Preparation method and device of musk Tongxin dropping pill

Abstract

The invention belongs to the field of biological pharmacy, and particularly discloses a preparation method of a musk heart-soothing dropping pill, which comprises the following steps: preparing salvia miltiorrhiza clear paste, uniformly stirring and mixing the salvia miltiorrhiza clear paste, artificial musk, ginseng stem and leaf total saponins, venenum bufonis, calculus bovis factitius, bear gall powder, borneol, polyethylene glycol 6000 and polysorbate 80, dripping, centrifuging, screening and drying, and coating to prepare the musk heart-soothing dropping pill. The invention has the advantages of obvious clinical curative effect, no side effect, high drug stability, quick dissolution, high efficiency and quick effect. The invention further discloses a preparation device of the musk Tongxin dropping pill, a vertical silica gel cleaning strip, a first silica gel cleaning strip and a second silica gel cleaning strip in the silica gel cleaning screen frame and the silica gel cleaning strip component are arranged in a crossed mode, the silica gel cleaning screen frame and the silica gel cleaning strip component can make friction contact with different surfaces of salvia miltiorrhiza in the cleaning process, and the comprehensive and meticulous cleaning effect is provided. By means of the design, the cleaning area is increased, fine dust and impurities on the surface of the radix salviae miltiorrhizae can be effectively removed, and dead corners prone to omission in a traditional cleaning mode are avoided.

Description

Technical Field

[0001] The invention belongs to the technical field of biopharmaceuticals, in particular to a method and a device for preparing Shexiang Tongxin Dropping Pills. Background Art

[0002] Coronary heart disease can also be called ischemic heart disease. It belongs to the category of medical "true heart pain", "collapse heart pain", "chest pain" and other diseases, and the symptoms of angina pectoris of coronary heart disease can spread to the whole body. Its causes are mostly due to excessive thinking, fatigue of the heart and spleen, improper diet, internal generation of phlegm and fluid, emotional depression, liver depression and yin injury, and kidney deficiency due to old age, which lead to weak heart yang and internal phlegm. Its symptoms are sudden chest pain, or chest tightness like heavy pressure, or chest angina as the main, accompanied by pain and numbness in the left shoulder and arm, chest tightness and shortness of breath, palpitations and shortness of breath, high blood lipids, abnormal electrocardiogram after rest or exercise, etc. Angina pectoris patients often last for 3 to 5 minutes, which can radiate to the left arm, shoulder, mandible, throat, back, and can also radiate to the right arm. The pain of patients with coronary heart disease lasts for a long time, often for several hours or even one or two days; the pain range is also wide, which can affect the left chest and even the upper abdomen. It may also be accompanied by symptoms such as shock, heart failure and arrhythmia.

[0003] At present, drug therapy is one of the commonly used methods for treating coronary heart disease and its related symptoms. Among them, Musk Tongxin Drop Pills is a Chinese patent medicine specially designed for the above symptoms. However, the existing technology still has certain defects in the drug production process. Especially in the cleaning link in the drug production process, the design of traditional cleaning equipment such as the cleaning tank is not perfect. Specifically, the drainage filter holes in the cleaning tank are prone to blockage, which not only affects the cleaning efficiency, but also may cause the drug residues to fail to be completely removed, thereby affecting the quality and safety of the drugs. When the drainage filter holes are blocked by impurities, the speed of water flowing through the drainage filter holes slows down, resulting in incomplete cleaning; at the same time, in order to overcome the increased resistance caused by the blockage, more energy is needed to maintain the same cleaning effect, which increases the production cost. In addition, frequent shutdowns to clean the filter holes will also reduce the overall efficiency of the production line and extend the production cycle. Therefore, how to effectively solve the problem of easy blockage of the cleaning tank filter holes and improve the cleaning efficiency and drug quality has become an important issue that needs to be solved in the pharmaceutical field.

[0004] After searching, the existing Chinese patent publication number: CN116851342A is a raw material processing device for dispelling cold and dampness and its process, including: a transportation track and a medicine washing trough, the transportation track is used to transport the raw materials to the medicine washing trough, rollers are rotatably provided in the medicine washing trough, a second cleaning plate is fixedly provided at the bottom of the medicine washing trough, a filter plate is provided above the second cleaning plate, the filter plate is hinged to the medicine washing trough at one end close to the transportation track, and also includes a first spring, the two ends of the first spring are respectively fixed to the other end of the filter plate and the inner wall of the medicine washing trough, when the filter plate is load-bearing, the first spring is used to control the filter plate to tilt toward the end away from the transportation track.

[0005] The patent documents cited above also have the same problem. The drainage filter holes in the cleaning tank are prone to clogging, which not only affects the cleaning efficiency, but may also result in the failure to completely remove the drug residues, thereby affecting the quality and safety of the drugs. When the drainage filter holes are blocked by impurities, the speed at which water flows through the drainage filter holes slows down, resulting in incomplete cleaning; at the same time, in order to overcome the increased resistance caused by the blockage, more energy is required to maintain the same cleaning effect, increasing production costs. Summary of the invention

[0006] The purpose of the present invention is to provide a method and device for preparing Shexiang Tongxin Dropping Pills to solve the problems raised in the background technology.

[0007] To achieve the above object, the present invention provides the following technical scheme: a preparation method of Musk Tongxin Dropping Pills, comprising the following steps: S1: the Musk Tongxin Dropping Pills are prepared by weighing the following components by weight: 18 to 20 parts of artificial musk, 30 to 40 parts of total saponins of ginseng stems and leaves, 100 to 120 parts of toad venom, 500 to 550 parts of salvia miltiorrhiza, 60 to 65 parts of artificial bezoar, 26 to 30 parts of bear bile powder, and 52 to 60 parts of borneol;

[0008] S2: Take a formula amount of Danshen, clean and select, wash, soak, cut and dry, then add water to the Danshen clean medicinal material and boil it for 3 times, 12 times the water each time, 1.5 hours, filter the extract, combine the filtrate, and concentrate under reduced pressure to a clear paste with a relative density of 1.13-1.17 (70°C), add an appropriate amount of ethanol to adjust the alcohol content to 60%, stir for 30 minutes, and let it stand for 16 hours; add an appropriate amount of ethanol to make the alcohol content reach 80%, stir for 30 minutes, let it stand for 16 hours, recover the supernatant under reduced pressure ethanol, and concentrate it to a clear paste with a relative density of 1.10-1.20 (55-60°C), transfer it to a Danshen treatment clean room, continue to concentrate under reduced pressure to a relative density of 1.28-1.32 (55-60°C), cool it to obtain Danshen green paste, and set it aside;

[0009] S3: Weigh the formula amount of artificial musk, total saponins of ginseng stems and leaves, toad venom extract, danshen paste, artificial bezoar, bear bile powder, borneol, polyethylene glycol 6000, polysorbate 80, put the weighed polyethylene glycol 6000 into an external seasoning tank, set the temperature to 85°C, start the stirring device after more than 3 / 4 of the polyethylene glycol 6000 is melted, wait until the materials in the external seasoning tank are completely melted and reach the preset temperature, and add the materials according to the following steps:

