Traditional Chinese medicine composition for treating liver-kidney yin deficiency type femoral head necrosis as well as preparation method and application thereof

Abstract

The invention relates to a traditional Chinese medicine composition for treating liver-yin and kidney-yin deficiency type femoral head necrosis as well as a preparation method and application of the traditional Chinese medicine composition, and can effectively solve the medication problem of the liver-yin and kidney-yin deficiency type femoral head necrosis. The traditional Chinese medicine is prepared from the following raw material medicines by weight: 15-25 g of Chinese yam, 10-20 g of pulp of dogwood fruit, 8-16 g of prepared rehmannia root, 6-12 g of semen cuscutae, 6-14 g of vinegar tortoise shell, 6-14 g of vinegar turtle shell, 10-20 g of radix cyathulae, 8-16 g of glossy privet fruit, 8-16 g of fructus lycii, 6-14 g of fructus psoraleae, 6-12 g of polygonum multiflorum, 6-14 g of ligusticum wallichii, 6-12 g of vinegar rhizoma cyperi, 8-16 g of radix paeoniae alba, 6-14 g of vinegar curcuma zedoary, 6-14 g of vinegar rhizoma sparganii and 4-8 g of liquorice. The traditional Chinese medicine composition has the advantages of effective combination, mutual support and scientific preparation, has the effects of warming kidney yang, clearing damp and strengthening spleen, has a remarkable effect of treating the liver-kidney yin deficiency type femoral head necrosis, is good in long-term curative effect, is not easy to relapse, is easily accepted by patients, and is an innovation of medicines for treating the liver-kidney yin deficiency type femoral head necrosis.

Description

1. Technical Field

[0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition for treating liver-kidney yin deficiency type femoral head necrosis, a preparation method and application thereof. 2. Background Technology

[0002] Femoral head necrosis is a common clinical orthopedic disease. It is difficult to treat and disabling. It is a pathological evolution process. It often starts in the weight-bearing area of ​​the femoral head. Under the action of force, the necrotic bone structure is damaged, resulting in repeated imperfect repair, resulting in changes in the femoral head structure or collapse and deformation. Femoral head necrosis will cause severe pain and joint mobility dysfunction in patients. Common clinical symptoms include pain, which is mostly located in the hip joint and proximal thigh, resulting in limited hip movement, especially limited rotational movement, or painful and shortened claudication, which seriously endangers the patient's quality of life and even life safety. The current incidence of ONFH is increasing year by year, seriously affecting the quality of life of patients and bringing a considerable economic burden to their families. Studies have shown that patients with ONFH who have not been effectively treated will experience femoral head collapse within 1 to 5 years of onset, which directly affects the function of the hip joint, and ultimately can only be improved through joint replacement surgery. At present, hip preservation treatment is mainly adopted for early and middle-stage ONFH at home and abroad to stabilize the morphology of the femoral head and delay collapse, thereby delaying the time for hip replacement surgery.

[0003] Femoral head necrosis belongs to the category of "bone atrophy" and "bone deficiency" in traditional Chinese medicine. "The kidney governs bones, the liver governs tendons, and bones produce marrow." Traditional Chinese medicine believes that the main causes of this disease are liver and kidney deficiency, insufficient qi and blood, lack of nourishment to tendons and bones, joint strain, cold and dampness, and blood stasis. The root cause of this disease is liver and kidney deficiency. This disease is prone to recurrence. For this reason, traditional Chinese medicine treatment advocates that this disease is mostly due to deficiency in the root and excess in the superficial, with a mixture of deficiency and excess, liver and kidney deficiency, and spleen and stomach dysfunction. The kidney-tonifying and bone-strengthening method has the effect of nourishing the liver and kidney and strengthening tendons and bones, and can effectively improve the symptoms of such patients. Chinese medicine combination can improve the Harris and JOA scores of patients with femoral head ischemic necrosis, relieve their pain, and is safer. Traditional Chinese medicine conservative treatment has unique therapeutic advantages in preventing and treating femoral head necrosis, and has an improving effect on blood rheology and blood lipids. We believe that femoral head necrosis is not single in terms of pathogenesis, and is related to multiple organs such as the liver, kidney, spleen, bladder, etc., but is most closely related to the liver and kidney. The kidney governs the bones, and treating bone diseases from the perspective of the kidney. It is in line with the theory of traditional Chinese medicine to take tonifying the kidney as the fundamental treatment goal to strengthen the tendons and bones. However, patients with liver and kidney yin deficiency are also part of the treatment in clinical work, but there are few existing studies on this. In view of this, we propose liver and kidney yin deficiency type femoral head necrosis, and invent a Chinese medicine composition for treating liver and kidney yin deficiency type femoral head necrosis. III. Summary of the invention

