Suspending aid composition for livestock, preparation method thereof, method for preparing suspension and application of suspending aid composition

Abstract

The invention discloses a suspending agent composition for livestock, a method for preparing a suspension and application of the suspending agent composition. The suspending agent composition for the livestock comprises a suspending agent and optionally one or more of the following components: an auxiliary material, an edible dye and a water softener, the suspending agent is particles with the particle size of 0.1 mm-1mm, or the composition formed by the suspending agent and the optional auxiliary material and / or the edible dye and / or the water softener is particles with the particle size of 0.1 mm-1mm. The preparation method of the suspension comprises the steps that the suspending agent composition is added into water under stirring, stirring continues till the suspending agent in the suspending agent composition is completely hydrated, the suspension with the required viscosity is obtained, a tool with a screen structure is used for stirring, and the ratio of the aperture of the screen structure to the average particle size of the granular suspending agent or the suspending agent composition is (0.3-1): 1. A suspension prepared from the suspending aid composition can be used for suspending coccidian oocyst vaccines, solid medicine particles or feed additives.

Description

Technical Field

[0001] The invention belongs to the field of suspending agents, and in particular relates to a suspension agent composition for poultry and livestock, a preparation method and application thereof. Background Art

[0002] Suspending agents are macromolecular substances that can form a viscous and slippery texture when dissolved in water and fully hydrated under certain conditions. They play the role of thickening and suspending. Suspending agents are used in many industries such as food industry, coatings, biology, pharmaceutical preparations, vaccine immunity, etc. In many occasions in the aquaculture industry, it is usually necessary to use suspending agents on site to prepare suspensions. When preparing suspensions on site, it is hoped that the preparation can be completed in a shorter time to reduce operation time and labor intensity. And the hydration speed of general suspending agent is faster, which causes the extension of final preparation time and the increase of labor intensity, the reason is: the hydration speed of suspending agent is faster, if the suspending agent powder is added to water, the suspending agent powder gathers together very quickly, the suspending agent powder of outer layer contact water is hydrated quickly, the outer layer suspending agent of hydration has larger viscosity, forms a layer of colloid shell, and then hinders water from contacting with internal suspending agent powder, thereby hinders the hydration of internal suspending agent powder, the structure formed is the micelle of external hydration suspending agent wrapping internal unhydrated suspending agent powder, generally this state is referred to as "fish eye" (or "fish eye" shape micelle). And the formation of this "fish eye" shape micelle is greatly affected by operating conditions, and size is difficult to control, once "fish eye" especially "fish eye" of larger size is formed, the slippery state of outer surface, using general stirring rod is difficult to eliminate them by manual stirring. Here it is the reason why the final hydration time is longer. Therefore, to increase the hydration rate, it is necessary to try to avoid the formation of "fish eyes" caused by the secondary distribution of the powder, especially the formation of large "fish eyes". The key is to obtain a dispersion state similar to that of the powder in water, without causing aggregation caused by secondary distribution to form fish eyes. For example, mixing suspending agents with fast hydration rates such as xanthan gum with non-viscous excipients such as glucose, starch, sodium sulfate and other salts and then adding them to water is one of the methods to reduce the formation of "fish eyes". The reason is that a relatively large amount of excipients play the role of dispersing suspending agents such as xanthan gum. When added to water, the dispersion and segmentation of the excipients reduce the possibility of "fish eyes" formed by the secondary distribution of xanthan gum powder; however, for powdered xanthan gum such as 80 mesh and 200 mesh xanthan gum, this secondary distribution effect can be reduced to a certain extent, but due to various reasons such as density and particle size, the secondary distribution of xanthan gum will still cause aggregation and form "fish eyes" when added to water, although this fish eye will be much better than the case without excipients; controlling the addition rate of suspending agent powder is also a common method to reduce the formation of "fish eyes". However, in the field of poultry and livestock farming, it is still hoped that the on-site preparation of the suspension agent can be carried out through extremely simple operations, that is, the suspending agent can be poured into the water relatively quickly (no need to be particularly careful to sprinkle it into the water in small amounts), and no obvious "fish-eye"-like micelles will appear, which can then be quickly hydrated, saving time and reducing labor intensity.

[0003] Suspending agent particles with larger particle size are an important means to reduce the secondary distribution (e.g., aggregation and hydration) of suspending agent when added to water. For example, the millimeter-sized xanthan gum suspending agent composition particles (ZL2022116119392) obtained by mixing and dispersing xanthan gum and molten polyethylene glycol 4000 evenly and then granulating can be directly added to water for hydration (the composition particles have no requirements for the speed of pouring into water), and the rapid hydration process can be completed with the help of a colander, but the preparation process requires melting and cooling, and the cost is relatively high. On the other hand, the proportion of xanthan gum is subject to certain restrictions from the perspective of preparation.

[0004] Xanthan gum is an ideal suspending agent, which is not very sensitive to the hardness of water, has a relatively stable nature, does not have the phenomenon of long drawing after hydration, and can be used to prepare a suspending liquid for water lines. However, the commonly used xanthan gum powder on the market is generally 80 mesh and 200 mesh. Such xanthan gum cannot maintain its dispersed state when added to water due to secondary distribution. It is easy to aggregate to form a structure in which the external hydrated xanthan gum wraps the internal unhydrated xanthan gum, similar to "fish eyes". Moreover, the formation of "fish eye"-like micelles has a certain randomness and varies in size. In particular, it is very difficult to further fully hydrate the larger "fish eye"-like micelles. It is difficult to eliminate such micelles by ordinary manual stirring, making the use of xanthan gum powder very inconvenient. High-speed stirring and dispersing can make the xanthan gum group hydrate quickly and eliminate the group of "fish eyes". However, many breeding sites are generally not equipped with such high-speed dispersing equipment. Usually, the suspension is prepared by manual stirring. Therefore, xanthan gum or similar suspending thickeners will form group of "fish eyes" when added to water. It is very inconvenient to use when preparing suspension in conventional breeding farms; especially when added to water quickly, this disadvantage will be more obvious. Therefore, if the xanthan gum suspending agent or the composition containing the xanthan gum suspending agent is added to water quickly or put into water at one time, and can achieve rapid hydration, then it will be of great significance for the on-site preparation of suspension using the xanthan gum suspending agent. Especially when the suspension is prepared on site manually, the rapid completion of hydration makes it convenient to use and reduces the labor intensity. It is also an important demand for xanthan gum to improve its instant dissolution performance by chemical modification, changing its functional characteristics and solid-state processing performance [Li Jingwei. Production and Application of Microbial Polysaccharide-Xanthan Gum. Beijing: China Agricultural Science and Technology Press, 1995.84]. For example, xanthan gum solution treated with glyoxal can improve the dispersibility and viscosity of the final powder product [Li Jingwei. Production and Application of Microbial Polysaccharide Xanthan Gum. Beijing: China Agricultural Science and Technology Press, 1995.86].

[0005] Therefore, there is a need in the art for a convenient suspending agent or suspending agent composition, which can be added to water quickly or once to quickly obtain a uniform suspension, and will not form "fish-eye" micelles of uncontrollable size due to secondary distribution (aggregation and hydration) of the suspending agent during the addition of water, and the amount used is small. This suspension can be used to achieve coccidia immunization of poultry and livestock or administer other drugs through drinking water. Summary of the invention

[0006] In view of the inconvenience of using suspending agents in the prior art, one aspect of the present invention is to provide a suspending agent composition, which can quickly complete hydration after being added to water, and is very convenient for preparing a suspension for suspension of coccidia oocyst vaccines, solid granular drugs or feed additives. To achieve the purpose of the present invention, the present invention adopts the following technical solutions:

[0007] A suspending agent composition for poultry and livestock, comprising a suspending agent and optionally one or more of the following components:

[0008] A suspending agent, and optionally one or more of the following components:

[0009] Excipients, edible dyes and water softeners,

[0010] The suspending agent is a particle with a particle size of 0.1 mm to 1 mm, or the composition formed by the suspending agent and optional auxiliary materials and / or edible dyes and / or water softeners is a particle with a particle size of 0.1 mm to 1 mm,

[0011] The suspending agent is selected from a short rheological suspending agent, and preferably the short rheological suspending agent is selected from xanthan gum, sodium alginate, potassium alginate, ammonium alginate, carrageenan, guar gum, pectin, sesbania gum, fenugreek gum, papaya seed gum, plantain seed gum, artemisia seed gum, gum arabic, gum ghatti, dextran, welan gum, sodium carboxymethyl cellulose, ammonium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, soluble starch, pregelatinized starch, carboxymethyl starch, polyethylene oxide, or a combination thereof.

[0012] In another preferred embodiment, the suspending agent is selected from modified suspending agents, and the modified suspending agent is xanthan gum modified with aldehyde. In another preferred embodiment, the aldehyde is glyoxal.

[0013] In another preferred embodiment, the auxiliary material is selected from glucose, fructooligosaccharides, manno-oligosaccharides, soluble starch, water-soluble starch, sucrose, maltodextrin, sodium sulfate, potassium sulfate, ammonium sulfate, magnesium sulfate, sodium chloride, potassium chloride, ammonium chloride, magnesium chloride, potassium phosphate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate, sodium phosphate, disodium hydrogen phosphate, sodium dihydrogen phosphate, ammonium phosphate, diammonium hydrogen phosphate, ammonium dihydrogen phosphate, potassium polyphosphate, potassium tripolyphosphate, sodium polyphosphate, sodium tripolyphosphate, ammonium polyphosphate, ammonium tripolyphosphate, polyethylene glycol, or a combination thereof.

[0014] In another preferred embodiment, the dye is selected from brilliant blue, indigo, lemon yellow, carmine, amaranth, carbon black, or a combination thereof.

[0015] In another preferred embodiment, the water softener is selected from imide sulfonates, amino-containing carboxylic acids and their derivatives, hydroxyl-containing carboxylic acids and their derivatives, polyphosphates, or combinations thereof.

