Traditional Chinese medicine composition for treating chronic heart failure and application thereof

Abstract

The invention relates to a traditional Chinese medicine composition for treating chronic heart failure and application thereof, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition for treating chronic heart failure is prepared from the following raw materials: prepared radix aconiti lateralis preparata, rhizoma zingiberis, honey-fried licorice root, ginseng, fructus corni, cassia twig, poria cocos, rhizoma atractylodis macrocephalae, radix salviae miltiorrhizae and agilawood. The invention further provides application of the traditional Chinese medicine composition for treating the chronic heart failure, the traditional Chinese medicine composition is used for preparing a decoction, and the obtained yang-restoring heart-rescuing decoction has the effects of warming and dredging heart yang, activating blood and inducing diuresis and is mainly used for treating the chronic heart failure caused by deficiency of heart yang and blood stasis and water retention. The traditional Chinese medicine composition has the effects of improving the heart function, reducing NT-proBNP, increasing the ejection fraction of the heart, improving the living quality of a patient and the like, and has the advantages of few side effects, high safety and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for treating chronic heart failure and application thereof. Background Art

[0002] Heart failure (HF) is a serious and terminal stage of various heart diseases. HF has high morbidity, high mortality, high re-hospitalization rate and high treatment costs. At the same time, the side effects of Western medicine treatment of HF, such as diuretic resistance and electrolyte imbalance, cannot be ignored.

[0003] At present, the treatment of chronic heart failure in Western medicine guidelines is mainly based on the new quadruple regimen, including angiotensin receptor neprilysin inhibitor (ARNI) or angiotensin converting enzyme inhibitor (ACEI) or angiotensin II receptor antagonist (ARB), sodium-glucose cotransporter 2 inhibitor (SGLT2i), beta-blocker and aldosterone receptor antagonist (MRA). Although Western medicine has certain advantages and effects in the treatment of chronic heart failure, it also has certain limitations. For example, for elderly patients with heart failure with normal left ventricular ejection fraction, beta-blockers cannot reduce their mortality and (or) re-hospitalization rate; for patients with hemodynamic instability, intravenous beta-blockers will increase the risk of cardiogenic shock and increase mortality. ACEI can cause irritating dry cough and fatal laryngeal edema. The use of aldosterone antagonist spironolactone can cause hyperkalemia, male breast hyperplasia, sexual dysfunction, etc. In addition, heart failure is a chronic disease, and long-term medication is prone to drug resistance, and it is easy to cause hypotension, cough, water and electrolyte imbalance, etc., which affects the treatment effect.

[0004] Therefore, finding safe, effective treatments with few side effects has always been a research focus in the medical community. Summary of the invention

[0005] In order to solve the above technical problems, the purpose of the present invention is to provide a Chinese medicine composition for treating chronic heart failure and its application, and through the Chinese medicine composition of the present invention, an optimized idea and drug treatment selection are provided for the prevention and treatment of chronic heart failure. The present invention also prepares a Huiyang Jiuxin Decoction, which has the effects of warming and promoting heart yang, promoting blood circulation and promoting diuresis, and mainly treats chronic heart failure caused by deficiency of heart yang, blood stasis and water retention, and has simple preparation, no side effects and good therapeutic effect.

[0006] The technical solution of the present invention to solve the above technical problems is as follows:

[0007] The first object of the present invention is to provide a traditional Chinese medicine composition for treating chronic heart failure, comprising the following raw materials: cooked aconite root, dried ginger, roasted licorice root, ginseng, cornus officinalis, cassia twig, tuckahoe, atractylodes macrocephala, salvia miltiorrhiza, and agarwood.

[0008] Cooked aconite root: very spicy, hot, toxic, enters the heart, spleen, and kidney meridians. It has the effects of restoring yang, warming the spleen and kidneys, dispelling cold and relieving pain.

[0009] Dried ginger: spicy, warm in nature, enters the spleen, stomach, kidney, heart, and lung meridians. It has the effects of warming the middle and dispelling cold, restoring yang and unblocking meridians, and warming the lungs and transforming phlegm.

