Traditional Chinese medicine external preparation for skin antibiosis, cleaning and nursing

Abstract

The invention discloses a traditional Chinese medicine external preparation for skin antibiosis, cleaning and nursing, and belongs to the technical field of traditional Chinese medicine compositions. The preparation comprises the following raw materials: amur corktree bark, baical skullcap root and other traditional Chinese medicinal materials, chlorhexidine acetate, a proper amount of ethanol and the like. By scientifically adjusting the dosage of the medicinal materials, the formula is more reasonable, and is more efficient in bacteriostasis and cleaning compared with the original formula. Chlorhexidine acetate relieves irritation to skin mucous membranes, widens the antibacterial range and can inhibit staphylococcus aureus, escherichia coli, candida albicans and the like. Meanwhile, ethanol consumption is reduced, and skin irritation and potential safety hazards are reduced. The natural, mild and multi-target effect advantages of traditional Chinese medicines are reserved, the synergistic effect of a compound preparation is achieved, the skin function can be adjusted, and the resistance can be enhanced. The antibacterial cleaning agent is suitable for various skin conditions, can be prepared into various dosage forms such as solutions and lotions, and has a wide application prospect in the field of antibacterial cleaning and nursing of skin.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine external preparation for skin antibacterial cleaning and care. Background Art

[0002] In today's society, as people's living standards continue to improve, they pay more and more attention to skin health and hygiene. As the largest organ in the human body, the skin is in direct contact with the external environment and is easily invaded by various pathogens, such as Staphylococcus aureus, Escherichia coli and Candida albicans. These pathogens can cause a variety of skin problems, such as inflammation, itching, ulcers, etc., which seriously affect people's quality of life.

[0003] At present, there are many kinds of products for skin antibacterial cleaning and care on the market, mainly including chemical synthetic preparations and traditional Chinese medicine preparations. Although chemically synthesized skin antibacterial cleaning products, such as chlorine-containing disinfectants and alcohol-based disinfectants, have strong bactericidal ability, they often have the problem of being highly irritating. Long-term use may damage the skin's barrier function, leading to adverse reactions such as dry skin and allergies. They are especially not suitable for people with sensitive skin or damaged skin.

[0004] Traditional Chinese medicine preparations are gradually gaining attention in the field of skin care due to their natural and mild characteristics. For example, Baizhi Qushi Lotion, as a common traditional Chinese medicine external preparation, has certain applications in skin cleansing and antibacterial. However, the traditional Baizhi Qushi Lotion formula still has certain limitations in terms of formulation rationality and efficacy, and needs to be further improved in terms of antibacterial range, skin irritation, and comprehensive care effects.

[0005] At the same time, some existing antibacterial skin cleaning and care products fail to fully consider the synergistic effects of various ingredients in their formula design, resulting in a single product efficacy that is difficult to meet people's needs for comprehensive skin care. Moreover, some products use a large amount of ingredients such as ethanol, which poses safety hazards such as volatility and flammability, causing inconvenience and potential risks to users.

[0006] Therefore, it is of great practical significance and market demand to develop a Chinese medicine external preparation for skin antibacterial cleaning and care that has a more reasonable formula, is safe and effective, has a wide antibacterial range, and can give full play to the synergistic effect of various ingredients. Based on the above background, the present invention optimizes and innovates on the basis of the formula of Baizhi Qushi Lotion, aiming to provide a Chinese medicine external preparation for skin antibacterial cleaning and care with better performance. Summary of the invention

[0007] The object of the present invention is to provide a traditional Chinese medicine external preparation for skin antibacterial cleaning and care, which has better antibacterial efficacy.

[0008] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0009] The present invention provides a traditional Chinese medicine composition, wherein the raw materials of the traditional Chinese medicine composition include the following components in parts by weight:

[0010] 16-22 parts of Phellodendron amurense, 10-16 parts of Scutellaria baicalensis, 8-14 parts of Gardenia jasminoides, 6-12 parts of Scutellaria barbata, 4-10 parts of Oldenlandia diffusa, 14-20 parts of Honeysuckle vine, 8-14 parts of Houttuynia cordata, 6-12 parts of Kochia scoparia, 8-14 parts of Licorice, and 6-12 parts of Isatis indigotica.

