Traditional Chinese medicine composition for tonifying qi and enhancing immunity for children as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention belongs to the technical field of medicinal and edible health-care food, and particularly relates to a traditional Chinese medicine composition for tonifying qi and enhancing immunity for children as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 5 to 10 parts of radix codonopsis, 10 to 20 parts of radix fici simplicissimae, 10 to 20 parts of poria cocos, 10 to 20 parts of malt and 10 to 20 parts of fructus mume. Through ingenious compatibility, the monarch drug codonopsis pilosula and the ministerial drug radix fici simplicissimae are matched with each other to tonify spleen, tonify qi and regulate the immune function of a body, meanwhile, poria cocos, malt and smoked plum are matched to tonify spleen, promote digestion and nourish yin, moistening and dryness are matched in the whole formula, and the traditional Chinese medicine has the effects of tonifying spleen, tonifying lung, nourishing without obstructing spleen and stomach and warming without dryness to tonify qi and increase immunity. Clinical research finds that the traditional Chinese medicine composition for tonifying qi and enhancing immunity for children can obviously improve clinical symptoms of children patients with recurrent respiratory tract infection.

Description

Technical Field

[0001] The invention belongs to the technical field of health-care foods with medicinal and edible properties, and particularly relates to a traditional Chinese medicine composition for replenishing qi and improving immunity for children, and a preparation method and application thereof. Background Art

[0002] Recurrent respiratory tract infection (RRTI) in children refers to a clinical disease in which the number of upper or lower respiratory tract infections increases and exceeds the normal limit within one year. In pediatric outpatient clinics in my country, the proportion of children who visit for respiratory diseases is about 80%, of which RRTI accounts for more than 50%. Children have poor resistance and their body functions have not yet matured. RRTI lasts for a long time and the condition recurs. If the clinical treatment is not thorough, it is easy to cause multi-system diseases such as asthma, nephritis, myocarditis, and meningitis, which will seriously affect the physical health and growth and development of children, and even increase the risk of chronic heart and lung diseases in children in adulthood. Immunomodulators are the basic clinical drugs for RRTI. The most commonly used drugs include spleen aminopeptide, pidotimod, and panfossil. However, these drugs are not only expensive, but also prone to recurrence of symptoms after discontinuation of medication.

[0003] In recent years, with the accumulation of clinical evidence, the treatment of RRTI with traditional Chinese medicine has gradually been valued. Although there are some traditional Chinese medicines used to treat RRTI in clinical practice, the clinical effects of these traditional Chinese medicines are not very satisfactory. Therefore, it is necessary to develop a traditional Chinese medicine composition that can effectively prevent and treat RRTI to meet the daily defense needs of children. Summary of the invention

[0004] The first purpose of the present invention is to provide a traditional Chinese medicine composition for replenishing qi and increasing immunity in children. The second purpose of the present invention is to provide a method for preparing the traditional Chinese medicine composition. The third purpose of the present invention is to provide an application of the traditional Chinese medicine composition.

[0005] According to the first aspect of the present invention, a traditional Chinese medicine composition for replenishing qi and improving immunity for children is provided, wherein the raw materials thereof comprise, by weight: 5-10 parts of Codonopsis pilosula, 10-20 parts of Prunus quinata, 10-20 parts of Poria cocos, 10-20 parts of malt, and 10-20 parts of Black Plum.

[0006] The present invention believes that most children with recurrent respiratory tract infections are in a state of immune imbalance, which is mainly manifested by recurrent colds, pharyngitis, tracheitis, and pneumonia. Therefore, based on the pathogenesis and clinical manifestations, the method of TCM syndrome differentiation and treatment is adopted to propose the prescription of the present invention.

