicine are encapsulated in the temperature-sensitive microcapsule, and the active ingredients are intelligently released according to the change of skin temperature to promote skin absorption. The particle size of the microcapsule is controlled at 200-300nm.

[0048] In the present invention, the pH sensing microcapsule wall material is a pH sensitive raw material, for example, one or more of polyacrylic acid, polymethacrylic acid and polyvinyl alcohol. The probiotic fermentation product and other active ingredients are encapsulated in the pH sensing microcapsule wall material to sense the pH value change on the skin surface, adjust the release rate, and maintain the balance of the skin microecology.

[0049] In the present invention, the auxiliary materials include one or more of preservatives, thickeners and emulsifiers; in some embodiments of the present invention, the auxiliary materials are preservatives, thickeners and emulsifiers in a mass ratio of (0.1-1): (2-5): (3-6); in other embodiments of the present invention, the auxiliary materials are preservatives, thickeners and emulsifiers in a mass ratio of 0.5:3:5.

[0050] In the present invention, the preservative is an acceptable preservative in the field of skin care products, for example: one or more of caprylhydroxamic acid / 1,2-hexanediol / 1,3-propylene glycol, phenoxyethanol, cinnamaldehyde, and 1,2-hexanediol; in some embodiments of the present invention, the preservative is selected from phenoxyethanol.

[0051] In the present invention, the thickener is an acceptable thickener in the field of skin care products, for example, one or more of carbomer, gum arabic, agar, and propylene glycol alginate; in some embodiments of the present invention, the thickener is selected from carbomer.

[0052] In the present invention, the emulsifier is an emulsifier acceptable in the field of skin care products, for example: one or more of polyvinyl alcohol-dodecyl ether, sodium alkylbenzene sulfonate, polydimethylsiloxane, Tween 80; in some embodiments of the present invention, the emulsifier is sodium alkylbenzene sulfonate.

[0053] In the present invention, the solvent is sterile water.

[0054] Example 1 Preparation of Chinese herbal medicine extract

[0055] 1. Pretreatment of Chinese medicine raw materials

[0056] The raw materials of scutellaria baicalensis, ginseng and white moss peel are screened to remove the raw materials that are moldy, deteriorated or do not meet the requirements. The scutellaria baicalensis, ginseng and white moss peel after screening are placed in an oven and dried at a temperature of 60 ℃ to a water content lower than 8% (reducing the moisture content in the raw materials to create favorable conditions for the subsequent extraction process). The dried scutellaria baicalensis, ginseng and white moss peel are crushed into 20 purpose Chinese medicine powders respectively (the crushed materials can be more fully contacted with the supercritical fluid, thereby improving the extraction efficiency). The crushed Chinese medicine powder is placed in an oven again and dried at a temperature of 50 ℃ for 12 hours. The dried Chinese medicine powder is naturally cooled to room temperature. By drying again, the moisture content in the raw materials can be further reduced to ensure the smooth progress of the extraction process.

[0057] 2. Supercritical fluid extraction

[0058] The pre-treated scutellaria powder, ginseng powder and white moss peel powder were subjected to supercritical fluid extraction respectively. The Chinese medicine powder was loaded into the barrel of the extractor, CO2 gas was injected into the extraction kettle, and the CO2 gas was made to reach a supercritical state by adjusting the temperature and pressure (supercritical CO2 fluid has the characteristics of density similar to liquid and viscosity similar to gas, high solubility for solute and easy diffusion). In the supercritical state, CO2 fluid is fully in contact with the Chinese medicine powder to dissolve the effective ingredients therein. During the extraction process, the temperature of the supercritical fluid was controlled to be 50°C, the pressure was 30MPa, the flow rate was 160kg / h, and the extraction time was 2h. After the extraction, a crude extract of Chinese medicine was obtained.