[0004] In view of the above situation, in order to solve the defects of the prior art, the purpose of the present invention is to provide a Chinese medicine composition for treating liver-kidney yin deficiency type femoral head necrosis, a preparation method and application, which can effectively solve the medication problem of liver-kidney yin deficiency type femoral head necrosis.

[0005] Femoral head necrosis of liver and kidney yin deficiency is characterized by a thin and long body, hot hands and soles, reddish complexion, dry eyes, slightly dry nose, dry mouth and throat. They like cold drinks, often have dry stools, can tolerate winter but not summer. They are also irritable, prone to insomnia, have a red tongue with little fluid and coating, and a weak and rapid pulse. Based on this, the technical solution solved by the present invention is a traditional Chinese medicine composition for treating liver-kidney yin deficiency type femoral head necrosis, which is made of the following raw materials by weight: 15-25g of yam, 10-20g of cornus, 8-16g of rehmannia root, 6-12g of dodder seed, 6-14g of vinegar tortoise shell, 6-14g of vinegar turtle shell, 10-20g of cyathula, 8-16g of glossy privet, 8-16g of wolfberry, 6-14g of psoralea corylifolia, 6-12g of polygonum multiflorum, 6-14g of chuanxiong, 6-12g of vinegar cyperus rotundus, 8-16g of white peony root, 6-14g of vinegar curcuma, 6-14g of vinegar trillium and 4-8g of liquorice.

[0006] Preferably, the Chinese medicine composition is made of the following raw materials by weight: 20g of yam, 15g of cornus fruit, 12g of rehmannia root, 9g of dodder seed, 10g of vinegar tortoise shell, 10g of vinegar turtle shell, 15g of cyathula, 12g of glossy privet fruit, 12g of wolfberry, 10g of psoralea corylifolia, 9g of polygonum multiflorum, 10g of chuanxiong, 9g of vinegar cyperus, 12g of white peony root, 9g of vinegar curcuma, 9g of vinegar trillium and 6g of liquorice.

[0007] Furthermore, a method for preparing a traditional Chinese medicine composition for treating liver-kidney yin deficiency type femoral head necrosis is provided, which is made into different dosage forms such as decoction, pills, tablets, granules, ointments, etc. with pharmaceutically acceptable excipients.

[0008] Furthermore, the preparation method of the water decoction is as follows: add 400-600 ml of water to the above raw material drugs, soak for 15-25 minutes at 18-25°C, then boil over high heat, then turn to low heat, boil for 20-30 minutes, filter, obtain filtrate, and set aside; add 300-400 ml of water to the filter residue, boil over high heat, then turn to low heat, boil for 10-15 minutes, filter, discard the filter residue, obtain filtrate, combine the two filtrates, and concentrate to 1 / 2-1 / 3 of the amount of water added twice.

[0009] Furthermore, the present invention provides an application of the Chinese medicine composition for treating liver-kidney yin deficiency type femoral head necrosis in the preparation of drugs for liver-kidney yin deficiency type femoral head necrosis.

[0010] The invention has abundant raw materials, simple preparation method, effective combination of prescription drugs, mutual support, and scientific preparation, and has the effects of warming kidney yang, removing dampness and strengthening spleen. It has significant effect in treating femoral head necrosis of liver-kidney yin deficiency type, and has good long-term efficacy, is not easy to recur, and is easily accepted by patients. It is an innovation in drugs for treating femoral head necrosis of liver-kidney yin deficiency type. 4. Specific implementation methods

[0011] The specific implementation modes of the present invention are further described in detail below in conjunction with the embodiments.

