Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating epilepsy

Abstract

The traditional Chinese medicine composition is prepared from the following components in parts by mass: 27 to 33 parts of cassia occidentalis, 17 to 23 parts of rhizoma acori graminei, 13 to 17 parts of ramulus uncariae cum uncis, 8 to 12 parts of radix curcumae, 8 to 12 parts of rhizoma coptidis, 8 to 12 parts of flos chrysanthemi indici, 8 to 12 parts of poria with hostwood, 8 to 12 parts of flos albiziae, 5 to 7 parts of sea cucumber intestines and 2.5 to 3.5 parts of cortex cinnamomi. The traditional Chinese medicine composition can be prepared into traditional Chinese medicine watered pills; according to the invention, a treatment principle is determined aiming at main pathogenesis, the problem that the curative effect on different types of epilepsy is difficult to guarantee is avoided, and the effective proportion and the total effective rate of the treatment effect are improved.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition and a traditional Chinese medicine preparation for treating epilepsy. Background Art

[0002] Epilepsy is a disease characterized by recurrent episodes of abnormal consciousness, clinically characterized by sudden loss of consciousness, collapse, unconsciousness, tonic convulsions, drooling, looking up or making strange noises, waking up after a while, and acting like a normal person. Western medicine methods for treating epilepsy are all aimed at controlling the onset of the disease from the perspective of forcibly inhibiting abnormal nerve discharges. However, most anti-epileptic Western medicines have great toxic side effects and poor compliance. Long-term use often causes patients to experience side effects such as thickened gums, hirsutism, rough skin, slow reaction, poor spirit, damaged liver function, and decreased white blood cells. More importantly, it can affect the patient's intelligence, cause irreversible brain damage, and even cause delayed side effects such as teratogenicity and carcinogenicity.

[0003] In the field of traditional Chinese medicine, epilepsy is considered to be an "epileptic disease". In the Suwen Zhizhen Yao Da Lun, there is a record that "all wind-induced dizziness and vertigo belong to the liver". Generally speaking, the causes of epilepsy are believed to include the following: liver wind moves internally, phlegm moves with the wind, wind and phlegm disturb the mind and blind the heart; liver wind is strong, fire moves to generate wind, fire evil refines liquid into phlegm, wind moves phlegm and blocks the heart; temperament is phlegm-turbid, excessive consumption of alcohol, fat and sweet foods damages the spleen and stomach and causes dampness to gather and generate phlegm, and blood stasis blocks the brain. Therefore, it is often believed that epilepsy is always rooted in "phlegm blocking the mind", and treatment is mainly based on "clearing phlegm and concentrating the mind", "calming the liver and extinguishing wind", and supplemented by "reducing dryness and resolving phlegm".

[0004] However, epilepsy can be further subdivided into psychomotor epilepsy, headache epilepsy, abdominal pain epilepsy, vegetative epilepsy, etc. Existing treatment ideas may not take into account the causes of multiple types of epilepsy, so it is necessary to study treatment ideas and Chinese medicine compositions suitable for different types of epilepsy. Summary of the invention

[0005] The purpose of the present invention is to provide a treatment idea and a Chinese medicine composition suitable for different types of epilepsy, determine the treatment principle according to the main cause, and avoid the problem that the efficacy of different types of epilepsy is difficult to guarantee.

[0006] The technical solution adopted by the present invention provides a traditional Chinese medicine composition for treating epilepsy. The key lies in that, measured by weight, the traditional Chinese medicine composition is made of 27 to 33 parts of Cassia tora, 17 to 23 parts of Acorus calamus, 13 to 17 parts of Uncaria rhynchophylla, 8 to 12 parts of Curcuma aromatica, 8 to 12 parts of Coptis chinensis, 8 to 12 parts of Chrysanthemum indici, 8 to 12 parts of Poria, 8 to 12 parts of Albizzia julibrissin, 5 to 7 parts of Sea Cucumber Intestine and 2.5 to 3.5 parts of Cinnamon Bark.