[0010] Roasted Licorice: Sweet in taste, warm in nature, enters the heart meridian, lung meridian, stomach meridian and spleen meridian. It has the effects of strengthening the spleen and replenishing qi, relieving cough and asthma, clearing away heat and detoxifying, relieving pain and harmonizing the properties of medicines.

[0011] Ginseng: sweet, slightly bitter, slightly warm in nature, enters the spleen, lung, heart, and kidney meridians. It has the effects of greatly replenishing vital energy, restoring pulse and strengthening deficiency, nourishing spleen and lungs, promoting body fluid and nourishing blood, calming the mind and improving intelligence.

[0012] Cornus officinalis: sour and astringent, warm in nature, enters the liver and kidney meridians. It has the effects of nourishing the liver and kidney, astringing the essence and consolidating the loss of blood, stopping leukorrhea, stopping metrorrhagia, astringing and stopping sweating, and promoting body fluid and quenching thirst.

[0013] Cinnamon twig: spicy, sweet, warm in nature, enters the heart, lung, and bladder meridians. It has the effects of sweating, relieving muscles, warming the meridians and unblocking blood vessels.

[0014] Poria: Sweet, light, neutral in nature. Enters the heart, lung, spleen, and kidney meridians. Has the effects of promoting diuresis and eliminating dampness, strengthening the spleen and stomach, and calming the mind.

[0015] Atractylodes macrocephala: bitter, sweet, warm in nature, enters the spleen and stomach meridians. It has the effects of replenishing qi and strengthening the spleen, drying dampness and promoting diuresis, stopping sweating, and calming the fetus.

[0016] Danshen: bitter, slightly cold, enters the heart and liver meridians. It has the effects of relieving pain, promoting blood circulation and removing blood stasis, cooling blood, clearing the heart and eliminating troubles, and eliminating carbuncle.

[0017] Agarwood: Spicy, bitter, slightly warm in nature, enters the spleen, stomach, and kidney meridians. It has the effects of promoting qi and relieving pain, warming the middle and stopping vomiting, and relieving asthma.

[0018] The beneficial effects of the present invention are as follows: in the Chinese medicine composition of the present invention, cooked aconite is used as a raw material, which is very pungent and hot, enters the heart, spleen and kidney meridians, warms and unblocks the heart yang, warms the kidney and strengthens yang, and promotes the heart yang, so that the root is born and it is endless; dried ginger is also a pungent and hot product, belongs to the lung, spleen and heart meridians, can warm the middle and dispel cold, help yang and dredge the meridians, so the two are the main medicines. Dried ginger and cooked aconite are used together, and the power of helping yang and dispersing cold is particularly large, so there is a saying that "aconite is not hot without ginger". Ginseng strengthens the spleen and replenishes qi, cornus astringes and consolidates, and salvia miltiorrhiza promotes blood circulation and removes blood stasis, and the three are the ministers. Assisted with cinnamon twig to help yang and transform qi, there are also poria and atractylodes to promote diuresis and remove dampness, and roasted licorice is warm and nourishing, nourishes the spleen and stomach and adjusts various medicines, and can slow down the dry and pungent nature of ginger and aconite, so that it breaks yin and restores yang without the risk of dissipation. The four medicines are the classic prescription Ling Gui Zhu Gan Tang in Synopsis of the Golden Chamber, which has the effects of warming yang, transforming water retention, strengthening the spleen and removing dampness. Agarwood is used as an adjuvant to absorb qi and relieve asthma. The combination of these medicines can invigorate the heart yang, remove water retention, and transform blood stasis, and play the role of warming the heart yang, promoting blood circulation and relieving asthma. Huiyang Jiuxin Decoction contains Sini Tang, which is composed of aconite, dried ginger and licorice. Modern pharmacological studies have found that Sini Tang has the effects of improving cardiac function, resisting oxidative stress, resisting myocardial fibrosis, improving hemodynamics, resisting atherosclerosis, protecting immune response, inhibiting tumor growth and protecting renal function. In addition, relevant studies have found that ginseng has the effects of enhancing myocardial contractility, resisting myocardial ischemia, and enhancing immune function. Salvia miltiorrhiza has the effects of protecting vascular endothelial cells, promoting vascular endothelial repair, inhibiting vascular smooth muscle cell proliferation, inhibiting inflammatory response, resisting peroxidation damage, and inhibiting platelet aggregation. Cornus officinalis has an antioxidant effect, and cinnamon twig has the effects of promoting vasodilation, diuresis, and anti-inflammatory effects. Atractylodes macrocephala and Poria cocos can reduce the release of inflammatory factors and improve inflammatory responses. Agarwood can relieve asthma and pain, and lower blood pressure.