[0059] The crude extract of Chinese medicine is expanded from the extraction kettle to the separation kettle. The temperature is adjusted to 30°C and the pressure is adjusted to 5MPa, so that the Chinese medicine extract is separated from the CO2 gas and settled at the bottom of the separator, and the extract is collected to obtain the scutellaria baicalensis extract, ginseng extract and white moss peel extract.

[0060] 3. Nano-crushing treatment

[0061] The collected extracts are subjected to nano-crushing treatment using a jet mill to grind the particles to a particle size between 50 and 100 nm, and the nano-crushed extracts are freeze-dried to obtain scutellaria nano-extracts, ginseng nano-extracts and white moss peel nano-extracts.

[0062] Example 2 Preparation of probiotic fermentation product filtrate

[0063] 1. Preparation of fermentation substrate

[0064] Fresh rose petals and marigold petals are picked, cleaned, yellow and wrinkled parts are removed, 5 times the mass of water is added to form slurry, the slurry is passed through a 100-mesh sieve, and the sieve residue is collected to obtain a fermentation substrate.

[0065] 2. Preparation of composite bacterial agent

[0066] Yeast and Bifidobacterium adolescentis were dissolved in sterile water to prepare bacterial suspension. 10 μL of bacterial suspension was inoculated on PDA medium. After activation culture for 36 h, single colonies of Bifidobacterium adolescentis and yeast were picked and inoculated into MRS liquid medium for expansion culture to obtain a viable count of 6×10 6 CFU / mL of Bifidobacterium adolescentis bacterial solution and yeast bacterial solution. The Bifidobacterium adolescentis bacterial solution and the yeast bacterial solution are mixed in a volume ratio of 1:1 to obtain a composite bacterial solution.

[0067] 3. Preparation of probiotic fermentation product filtrate

[0068] The fermentation substrate was sterilized, and the composite bacterial solution was inoculated into the fermentation substrate at a ratio of 4% (v / v). After fermentation at 38°C for 72 hours, the temperature was raised to 95°C for sterilization for 30 minutes, followed by centrifugation at 8000 rpm for 5 minutes, and the supernatant was taken to obtain the probiotic fermentation product filtrate.

[0069] Example 3 Preparation of Intelligent Moisturizing Mask

[0070] 1. Weighing of raw materials

[0071] According to mass percentage, 1.5% of the scutellaria baicalensis nano extract prepared in Example 1, 1% of the ginseng nano extract prepared in Example 1, 1% of the white moss peel nano extract prepared in Example 1, 2% of the probiotic fermentation product filtrate prepared in Example 2, 0.8% trehalose, 0.2% nano hyaluronic acid, 0.2% temperature-sensitive microcapsule wall material (poly (N-isopropylacrylamide)), 0.1% pH-sensitive microcapsule wall material (polyacrylic acid), 1.5% excipients (mixed by phenoxyethanol, carbomer and sodium alkylbenzene sulfonate in a mass ratio of 0.5:3:5) and 91.7% of water were weighed.

[0072] 2. Preparation of mixture 1

[0073] The scutellaria baicalensis nano-extract, the ginseng nano-extract, the white moss peel nano-extract, the probiotic fermentation product filtrate, trehalose and the nano-hyaluronic acid were mixed and homogenized to obtain a mixture 1. The pressure during the homogenization process was set to 30 MPa, the temperature was 40° C., and the time was 10 min.

[0074] 3. Preparation of mixture 2

[0075] Dissolve the temperature-sensitive microcapsule wall material and the pH-sensitive microcapsule wall material in water, stir to dissolve, add mixture 1 and continue stirring until all the raw materials are blended together to form an intelligent controlled release system, which is mixture 2.

[0076] 4. Preparation of mixture 3

[0077] Mix mixture 2 and the auxiliary materials uniformly to obtain mixture 3.

[0078] 5. Preparation of facial mask

[0079] The mixture 3 is evenly coated on the 3D biofiber membrane cloth, and the mixture is packaged and sealed to obtain the intelligent regulating moisturizing mask.