[0016] In another preferred embodiment, the amino-containing carboxylic acid and its derivatives are selected from ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetate, sodium nitrilotriacetate, or a combination thereof. In another preferred embodiment, the hydroxyl-containing carboxylic acid and its derivatives are selected from sodium gluconate, sodium citrate, sodium tartrate, sodium carboxymethyl succinate, or a combination thereof.

[0017] In another preferred embodiment, the composition particles formed by the suspending agent and optionally one or more of the auxiliary materials, edible dyes and water softeners are preferably modified suspending agent composition particles, and the modified suspending agent composition particles are aldehyde-modified. In another preferred embodiment, the aldehyde is glyoxal.

[0018] In another preferred embodiment, the xanthan gum composition particles formed by the xanthan gum and optionally one or more of the auxiliary materials, edible dyes and water softeners are preferably modified xanthan gum composition particles. In another preferred embodiment, the modified xanthan gum composition particles are xanthan gum composition particles modified by aldehyde. In another preferred embodiment, the aldehyde is glyoxal.

[0019] In another preferred embodiment, based on the total weight of the suspending agent composition, the weight percentage content of the suspending agent is 20-100%, and the weight percentage content of the auxiliary material is 0-80%.

[0020] In another preferred embodiment, the weight percentage of the suspending agent in the suspending agent composition for poultry and livestock is 30-80%, more preferably 40-70%.

[0021] In another preferred embodiment, the particle size of the granular suspending agent is 0.25 mm to 1 mm, more preferably 0.30 mm to 0.84 mm, or the particle size of the granular composition formed by the suspending agent and optional auxiliary materials and / or edible dyes and / or water softeners is 0.25 mm to 1 mm, more preferably 0.30 mm to 0.84 mm.

[0022] In another more preferred embodiment, the weight percentage of the auxiliary material is 10-70%, more preferably 20-60%.

[0023] In another more preferred embodiment, more than 95% of the total number of the granular suspending agent or the granular suspending agent composition pass through a 18-mesh standard sieve (sieve), and less than 5% of the total number pass through an 80-mesh standard sieve (sieve).

[0024] In another more preferred embodiment, more than 95% of the total number of the granular suspending agent or the granular suspending agent composition pass through a 20-mesh standard sieve, and less than 5% of the total number pass through a 60-mesh standard sieve.

[0025] In another more preferred embodiment, more than 95% of the total number of the granular suspending agent or the granular suspending agent composition pass through a 25-mesh standard sieve, and less than 5% of the total number pass through a 45-mesh standard sieve.

[0026] In another more preferred embodiment, the poultry and livestock suspending agent composition provided by the present invention comprises xanthan gum or modified xanthan gum, and auxiliary materials selected from the following:

[0027] One or more of sodium sulfate, potassium sulfate, ammonium sulfate, magnesium sulfate, sodium chloride, potassium chloride, ammonium chloride, magnesium chloride, potassium phosphate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate, sodium phosphate, disodium hydrogen phosphate, sodium dihydrogen phosphate, ammonium phosphate, diammonium hydrogen phosphate, ammonium dihydrogen phosphate, potassium polyphosphate, potassium tripolyphosphate, sodium polyphosphate, sodium tripolyphosphate, ammonium polyphosphate, and ammonium tripolyphosphate,

[0028] The mass ratio of xanthan gum or modified xanthan gum to the auxiliary material is 1:0.2-4, and

[0029] The xanthan gum or modified xanthan gum is in the form of particles with a particle size of 0.1 mm to 1 mm, or the composition formed by the xanthan gum or modified xanthan gum and the auxiliary materials is in the form of particles with a particle size of 0.1 mm to 1 mm.

[0030] In another preferred embodiment, the poultry and livestock suspension composition comprises the suspending agent, the auxiliary material and the edible dye, wherein the edible dye is added in an amount such that the suspension prepared using the suspending agent composition has a distinct color to attract the attention of poultry and livestock. In another preferred embodiment, based on the total weight of the suspending agent composition, the weight percentage of the edible dye in the poultry and livestock suspension composition is 0.1-1%.

[0031] In another preferred embodiment, the poultry and livestock suspending agent composition comprises the suspending agent, the auxiliary material and the water softener, wherein the water softener is added in an amount according to the hardness of the water, and the amount added is such that the hardness of the water is adjusted to less than 450 mg / L (calculated as CaCO3, GB5749-2022). In some preferred specific embodiments of the present invention, the weight percentage of the water softener in the suspending agent composition is 0.1-10%, preferably 1-5%, based on the total weight of the suspending agent composition.

[0032] In another preferred example, the poultry and livestock suspending agent composition comprises the suspending agent, the auxiliary material, the edible dye and the water softener.

[0033] The present invention also provides a method for preparing the above-mentioned suspending agent composition for poultry and livestock, comprising the steps of: providing a suspending agent, and optionally mixing the suspending agent with auxiliary materials and / or edible dyes and / or water softeners, wherein the suspending agent is particles with a particle size of 0.1 mm to 1 mm.

[0034] In another preferred embodiment of the present invention, the present invention also provides a method for preparing the above-mentioned suspending agent composition for poultry and livestock, comprising the steps of: providing a suspending agent, and optionally mixing the suspending agent with auxiliary materials and / or edible dyes and / or water softeners to prepare particles with a particle size of 0.1 mm to 1 mm.

[0035] The present invention also provides a method for preparing a suspension for poultry and livestock, the method comprising the steps of: adding the above-mentioned suspending agent composition to water under stirring, and continuing to stir until the suspending agent therein is completely hydrated to obtain a suspension of desired viscosity, preferably, stirring using a tool with a sieve structure, the ratio of the aperture of the sieve structure to the average particle size of the granular suspending agent or the suspending agent composition is 0.3 to 1:1.

[0036] In another preferred embodiment, the tool with the screen structure is a colander.

[0037] The present invention also provides the use of the poultry and livestock suspending agent composition in preparing a suspension for suspending coccidia oocyst vaccines, solid medicine particles or feed additives.

[0038] The present invention also provides a method for preparing a suspension for suspending coccidia oocyst vaccine, solid granular medicine or feed additive using the poultry and livestock suspending agent composition, comprising the following steps:

[0039] (1) adding the suspending agent composition to water under stirring, and continuing to stir until the suspending agent is completely hydrated to obtain a suspension of desired viscosity, and

[0040] (2) adding the coccidia oocyst vaccine, solid granular medicine or feed additive into the suspension and uniformly dispersing the suspension therein.

[0041] In another preferred embodiment, the method for preparing a suspension for suspending coccidia oocyst vaccine, solid granular medicine or feed additive using the poultry and livestock suspending agent composition comprises the following steps:

[0042] (1) adding the coccidia oocyst vaccine, solid granular medicine or feed additive into water,

[0043] (2) adding the suspending agent composition to the water containing the coccidial oocyst vaccine, solid granular drug or feed additive obtained in step (1) under stirring, and continuing to stir until the suspending agent is completely hydrated to obtain a suspension in which the coccidial oocyst vaccine, solid granular drug or feed additive is evenly dispersed,

[0044] In another preferred embodiment, a tool having a mesh structure is used for stirring during the preparation of the suspension, and the ratio of the aperture of the mesh structure to the average particle size of the granular suspending agent or the suspending agent composition is 0.3 to 1:1.

[0045] In another preferred embodiment, the coccidia oocyst vaccine is selected from chicken coccidia oocyst vaccine, rabbit coccidia oocyst vaccine, pigeon coccidia oocyst vaccine, duck coccidia oocyst vaccine, goose coccidia oocyst vaccine, pig coccidia oocyst vaccine, cattle coccidia oocyst vaccine, sheep coccidia oocyst vaccine, dog coccidia oocyst vaccine, cat coccidia oocyst vaccine, and guinea pig coccidia oocyst vaccine.

[0046] In another preferred embodiment, the solid particle drug is selected from a drug suspension.

[0047] In another preferred embodiment, the drug suspension is selected from albendazole suspension and toltrazuril suspension.

[0048] In another preferred embodiment, the feed additive is selected from vitamins, amino acids, trace elements, probiotics or a combination thereof required by poultry and livestock.

[0049] That is, the coccidia oocyst vaccine, drug or additive can be added to the water before the suspending agent composition is added to the water, can also be added to the water at the same time as the suspending agent composition is added to the water, or can be added to the water after the suspending agent particles are added to the water. BRIEF DESCRIPTION OF THE DRAWINGS

[0050] Figure 1-1 Shown is a microscope photograph of the xanthan gum particles of Example 1 (magnification 10*4 times).

[0051] Figure 1-2 Shown is a photograph of the xanthan gum particles of Example 1 when they are hydrated (the dispersed state of the particles can be seen).

[0052] Figure 2-1 Shown is a microscope photograph (magnification 10*4 times) of the composition formed by mixing the xanthan gum particles and auxiliary materials in Example 3.

[0053] Figure 2-2 Shown is a photograph of the xanthan gum granule composition of Example 3 when it is hydrated (the dispersed state of the granules can be seen).

[0054] Figure 3 Shown is a microscope photograph of untreated powdered 80 mesh xanthan gum (magnification 10*4 times).

[0055] Figure 4 Shown is a photograph of untreated powdered xanthan gum from Comparative Example 1 quickly poured into water ("fish-eye"-like micelles of varying sizes).

