Traditional Chinese medicine composition with effect of dredging collaterals of muscles and bones, traditional Chinese medicine ointment for preparing plaster for dredging collaterals of muscles and bones and preparation method of traditional Chinese medicine ointment

Abstract

The invention provides a traditional Chinese medicine composition with a function of dredging collaterals of muscles and bones, a traditional Chinese medicine ointment which comprises the traditional Chinese medicine composition and is used for preparing a plaster for dredging collaterals of muscles and bones and a preparation method of the traditional Chinese medicine ointment. According to the traditional Chinese medicine composition with the effect of dredging collaterals of muscles and bones, several Chinese herbal medicines are combined with a biological enzyme hydrolysis degradation technology; effective active ingredients, which cannot be directly utilized after entering a human body, in Chinese herbal medicines are hydrolyzed and degraded into small-molecule active substances such as oligosaccharide and oligopeptide which are easily dissolved in solvents such as water, alcohol or glycerol through biological enzyme, so that the small-molecule active ingredients in biological enzyme hydrolysate have a relatively strong transdermal permeation effect; according to the traditional Chinese medicine composition, pharmacodynamic molecules can be fully dissolved and easily absorbed by a human body, the pharmacodynamic effect is remarkably improved, meanwhile, the dissolving capacity of the traditional Chinese medicine composition in auxiliary materials can be enhanced, the pharmacodynamic effects of the Chinese herbal medicines are greatly improved, and meanwhile the effective treatment application dosage of the Chinese herbal medicines can be greatly reduced.

Description

Technical Field

[0001] The invention belongs to the technical field of health care, and particularly relates to a traditional Chinese medicine composition with the function of promoting the flow of tendons and bones, a traditional Chinese medicine ointment for preparing a tendon and bone dredging patch comprising the traditional Chinese medicine composition, and a preparation method thereof. Background Art

[0002] Osteoarthritis (OA), also known as degenerative arthritis and proliferative arthritis, is a common chronic joint disease characterized by damage to articular cartilage. It is a group of heterogeneous diseases that cause joint symptoms and signs due to the destruction of articular cartilage integrity and lesions of the subchondral bone plate at the edge of the joint. Clinically, it is a multiple and relatively difficult to treat chronic progressive osteoarthritis.

[0003] There is no clear name for osteoarthritis in traditional Chinese medicine. The symptoms of this type of disease are mostly described in the category of "bi" or "wei". For example, "The Yellow Emperor's Classic of Internal Medicine" says: "The disease is in the bones, the bones are heavy and cannot be lifted, the bone marrow is sore and painful, and the cold air arrives. It is called bone bi"; "Golden Gui Yao Lue" records that the pathology of "stroke and joint disease" is "tendon injury" and "bone atrophy", and the clinical manifestations are "joint pain, inability to flex and stretch", and combines prescriptions such as Guizhi Fuzi Decoction and Guizhi Shaoyao Zhimu Decoction. Traditional Chinese medicine plays an important role in the treatment of osteoarthritis.

[0004] Zhou Qihui ("Summary of 120 cases of primary osteoarthritis treated with Tongbi Pain Relief Paste", Hunan Journal of Traditional Chinese Medicine, Vol. 18, No. 1, January 2002) disclosed a Tongbi Pain Relief Paste for external application, the drug composition of which is: 30g of Angelicae Sinensis, 30g of Angelicae Dahuricae, 15g of Raw Chuanwu, 15g of Raw Caowu, 30g of Natural Copper, 15g of Cinnamon Twig, 30g of Herba Scutellariae, 15g of Oleander, 15g of Myrrh, the above drugs are ground into powder, and honey is used to make an ointment for standby use. When using, the Tongbi Pain Relief Paste is applied to the affected area, covered with a dressing, fixed with adhesive tape, and the dressing is changed once every other day. Three times constitute one course of treatment, and two courses of treatment are used in succession. In the prescription, Raw Chuanwu, Raw Caowu, and Cinnamon Twig warm the meridians, dispel cold, and relieve pain; Angelicae Sinensis, Natural Copper, Oleander, Myrrh, and Herba Scutellariae promote blood circulation and remove blood stasis, dredge the meridians, and relieve pain; and Angelicae Dahuricae dispels wind, overcomes dampness, and relieves pain. The combination of these medicines can achieve the purpose of removing cold and dampness, activating qi and blood, unblocking meridians, unblocking tendons and veins, and eliminating arthralgia and pain.

[0005] However, the above-mentioned Tongbi analgesic ointment for treating primary osteoarthritis has deficiencies such as incomplete extraction of active ingredients and low bioavailability. Although some therapeutic effects have been achieved, the cure rate is still not ideal, especially the long-term rebound rate is high.

[0006] Therefore, it is very necessary to develop a Chinese medicine ointment that can treat bone diseases more effectively, has no long-term rebound, and has no toxic side effects. Summary of the invention

[0007] In view of the defects of the prior art, the purpose of the present invention is to provide a traditional Chinese medicine composition with the effect of dredging tendons and bones, a traditional Chinese medicine plaster for preparing a tendon and bone dredging patch comprising the traditional Chinese medicine composition, and a preparation method thereof.

[0008] To achieve the above purpose, the solution adopted by the present invention is as follows:

[0009] In a first aspect, the present invention provides a Chinese medicine composition having the function of promoting the flow of tendons and bones, comprising the following raw materials in parts by weight: 10-30 parts by weight of dried ginger, 10-20 parts by weight of safflower, 5-15 parts by weight of cinnamon bark, 5-15 parts by weight of chuanxiong, 5-15 parts by weight of eucommia bark, 5-10 parts by weight of angelica sinensis, 5-10 parts by weight of frankincense, 5-10 parts by weight of myrrh, 5-10 parts by weight of chuanxiong, 5-10 parts by weight of angelica dahurica, 5-10 parts by weight of rhubarb, 5-15 parts by weight of drynariae rhizome, -15 weight parts, 5-15 weight parts of Acorus calamus, 5-10 weight parts of Notopterygium wilfordii, 5-10 weight parts of processed Aconitum kusnezoffii, 5-10 weight parts of processed Chuanwuji, 5-10 weight parts of Datura stramonium, 5-10 weight parts of Clematis, 5-10 weight parts of peach kernel, 5-10 weight parts of Eupatorium fortunei, 3-8 weight parts of Larkspur odoratum, 3-8 weight parts of Lycopodiella cuneata, 3-8 weight parts of Phellodendron chinense, 3-8 weight parts of Panax notoginseng, 3-8 weight parts of Sappan wood, 3-8 weight parts of Cistanche deserticola, and 3-8 weight parts of Astronomy grass.

[0010] Preferably, the traditional Chinese medicine composition comprises one or more of the powder of each raw material drug, the water or organic solvent extract of each raw material drug and the bio-enzyme hydrolyzate of each raw material drug.

[0011] Preferably, the biological enzyme used in the biological enzyme hydrolysis product of the raw material drug is one or more selected from protease, cellulase, amylase, lipase and lysozyme, preferably cellulase.

[0012] Preferably, it includes:

[0013] (1) Enzyme hydrolyzates of the following Chinese medicinal ingredients in parts by weight: 10-30 parts by weight of dried ginger, 10-20 parts by weight of safflower, 5-15 parts by weight of cinnamon bark, 5-15 parts by weight of chuanxiong, 5-15 parts by weight of eucommia bark, 5-10 parts by weight of angelica sinensis, 5-10 parts by weight of frankincense, 5-10 parts by weight of myrrh, 5-10 parts by weight of dipsaccharum officinale, and 5-10 parts by weight of angelica dahurica; and

[0014] (2) The following parts by weight are the water or organic solvent extracts of each Chinese medicinal ingredient: 5-15 parts by weight of rhubarb, 5-15 parts by weight of drynaria, 5-15 parts by weight of calamus, 5-10 parts by weight of notopterygium, 5-10 parts by weight of processed aconite, 5-10 parts by weight of processed chuanwu, 5-10 parts by weight of datura, 5-10 parts by weight of clematis, 5-10 parts by weight of peach kernel, 5-10 parts by weight of zedoaria, 3-8 parts by weight of larkspur, 3-8 parts by weight of lycopodii, 3-8 parts by weight of phellodendron, 3-8 parts by weight of notoginseng, 3-8 parts by weight of sappan wood, 3-8 parts by weight of cinnamomum villosum, and 3-8 parts by weight of aster.

[0015] In a second aspect, the present invention further provides a traditional Chinese medicine ointment for preparing a tendon-bone-draining patch, comprising the traditional Chinese medicine composition having tendon-bone-draining patch effect as described above.

[0016] Preferably, it also includes pharmaceutically acceptable excipients, which include at least one of an inert diluent, a dispersant and / or a granulating agent, a surfactant and / or an emulsifier, a disintegrant, a binder, a preservative, a buffer, a lubricant and / or a lubricating oil.

[0017] Preferably, the auxiliary materials include borneol, vaseline, glycerin and paraffin.

