Device for stereotactic radiotherapy of pulmonary arterial hypertension

Abstract

The invention discloses a device for stereotactic radiotherapy of pulmonary arterial hypertension, which belongs to the field of stereotactic radiotherapy equipment and comprises a data acquisition device, an image processing device, an image processing device, an image processing device and a display device, and is characterized in that the data acquisition device is used for acquiring a pulmonary artery image of a patient to be treated; the image processing device is used for confirming the position and range of pulmonary artery sympathetic nerves based on the pulmonary artery image; the control device is used for controlling the irradiation position area and the irradiation dose of the stereotactic radiotherapy equipment based on the position and the range of the pulmonary artery sympathetic nerves; the irradiation position area comprises a first irradiation area and a second irradiation area; the pulmonary artery structure and the position and the range of pulmonary artery sympathetic nerves of a patient are confirmed through the data acquisition device and the image processing device, and the irradiation position area and the irradiation dose of the stereotactic radiotherapy equipment are regulated according to the positions and the ranges of the pulmonary artery structure and the pulmonary artery sympathetic nerves. The technical effects of applying stereotactic treatment to pulmonary hypertension and removing pulmonary artery sympathetic nerves are achieved.

Description

Technical Field

[0001] The invention relates to the field of stereotactic radiotherapy equipment, in particular to a device for stereotactic radiotherapy of pulmonary hypertension. Background Art

[0002] Stereotactic body radiation therapy (SBRT), also known as stereotactic ablative radiotherapy (SABR). Stereotactic body radiation therapy is commonly used in the treatment of tumors. It is a type of non-surgical radiotherapy that uses stereotactic radiotherapy technology and high-dose, low-fractionation treatment mode to directly ablate tumors with high doses. Specifically, the high-dose radiation therapy rays are accurately projected onto the tumor lesions in the body, so that the tumor is irradiated with a high dose and the normal tissue around the tumor is irradiated with a low dose. The rays of stereotactic radiotherapy are focused to one point from all directions. The dose irradiated to the tumor is very high, while the dose irradiated to the surrounding normal tissue is very low. The most important thing is to find the location of the tumor. As long as the location of the tumor is determined, the surrounding normal tissue can completely avoid the radiation. Because the dose of radiation received by the tumor tissue can reach a very high dose, the therapeutic effect will also be very good. In fact, the gamma knife (γ knife) and X-knife that people often talk about are a kind of stereotactic radiotherapy, but now this stereotactic radiotherapy is no longer used only in the skull as it was originally, but now it is used in various parts of the body. Compared with conventional radiotherapy, stereotactic radiotherapy has the advantages of high dose per fraction, short treatment time (1-2 weeks), high biological effect, good therapeutic effect and protection of normal tissue.

[0003] At present, stereotactic therapy has been successfully applied to cardiomyopathies such as hypertrophic obstructive cardiomyopathy (HOCM). Pulmonary hypertension is a pathophysiological state caused by abnormally elevated pulmonary artery pressure due to a variety of known or unknown reasons. Patients with pulmonary hypertension are difficult to diagnose at an early stage, difficult to treat, and have a poor prognosis. After the onset of symptoms, they often die from uncontrollable right heart failure. Clinically, pulmonary hypertension is divided into five categories: arterial pulmonary hypertension, pulmonary hypertension caused by left heart disease, pulmonary hypertension caused by lung disease, chronic thromboembolic pulmonary hypertension, and pulmonary hypertension caused by multiple factors. A large amount of evidence shows that overactivity of the sympathetic nervous system is related to the progression of PAH. If the sympathetic nerves of the pulmonary artery can be removed, pulmonary hypertension can be effectively treated.

[0004] In view of this, how to provide a device for applying stereotactic treatment to pulmonary hypertension and removing the pulmonary artery sympathetic nerves is a technical problem that people in this field urgently need to solve. Summary of the invention

[0005] The purpose of the present invention is to provide a device for stereotactic radiotherapy of pulmonary hypertension to solve the problems existing in the prior art and to realize the application of stereotactic therapy to pulmonary hypertension and the removal of pulmonary artery sympathetic nerves.