[0080] Example 4 Preparation of Intelligent Moisturizing Mask

[0081] 1. Weighing of raw materials

[0082] According to mass percentage, 1% of the Scutellaria baicalensis nano extract prepared in Example 1, 1% of the ginseng nano extract prepared in Example 1, 1% of the white moss peel nano extract prepared in Example 1, 3% of the probiotic fermentation product filtrate prepared in Example 2, 0.5% trehalose, 0.1% nano hyaluronic acid, 0.3% of temperature-sensitive microcapsule wall material (polyethylene glycol), 0.2% of pH-sensitive microcapsule wall material (polymethacrylic acid), 2% of auxiliary materials (mixed by phenoxyethanol, carbomer and sodium alkylbenzene sulfonate in a mass ratio of 0.5:3:5) and 90.7% of water were weighed.

[0083] 2. Preparation of mixture 1

[0084] The scutellaria baicalensis nano-extract, the ginseng nano-extract, the white moss peel nano-extract, the probiotic fermentation product filtrate, trehalose and the nano-hyaluronic acid were mixed and homogenized to obtain a mixture 1. The pressure during the homogenization process was set to 30 MPa, the temperature was 40° C., and the time was 10 min.

[0085] 3. Preparation of mixture 2

[0086] Dissolve PNIPAm and pH-sensitive microcapsule wall material in water, stir to dissolve, add mixture 1 and continue stirring until all the raw materials are blended together to form an intelligent controlled release system, which is mixture 2.

[0087] 4. Preparation of mixture 3

[0088] Mix mixture 2 and the auxiliary materials uniformly to obtain mixture 3.

[0089] 5. Preparation of facial mask

[0090] The mixture 3 is evenly coated on the 3D biofiber membrane cloth, and the mixture is packaged and sealed to obtain the intelligent regulating moisturizing mask.

[0091] Example 5 Preparation of Intelligent Moisturizing Mask

[0092] 1. Weighing of raw materials

[0093] According to mass percentage, 2% of the scutellaria baicalensis nano extract prepared in Example 1, 0.5% of the ginseng nano extract prepared in Example 1, 0.5% of the white moss peel nano extract prepared in Example 1, 1% of the probiotic fermentation product filtrate prepared in Example 2, 1% trehalose, 0.3% nano hyaluronic acid, 0.1% temperature-sensitive microcapsule wall material (polylactic acid), 0.1% pH-sensitive microcapsule wall material (polyvinyl alcohol), 0.5% excipients (mixed by phenoxyethanol, carbomer and sodium alkylbenzene sulfonate in a mass ratio of 0.5:3:5) and 90.7% of water were weighed.

[0094] 2. Preparation of mixture 1

[0095] The scutellaria baicalensis nano-extract, the ginseng nano-extract, the white moss peel nano-extract, the probiotic fermentation product filtrate, trehalose and the nano-hyaluronic acid were mixed and homogenized to obtain a mixture 1. The pressure during the homogenization process was set to 30 MPa, the temperature was 40° C., and the time was 10 min.

[0096] 3. Preparation of mixture 2

[0097] Dissolve the temperature-sensitive microcapsule wall material and the pH-sensitive microcapsule wall material in water, stir to dissolve, add mixture 1 and continue stirring until all the raw materials are blended together to form an intelligent controlled release system, which is mixture 2.

[0098] 4. Preparation of mixture 3

[0099] Mix mixture 2 and the auxiliary materials uniformly to obtain mixture 3.

[0100] 5. Preparation of facial mask

[0101] The mixture 3 is evenly coated on the 3D biofiber membrane cloth, and the mixture is packaged and sealed to obtain the intelligent regulating moisturizing mask.

[0102] Comparative Example 1

[0103] The only difference from Example 3 is that the preparation methods of the scutellaria baicalensis nano extract, the ginseng nano extract and the white moss peel nano extract are adjusted to: ethanol reflux extraction and nano-crushing treatment.