[0012] Example 1

[0013] When the present invention is implemented specifically, the Chinese medicine composition can be prepared from the following raw materials by weight: 15g of yam, 10g of cornus fruit, 8g of rehmannia root, 6g of dodder seed, 6g of vinegar tortoise shell, 6g of vinegar turtle shell, 10g of cyathula, 8g of glossy privet fruit, 8g of wolfberry fruit, 6g of psoralea corylifolia, 6g of polygonum multiflorum, 6g of ligusticum chuanxiong, 6g of vinegar cyperus rotundus, 8g of white peony root, 6g of vinegar curcuma, 6g of vinegar trillium and 4g of liquorice.

[0014] The preparation method is as follows: add 400 ml of water to the above raw material drugs, soak for 15 minutes at 18°C, then boil over high heat, then turn to low heat, boil for 20 minutes, filter, obtain filtrate, and set aside; add 300 ml of water to the residue, boil over high heat, then turn to low heat, boil for 10 minutes, filter, discard the residue, obtain filtrate, combine the two filtrates, and concentrate to 1 / 2 of the amount of water added twice.

[0015] Example 2

[0016] When the present invention is implemented, the Chinese medicine composition can also be made of the following raw materials by weight: 20g of yam, 15g of cornus fruit, 12g of rehmannia root, 9g of dodder seed, 10g of vinegar tortoise shell, 10g of vinegar turtle shell, 15g of cyathula, 12g of glossy privet fruit, 12g of wolfberry fruit, 10g of psoralea corylifolia, 9g of polygonum multiflorum, 10g of chuanxiong, 9g of vinegar cyperus rotundus, 12g of white peony root, 9g of vinegar curcuma, 9g of vinegar trillium and 6g of liquorice.

[0017] The preparation method is as follows: add 500 ml of water to the above raw material drugs, soak for 20 minutes at 21°C, then boil over high heat, then turn to low heat, boil for 25 minutes, filter, obtain the filtrate, and set aside; add 350 ml of water to the residue, boil over high heat, then turn to low heat, boil for 13 minutes, filter, discard the residue, obtain the filtrate, combine the two filtrates, and concentrate to 1 / 2 of the amount of water added twice.

[0018] Example 3

[0019] When the present invention is implemented, the Chinese medicine composition can also be made of the following raw materials by weight: 25g of yam, 20g of cornus fruit, 16g of rehmannia root, 12g of dodder seed, 14g of vinegar tortoise shell, 14g of vinegar turtle shell, 20g of cyathula, 16g of glossy privet fruit, 16g of wolfberry fruit, 14g of psoralea corylifolia, 12g of polygonum multiflorum, 14g of chuanxiong, 12g of vinegar cyperus rotundus, 16g of white peony root, 14g of vinegar curcuma, 14g of vinegar trillium and 8g of liquorice.

[0020] The preparation method is as follows: add 600 ml of water to the above raw material drugs, soak for 25 minutes at 25°C, then boil over high heat, then turn to low heat, boil for 30 minutes, filter, obtain filtrate, and set aside; add 400 ml of water to the residue, boil over high heat, then turn to low heat, boil for 15 minutes, filter, discard the residue, obtain filtrate, combine the two filtrates, and concentrate to 1 / 3 of the amount of water added twice.

[0021] In the prescription of the present invention:

[0022] Chinese yam is sweet and neutral in nature. It enters the spleen, lung and kidney meridians. It has the functions of replenishing qi and nourishing yin, tonifying spleen, lung and kidney, consolidating essence and stopping leukorrhea.

[0023] Fructus Corni is sour and astringent in taste, slightly warm in nature. It enters the liver and kidney meridians. It nourishes the liver and kidneys, astringes and consolidates the body.

[0024] Rehmannia root is sweet and slightly warm in nature. It enters the liver and kidney meridians. It nourishes blood and yin, replenishes essence and fills marrow.

[0025] Cuscuta chinensis tastes bitter and sweet, and is neutral in nature. It enters the liver and kidney meridians. It nourishes the kidney and improves the essence, nourishes the liver and improves eyesight.