[0018] In a third aspect, the present invention further provides a method for preparing the traditional Chinese medicine plaster for preparing the Jingu Tongluo patch as described above, comprising the following steps:

[0019] Step (1), weighing dried ginger, safflower, cinnamon bark, chuanxiong, eucommia bark, angelica sinensis, frankincense, myrrh, chuanxiong and angelica dahurica according to the proportion, crushing, passing through a 40-mesh sieve, soaking in 5-10 times of water, adding cellulase, heating and boiling, collecting volatile oil by steam distillation, filtering the decoction, concentrating and drying the filtrate to obtain an extract powder 1;

[0020] Step (2), according to the proportion, weigh rhubarb, drynaria, calamus, notopterygium, processed aconite, processed Chuanwu, datura, clematis, peach kernel, zedoaria, larkspur, lycopodii, phellodendron, phellodendron, notoginseng, sappan wood, cinnamomea glutinosa and astronomical herb, crush, pass through a 40-mesh sieve, add 10-15 times of 50-80% ethanol, ultrasonically extract, filter, add 10-15 times of 50-80% ethanol to the residue, ultrasonically extract, filter, combine the two extracts, concentrate and dry the filtrate to obtain extract powder 2;

[0021] Step (3), heating borneol, vaseline, glycerin and paraffin in a water bath, adding the volatile oil, extract powder 1 and extract powder 2 obtained above after melting, grinding evenly, and pressing into shape with a mold to obtain the Chinese medicine ointment for preparing the Jingu Tongluo patch.

[0022] Preferably, the amount of the cellulase is 0.5-5%, preferably 0.5-2.5% of the amount of the medicinal material.

[0023] Preferably, in step (1), the temperature of heating and decocting after adding cellulase is 20-80°C and the time is 3-144 hours.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] The Chinese medicine composition with the function of promoting tendons and dredge meridians prepared by the present invention combines several Chinese herbal medicines with bioenzyme hydrolysis and degradation technology, and degrades the effective active ingredients in the Chinese herbal medicines that cannot be directly utilized after entering the human body into small molecular active substances such as oligosaccharides and low peptides that are easily soluble in water, alcohol or glycerol and other solvents through bioenzyme hydrolysis, so that the small molecular active ingredients in the bioenzyme hydrolysis products have a strong transdermal permeation effect, can make the drug molecules fully dissolved and easy to be absorbed by the human body, and significantly improve the drug efficacy. At the same time, the solubility of the Chinese medicine composition in the auxiliary materials can also be enhanced, and while greatly improving the drug efficacy of these several Chinese herbal medicines, the effective therapeutic application dosage of the Chinese herbal medicines can also be greatly reduced. DETAILED DESCRIPTION

[0026] The invention provides a traditional Chinese medicine composition with the function of strengthening tendons and dredge meridians, comprising the following raw materials in parts by weight: 10-30 parts by weight of dried ginger, 10-20 parts by weight of safflower, 5-15 parts by weight of cinnamon bark, 5-15 parts by weight of chuanxiong rhizome, 5-15 parts by weight of eucommia bark, 5-10 parts by weight of angelica sinensis, 5-10 parts by weight of frankincense, 5-10 parts by weight of myrrh, 5-10 parts by weight of chuanxiong root, 5-10 parts by weight of angelica root, 5-10 parts by weight of angelica root, 5-15 parts by weight of rhubarb, 5-15 parts by weight of drynaria root, by weight, 5-15 parts by weight of Acorus calamus, 5-10 parts by weight of Notopterygium wilfordii, 5-10 parts by weight of processed Aconitum kusnezoffii, 5-10 parts by weight of processed Chuanwuji, 5-10 parts by weight of Datura stramonium, 5-10 parts by weight of Clematis, 5-10 parts by weight of Peach Kernel, 5-10 parts by weight of Eupatorium fortunei, 3-8 parts by weight of Larix gracile, 3-8 parts by weight of Lycopodiella cuneata, 3-8 parts by weight of Phellodendron chinense, 3-8 parts by weight of Panax notoginseng, 3-8 parts by weight of Sappanwood, 3-8 parts by weight of Caulis cinnamomi, and 3-8 parts by weight of Herba Astragali.

[0027] In a Chinese medicine composition with the effect of promoting the flow of tendons and bones provided by the present invention, the Chinese medicine composition includes the powder of each raw material medicine, the water or organic solvent extract of each raw material medicine, or the biological enzyme hydrolysis product of each raw material medicine. Among them, the biological enzyme used in the biological enzyme hydrolysis product of the raw material medicine includes but is not limited to protease, cellulase, amylase, lipase or lysozyme. In the embodiment of the present invention, cellulase is taken as an example to illustrate the technical solution of the present invention.

[0028] The present invention also provides a traditional Chinese medicine plaster for preparing a tendon-bone-dredge-channel plaster, comprising the traditional Chinese medicine composition having tendon-bone-dredge-channel effect as described above as an active ingredient.

[0029] The Chinese medicine ointment for preparing the Jingu Tongluo patch provided by the present invention also includes pharmaceutically acceptable excipients, including at least one of an inert diluent, a dispersant and / or a granulating agent, a surfactant and / or an emulsifier, a disintegrant, a binder, a preservative, a buffer, a lubricant and / or a lubricating oil, for example, borneol, vaseline, glycerin and paraffin.

[0030] The present invention further provides a method for preparing the above-mentioned traditional Chinese medicine plaster for preparing the Jingu Tongluo patch, comprising the following steps:

[0031] Step (1), weighing dried ginger, safflower, cinnamon bark, chuanxiong, eucommia bark, angelica sinensis, frankincense, myrrh, chuanxiong and angelica dahurica according to the proportion, crushing, passing through a 40-mesh sieve, soaking in 5-10 times of water, adding cellulase, heating and boiling, collecting volatile oil by steam distillation, filtering the decoction, concentrating and drying the filtrate to obtain an extract powder 1;

[0032] Step (2), according to the proportion, weigh rhubarb, drynaria, calamus, notopterygium, processed aconite, processed Chuanwu, datura, clematis, peach kernel, zedoaria, larkspur, lycopodii, phellodendron, phellodendron, notoginseng, sappan wood, cinnamomea glutinosa and astronomical herb, crush, pass through a 40-mesh sieve, add 10-15 times of 50-80% ethanol, ultrasonically extract, filter, add 10-15 times of 50-80% ethanol to the residue, ultrasonically extract, filter, combine the two extracts, concentrate and dry the filtrate to obtain extract powder 2;

[0033] Step (3), heating borneol, vaseline, glycerin and paraffin in a water bath, adding the volatile oil, extract powder 1 and extract powder 2 obtained above after melting, grinding evenly, and pressing into shape with a mold to obtain the Chinese medicine ointment for preparing the Jingu Tongluo patch.

[0034] The present invention adopts biological enzymes such as cellulase to perform biological enzyme hydrolysis and degradation treatment on dried ginger, safflower, cinnamon, chuanxiong, eucommia, angelica, frankincense, myrrh, chuanxiong and angelica dahurica in the traditional Chinese medicine composition with tendon and bone dredging effect of the present invention, so as to carry out biotransformation of the chemical components of traditional Chinese medicine. In the process of enzymatic hydrolysis and degradation, the specific activity concentration of the biological enzyme is 1-1000IU / g substrate, and the dosage is 0.5-5% of the quality of the medicinal material, preferably 0.5-2.5%, for example 1%, 1.5%, 2%, the enzymatic hydrolysis temperature can be 20-80°C, and the enzymatic hydrolysis time can be 3-144 hours.

[0035] The present invention combines the above-mentioned Chinese herbal medicines with bio-enzyme hydrolysis and degradation technology, and degrades the effective active ingredients in the Chinese herbal medicines that cannot be directly utilized after entering the human body into small molecular active substances such as oligosaccharides and low peptides that are easily soluble in solvents such as water, alcohol or glycerol through bio-enzyme hydrolysis. The small molecular active ingredients in the bio-enzyme hydrolysis products have a strong transdermal permeability effect, which can make the drug molecules fully dissolved and easily absorbed by the human body, thereby significantly improving the drug efficacy.

[0036] The present invention can also enhance the solubility of the above-mentioned Chinese herbal medicines in auxiliary materials (such as glycerol) by combining the above-mentioned Chinese herbal medicines with bio-enzyme hydrolysis and degradation technology. Experimental studies have shown that the solubility can be increased from 4-15% in the traditional decoction method to 85-99%. Due to the dissolution enhancement treatment, the dissolution rate of the active ingredients of the Chinese herbal medicines is greatly improved, from the traditional 10-50% to nearly 100%.

[0037] Because the macromolecular substances in Chinese herbal medicines - cellulose, protein, starch, etc. are converted into oligosaccharides and peptides that are easily absorbed by the human body, they are easier to be absorbed by the human body, and the absorption rate of the active ingredients is increased from 10-60% in traditional drug administration methods to nearly 100%, the efficacy is significantly improved, and the effect time is greatly shortened, thereby greatly reducing the effective therapeutic dose of Chinese herbal medicines to only 1 / 10-1 / 200 of the traditional method.

[0038] Studies have also shown that oligosaccharides and low peptides can also regulate human immune function and are used in modern medicine for immunotherapy purposes. The Chinese herbal ointment prepared by the present invention contains a large amount of oligosaccharides and low peptides, which can play an auxiliary and synergistic role.

[0039] The Chinese medicine ointment provided by the present invention, which includes the above-mentioned Chinese medicine composition and is used to prepare the Jingu Tongluo patch, can be further poured into a mold paved with a backing layer, pressed into a drug-containing paste layer, and a protective layer is pasted on the drug-containing paste layer to prepare the Jingu Tongluo patch. The backing layer can be, for example, a non-woven fabric, a synthetic fabric, etc., and the protective layer can be, for example, a polyethylene film. When applying, the polyethylene film protective layer can be torn off, and the side with the Chinese medicine ointment prepared by the present invention attached is applied to the affected area.