[0011] The present invention also provides a traditional Chinese medicine external preparation, which comprises the traditional Chinese medicine composition, chlorhexidine acetate, ethanol and water.

[0012] Preferably, the final mass volume ratio concentration of the chlorhexidine acetate in the traditional Chinese medicine external preparation is 0.02% to 0.1%.

[0013] Preferably, the final volume percentage concentration of the ethanol in the traditional Chinese medicine external preparation is 5% to 15%.

[0014] Preferably, the method for preparing the Chinese medicine composition in the Chinese medicine external preparation comprises the following steps:

[0015] All raw materials are mixed with water and boiled to obtain the traditional Chinese medicine composition.

[0016] Preferably, the weight of the water is 5 to 10 times the weight of all raw materials;

[0017] The decocting time is 2 to 3 hours.

[0018] Preferably, the dosage form of the Chinese medicine external preparation is selected from a solution, a lotion, an ointment, a spray or a film-coating.

[0019] Preferably, the external Chinese medicine preparation further comprises pharmaceutically acceptable excipients, wherein the excipients are selected from one or more of a solubilizer, a co-solvent, a preservative, a stabilizer, a pH regulator or a moisturizer.

[0020] Preferably, the solubilizing agent is selected from one or more of polysorbate, poloxamer or polyoxyethylene castor oil;

[0021] The cosolvent is selected from one or more of ethanol, propylene glycol or glycerol;

[0022] The preservative is selected from one or more of sodium benzoate, potassium sorbate, methylparaben, ethylparaben or chlorobutanol;

[0023] The stabilizer is selected from one or more of disodium edetate, citric acid or tartaric acid;

[0024] The pH regulator is selected from one or more of hydrochloric acid, sodium hydroxide, disodium hydrogen phosphate or sodium dihydrogen phosphate;

[0025] The moisturizing agent is selected from one or more of glycerol, propylene glycol, sorbitol or polyethylene glycol.

[0026] The present invention also provides the use of the above-mentioned Chinese medicine composition or the above-mentioned Chinese medicine external preparation in the preparation of a skin antibacterial cleaning and care agent.

[0027] Beneficial effects of the present invention:

[0028] The Chinese medicine external preparation formula of the present invention is scientifically increased, decreased and optimized on the basis of the Baizhi Qushi lotion formula, so that the prescription is more reasonable. The dosage of each Chinese herbal medicine is carefully adjusted, and the synergistic effect of each other is exerted to give full play to the efficacy of the medicinal materials. Compared with the original formula, it is more efficient in terms of antibacterial and cleaning, and can better realize the care and health protection of the skin. By adding chlorhexidine acetate, the stimulation of the preparation to the patient's skin and mucous membrane is effectively reduced. This characteristic makes the preparation more applicable, not only suitable for daily cleaning and antibacterial of healthy skin, but also more friendly to people with sensitive skin or in a damaged state, and improves the safety and comfort of use. The addition of chlorhexidine acetate significantly increases the antibacterial range of the preparation. In addition to the inhibitory effect of Chinese medicine itself on some pathogens, chlorhexidine acetate can have a good inhibitory effect on common pathogens such as Staphylococcus aureus, Escherichia coli and Candida albicans, thereby more comprehensively ensuring the hygiene of the human skin surface and reducing the skin problems caused by pathogenic bacteria infection. Under the premise of ensuring the efficacy of the preparation, the present invention reduces the dosage of ethanol. Although ethanol has a certain bactericidal effect, excessive use may cause adverse effects such as dryness and irritation to the skin. The present invention reduces the amount of ethanol used, avoids these problems to a certain extent, makes the preparation less irritating to the skin, is more beneficial to skin health, and also reduces the potential safety hazards caused by ethanol volatilization.

[0029] The Chinese medicine external preparation provided by the present invention contains a variety of Chinese medicinal materials, such as Phellodendron chinense, Scutellaria baicalensis, Gardenia jasminoides, etc., which fully retains the characteristics of Chinese medicine. Chinese medicinal ingredients have the advantages of natural, mild, multi-target action, etc., which can not only directly act on pathogens, but also regulate the physiological functions of the skin, enhance the resistance of the skin itself, and achieve the effect of treating both the symptoms and the root causes, which is in line with the overall concept of traditional Chinese medicine and the concept of syndrome differentiation and treatment. The present invention scientifically matches a variety of Chinese medicinal materials with ingredients such as chlorhexidine acetate to form a compound preparation. This compound form gives full play to the synergistic effect of each component, and its efficacy is more comprehensive and efficient compared to a single component preparation. At the same time, the compound preparation can play a role of comprehensive treatment and protection for different types of skin problems and pathogens, reflecting the unique advantages of the compound preparation in skin care and antibacterial.