[0019] Traditional Chinese medicine has rich practical experience in the prevention and treatment of heart failure. Based on previous research results, it was found that "heart yang deficiency, blood stasis and water retention" is the main pathogenesis of chronic heart failure, and warming the heart yang and promoting blood circulation and diuresis are the main treatment methods. However, under the guidance of the theory of combining disease and syndrome, there is no literature report on the clinical randomized controlled study of Huiyang Jiuxin Decoction in the treatment of patients with chronic heart failure, and there is no literature report on the drug composition and dosage of Huiyang Jiuxin Decoction. Huiyang Jiuxin Decoction provides further clinical evidence for the treatment of chronic heart failure, and on the basis of randomized controlled comparison, it provides an optimized idea and drug treatment option for the prevention and treatment of chronic heart failure.

[0020] Based on the above technical solution, the present invention can also be improved as follows.

[0021] Furthermore, the Chinese medicine composition includes the following raw materials in parts by weight: 8 to 20 parts of cooked aconite root, 5 to 20 parts of dried ginger, 4 to 30 parts of roasted licorice root, 5 to 15 parts of ginseng, 5 to 15 parts of cornus officinalis, 5 to 15 parts of cinnamon twig, 3 to 18 parts of poria, 3 to 18 parts of atractylodes macrocephala, 3 to 30 parts of salvia miltiorrhiza, and 1 to 5 parts of agarwood.

[0022] Furthermore, the Chinese medicine composition includes the following raw materials in parts by mass: 10 to 15 parts of cooked aconite root, 10 to 15 parts of dried ginger, 10 to 15 parts of roasted licorice root, 8 to 12 parts of ginseng, 9 to 12 parts of cornus officinalis, 5 to 12 parts of cinnamon twig, 6 to 16 parts of poria, 3 to 10 parts of atractylodes macrocephala, 9 to 20g parts of salvia miltiorrhiza, and 2 to 5 parts of agarwood.

[0023] The second object of the present invention is to provide an application of a traditional Chinese medicine composition for treating chronic heart failure, wherein the traditional Chinese medicine composition is used in preparing a medicine for treating chronic heart failure.

[0024] The beneficial effects of adopting the above-mentioned further scheme are: This study attaches importance to "internal stasis of blood, internal retention of water and deficiency of Yang Qi" according to the changes in the pathogenesis of chronic heart failure, follows the development law of the pathogenesis of chronic heart failure, and proposes the clinical efficacy and safety of Huiyang Jiuxin Decoction for chronic heart failure of yang deficiency, blood stasis and water retention type, which provides evidence-based medicine evidence for explaining the multi-target protective effects of traditional Chinese medicine for warming Yang, promoting blood circulation and promoting diuresis, and is of innovative significance.

[0025] Furthermore, the dosage form of the drug includes at least one of decoction, granules, powder, tablets, and capsules.

[0026] Furthermore, the dosage form of the medicine is a decoction.

[0027] Furthermore, the preparation method of the decoction is as follows: weigh cooked aconite root, dried ginger, roasted licorice, ginseng, cornus officinalis, cinnamon twig, poria, atractylodes macrocephala, salvia miltiorrhiza, and agarwood to obtain a mixture, add water and decoct the mixture for 1 to 3 times, filter after decoction, combine the decoctions obtained each time and filter, so as to obtain Huiyang Jiuxin Decoction in the form of a decoction.

[0028] The beneficial effect of adopting the above further scheme is that the decoction of the present invention has the effects of warming and promoting the flow of heart yang, promoting blood circulation and promoting diuresis. Through randomized controlled trials, it is concluded that Huiyang Jiuxin Decoction has a good clinical efficacy in the treatment of chronic heart failure of yang deficiency, blood stasis and water retention type, and has the effects of improving cardiac function, reducing NT-proBNP, increasing cardiac function test indicators such as cardiac ejection fraction, and improving the quality of life of patients, as well as having the advantages of fewer side effects and higher safety.