[0056] Figure 5 A tool having a screen structure is a specific embodiment. DETAILED DESCRIPTION

[0057] The inventor of the present application found that although the xanthan gum composition particles (e.g., CN 116059331A) previously developed can eliminate the phenomenon of secondary distribution (hydration after aggregation) of powdered xanthan gum when added to water to form "fish eye" shaped micelles, it can obtain good operating performance and on-site rapid preparation of suspensions. In particular, when a tool (device) with a screen structure is used as an auxiliary material stirring tool, the suspension can be quickly prepared on-site, and the aperture of the screen of the tool with the screen structure and the specific combination of the xanthan gum composition microcapsule particles make the preparation process of the suspension have the visual feature of judging whether the hydration is complete on-site. However, the preparation process of the suspension composition particles is slightly complicated. In addition, the suspension composition particles prepared can undergo a process of melting and recondensation at high temperature, and multiple small particles merge together to become large blocks. Although this generally does not affect the viscosity after the final hydration, the presence of large blocks of the suspending agent composition affects the hydration speed of the suspending agent, making the advantage of the rapid hydration of the suspending agent composition disappear; on the other hand, due to the preparation method, the proportion of the suspending agent is not particularly high, and the amount of the suspending agent used is still slightly large; this increases the cost of storage, transportation, etc. Therefore, further improvements are still needed.

[0058] According to the long-term research on suspending agents, the inventors found that in order to accelerate the hydration rate of the overall suspending agent or its composition, it is necessary to first slow down the hydration rate of the single suspending agent powder. For this reason, the present invention uses a suspending agent with a larger particle size or a surface-treated / modified suspending agent, such as xanthan gum treated / modified with glyoxal (the hydroxyl groups on the surface of the modified xanthan gum are converted into acetals. After adding it to water, it is necessary to first open the acetals to expose the hydroxyl groups before hydration can be carried out), so as to achieve the purpose of rapid hydration. And according to the main contradiction of the fast and slow hydration rate of the suspending agent: the formation of "fish eye" shaped micelles is the main reason for the slow hydration rate of the suspending agent or its composition, and the formation of "fish eye" shaped micelles is caused by the excessively fast hydration rate of the suspending agent and the aggregation and hydration of the suspending agent powders, so as long as the formation of "fish eye" shaped micelles can be eliminated or limited, the final hydration rate can be improved.

[0059] When the proportion of suspending agent in the composition disclosed in the prior art (such as CN202211593890.2) is high, a large number of "fish eye"-shaped micelles of different sizes are easily formed in the process of preparing the suspension, resulting in a very slow hydration rate. The inventor of the present application found that xanthan gum or its composition is made into particles with a diameter of 0.1mm to 1mm. Even if 100% of such xanthan gum particles are used to prepare the suspension, the secondary distribution (aggregation and hydration) of the suspending agent will not form uncontrollable "fish eye"-shaped micelles. At the same time, the hydration rate is very fast when stirring with a tool with a screen structure, which is particularly suitable for rapid preparation of the suspension on site, greatly reducing labor intensity and labor time, and improving efficiency. Moreover, compared with the xanthan gum particle composition with polyethylene glycol as an auxiliary material, the preparation process of the composition containing xanthan gum particles is simpler, and the prepared particles will not have the phenomenon of high-temperature secondary melting. On this basis, after a series of experiments, the present invention was completed.

[0060] In the description of the present invention, when "optionally" is used to describe a component of a composition, it means that the composition may or may not contain the component; when it is used to describe a step in a preparation method or a suspension preparation method, it means that the preparation method or the suspension preparation method may or may not include the step.

[0061] In the description of the present invention, "secondary distribution" means that the suspending agent is re-aggregated after the composition is added into water, relative to the suspending agent which is evenly dispersed by the auxiliary materials in the composition.

[0062] In the description of the present invention, "granular" refers to spherical or quasi-spherical shapes and non-spherical shapes. The general particle size refers to 0.1 mm to 1 mm.

[0063] In the description of the present invention, "suspension" refers to a liquid having a certain viscosity satisfying specific suspension properties obtained after the suspending agent is added to water and hydrated.

[0064] In the description of the present invention, "plurality" means two or more.

[0065] In the description of the present invention, "manual stirring" or "manual slow stirring" or "manual stirring" refers to stirring at 5 to 100 rpm, and further refers to stirring at 30 to 60 rpm, which can generally be achieved by manual stirring using a stirring device.

[0066] In the description of the present invention, "room temperature" or "normal temperature" are the same, both referring to 4 to 40°C.

[0067] In the poultry and livestock suspension agent composition of the present invention, the amount of the auxiliary material has little effect on the hydration of the suspension agent components, so the proportion of the suspension agent can be 1-100%, and the weight percentage of the auxiliary material can be 0-99%, that is, the auxiliary material can be completely omitted. Although it is generally advantageous to use auxiliary materials for general granular suspension agents, the effect of promoting the hydration of the suspension agent components that can be displayed by excessive proportion of auxiliary materials is no longer obvious. Therefore, the poultry and livestock suspension agent composition of the present invention may not contain auxiliary materials, food dyes or water softeners, and is only composed of suspension agents, wherein the suspension agent is granular, and its particle size is 0.1mm-1mm. The poultry and livestock suspending agent composition of the present invention may also contain a suspending agent and an auxiliary material and / or an edible dye and / or a water softener. In this case, the suspending agent composition can be prepared by mixing a granular suspending agent with a particle size of 0.1 mm to 1 mm with conventional auxiliary materials and / or edible dyes and / or water softeners, or by uniformly mixing a conventional suspending agent (non-granular suspending agent) with conventional auxiliary materials and / or edible dyes and / or water softeners to prepare granules with a particle size of 0.1 mm to 1 mm. The granulation process may include condensation, cooling, heating and drying, solvent removal and the like.

[0068] For the sake of convenience and low cost, the weight content of the suspending agent in the suspending agent composition of the present invention is preferably 20-100%, more preferably 30-100%, further preferably 40-100%, such as 100%, 20-80%, 30-80%, 40-70%. Relatively high particle suspending agents are advantageous, which is different from general suspending agent compositions, and the use of 100% suspending agent is difficult to be conveniently used before.

[0069] After the poultry and livestock suspending agent composition of the present invention is added into water, the granular suspending agent or the granular suspending agent composition quickly disperses in the water without agglomerating to form "fish-eye" shaped micelles of uncontrollable size, especially larger ones.

[0070] The suspending agent that can be used in the present invention is preferably a short rheology type suspending agent, so that it can be suitable for waterline operation, while the long rheology type is easy to cause wire drawing and block the water nozzle, affecting the use. In order to make the suspending agent convenient for the actual use status of the livestock and poultry farming industry, for example, to meet the use of livestock and poultry vaccine immunization, the suspending agent is preferably a suspending agent that can be hydrated at room temperature. Suspending agents that require high temperature to obtain viscosity are inconvenient to use in practical applications. Therefore, they are not suitable for the actual scenes of the livestock and poultry farming industry, and many coccidia oocyst vaccines, solid granular drugs or additives that need to be suspended are not resistant to high temperatures. When heating is required to prepare a suspension, the prepared suspension needs to be cooled before use, which also causes inconvenience to use and prolongs the on-site operation time.

[0071] Suspending agents that can be used in the present invention include but are not limited to xanthan gum, sodium alginate, potassium alginate, ammonium alginate, carrageenan, tara gum, guar gum, pectin, sesbania gum, papaya seed gum, plantain seed gum, artemisia seed gum, gum arabic, gum ghatti, dextran, welan gum, sodium carboxymethyl cellulose, ammonium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, soluble starch, pregelatinized starch, carboxymethyl starch and polyethylene oxide.

[0072] In the present invention, the suspending agent is more preferably xanthan gum, guar gum, pectin, sodium carboxymethyl cellulose, and ammonium carboxymethyl cellulose.

[0073] The suspending agent of the present invention is most preferably xanthan gum, and further preferably the xanthan gum is a modified xanthan gum, for example, an aldehyde-modified xanthan gum with an acetal structure, or a xanthan gum modified by octyl trimethoxysiloxane. Such as Calgon's Keltrol CGF-200 mesh xanthan gum (opaque, rapidly hydrated), Keltrol CG TF xanthan gum (fine mesh, transparent and rapidly hydrated), such as Keltrol CG RD xanthan gum (granular, transparent), Keltrol CG GM xanthan gum (granular, low dust); Meihua MHF-40 xanthan gum (granular, low dust), etc. Or use the suspending agent and the auxiliary materials to mix and granulate and then perform surface treatment. For xanthan gum, the modification is preferably aldehyde-modified, and the aldehyde is preferably glyoxal.

[0074] Preparation of suspending agent solution generally requires the use of water, the simplest being to use tap water, or directly use underground water (such as well water, spring water, etc.). However, the water quality of different regions is very different, for example, the hardness of mountain water is relatively large, even if the hardness of tap water also can have relatively large difference, not to mention the underground water without special treatment. Therefore, the suspending agent in the present invention is preferably a suspending agent of unknown sense of hardness of water, for example, xanthan gum, guar gum, pectin, sesbania gum, fenugreek gum, papaya seed gum, plantain seed gum, wormwood seed gum, arabic gum, ghatti gum, dextran, welan gum, sodium carboxymethylcellulose, ammonium carboxymethylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, soluble starch, pregelatinized starch, carboxymethyl starch, polyethylene oxide.

[0075] The present invention does not have high requirements for auxiliary materials. The auxiliary materials are preferably varieties with good water solubility, and generally varieties with low viscosity after hydration are selected. The auxiliary materials used in the present invention preferably do not produce obvious viscosity in the suspension, and the main component that produces viscosity and suspension function is the suspending agent. In other words, the viscosity of the suspension is mainly contributed by the suspending agent. For example, more than 90% of the viscosity of the suspension is contributed by the suspending agent. For example, under the same quality conditions, the suspending agent component and the auxiliary materials in the suspending agent composition used in the present invention produce a viscosity that is at least three times that of the latter. Further preferred auxiliary materials are glucose, fructooligosaccharides, manno-oligosaccharides, soluble starch, water-soluble starch, sucrose, maltodextrin, sodium sulfate, potassium sulfate, magnesium sulfate, sodium chloride, and potassium chloride.

[0076] It is generally advantageous to add edible dyes and / or pigments to the composition of the present invention. In addition, dyes are advantageous because preliminary uniformity can be determined by dyeing in actual use.