[0007] Preferably, the above-mentioned traditional Chinese medicine composition is made of 30 parts of Cassia tora, 20 parts of Acorus calamus, 15 parts of Uncaria rhynchophylla, 10 parts of Curcuma aromatica, 10 parts of Coptis chinensis, 10 parts of Chrysanthemum indici, 10 parts of Poria, 10 parts of Albizzia julibrissin, 6 parts of Sea Cucumber Intestine and 3 parts of Cinnamon bark, by weight.

[0008] Furthermore, the above-mentioned traditional Chinese medicine composition is soaked in cold water for 30min to 50min, simmered for 20min to 30min from the beginning of boiling, and second simmered for 15min to 25min, the residue is filtered out to obtain a decoction, and taken orally twice a day in the morning and evening.

[0009] The Chinese medicine preparation for treating epilepsy uses the above-mentioned Chinese medicine composition as a medicinal material. The key is that the above-mentioned Chinese medicine preparation is a water pill. The specific preparation steps include:

[0010] S1. Material selection and formulation: Select Chinese herbal medicines that comply with the provisions of the Chinese Pharmacopoeia, wash and dry them, crush them into fine powder, and mix them according to the formula ratio;

[0011] S2. Adjust moisture: add water, wine or honey, and stir until it sticks together;

[0012] S3. Pilling: Make pills using a pilling machine or a manual pilling machine, and package the finished products.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] The present invention uses Cassiae as the main ingredient, which is Cassiae seed, and has the functions of clearing the liver and improving eyesight, and relieving constipation. It is mainly used to treat hypertension, headache, dizziness, acute conjunctivitis, corneal ulcer, glaucoma, carbuncle, furuncle, sore and the like. In the Chinese medicine composition for treating epilepsy, it is often used as an auxiliary medicine, but the effect of Cassiae on calming liver wind cannot be exerted. The present invention uses Cassiae as the main ingredient, fully utilizing the effects of Cassiae on calming liver wind, calming liver fire and assisting liver qi, and is directly against the main cause of epilepsy.

[0015] Acorus calamus and Uncaria rhynchophylla are the assistants. Acorus calamus is a medicine for opening the orifices, which has the effects of opening the orifices and clearing phlegm, refreshing the mind and improving intelligence, removing dampness and stimulating appetite, and is just for the symptoms of "wind stirring phlegm and blocking the heart". Uncaria rhynchophylla is sweet, mild and mild, slightly cold and clear, with a clear and penetrating nature. It mainly enters the liver meridian and the pericardium meridian, and has the effects of calming wind and calming convulsions, clearing heat and calming the liver. It is mainly used to treat dizziness and vertigo caused by hyperactivity of yang, headache caused by liver heat, head swelling, convulsions, epilepsy and convulsions, and helps Cassia to calm the liver wind.

[0016] Curcuma is a good product for promoting blood circulation and removing blood stasis. It mainly promotes blood circulation, blood circulation, and is pungent, bitter, cold in nature, and enters the liver, heart, and lung meridians. Curcuma moves blood and qi, which not only promotes blood circulation and relieves pain, but also relieves liver qi and relieves depression, and has the wonderful effect of cooling blood, stopping bleeding, and refreshing the mind. It is better to be supplemented with pungent and warm medicines. Cinnamon is a warming medicine, which has the effects of replenishing fire and supporting yang, guiding fire back to the origin, dispersing cold and relieving pain, and warming and unblocking the meridians. A small amount of cinnamon and curcuma in the present invention complement each other, and are more suitable for the treatment of epilepsy than pungent and cool antipyretic drugs.

[0017] The present invention has bitter taste, cold nature, enters the Shaoyin Heart Channel, clears the heart and reduces fever, relieves fire and relieves restlessness, and has the effects of clearing heat and drying dampness, purging fire and detoxifying. However, it is recorded in "Zhenzhu Nang" that the coptis root also has the effect of removing dampness and heat in the middle jiao. The present invention can prevent dampness from accumulating and generating phlegm, and promote the ability of the middle jiao to transport and transform phlegm and dampness.

[0018] Wild chrysanthemum, spicy and dispersing, clearing the body to the surface, clearing the qi and floating upward, slightly cold and clearing away heat, has the effect of dispersing wind-heat in the lung meridian, but the power of dispersing the surface evil is not strong, and the cinnamon bark in the present invention can also make up for its effect.