[0040] The Chinese medicine plaster prepared by the present invention and comprising the above-mentioned Chinese medicine composition for preparing the Jingu Tongluo patch can prevent various types of joint diseases, and has certain effects of promoting blood circulation and relieving pain, dispelling wind and removing dampness when applied externally, and has certain effects on preventing bone hyperplasia or osteoarthritis in the joints of the limbs of the body; it has a certain improvement effect on mild blood circulation disorders in muscles and other soft tissues, for example, it has a certain therapeutic effect on muscle soreness, limb soreness and fatigue caused by excessive physical fatigue; it also has a certain preventive effect on other degenerative diseases of the body such as periarthritis of the shoulder, lumbar spondylosis, cervical spondylosis, etc.

[0041] In the Chinese medicine composition with the function of promoting the flow of tendons and bones provided by the present invention, each raw material component as an active ingredient has the following expected functions:

[0042] Dried ginger:

[0043] It is the dried rhizome of Zingiber officinale Rosc., a plant of the ginger family. It is dug up in winter, the fibrous roots and sand are removed, and it is dried in the sun or at low temperature. The sliced ​​ginger that is dried in the sun or at low temperature while still fresh is called "dried ginger slices".

[0044] Properties: Flat block with finger-like branches, 3-7cm long and 1-2cm thick. The surface is grayish yellow or light grayish brown, rough, with longitudinal wrinkles and obvious links. There are often remnants of scale leaves at the branches, and there are stem scars or buds at the top of the branches. The texture is solid, the cross section is yellowish white or grayish white, powdery or granular, the inner cortex has obvious rings, and the vascular bundles and yellow oil spots are scattered. The aroma is fragrant and unique, and the taste is spicy.

[0045] Nature and flavor: pungent, hot. Enters the spleen, stomach, kidney, heart and lung meridians.

[0046] Functions and indications: warms the middle and dispels cold, restores yang and unclogs the meridians, warms the lungs and transforms fluid. Used for cold pain in the abdomen, vomiting and diarrhea, cold limbs and weak pulse, asthma and cough due to cold fluid.

[0047] safflower:

[0048] It is the dried flower of Carthamus tinctorius L., a plant of the Asteraceae family. The flowers are picked when they turn from yellow to red in summer and dried in the shade or in the sun.

[0049] Properties: Tubular flowers without ovary, 1-2 cm long. Reddish yellow or red surface. The corolla tube is slender, with 5 lobes at the tip, and the lobes are narrow strips, 5-8 mm long; 5 stamens, anthers aggregated into a tube, yellow-white; stigma is long cylindrical, slightly bifurcated at the top. Soft texture. Slightly fragrant, slightly bitter taste.

[0050] Nature and flavor: pungent, warm. Enters the heart and liver meridians.

[0051] Functions and indications: Promote blood circulation and menstruation, dissipate blood stasis and relieve pain. Used for amenorrhea, dysmenorrhea, lochia retention, lumps and masses, chest pain, abdominal pain due to stasis, stabbing pain in the chest and ribs, injuries from falls, and sores and swelling.

[0052] Cinnamon:

[0053] It is the dried bark of Cinnamomum cassia Presl, a plant of the Lauraceae family. It is usually peeled off in autumn and dried in the shade.

[0054] Properties: This product is in the shape of a groove or roll, 30-40cm long, 3-10cm wide or in diameter, and 0.2-0.8cm thick. The outer surface is gray-brown, slightly rough, with irregular fine wrinkles and transversely protruding lenticels, and some gray-white stripes can be seen; the inner surface is red-brown, slightly flat, with fine longitudinal lines, and oil marks can be seen when scratched. It is hard and brittle, easy to break, and the cross section is uneven. The outer layer is brown and rough, and the inner layer is red-brown and oily, with a yellow-brown line between the two layers. It has a strong aroma and tastes sweet and spicy.

[0055] Nature and flavor: pungent, sweet, very hot. Enters the kidney, spleen, heart and liver meridians.

[0056] Functions and indications: replenish fire and boost yang, guide fire back to the origin, dispel cold and relieve pain, warm and dredge the meridians. Used for impotence, cold uterus, cold pain in waist and knees, wheezing due to kidney deficiency, floating of false yang, dizziness and red eyes, cold pain in the heart and abdomen, vomiting and diarrhea due to deficiency and cold, abdominal pain due to cold hernia, dysmenorrhea and amenorrhea.

[0057] Chuanxiong:

[0058] It is the dried rhizome of the plant Chuanxiong Hort. of the Umbelliferae family. It is dug up in summer when the nodes on the stem are prominent and slightly purple, and the sand is removed, and the stem is dried in the sun before the fibrous roots are removed.

[0059] Properties: Irregular nodular fist-shaped masses, 2 to 7 cm in diameter. The surface is gray-brown or brown, rough and wrinkled, with many parallel raised whorls, sunken circular stem scars on the top, and many small tubercle root scars on the lower side and whorls. The texture is solid and not easy to break. The cross section is yellow-white or gray-yellow, with scattered yellow-brown oil chambers, and the cambium ring is wavy. The smell is strong and fragrant, the taste is bitter and spicy, with a slight numbing feeling on the tongue, and a slight sweet aftertaste.

[0060] Nature and flavor: pungent, warm. Enters the liver, gallbladder and pericardium meridians.

[0061] Functions and indications: Promote blood circulation and qi, dispel wind and relieve pain. Used for chest pain, chest and flank pain, swelling and pain due to falls, irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to lumps, headache, and rheumatic pain.

[0062] Eucommia ulmoides:

[0063] It is the dried bark of Eucommia ulmoides Oliv., a plant of the Eucommia family. It is peeled from April to June, the rough bark is scraped off, and it is piled up to "sweat" until the inner bark turns purple-brown, and then dried in the sun.

[0064] Properties: In the form of plates or with both sides slightly rolled inward, of varying sizes, 3 to 7 mm thick. The outer surface is light brown or grayish brown, with obvious wrinkles or longitudinal cracks. Some of the bark is thinner, with obvious lenticels visible without peeling. The inner surface is dark purple and smooth. It is brittle and easy to break. The cross section is connected by fine, silvery white, elastic rubber threads. It has a slight odor and tastes slightly bitter.

[0065] Nature and flavor: sweet, warm. Enters the liver and kidney meridians.

[0066] Functions and indications: Nourishes the liver and kidneys, strengthens the tendons and bones, and stabilizes the fetus. It is used for liver and kidney deficiency, sore waist and knees, weak tendons and bones, dizziness, bleeding during pregnancy, and restless fetus.

[0067] Angelica:

[0068] It is the dried root of Angelica sinensis (Oliv.) Diels, a plant of the Umbelliferae family. It is dug up in late autumn, the fibrous roots and sand are removed, and after the water evaporates slightly, it is tied into small bundles, put on a shed, and slowly dried with fireworks.

[0069] Properties: Slightly cylindrical, with 3 to 5 or more lateral roots at the bottom, 15 to 25 cm long. The surface is light brown to brown, with longitudinal wrinkles and long horizontal lenticel-like protrusions. The root head (guitou) is 1.5 to 4 cm in diameter, with annular patterns, blunt at the top, or with several obvious protruding rhizome marks, with purple or yellow-green stem and leaf sheath residues; the main root (guishen) has an uneven surface; the lateral root (guiwei) is 0.3 to 1 cm in diameter, thick at the top and thin at the bottom, mostly twisted, with a few fibrous root marks. It is flexible, with a yellow-white or light yellow-brown cross section, thick cortex, cracks and many brown dot-shaped secretion cavities, lighter wood color, and yellow-brown cambium ring. It has a strong aroma and tastes sweet, spicy, and slightly bitter. Those with large firewood, dry and oilless, or green-brown cross section cannot be used for medicinal purposes.

[0070] Nature and flavor: sweet, pungent, warm. Enters the liver, heart and spleen meridians.

[0071] Functions and indications: nourishing blood and activating blood circulation, regulating menstruation and relieving pain, moistening intestines and relieving constipation. Used for blood deficiency and sallow complexion, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to deficiency and cold, rheumatic arthralgia, injuries from falls, carbuncle, ulcers, dry intestines and constipation. Wine Angelica activates blood circulation and regulates menstruation. Used for amenorrhea and dysmenorrhea, rheumatic arthralgia, injuries from falls.

[0072] mastic:

[0073] It is the resin exuded from the bark of Boswellia carterii Birdw. and Boswellia bhaw-dajiana Birdw., both of which are plants of the same genus. It is divided into Somali frankincense and Ethiopian frankincense, and each type of frankincense is further divided into frankincense beads and original frankincense.

[0074] Properties: Long oval milky droplets, round particles or irregular blocks of varying sizes. The largest is up to 2cm (frankincense beads) or 5cm (original frankincense). The surface is yellowish white, translucent, covered with yellowish white powder, and the color deepens with long storage. It is brittle and softens when heated. The broken surface has a glassy or waxy luster. It has a unique aroma and tastes slightly bitter.

[0075] Nature and flavor: pungent, bitter, warm. Enters the heart, liver and spleen meridians.

[0076] Functions and indications: Promote blood circulation and relieve pain, reduce swelling and promote tissue regeneration. Used for chest pain, heart pain, stomach pain, dysmenorrhea, amenorrhea, postpartum blood stasis, abdominal pain due to lumps, rheumatic pain, tendon spasm, traumatic injury, carbuncle, swelling and ulcer.