[0010] ① Add about the same amount of ethanol to the toad venom extract in the homogenizer, set the medium speed to stir for 20 to 30 minutes to make it dispersed evenly, and then add it to the external seasoning tank;

[0011] ② Add bear bile powder, Danshen paste, ginseng stem and leaf total saponins, and artificial bezoar into purified water, fully moisten and disperse them, and then add them into the external seasoning tank;

[0012] ③ Add artificial musk to molten polyethylene glycol 6000 and stir until there is no dry particle polymer, then add it to the external seasoning tank;

[0013] ④ Add polysorbate 80 into the external seasoning tank;

[0014] ⑤ Moisten borneol with ethanol and add it to polyethylene glycol 6000;

[0015] After the above materials are added, in order to ensure full mixing, the stirring time in the external stirring tank should be no less than 30 minutes;

[0016] S4: dripping, centrifugation, screening and drying, coating, inner packaging and outer packaging. Add the prepared liquid medicine into the built-in seasoning tank and stir for no less than 30 minutes for dripping. Make the pills round. The average pill weight is 29.0-33.5 mg. The pills with qualified weight difference and appearance are put into the centrifuge cup in equal amounts. The centrifuge speed is 1400 rpm, each time for 5 minutes, centrifuge 3 times, and screen the pills after centrifugation until there is no obvious dimethicone oil attached to the surface.

[0017] Preferably, in the cleaning process in S2, a medicine washing tank device is used to clean the salvia miltiorrhiza, and the medicine washing tank device comprises:

[0018] A medicine washing tank box body, wherein the medicine washing tank box body has a medicine washing pool for containing washing water;

[0019] A cleaning screen frame is set up in the medicine washing pool so that the bottom of the cleaning screen frame is immersed in flowing water, and at the same time, the salvia miltiorrhiza to be cleaned is poured into the cleaning screen frame so that the salvia miltiorrhiza can be immersed in the flowing water;

[0020] A cleaning roller is suspended in the medicine washing pool and is capable of rotating and lifting to contact the salvia miltiorrhiza soaked in water;

[0021] The three-axis moving module spans over the medicine washing tank box and is connected with the cleaning roller.

[0022] A preparation device for Musk Tongxin Drop Pills, wherein a cleaning assembly is arranged around the cleaning screen frame and close to the inner wall of the medicine washing pool, and the cleaning assembly comprises a silica gel cleaning screen frame;

[0023] The inner wall of the silica gel cleaning screen frame is provided with a plurality of flexible contact elements;

[0024] The flexible contact element can rub and touch different surfaces of the salvia miltiorrhiza in the cleaning screen frame.

[0025] Preferably, the surface of the silicone cleaning net frame is covered with first cleaning dust removal holes, and each of the flexible contact elements is arranged around the first cleaning dust removal holes and located on the inner wall of the silicone cleaning net frame.

[0026] Preferably, the flexible contact element comprises a vertical silicone cleaning strip fixed to the inner wall of the silicone cleaning frame between two adjacent first cleaning and dust removal holes, a first silicone cleaning strip obliquely arranged on one side of the vertical silicone cleaning strip, and a second silicone cleaning strip obliquely arranged on the other side of the vertical silicone cleaning strip;

[0027] The first silicone cleaning strip and the second silicone cleaning strip are flexibly cross-arranged, and the free ends of the vertical silicone cleaning strip, the first silicone cleaning strip and the second silicone cleaning strip are all inserted into the interior from the second cleaning dust removal hole of the cleaning screen frame and are in friction contact with the salvia miltiorrhiza immersed in water.

[0028] Preferably, a cleaning cotton pad is bonded to the inner wall of the cleaning screen frame, and a through hole with the same aperture as the second cleaning dust discharge hole is provided on the surface of the cleaning cotton pad;

[0029] The material of the sponge pad of the cleaning cotton pad is used to construct the contact surface inside the cleaning screen frame.

[0030] Preferably, the surrounding fixed sleeve of the cleaning roller is provided with a silicone cleaning sleeve, and the surrounding outer wall of the silicone cleaning sleeve is densely provided with silicone cleaning protrusions. The silicone cleaning protrusions are in frictional contact with the salvia miltiorrhiza, and the silicone cleaning protrusions of the silicone cleaning sleeve squeeze the salvia miltiorrhiza to help remove dust and impurities.

[0031] Preferably, the top surfaces of both ends of the cleaning screen frame are welded with inverted supporting ear plates, so that the two supporting ear plates suspend the cleaning screen frame in the medicine washing pool, and the supporting ear plates are suspended on the edge of the medicine washing pool, and the horizontal bottom surface of each of the supporting ear plates is symmetrically welded with two positioning uprights, four positioning uprights are grouped in twos, and the two groups are symmetrically distributed on both sides of the medicine washing pool, so that each positioning upright is located outside the medicine washing pool and longitudinally inserted into the medicine washing tank box, and the vibrating material turning mechanism includes a rotating shaft rotatably installed between the two upright plates, an eccentric wheel disc symmetrically fixed at both ends of the circumference of the rotating shaft, and a second servo motor fixed to the outer wall of one of the upright plates.

[0032] Compared with the prior art, the technical effects and advantages of the present invention are as follows:

[0033] The preparation method and device of the Musk Tongxin Dropping Pills, the Musk Tongxin Dropping Pills of the invention have significant clinical efficacy, no side effects, high drug stability, fast dissolution, high efficiency, rapid effect, high bioavailability, and are easy to carry and take.

[0034] The present invention utilizes the synergistic effect of the cleaning roller, the silicone cleaning sleeve and the vibrating material turning mechanism to ensure that all surfaces of the salvia miltiorrhiza can be fully cleaned. In particular, the three-axis moving module can accurately adjust the position of the cleaning roller, so that the cleaning range is wider and the cleaning is more uniform.

[0035] The vertical silicone cleaning strips, the first silicone cleaning strips and the second silicone cleaning strips in the silicone cleaning screen frame and the silicone cleaning strip components of the present invention are cross-arranged, and can be in frictional contact with different surfaces of the salvia miltiorrhiza during the cleaning process, providing a comprehensive and detailed cleaning effect. This design not only increases the cleaning area, but also effectively removes fine dust and impurities on the surface of the salvia miltiorrhiza, avoiding dead corners that are easily missed in traditional cleaning methods. The vibrating material turning mechanism continuously turns the salvia miltiorrhiza in the cleaning screen frame through the periodic lifting of the eccentric wheel disc, ensuring that all sides of each salvia miltiorrhiza can be fully cleaned. This mechanism also promotes the flow of water, further improving the cleaning efficiency.

[0036] The design of the silicone cleaning protrusions and silicone cleaning strip components on the silicone cleaning sleeve of the present invention provides good friction without causing mechanical damage to the salvia miltiorrhiza. The use of the cleaning cotton pad further protects the salvia miltiorrhiza from being squeezed or worn during the cleaning process, ensuring that the integrity and efficacy of the medicinal material are not affected. The hydraulic lifting column can adjust the height of the cleaning roller according to the size and shape of the salvia miltiorrhiza, ensuring that the silicone cleaning sleeve maintains appropriate contact pressure with the surface of the salvia miltiorrhiza, which will not cause damage due to excessive pressure, and can ensure sufficient friction for effective cleaning.