[0077] In the present invention, the weight content of the dye in the suspending agent composition is preferably 0.1-1%. Further preferably, it is 0.1-0.5%. The dye is used as an indicator, so its amount is less. Generally, the amount of 0.1-1% is enough to obtain the effect of the color indication. For example, brilliant blue has very strong dyeing performance, and a very small amount can obtain a very obvious color. The dye that can be used in the present invention includes but is not limited to brilliant blue, indigo, lemon yellow, carmine, and amaranth. The tinting power of brilliant blue is relatively strong, and a combination of brilliant blue, lemon yellow, and carmine is preferred.

[0078] When no special dye is added, the opaque white color of the granular suspending agent and / or the suspending agent composition itself can also be used as a visual feature as a basis for hydration judgment.

[0079] In order to obtain a suspending agent composition that is less affected by water quality, it is necessary to add a component (for example, a water softener) that reduces the sensitivity of the suspending agent to water quality in the suspending agent composition. The water quality mentioned here mainly refers to the different hardness of water caused by calcium and magnesium ions. The principle that the water softener reduces the sensitivity of the suspending agent to water quality is that it has a higher priority than the suspending agent in complexing calcium and magnesium ions, so that the viscosity change of the suspension prepared by the water quality is reduced. The water softener that can be used for the present invention includes but is not limited to imide sulfonates, amino-containing carboxylic acids and derivatives thereof (for example, ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetate, sodium nitrilotriacetate, etc.), hydroxy-containing carboxylic acids and derivatives thereof (for example, sodium gluconate, sodium citrate, sodium tartrate, sodium carboxymethyl succinate, etc.), and polyphosphates. Although water softeners are advantageous for most suspending agents, they are insensitive to water quality for xanthan gum, etc., and it is preferred not to add the substance.

[0080] The suspending agent composition of the present invention preferably uses a suspending agent that is insensitive to the hardness of water (such as xanthan gum).

[0081] For xanthan gum, adding a small amount of salt is useful to further reduce the impact on water quality. This effect can be achieved using general salt substances, such as potassium chloride, sodium chloride, etc.

[0082] When the suspending agent composition of the present invention contains auxiliary materials and / or dyes and / or water softeners, the auxiliary materials and / or dyes and / or water softeners can be mixed with granular suspending agents (that is, the suspending agent itself is prepared into granules in advance), or the auxiliary materials and / or dyes and / or water softeners can be mixed with non-granular suspending agents, and after uniform mixing, they are prepared into granules together. Granulation can be achieved by centrifugal granulation, spray granulation or extrusion, or by crushing and screening the dried raw materials.

[0083] The process of preparing a granular suspending agent composition by uniformly mixing the suspending agent with the auxiliary material and / or the dye and / or the water softener generally includes using a solvent to uniformly mix these components, grinding, and then drying to remove the solvent to obtain a large solid. The large solid is crushed to obtain a granular suspending agent composition.

[0084] The obtained granular suspending agent composition can be further surface treated / modified (for example, surface treated with glyoxal) so that the surface of the suspending agent has an acetal structure.

[0085] The method for preparing a suspension using the suspending agent composition of the present invention is to add the suspending agent composition to water under stirring, and continue stirring until the suspending agent therein is completely hydrated to obtain a suspension of the desired viscosity. Stirring preferably uses a tool with a screen structure, and the ratio of the aperture of the screen structure to the average particle size of the granular suspending agent or suspending agent composition particles is 0.3 to 1: 1. When the suspending agent used is a surface-treated suspending agent (such as surface-treated with glyoxal), even if the particle size of the granular suspending agent or suspending agent composition particles is small (for example, 80 mesh), it will not form a large amount of "fish eye"-like micelles when added to water, and the tool with a screen structure can be used for stirring in the process of preparing the suspension. When the particle size of the granular suspending agent or suspending agent composition particles is large, such as when the particle size is greater than 80 mesh, the tool with a screen structure is generally required to stir in the process of preparing the suspension. In actual use, the aperture of the screen is generally preferably larger than 60 mesh; generally 50 mesh and 40 mesh can meet most requirements, the maximum aperture does not exceed 12 mesh (ie 1.70 mm), and the general mesh number is larger than 20 mesh (aperture less than 0.850 mm).

[0086] The stirring of the tool with the screen structure can provide a larger stirring area, and also provides shearing force for the suspending agent particles whose particle size is not greater than its aperture. For the used surface-treated suspending agent with a smaller particle size (for example, the particle size of the glyoxal surface-treated xanthan gum is 80 meshes, which is smaller), in the process of preparing the suspension, the stirring of the tool with the screen structure mainly provides a larger stirring area (the aperture of the screen can be significantly greater than the particle size of the suspending agent), because such suspending agent itself is well dispersed in water, has a small particle size, and a fast hydration speed, and does not require additional shearing force to promote its hydration.

[0087] The tool with the screen structure can be a stirring device for rapidly hydrating the suspending agent disclosed in the prior art CN220425174U, or can be a colander or strainer with round holes on the head similar to those used in daily life. Figure 5 A tool having a mesh structure, also referred to as a mesh colander, that can be used in the present invention is shown.

[0088] The wire or line of the woven screen structure can be metal or plastic material, preferably with greater strength, sufficient to prevent the concave surface from flipping during stirring. The diameter of the wire or line (wire diameter, wire diameter) is preferably less than 2 mm, more preferably less than 1 mm, and more preferably less than 0.6 mm, for example 0.4-0.03 mm. To maintain a certain strength, preferably 0.4-0.1 mm, 0.4 mm, 0.3 mm, 0.25 mm, 0.2 mm, 0.15 mm, 0.1 mm. The wire diameter of the commonly used mesh screen is preferred. The materials of common industrial or civilian screens can be applied to the present invention. The diameter of the wire or line that generally makes up the screen is smaller than or much smaller than the size of the hole formed.

[0089] The method for preparing a suspension using the suspending agent composition of the present invention is very simple and can meet the general operation requirements of aquaculture farms. A specified amount of the suspending agent composition is added to water and stirred to hydrate the suspending agent. If a colander is used for stirring, the degree of hydration can be judged by observing the changes in the "fish eye"-shaped micelles on the colander.

[0090] Although the suspending agent composition of the present invention is preferably added to the water slowly and stirred while being added to the water, the suspending agent composition of the present invention has very low requirements for the speed of adding to the water, and the suspending agent can even be added at one time. When added to the water at one time, it is preferably stirred during the addition process, and the stirring is continued for 1 to 2 minutes after the addition is completed, so that the granular suspending agent or its composition can be avoided to form a large number of "fish eye"-shaped micelles after hydration, resulting in the extension of the subsequent hydration time. Although stirring all the time can quickly obtain rapid hydration, after the suspending agent composition is added, it is not necessary to stir all the time. The hydration obtained by stirring for 1-5 minutes in the early stage can generally meet the purpose of suspending its own granular suspending agent, and then it can be left to stand, allowing it to suspend and hydrate, and then stirred again, especially using a colander to stir for better effect and faster speed. That is to say, after the suspending agent composition is added to the water, the stirring system needs to be stirred at the beginning, and then it can be left to stand, without stirring all the time, or it can be stirred from time to time, for example, stirring once every 5-10 minutes, stirring for 1-2 minutes at a time, and stirring 1-2 times can make the suspending agent completely hydrated.

[0091] The suspending agent composition of the present invention can be directly and quickly added to water for use when in use, and does not need to be carefully poured slowly or sprinkled into water by a porous device, thereby solving the "fish eye" problem that is difficult to be eliminated by manual stirring when a powdered suspending agent or its composition is added to water. In addition, when the suspending agent composition of the present invention is added to water, because of its own particle characteristics, or the particle characteristics of the suspending agent therein, particularly the granular surface-treated / modified suspending agent or its composition (which has the characteristics of delayed hydration), it can be dispersed in water in water in the original particle state relatively uniformly, and each particle is relatively independent of each other. When the suspending agent composition is added to water like this, it can be added quickly without worrying about the adhesion between particles, and after being added to water, stirring can relatively independently complete the hydration of each other, and a large amount of "fish eye"-shaped micelles of uncontrollable size will not be formed because of the aggregation hydration.

[0092] When utilizing the suspending agent composition of the present invention to prepare suspension, when using a tool with a screen structure to stir, a single granular suspending agent or suspending agent composition can be stirred with a greater probability to obtain faster hydration. And while the tool with the screen structure provides the stirring function, it also provides the function of shearing, so that the hydrated part of the partially hydrated granular suspending agent or suspending agent composition is sheared and separated from the granular suspending agent body, providing a faster hydration rate. That is to say, the suspending agent composition of the present invention itself or the suspending agent used is a particle with a larger particle size, and when added to water, the hydration rate is limited, avoiding the formation of a large amount of "fish eye"-shaped micelles of uncontrollable size due to the suspending agent aggregation hydration. In water, the granular suspending agent or suspending agent composition itself is hydrated to form a small "fish eye"-shaped agglomerate, which is hydrated in the subsequent stirring process, and particularly can be achieved by stirring with a tool with a screen structure. Rapid hydration. Once the suspending agent gathers together to form a large number of "fish-eye" micelles of uncontrollable size, it will take a long time to obtain a fully hydrated suspension, because the larger "fish-eye" micelles are difficult to eliminate, even if stirred. Therefore, the suspending agent composition of the present invention actually obtains the effect of faster overall hydration rate by slowing down the hydration rate of the suspending agent itself.