[0077] Myrrh:

[0078] It is the dried resin of Commiphora myrrha Engl. or Commiphora molmolEngl., a plant of the olive family. It is divided into natural myrrh and colloidal myrrh.

[0079] Properties: Natural myrrh is in irregular granular masses of varying sizes, with the largest ones having a diameter of more than 6 cm. The surface is yellow-brown or reddish-brown, and the nearly translucent part is brown-black, covered with yellow dust. It is hard and brittle, with an uneven broken surface and no luster. It has a unique aroma and tastes bitter and slightly pungent. Gum myrrh is in irregular blocks and particles, mostly sticking together into masses of varying sizes, with the largest ones having a diameter of more than 6 cm, with a brown-yellow to brown-brown surface, opaque, solid or loose, with a unique aroma, bitter and sticky.

[0080] Nature and flavor: pungent, bitter, neutral. Enters the heart, liver and spleen meridians.

[0081] Functions and indications: dissipates blood stasis and relieves pain, reduces swelling and promotes tissue regeneration. Used for chest pain, heart pain, stomach pain, dysmenorrhea, amenorrhea, postpartum blood stasis, abdominal pain due to lumps, rheumatic pain, traumatic injuries, carbuncle, swelling and ulcer.

[0082] Sichuan Dipsacus:

[0083] It is the dried root of Dipsacus asper Wall.ex Henry, a plant of the Dipsacus family. It is dug up in autumn, the root head and fibrous roots are removed, and it is dried over a low fire until it is half dry. It is piled up to "sweate" until the inside turns green, and then dried again.

[0084] Properties: Cylindrical, slightly flat, some slightly curved, 5-15cm long, 0.5-2cm in diameter. The surface is gray-brown or yellow-brown, with slightly twisted or obviously twisted longitudinal wrinkles and grooves, and horizontal lenticel-like scars and a few root scars can be seen. It is soft, hardens after being left for a long time, is easy to break, and has an uneven cross section. The cortex is dark green or brown, the outer edge is brown or light brown, the wood is yellow-brown, and the duct bundles are arranged radially. It has a slight fragrance and tastes bitter, slightly sweet and then astringent.

[0085] Nature and flavor: bitter, pungent, slightly warm. Enters the liver and kidney meridians.

[0086] Functions and indications: nourish liver and kidney, strengthen tendons and bones, heal fractures, and stop metrorrhagia. It is used for liver and kidney deficiency, soreness of waist and knees, rheumatism, injuries from falls, fractures of tendons, metrorrhagia, and miscarriage. Wine-scented Dipsacus is mostly used for rheumatism, injuries from falls, fractures of tendons. Salt-scented Dipsacus is mostly used for soreness of waist and knees.

[0087] Angelica dahurica:

[0088] It is the dried root of Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f. or Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.var.formosana (Boiss.) Shan et Yuan of the Umbelliferae family. It is dug up when the leaves turn yellow in summer and autumn, the fibrous roots and mud are removed, and it is dried in the sun or at a low temperature.

[0089] Properties: Long conical, 10-25cm long, 1.5-2.5cm in diameter. Surface is gray-brown or yellow-brown, root head is blunt quadrangular or nearly circular, with longitudinal wrinkles, root branch marks and lenticel-like transverse protrusions, some arranged in four longitudinal rows. There is a sunken stem mark at the top. The texture is solid, the cross section is white or grayish white, powdery, the cambium ring is brown, nearly square or nearly circular, and there are many brown oil spots scattered on the skin. The smell is fragrant, and the taste is spicy and slightly bitter.

[0090] Nature and flavor: pungent, warm. Enters the stomach, large intestine, and lung meridians.

[0091] Functions and indications: dispel cold, dispel wind and relieve pain, clear the nasal passages, dry dampness and stop leukorrhea, reduce swelling and discharge pus. Used for colds and headaches, brow pain, nasal congestion and runny nose, allergic rhinitis, sinusitis, toothache, leukorrhea, sores and swelling.

[0092] rhubarb:

[0093] It is the dried root and rhizome of Rheum palmatum L., Rheum tanguticumMaxim.ex Balf. or Rheum officinale Baill. of the Polygonaceae family. It is dug up when the stems and leaves wither in late autumn or before germination in the next spring, the fine roots are removed, the outer skin is scraped off, the petals or segments are cut, and the dried in strings or directly dried.

[0094] Properties: cylindrical, conical, oval or irregular block, 3 to 17 cm long, 3 to 10 cm in diameter. The surface of the peel is yellow-brown to reddish brown, some with off-white reticular texture and scattered stars (heteromorphic vascular bundles), and the remaining peel is brown, with many rope holes and coarse wrinkles. The texture is solid, some with a slightly soft center, light reddish brown or yellowish brown in cross section, and granular; the rhizome has a wide pith with stars ringed or scattered; the root wood is well-developed with radial texture, the cambium ring is obvious, and there are no stars. The smell is fresh, the taste is bitter and slightly astringent, and it sticks to the teeth when chewed, and it feels like sand.

[0095] Nature and flavor: bitter, cold. Enters the spleen, stomach, large intestine, liver, and pericardium meridians.

[0096] Functions and indications: It can clear away stagnation, clear away heat and purge fire, cool blood and detoxify, remove blood stasis and promote menstruation, and remove dampness and reduce jaundice. It is used for constipation due to excess heat accumulation, vomiting and bleeding due to blood heat, red eyes and swollen throat, carbuncle, abdominal pain due to intestinal carbuncle, amenorrhea due to blood stasis, postpartum stasis, traumatic injury, damp-heat dysentery, jaundice and red urine, stranguria, edema; external treatment for burns and scalds. Wine rhubarb is good at clearing heat and toxicity from the upper part of the blood, and is used for red eyes and swollen throat, and swollen and painful gums. Cooked rhubarb has a slow laxative effect, clears fire and detoxifies, and is used for fire toxicity sores. Rhubarb charcoal cools blood, removes blood stasis and stops bleeding, and is used for blood heat with blood stasis and bleeding.

[0097] Drynaria:

[0098] It is the dried rhizome of Drynaria fortunei (Kunze) J.Sm., a plant of the Polypodiaceae family. It can be dug up throughout the year, removed from the mud and sand, dried, or the hairs (scales) are burned off.

[0099] Properties: Flat and long, mostly curved, with branches, 5-15cm long, 1-1.5cm wide, 0.2-0.5cm thick. The surface is densely covered with dark brown to dark brown small scales, soft as hair, and brown or dark brown after being burned. There are raised or sunken circular leaf marks on both sides and the upper surface, and a few have petiole residues and fibrous roots. It is light, brittle, easy to break, reddish brown in cross section, and the vascular bundles are yellow dots arranged in rings. It has a slight smell and a light, slightly astringent taste.

[0100] Nature and flavor: bitter, warm. Enters the liver and kidney meridians.

[0101] Functions and indications: Healing wounds and relieving pain, strengthening kidney and bones; external use to eliminate wind and remove spots. Used for falls, sprains, fractures of tendons and bones, kidney deficiency and low back pain, weakness of tendons and bones, tinnitus, deafness, loose teeth; external treatment of alopecia areata and vitiligo.

[0102] Acorus:

[0103] It is the dried rhizome of Acorus tatarinowii Schott, a plant of the Araceae family. It is dug in autumn and winter, the fibrous roots and mud are removed, and it is dried in the sun.

[0104] Properties: This product is flat cylindrical, mostly curved, often branched, 3-20cm long, 0.3-1cm in diameter. The surface is brown or grayish brown, rough, with unevenly dense segments, internodes 0.2-0.8cm long, with fine longitudinal lines, one side has residual fibrous roots or dot-shaped root marks; leaf scars are triangular, arranged alternately on the left and right, and some have hair-scale-like leaf base residues on them. Hard, fibrous in cross section, off-white or slightly red, with obvious endodermal rings, and many vascular bundles and brown oil cells can be seen. Aromatic, bitter, slightly spicy.

[0105] Nature and flavor: pungent, bitter, warm. Entries to the heart and stomach meridians.

[0106] Functions and indications: It can open the mind and dissipate phlegm, wake up the mind and improve intelligence, remove dampness and stimulate appetite. It is used for coma, epilepsy, forgetfulness, insomnia, tinnitus, deafness, abdominal distension without hunger, and dysentery with muteness.

[0107] Notopterygium wilfordii:

[0108] It is the dried rhizome and root of Notopterygium incisum Ting ex HTChang or Notopterygium franchetii H. de Boiss. of the Umbelliferae family. It is dug in spring and autumn, the fibrous roots and mud are removed, and it is dried in the sun.

[0109] Properties: Notopterygium wilfordii is a cylindrical, slightly curved rhizome, 4 to 13 cm long, 0.6 to 2.5 cm in diameter, with a stem scar at the top. The surface is brown to dark brown, and the outer skin is yellow where it falls off. The internodes are shortened, forming a tightly raised ring, resembling a silkworm, commonly known as "silkworm qiang"; the internodes are elongated, shaped like bamboo nodes, commonly known as "bamboo node qiang". There are many dot-shaped or tumor-like protruding root scars and brown broken scales on the nodes. The body is light, brittle, easy to break, the cross section is uneven, with many cracks, the cortex is yellow-brown to dark brown, oily, with brown oil spots, the wood is yellow-white, the rays are obvious, and the pith is yellow to yellow-brown. It has a fragrant smell and tastes slightly bitter and spicy. Broad-leaved Notopterygium wilfordii is a rhizome and root. The rhizome is cylindrical, with the remains of stem and leaf sheath at the top, and the root is conical, with longitudinal wrinkles and lenticels; the surface is brown, with dense rings near the rhizome, 8 to 15 cm long, 1 to 3 cm in diameter, commonly known as "striped qiang". Some rhizomes are thick, irregularly nodular, with several stem bases at the top, and thin roots, commonly known as "big-headed qiang". The texture is brittle, easy to break, the cross section is slightly flat, the bark is light brown, and the wood is yellow-white. The smell is light.