[0037] The silicone cleaning screen frame and silicone cleaning strip components arranged around the cleaning screen frame provide additional flexible contact elements, including vertical silicone cleaning strips, first silicone cleaning strips, and second silicone cleaning strips. These silicone cleaning strips are arranged crosswise, and can be in frictional contact with different surfaces of the salvia miltiorrhiza during the cleaning process, providing a comprehensive and detailed cleaning effect. In addition, the free end of the silicone cleaning strip can be inserted from the second cleaning dust discharge hole into the interior of the cleaning screen frame to help remove dust and impurities on the surface of the salvia miltiorrhiza and prevent the dust discharge hole from being blocked. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] In order to more clearly illustrate the specific implementation methods of the present invention or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0039] Figure 1 It is a structural schematic diagram of the present invention.

[0040] Figure 2 It is a schematic diagram of the disassembled structure of the medicine washing tank box and the three-axis moving module of the present invention.

[0041] Figure 3 It is a structural schematic diagram of the three-axis moving module of the present invention.

[0042] Figure 4 It is a schematic diagram of the connection structure of the cleaning roller of the present invention.

[0043] Figure 5 It is a schematic structural diagram of the cleaning screen frame of the present invention.

[0044] Figure 6 It is a schematic structural diagram of the in-pool cleaning assembly of the present invention.

[0045] Figure 7 It is a cross-sectional view of the silica gel cleaning screen frame of the present invention.

[0046] Figure 8 It is a cross-sectional view of the cleaning screen frame of the present invention.

[0047] Fig. 9 The present invention provides a flow chart of the production process of Musk Tongxin Dropping Pills.

[0048] Description of reference numerals:

[0049] In the figure: 1. medicine washing tank device; 2. medicine washing tank box; 3. medicine washing pool; 4. three-axis moving module; 5. U-shaped bracket; 6. cleaning roller; 7. silicone cleaning sleeve; 8. water inlet; 9. X-axis guide rail; 10. Y-axis guide rail; 11. cleaning screen frame; 12. control panel; 13. supporting connecting rod; 14. power distribution control box; 15. moving wheel; 16. U-shaped bearing slider seat; 17. U-shaped lifting plate; 18. first servo motor; 19. hydraulic lifting column; 20. rib Plate; 21. Support ear plate; 22. Cleaning cotton pad; 23. Positioning pole; 24. Lifting connecting plate; 25. Compression spring; 26. Eccentric wheel; 27. Vertical plate; 28. Second servo motor; 29. ​​Rotating shaft; 30. In-pool cleaning assembly; 31. Silicone cleaning net frame; 32. Silicone cleaning bar component; 321. Vertical silicone cleaning bar; 322. First silicone cleaning bar; 323. Second silicone cleaning bar; 33. First cleaning dust exhaust hole; 34. Second cleaning dust exhaust hole. DETAILED DESCRIPTION

[0050] In the following description, a large number of specific details are provided to provide a more thorough understanding of the present invention. However, it is apparent to those skilled in the art that the present invention can be implemented without one or more of these details. In other examples, in order to avoid confusion with the present invention, some technical features well known in the art are not described.

[0051] Unless otherwise defined, the up, down, left, right, front, back, inside and outside directions involved in this document are based on the up, down, left, right, front, back, inside and outside directions in the figures shown in the present invention, and are explained here together.

[0052] The present invention provides Figures 1 to 9 The invention discloses a method and device for preparing Musk Tongxin Dropping Pills.

[0053] Example 1: Musk Tongxin Dropping Pills are prepared by weighing the following components in parts by weight: 18 to 20 parts of artificial musk, 30 to 40 parts of total saponins from ginseng stems and leaves, 100 to 120 parts of toad venom, 500 to 550 parts of salvia miltiorrhiza, 60 to 65 parts of artificial bezoar, 26 to 30 parts of bear bile powder, and 52 to 60 parts of borneol.

[0054] In Example 2 of the present invention, Musk Tongxin Dropping Pills are prepared by weighing the following components in parts by weight: 18 parts of artificial musk, 30 parts of total saponins from ginseng stems and leaves, 100 parts of toad venom, 500 parts of salvia miltiorrhiza, 60 parts of artificial bezoars, 26 parts of bear bile powder, and 52 parts of borneol.

[0055] In Example 3 of the present invention, Musk Tongxin Dropping Pills are prepared by weighing the following components in parts by weight: 20 parts of artificial musk, 40 parts of total saponins of ginseng stems and leaves, 120 parts of toad venom, 550 parts of salvia miltiorrhiza, 65 parts of artificial bezoars, 30 parts of bear bile powder, and 60 parts of borneol.

[0056] In Example 4 of the present invention, Musk Tongxin Dropping Pills are prepared by weighing the following components in parts by weight: 20 parts of artificial musk, 30 parts of total saponins from ginseng stems and leaves, 120 parts of toad venom, 500 parts of salvia miltiorrhiza, 65 parts of artificial bezoars, 26 parts of bear bile powder, and 60 parts of borneol.

[0057] In Example 5 of the present invention, Musk Tongxin Dropping Pills are prepared by weighing the following components in parts by weight: 19 parts of artificial musk, 35 parts of total saponins of ginseng stems and leaves, 110 parts of toad venom, 530 parts of salvia miltiorrhiza, 63 parts of artificial bezoar, 28 parts of bear bile powder, and 56 parts of borneol.

[0058] A method for preparing Shexiang Tongxin Dropping Pills specifically comprises the following steps:

[0059] S1. Clean and select Danshen. Pour the raw medicinal materials received onto the operating table, pick out the non-medicinal parts and other impurities, and sieve them if necessary. Put the qualified Danshen medicinal materials into a clean canvas bag, weigh them, hang labels on them, and place them in the designated location for cleaning.

[0060] S2. Washing of Danshen. Fill the washing tank with drinking water and keep it flowing. Put the cleaned Danshen into the sieve and rinse it in the washing tank. The cleaning standard is that there is no dirt adhering to the medicinal materials and the original color of the medicinal materials can be seen. The washed Danshen is loaded into the receiving car and transferred to the infiltration process.

[0061] S3, Danshen soaking, put the cleaned Danshen medicinal materials into the material cart and push them into the medicine soaking tank. The steam pressure of the medicine soaking tank is below 0.02Mpa, the medicine soaking temperature is between 60-70℃, and the time is about 15-30 minutes. The equipment used is RYG-2400 medicine soaking tank. (Actually soaking in the medicine washing tank).

[0062] S4, Danshen cutting, cut the soaked Danshen into 4-5cm long sections, put them into the material car and prepare to be transferred to the drying process. The equipment used is QYJ-300D reciprocating medicine cutting machine.

[0063] S5. Drying of Danshen: Put the cut Danshen into a net-belt dryer with a transmission frequency of 12-20Hz, a steam pressure of ≤0.4Mpa, a drying temperature of 60-70℃, and dry for 1-2 hours. Or put the cut Danshen into a tray car and dry it in a drying room at a drying temperature of about 60℃ for about 6-8 hours. Prepare the dried Danshen for outer packaging.