[0093] When a general powdered suspending agent (such as a product with a general particle size of 80 mesh, and a general 80 mesh pass rate of greater than 95%) is quickly added to water, due to the excessively fast hydration speed, the outermost layer of the agglomerated suspending agent powder is quickly hydrated to form a viscous colloid shell, which prevents the internal suspending agent powder from further contacting water. Once this structure is similar to a "fish eye"-like micelle, only when the outer layer of the viscous colloid shell is diluted by water and gradually separated from the "fish eye" can the internal unhydrated suspending agent powder have the opportunity to contact water and produce hydration. If the powdered suspending agent is quickly added to water and the stirring is not fast enough, the micelle formed will be very large, that is, the "fish eye" will be very large, sometimes even at the centimeter level. In this case, the process of complete hydration is very slow and requires vigorous stirring to achieve. Even if a tool with a screen structure is used, the "fish eye"-like micelle formed will adhere to the screen of the stirring tool, which is not conducive to rapid hydration. Surface treated / modified suspending agents can improve their hydration state, but when finer suspending agent powder is added to water, it is still easy to form large "fish eye" shaped micelles. The suspending agent composition of the present invention uses a granular suspending agent with a larger particle size or a granular suspending agent composition with a larger particle size, and the size of the "fish eye" shaped micelles formed is determined by the shape of the granular suspending agent and / or the granular suspending agent composition itself. For a single granular suspending agent or suspending agent composition dispersed in water, because it has an original morphology, the granular suspending agent or suspending agent composition can not contact each other after being added to water, and each is dispersed in water, and the outer layer of each particle first contacts with water and hydrates. Because the suspending agent is evenly dispersed by the auxiliary material, it can be sheared by the screen of the stirring tool during hydration, accelerating the hydration part to separate from the particle body, and finally completing rapid hydration, so it is particularly suitable for preparing suspension on site in places without electric stirring and dispersing equipment. When the particle size of the granular suspending agent or the suspending agent composition is relatively small, such as about 0.1mm, 0.2mm, etc., under the subsequent stirring action, it is easier to achieve hydration. Although the addition of auxiliary materials is not necessary, it is generally advantageous because the auxiliary materials can improve the uniformity of the dispersion of the suspending agent in water when added to the water, and reduce the probability of forming a larger "fish eye" shape micelle due to the aggregation and hydration of the suspending agent (the larger "fish eye" shape micelle is difficult to eliminate). And when the particle size of the granular suspending agent or the suspending agent composition itself is larger, such as the particle size of 0.5mm, 0.6mm, 0.7mm, 0.8mm, etc., the probability of forming a larger "fish eye" shape micelle due to the aggregation and hydration of the suspending agent in its hydration process is greatly reduced, so the necessity of auxiliary materials further decreases, and it is also possible not to use auxiliary materials at all. In this case, the use of a tool with a screen structure as a stirring tool for the effect of rapid hydration is particularly important.For a granular suspending agent or suspending agent composition with a particle size of 0.5 to 1 mm, if the suspending agent itself is surface treated / modified, for example, by using aldehyde treatment / modification to obtain an acetal structure on its surface to block part of the hydroxyl groups, thereby slowing down hydration, then when added to water, it will not hydrate quickly immediately, and it will be easy to disperse evenly in water when added to water, reducing the probability of the suspending agent agglomerating and hydrating to form larger "fish-eye" micelles. In this case, the importance of excipients is further reduced, and the form of not using excipients can be adopted.

[0094] In the process of preparing the suspension, it is preferred to use a stirring tool with a screen structure for stirring, and when the aperture of the screen structure matches the particle size of the granular suspending agent or the suspending agent composition, not only can the hydration process be further accelerated, but the disappearance process of the "fish eye" accompanying the hydration process can also be more intuitively observed, which is more suitable for on-site preparation of the suspension, especially on-site manual preparation of the suspension.

[0095] The function of the suspending agent in the suspending agent composition is to increase the viscosity of the water when added to water, so that it has a suspension effect. The requirements for suspension can generally be adjusted and selected according to the actual application scenario. In this way, particles such as coccidia oocyst vaccines, solid granular drugs or feed additives are suspended in water. For example, 3 to 50 g of the suspending agent composition of the present invention is added to 1 L of water, and the viscosity of the prepared water suspension medium is 20 to 500 mpas (rotational viscometer, measured using rotor 1 at 6 rpm), which can meet the suspension requirements of conventional coccidia oocyst vaccines, solid granular drugs or feed additives. For conventional coccidia oocyst vaccines, solid granular drugs or feed additives, the density is generally 0.8 to 1.5 g / cm 3 , the water medium with a viscosity of 20mpa.s to 500mpa.s can suspend it for 6 to 12 hours. For general coccidia oocyst vaccines, solid granular drugs or feed additives, 6-8 hours of suspension can meet the actual production requirements. For coccidia oocyst vaccines, solid granular drugs or feed additives with larger density and larger particles, sufficient suspension can be obtained by reducing their particles or appropriately increasing the amount of suspending agent and increasing its viscosity. The amount of suspending agent can be obtained through experiments according to specific needs, and in actual use, it only needs to be prepared according to the required dosage.

[0096] Compared with the prior art, the advantages of the suspending agent composition of the present invention include:

[0097] 1. The suspending agent of the present invention is not easy to aggregate and hydrate when added to water to form larger "fish-eye" shaped micelles, and a faster hydration speed can be obtained.

[0098] 2. Surface treated / modified suspending agents such as xanthan gum can be used alone to prepare suspensions, and they have the characteristics of rapid hydration when used with a colander. 100% of the suspending agents can be prepared quickly on site manually.

[0099] 3. It does not contain low-melting-point substances, and there is no phenomenon of melting at high temperatures and agglomerating after condensation, so the storage application range is wider.

[0100] The present invention will be further described below in conjunction with specific examples. Specific examples are implemented under the premise of technical solutions of the present invention, and detailed implementation methods and operating procedures are provided. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. The experimental methods for which specific conditions are not specified in the following examples are usually carried out under normal conditions. Unless otherwise indicated, ratios and percentages are by weight.

[0101] The viscosity test was conducted at various rotation speeds using a rotational viscometer [NDJ-1 Rotational Viscometer, Shanghai Yueping Scientific Instrument Co., Ltd.].

[0102] The suspending agents used in the following examples, such as xanthan gum, are untreated commercially available xanthan gum unless otherwise specified.

[0103] The colander mentioned in the following examples is as follows Figure 5 shown.

[0104] Example 1

[0105] The suspending agent composition of this embodiment has no other auxiliary materials except granular xanthan gum (brand name MHF-40, manufacturer Meihua Group (20 mesh pass rate> 90%, 200 mesh pass rate< 5%). The microscopic view of granular xanthan gum is Figure 1-1 .

[0106] The particle size of the granular xanthan gum is about 0.25-0.60mm. As can be seen from Figure 1, the xanthan gum particles are relatively large, so when added to water under stirring, the xanthan gum particles can be dispersed faster in water, are not easy to aggregate and hydrate, and form a large number of "fish eye"-shaped micelles of uncontrollable size, and basically maintain the original particles in the water for hydration process. After the granular xanthan gum is added to the water, a 40-mesh (0.425mm aperture) colander is used for stirring, and the xanthan gum is gradually hydrated, and the hydrated part is separated from the particle body by the shear force applied by the colander, exposing new unhydrated and / or insufficiently hydrated parts, and further completing the hydration process under the stirring of the colander.

[0107] 6g of the above xanthan gum particles were added to 6L of water under stirring, and stirred for 3 minutes with a colander (A). The viscosity of the test liquid was 45 (mPa.s at 6rpm). After standing for ten minutes, no obvious sedimentation was observed, but a small amount of small "fish-eye" micelles were suspended in it. After that, the colander was used to stir for 2 minutes (B). Almost no "fish-eye" micelles were observed, and the viscosity of the test liquid was 139 (mPa.s at 6rpm) (see Table 1-1). Stirring was continued, and the viscosity of the test liquid was about 140mPa.s at 6rpm at 2h, indicating that the liquid had basically reached the expected viscosity at time B.

[0108] Table 1-1

[0109] 6rpm 60rpm A time, stirring for 3 minutes 45 19 B time, stirring for 5 minutes, total time 15 minutes 139 41 After stirring for 2h 140 42

[0110] It can be seen that although 100% xanthan gum is used to prepare the suspension, almost complete hydration can be obtained after stirring for a total of 5 minutes. This is because large particles of xanthan gum are not easy to aggregate and hydrate to form larger "fish-eye" micelles. On the other hand, a 40-mesh colander is used, the aperture of which is about 0.425 mm, which matches the particle diameter of 0.25-0.60 mm of the particles of granular xanthan gum. The aperture can exert a certain shear on the xanthan gum, so that the hydrated part of the xanthan gum is separated from the main body of the particle. The particles except the surface hydrated part are easy to separate from the screen mesh, complete the hydration and be sheared by the colander next time. Moreover, the interception amount of the granular xanthan gum by the colander and the change in the interception amount can reflect the degree and speed of hydration, which is convenient for the on-site preparation of the suspension in the farm.

[0111] Chicken coccidia oocyst vaccine was added to the suspension, stirred evenly, and then the viscosity was tested and the oocyst count was performed, and it was found that good suspension performance could be obtained.

[0112] The counting of chicken coccidiosis oocyst vaccine is carried out according to the method of ZL2022116119392. Because the viscosity of this embodiment is higher, it shows better suspension performance. The difference in the number of oocysts in the upper and lower layers for 8 hours is no more than 10%, which can fully meet the requirement of suspending chicken coccidiosis oocyst vaccine for 8 hours. According to the requirements of chicken coccidiosis oocyst vaccine for suspension, the viscosity is generally more than 50mPa.s at 6rpm, which can meet the requirement of suspension for 6 hours (drinking water containing oocyst vaccine is generally required to be drunk within 6 hours).

[0113] Example 2

[0114] The suspending agent composition of the present embodiment only contains the xanthan gum of the brand MHF-40, the manufacturer is Meihua Group (20 mesh pass rate>90%, 200 mesh pass rate<5%), and the product obtained by glyoxal surface treatment. It does not contain other components. The glyoxal surface treatment method is with reference to U.S. Patent 4041234, specifically: 4mL of 2-propanol solution of glyoxal (wherein the consumption of glyoxal is 0.05% of xanthan gum weight) is sprayed on the xanthan gum under low-speed mixing state, and then continue to mix at low speed for 9 minutes, and then the mixture is dried at a temperature of 80 ℃ in a forced ventilation furnace for 1 hour. In this process, the xanthan gum basically maintains the original particle state, and the particle diameter of the xanthan gum does not change much, and is still approximately 0.25-0.60mm.