[0029] Furthermore, the mixture is decocted for 1 to 4 hours.

[0030] Furthermore, the decoction temperature is 90-110°C.

[0031] Furthermore, the decocting temperature is 100°C.

[0032] Furthermore, the usage ratio of the mixture to water is 1:8-12.

[0033] Furthermore, the ratio of the mixture to water is 1:10. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 This is a diagram of the medicinal materials in Huiyang Jiuxin Decoction according to Example 1 of the present invention;

[0035] Figure 2 This is the formula composition of Huiyang Jiuxin Decoction according to the embodiment of the present invention. DETAILED DESCRIPTION

[0036] The principles and features of the present invention are described below, and the examples are only used to explain the present invention and are not used to limit the scope of the present invention. If no specific technology or conditions are specified in the embodiments, the technology or conditions described in the literature in this field or the product instructions are used. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased through regular channels.

[0037] Example 1: Preparation of Huiyang Jiuxin Decoction

[0038] Weigh 10g of cooked aconite root, 10g of dried ginger, 10g of roasted licorice root, 9g of ginseng, 10g of cornus officinalis, 6g of cinnamon twig, 8g of poria, 4g of atractylodes macrocephala, 10g of salvia miltiorrhiza, and 3g of agarwood. Figure 1 As shown, mixing is performed to obtain a mixture, such as Figure 2 As shown, the mixture was decocted with water three times, 1000 mL of water was added each time, and decocted at 100° C. for 20 to 30 minutes each time. The decoctions were combined and filtered to obtain, and the filtrate was concentrated to 300 ml to obtain Huiyang Jiuxin Decoction.

[0039] Example 2: Preparation of Huiyang Jiuxin Decoction

[0040] Weigh 15 g of cooked aconite root, 15 g of dried ginger, 15 g of roasted licorice root, 9 g of ginseng, 10 g of cornus officinalis, 6 g of cinnamon twig, 8 g of poria, 4 g of atractylodes macrocephala, 10 g of salvia miltiorrhiza, and 3 g of agarwood to mix to obtain a mixture, and decoct the mixture three times with 1000 mL of water each time, and decoct for 20 to 30 minutes each time at 100° C., combine the decoctions, filter to obtain, and concentrate the filtrate to 300 ml to obtain Huiyang Jiuxin Decoction.

[0041] Example 3: Preparation of Huiyang Jiuxin Decoction

[0042] Weigh 10 g of cooked aconite root, 10 g of dried ginger, 10 g of roasted liquorice root, 9 g of ginseng, 10 g of cornus officinalis, 6 g of cinnamon twig, 8 g of poria, 4 g of atractylodes macrocephala, 20 g of salvia miltiorrhiza, and 3 g of agarwood, mix them to obtain a mixture, add water to the mixture and boil it three times, adding 1000 mL of water each time, boiling each time at 100° C. for 20 to 30 minutes, combining the decoctions, filtering to obtain, and concentrating the filtrate to 300 ml to obtain Huiyang Jiuxin Decoction.

[0043] Example 4: Preparation of Huiyang Jiuxin Decoction

[0044] Weigh 10 g of cooked aconite root, 10 g of dried ginger, 10 g of roasted licorice root, 9 g of ginseng, 10 g of cornus officinalis, 12 g of cinnamon twig, 16 g of poria, 8 g of atractylodes macrocephala, 10 g of salvia miltiorrhiza, and 3 g of agarwood, mix them to obtain a mixture, add water to the mixture and boil it three times, adding 1000 mL of water each time, and boil it at 100° C. for 20 to 30 minutes each time. Combine the decoctions, filter to obtain, and concentrate the filtrate to 300 ml to obtain Huiyang Jiuxin Decoction.

[0045] Clinical data:

[0046] The present invention evaluates the clinical efficacy and safety of the drug combination of the present invention in treating chronic heart failure by observing the effects of each treatment group on the serum NT-pro BNP content and cardiac ultrasound indexes (LVEF, i.e., left ventricular ejection fraction, with a normal range of 50%-70%), New York Heart Function Classification (NYHA), 6-minute walk test distance (6MWT), Minnesota Heart Failure Quality of Life Scale (MLHF-Q) score, and clinical efficacy (i.e., TCM syndrome efficacy evaluation: efficacy index n=(pre-treatment score-post-treatment score) / pre-treatment score×100%) of CHF patients.