[0110] Nature and flavor: pungent, bitter, warm. Enters the bladder and kidney meridians.

[0111] Functions and indications: dispel cold, dispel wind and dampness, relieve pain. Used for colds, headaches, stiff neck, rheumatic pain, and shoulder and back pain.

[0112] Prepared Aconitum:

[0113] Processed Aconitum kusnezoffii is a processed product of Aconitum kusnezoffii.

[0114] Preparation: Take Aconitum kusnezoffii, separate large and small ones, soak them in water until there is no dry core inside, take them out, add water and boil until the large ones are cut open and there is no white core inside, and there is a slight numbness in the tongue when tasted, take them out, dry them until 60% dry, cut into thin slices, and dry them.

[0115] Properties: Irregularly round or nearly triangular flakes. Dark brown surface with grayish white polygonal cambium rings and dot-shaped vascular bundles, with gaps, and wrinkled or curved edges. Crisp. Slight odor, slightly spicy taste, slightly numbing tongue.

[0116] Nature and flavor: pungent, bitter, hot, toxic. Enters the heart, liver, kidney, and spleen meridians.

[0117] Aconitum kusnezoffii Reichb. is a dried root tuber of the Ranunculaceae plant. It is dug up in autumn when the stems and leaves wither, and the fibrous roots and sand are removed and dried.

[0118] Processed Chuanwu:

[0119] Processed Chuanwu is a processed product of Chuanwu.

[0120] Preparation: Take Chuanwu, separate large and small ones, soak them in water until there is no dry core inside, take them out, add water and boil them for 4-6 hours (or steam them for 6-8 hours) until the large and solid ones are cut open and there is no white core inside, and there is a slight numbness in the tongue when tasted, take them out, dry them until 60% dry, slice them, and dry them.

[0121] Properties: Irregular or long triangular flakes. Dark brown or yellowish brown surface with gray-brown cambium rings. Light, brittle, shiny cross section. Slight smell, slightly numbing tongue feeling.

[0122] Nature and flavor: pungent, bitter, hot, toxic. Enters the heart, liver, kidney, and spleen meridians.

[0123] Functions and indications: dispel wind and dampness, warm the meridians and relieve pain. Used for wind-cold-dampness arthralgia, joint pain, cold pain in the heart and abdomen, pain caused by cold hernia and anesthesia and pain relief.

[0124] Chuanwu is the dried root of Aconitum carmichaelii Debx., a plant of the Ranunculaceae family. It is dug from late June to early August, and the sub-roots, fibrous roots and mud and sand are removed, and then dried in the sun.

[0125] Datura:

[0126] It is the dried flower of Datura metel L., a plant of the Solanaceae family. It is harvested when the flowers first bloom from April to November and then sun-dried or dried at low temperature.

[0127] Properties: Mostly wrinkled into strips, the complete ones are 9-15cm long. The calyx is tubular, 2 / 5 of the length of the corolla, gray-green or gray-yellow, with 5 lobes at the tip, 5 longitudinal veins at the base, and slightly hairy on the surface; the corolla is trumpet-shaped, light yellow or yellow-brown, with 5 shallow lobes at the tip, the lobes have short tips, and there are 3 obvious longitudinal veins under the short tips, and the space between the two lobes is slightly concave; there are 5 stamens, and the filaments are attached to the corolla tube, 3 / 4 of the length of the corolla; there is 1 pistil, and the stigma is rod-shaped. The dried quality is flexible and has a specific smell; the sun-dried quality is crisp, with a slight smell and a slightly bitter taste.

[0128] Nature and flavor: pungent, warm, toxic. Enters the lung and liver meridians.

[0129] Functions and indications: Antiasthmatic and antitussive, antispasmodic and analgesic. Used for asthmatic cough, cold pain in the abdomen, rheumatic pain, slow convulsions in children, and surgical anesthesia.

[0130] Clematis:

[0131] It is the dried root and rhizome of Clematis chinensis Osbeck, Clematis chinensis Osbeck, Clematis chinensis Osbeck, Clematis chinensis Osbeck, Clematis chinensis Osbeck, Clematis chinensis Osbeck, Clematis chinensis Osbeck. It is dug up in autumn, the sand is removed, and the plant is dried in the sun.

[0132] Properties: The rhizome of Clematis is columnar, 1.5-10cm long and 0.3-1.5cm in diameter; the surface is light brown; the stem base remains at the top; the texture is relatively tough, and the cross section is fibrous; there are many fine roots on the lower side. The root is slender and cylindrical, slightly curved, 7-15cm long and 0.1-0.3cm in diameter; the surface is dark brown with fine longitudinal lines, and some of the cortex falls off, revealing the yellow-white wood; the texture is hard and brittle, easy to break, the cross section of the cortex is wider, the wood is light yellow, slightly square, and there are often cracks between the cortex and the wood. The smell is slight and the taste is light. The rhizome of Clematis chinensis is short columnar, 1-4cm long and 0.5-1cm in diameter. The root is 4-20cm long and 0.1-0.2cm in diameter; the surface is brown to brown-black; the cross section of the wood is round. The taste is salty. The rhizome of Northeast Clematis is columnar, 1-11cm long and 0.5-2.5cm in diameter. The roots are densely packed, 5 to 23 cm long, 0.1 to 0.4 cm in diameter, brownish black in appearance, and nearly round in cross section. The taste is spicy.

[0133] Nature and flavor: pungent, salty, warm. Enters the bladder meridian.

[0134] Functions and indications: dispel rheumatism and dredge meridians. Used for rheumatic pain, numbness of limbs, muscle spasm, and difficulty in flexion and extension.

[0135] Peach kernel:

[0136] It is the dried mature seeds of Prunus persica (L.) Batsch or Prunus davidiana (Carr.) Franch. of the Rosaceae family. The fruits are harvested after they are ripe, the pulp and kernel shell are removed, the seeds are taken out, and they are dried in the sun.

[0137] Properties: Peach kernel is flat and long oval, 1.2-1.8cm long, 0.8-1.2cm wide, 0.2-0.4cm thick. The surface is yellow-brown to reddish brown, with dense granular protrusions. One end is pointed, the middle part is swollen, and the other end is blunt and slightly tilted, with thin edges. There is a short linear hilum on one side of the tip, and a slightly darker and less obvious chalaza at the round end, from which many longitudinal vascular bundles are scattered. The seed coat is thin, with 2 cotyledons, off-white, and rich in oil. The smell is slight and the taste is slightly bitter. The mountain peach kernel is oval, small and thick, about 0.9cm long, about 0.7cm wide, and about 0.5cm thick.

[0138] Nature and flavor: bitter, sweet, neutral. Enters the heart, liver, and large intestine meridians.

[0139] Functions and indications: Activate blood circulation and remove blood stasis, moisten the intestines and promote bowel movements, relieve cough and asthma. Used for amenorrhea, dysmenorrhea, lumps and masses, lung and intestinal abscesses, injuries from falls, constipation caused by dry intestines, cough and asthma.

[0140] Zeeland:

[0141] It is the dried aerial part of Lycopus lucidus Turcz.var.hirtus Regel, a plant of the Lamiaceae family. It is harvested in summer and autumn when the stems and leaves are lush and then sun-dried.

[0142] Properties: The stem is square columnar, with few branches, shallow longitudinal grooves on all four sides, 50-100cm long, 0.2-0.6cm in diameter; the surface is yellow-green or purple, with obvious purple at the nodes and white hairs; the texture is brittle, the cross section is yellow-white, and the pith is hollow. The leaves are opposite, with short petioles or nearly sessile; the leaves are mostly wrinkled, and when flattened, they are lanceolate or oblong, 5-10cm long; the upper surface is black-green or dark green, the lower surface is gray-green, densely glandular, and both sides have short hairs; the tip is pointed, the base gradually narrows, and the edges are serrated. The cymes are axillary, the corolla is mostly shed, the bracts and calyx are persistent, the small bracts are lanceolate, with cilia, and the calyx is bell-shaped with 5 teeth. The smell is slight and the taste is light.

[0143] Nature and flavor: bitter, pungent, slightly warm. Enters the liver and spleen meridians.

[0144] Functions and indications: Promote blood circulation and regulate menstruation, remove blood stasis and eliminate carbuncle, promote diuresis and reduce swelling. Used for irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain caused by blood stasis after childbirth, swelling and poison caused by carbuncle, edema and ascites.

[0145] Lark:

[0146] Also known as small white wine grass, (Latin scientific name: Marsdenia longipes WTWang ex Tsiang & P.T.Li) is a climbing shrub of the genus Marsdenia in the Apocynaceae family. The taproot is bifurcated, the lateral roots are well developed, and the whole plant is hairless except for the inflorescence; the leaves are oblong to lanceolate-oblong, the lateral veins are arc-shaped and ascending, and they are net-shaped before reaching the leaf margin; the umbrella-shaped cymes are axillary, the corolla is purple-blue, the corona is attached to the back of the stamen, the lobes are oblong, the membrane at the top of the anther is higher than the corona, and the pollen mass is upright; the ovary is composed of free carpels, and the stigma is short conical; the achenes are rectangular, and the pappus is dirty white; the flowering and fruiting period is May-November.