[0115] Hydration was carried out according to Example 1.

[0116] 6g of the surface-treated xanthan gum was added to 6L of water under stirring. A 40-mesh colander was used to stir for 3 minutes (A). The viscosity of the test liquid was 44 (mPa.s at 6rpm). After standing for ten minutes, no obvious sedimentation was observed in the water, but a small amount of small "fish-eye" micelles were suspended in the water. After that, a colander was used to stir for 2 minutes (B). Almost no "fish-eye" micelles were observed. The viscosity of the test liquid was 140 (mPa.s at 6rpm) (see Table 2-1). Stirring was continued until the viscosity of the test liquid was about 141mPa.s at 6rpm at 2h, indicating that the liquid had basically reached the expected viscosity at time B.

[0117] Table 2-1

[0118] 6rpm 60rpm A time, stirring for 3 minutes 44 18 B time, stirring for 5 minutes, total time 15 minutes 140 40 After stirring for 2h 141 41

[0119] Compared with Example 1, its hydration viscosity at different stirring times is basically close to that at several time points in Example 1, indicating that the xanthan gum particles themselves can be dispersed when the surface-treated xanthan gum in the granular state is added to water, and the effect of the surface treatment on the overall hydration rate of the suspending agent is not obvious. It also shows that for suspending agents with larger particles, a colander can be used to obtain a rapid hydration effect even without surface treatment.

[0120] Example 3

[0121] The suspending agent composition of this embodiment includes surface-treated xanthan gum particles (50 mesh), potassium chloride and glucose, as shown in Table 3-1, wherein the xanthan gum is surface-treated with glyoxal.

[0122] Table 2-1

[0123]

[0124] Wherein xanthan gum treatment is carried out surface treatment with reference to the method of U.S. Patent No. 4041234, specifically: weigh 25 grams of 80 mesh xanthan gum and place it in a mortar, take 8g of commercially available glyoxal solution (original mass concentration is 40%, wherein the amount of glyoxal is 0.1% of the weight of xanthan gum) diluted with water, then spray the glyoxal solution onto the xanthan gum ground while stirring, continue to grind the above-mentioned mixture colloid, 10 minutes. Then the above-mentioned mixture is spread on a dry glass plate, heated to a temperature of 100° C. in a forced ventilation furnace and dried for about 20 minutes. Stir from time to time in the initial 10 minutes to ensure uniform drying. Grind afterwards and screen the intercepted middle part (referred to as 50 mesh) through 50 mesh and 80 mesh screens.

[0125] The preparation process of the suspending agent composition is: uniformly mix the xanthan gum particles treated with glyoxal, potassium chloride and glucose, which can generally be packed in a bag and poured out from the bag when used.

[0126] The method for preparing the suspension is: add 15g of the suspending agent composition to 6L of water, add it all at once (about 1min), and use a stirring rod (straight rod) to stir quickly when adding, and continue stirring for 4 minutes after adding (A). It can be seen that there will be a small amount of "fish-eye"-like micelles when adding, but they can be basically quickly dispersed after stirring with a glass rod. Continue stirring for 2 minutes after an interval of 10 minutes (B), and basically no "fish-eye"-like micelles are observed. The viscosity of the feed liquid is tested, and then stirred for 2 hours. The viscosity of the feed liquid is tested. The results are shown in Table 3-1.

[0127] Table 3-1

[0128]

[0129]

[0130] From the viscosity data in Table 3-1, it can be seen that for the suspending agent composition of this example, hydration can be achieved directly by stirring with a straight stick, and a satisfactory hydration speed can be achieved without a colander.

[0131] Using a 40 mesh colander can achieve hydration faster. The method of preparing the suspension using a colander is as follows:

[0132] 15g of the suspending agent composition was added to 6L of water, added all at once (about 1min), and then stirred with a 40-mesh colander. Due to the large stirring area of ​​the colander, the xanthan gum in the composition can be quickly dispersed in the water without forming a large number of "fish-eye" micelles of uncontrollable size. The small amount of "fish-eye" micelles formed will also be quickly dispersed under the continued stirring of the colander and will not easily hydrate and adhere to the colander. First stir for 2 minutes, then let stand for 3 minutes, and then stir for 2 minutes, and test the viscosity of the liquid. The results are shown in Table 3-2.

[0133] Table 3-2

[0134]

[0135] From the viscosity data in Table 3-2, it can be seen that the use of a colander to stir (provide a larger stirring area) during the preparation of the suspension of xanthan gum surface treated with glyoxal can hydrate the xanthan gum more quickly, shorten the preparation time of the suspension, and make it more suitable for use on-site aquaculture.

[0136] Comparative Example 1

[0137] The suspending agent composition of this comparative example includes xanthan gum (50 mesh), potassium chloride and glucose, as shown in Table 1-1a. The particle size of the xanthan gum is a product that has not been treated with glyoxal, and 80 mesh xanthan gum is ground with water and then dried and crushed, and the middle part (called 50 mesh) is sieved through 50 mesh and 80 mesh sieves.

[0138] Table 1-1 a

[0139] Components Xanthan gum granules (50 mesh) Potassium chloride glucose Weight content 40.0％ 5.0％ 55.5％

[0140] The preparation process of the suspending agent composition is as follows: the xanthan gum, potassium chloride and water-soluble starch are mixed evenly, packed in a bag, and poured out from the bag when in use.

[0141] The method for preparing the suspension is: add 15g of the suspending agent composition to 6L of water, the addition speed is similar to that of Example 3, and the addition is completed in about 1min, and a stirring rod (straight rod) is used to stir quickly during the addition, and a large number of "fish eye"-shaped micelles of uncontrollable size can be seen in the water, and they are difficult to be destroyed by stirring using a stirring rod (straight rod). After the composition is added, continue stirring for 4 minutes (A), test the viscosity of the feed liquid, stop stirring, and let it stand for 10 minutes, and continue stirring for 4 minutes (B), there are still many "fish eye"-shaped micelles, test the viscosity of the feed liquid, and then stir for 2h, test the viscosity of the feed liquid, and the results are shown in Table 1-1b.

[0142] Table 1-1b

[0143]

[0144] From the viscosity data of Table 1-1b, it can be seen that the suspending agent composition of the comparative example has a large number of "fish-eye" micelles of uncontrollable size when poured into water because xanthan gum has a faster hydration rate and a larger proportion, which are difficult to be destroyed during the subsequent stirring process of the stirring rod. Even after 2 hours, there are still some "fish-eye" micelles in the feed liquid that cannot be hydrated, and the viscosity of the feed liquid is significantly lower than that of the feed liquid of Example 3.

[0145] Example 4

[0146] The suspending agent composition of this example is composed of surface-treated xanthan gum particles (80 mesh) and auxiliary materials (as shown in Table 3-1), wherein the auxiliary materials are glucose and sodium polyphosphate, as shown in Table 4-1.

[0147] Table 4-1

[0148]

[0149] The preparation process of the suspending agent composition of this embodiment is as follows: xanthan gum (80 mesh) is treated with glyoxal (the treatment process is the same as that of Example 3, and the amount of glyoxal used is 0.1% of xanthan gum), and then mixed with glucose and sodium polyphosphate until uniformly mixed, and then the powder is packed into bags.

[0150] The method of preparing the suspension by stirring with a straight stick is as follows: 20 g of the suspending agent composition is poured into 6 L of water, and stirred with a straight stick while pouring. A small amount of "fish-eye"-shaped micelles can be seen just after pouring into the water, and they are immediately dispersed after stirring. After stirring for 2 minutes, there are still a small amount of small "fish-eye"-shaped micelles in the liquid. Stirring is continued for 7 minutes, and basically no micelles can be seen. The viscosity of the liquid is tested, and the viscosity is 100 mPas at 6 rpm. Stirring is continued for 2 hours, and the viscosity of the test liquid is about 105 mPa.s, indicating that after stirring for 7 minutes, the xanthan gum particles in the composition have been basically completely hydrated.

[0151] The method of preparing the suspension by stirring with a colander is as follows: 20 g of the suspending agent composition is poured into 6 L of water, and a 40-mesh colander is used to stir while pouring. Just after pouring, a small amount of "fish-eye"-shaped micelles stick to the colander, which can be dispersed immediately after stirring. After stirring for 2 minutes, there are only a small amount of small "fish-eye"-shaped micelles in the feed liquid. Stirring is continued for 6 minutes, and basically no micelles can be seen in the feed liquid. The viscosity of the test feed liquid is about 104 mPas at 6 rpm. Stirring is continued for 2 hours, and the viscosity of the test feed liquid is about 105 mPa.s (at 6 rpm), indicating that the use of a colander can slightly increase the hydration rate of the suspending agent (at this time, the colander mainly provides a larger stirring area and basically does not provide shear force). However, for the suspending agent composition of the present embodiment, the use of a colander to stir the hydration rate of the surface-treated xanthan gum particles is not significantly changed.

[0152] Example 2

[0153] In this comparative example, xanthan gum (80 mesh) is used as a suspending agent and glucose is used as an auxiliary material. The composition of the suspending agent is shown in Table 2-1a.

[0154] Table 2-1a

[0155] Components Xanthan gum (80 mesh) glucose Sodium Polyphosphate Weight content 25％ 70..0％ 5.0％

[0156] Xanthan gum is mixed evenly with glucose and sodium polyphosphate and the powder is packed into bags.