[0026] Vinegar tortoise shell tastes sweet and is cold in nature. It enters the liver, kidney, and heart meridians. It nourishes yin and suppresses yang, and strengthens the kidneys and bones.

[0027] Vinegar turtle shell tastes salty and is slightly cold in nature. It enters the liver and kidney meridians. It nourishes yin and reduces fire, softens and disperses lumps.

[0028] Sichuan Cyathula is sweet, slightly bitter, and neutral in nature. It enters the liver and kidney meridians. It nourishes the liver and kidneys, strengthens tendons and bones, removes blood stasis, dredges the meridians, and guides blood downward.

[0029] Fructus Ligustri Lucidi tastes sweet and bitter, is cool in nature, and enters the liver and kidney meridians. It nourishes the liver and kidneys, clears away heat and improves eyesight.

[0030] Lycium barbarum is sweet and neutral in nature. It enters the liver and kidney meridians. It nourishes yin and kidneys, clears the liver and improves eyesight.

[0031] Psoralea corylifolia tastes pungent and bitter, and is warm in nature. It enters the spleen and kidney meridians. It nourishes the kidney and strengthens yang, warms the spleen and stops diarrhea, consolidates semen and reduces urine.

[0032] Polygonum multiflorum tastes bitter and astringent, and is slightly warm in nature. It enters the liver and kidney meridians. It nourishes the liver and kidneys, improves the essence and blood, and strengthens the tendons and bones.

[0033] Chuanxiong is pungent in taste and warm in nature. It enters the liver and gallbladder meridians. It promotes blood circulation, qi circulation, dispels wind and relieves pain.

[0034] Vinegar-scented angelica root tastes pungent and bitter, and is slightly warm in nature. It enters the liver, spleen, and kidney meridians. It soothes the liver and relieves depression, regulates qi, and relieves fullness.

[0035] White peony root tastes bitter, sour, and slightly cold. It enters the liver meridian. It calms liver yang, softens the liver and relieves pain, and nourishes yin and blood.

[0036] Vinegar Curcuma Atractylodes tastes pungent and bitter, and is warm in nature. It enters the liver and spleen meridians. It promotes qi and resolves blood, eliminates accumulation and relieves pain.

[0037] Vinegar Trigonum multiflorum tastes bitter and is neutral in nature. It enters the liver and spleen meridians. It can promote blood circulation, promote qi circulation, eliminate stagnation and relieve pain.

[0038] Licorice root is sweet and neutral in nature. It enters the spleen, stomach, heart and lung meridians. It nourishes the spleen and replenishes qi, relieves pain and harmonizes various medicines.

[0039] The effective combination of the above drugs supports each other and is scientifically prepared to nourish the liver and kidneys. Chinese yam and cornus fruit are used as the main drugs to nourish the liver and kidneys. Rehmannia root nourishes the liver and kidneys, replenishes the essence and fills the marrow. Cuscuta, Psoralea corylifolia, Cyathula officinalis, Ligustrum lucidum, and Lycium barbarum replenish the kidneys and replenish the essence. White peony root and Polygonum multiflorum are the ministerial drugs to nourish the yin and blood. The main and ministerial drugs cooperate to nourish the liver and kidneys. Vinegar tortoise shell and vinegar turtle shell nourish yin and suppress yang. Chuanxiong and vinegar Cyperus rotundus promote blood circulation and qi. Vinegar Trillium and vinegar Curcuma zedoaria promote qi and eliminate accumulation as adjuvant drugs, so that qi can be replenished without stagnation. Licorice relieves urgency and stops pain, and harmonizes the drugs as the guiding drug. The treatment of liver and kidney yin deficiency type femoral head necrosis has a significant effect, and has achieved very good beneficial technical effects through experiments. The relevant experimental data are as follows:

[0040] 1Case Source

[0041] This study selected 60 patients with femoral head necrosis of liver-kidney yin deficiency type who visited the Department of Osteonecrosis of Luoyang Orthopedic Hospital, Henan Province from January 2022 to October 2023 as the research subjects.