[0064] S6. Extraction of Danshen. Add water to Danshen to decoct the pure medicinal materials for 3 times, 12 times the amount of water each time, for 1.5 hours. Filter the extract, combine the filtrates, and decompress and concentrate to a clear paste with a relative density of 1.13-1.17 (70°C). Add appropriate amount of ethanol to adjust the alcohol content to 60%, stir for 30 minutes, and let stand for 16 hours; add appropriate amount of ethanol to make the alcohol content reach 80%, stir for 30 minutes, let stand for 16 hours, recover the supernatant under reduced pressure and ethanol, and concentrate it to a clear paste with a relative density of 0.8-1.10 (55-60°C), transfer it to the Danshen treatment clean room, continue to decompress and concentrate it to a relative density of 1.28-1.32 (55~60°C), and cool it. The equipment used is: 1m 3 Rapid percolator, JC alcohol settling tank, 2000kg / h external circulation single-effect evaporator, QN-300 spherical concentrator.

[0065] S7. Weigh the formula amount of artificial musk, total saponins of ginseng stems and leaves, toad venom extract, danshen paste, artificial bezoar, bear bile powder, borneol, polyethylene glycol 6000, and polysorbate 80; put the weighed polyethylene glycol 6000 into an external seasoning tank, set the temperature to 85°C, and start the stirring device after more than 3 / 4 of the polyethylene glycol 6000 is melted. When the materials in the external seasoning tank are completely melted and reach the preset temperature, add the materials according to the following requirements:

[0066] ① Add about the same amount of ethanol to the toad venom extract in the homogenizer, set the medium speed to stir for 20 to 30 minutes to make it dispersed evenly, and then add it to the external seasoning tank;

[0067] ② Add bear bile powder, Danshen paste, ginseng stem and leaf total saponins, and artificial bezoar into purified water, fully moisten and disperse them, and then add them into the external seasoning tank;

[0068] ③ Add artificial musk to molten polyethylene glycol 6000 and stir until there is no dry particle polymer, then add it to the external seasoning tank;

[0069] ④ Add polysorbate 80 into the external seasoning tank;

[0070] ⑤ Moisten borneol with ethanol and add it to polyethylene glycol 6000.

[0071] After the above materials are added, in order to ensure full mixing, the stirring time in the external mixing tank should be no less than 30 minutes. Equipment used: 120L external seasoning tank.

[0072] S8, dripping, centrifugation, screening and drying, coating, inner packaging, outer packaging: Add the prepared liquid medicine into the built-in seasoning tank and stir for no less than 30 minutes, dripping, so that the pills are round, and the average pill weight of the dripping is 29.0-33.5 mg. The pills with qualified weight difference and appearance are put into the centrifuge cup in equal amounts, and the centrifuge speed is 1400 rpm, 5 minutes each time, and centrifuged 3 times. The centrifuged pills are screened until there is no obvious dimethyl silicone oil attached to the surface. After selection, they are packed into stainless steel barrels or polyethylene bags and sent to the intermediate station for storage. After passing the inspection, they are passed to the next process. Equipment used: DWJ-2000D automatic dripping pill machine, DWJJL-2000 pill collecting centrifuge, DWJXSX-2000 rotary screening machine.

[0073] In the present invention, the weight of the intermediate product is weighed again, and the coating material is weighed. The film coating premix (gastric soluble type) (white) is collected and added at 3.9%-4.1% of the calculated weight of the intermediate product dripped, and the film coating premix (gastric soluble type) (brown) is collected and added at 8%-15% of the calculated weight of the intermediate product dripped. Specifically, according to the average pill weight of the drip-made pills, the average pill weight after coating reaches about 35.0 mg.

[0074] In the present invention, the bottom coating liquid is prepared: purified water is added into the coating liquid preparation tank, stirring is started, and the film coating premix (stomach-soluble type) (white) is slowly poured into the seasoning tank, so that the ratio of the film coating premix (stomach-soluble type) (white) in the final mixed liquid is 12:100, and stirring is performed while adding. The feeding speed is preferably such that no obvious agglomeration is generated. After the feeding is completed, stirring is continued for 1 hour to make it evenly dispersed.

[0075] In the present invention, the batch of pills is collected from the intermediate station, added into the coating pot, and coated with the white gastric soluble film coating premix. After the coating is completed, the peristaltic pump is turned off and the pills are dried.

[0076] In the present invention, the film coating premix (stomach-soluble type) (brown) coating solution is configured: purified water is added to the coating solution preparation tank, stirring is started, the film coating premix (stomach-soluble type) (brown) is slowly added to the seasoning tank, the ratio of the film coating premix (stomach-soluble type) (brown) in the final mixed solution is 18:100, stirring while adding, the feeding speed is preferably not to produce obvious agglomeration, after the feeding is completed, stirring for another 1 hour, so that it is evenly dispersed. Spraying is turned on to coat the brown stomach-soluble film coating premix.

[0077] In the present invention, after the average pill weight reaches the requirement, the peristaltic pump is turned off, and the heating is stopped after the pills are dried. When the pill temperature drops below 30° C., the coating pan is stopped from rotating, the material is discharged, loaded into a stainless steel barrel or a polyethylene bag, sealed, weighed, and transferred to an intermediate station for temporary storage.

[0078] In the present invention, the coated Musk Tongxin Drop Pills are subjected to pill selection, and the weight of each pill is compared with the marked pill weight, and the weight difference limit is ±10%. No more than 2 pills exceed the weight difference limit, and no pill exceeds the limit by 1 times. The selected sticky pills, oversized and undersized pills, and the qualified products after screening are put into stainless steel barrels or polyethylene bags and sent to the intermediate station, and are passed to the next process after passing the inspection. Equipment used: JGB-75C high-efficiency coating machine, rotary pill selection machine.

[0079] In the present invention, inner packaging: two different packaging machines, different temperature parameters, refer to Table 1: the temperature of the No. 1 heating plate is 130°C, the temperature of the No. 2 heating plate is 135°C, and the sealing temperature is 190°C during the packaging process for the packaging of 18 pills / plate; the temperature of the No. 1 heating plate is 125°C, the temperature of the No. 2 heating plate is 130°C, and the sealing temperature is 170°C during the packaging process for the packaging of 36 pills / plate, which can be adjusted up and down according to actual conditions, and the adjustment temperature does not exceed 5°C. After confirming that the printed batch number and production date are qualified, start unloading and carry out inner packaging. Equipment used: B1240 aluminum-plastic packaging machine.

[0080] Table 1 Aluminum-plastic packaging machine equipment parameters

[0081]

[0082] In the present invention, the plates are swung: unqualified plates are removed when swung, and qualified aluminum-plastic plates are required to be flat, neatly stacked, and in the same direction, without foreign matter, indentation, damage, empty pills, pressed pills, broken pills, and the batch number is clearly identifiable.

[0083] In the present invention, wallet packaging: after confirming that the printed product batch number, production date and validity period are correct, wallet packaging is carried out. Equipment used: HH-0085-011 wallet machine.

[0084] In the present invention, outer packaging: the printed large box is distributed to the packaging personnel, who fold the large box into shape, paste animal labels on the packed small boxes, and scan the codes one by one, and pack every 10 small boxes into a large box, and the scanned codes are associated with the small boxes. The qualified printed cartons are folded into shape, and the bottom of the cartons are sealed with tape.