[0030] In summary, the Chinese medicine external preparation of the present invention has outstanding beneficial effects in terms of formula, safety, antibacterial performance, ingredient usage and treatment concept, and has broad application prospects and market value. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 Product test report prepared for Example 1①

[0032] Figure 2 Product test report ② prepared for Example 1;

[0033] Figure 3 Product test report prepared for Example 1③;

[0034] Figure 4 Product test report prepared for Example 1④;

[0035] Figure 5 Product test report prepared for Example 1⑤;

[0036] Figure 6 Product test report ⑥ prepared for Example 1;

[0037] Figure 7 Product test report ⑦ prepared for Example 1;

[0038] Figure 8 Product test report prepared for Example 1⑧;

[0039] Fig. 9 Product test report prepared for Example 1 ⑨;

[0040] Fig.10 Product test report prepared for Example 1 (10);

[0041] Fig.11 Product test report prepared for Example 1

[0042] Fig.12 Product test report prepared for Example 1 DETAILED DESCRIPTION

[0043] The present invention provides a traditional Chinese medicine composition, wherein the raw materials of the traditional Chinese medicine composition include the following components in parts by weight:

[0044] 16-22 parts of Phellodendron, 10-16 parts of Scutellaria, 8-14 parts of Gardenia, 6-12 parts of Scutellaria barbata, 4-10 parts of Hedyotis diffusa, 14-20 parts of Honeysuckle, 8-14 parts of Houttuynia, 6-12 parts of Kochia scoparia, 8-14 parts of Licorice, 6-12 parts of Isatis, and more preferably 18-20 parts of Phellodendron, 12-14 parts of Scutellaria, 10-12 parts of Gardenia, 8-10 parts of Scutellaria barbata, 6-8 parts of Hedyotis diffusa, 16-18 parts of Honeysuckle, 10-12 parts of Houttuynia , 8-10 parts of Kochia scoparia, 10-12 parts of licorice, 8-10 parts of Isatis root, further preferably 18.5-19.5 parts of Phellodendron chinense, 12.5-13.5 parts of Scutellaria baicalensis, 10.5-11.5 parts of Gardenia jasminoides, 8.5-9.5 parts of Scutellaria barbata, 6.5-7.5 parts of Oldenlandia diffusa, 16.5-17.5 parts of Honeysuckle, 10.5-11.5 parts of Houttuynia cordata, 8.5-9.5 parts of Kochia scoparia, 10.5-11.5 parts of licorice, and 8.5-9.5 parts of Isatis root.

[0045] The present invention also provides a traditional Chinese medicine external preparation, which comprises the above-mentioned traditional Chinese medicine composition, chlorhexidine acetate, ethanol and water. Preferably, the final mass volume ratio concentration of the chlorhexidine acetate in the traditional Chinese medicine external preparation is 0.02% to 0.1%, more preferably 0.04% to 0.08%, and even more preferably 0.05% to 0.07%.

[0046] Preferably, the final volume percentage concentration of the ethanol in the traditional Chinese medicine external preparation is 5% to 15%, more preferably 8% to 12%, and even more preferably 9% to 11%.

[0047] Preferably, the preparation method of the Chinese medicine composition in the Chinese medicine external preparation comprises the following steps: mixing all raw materials with water and boiling them to obtain the Chinese medicine composition.

[0048] Preferably, the weight of the water is 5 to 10 times the weight of all raw materials, more preferably 7 to 9 times, and even more preferably 7.5 to 8.5 times; the decoction time is 2 to 3 hours, more preferably 2.2 to 2.8 hours, and even more preferably 2.4 to 2.6 hours.

[0049] Preferably, the dosage form of the Chinese medicine external preparation is selected from a solution, lotion, liniment, spray or film-coating, more preferably a lotion or a spray, and even more preferably a lotion with a mild and cleansing formula, or a spray with a fine and uniform atomization effect.