[0006] To achieve the above object, the present invention provides the following solution: The present invention provides a device for stereotactic radiotherapy of pulmonary hypertension, comprising:

[0007] A data acquisition device, the data acquisition device is used to acquire a pulmonary artery image of a patient to be treated;

[0008] An image processing device, the image processing device being used to confirm the position and range of the pulmonary artery sympathetic nerve based on the pulmonary artery image;

[0009] A control device, the control device is used to control the irradiation position area and irradiation dose of the stereotactic radiotherapy device based on the position and range of the pulmonary artery sympathetic nerve; the irradiation position area includes a first irradiation area and a second irradiation area, the first irradiation area corresponds to the position and range of the pulmonary artery sympathetic nerve, the outer edge of the first irradiation area covers the pulmonary artery sympathetic nerve and the outer edge of the first irradiation area is no more than 0.1mm away from the pulmonary artery sympathetic nerve, the second irradiation area does not overlap with the first irradiation area, the second irradiation area is located outside the first irradiation area, and the irradiation dose corresponding to the first irradiation area is greater than the irradiation dose corresponding to the second irradiation area.

[0010] Furthermore, the second irradiation area is linear or annular, and the area of ​​the first irradiation area is greater than that of the second irradiation area by more than 93%.

[0011] Furthermore, the area of ​​the first irradiation region is 94.7% larger than the area of ​​the second irradiation region.

[0012] Furthermore, the irradiation dose corresponding to the first irradiation area is more than 95% higher than the irradiation dose corresponding to the second irradiation area.

[0013] Furthermore, the irradiation dose corresponding to the first irradiation area is 97.6% higher than the irradiation dose corresponding to the second irradiation area.

[0014] Furthermore, the pulmonary artery image is an enhanced CT image of the pulmonary artery of a patient suffering from pulmonary hypertension.

[0015] Furthermore, the image processing device establishes a three-dimensional model of the pulmonary artery based on the pulmonary artery enhanced CT image and confirms the position and range of the pulmonary artery sympathetic nerves based on the three-dimensional model of the pulmonary artery.

[0016] The present invention discloses the following technical effects:

[0017] The present application confirms the patient's pulmonary artery anatomical structure and the position and range of the pulmonary artery sympathetic nerves through a data acquisition device and an image processing device, and uses this as a basis for regulating the irradiation position area and irradiation dose of a stereotactic radiotherapy device; adopts a preferred irradiation area and irradiation dose to improve the removal effect of the pulmonary artery sympathetic nerves and effectively avoid the surrounding tissues from being affected by irradiation; and achieves the technical effect of applying stereotactic therapy to pulmonary hypertension and removing the pulmonary artery sympathetic nerves. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0019] Figure 1 is a flow chart of the method for using the stereotactic radiotherapy device of the present invention; DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0022] The present invention provides a device for stereotactic radiotherapy of pulmonary hypertension to solve the problems existing in the prior art, and can realize the application of stereotactic therapy to pulmonary hypertension and the removal of pulmonary artery sympathetic nerves.

[0023] To achieve the above-mentioned purpose, the present invention provides the following scheme: The present invention provides a device for stereotactic radiotherapy of pulmonary hypertension, comprising: a data acquisition device, the data acquisition device is used to acquire a pulmonary artery image of a patient to be treated; an image processing device, the image processing device is used to confirm the position and range of the pulmonary artery sympathetic nerves based on the pulmonary artery image; a control device, the control device is used to control the irradiation position area and irradiation dose of the stereotactic radiotherapy device based on the position and range of the pulmonary artery sympathetic nerves; the irradiation position area comprises a first irradiation area and a second irradiation area, the first irradiation area corresponds to the position and range of the pulmonary artery sympathetic nerves, the outer edge of the first irradiation area covers the pulmonary artery sympathetic nerves and the outer edge of the first irradiation area is no more than 0.1 mm away from the pulmonary artery sympathetic nerves, the second irradiation area does not overlap with the first irradiation area, the second irradiation area is located outside the first irradiation area, and the irradiation dose corresponding to the first irradiation area is greater than the irradiation dose corresponding to the second irradiation area.