[0085] Put the gasket in place, put every 40 (or 20) large boxes into a carton, scan the code again to associate with the large box, put in the certificate and gasket, seal the box mouth with tape, and press the seal tightly and flatly. Equipment used: A-Pe inkjet printer.

[0086] Embodiment 6 of the present invention:

[0087] A method for preparing Musk Tongxin Drop Pills, wherein the cleaning step in S2 uses a medicine washing tank device 1 to clean Danshen.

[0088] In this embodiment, the medicine washing tank device 1 includes a medicine washing tank box 2, a cleaning screen frame 11, a cleaning roller 6, and a three-axis moving module 4.

[0089] In this embodiment, the medicine washing tank housing 2 has a medicine washing pool 3 for containing washing water; the cleaning screen frame 11 is set up in the medicine washing pool 3 so that the bottom of the cleaning screen frame 11 is immersed in the flowing water, and the salvia miltiorrhiza to be washed is poured into the cleaning screen frame 11 so that the salvia miltiorrhiza can be immersed in the flowing water; the cleaning roller 6 is suspended in the medicine washing pool 3 and can perform rotation and lifting actions to contact the salvia miltiorrhiza immersed in the water; the three-axis moving module 4 spans above the medicine washing tank housing 2 and is connected to the cleaning roller 6. The bottom cross-section of the medicine washing pool 3 is a semicircular structure, and the bottoms of the cleaning screen frame 11 and the silicone cleaning screen frame 31 are also semicircular structures.

[0090] In this embodiment, the medicine washing pool 3 is used to hold the washing water to ensure that the salvia miltiorrhiza can be fully soaked and washed in the flowing water. Its bottom is designed in a semicircular shape, which helps to reduce dead angles, facilitates smooth water flow and discharge of impurities. Through the X-axis guide rail 9, the Y-axis guide rail 10 and the U-shaped bearing slider seat 16, a multi-directional movement capability is provided, so that the cleaning roller 6 can be accurately positioned to the position required for cleaning, increasing the flexibility and coverage of cleaning. The cleaning roller 6 is used in conjunction with the silicone cleaning sleeve 7, and directly contacts the salvia miltiorrhiza immersed in the water through rotation and lifting actions, and the silicone cleaning bumps on the silicone cleaning sleeve 7 are used to frictionally clean the surface of the salvia miltiorrhiza, effectively removing dust and impurities. The cleaning screen frame 11 is used to load the salvia miltiorrhiza to be cleaned, and its bottom is immersed in the flowing water to ensure that the salvia miltiorrhiza is completely immersed. A second cleaning dust discharge hole 34 is provided at the bottom of the cleaning screen frame 11, which can help screen out fine impurities and dust generated during the cleaning process to prevent clogging.

[0091] A preparation device for Musk Tongxin Drop Pills, wherein an in-pool cleaning component 30 is arranged around a cleaning screen frame 11 and close to the inner wall in a medicine washing pool 3, wherein the in-pool cleaning component 30 comprises a silicone cleaning screen frame 31; a plurality of flexible contact elements are arranged on the inner wall of the silicone cleaning screen frame 31; the flexible contact elements can rub and touch different surfaces of salvia miltiorrhiza in the cleaning screen frame 11.

[0092] In this embodiment, the surface of the silicone cleaning mesh frame 31 is covered with first cleaning dust discharge holes 33, and each flexible contact element is arranged around the first cleaning dust discharge hole 33 and located on the inner wall of the silicone cleaning mesh frame 31. The silicone cleaning mesh frame 31 surrounds the cleaning screen frame 11, and its inner wall is covered with first cleaning dust discharge holes 33, which are used to discharge fine impurities and dust generated during the cleaning process to prevent clogging.

[0093] In this embodiment, the flexible contact element includes a vertical silicone cleaning strip 321 fixed to the inner wall of the silicone cleaning frame 31 between two adjacent first cleaning and dust removal holes 33, a first silicone cleaning strip 322 obliquely arranged on one side of the vertical silicone cleaning strip 321, and a second silicone cleaning strip 323 obliquely arranged on the other side of the vertical silicone cleaning strip 321.

[0094] In this embodiment, the first silicone cleaning strip 322 and the second silicone cleaning strip 323 are flexibly cross-arranged, and the free ends of the vertical silicone cleaning strip 321, the first silicone cleaning strip 322 and the second silicone cleaning strip 323 are all plugged into the second cleaning dust removal hole 34 of the cleaning screen frame 11 to the inside and frictionally contact with the salvia miltiorrhiza immersed in water, so as to achieve cleaning of different surfaces of the salvia miltiorrhiza. At the same time, the free ends of the vertical silicone cleaning strip 321, the first silicone cleaning strip 322 and the second silicone cleaning strip 323 are all plugged into the second cleaning dust removal hole 34, which can clean the dust in the second cleaning dust removal hole 34 and prevent the second cleaning dust removal hole 34 from being blocked.

[0095] In this embodiment, a cleaning cotton pad 22 is bonded to the inner wall of the cleaning screen frame 11, and a through hole with the same aperture as the second cleaning dust discharge hole 34 is provided on the surface of the cleaning cotton pad 22. The cleaning cotton pad 22 is bonded to the inner wall of the cleaning screen frame 11 to provide additional friction to help remove dust and impurities on the surface of the salvia miltiorrhiza, and at the same time wrap the salvia miltiorrhiza during the cleaning process to protect it from being damaged.

[0096] In this embodiment, the material of the cleaning cotton pad 22 sponge pad is used to construct the contact surface inside the cleaning screen frame 11. The material of the cleaning cotton pad 22 can provide good friction without affecting the integrity of the Salvia miltiorrhiza, and help remove dust and impurities. At the same time, when the cleaning roller 6 and the silicone cleaning sleeve 7 squeeze the Salvia miltiorrhiza, the Salvia miltiorrhiza can squeeze the cleaning cotton pad 22 and be wrapped by the cleaning cotton pad 22. When the cleaning roller 6 and the silicone cleaning sleeve 7 are driven to roll, friction can be provided to the Salvia miltiorrhiza to remove surface dust. The cleaning cotton pad 22 can touch different surfaces of the Salvia miltiorrhiza, including uneven parts.

[0097] In this embodiment, a vibrating material turning mechanism is provided below the cleaning screen frame 11 and the medicine washing pool 3 and inside the medicine washing tank box 2. The driving end of the vibrating material turning mechanism is driven on the cleaning screen frame 11 through a continuous driving connection component, so that the cleaning screen frame 11 performs a longitudinal lifting action in the medicine washing pool 3, so that the salvia miltiorrhiza in the cleaning screen frame 11 is vibrated and bumped, thereby achieving a flipping effect, which is helpful for cleaning different surfaces. At the same time, this vibration flipping and bumping action also helps to remove dust and impurities from the cleaning screen frame 11 from the second cleaning The dust is screened out through the dust exhaust hole 34. In addition, when the cleaning screen frame 11 is vibrated and shaken, the cleaning screen frame 11 presses down the silicone cleaning bar component 32 when it descends, so that the vertical silicone cleaning bar 321, the first silicone cleaning bar 322 and the second silicone cleaning bar 323 of the silicone cleaning bar component 32 are again plugged into the silicone cleaning frame 31 to frictionally clean different surfaces of the Salvia miltiorrhiza. Under the design of the vertical silicone cleaning bar 321, the first silicone cleaning bar 322 and the second silicone cleaning bar 323, the cleaning area is increased and the cleaning of different surfaces can be met.