[0042] 2 Diagnostic criteria

[0043] The diagnostic criteria were developed based on the 2012 edition of the Expert Consensus on Diagnosis and Treatment Standards for Femoral Head Necrosis in Adults.

[0044] (1) Clinical symptoms, signs and medical history: joint pain mainly in the groin, buttocks and thighs, occasionally accompanied by knee pain, limited hip flexion, internal rotation and external rotation, often with a history of hip trauma, corticosteroid use, alcoholism and occupational history such as diving;

[0045] (2) X-ray changes: In the early stage of femoral head necrosis, the femoral head will show increased density (sclerosis) and translucent areas (cystic changes); as the disease progresses, a typical crescent sign will appear; in the late stage, the femoral head may collapse, the joint space may narrow, and severe bone and joint changes may occur, with sclerosis and cystic changes in the acetabulum being common;

[0046] (3) CT scan changes: sclerotic bands surrounding necrotic bone, repaired bone, or subchondral bone fractures can be seen in the femoral head;

[0047] (4) MRI signs: T1WI shows a band-like low signal in the necrotic area or T2WI shows a double-line sign;

[0048] (5) Radionuclide bone scan: In the early stage of necrosis, there is a perfusion defect (cold area); as the disease progresses, there is a cold area in the hot area, which is a "doughnut-like" change;

[0049] (6) Bone biopsy: showed that the empty pits of osteocytes in trabeculae accounted for more than 50% and involved multiple adjacent trabeculae, with bone marrow necrosis.

[0050] The diagnosis can be confirmed if two or more of the above six criteria are met. Except for (1) and (5), the diagnosis can be confirmed if one of (2, 3, 4, 6) is met.

[0051] 3 The staging criteria are based on the 2019 Association Research Circulation Osseuse (ARCO) osteonecrosis staging criteria, as shown in Table 1.

[0052] Table 1 ARCO staging of femoral head necrosis

[0053]

[0054] The TCM syndrome differentiation is that people with liver and kidney yin deficiency are usually thin and long, with hot hands and soles of feet, reddish complexion, dry eyes, slightly dry nose, dry mouth and throat. They like cold drinks, often have dry stools, can tolerate winter but not summer. They are also irritable, prone to insomnia, have red tongue with little fluid and coating, and have a weak and rapid pulse.

[0055] 4 Inclusion criteria

[0056] (1) Meet the diagnostic criteria for femoral head necrosis;

[0057] (2) those receiving conservative treatment;

[0058] (3) The primary disease is cured or in a stable stage;

[0059] (4) Those who are not accompanied by bone metabolic diseases, ankylosing spondylitis, bone tumors, various arthritis and other bone diseases;

[0060] (5) Be at least 18 years old and have the capacity to act independently;

[0061] (6) Patients who voluntarily participate in clinical research and sign the informed consent form.

[0062] 5 Exclusion criteria

[0063] (1) The primary disease has not been effectively controlled or is in the active stage;

[0064] (2) Patients with femoral head necrosis who refuse conservative treatment;

[0065] (3) Patients with other internal and external diseases other than the primary disease who require long-term medication;

[0066] (4) Pregnant or lactating women;

[0067] (5) Those who are currently participating in clinical trials of other drugs;

[0068] (6) Those who dropped out of the study or were lost to follow-up due to various reasons.

[0069] 6 Research Groups

[0070] The patients were numbered from 1 to 60 according to the order of their visits, and random numbers were generated using SPSS27.0. The patients were randomly divided into a treatment group and a control group according to the principle of random grouping, with 30 cases in each group.

[0071] 7. Medication

[0072] Treatment duration: 12 weeks

[0073] Control group: Xianling Gubao.

[0074] Treatment group: Xianling Gubao (specific usage is the same as the control group) combined with the Chinese medicine composition prepared in Example 2 of the present invention, 200 ml each time, once in the morning and once in the evening.

[0075] 8. Efficacy evaluation criteria

[0076] Harris score of hip joint function and visual analogue scale (VAS pain score) were observed in the two groups before treatment and 12 weeks after treatment, and the differences between the two groups before and after treatment were compared and analyzed.