[0104] In the ethanol reflux extraction process, the volume fraction of ethanol used was 80%, the mass ratio of ethanol to Chinese medicinal raw materials was 10:1, the reflux extraction temperature was 60°C, and the time was 2 hours. The process of nano-crushing treatment was the same as that of Example 1.

[0105] Comparative Example 2

[0106] The only difference from Example 3 is that Bifidobacterium adolescentis in the preparation process of the probiotic fermentation product filtrate is replaced by Lactobacillus rhamnosus.

[0107] Test Example 1 Safety Experiment

[0108] Experimental subjects: 10 volunteers aged 18 to 50 years old with no serious skin damage were selected.

[0109] Experimental method: 5 test areas with an area of ​​3 cm × 3 cm were selected on the left and right arms of each person. After cleaning, the masks of Examples 3-5 and Comparative Examples 1-2 were cut into the same size as the test areas and applied to the test areas twice a day. The skin reaction was observed after 24 hours and the test was continued for 7 days.

[0110] Experimental results: Within 7 days, the volunteers did not experience skin allergic reactions such as erythema, dry skin, wrinkles, edema, bullae, erosion, etc., and did not feel any irritation after application. This shows that the masks of Examples 3-5 and Comparative Examples 1-2 are safe and have no toxic side effects on human skin.

[0111] Test Example 2 Moisturizing Effect Test

[0112] Experimental subjects: 15 volunteers aged 18 to 50 with no serious skin damage were selected, with three people in each group.

[0113] Experimental method: let the volunteers calm down in an environment with a temperature of 25°C and a relative humidity of 45%. After each person cleans the facial skin, the moisture content of the facial skin before the experiment is tested. Take the facial masks of Examples 3-5 and Comparative Examples 1-2 respectively, and test one facial mask in each group, and use it for 10 minutes. Detect the moisture content of the facial skin after the experiment, and calculate the skin hydration change rate according to the following formula: Skin hydration change rate = (skin moisture content after the experiment - skin moisture content before the experiment) / skin moisture content before the experiment × 100%. The results are averaged.

[0114] Experimental results: The moisturizing performance test results of each group of masks are shown in Table 1.

[0115] Table 1 Moisturizing performance test results of each group of facial masks

[0116]

[0117]

[0118] As can be seen from Table 1, the facial masks of Examples 3-5 can significantly increase the moisture content of the skin. In contrast, after the preparation methods of the Chinese medicine extract and the preparation methods of the probiotic fermentation product filtrate were changed in Comparative Examples 1-2, the moisturizing and hydrating effect of the facial masks decreased.

[0119] Test Example 3 Skin barrier repair function test

[0120] Experimental subjects: 10 volunteers aged 18 to 50 were selected, with two people in each group.

[0121] Experimental method: After the skin barrier was damaged by tape stripping on the inner side of the forearm, the masks of Examples 3-5 and Comparative Examples 1-2 were applied respectively. One mask was tested in each group, and the use time was 10 minutes. Used once a day for 7 consecutive days. The repair rate of each mask on the skin barrier was evaluated by testing the transepidermal water loss rate before the experiment, on the 3rd day and the 7th day of the experiment. The smaller the value of the transepidermal water loss rate, the better the skin barrier. The average value of the measurement results was taken.

[0122] Experimental results: as shown in Table 2.

[0123] Table 2 Transepidermal water loss rate of each group

[0124] sample Before the experiment Experimental day 3 Experimental day 7 Example 3 33.12％ 27.23％ 24.65％ Example 4 29.54％ 25.45％ 23.91％ Example 5 30.20％ 25.88％ 24.11％ Comparative Example 1 31.78％ 29.69％ 27.64％ Comparative Example 2 31.61％ 29.14％ 26.73％

[0125] As can be seen from Table 2, the masks of Examples 3-5 and Comparative Examples 1-2 can reduce the transepidermal water loss rate of damaged skin. However, in comparison, the transepidermal water loss rate of damaged skin after use of the mask of Examples 3-5 is reduced to the greatest extent, and the skin barrier repair effect of the mask of Comparative Example 1-2 is reduced after the preparation method of the Chinese medicine extract and the preparation method of the probiotic fermentation product filtrate are changed.