[0147] Lark is native to North America, mainly distributed in Kunming, Dali and other provinces in Yunnan, China. It prefers warm and sunny climates, but can survive in a variety of climates from cold temperate to tropical zones. It is not very demanding on soil conditions and can grow in anything from sandy soil to clay loam, but loose, moist and fertile soil is preferred. It generally grows in cultivated land, field edges and gaps around settlements. Lark is classified as Least Concern (LC) in the IUCN Red List of Threatened Species.

[10] It generally reproduces by seed.

[0148] The National Collection of Chinese Herbal Medicines of Bailingcao records that Bailingcao is sweet, slightly bitter, astringent, warm, and poisonous. The root or the whole plant can be used as medicine, which has the effects of relaxing muscles and tendons, promoting blood circulation and stopping bleeding, replenishing deficiency, relieving cough and relieving asthma, etc. It can be used to treat rheumatism, traumatic injuries, internal bleeding, bronchitis, anemia, traumatic bleeding, fractures, rheumatic heart disease, etc. The tender stems and leaves are collected, and after removing the bitterness and odor, they can be fried and eaten, made into soup, etc. However, the plant is poisonous and should not be taken too much. After poisoning, limb convulsions will occur, which can be relieved by boiling alder leaves and hairy peaches in water.

[0149] Nature and flavor: sweet, slightly bitter, astringent, warm. Toxic.

[0150] Functions and indications: Activate blood circulation and stop bleeding, relieve cough and asthma. Used for traumatic injuries, rheumatism, internal bleeding, bronchitis, asthma; externally used to treat fractures and traumatic bleeding. Relax muscles and activate collaterals, replenish deficiency and relieve asthma.

[0151] 1. Stretching grass:

[0152] It is the dried whole herb of Lycopodium japonicum Thunb., a plant of the Lycopodium family. It is harvested in summer and autumn when the stems and leaves are lush, and then removed of impurities and sun-dried.

[0153] Properties: The stolons are thin cylindrical, slightly curved, up to 2m long, 1-3mm in diameter, with yellow-white fine roots underneath; the upright stems are bifurcated. The leaves are densely grown on the stems, arranged in a spiral, wrinkled and curved, linear or needle-shaped, 3-5mm long, yellow-green to light yellow-brown, hairless, awn-shaped at the tip, entire, and easily broken. The texture is soft, the cross section of the bark is light yellow, and the wood is off-white. The smell is slight and the taste is light.

[0154] Nature and flavor: slightly bitter, pungent, warm. Enters the liver, spleen, and kidney meridians.

[0155] Functions and indications: dispel wind and dampness, relax muscles and activate collaterals. Used for joint pain and difficulty in flexion and extension.

[0156] Treats:

[0157] It is the dried bark of Phellodendron chinense Schneid., a plant of the Rutaceae family. It is commonly known as "Sichuan Huangbai". After peeling the bark, remove the rough skin and dry it in the sun.

[0158] Properties: Plate-shaped or shallow groove-shaped, with different lengths and widths, and a thickness of 1 to 6 mm. The outer surface is yellow-brown or yellow-brown, flat or with longitudinal grooves, and some have visible lenticel marks and residual gray-brown rough skin; the inner surface is dark yellow or light brown, with fine longitudinal ridges. The body is light, hard, and the cross section is fibrous, with slit-like layers and dark yellow. It has a slight odor and tastes extremely bitter. It is sticky when chewed.

[0159] Nature and flavor: bitter, cold. Enters the kidney and bladder meridians.

[0160] Functions and indications: Clears away heat and dampness, purges fire and eliminates steam, detoxifies and treats sores. Used for damp-heat diarrhea, jaundice, red urine, vaginal discharge, itching, painful stranguria, beriberi, bone steaming, fever, night sweats, spermatorrhea, sores, swelling and poison, eczema and wet sores. Salt-coated Phellodendron nourishes yin and reduces fire. Used for yin deficiency and excessive fire, night sweats and bone steaming. 37:

[0162] It is the dried root and rhizome of Panax notoginseng (Burk.) FHChen of the Araliaceae family. It is dug up in autumn before the flowers bloom, washed, and the main root, branch roots and rhizome are separated and dried. The branch roots are commonly known as "tendons" and the rhizome is commonly known as "cut mouth".

[0163] Properties: The taproot is conical or cylindrical, 1 to 6 cm long and 1 to 4 cm in diameter. The surface is gray-brown or gray-yellow, with intermittent longitudinal wrinkles and root scars. There is a stem scar at the top, with tumor-like protrusions around. It is heavy and solid, with gray-green, yellow-green or gray-white cross-section, and the wood is slightly radially arranged. The smell is slight, and the taste is bitter and sweet. The tendons are cylindrical or conical, 2 to 6 cm long, with a diameter of about 0.8 cm at the upper end and about 0.3 cm at the lower end. The cut is irregularly wrinkled blocks or strips, with several obvious stem scars and rings on the surface, and the center of the cross-section is gray-green or white, and the edges are dark green or gray.

[0164] Nature and flavor: sweet, slightly bitter, warm. Enters the liver and stomach meridians.

[0165] Functions and indications: dissipate blood stasis and stop bleeding, reduce swelling and relieve pain. Used for hemoptysis, hematemesis, epistaxis, bloody stool, metrorrhagia, bleeding from trauma, stabbing pain in the chest and abdomen, and swelling and pain from falls.

[0166] Sumac:

[0167] It is the dried heartwood of Caesalpinia sappan L., a plant of the Leguminosae family. It is usually cut down in autumn, with the white sapwood removed and dried.

[0168] Properties: Long cylindrical or bisected semi-cylindrical, 10-100 cm long, 3-12 cm in diameter. Yellow-red to brown-red in color, with knife marks and common longitudinal cracks. Hard. Slightly shiny in cross section, with obvious annual rings, some with dark brown, loose pith with bright stars. Slight odor, slightly astringent taste.

[0169] Nature and flavor: sweet, salty, neutral. Enters the heart, liver and spleen meridians.

[0170] Functions and indications: Promote blood circulation, remove blood stasis, reduce swelling and relieve pain. Used for traumatic injuries, fractures and tendon injuries, stasis and swelling, amenorrhea, dysmenorrhea, postpartum stasis, chest and abdominal pain, carbuncle swelling and pain.

[0171] Spiced Vine:

[0172] Schisandra chinensis is an evergreen climbing shrub of the genus Schisandra in the family Magnoliaceae. The taproot is thick and cylindrical; the leaves are alternate, sub-leathery, ovate-lanceolate to oblong, acuminate at the apex, obtuse at the base, nearly entire or with sparse serrations; the flowers are unisexual and axillary, with narrow triangular bracts, triangular to nearly kidney-shaped tepals, ciliate, elliptical to ovate, and nearly spherical stamens; the berries are bright red when ripe; the flowering period is summer.

[0173] Five-spice vine is distributed in Yunnan and other provinces in China, and often grows in sunny rock crevices or bushes on hillsides.

[0174] According to the "Selected Chinese Herbal Medicines of Yunnan", five-spice vine has the effects of clearing away heat and detoxifying, relaxing muscles and activating blood circulation, reducing swelling and relieving pain. It can be used to treat influenza, venomous snakes, rabies bites, rheumatism and numbness, bruises, irregular menstruation, carbuncles and sores; the juice of its stems and vines can be boiled into chicken blood vine paste.

[0175] An evergreen climbing shrub of the genus Schisandra in the Magnoliaceae family. The taproot is thick and cylindrical. The leaves are alternate, sub-leathery, ovate-lanceolate to oblong, 5-15 cm long, acuminate at the apex, obtuse at the base, nearly entire or with sparse serrations; the flowers are unisexual, axillary, 1-2 in number, with narrow triangular bracts, about 1 mm long and wide; the outermost 3-5 tepals are small, triangular to nearly kidney-shaped, with ciliate margins, and the inner 5 tepals are purple-red, elliptical to ovate; the stamens are nearly spherical; the berries are bright red when hot; the flowering period is summer.

[0176] According to the "Selected Chinese Herbal Medicines of Yunnan", five-spice vine has the effects of clearing away heat and detoxifying, relaxing muscles and activating blood circulation, reducing swelling and relieving pain. It can be used to treat symptoms such as influenza, venomous snakes, rabies bites, rheumatism and numbness, bruises, irregular menstruation, carbuncles and sores.

[0177] The sap from the stems and branches of the five-spice vine can be boiled into chicken blood vine paste.

[0178] Astronomical grass:

[0179] Acmella ciliata (Kunth) Cass. is a perennial herb in the genus Acmella in the family Asteraceae. The stems are usually decumbent to ascending, rooting at nodes, green to purple; the leaves are ovate to broadly ovate, glabrous to sparsely pubescent on both sides, the base is usually truncate or cordate, the margins are serrated to coarsely serrated, and the apex is acute; the flowers are tubular, yellow-orange; the corolla is 5-lobed, and the lobes are triangular; the achenes are black, without shoulders, with obvious cork-shaped margins, and the margins are sparsely to moderately ciliated; the flowering period is all year round.