[0019] In the concentration scheme for epilepsy, the present invention selects Poria and Albizzia julibrissin to complement each other. Poria is different from Poria cocos. Poria has the effects of diuresis, tranquilizing the mind, and calming the heart; while Poria cocos has the effects of calming the heart, diuresis, and invigorating the spleen. Albizzia julibrissin has the effect of relieving depression and tranquilizing the mind compared to Albizzia julibrissin bark, and has a good effect on relieving restlessness caused by emotional frustration, depression, insomnia, etc.

[0020] Sea cucumber intestines are used to treat epilepsy and are often used in drugs for treating epilepsy. The efficacy of sea cucumber intestines can be doubled in the treatment scheme of the present invention. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] Embodiment 1

[0023] A Chinese medicine composition for treating epilepsy is made from the following Chinese medicines: 33g of Cassia tora, 17g of Acorus calamus, 13g of Uncaria rhynchophylla, 12g of Curcuma aromatica, 8g of Coptis chinensis, 12g of Chrysanthemum indica, 8g of Poria, 12g of Albizzia julibrissin, 5g of Sea Cucumber Intestine and 3.5g of Cinnamon bark.

[0024] Soak the above Chinese medicinal materials in cold water for 40 minutes, and simmer over low heat for 25 minutes from the moment the water boils; simmer for 20 minutes for the second time, filter out the residue and take 300 mL of juice.

[0025] Take orally twice a day, morning and evening. One course of treatment is four weeks.

[0026] Embodiment 2

[0027] A Chinese medicine composition for treating epilepsy is composed of the following Chinese medicines: 27g of Cassia tora, 23g of Acorus calamus, 17g of Uncaria rhynchophylla, 8g of Curcuma aromatica, 12g of Coptis chinensis, 8g of Chrysanthemum indica, 12g of Poria, 8g of Albizzia julibrissin, 7g of Sea Cucumber Intestine and 2.5g of Cinnamon bark.

[0028] Soak the above Chinese medicinal materials in cold water for 50 minutes, and simmer them over low heat from the moment the water boils, i.e., 30 minutes for the first decoction and 15 minutes for the second decoction. Filter out the residue and take out 320 mL of juice in total.

[0029] Take orally twice a day, morning and evening. One course of treatment is four weeks.

[0030] Embodiment 3

[0031] A Chinese medicine composition for treating epilepsy is made from the following Chinese medicines: 30g of Cassia tora, 20g of Acorus calamus, 15g of Uncaria rhynchophylla, 10g of Curcuma aromatica, 10g of Coptis chinensis, 10g of Chrysanthemum indica, 10g of Poria, 10g of Albizzia julibrissin, 6g of Sea Cucumber Intestine and 3g of Cinnamon bark.

[0032] Soak the above Chinese medicinal materials in cold water for 30 minutes, and simmer for 20 minutes from the time the pot boils; simmer for 20 minutes for the first decoction and the second decoction, filter out the residue and take out 290 mL of juice.

[0033] Take orally twice a day, morning and evening. One course of treatment is four weeks.

[0034] Embodiment 4

[0035] Prepare the water pills for treating epilepsy as follows:

[0036] S1. Material selection and formulation: Select Chinese herbal medicines that comply with the provisions of the Chinese Pharmacopoeia, wash and dry them, crush them into fine powders below 60 mesh, and mix them according to the following formula;

[0037] The Chinese medicinal powder is composed of the following parts by mass: 33 parts of Cassia tora, 17 parts of Acorus calamus, 13 parts of Uncaria rhynchophylla, 12 parts of Curcuma aromatica, 8 parts of Coptis chinensis, 12 parts of Chrysanthemum indici, 8 parts of Poria, 12 parts of Albizzia julibrissin, 5 parts of Sea Cucumber Intestine and 3.5 parts of Cinnamon Bark.

[0038] S2. Adjust moisture: Add water and stir until it sticks together.

[0039] S3, pilling: the product is pilled by a pilling machine and packaged.