[0077] 9 Clinical efficacy evaluation

[0078] After treatment, the P values ​​of Harris score and VAS pain score were less than 0.05, and the difference between the two groups was statistically significant. The therapeutic effect of the treatment group was better than that of the control group. The clinical efficacy evaluation is shown in Table 2.

[0079] Table 2 Comparison of Harris score and VAS pain score

[0080]

[0081] 10 In vitro cell experiments

[0082] Twelve 4-week-old SD rats were randomly divided into two groups, a control group and an experimental group. The control group was given Xianlinggubao solution by gavage, and the experimental group was given a mixture of Xianlinggubao and Chinese medicine combination by gavage once a day for a total of 14 days. Two hours after the last gavage intervention, the abdominal aorta blood of the rats was collected, centrifuged, inactivated, sterilized, and packaged, and the serum was stored at -20℃ for later use.

[0083] Four SD rats were anesthetized with 20% urethane and then killed. The femoral and tibia bone marrow of the rats were removed for BMSCs culture. The cells were passaged when the confluence reached 80% to 90%, and the cell morphology and growth were observed under an inverted microscope. The third-generation rat BMSCs were made into a single cell suspension, and the cells were inoculated into a 96-well plate. After the cells adhered to the wall, they were divided into a control group and an experimental group. The control group was cultured with complete culture medium containing 10% Xianling Gubao rat medicated serum, and the experimental group was cultured with complete culture medium containing 10% Xianling Gubao and a Chinese medicine combination of rat medicated serum. After 24h, 48h, 72h, and 96h, 10μL of CCK-8 solution was added to each well, and the cells were cultured in an incubator for 40min. The absorbance value was measured at a wavelength of 450nm using an enzyme-linked immunosorbent assay to understand the cell proliferation and the results. The results showed that the differences in the proliferation activity of BMSCs in rats in each group at different time points were statistically significant, that is, there was a time effect; the proliferation activity of BMSCs in rats in each group showed an upward trend over time; the overall comparison of the proliferation activity of BMSCs in rats in the two groups was statistically significant, that is, there was a grouping effect; there was an interaction effect between the time factor and the grouping factor; immediately after the intervention, there was no statistically significant difference in the proliferation activity of BMSCs in rats in each group; after 24h, 48h, 72h, and 96h of intervention, the overall comparison of the proliferation activity of BMSCs in rats in the five groups was statistically significant. The CCK8 results showed that the Chinese medicine combination had a significant promoting effect on the proliferation of BMSCs, as shown in Table 3.

[0084] Table 3 Statistics of proliferation activity of BMSCs in each group of rats

[0085]

[0086] 11. Safety Assessment

[0087] No adverse reactions occurred in the 60 patients during the treatment period, and no obvious abnormalities were found in vital signs, blood routine, urine routine, stool routine, electrocardiogram, liver and kidney function, and coagulation function after taking the medicine, indicating that the Chinese medicine of the present invention has good safety.

[0088] After repeated tests and practices, other embodiments all obtained the same or similar test results as Embodiment 2, which will not be described in detail one by one.

[0089] 12 Conclusion

[0090] From the above, it can be seen that the prescription of the present invention is rich in raw materials, simple in preparation method, easy to take, low in cost, good in effect, and the components support each other. It has the effects of nourishing yin and tonifying the kidney, replenishing essence and marrow, and strengthening the spleen and tonifying deficiency. The whole prescription not only has stable efficacy, but also good long-term efficacy, is not easy to relapse, and is easily accepted by patients. It is effectively used to treat femoral head necrosis of liver and kidney yin deficiency type. The Chinese medicine composition of the present invention, which is characterized by simplicity, convenience, low cost and effectiveness, not only conforms to the pathogenesis of femoral head necrosis, but also conforms to the theory of traditional Chinese medicine of tonifying liver blood and nourishing kidney yin. It is an innovation in drugs for treating femoral head necrosis, and has huge economic and social benefits.