[0180] Astronomical grass is native to South America and is distributed in Guangdong, Guangxi, Hainan, Guizhou and other places in China. It likes to grow in fields, wet land beside roads, and grows by itself beside ditches. The general method of reproduction is seed propagation.

[0181] Tianwencao is pungent, bitter, slightly warm and slightly toxic. According to the National Compilation of Chinese Herbal Medicines, Tianwencao can relieve cough and asthma, reduce swelling and relieve pain. It can be used to treat colds, coughs, chronic bronchitis, asthma, whooping cough, tuberculosis, snake bites, sores, swelling, toothache and other symptoms. It can be taken orally or ground into powder, and can also be used for decoction or wine soaking. According to modern clinical research, it can be used to treat chronic bronchitis and can also be used for local anesthesia.

[0182] Herbs perennial, 30-80 cm tall. Stems usually decumbent to ascending, rooting at nodes, green to purple. Leaf blade ovate to broadly ovate, 2.3-7.5 × 1-5.9 cm, glabrous to sparsely pubescent on both surfaces, base usually truncate or cordate, margin denticulate to coarsely denticulated, apex acute. Inflorescence capitulate, solitary or 2 or 3, terminal or axillary; ligulate flowers 5-10, corolla yellow-orange; tubular flowers 90-177, yellow-orange. Achenes black. Corolla 5-lobed, 1.5-2 mm, tube 0.3-0.6 mm, throat 1-1.5 mm, lobes triangular, 0.2-0.4 × 0.2-0.3 mm. Achenes black, 1.4-2.2 × 0.5-1 mm, without shoulders, with distinct corky margins, margin sparsely to moderately ciliated; usually absent or with, sometimes with 2 very short, nearly equal hairs, > 1 mm. Flowering all year round.

[0183] Tianwencao is pungent, bitter, slightly warm and slightly toxic. According to the National Compilation of Chinese Herbal Medicines, Tianwencao can relieve cough and asthma, reduce swelling and relieve pain. It can be used to treat colds, coughs, chronic bronchitis, asthma, whooping cough, tuberculosis, snake bites, sores, swelling, toothache and other symptoms. It can be taken orally or ground into powder, and can also be used for decoction or wine soaking. According to modern clinical research, it can be used to treat chronic bronchitis and can also be used for local anesthesia.

[0184] Medicinal part: whole plant.

[0185] Nature and flavor: spicy, bitter, slightly warm.

[0186] Meridians: Enters the lung, stomach and spleen meridians.

[0187] Efficacy: Relieve cough and asthma, detoxify and remove dampness, reduce swelling and relieve pain.

[0188] Indications: colds, coughs, asthma, whooping cough, tuberculosis, dysentery, enteritis, sores, boils, rheumatoid arthritis, toothache, bruises, and snake bites.

[0189] Modern use: Treatment of chronic bronchitis. Used for local anesthesia.

[0190] "Handbook of Commonly Used Chinese Herbal Medicines": "It can relieve cough and asthma, reduce swelling and relieve pain. It is mainly used to treat colds and coughs, chronic bronchitis, asthma, whooping cough, tuberculosis, snake bites, sores and ulcers, and toothache."

[0191] "National Collection of Chinese Herbal Medicines": "It can detoxify and eliminate dampness, relieve cough and asthma, reduce swelling and relieve pain. It is mainly used to treat malaria, toothache, enteritis, dysentery, cough, asthma, whooping cough, and tuberculosis. It can be used externally to treat snake bites, dog bites, carbuncles, and swelling."

[0192] The present invention is further described below in conjunction with examples, the purpose of which is to better understand the content of the present invention and reflect the essential characteristics of the present invention, so the examples cited should not be regarded as limiting the scope of protection of the present invention. It is also particularly pointed out here that the specific experimental methods and equipment involved in the examples are conventional methods or implemented under the conditions recommended by the manufacturer's instructions unless otherwise specified, and the reagents involved are commercially available unless otherwise specified.

[0193] Example 1

[0194] Weigh 20 parts of dried ginger, 15 parts of safflower, 10 parts of cinnamon, 10 parts of Chuanxiong, 10 parts of Eucommia, 8 parts of Angelica, 8 parts of frankincense, 8 parts of myrrh, 8 parts of Dipsacus asper, and 5 parts of Angelica dahurica, grind them and pass through a 40-mesh sieve, add water 10 times the weight of the medicinal materials, soak for 2 hours, add 1% cellulase by weight of the medicinal materials, keep warm at 40°C for 1 hour, then heat and boil for 2 hours, collect volatile oil by steam distillation, filter the decoction, and concentrate and dry the filtrate to obtain an extract powder 1.

[0195] Weigh 10 parts of rhubarb, 10 parts of drynaria, 10 parts of calamus, 8 parts of notopterygium, 8 parts of processed aconite, 8 parts of processed Chuanwu, 8 parts of datura, 8 parts of clematis, 8 parts of peach kernel, 8 parts of zedoaria, 5 parts of larkspur, 5 parts of lycopodii, 5 parts of lycopodii, 5 parts of notoginseng, 3 parts of sappan wood, 3 parts of cinnamomum villosum, and 3 parts of astronomical herb, grind and pass through a 40-mesh sieve, add 80% ethanol (15 times the mass of water) in an ultrasonic extraction for 1 h, filter after completion of the extraction, continue to add 10 times 80% ethanol (10 times the mass of water) in an ultrasonic extraction for 0.5 h to the residue, filter after completion of the extraction, combine the two extracts, concentrate and dry the filtrate to obtain an extract powder 2.

[0196] Take borneol, vaseline, glycerin and paraffin and heat them in a water bath. After they melt, add the volatile oil, extract powder 1 and extract powder 2 obtained above, grind them evenly, and press them into shape with a mold to obtain the medicated ointment of Jingu Tongluo Patch.

[0197] Comparative Example 1 (Chinese herbal medicine decoction group)

[0198] Weigh 20 parts of dried ginger, 15 parts of safflower, 10 parts of cinnamon, 10 parts of chuanxiong, 10 parts of eucommia, 8 parts of angelica, 8 parts of frankincense, 8 parts of myrrh, 8 parts of chuanxiong, 5 parts of angelica, 10 parts of rhubarb, 10 parts of drynaria, 10 parts of calamus, 8 parts of notopterygium, 8 parts of processed aconite, 8 parts of processed chuanxiong, 8 parts of datura, 8 parts of clematis, 8 parts of peach kernel, 8 parts of zedoaria, 5 parts of larkspur, 5 parts of lycopodii, 5 parts of phellodendron, 5 parts of notoginseng, 3 parts of sappan wood, 3 parts of cinnamomea, and 3 parts of astronomical herb, grind and pass through a 40-mesh sieve, add water 10 times the mass of the medicinal materials and soak for 2 h, then heat and decoct for 4 h, collect volatile oil by steam distillation at the same time, filter the decoction, and concentrate and dry the filtrate to obtain an extract powder.

[0199] Take borneol, vaseline, glycerin and paraffin and heat them in a water bath. After they melt, add the volatile oil and extract powder obtained above, grind them evenly, and press them into shape with a mold to obtain the product.

[0200] Comparative Example 2 (without adding cellulase group)

[0201] Weigh 20 parts of dried ginger, 15 parts of safflower, 10 parts of cinnamon, 10 parts of chuanxiong, 10 parts of eucommia, 8 parts of angelica, 8 parts of frankincense, 8 parts of myrrh, 8 parts of chuanxiong, and 5 parts of angelica, grind them and pass them through a 40-mesh sieve, add water 10 times the mass of the medicinal materials and soak them for 2 hours, then heat and boil for 2 hours, collect volatile oil by steam distillation, filter the decoction, and concentrate and dry the filtrate to obtain an extract powder 1.

[0202] Weigh 10 parts of rhubarb, 10 parts of drynaria, 10 parts of calamus, 8 parts of notopterygium, 8 parts of processed aconite, 8 parts of processed Chuanwu, 8 parts of datura, 8 parts of clematis, 8 parts of peach kernel, 8 parts of zedoaria, 5 parts of larkspur, 5 parts of lycopodii, 5 parts of lycopodii, 5 parts of notoginseng, 3 parts of sappan wood, 3 parts of cinnamomum villosum, and 3 parts of astronomical herb, grind and pass through a 40-mesh sieve, add 80% ethanol (15 times the mass of water) in an ultrasonic extraction for 1 h, filter after completion of the extraction, continue to add 10 times 80% ethanol (10 times the mass of water) in an ultrasonic extraction for 0.5 h to the residue, filter after completion of the extraction, combine the two extracts, concentrate and dry the filtrate to obtain an extract powder 2.

[0203] Take borneol, vaseline, glycerin and paraffin and heat them in a water bath. After they melt, add the volatile oil, extract powder 1 and extract powder 2 obtained above, grind them evenly, and press them into shape with a mold to obtain the medicated ointment of Jingu Tongluo Patch.

[0204] Efficacy test:

[0205] The drug-containing pastes prepared in the above embodiments and comparative examples are made into tendon and bone dredging patches, and the preparation process is as follows: a non-woven fabric backing layer is placed at the bottom of a mold, the prepared drug-containing paste is poured into the mold, pressed into a drug-containing paste layer, and a polyethylene film protective layer is pasted on the drug-containing paste layer to obtain a tendon and bone dredging patch.

[0206] 1. The Jingu Tongluo patch of the above embodiment and comparative example was used for efficacy test on pain in neck, shoulder, waist, knee joint and limbs:

[0207] (1) Patient information:

[0208] The treatment population is concentrated in the age range of 18-80 years old, and 150 patients were randomly selected to observe the effect of use.