[0040] Embodiment 5

[0041] Prepare the water pills for treating epilepsy as follows:

[0042] S1. Material selection and formulation: Select Chinese herbal medicines that comply with the provisions of the Chinese Pharmacopoeia, wash and dry them, crush them into fine powders below 60 mesh, and mix them according to the following formula;

[0043] The Chinese medicinal powder is composed of the following parts by mass: 27 parts of Cassia tora, 23 parts of Acorus calamus, 17 parts of Uncaria rhynchophylla, 8 parts of Curcuma aromatica, 12 parts of Coptis chinensis, 8 parts of Chrysanthemum indici, 12 parts of Poria, 8 parts of Albizzia julibrissin, 7 parts of Sea Cucumber Intestine and 2.5 parts of Cinnamon bark.

[0044] S2. Adjust moisture: Add wine and stir until it sticks together.

[0045] S3, pelleting: pelleting is done by a pelleting machine and the finished product is packaged.

[0046] Embodiment 6

[0047] Prepare the water pills for treating epilepsy as follows:

[0048] S1. Material selection and formulation: Select Chinese herbal medicines that comply with the provisions of the Chinese Pharmacopoeia, wash and dry them, crush them into fine powders below 60 mesh, and mix them according to the following formula;

[0049] The Chinese medicinal powder is composed of the following parts by mass: 30 parts of Cassia tora, 20 parts of Acorus calamus, 15 parts of Uncaria rhynchophylla, 10 parts of Curcuma aromatica, 10 parts of Coptis chinensis, 10 parts of Chrysanthemum indici, 10 parts of Poria, 10 parts of Albizzia julibrissin, 6 parts of Sea Cucumber Intestine and 3 parts of Cinnamon bark.

[0050] S2. Adjust moisture: Add honey, stir until it sticks together and pack into pills.

[0051] The effects of the Chinese medicine composition for treating epilepsy provided by the present invention are described below.

[0052] 1. General Information

[0053] A total of 108 epilepsy patients were randomly divided into treatment group (n=68) and control group (n=40).

[0054] There were 38 males and 30 females in the treatment group, with an average age of 40.2 years and an average disease course of 12 years and 2 months; there were 23 males and 17 females in the control group, with an average age of 39.8 years and an average disease course of 11 years and 9 months.

[0055] The clinical data of the two groups of patients were statistically processed and showed no significant difference, so they were judged to be comparable.

[0056] Explanation on the dropout situation in the two groups: Both the treatment group and the control group completed the clinical trial, and there was no record of dropout.

[0057] 2. Diagnosis and exclusion criteria

[0058] 2.1 Diagnostic criteria

[0059] According to the "Guidelines for Clinical Research on New Chinese Medicines for the Treatment of Epilepsy", the main symptoms of epilepsy include strong convulsions in the limbs, accompanied by high breathing and rough breathing, mania and restlessness, red tongue with yellow greasy coating, and slippery and rapid pulse; secondary symptoms include constipation, dark urine, bitter and dry mouth, irritability at ordinary times or before an attack, and headaches and insomnia.

[0060] 2.2 Efficacy evaluation and judgment criteria

[0061] Different scores were assigned to symptoms of vigorous convulsions of the limbs, high breathing, mania, irritability during normal times or before an attack, headache and insomnia, etc. The changes in scores before and after treatment were statistically calculated according to the nimodipine method. The calculation formula is:

[0062] Symptom score reduction ratio = (score before treatment - score after treatment) ÷ score before treatment × 100%.

[0063] In addition, the duration of onset and the frequency of onset are also listed as judgment criteria in the present invention.

[0064] 2.2.1 Criteria for determining efficacy

[0065] (1) Clinical cure: symptoms and signs disappear or almost disappear, and the symptom score decreases by ≥95%; epilepsy no longer occurs during the statistical period.

[0066] (2) Significant effect: symptoms and signs are significantly improved, with symptom scores reduced by ≥70%; the frequency of epilepsy attacks is reduced by more than 75%; and the duration of the attacks is reduced by more than 80%.

[0067] (3) Effective: Symptoms and signs improved, with symptom scores reduced by ≥30%; the frequency of epilepsy attacks reduced by more than 25% and less than 75%; and the duration of the attacks reduced by more than 40% and less than 80%.