[0050] Preferably, the Chinese medicine external preparation further includes a pharmaceutically acceptable excipient, which is selected from one or more of a solubilizer, a cosolvent, a preservative, a stabilizer, a pH regulator or a moisturizer. Further preferably, the solubilizer is selected from one or more of polysorbate, poloxamer or polyoxyethylene castor oil, and more preferably a mixture of polysorbate-80 and poloxamer 188 in a weight ratio of 1: (0.8-1.2); the cosolvent is selected from one or more of ethanol, propylene glycol or glycerol, and more preferably a mixture of ethanol and propylene glycol in a volume ratio of (1:1.5) to (1:0.5); the preservative is selected from one or more of sodium benzoate, potassium sorbate, methylparaben, ethylparaben or chlorobutanol, and more preferably a mixture of sodium benzoate and potassium sorbate in a weight ratio of (1:1.5) to (1:0.5); The stabilizer is selected from one or more of disodium edetate, citric acid or tartaric acid, and is more preferably a mixture of disodium edetate and citric acid in a weight ratio of (1:1.2) to (1:0.8); the pH adjuster is selected from one or more of hydrochloric acid, sodium hydroxide, disodium hydrogen phosphate or sodium dihydrogen phosphate, and is more preferably a mixture of disodium hydrogen phosphate and sodium dihydrogen phosphate in a weight ratio of (1:1.2) to (1:0.8) for adjusting the pH value to an appropriate range; the humectant is selected from one or more of glycerol, propylene glycol, sorbitol or polyethylene glycol, and is more preferably a mixture of glycerol and propylene glycol in a volume ratio of (1:1.5) to (1:0.5).

[0051] The present invention also provides the use of the above-mentioned Chinese medicine composition or the above-mentioned Chinese medicine external preparation in the preparation of a skin antibacterial cleaning and care agent.

[0052] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0053] Example 1

[0054] Preparation prescription: Phellodendron 20g, Scutellaria 12g, Gardenia 12g, Scutellaria barbata 8g, Oldenlandia diffusa 8g, Honeysuckle 16g, Houttuynia cordata 10g, Kochia scoparia 10g, Licorice 10g, Isatis root 10g.

[0055] Select the prescribed medicinal materials to remove impurities, add 10 times the amount of water and boil for 3 hours, filter out the decoction, cool to room temperature, add 0.5g of chlorhexidine acetate, 90g of 95% ethanol, and then add purified water to adjust to 1000mL, mix well, and fill.

[0056] Example 2

[0057] Preparation prescription: Phellodendron 22g, Scutellaria 10g, Gardenia 14g, Scutellaria barbata 10g, Oldenlandia diffusa 6g, Honeysuckle 14g, Houttuynia cordata 12g, Kochia scoparia 8g, Licorice 12g, Isatis root 8g.

[0058] Select the prescribed medicinal materials to remove impurities, add 8 times the amount of water and boil for 2.5 hours, filter out the decoction, cool to room temperature, add 0.4g of chlorhexidine acetate, 100g of 95% ethanol, and then add purified water to adjust to 1000mL, mix well, and fill.

[0059] Example 3

[0060] Preparation prescription: Phellodendron 18g, Scutellaria baicalensis 14g, Gardenia 10g, Scutellaria barbata 6g, Oldenlandia diffusa 10g, Honeysuckle 18g, Houttuynia cordata 8g, Kochia scoparia 12g, Licorice 8g, Isatis indigotica 12g.

[0061] Select the prescribed medicinal materials to remove impurities, add 12 times the amount of water and boil for 3.5 hours, filter out the decoction, cool to room temperature, add 0.6g of chlorhexidine acetate, 80g of 95% ethanol, and then add purified water to adjust to 1000mL, mix well, and fill.

[0062] Example 4

[0063] Preparation prescription: Phellodendron 20g, Scutellaria 12g, Gardenia 12g, Scutellaria barbata 8g, Oldenlandia diffusa 8g, Honeysuckle 16g, Houttuynia cordata 10g, Kochia scoparia 10g, Licorice 10g, Isatis root 10g.

[0064] Select the prescribed medicinal materials to remove impurities, add 9 times the amount of water and boil for 2 hours, filter out the decoction, cool to room temperature, add 0.3g of chlorhexidine acetate, 110g of 95% ethanol, and then add purified water to adjust to 1000mL, mix well, and fill.