[0007] In the formula, Codonopsis pilosula is used to nourish the Qi of the lungs and spleen, and is the main drug in the formula. Prunus mume can also nourish the spleen and nourish the lungs, and is the minister drug. The two complement each other, greatly nourish the Qi of the lungs and spleen, and jointly regulate the body's immune function. Poria strengthens the spleen, replenishes Qi and eliminates dampness, malt strengthens the spleen and helps digestion, and black plum nourishes Yin and stimulates appetite, removes phlegm, quenches thirst, regulates the middle, and collects lung Qi. The combination of these drugs can not only strengthen the spleen and nourish the lungs, but also help digestion and harmonize the middle, so as not to over-tonify and stagnate the Qi of the lungs and spleen. Black plum can also nourish Yin and moisten dryness, and avoid Codonopsis pilosula from being too warm and dry. The whole formula is used together to play the effect of replenishing Qi and increasing immunity, which can well improve the clinical symptoms of children with recurrent respiratory tract infections.

[0008] The sources of raw materials for this recipe are as follows:

[0009] Codonopsis: The root of Codonopsis pilosula (Franch.) Nannf., C.pilosula Nannf.var. (Nannf.) LTShen or C.tangshen Oliv. of the Campanulaceae family.

[0010] Five-fingered ginseng: the root of Ficus simplicissima Lour., a plant of the Moraceae family.

[0011] Poria: The dried sclerotium of the fungus Poriacocos (Schw.) Wolf of the Polyporaceae family.

[0012] Malt: Malt is made by germinating and drying the ripe fruits of Hordeum vulgare L., a plant of the Poaceae family.

[0013] Black plum: the nearly ripe fruit of Prunus mume (Sieb.) Sieb.et Zuce., a plant of the genus Prunus in the Rosaceae family.

[0014] The raw materials of the Chinese medicine composition of the present invention, namely, Codonopsis pilosula, Poria cocos, malt and black plum, are substances that are "both food and Chinese medicinal materials", and the quinquefolius is a common food. The raw materials of the formula are all Chinese medicinal materials that can be used for health food, and their sources are safe and reliable.

[0015] In some embodiments, the dosage form of the Chinese medicine composition is an oral solution, powder or granule.

[0016] In some embodiments, excipients acceptable in the food field or pharmaceutically can also be added.

[0017] In some embodiments, the auxiliary material is at least one of a sustained-release agent, an excipient, a filler, a binder, a wetting agent, a disintegrant, an absorption enhancer, an adsorption carrier, a surfactant, and a lubricant.

[0018] According to a second aspect of the present invention, a method for preparing the above-mentioned Chinese medicine composition for replenishing qi and increasing immunity for children is provided. When the dosage form of the Chinese medicine composition is an oral solution, the preparation method comprises the following steps:

[0019] The raw material is added into 8-12 times of water by weight and soaked for 20-40 minutes, then heated to boiling, kept slightly boiling for 1-2 hours, filtered, and the residue is repeatedly decocted 1-2 times, and the filtrate is combined to obtain the oral solution. After the oral solution is cooled, it is also packaged, so that it is easy to carry and distribute.

[0020] According to a third aspect of the present invention, a method for preparing the above-mentioned Chinese medicine composition for replenishing qi and increasing immunity for children is provided. When the dosage form of the Chinese medicine composition is a powder, the preparation method comprises the following steps:

[0021] The raw materials are crushed or chopped separately, and then the crushed or chopped raw materials are passed through 10-mesh and 50-mesh sieves respectively, and the coarse particles that cannot pass through the 10-mesh sieve are further crushed or chopped, and the powder between the 10-mesh sieve and the 50-mesh sieve is taken, and then the raw material powders are mixed according to the proportion, put into the packaging bag, and sealed.

[0022] According to a fourth aspect of the present invention, there is provided a use of the above-mentioned traditional Chinese medicine composition for replenishing qi and increasing immunity in children in the preparation of a medicine-food composition for improving or preventing and treating recurrent respiratory tract infections in children.

[0023] According to the fifth aspect of the present invention, there is provided the use of the above-mentioned traditional Chinese medicine composition for replenishing qi and improving immunity for children in the preparation of a health product of both medicinal and edible properties for improving the body's immune function and / or preventing and treating colds, pharyngitis, tracheitis or pneumonia.

[0024] The beneficial effects of the present invention include:

[0025] (1) The Chinese medicine composition for replenishing qi and increasing immunity for children of the present invention can effectively improve the immune imbalance state of children with recurrent respiratory tract infections, enhance the body's immune function, and reduce the frequency of colds, pharyngitis, tracheitis, pneumonia and recurrent respiratory tract infections.