[0157] Add 20g of suspending agent into 6L of water and stir with a straight stick while pouring. It can be seen that a large number of "fish-eye"-shaped micelles of uncontrollable size are formed in the water, and they still cannot be dispersed after stirring. After stirring for 2 minutes, there are still many "fish-eye"-shaped micelles. Continue stirring for 20 minutes, and there are still smaller "fish-eye"-shaped micelles. It can be seen that some "fish-eye"-shaped micelles will float on the liquid surface and are wrapped with bubbles. The viscosity of the feed liquid is tested. The viscosity is 80mpas at 6rpm. Continue stirring for 2h. The viscosity of the feed liquid is tested, which is about 105mPa.s, indicating that the fish eyes cannot be completely eliminated after 20 minutes of stirring and the xanthan gum cannot be completely hydrated.

[0158] Add 20g of the suspending agent composition to 6L of water and pour it in. Figure 5 The mesh colander (40 mesh) shown was used for stirring. Just after pouring, there were many "fish-eye"-like micelles stuck to the colander and could not separate from the colander after stirring. There were also many small uncontrollable "fish-eye"-like micelles in the liquid. After stirring for 2 minutes, there were still many "fish-eye"-like micelles. Stirring was continued for 6 minutes, and there were still "fish-eye"-like micelles stuck to the colander. The viscosity of the liquid was tested, and the viscosity was 70 mPas at 6 rpm. Stirring was continued for 2 hours, and the viscosity of the liquid was tested, which was about 103 mPa.s.

[0159] For this fine particle size unprocessed xanthan gum, use Figure 5 The 40-mesh colander shown does not significantly speed up the hydration process, but rather slightly slows it down. This is because when the xanthan gum is added to the water, it quickly combines with the water in the colander and adheres to the colander, making it even harder for the gelatin mass to hydrate. Figure 5 The mesh colander shown in the figure accelerates the hydration speed of xanthan gum on the premise that the xanthan gum itself can be dispersed in water to maintain its original particle size. Once more xanthan gum gathers together and hydrates to form a large number of "fish-eye" shaped micelles with uncontrollable sizes, use Figure 5 The colander shown does not speed up the hydration effect.

[0160] 20g of the suspending agent composition was added to 6L of water, and a spider web colander was used to stir the mixture during the pouring process (i.e., the head of the colander was in the shape of a spider web, and the gaps between the webs were relatively large, for example, 1mm). Just after pouring into the water, there were a large number of "fish eye"-shaped micelles of uncontrollable size in the water, but because the spiral web of the spider web colander was thicker (generally at the millimeter level) and the intervals were relatively far (generally at the centimeter level), there were no obvious "fish eye"-shaped micelles adhering to the colander. Using the spider web colander to stir can break up the larger "fish eye"-shaped micelles. After stirring for 2 minutes, there was still a small amount of small "fish eye"-shaped micelles in the water. Stirring was continued for 6 minutes, and the viscosity of the feed liquid was tested. The viscosity was 85mpas at 6rpm, which was larger than the viscosity of the feed liquid obtained by stirring with a screen colander, indicating that the hydration was more complete. Continue stirring for 2 hours and test the viscosity of the liquid, which is about 105 mPa.s. This indicates that for this type of untreated xanthan gum with a finer particle size, using a spider web colander to stir can relatively better accelerate the hydration rate.

[0161] Example 5

[0162] The suspending agent composition of this example is a granule prepared by mixing xanthan gum and maltodextrin, and the composition is shown in Table 5-1.

[0163] Table 5-1

[0164] Components Xanthan gum Maltodextrin Quality content 25％ 75.0％

[0165] The preparation process of the suspending agent composition is as follows: after xanthan gum and maltodextrin are evenly mixed, a small amount of water is added to grind to obtain a viscous colloid, which is then spread on a dry glass plate, heated to 100° C. in a forced ventilation furnace and dried for about 20 minutes, and then crushed after drying, and the particles between 30 mesh and 60 mesh are cut, and then packed into a bag.

[0166] The method for preparing the suspension is: pour 20g of the suspending agent composition into 6L of water (about 1min), and stir with a 40-mesh colander while pouring. During the pouring process, a few small "fish eye"-shaped micelles can be seen in the water, but they can be dispersed immediately after stirring. Continue to stir and continue to hydrate the composition particles in the water. After stirring for 2 minutes, a small amount of "fish eye"-shaped micelles can be seen (which should be formed by the hydration of the composition particles themselves). Continue to stir for 6 minutes, test the viscosity of the feed liquid, which is 100mpas at 6rpm, continue to stir, and test the viscosity of the feed liquid at 2h, which is about 105mPa.s at 6rpm. It shows that after stirring for 6 minutes, the xanthan gum has been fully hydrated. It is ideal to use a colander to complete the preparation of the suspension within 6 minutes on site.

[0167] Example 6

[0168] The suspending agent composition of this example is composed of xanthan gum (40 mesh) and sodium sulfate (ie, sodium sulfate), as shown in Table 6-1.

[0169] Table 6-1

[0170] Components Xanthan gum (40 mesh) Yuan Ming powder Weight content 25％ 75.0％

[0171] The preparation process of the suspending agent composition of this embodiment is as follows: 40 mesh xanthan gum and glauber salt are mixed evenly.

[0172] The method for preparing the suspension by stirring with a straight stick is as follows: pour 20 g of the suspending agent composition of the present embodiment into 6 L of water, stir with a straight stick while pouring, a small amount of small "fish-eye" shaped micelles are seen in the water after pouring, and they are immediately dispersed after stirring. After stirring for 2 minutes, a small amount of small "fish-eye" shaped micelles are still seen (this should be formed by the hydration of the xanthan gum particles themselves), and stirring is continued for 7 minutes. Small "fish-eye" shaped micelles can still be seen in the feed liquid. The viscosity of the test feed liquid is 40 mPas at 6 rpm. Stirring is continued for 2 hours, and a small amount of small "fish-eye" shaped micelles can still be seen, indicating that the xanthan gum is not completely hydrated. The viscosity of the test feed liquid is about 90 mPa.s, indicating that the 40-mesh xanthan gum particles cannot be completely hydrated after stirring with a straight stick for 2 hours.

[0173] The method of preparing the suspension by stirring with a 40-mesh colander is as follows: 20 g of the suspending agent composition of the present embodiment is poured into 6 L of water, and a 40-mesh colander is used to stir while pouring. A small amount of micelles are seen sticking to the colander just after pouring into the water, and they are dispersed immediately after stirring. After stirring for 2 minutes, there are still a small amount of small "fish-eye" micelles in the feed liquid. After continuing to stir for 7 minutes, basically no micelles can be seen. The viscosity of the feed liquid is tested, and the viscosity is 103 mPas at 6 rpm. After continuing to stir for 2 hours, the viscosity of the feed liquid is tested, which is about 107 mPa.s. It is explained that stirring with a colander can significantly increase the hydration rate of larger particles of xanthan gum.

[0174] The method of using spider web type colander to stir and prepare suspension is: 20g suspending agent composition of the present embodiment is poured into 6L water, and spider web type colander is used to stir while pouring, and stirred for 2 minutes, and it is seen that there is little "fish eye" shape micelle in the water, and stirring is continued to 7 minutes, and it is still seen that there is little "fish eye" shape micelle in the feed liquid. The viscosity of the test feed liquid is 80mpas at 6rpm, and stirring is continued to 2h, and the viscosity of the test feed liquid is about 107mPa.s, which illustrates that the hydration speed of 40 order xanthan gum particles can be improved by using spider web type colander to stir, but the stirring effect of the screen type colander of 40 order mesh is poor. It can be seen that using which tool to stir has a certain relationship with xanthan gum particle diameter etc.

[0175] Example 7

[0176] The suspending agent composition of this example is composed of xanthan gum (50 mesh) surface-treated with glyoxal, sodium alginate, potassium chloride and maltodextrin, as shown in Table 7-1.

[0177] Table 7-1

[0178]

[0179] The preparation process of the suspending agent composition of this embodiment is as follows: xanthan gum treated with glyoxal (50 mesh, the glyoxal treatment process is the same as that of Example 3), sodium alginate, potassium chloride and maltodextrin are uniformly mixed.

[0180] The method for preparing the suspension is as follows: 2.5 g of the suspending agent composition of this embodiment is poured into 1 L of water (about 30 s), and a glass rod is used to stir during the pouring process. A small amount of "fish-eye"-like micelles can be seen in the water when it is just added, but they are immediately dispersed after stirring. After adding, stirring is continued for 10 minutes. There is basically no "fish-eye"-like micelle in the liquid. The viscosity of the test liquid is 149 mPas at 6 rpm. Stirring is continued for 2 hours. The viscosity of the test liquid is about 147 mPa.s.

[0181] Example 8

[0182] The suspending agent composition of this example is composed of surface-treated xanthan gum (50 mesh), delayed dissolution hydroxypropyl methylcellulose (80 mesh) and glucose, as shown in Table 8-1.

[0183] Table 8-1

[0184]

[0185] The preparation process of the suspending agent composition of this embodiment is as follows: surface-treated xanthan gum particles (50 mesh, glyoxal treatment process Example 3) and hydroxypropyl methylcellulose (80 mesh, treated with glyoxal, the method is referred to patent application CN 105954148 A, or commercially available) for delayed dissolution are respectively taken and mixed evenly with glucose.

[0186] The method for preparing the suspension is as follows: 15 g of the suspending agent composition of the present embodiment is poured into 6 L of water at one time (about 1 min), and a 40-mesh screen colander is used to stir while pouring (the colander mainly provides a larger stirring area at this time), and after adding, stirring is continued for 6 min, and the viscosity of the feed liquid is measured to be 145 mPa.s. After stirring for 2 h, the viscosity of the feed liquid is measured to be 148 mPa.s, indicating that the suspending agent composition of the present invention has basically completed hydration in 6 minutes.

[0187] Example 9

[0188] The suspending agent composition of this example is composed of xanthan gum, maltodextrin and glucose, as shown in Table 9-1.