[0209] (2) Test method:

[0210] Patients with pain in the neck, shoulder, waist, knee joint and limbs were divided into 3 groups, and each group of patients used the Jingu Tongluo patch of the above embodiment 1, comparative example 1 and comparative example 2 respectively. There were 10 patients with pain in the neck, shoulder, waist, knee joint and limbs in each group. There were no significant differences in the basic conditions, age and course of disease of the patients in each group. The sample was applied to the affected area, and the use area was cleaned after 72 hours of use to avoid itching. A product was reapplied after an interval of 12 hours, and the test was performed after 4 patches were used continuously.

[0211] The testers scored based on the usage effects on a 10-point scale, with 1 being the worst and 10 being the best. The final result was the average.

[0212] The results of each evaluation index are shown in Table 1.

[0213] Table 1

[0214] Performance Test Results Example 1 Comparative Example 1 Comparative Example 2 Patients with cervical spondylosis 9.6 6.4 7.2 Patients with frozen shoulder 9.2 6.2 7.5 Lumbar spine patients 9.4 6.5 6.9 Patients with joint pain 8.7 5.9 6.5 Patients with limb pain 9.5 6.8 7.3

[0215] 2. The Jingu Tongluo patch of the above embodiment and comparative example was used to test the efficacy of pain, swelling and fatigue of the knee joint:

[0216] (1) Patient information:

[0217] The treatment population was concentrated in the age range of 18-80 years old, and 90 patients were randomly selected to observe the effect of use.

[0218] (2) Test method:

[0219] The patients with pain, distending pain and fatigue of the knee joint were divided into 3 groups, and each group of patients used the Jingu Tongluo patch of the above embodiment 1, comparative example 1 and comparative example 2 respectively. There were 10 cases of pain, distending pain and fatigue of the knee joint in each group. There were no significant differences in the basic conditions, age and course of disease of the patients in each group. After 72 hours of use, the use site was cleaned to avoid itching, and a product was reapplied after an interval of 12 hours, and the test was performed after 4 patches were used continuously.

[0220] The testers scored based on the usage effects on a 10-point scale, with 1 being the worst and 10 being the best. The final result was the average.

[0221] The results of each evaluation index are shown in Table 2.

[0222] Table 2

[0223]

[0224]

[0225] 3. The efficacy of the Jingu Tongluo patch of the above embodiment and comparative example in relieving pain of athletes after long-distance running was tested:

[0226] (1) Patient information:

[0227] The treatment population is concentrated on athletes between the ages of 18 and 80, and 30 patients with muscle soreness after long-distance running were randomly selected to observe the effects of use.

[0228] (2) Test method:

[0229] Patients with muscle soreness after long-distance running were divided into 3 groups, and each group of patients used the Jingu Tongluo patch of the above embodiment 1, comparative example 1 and comparative example 2 respectively. There were 10 patients with muscle soreness after long-distance running in each group. There were no significant differences in the basic conditions, age and course of disease of the patients in each group. After 72 hours of use, the use area was cleaned to avoid itching, and a new product was applied after an interval of 12 hours, and the test was performed after 4 consecutive patches.

[0230] The testers scored based on the usage effects on a 10-point scale, with 1 being the worst and 10 being the best. The final result was the average.

[0231] The results of each evaluation index are shown in Table 3.

[0232] Table 3

[0233] Performance Test Results Example 1 Comparative Example 1 Comparative Example 2 Muscle soreness after long run 9.3 6.2 7.3

[0234] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition having the effect of promoting the flow of tendons and bones, characterized in that: The invention comprises the following raw materials in parts by weight: 10-30 parts by weight of dried ginger, 10-20 parts by weight of safflower, 5-15 parts by weight of cinnamon bark, 5-15 parts by weight of chuanxiong rhizome, 5-15 parts by weight of eucommia bark, 5-10 parts by weight of angelica sinensis, 5-10 parts by weight of frankincense, 5-10 parts by weight of myrrh, 5-10 parts by weight of chuanxiong, 5-10 parts by weight of angelica dahurica, 5-10 parts by weight of rhubarb, 5-15 parts by weight of drynaria, 5-15 parts by weight of calamus by weight, 5-10 parts by weight of Notopterygium wilfordii, 5-10 parts by weight of processed Aconitum kusnezoffii, 5-10 parts by weight of processed Chuanwuji, 5-10 parts by weight of Datura stramonium, 5-10 parts by weight of Clematis chinensis, 5-10 parts by weight of peach kernel, 5-10 parts by weight of Eupatorium fortunei, 3-8 parts by weight of Herba Lycopodii, 3-8 parts by weight of Herba Lycopodii, 3-8 parts by weight of Phellodendron chinense, 3-8 parts by weight of Notoginseng, 3-8 parts by weight of Sappan wood, 3-8 parts by weight of Caulis dasyphyllae, and 3-8 parts by weight of Herba Astronomicae.

2. The Chinese medicine composition having the effect of dredging tendons and bones according to claim 1, characterized in that: The traditional Chinese medicine composition comprises one or more of the powder of each raw material medicine, water or organic solvent extract of each raw material medicine and biological enzyme hydrolyzate of each raw material medicine.

3. The Chinese medicine composition having the effect of dredging tendons and bones according to claim 2, characterized in that: The biological enzyme used in the biological enzyme hydrolysis product of the raw material drug is selected from one or more of protease, cellulase, amylase, lipase and lysozyme, preferably cellulase.

4. The Chinese medicine composition having the effect of promoting the flow of tendons and bones according to any one of claims 1 to 3, characterized in that: include: (1) Enzyme hydrolyzates of the following Chinese medicinal ingredients in parts by weight: 10-30 parts by weight of dried ginger, 10-20 parts by weight of safflower, 5-15 parts by weight of cinnamon bark, 5-15 parts by weight of chuanxiong, 5-15 parts by weight of eucommia bark, 5-10 parts by weight of angelica sinensis, 5-10 parts by weight of frankincense, 5-10 parts by weight of myrrh, 5-10 parts by weight of dipsaccharum officinale, and 5-10 parts by weight of angelica dahurica; and (2) The following parts by weight are the water or organic solvent extracts of each Chinese medicinal ingredient: 5-15 parts by weight of rhubarb, 5-15 parts by weight of drynaria, 5-15 parts by weight of calamus, 5-10 parts by weight of notopterygium, 5-10 parts by weight of processed aconite, 5-10 parts by weight of processed chuanwu, 5-10 parts by weight of datura, 5-10 parts by weight of clematis, 5-10 parts by weight of peach kernel, 5-10 parts by weight of zedoaria, 3-8 parts by weight of larkspur, 3-8 parts by weight of lycopodii, 3-8 parts by weight of phellodendron, 3-8 parts by weight of notoginseng, 3-8 parts by weight of sappan wood, 3-8 parts by weight of cinnamomum villosum, and 3-8 parts by weight of aster.

5. A Chinese medicine ointment for preparing a Jingutongluo patch, characterized in that: The invention comprises a traditional Chinese medicine composition having the function of promoting tendons and bones and dredges as claimed in any one of claims 1 to 3.

6. The Chinese medicine plaster for preparing Jingutongluo patch according to claim 4, characterized in that: Also included are pharmaceutically acceptable excipients, which include at least one of an inert diluent, a dispersant and / or a granulating agent, a surfactant and / or an emulsifier, a disintegrant, a binder, a preservative, a buffer, a lubricant and / or a lubricating oil.

7. The Chinese medicine plaster for preparing Jingutongluo patch according to claim 5, characterized in that: The auxiliary materials include borneol, vaseline, glycerin and paraffin.

8. A method for preparing a traditional Chinese medicine plaster for preparing a Jingu Tongluo patch according to any one of claims 5 to 7, characterized in that: The steps include: Step (1), weighing dried ginger, safflower, cinnamon bark, chuanxiong, eucommia bark, angelica sinensis, frankincense, myrrh, chuanxiong and angelica dahurica according to the proportion, crushing, passing through a 40-mesh sieve, soaking in 5-10 times of water, adding cellulase, heating and boiling, collecting volatile oil by steam distillation, filtering the decoction, concentrating and drying the filtrate to obtain an extract powder 1; Step (2), according to the proportion, weigh rhubarb, drynaria, calamus, notopterygium, processed aconite, processed Chuanwu, datura, clematis, peach kernel, zedoaria, larkspur, lycopodii, phellodendron, phellodendron, notoginseng, sappan wood, cinnamomea glutinosa and astronomical herb, crush, pass through a 40-mesh sieve, add 10-15 times of 50-80% ethanol, ultrasonically extract, filter, add 10-15 times of 50-80% ethanol to the residue, ultrasonically extract, filter, combine the two extracts, concentrate and dry the filtrate to obtain extract powder 2; Step (3), heating borneol, vaseline, glycerin and paraffin in a water bath, adding the volatile oil, extract powder 1 and extract powder 2 obtained above after melting, grinding evenly, and pressing into shape with a mold to obtain the Chinese medicine ointment for preparing the Jingu Tongluo patch.

9. The preparation method according to claim 8, characterized in that: The amount of the cellulase used is 0.5-5% of the drug material, preferably 0.5-2.5%.

10. The preparation method according to claim 8, characterized in that: In step (1), after adding cellulase, the temperature of heating and decocting is 20-80° C. and the time is 3-144 hours.

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