[0047] (1) Diagnostic criteria

[0048] Meet the diagnostic criteria of Western medicine (refer to the "Guidelines for the Diagnosis and Treatment of Heart Failure in China 2024"), and also meet the symptoms of palpitations, fatigue and shortness of breath, wheezing when moving, dark complexion, bluish lips and nails, oliguria, abdominal distension, and lower limb edema. The tongue is fat, the tongue is dark purple or has petechiae and ecchymoses, and the pulse is slow, astringent, or intermittent (refer to the "Guidelines for the Diagnosis and Treatment of Chronic Heart Failure in Traditional Chinese Medicine in 2022").

[0049] (2) General Information

[0050] The cases were from patients diagnosed with chronic heart failure of yang deficiency, blood stasis and water retention type who were hospitalized or outpatients in Chongqing Traditional Chinese Medicine Hospital from January 2004 to June 2005, aged 67 to 78 years. A total of 150 cases were randomly divided into treatment groups 1 to 4 and a control group, with 30 people in each group, and the study time was 28 days.

[0051] (3) Treatment methods

[0052] Control group: The control group received conventional Western medicine treatment drugs ARNI: sacubitril valsartan, 25-100 mg, bid; β-blocker: metoprolol succinate sustained-release tablets, 11.875-47.5 mg, qd; SGLT2i: empagliflozin, 5-10 mg, qd; diuretic: spironolactone, 10-20 mg, qd. (Refer to "Guidelines for the Diagnosis and Treatment of Heart Failure in China 2024").

[0053] Treatment groups 1-4: In addition to the treatment of the control group, treatment groups 1-4 were treated with Huiyang Jiuxin Decoction orally every day, 100 ml, tid.

[0054] After 28 days of treatment, the changes in N-terminal pro-brain natriuretic peptide (NT-proBNP), New York heart function classification (NYHA), 6-minute walk test distance (6MWT), cardiac ultrasound index (LVEF, i.e., left ventricular ejection fraction, the normal range of left ventricular ejection fraction is 50%-70%), and Minnesota Heart Failure Quality of Life Scale (MLHF-Q) scores of the patients in the control group and treatment groups 1 to 4 before and after treatment were observed to evaluate the clinical efficacy and safety of the Huiyang Jiuxin Decoction of the present invention in the treatment of chronic heart failure. The test results are shown in Table 2:

[0055] Table 1

[0056]

[0057] Table 2

[0058]

[0059] It can be seen from Table 2 that: Through control experiments, it can be seen that Huiyang Jiuxin Decoction has a good clinical efficacy in the treatment of chronic heart failure of yang deficiency, blood stasis and water retention type. It has the effects of improving cardiac function, reducing NT-proBNP, increasing cardiac function test indicators such as cardiac ejection fraction, and improving the quality of life of patients. It also has the advantages of fewer side effects and higher safety.

[0060] Typical cases:

[0061] (1) On March 20, 2023, the inpatient Huang, male, 72 years old, presented with the following complaints: repeated fatigue and shortness of breath for 3 years, which worsened for 1 week.

[0062] Medical history summary: Three years ago, the patient experienced heart fatigue and shortness of breath without obvious causes, chest pain, palpitations, precordial squeezing, cough, hemoptysis, night sweats, fever, dizziness, etc. The patient was treated in another hospital and diagnosed with "chronic heart failure, heart function grade III, coronary atherosclerotic heart disease". After treatment, the patient's condition improved and he was discharged from the hospital. After discharge, the above symptoms recurred and could be triggered by mild physical activity. One week ago, the patient experienced heart fatigue again without obvious causes, accompanied by bilateral dorsum edema. Past history: 5-year history of hypertension.

[0063] The four diagnostic features of traditional Chinese medicine: dull complexion, shortness of breath, pale purple lips and nails, fat tongue, dark purple tongue with petechiae, and deep and sluggish pulse.