[0189] Table 9-1

[0190] Components Xanthan gum Maltodextrin glucose Weight content 40.0％ 30.0％ 30.0％

[0191] The preparation process of the suspending agent composition of this embodiment is as follows: xanthan gum, maltodextrin and glucose are mixed respectively, and water is added to grind them into a colloid state, and then the above mixture is spread on a dry glass plate, and heated to a temperature of 100° C. in a forced ventilation furnace and dried for about 20 minutes. Stir from time to time for the first 10 minutes to ensure uniform drying. Then grind and pass through 80 mesh and 200 mesh screens to obtain the middle part to obtain the suspending agent composition 9A.

[0192] Also according to the above method, glyoxal solution was used instead of water to prepare the suspending agent composition (the amount of glyoxal was 0.1% of the weight of xanthan gum). Finally, the middle part was obtained by grinding and passing through 80 mesh and 200 mesh screens to obtain the suspending agent composition 9B.

[0193] The method for preparing the suspension is as follows: 70 g of the suspending agent composition 9A of the present embodiment is poured into 30 L of water (about 1 min). During the pouring process, a stirring rod is used to stir the mixture. A large number of "fish-eye"-shaped micelles of uncontrollable size are formed in the water, which are difficult to eliminate. However, if a 40-mesh screen colander is used for stirring, a large number of "fish-eye"-shaped micelles of uncontrollable size can be seen in the water at the beginning, and a large number of micelles adhere to the colander.

[0194] Suspending agent composition 9B is poured into 30L water (about 1min), stirring rod is used to stir in the pouring process, and a small amount of "fish eye" shape micelle can be seen in the water at the beginning, but disperse immediately when continuing to stir; and 40 order colanders are used to stir (colander can provide larger stirring area, does not provide shear force substantially), a small amount of agglomerates are seen in the water at the beginning and a small amount of agglomerates are adhered to the colander, but continuing to stir and disperse and disappear very quickly. The suspending agent composition made of xanthan gum and maltodextrin processed by illustrating the use of glyoxal, when preparing suspension, stirring rod can be used to disperse well, and colander is used to stir and can be dispersed better. When utilizing the suspending agent composition of the present embodiment to prepare suspension, preparation can be completed in stirring 10 minutes substantially, easy to use, suitable for on-site use in breeding farms.

[0195] The above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. The above embodiment of the present invention can also be modified in various ways. That is, all simple, equivalent changes and modifications made according to the claims and the contents of the specification of the present invention fall within the scope of protection of the claims of the present invention. The contents not described in detail in the present invention are all conventional technical contents.

Claims

1. A suspension agent composition for poultry and livestock, characterized in that: The suspending agent composition comprises: A suspending agent, and optionally one or more of the following components: Excipients, edible dyes and water softeners, The suspending agent is a particle with a particle size of 0.1 mm to 1 mm, or the composition formed by the suspending agent and optional auxiliary materials and / or edible dyes and / or water softeners is a particle with a particle size of 0.1 mm to 1 mm, The suspending agent is selected from short rheological suspending agents. Preferably, the short rheological suspending agent is selected from xanthan gum, sodium alginate, potassium alginate, ammonium alginate, carrageenan, guar gum, pectin, sesbania gum, fenugreek gum, papaya seed gum, plantain seed gum, artemisia seed gum, gum arabic, ghatti gum, dextran, welan gum, sodium carboxymethyl cellulose, ammonium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, soluble starch, pregelatinized starch, carboxymethyl starch, polyethylene oxide, or a combination thereof.

2. The suspending agent composition for poultry and livestock according to claim 1, characterized in that: The suspending agent is selected from xanthan gum or modified xanthan gum, Preferably, the modified xanthan gum is aldehyde-modified xanthan gum. Preferably, the aldehyde is glyoxal.

3. The poultry and livestock suspending agent composition according to claim 1 or 2, characterized in that: The auxiliary material is selected from glucose, fructooligosaccharide, manno-oligosaccharide, water-soluble starch, sucrose, maltodextrin, sodium sulfate, potassium sulfate, ammonium sulfate, magnesium sulfate, sodium chloride, potassium chloride, ammonium chloride, magnesium chloride, potassium phosphate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate, sodium phosphate, disodium hydrogen phosphate, sodium dihydrogen phosphate, ammonium phosphate, diammonium hydrogen phosphate, ammonium dihydrogen phosphate, potassium polyphosphate, potassium tripolyphosphate, sodium polyphosphate, sodium tripolyphosphate, ammonium polyphosphate, ammonium tripolyphosphate, polyethylene glycol, or a combination thereof, and / or The dye is selected from brilliant blue, indigo, lemon yellow, carmine, amaranth, carbon black, or a combination thereof, and / or The water softener is selected from imide sulfonates, amino-containing carboxylic acids and their derivatives, hydroxyl-containing carboxylic acids and their derivatives, polyphosphates, or a combination thereof.

4. The poultry and livestock suspending agent composition according to claim 1 or 2, characterized in that: Based on the total weight of the suspending agent composition, the weight percentage content of the suspending agent is 20-100%, and the weight percentage content of the auxiliary material is 0-80%.

5. The poultry and livestock suspending agent composition according to claim 4, characterized in that: The weight percentage of the suspending agent is 30-80%, preferably 40-70%, and / or The weight percentage of the auxiliary material is 10-70%, preferably 20-60%, and / or The particle size of the granular suspending agent is 0.25 mm to 1 mm, more preferably 0.30 mm to 0.84 mm, or the particle size of the granular composition formed by the suspending agent and optional auxiliary materials and / or edible dyes and / or water softeners is 0.25 mm to 1 mm, more preferably 0.30 mm to 0.84 mm.

6. The poultry and livestock suspending agent composition according to claim 2, characterized in that: The suspending agent composition comprises xanthan gum or modified xanthan gum, and auxiliary materials selected from the following: One or more of sodium sulfate, potassium sulfate, ammonium sulfate, magnesium sulfate, sodium chloride, potassium chloride, ammonium chloride, magnesium chloride, potassium phosphate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate, sodium phosphate, disodium hydrogen phosphate, sodium dihydrogen phosphate, ammonium phosphate, diammonium hydrogen phosphate, ammonium dihydrogen phosphate, potassium polyphosphate, potassium tripolyphosphate, sodium polyphosphate, sodium tripolyphosphate, ammonium polyphosphate, and ammonium tripolyphosphate, The mass ratio of xanthan gum or modified xanthan gum to the auxiliary material is 1:0.2-4, and The xanthan gum or modified xanthan gum is in the form of particles with a particle size of 0.1 mm to 1 mm, or the composition formed by the xanthan gum or modified xanthan gum and the auxiliary materials is in the form of particles with a particle size of 0.1 mm to 1 mm.

7. The method for preparing the suspension agent composition for poultry and livestock according to any one of claims 1 to 6, characterized in that: The preparation method comprises the steps of: providing a suspending agent, and optionally The suspending agent is mixed evenly with auxiliary materials and / or edible dyes and / or water softeners. The suspending agent is a particle with a particle size of 0.1 mm to 1 mm. or The preparation method comprises the steps of: providing a suspending agent, and optionally The suspending agent is uniformly mixed with auxiliary materials and / or edible dyes and / or water softeners to prepare particles with a particle size of 0.1 mm to 1 mm.

8. A method for preparing a suspension, characterized in that: The method comprises the steps of: adding the suspending agent composition according to any one of claims 1 to 6 into water under stirring, and continuing to stir until the suspending agent therein is completely hydrated to obtain a suspension of desired viscosity; Preferably, a tool having a mesh structure is used for stirring, and the ratio of the aperture of the mesh structure to the average particle size of the granular suspending agent or the granular suspending agent composition is 0.3 to 1:

1.

9. Use of the suspension agent composition for poultry and livestock according to any one of claims 1 to 6 in preparing a suspension for suspending coccidia oocyst vaccines, solid pharmaceutical particles or feed additives.

10. The use according to claim 9, characterized in that The method for preparing a suspension for suspending a coccidia oocyst vaccine, a solid granular drug or a feed additive using the suspending agent composition comprises the following steps: (1) adding the suspending agent composition to water while stirring, and continuing to stir until the suspending agent is completely hydrated to obtain a suspension of desired viscosity. Preferably, the stirring is performed using a tool having a mesh structure, wherein the ratio of the aperture of the mesh structure to the average particle size of the granular suspending agent or the suspending agent composition is 0.3 to 1:

1. (2) adding the coccidia oocyst vaccine, solid granular drug or feed additive into the suspension and uniformly dispersing the suspension therein; or, The method for preparing a suspension for suspending a coccidia oocyst vaccine, a solid granular drug or a feed additive using the suspending agent composition comprises the following steps: (1) adding the coccidia oocyst vaccine, solid granular medicine or feed additive into water, (2) adding the suspending agent composition to the water containing the coccidial oocyst vaccine, solid granular drug or feed additive obtained in step (1) under stirring, and continuing to stir until the suspending agent is completely hydrated to obtain a suspension in which the coccidial oocyst vaccine, solid granular drug or feed additive is evenly dispersed, Preferably, the stirring is performed using a tool having a mesh structure, wherein the ratio of the aperture of the mesh structure to the average particle size of the granular suspending agent or the suspending agent composition is 0.3 to 1:1, and the granular suspending agent or the suspending agent composition is uniformly dispersed therein. Preferably, the coccidia oocyst vaccine is selected from the group consisting of chicken coccidia oocyst vaccine, rabbit coccidia oocyst vaccine, pigeon coccidia oocyst vaccine, duck coccidia oocyst vaccine, goose coccidia oocyst vaccine, pig coccidia oocyst vaccine, cattle coccidia oocyst vaccine, sheep coccidia oocyst vaccine, dog coccidia oocyst vaccine, cat coccidia oocyst vaccine, and guinea pig coccidia oocyst vaccine. Preferably, the solid particle drug is selected from a drug suspension, preferably, the drug suspension is selected from albendazole suspension, toltrazuril suspension, Preferably, the feed additive is selected from vitamin additives, trace element additives, and probiotic additives.

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