[0026] (2) The present invention cleverly combines the main drug Codonopsis pilosula and the auxiliary drug Eleutherodactyl quinquefolius to strengthen the spleen and replenish qi, and regulate the body's immune function. At the same time, it is combined with Poria cocos, malt, and black plum to strengthen the spleen, promote digestion, and nourish yin. The whole formula combines moistening and drying properties. While strengthening the spleen and replenishing the lungs, it nourishes without hindering the spleen and stomach, and is warm without being dry, so as to achieve the effect of replenishing qi and increasing immunity. Clinical studies have found that the Chinese medicine composition for replenishing qi and increasing immunity for children of the present invention can significantly improve the clinical symptoms of children with recurrent respiratory tract infections. DETAILED DESCRIPTION

[0027] The present invention is further described in detail below in conjunction with specific embodiments. It is worth noting that the following embodiments are only for better explanation of the present invention and are not intended to limit the scope of protection of the present invention. The undisclosed process steps in the embodiments are prior art. Unless otherwise specified, the following raw materials are commercially available.

[0028] Example 1

[0029] The oral solution for replenishing qi and increasing immunity for children in this embodiment is composed of the following raw materials: 5g of Codonopsis pilosula, 10g of Prunus mume, 10g of Poria cocos, 10g of malt, and 10g of Prunus mume.

[0030] The preparation method comprises the following steps:

[0031] (1) Add 10 times the weight of the raw material to water and soak for 30 minutes, then heat to boiling and keep it slightly boiling for 1 hour, and separate to obtain a first decoction and a medicinal residue; take the medicinal residue obtained after the first decoction, add 8 times the weight of water equivalent to the total mass of the raw material, heat to boiling, keep it slightly boiling for 1 hour, and separate to obtain a second decoction and a medicinal residue; combine the first decoction and the second decoction to obtain an oral solution.

[0032] (2) Cool the obtained oral solution and then package it. The ratio is one dose, and one dose is about 150 mL.

[0033] Example 2

[0034] The powder for replenishing qi and increasing immunity for children of the present embodiment is composed of the following raw materials: 5g of Codonopsis pilosula, 10g of Prunus mume, 10g of Poria cocos, 10g of malt, and 10g of Plum.

[0035] The preparation method comprises the following steps:

[0036] (1) Take Codonopsis pilosula, crush it, and pass it through 10-mesh and 50-mesh sieves at the same time. Continue to crush the coarse particles that cannot pass through the 10-mesh sieve, and take the powder between the 10-mesh sieve and the 50-mesh sieve;

[0037] (2) crushing the five-fingered peach, Poria cocos, malt, and black plum into powder according to the method of step (1);

[0038] (3) Mix all the raw material powders evenly, put them into a packaging bag, and seal it. When taking it, take it with about 150 mL of warm water.

[0039] Example 3

[0040] The oral solution for replenishing qi and increasing immunity for children of the present embodiment is composed of the following raw materials: 7g of Codonopsis pilosula, 15g of Prunus mume, 15g of Poria cocos, 15g of malt, and 15g of Prunus mume.

[0041] The preparation method is the same as that of Example 1.

[0042] Example 4

[0043] The powder for replenishing qi and increasing immunity for children of the present embodiment is composed of the following raw materials: 10g of Codonopsis pilosula, 20g of Prunus mume, 20g of Poria cocos, 20g of malt, and 20g of Plum.

[0044] The preparation method is the same as that of Example 2.

[0045] The oral solution for children's qi replenishment and immunity prepared in Example 1 was used for children with recurrent respiratory tract infections. The gender, age, symptom information and follow-up symptom information of 30 children with recurrent respiratory tract infections from August 5, 2024 to August 30, 2024 were collected, and their main symptoms were scored. The 30 children with recurrent respiratory tract infections were aged 2-14 years old, with an average age of 7.35 years old, including 19 males and 11 females. The main symptoms before taking the medicine included nasal congestion, coughing, sneezing, sweating, fatigue, poor appetite, etc. The symptoms of 30 children with recurrent respiratory tract infections before and after taking the Children's Qi-boosting and Zengmian oral solution were compared. The results showed that the average scores of symptom scores of nasal congestion, cough, sneezing, sweating, fatigue, and poor appetite after taking the oral solution of the present invention were lower than those before taking it (Table 1), indicating that taking the Children's Qi-boosting and Zengmian oral solution is significantly effective in alleviating or improving the symptoms of nasal congestion, cough, sneezing, sweating, fatigue, and poor appetite caused by recurrent respiratory tract infections in children (P<0.05).