[0064] Physical examination: medium build, no congestion in the pharynx, no positive signs in the heart and lungs, flat and soft abdomen, no tenderness or rebound pain. The dorsum of both feet was slightly edematous.

[0065] Auxiliary examination: NT-proBNP: 4715.6ng / L, heart EF value: 47%, NYHA heart function classification: Class III, 6-minute walking test (meters): 442 meters, Minnesota scale (points): 74 points. After admission, Huiyang Jiuxin Decoction was given. After discharge, Huiyang Jiuxin Decoction was continued for consolidation treatment, with a course of 28 days.

[0066] Treatment plan: Take the Huiyang Jiuxin Decoction prepared in Example 1 orally three times a day, morning, noon and evening, 100 ml each time, warm after meals. Avoid spicy and cold food during medication, avoid wind and cold, regulate emotions, and be careful in daily life.

[0067] Treatment effect: After taking the medicine for 28 days, the patient's symptoms of wheezing and shortness of breath improved, and there was no obvious edema on the dorsum of both feet. TCM four examinations: complexion was ruddy compared with before, tongue was fat, tongue was pale purple with petechiae, and pulse was sluggish. Re-examination auxiliary examinations: NT-proBNP: 897.2ng / L, heart EF value: 54%, NYHA heart function classification: II, 6-minute walking test (meters): 523 meters, Minnesota scale (points): 63 points.

[0068] (2) On April 24, 2023, the inpatient Lv, male, 56 years old, complained of repeated wheezing and shortness of breath for more than two years, which worsened for 10 days. Medical history summary: Two years before admission, the patient had wheezing and shortness of breath without obvious causes. The symptoms occurred even when at rest, and were worse when moving. He sat up to breathe and could not lie flat, accompanied by chest tightness and edema of both lower limbs. He did not cough or cough up pink foamy sputum, nor was he afraid of cold or fever, and had no impaired consciousness. He was treated at a local hospital and diagnosed with "cardiogenic syncope, arrhythmia, atrial fibrillation, and cerebral infarction" after completing relevant examinations. His symptoms were relieved after radiofrequency ablation and other treatments. Half a year ago, the above symptoms recurred after fatigue, and he was hospitalized for treatment several times and diagnosed with "chronic heart failure". He took "spironolactone tablets, furosemide, metoprolol sustained-release tablets, enalapril tablets, and henggliflozin tablets" regularly, but his condition was not well controlled. Ten days before admission, the patient had the above symptoms recurred and worsened with fear of cold without obvious causes.

[0069] TCM four-diagnosis: pale complexion, listlessness, shortness of breath, cold body and limbs, sore waist and knees, pale purple lips and nails, clear and long urine, fat tongue, pale purple tongue, deep pulse. Physical examination: medium build, no congestion in the pharynx, no positive signs in the heart and lungs, flat and soft abdomen, no tenderness or rebound pain. Mild edema in both lower limbs.

[0070] Auxiliary examination: NT-proBNP at admission: 9210.4ng / L, heart EF value: 44%, NYHA heart function classification: III, 6-minute walking test (meters): 432 meters, Minnesota scale (points): 76 points. After admission, Huiyang Jiuxin Decoction was given for treatment. After discharge, Huiyang Jiuxin Decoction was continued for consolidation treatment, with a course of 28 days.

[0071] The Huiyang Jiuxin Decoction prepared in Example 2 was taken orally three times in the morning, noon and evening, 100 ml each time, and taken warm after meals. During the medication period, spicy and cold foods should be avoided, wind and cold should be avoided, emotions should be adjusted, and daily life should be cautious.

[0072] Treatment effect: After taking the medicine for 28 days, the patient's symptoms of wheezing and shortness of breath improved. Four examinations: ruddy complexion, fat tongue, pale purple tongue, thin pulse. Re-examination auxiliary examination: NT-proBNP: 763.2ng / L, heart EF value: 57%, NYHA heart function classification: II, 6-minute walking test (meters): 676 meters, Minnesota scale (points): 54 points.