[0098] In this embodiment, a silicone cleaning sleeve 7 is provided on the peripheral fixed sleeve of the cleaning roller 6, and silicone cleaning protrusions are densely arranged on the peripheral outer wall of the silicone cleaning sleeve 7. The silicone cleaning protrusions are in frictional contact with the salvia miltiorrhiza. The silicone cleaning protrusions of the silicone cleaning sleeve 7 squeeze the salvia miltiorrhiza, providing good friction without affecting the integrity of the salvia miltiorrhiza (without damaging it), thereby helping to remove dust and impurities.

[0099] In this embodiment, the three-axis mobile module 4 includes two inverted U-shaped brackets 5 symmetrically spanning above the medicine washing tank box 2, X-axis guide rails 9 symmetrically installed on the top surface of each U-shaped bracket 5, a Y-axis guide rail 10 slidably connected between the two X-axis guide rails 9, a U-shaped load-bearing slider seat 16 slidably connected to the Y-axis guide rail 10, and a hydraulic lifting column 19 fixed to the bottom surface of the U-shaped load-bearing slider seat 16, a rib plate 20 is welded to the bottom lifting end of the hydraulic lifting column 19, an inverted U-shaped hanging plate 17 is welded to the bottom surface of the rib plate 20, the cleaning roller 6 is rotatably installed in the U-shaped hanging plate 17, a first servo motor 18 is installed on one side outer wall of the U-shaped hanging plate 17, the output shaft of the first servo motor 18 passes through the U-shaped hanging plate 17 and is fixedly connected to the cleaning roller 6, so that the first servo motor 18 drives the cleaning roller 6 to rotate in the U-shaped hanging plate 17, so that the rotating cleaning roller 6 drives the silicone cleaning sleeve 7 to frictionally clean the surface of the salvia miltiorrhiza immersed in running water. At the same time, the X-axis guide rail 9 and the Y-axis guide rail 10 drive the position adjustment of the cleaning roller 6 and the silicone cleaning sleeve 7, and rub the salvia miltiorrhiza in the cleaning screen frame 11. When the rotating silicone cleaning sleeve 7 is driven by the X-axis guide rail 9 and the Y-axis guide rail 10, it provides a force to rotate and rub the salvia miltiorrhiza, which further improves the cleaning efficiency. The cleaning of the cleaning roller 6 and the silicone cleaning sleeve 7 in the cleaning screen frame 11 when they are not in position is static cleaning, and the rotating silicone cleaning sleeve 7 is driven by the X-axis guide rail 9 and the Y-axis guide rail 10. It is dynamic cleaning, and the two-stage cleaning further improves the cleaning efficiency and quality. The hydraulic lifting column 19 drives the U-shaped lifting plate 17 to rise and fall, so that the adjustment silicone cleaning sleeve 7 rises and falls and contacts with the salvia miltiorrhiza. A moving wheel 15 is fixed to the bottom end of each U-shaped bracket 5, so as to facilitate the movement of the three-axis moving module 4 across the medicine washing tank box 2 and to facilitate withdrawal. At the same time, support rods 13 are symmetrically welded on both sides between the two U-shaped brackets 5, and a power distribution control box 14 is fixed between two adjacent support rods 13. The power distribution control box 14 is provided with a PLC for controlling the opening and closing of the X-axis guide rail 9, the Y-axis guide rail 10, the hydraulic lifting column 19 and the first servo motor 18. The surface of the power distribution control box 14 has a display screen and buttons.

[0100] In this embodiment, inverted support ear plates 21 are welded to the top surfaces of both ends of the cleaning screen frame 11, so that the two support ear plates 21 suspend the cleaning screen frame 11 in the medicine washing pool 3, and the support ear plates 21 are suspended on the edge of the medicine washing pool 3, and the horizontal bottom surface of each support ear plate 21 is symmetrically welded with two positioning vertical rods 23, and the four positioning vertical rods 23 are grouped in pairs, and the two groups are symmetrically distributed on both sides of the medicine washing pool 3, so that each positioning vertical rod 23 is located outside the medicine washing pool 3 and longitudinally inserted into the medicine washing tank box body 2, and the vibrating material turning mechanism is arranged in the medicine washing tank box body 2 below the medicine washing pool 3, and each group of positioning The bottom end of the vertical pole 23 is welded with a lifting connecting plate 24, and compression springs 25 are welded on both sides of the bottom surface of each lifting connecting plate 24. There is a chamber for accommodating the vibration turning mechanism below the medicine washing pool 3 and located in the medicine washing tank box 2. This chamber is not connected to the medicine washing pool 3, and the bottom end of the compression spring 25 is welded to the inner bottom wall of the chamber. The top of the compression spring 25 elastically abuts against the bottom surface of the lifting connecting plate 24 upward. The positioning vertical pole 23 connects the support ear plate 21 and the lifting connecting plate 24 to ensure that the cleaning screen frame 11 is in the correct position in the medicine washing pool 3, and realizes elastic support through the compression spring 25. The lifting connecting plate 24 is welded to the bottom end of the positioning vertical pole 23 and is driven by the eccentric wheel disc 26 to realize the lifting and lowering action of the cleaning screen frame 11, and promote the flipping and cleaning of the salvia miltiorrhiza. Two vertical plates 27 are symmetrically welded to the inner bottom wall of the chamber. The vibrating material turning mechanism includes a rotating shaft 29 rotatably installed between the two vertical plates 27, an eccentric wheel 26 symmetrically fixed to both ends of the rotating shaft 29, and a second servo motor 28 fixed to the outer wall of one of the vertical plates 27. When the second servo motor 28 drives the rotating shaft 29, the rotating shaft 29 drives the two eccentric discs 26 to rotate synchronously, so that the eccentric ends of the two eccentric discs 26 synchronously lift the lifting connecting plate 24 upward. Under the lifting action of the eccentric disc 26, the lifting connecting plate 24 lifts the positioning rod 23, and the positioning rod 23 drives the supporting ear plate 21 and the cleaning screen frame 11 to lift upward in the medicine washing pool 3. When the eccentric end of the eccentric disc 26 turns away from contacting the lifting connecting plate 24, the lifting connecting plate 24 drives the positioning rod 23, the supporting ear plate 21 and the cleaning screen frame 11 to descend in the medicine washing pool 3. In this way, under the rotation state of the eccentric disc 26, the cleaning screen frame 11 performs the action of rising and falling in the medicine washing pool 3, so as to achieve the effect of Danshen turning material cleaning and the second cleaning dust discharge hole 34 anti-blocking. The periodic lifting action of the eccentric disc 26 is combined with the elastic support of the compression spring 25 to form a flexible vibration system. This design not only makes the lifting and lowering of the cleaning screen frame 11 more stable, but also can automatically adjust the vibration intensity according to the weight and density of the salvia miltiorrhiza, ensuring stability and safety during the cleaning process. The combination of the eccentric wheel 26 and the compression spring 25 not only provides stable vibration support, but also can absorb part of the impact force during the cleaning process, reducing the wear of the equipment. This elastic support mechanism extends the service life of the equipment and reduces maintenance costs.