[0126] in conclusion:

[0127] The present invention provides an intelligently regulated moisturizing mask based on traditional Chinese medicine nanotechnology and skin microecological balance, which achieves multiple skin care effects by combining traditional Chinese medicine nanotechnology, probiotic fermentation products and intelligent microcapsule regulation technology. The mask can significantly increase the water content of the skin, improve the skin barrier function, balance the skin microecology, and is suitable for a variety of skin types. Experimental data show that the mask of the present invention has significant effects in moisturizing, repairing the skin barrier, etc., and is superior to similar products in the prior art.

[0128] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. An intelligently controlled moisturizing facial mask based on traditional Chinese medicine nanotechnology and skin microecological balance, characterized in that: Calculated by mass percentage, the raw materials include: 1-2% scutellaria baicalensis nano extract, 0.5-1% ginseng nano extract, 0.5-1% white moss peel nano extract, 1-3% probiotic fermentation product filtrate, 0.5-1% trehalose, 0.1-0.3% nano hyaluronic acid, 0.1-0.3% temperature-sensitive microcapsule wall material, 0.1-0.2% pH-sensitive microcapsule wall material and 0.5-2% auxiliary materials, and the rest are solvents.

2. The intelligent regulating moisturizing mask according to claim 1, characterized in that: The wall material of the temperature-sensitive microcapsule is one or more of poly(N-isopropylacrylamide), polyethylene glycol and polylactic acid.

3. The intelligent regulating moisturizing mask according to claim 1, characterized in that: The pH sensing microcapsule wall material is one or more of polyacrylic acid, polymethacrylic acid and polyvinyl alcohol.

4. The intelligent regulating moisturizing mask according to claim 1, characterized in that: The auxiliary materials include one or more of preservatives, thickeners and emulsifiers.

5. A method for preparing the intelligently controlled moisturizing facial mask according to any one of claims 1 to 4, characterized in that: The steps include: (1) Scutellaria baicalensis, ginseng and Dictamni peel are respectively prepared by supercritical fluid extraction technology and nano-crushing technology to obtain Scutellaria baicalensis nano-extract, ginseng nano-extract and Dictamni peel nano-extract; (2) using plant petals as a fermentation substrate, preparing a composite bacterial agent using yeast and Bifidobacterium adolescentis, and inoculating the composite bacterial agent into the fermentation substrate for fermentation; after the fermentation is completed, solid-liquid separation is performed to obtain a probiotic fermentation product filtrate; (3) mixing the scutellaria baicalensis nano extract, the ginseng nano extract, the white moss peel nano extract, the probiotic fermentation product filtrate, trehalose and nano hyaluronic acid, and homogenizing to obtain a mixture 1; (4) dissolving the temperature-sensitive microcapsule wall material and the pH-sensitive microcapsule wall material in a solvent, and adding the mixture 1 to obtain a mixture 2; (5) After mixing the mixture 2 with auxiliary materials, the mixture is coated on a 3D biofiber membrane cloth to obtain the intelligent regulating moisturizing facial mask.

6. The preparation method according to claim 5, characterized in that: The fluid in the supercritical fluid extraction technology is carbon dioxide.

7. The preparation method according to claim 5, characterized in that: The particle sizes of the scutellaria baicalensis nano extract, the ginseng nano extract and the white moss peel nano extract are all 50-100 nm.

8. The preparation method according to claim 5, characterized in that: The ratio of the live bacteria counts of yeast and Bifidobacterium adolescentis in the composite bacterial agent is 1:1; and the inoculation amount of the composite bacterial agent is 3-5%.

9. The preparation method according to claim 5, characterized in that: The temperature during the fermentation is 35-40°C and the time is 70-80 hours.

10. The preparation method according to claim 5, characterized in that: The pressure during homogenization is 25-40 MPa, the temperature is 35-45° C., and the time is 8-12 min.

Images