[0073] (3) On July 24, 2023, the inpatient Zhang, female, 64 years old, complained of shortness of breath and fatigue after activities for more than one month. Medical history summary: One month before admission, she developed shortness of breath, fatigue, cough, palpitations and chest tightness after activities, but no chills or fever, nausea or vomiting. She completed electrocardiogram and other examinations at the local hospital, which showed abnormalities. The shortness of breath and breath gradually worsened, and she was unable to lie flat, accompanied by profuse sweating. She went to Chongqing Longhu Hospital for a cardiac ultrasound, which showed: enlargement of both atria and left ventricle, and reduced ejection fraction (ENF 36%). She was considered to have "dilated cardiomyopathy". After taking oral medication (specific details unknown), there was no significant improvement, so she was admitted to Chongqing Longhu Hospital. He was admitted to Xinqiao Hospital and completed cardiac MRI, cardiac ultrasound, dynamic electrocardiogram and other examinations. He was diagnosed with dilated cardiomyopathy and given diuretics, inhibition of ventricular remodeling, and improvement of cardiac function. His symptoms improved and he was discharged. After discharge, he took the following oral medications: furosemide tablets 20 mg once a day, spironolactone tablets 20 mg once a day, empagliflozin 10 mg once a day, sacubitril valsartan sodium 50 mg twice a day, and metoprolol succinate sustained-release tablets 23.75 mg once a day. He still had wheezing, fatigue and weakness.

[0074] TCM four-diagnosis: dark complexion, shortness of breath, bluish lips and nails. Dark purple tongue, tortuous veins at the base of the tongue, ecchymosis, deep and sluggish pulse. Physical examination: medium build, no congestion in the pharynx, no positive signs in the heart and lungs, flat and soft abdomen, no tenderness or rebound pain. No obvious edema in both lower limbs.

[0075] Auxiliary examination: NT-proBNP at admission: 10463.5ng / L, heart EF value: 41%, NYHA heart function classification: Class III, 6-minute walking test (meters): 350 meters, Minnesota scale (points): 76 points. After admission, he was treated with Huiyang Jiuxin Decoction. After discharge, he continued to be treated with Huiyang Jiuxin Decoction for consolidation, and the course of treatment was 28 days.

[0076] The Huiyang Jiuxin Decoction prepared in Example 3 was taken orally three times in the morning, noon and evening, 100 ml each time, and taken warm after meals. During the medication period, spicy and cold foods should be avoided, wind and cold should be avoided, emotions should be adjusted, and daily life should be cautious.

[0077] Treatment effect: After taking the medicine for 28 days, the patient's symptoms of wheezing and shortness of breath improved. Four examinations: pale complexion, pale purple tongue, deep and sluggish pulse. Re-examination of auxiliary examinations: NT-proBNP: 1024.2ng / L, heart EF value: 49%, NYHA heart function classification: II, 6-minute walking test (meters): 519 meters, Minnesota scale (points): 68 points.

[0078] (4) On December 12, 2023, Mr. Li, a 86-year-old male patient, was hospitalized. His chief complaint was shortness of breath and fatigue after activity for more than a year, which worsened with edema in both lower limbs for 4 days.

[0079] Medical history summary: One year before admission, the patient felt shortness of breath, fatigue, and palpitations after activities without obvious triggering factors. He was treated at the Sixth People's Hospital of Nan'an District. After completing relevant examinations, chronic heart failure, coronary atherosclerotic heart disease, and valvular heart disease were considered. After treatment, the symptoms improved, and he took regular medications for secondary prevention of coronary heart disease and heart failure after discharge. Four days ago, the above symptoms worsened and accompanied by edema of both lower limbs. Furosemide was taken for diuretic treatment, but the symptoms did not improve significantly. Four TCM examinations: pale complexion, shortness of breath, fear of cold, cold limbs, and difficulty urinating. The tongue is fat, the tongue is dark purple, and the pulse is deep and moist. Physical examination: fat body, no congestion in the pharynx, no positive signs in the heart and lungs, flat and soft abdomen, no tenderness or rebound pain. Moderate edema of both lower limbs.

[0080] Auxiliary examination: NT-proBNP at admission: 11763.5ng / L, heart EF value: 39%, NYHA heart function classification: Class III, 6-minute walking test (meters): 324 meters, Minnesota scale (points): 75 points. After admission, Huiyang Jiuxin Decoction was given for treatment. After discharge, Huiyang Jiuxin Decoction was continued for consolidation treatment, with a total course of 28 days.