[0101] In this embodiment, a water inlet 8 is provided above the cleaning screen frame 11 and on the inner wall of the medicine washing pool 3. The back of the medicine washing tank box 2 has a water pipe connected to the water inlet 8. The water pipe is connected to an external water source and conveys water from the water inlet 8 into the medicine washing pool 3 under the action of a water pump. There is a drain (not shown) at the bottom of the medicine washing pool 3. The drain has an electromagnetic water valve, so that water enters the water inlet 8 and the drain is drained. Water can flow in the medicine washing pool 3 and dust is discharged from the drain. There is a control panel 12 on the outer wall of the medicine washing tank box 2. The control panel 12 has a PLC for controlling the electromagnetic water valve, the water pump and the second servo motor 28. The surface of the control panel 12 has a display screen and operation buttons.

[0102] In this embodiment, the vibration turning mechanism can not only turn the salvia miltiorrhiza in the cleaning screen frame 11 to ensure that each surface can be fully cleaned, but also automatically clean the second cleaning dust discharge hole 34 through its periodic lifting action. When the cleaning screen frame 11 descends, the vertical silicone cleaning strip 321, the first silicone cleaning strip 322 and the second silicone cleaning strip 323 in the silicone cleaning strip component 32 will be plugged into the second cleaning dust discharge hole 34 again to clean the dust discharge hole and prevent it from being blocked. This design not only realizes the turning of the salvia miltiorrhiza, but also indirectly cleans the dust discharge hole through its mechanical movement, forming a self-cleaning mechanism. This dual effect makes the cleaning process smoother and avoids the problem of incomplete cleaning caused by the blockage of the dust discharge hole.

[0103] In this embodiment, the silicone cleaning protrusions on the silicone cleaning sleeve 7 and the cleaning cotton pad 22 for cleaning the inner wall of the screen frame 11 form a dual friction system. During the cleaning process, the rotation and lifting action of the silicone cleaning sleeve 7 not only directly rubs the surface of the Salvia miltiorrhiza, but also further wraps and squeezes the Salvia miltiorrhiza through the cleaning cotton pad 22, providing additional friction. This synergistic effect not only improves the cleaning effect, but also protects the Salvia miltiorrhiza to a certain extent, preventing it from being damaged by excessive friction. The combination of the silicone cleaning sleeve 7 and the cleaning cotton pad 22 not only enhances the cleaning strength, but also provides buffer protection to ensure that the Salvia miltiorrhiza will not be damaged due to excessive friction during the cleaning process. This design not only ensures the cleaning quality, but also protects the integrity of the medicinal material.

[0104] Working principle:

[0105] Open the valve of the water inlet 8, start the water pump, and inject clean water into the medicine washing pool 3 until the water level is moderate, ensuring that the salvia miltiorrhiza in the cleaning screen frame 11 can be completely immersed in water. At this time, the salvia miltiorrhiza will be initially soaked to soften the dirt attached to the surface, and the salvia miltiorrhiza will be gradually soaked by the flowing water in the cleaning screen frame 11, and the initial cleaning will begin.

[0106] Through the cooperation of the X-axis guide rail 9 and the Y-axis guide rail 10, the three-axis moving module 4 can accurately adjust the position of the cleaning roller 6 to ensure that the cleaning roller 6 can cover all areas in the cleaning screen frame 11. The U-shaped bearing slider seat 16 slides along the Y-axis guide rail 10, and the U-shaped bracket 5 is moved to cross the top of the washing tank box 2 through the moving wheel 15. After the three-axis moving module 4 is locked, the stability of the entire three-axis moving module 4 is ensured.

[0107] The first servo motor 18 is started by the button of the power distribution control box 14 to drive the cleaning roller 6 to rotate. The outer wall of the silicone cleaning sleeve 7 on the cleaning roller 6 is densely provided with silicone cleaning bumps. As the cleaning roller 6 rotates, the silicone cleaning bumps will rub and clean the surface of the salvia miltiorrhiza, effectively removing dust and impurities. The hydraulic lifting column 19 is connected to the U-shaped lifting plate 17 through the rib plate 20 to control the lifting action of the cleaning roller 6. The hydraulic lifting column 19 can adjust the height of the cleaning roller 6 to ensure that the silicone cleaning sleeve 7 maintains an appropriate contact pressure with the surface of the salvia miltiorrhiza, which will not damage the salvia miltiorrhiza and provide sufficient friction.

[0108] The second servo motor 28 is started by the button on the control panel 12, driving the rotating shaft 29 to rotate, driving the two eccentric discs 26 to rotate synchronously. The eccentric end of the eccentric disc 26 periodically lifts the lifting connecting plate 24, so that the positioning upright 23 drives the supporting ear plate 21 and the cleaning screen frame 11 to perform the lifting and lowering action in the medicine washing pool 3. This vibration turning mechanism not only helps the salvia miltiorrhiza to turn over, ensuring that all surfaces can be fully cleaned, but also promotes the flow of water, further improving the cleaning effect.

[0109] During the cleaning process, the cleaning roller 6 and the silicone cleaning sleeve 7 can rotate and rub the salvia miltiorrhiza at a fixed position in the cleaning screen frame 11 to clean the salvia miltiorrhiza, and perform static cleaning; at the same time, the three-axis moving module 4 can also drive the cleaning roller 6 and the silicone cleaning sleeve 7 to move in the cleaning screen frame 11 to perform dynamic cleaning. The combination of these two cleaning methods can more thoroughly remove the dirt on the surface of the salvia miltiorrhiza and improve the cleaning efficiency.

[0110] The silicone cleaning mesh frame 31 and the silicone cleaning strip component 32 arranged around the cleaning screen frame 11 provide additional flexible contact elements, including vertical silicone cleaning strips 321, first silicone cleaning strips 322 and second silicone cleaning strips 323. These silicone cleaning strips are arranged crosswise, and can be in frictional contact with different surfaces of the salvia miltiorrhiza during the cleaning process, providing a comprehensive and detailed cleaning effect. In addition, the free end of the silicone cleaning strip can be inserted into the inside of the cleaning screen frame 11 from the second cleaning dust discharge hole 34, helping to remove dust and impurities on the surface of the salvia miltiorrhiza and prevent the dust discharge hole from being blocked.

[0111] The water flow in the medicine washing pool 3 is continuously replenished with fresh water through the water inlet 8 to ensure the quality of the washing water. The fine impurities and dust generated during the washing process will be discharged through the first cleaning dust discharge hole 33 and the second cleaning dust discharge hole 34 to prevent blockage. The electromagnetic water valve of the drain port can be opened regularly as needed to discharge the sewage after washing and keep the inside of the medicine washing pool 3 clean.