[0065] Example 5

[0066] Preparation prescription

[0067] Phellodendron 16g, Scutellaria baicalensis 16g, Gardenia jasminoides 8g, Scutellaria barbata 12g, Oldenlandia diffusa 4g, Honeysuckle 20g, Houttuynia cordata 14g, Kochia scoparia 6g, Licorice 14g, Isatis indigotica 6g.

[0068] Select the prescribed medicinal materials to remove impurities, add 11 times the amount of water and boil for 4 hours, filter out the decoction, cool to room temperature, add 0.7g of chlorhexidine acetate, 70g of 95% ethanol, and then add purified water to adjust to 1000mL, mix well, and fill.

[0069] Experimental example

[0070] The product prepared in Example 1 was subjected to an antibacterial performance test conducted by Guizhou Medical University, and it was shown that it had a strong inhibitory effect on Staphylococcus aureus, Escherichia coli and Candida albicans. Figures 1 to 12 . Stability tests indicate that it still has good antibacterial effects within the one-year shelf life, and multiple complete skin irritation tests have confirmed that it is non-irritating. It complies with the relevant provisions of the Ministry of Health's "Technical Specifications for Disinfection" (2002 edition) and GB38456-2020 "Requirements for Antibacterial and Antibacterial Lotions".

[0071] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition, characterized in that: The raw materials of the Chinese medicine composition include the following components in parts by weight: 16-22 parts of Phellodendron amurense, 10-16 parts of Scutellaria baicalensis, 8-14 parts of Gardenia jasminoides, 6-12 parts of Scutellaria barbata, 4-10 parts of Oldenlandia diffusa, 14-20 parts of Honeysuckle vine, 8-14 parts of Houttuynia cordata, 6-12 parts of Kochia scoparia, 8-14 parts of Licorice, and 6-12 parts of Isatis indigotica.

2. A Chinese medicine external preparation, characterized in that: The traditional Chinese medicine external preparation comprises the traditional Chinese medicine composition according to claim 1, chlorhexidine acetate, ethanol and water.

3. The Chinese medicine external preparation according to claim 2, characterized in that: The final mass volume ratio concentration of the chlorhexidine acetate in the traditional Chinese medicine external preparation is 0.02% to 0.1%.

4. The Chinese medicine external preparation according to claim 2, characterized in that: The final volume percentage concentration of the ethanol in the traditional Chinese medicine external preparation is 5% to 15%.

5. The Chinese medicine external preparation according to claim 2, characterized in that: The preparation method of the Chinese medicine composition in the Chinese medicine external preparation comprises the following steps: All raw materials are mixed with water and boiled to obtain the traditional Chinese medicine composition.

6. The Chinese medicinal preparation for external use according to claim 5, characterized in that: The weight of the water is 5 to 10 times the weight of all raw materials; The decocting time is 2 to 3 hours.

7. The Chinese medicine external preparation according to claim 2, characterized in that: The dosage form of the traditional Chinese medicine external preparation is selected from solution, lotion, liniment, spray or film coating.

8. The Chinese medicinal preparation for external use according to claim 7, characterized in that: The traditional Chinese medicine external preparation also includes pharmaceutically acceptable excipients, which are selected from one or more of solubilizers, cosolvents, preservatives, stabilizers, pH regulators or moisturizers.

9. The Chinese medicinal preparation for external use according to claim 8, characterized in that: The solubilizing agent is selected from one or more of polysorbate, poloxamer or polyoxyethylene castor oil; The cosolvent is selected from one or more of ethanol, propylene glycol or glycerol; The preservative is selected from one or more of sodium benzoate, potassium sorbate, methylparaben, ethylparaben or chlorobutanol; The stabilizer is selected from one or more of disodium edetate, citric acid or tartaric acid; The pH regulator is selected from one or more of hydrochloric acid, sodium hydroxide, disodium hydrogen phosphate or sodium dihydrogen phosphate; The moisturizing agent is selected from one or more of glycerol, propylene glycol, sorbitol or polyethylene glycol.

10. Use of the Chinese medicine composition according to claim 1 or the Chinese medicine external preparation according to any one of claims 2 to 9 in the preparation of an antibacterial skin cleaning and care agent.

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