[0081] The Huiyang Jiuxin Decoction prepared in Example 4 was taken orally three times in the morning, noon and evening, 100 ml each time, and taken warm after meals. During the medication period, spicy and cold foods should be avoided, wind and cold should be avoided, emotions should be adjusted, and daily life should be cautious.

[0082] Treatment effect: After taking the medicine for 28 days, the patient's symptoms of wheezing, shortness of breath, and edema of both lower limbs improved. Four examinations: pale complexion, fat tongue, dark purple tongue, and soft pulse. Re-examination auxiliary examinations: NT-proBNP: 1012.4ng / L, heart EF value: 46%, NYHA heart function classification: II, 6-minute walking test (meters): 502 meters, Minnesota scale (points): 67 points.

[0083] In summary, the Chinese medicine composition of the present invention and the Huiyang Jiuxin Decoction prepared using the same have the effects of warming and promoting the flow of heart yang, promoting blood circulation and promoting diuresis, can improve cardiac function, reduce NT-proBNP, increase cardiac function test indicators such as cardiac ejection fraction and improve the quality of life of patients, and are safe, effective and have few side effects.

[0084] Although the embodiments of the present invention have been shown and described above, it is to be understood that the above embodiments are exemplary and are not to be construed as limitations of the present invention. A person skilled in the art may change, modify, replace and vary the above embodiments within the scope of the present invention.

Claims

1. A Chinese medicine composition for treating chronic heart failure, characterized in that: The Chinese medicine composition comprises the following raw materials: cooked aconite root, dried ginger, roasted liquorice root, ginseng, cornus officinalis, cassia twig, tuckahoe, atractylodes macrocephala, salvia miltiorrhiza and agarwood.

2. A Chinese medicine composition for treating chronic heart failure according to claim 1, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 8 to 20 parts of cooked aconite root, 5 to 20 parts of dried ginger, 4 to 30 parts of roasted licorice root, 5 to 15 parts of ginseng, 5 to 15 parts of cornus officinalis, 5 to 15 parts of cassia twig, 3 to 18 parts of poria, 3 to 18 parts of atractylodes macrocephala, 3 to 30 parts of salvia miltiorrhiza, and 1 to 5 parts of agarwood.

3. A Chinese medicine composition for treating chronic heart failure according to claim 2, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 10 to 15 parts of cooked aconite root, 10 to 15 parts of dried ginger, 10 to 15 parts of roasted licorice root, 8 to 12 parts of ginseng, 9 to 12 parts of cornus officinalis, 5 to 12 parts of cassia twig, 6 to 16 parts of poria, 3 to 10 parts of atractylodes macrocephala, 9 to 20 parts of salvia miltiorrhiza, and 2 to 5 parts of agarwood.

4. An application of a Chinese medicine composition for treating chronic heart failure, characterized in that: The Chinese medicine composition according to any one of claims 1 to 3 is used to prepare a medicine for treating chronic heart failure.

5. The use of a Chinese medicine composition for treating chronic heart failure according to claim 4, characterized in that: The dosage form of the medicine includes at least one of decoction, granules, powder, tablets and capsules.

6. The use of a Chinese medicine composition for treating chronic heart failure according to claim 5, characterized in that: The dosage form of the medicine is decoction.

7. The use of a Chinese medicine composition for treating chronic heart failure according to claim 6, characterized in that: The preparation method of the decoction is as follows: weigh cooked aconite root, dried ginger, roasted licorice, ginseng, cornus officinalis, cinnamon twig, poria, atractylodes macrocephala, salvia miltiorrhiza, and agarwood to obtain a mixture, add water and decoct the mixture for 1 to 3 times, filter after decoction, and combine the decoctions obtained each time to obtain Huiyang Jiuxin Decoction in the form of a decoction.

8. The use of a Chinese medicine composition for treating chronic heart failure according to claim 7, characterized in that: The mixture is decocted for 1 to 4 hours.

9. The use of a Chinese medicine composition for treating chronic heart failure according to claim 7, characterized in that: The decoction temperature is 90-110°C.

10. The use of a Chinese medicine composition for treating chronic heart failure according to claim 7, characterized in that: The dosage ratio of the mixture to water is 1:8-12.

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