[0091] It should be pointed out that the above is only a preferred embodiment of the present invention and does not limit the present invention in any form. Any technician familiar with the profession can make changes or modify the technical contents disclosed above into equivalent embodiments with equivalent changes without departing from the scope of the technical solution of the present invention, which all fall within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating liver-kidney yin deficiency type femoral head necrosis, characterized in that: The Chinese medicine soup is prepared from the following raw materials by weight: 15-25g of yam, 10-20g of cornus fruit, 8-16g of rehmannia root, 6-12g of dodder seed, 6-14g of tortoise shell with vinegar, 6-14g of turtle shell with vinegar, 10-20g of cyathula, 8-16g of privet fruit, 8-16g of wolfberry fruit, 6-14g of psoralea corylifolia, 6-12g of polygonum multiflorum, 6-14g of ligusticum chuanxiong, 6-12g of vinegar cyperus rotundus, 8-16g of white peony root, 6-14g of vinegar curcuma, 6-14g of vinegar trillium and 4-8g of liquorice.

2. The Chinese medicine composition for treating liver-kidney yin deficiency type femoral head necrosis according to claim 1, characterized in that: The Chinese medicine soup is prepared from the following raw materials by weight: 15g of yam, 10g of cornus fruit, 8g of rehmannia root, 6g of dodder seed, 6g of vinegar tortoise shell, 6g of vinegar turtle shell, 10g of cyathula, 8g of glossy privet fruit, 8g of wolfberry fruit, 6g of psoralea corylifolia, 6g of polygonum multiflorum, 6g of ligusticum chuanxiong, 6g of vinegar cyperus rotundus, 8g of white peony root, 6g of vinegar curcuma, 6g of vinegar trillium and 4g of liquorice.

3. The Chinese medicine composition for treating liver-kidney yin deficiency type femoral head necrosis according to claim 1, characterized in that: The Chinese medicine soup is prepared from the following raw materials by weight: 20g of yam, 15g of cornus fruit, 12g of rehmannia root, 9g of dodder seed, 10g of vinegar tortoise shell, 10g of vinegar turtle shell, 15g of cyathula, 12g of glossy privet fruit, 12g of wolfberry fruit, 10g of psoralea corylifolia, 9g of polygonum multiflorum, 10g of ligusticum chuanxiong, 9g of vinegar cyperus rotundus, 12g of white peony root, 9g of vinegar curcuma, 9g of vinegar trillium and 6g of liquorice.

4. The Chinese medicine composition for treating liver-kidney yin deficiency type femoral head necrosis according to claim 1, characterized in that: The Chinese medicine soup is prepared from the following raw materials by weight: 25g of yam, 20g of cornus fruit, 16g of rehmannia root, 12g of dodder seed, 14g of vinegar tortoise shell, 14g of vinegar turtle shell, 20g of cyathula, 16g of glossy privet fruit, 16g of wolfberry fruit, 14g of psoralea corylifolia, 12g of polygonum multiflorum, 14g of ligusticum chuanxiong, 12g of vinegar cyperus rotundus, 16g of white peony root, 14g of vinegar curcuma, 14g of vinegar trillium and 8g of liquorice.

5. The method for preparing the Chinese medicine composition for treating liver-kidney yin deficiency type femoral head necrosis according to any one of claims 1 to 4, characterized in that: It can be prepared into decoction, pills, tablets, granules and ointments with pharmaceutically acceptable excipients.

6. The method for preparing the Chinese medicine composition for treating liver-kidney yin deficiency type femoral head necrosis according to claim 5, characterized in that: Add 400-600ml of water to all the raw materials, soak for 15-25min at 18-25℃, then bring to a boil over high heat, then turn to low heat, boil for 20-30min, filter, and obtain the filtrate for later use; add 300-400ml of water to the residue, bring to a boil over high heat, then turn to low heat, boil for 10-15min, filter, discard the residue, and obtain the filtrate, combine the two filtrates, and concentrate to 1 / 2-1 / 3 of the amount of water added twice.

7. Use of the Chinese medicine composition for treating liver-kidney yin deficiency type femoral head necrosis according to any one of claims 1 to 4 in the preparation of drugs for liver-kidney yin deficiency type femoral head necrosis.

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