[0112] After cleaning is completed, close the valve of the water inlet 8 through the button on the control panel 12 to stop the water supply of the water pump. Open the electromagnetic water valve at the drain outlet to discharge the sewage in the medicine washing tank 3. After ensuring that all sewage is completely discharged, close the electromagnetic water valve at the drain outlet. Use tools or manually remove the cleaned Salvia miltiorrhiza from the cleaning screen frame 11 and prepare to enter the next process. The cleaned Salvia miltiorrhiza should be kept clean and moist, suitable for subsequent processing. After cleaning, the medicine washing tank device 1 is thoroughly cleaned, especially the cleaning screen frame 11, the silica gel cleaning mesh frame 31 and the silica gel cleaning strip component 32, to ensure that there is no residual Salvia miltiorrhiza or other impurities.

[0113] It should be noted that, in this article, relational terms such as one and two are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions. The sentence "includes an element defined by ... does not exclude the existence of other identical elements in the process, method, article or device including the element".

[0114] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A method for preparing Shexiang Tongxin Dropping Pills, characterized in that: The following steps are involved: S1, taking 500-550 parts of salvia miltiorrhiza, washing, soaking, cutting, drying, boiling, filtering, and concentrating under reduced pressure to prepare salvia miltiorrhiza paste; S2, weighing 18-20 parts of artificial musk, 30-40 parts of total saponins of ginseng stems and leaves, 100-120 parts of toad venom, 60-65 parts of artificial bezoars, 26-30 parts of bear bile powder, 52-60 parts of borneol, and the Danshen clear paste obtained in S1, adding polyethylene glycol 6000 and polysorbate 80, stirring and mixing evenly, dripping, centrifuging, screening and drying, and coating to obtain Musk Tongxin Dropping Pills; The above parts are all by weight; The cleaning process in S1 uses a medicine washing tank (1) to clean the salvia miltiorrhiza, wherein the medicine washing tank (1) comprises a medicine washing tank box (2), and the medicine washing tank box (2) has a medicine washing pool (3) for containing cleaning water; A cleaning screen frame (11) is set up in the medicine washing pool (3) so that the bottom of the cleaning screen frame (11) is immersed in flowing water, and at the same time, the salvia miltiorrhiza to be cleaned is poured into the cleaning screen frame (11) so that the salvia miltiorrhiza can be immersed in the flowing water; A cleaning roller (6) is suspended in the medicine washing pool (3) and is capable of rotating and lifting to contact the salvia miltiorrhiza soaked in water; The three-axis movable module (4) spans over the medicine washing tank box (2) and is connected to the cleaning roller (6).

2. A preparation device for Musk Tongxin Dropping Pills, characterized in that: It comprises a medicine washing tank (1), wherein the medicine washing tank (1) comprises a medicine washing tank box (2), wherein the medicine washing tank box (2) has a medicine washing pool (3) for containing washing water; A cleaning screen frame (11) is set up in the medicine washing pool (3) so that the bottom of the cleaning screen frame (11) is immersed in flowing water, and at the same time, the salvia miltiorrhiza to be cleaned is poured into the cleaning screen frame (11) so that the salvia miltiorrhiza can be immersed in the flowing water; A cleaning roller (6) is suspended in the medicine washing pool (3) and is capable of rotating and lifting to contact the salvia miltiorrhiza soaked in water; A three-axis movable module (4) is arranged across the top of the medicine washing tank box (2) and is connected to the cleaning roller (6); an in-tank cleaning component (30) is arranged around the cleaning screen frame (11) and is located in the medicine washing tank (3) close to the inner wall, and the in-tank cleaning component (30) includes a silica gel cleaning screen frame (31); The inner wall of the silica gel cleaning screen frame (31) is provided with a plurality of flexible contact elements; The flexible contact element can rub and touch different surfaces of the salvia miltiorrhiza in the cleaning screen frame (11).

3. The preparation device of a Musk Tongxin Dropping Pill according to claim 2, characterized in that: The surface of the silica gel cleaning net frame (31) is covered with first cleaning dust removal holes (33), and each of the flexible contact elements is arranged around the first cleaning dust removal hole (33) and is located on the inner wall of the silica gel cleaning net frame (31).

4. The preparation device of Shexiang Tongxin Dropping Pills according to claim 3, characterized in that: The flexible contact element comprises a vertical silicone cleaning strip (321) fixed to the inner wall of the silicone cleaning net frame (31) between two adjacent first cleaning and dust removal holes (33), a first silicone cleaning strip (322) obliquely arranged on one side of the vertical silicone cleaning strip (321), and a second silicone cleaning strip (323) obliquely arranged on the other side of the vertical silicone cleaning strip (321).

5. The preparation device of Shexiang Tongxin Dropping Pills according to claim 4, characterized in that: The first silica gel cleaning strip (322) and the second silica gel cleaning strip (323) are flexibly arranged in a cross-shaped manner, and the free ends of the vertical silica gel cleaning strip (321), the first silica gel cleaning strip (322) and the second silica gel cleaning strip (323) are all inserted into the second cleaning dust removal hole (34) of the cleaning screen frame (11) and are in frictional contact with the salvia miltiorrhiza immersed in water, thereby achieving cleaning of different surfaces of the salvia miltiorrhiza; The free ends of the vertical silicone cleaning strip (321), the first silicone cleaning strip (322) and the second silicone cleaning strip (323) are all plugged into the second cleaning dust removal hole (34), so as to clean the dust in the second cleaning dust removal hole (34) and prevent the second cleaning dust removal hole (34) from being blocked.

6. The preparation device of Shexiang Tongxin Dropping Pills according to claim 5, characterized in that: A cleaning cotton pad (22) is bonded to the inner wall of the cleaning screen frame (11), and a through hole with the same aperture as the second cleaning dust discharge hole (34) is provided on the surface of the cleaning cotton pad (22); The material of the sponge pad of the cleaning cotton pad (22) is used to construct the contact surface inside the cleaning screen frame (11).

7. The preparation device of Shexiang Tongxin Dropping Pills according to claim 6, characterized in that: The cleaning roller (6) is fixedly sleeved with a silicone cleaning sleeve (7) on its circumferential side, and the outer wall of the silicone cleaning sleeve (7) is densely provided with silicone cleaning convex points, which are in frictional contact with the salvia miltiorrhiza, and the salvia miltiorrhiza is squeezed by the silicone cleaning convex points of the silicone cleaning sleeve (7).

8. The preparation device of Shexiang Tongxin Dropping Pills according to claim 7, characterized in that: The top surfaces at both ends of the cleaning screen frame (11) are welded with inverted support ear plates (21), and the horizontal bottom surface of each support ear plate (21) is symmetrically welded with two positioning uprights (23). The four positioning uprights (23) are arranged in groups of two, and the two groups are symmetrically distributed on both sides of the medicine washing pool (3), so that each positioning upright (23) is located outside the medicine washing pool (3) and is longitudinally inserted into the medicine washing tank box (2).

9. The preparation device of Shexiang Tongxin Dropping Pills according to claim 8, characterized in that: The vibrating material turning mechanism comprises a rotating shaft (29) rotatably mounted between two vertical plates (27), an eccentric wheel disc (26) symmetrically fixed to both ends of the circumference of the rotating shaft (29), and a second servo motor (28) fixed to the outer wall of one of the vertical plates (27).

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