[0068] (4) Ineffective: There is no significant improvement in symptoms and signs or they may even worsen; the symptom score is reduced by less than 30%; the frequency of epilepsy attacks is reduced by less than 25%; and the duration of the attacks is reduced by less than 40%.

[0069] 2.2.2 Statistical methods

[0070] The medical statistics software SPSS 22.0 was used for statistical analysis, and the measurement data and count data were analyzed using t-test and X-test, respectively. 2 Test, P < 0.05 indicates a significant difference, which is statistically significant.

[0071] 3. Treatment methods

[0072] The treatment group was administered the Chinese medicine composition described in Example 3 of the present invention, twice a day, half an hour before breakfast and dinner.

[0073] The control group was given phenytoin sodium tablets, 300 mg per day, divided into two doses.

[0074] A course of treatment was four weeks for both the treatment group and the control group. The most recent symptom was scored after 12 courses of treatment. The duration and frequency of the disease within one year were calculated for cases after three courses of treatment. The specific statistical and analysis results are shown in Table 1.

[0075] Among them, the total effective rate = (number of clinically cured cases + number of markedly effective cases + number of effective cases) ÷ number of cases × 100%.

[0076] Using t-test and X 2 The test results showed that *P<0.05, indicating that the statistical results in Table 1 are significant.

[0077] Table 1: Comparison of efficacy after treatment

[0078]

[0079] As shown in Table 1, after 3 courses of treatment, continuous follow-up and treatment for 1 year, there was 1 case without recurrence in the treatment group, and the significant effect rate reached 52.94%, and the total effective rate reached 86.76%, both higher than the control group. There were a certain number of ineffective cases in both the treatment group and the control group, which were mainly patients with a course of disease of more than 18 years, and there was no significant gender distinction. Therefore, in view of this characteristic of epilepsy, the treatment cycle can be extended according to the patient's own characteristics such as course of disease and age.

[0080] At the same time, no adverse reactions such as gastrointestinal discomfort, vomiting and nausea were found in the treatment group; while 12 patients in the control group experienced nausea, vomiting and other problems to varying degrees.

Claims

1. A Chinese medicine composition for treating epilepsy, characterized in that: The traditional Chinese medicine composition is made of 27 to 33 parts of Cassia tora, 17 to 23 parts of Acorus calamus, 13 to 17 parts of Uncaria rhynchophylla, 8 to 12 parts of Curcuma aromatica, 8 to 12 parts of Coptis chinensis, 8 to 12 parts of Chrysanthemum indici, 8 to 12 parts of Poria, 8 to 12 parts of Albizzia julibrissin, 5 to 7 parts of Sea Cucumber Intestine and 2.5 to 3.5 parts of Cinnamon Bark by weight.

2. The Chinese medicine composition for treating epilepsy according to claim 1, characterized in that: The Chinese medicine composition is prepared by weight from 30 parts of Cassia tora, 20 parts of Acorus calamus, 15 parts of Uncaria rhynchophylla, 10 parts of Curcuma aromatica, 10 parts of Coptis chinensis, 10 parts of Chrysanthemum indici, 10 parts of Poria, 10 parts of Albizzia julibrissin, 6 parts of Sea Cucumber Intestine and 3 parts of Cinnamon bark.

3. The Chinese medicine composition for treating epilepsy according to claim 1, characterized in that: Soak the Chinese medicine composition in cold water for 30 to 50 minutes, simmer for 20 to 30 minutes on a low fire from the time the pot boils, simmer for 15 to 25 minutes, filter out the residue to obtain a decoction, and take it orally twice a day, morning and evening.

4. A Chinese medicine preparation for treating epilepsy, wherein the Chinese medicine composition according to any one of claims 1 to 3 is used as a Chinese medicine, characterized in that: The Chinese medicine preparation is a water pill, and the specific preparation steps include: S1. Material selection and formulation: Select Chinese herbal medicines that comply with the provisions of the Chinese Pharmacopoeia, wash and dry them, crush them into fine powder, and mix them according to the formula ratio; S2. Adjust moisture: add water, wine or honey, and stir until it sticks together; S3. Pilling: Make pills using a pilling machine or a manual pilling machine, and package the finished products.

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