[0046] The research results indicate that the Chinese medicine composition of the present invention has a good effect in improving the symptoms of nasal congestion, cough, sneezing, excessive sweating, fatigue, poor appetite, etc. caused by recurrent respiratory tract infections in children. This indicates that the Chinese medicine composition of the present invention has a good improvement effect on recurrent respiratory tract infections in children.

[0047] Table 1 Statistical analysis of the effect of children's Buqi Zengmian oral solution on the symptoms of children with recurrent respiratory tract infections (x±s)

[0048] Nasal congestion cough sneeze Sweat a lot Fatigue Poor appetite Initial diagnosis score 2.13±0.51 2.07±0.83 1.83±0.70 2.67±0.84 1.80±0.71 2.17±0.91 Follow-up score 1.62±0.49 1.41±0.50 1.47±0.57 1.60±0.58 1.21±0.50 1.31±0.47 P-value <0.001 0.001 0.005 <0.001 <0.001 <0.001

[0049] The above are only some specific embodiments of the present invention. For those skilled in the art, several modifications and improvements can be made without departing from the creative concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A Chinese medicine composition for replenishing qi and increasing immunity for children, characterized in that: The raw material composition comprises, by weight, 5-10 parts of codonopsis pilosula, 10-20 parts of quinquefolius, 10-20 parts of tuckahoe, 10-20 parts of malt, and 10-20 parts of black plum.

2. The Chinese medicine composition for replenishing qi and increasing immunity for children according to claim 1, characterized in that: The dosage form of the Chinese medicine composition is oral solution, powder or granule.

3. The Chinese medicine composition for replenishing qi and increasing immunity for children according to claim 1 or 2, characterized in that: Pharmaceutically acceptable excipients may also be added.

4. The Chinese medicine composition for replenishing qi and increasing immunity for children according to claim 3, characterized in that: The auxiliary material is at least one of a sustained-release agent, an excipient, a filler, a binder, a wetting agent, a disintegrant, an absorption promoter, an adsorption carrier, a surfactant, and a lubricant.

5. The method for preparing the Chinese medicine composition for replenishing qi and increasing immunity for children according to any one of claims 1 to 4, characterized in that: When the dosage form of the Chinese medicine composition is an oral solution, the preparation method thereof comprises the following steps: The raw material is added into 8-12 times of the weight of water and soaked for 20-40 minutes, then heated to boiling, kept slightly boiling for 1-2 hours, filtered, and the filter residue is repeatedly decocted 1-2 times, and the filtrate is combined to obtain the product.

6. The method for preparing the Chinese medicine composition for replenishing qi and increasing immunity for children according to any one of claims 1 to 4, characterized in that: When the dosage form of the Chinese medicine composition is a powder, the preparation method thereof comprises the following steps: The raw materials are crushed or chopped separately, and then the crushed or chopped raw materials are passed through 10-mesh and 50-mesh sieves respectively, and the coarse particles that cannot pass through the 10-mesh sieve are further crushed or chopped, and the powder between the 10-mesh sieve and the 50-mesh sieve is taken, and then the raw material powders are mixed according to the proportion, put into the packaging bag, and sealed.

7. Use of the traditional Chinese medicine composition for replenishing qi and increasing immunity for children as claimed in any one of claims 1 to 4 in the preparation of a health product of medicinal and edible nature for improving or preventing and treating recurrent respiratory tract infections in children.

8. Use of the traditional Chinese medicine composition for replenishing qi and improving immunity for children as claimed in any one of claims 1 to 4 in the preparation of a health product of medicinal and edible properties for improving immune function and / or preventing and treating colds, pharyngitis, tracheitis or pneumonia.