[0024] The second irradiation area is linear or annular, and the area of ​​the first irradiation area is more than 93% larger than the area of ​​the second irradiation area. In this embodiment, the area of ​​the first irradiation area is preferably 94.7% larger than the area of ​​the second irradiation area. The irradiation dose corresponding to the first irradiation area is more than 95% higher than the irradiation dose corresponding to the second irradiation area. In this embodiment, the irradiation dose corresponding to the first irradiation area is preferably 97.6% higher than the irradiation dose corresponding to the second irradiation area.

[0025] In this embodiment, the pulmonary artery image is an enhanced CT image of the pulmonary artery of a patient with pulmonary hypertension. The image processing device establishes a 3D lung model based on the enhanced CT image of the pulmonary artery and confirms the position and range of the sympathetic nerves of the pulmonary artery based on the 3D lung model.

[0026] like Figure 1 As shown, the specific working process is as follows:

[0027] S1: Perform pulmonary artery enhanced CT on patients with pulmonary hypertension to obtain enhanced CT images of the patients’ pulmonary arteries;

[0028] S2: Use the image processing device in the computer to establish a pulmonary artery enhanced three-dimensional model based on the pulmonary artery enhanced CT image to confirm the location and range of the pulmonary artery sympathetic nerves; according to published research reports, the pulmonary artery sympathetic nerve trunk is located on the left side of the pulmonary artery trunk, and runs to the anterior wall of the left pulmonary artery and the anterior and posterior walls of the right pulmonary artery before the left and right pulmonary arteries are derived;

[0029] S3: The controller inputs parameters into the stereotactic radiotherapy device based on the position and range of the pulmonary artery sympathetic nerves. The stereotactic radiotherapy device confirms the first irradiation area, the second irradiation area, the irradiation dose corresponding to the first irradiation area, and the irradiation dose corresponding to the second irradiation area according to the parameters.

[0030] The present invention discloses a device for stereotactic radiotherapy of pulmonary hypertension. The present application confirms the position and range of the patient's pulmonary artery structure and the pulmonary artery sympathetic nerves through a data acquisition device and an image processing device, and uses this as a basis to regulate the irradiation position area and irradiation dose of the stereotactic radiotherapy equipment. In combination with monitoring data such as heart rate, pulmonary airway resistance, and pulmonary compliance, the irradiation position and irradiation dose can be accurately controlled; the preferred irradiation area and irradiation dose are used to improve the removal effect of the pulmonary artery sympathetic nerves and effectively avoid the surrounding tissues from being affected by the irradiation; and the technical effect of applying stereotactic therapy to pulmonary hypertension and removing the pulmonary artery sympathetic nerves is achieved.

[0031] In the description of the present invention, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0032] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A device for stereotactic radiotherapy of pulmonary hypertension, characterized in that: include: A data acquisition device, the data acquisition device is used to acquire a pulmonary artery image of a patient to be treated; An image processing device, the image processing device being used to confirm the position and range of the pulmonary artery sympathetic nerve based on the pulmonary artery image; A control device, the control device is used to control the irradiation position area and irradiation dose of the stereotactic radiotherapy device based on the position and range of the pulmonary artery sympathetic nerve; the irradiation position area includes a first irradiation area and a second irradiation area, the first irradiation area corresponds to the position and range of the pulmonary artery sympathetic nerve, the outer edge of the first irradiation area covers the pulmonary artery sympathetic nerve and the outer edge of the first irradiation area is no more than 0.1mm away from the pulmonary artery sympathetic nerve, the second irradiation area does not overlap with the first irradiation area, the second irradiation area is located outside the first irradiation area, and the irradiation dose corresponding to the first irradiation area is greater than the irradiation dose corresponding to the second irradiation area.

2. The device for stereotactic radiotherapy of pulmonary hypertension according to claim 1, characterized in that: The second irradiation area is linear or annular, and the area of ​​the first irradiation area is greater than that of the second irradiation area by more than 93%.

3. The device for stereotactic radiotherapy of pulmonary hypertension according to claim 2, characterized in that: The area of ​​the first irradiation region is 94.7% larger than the area of ​​the second irradiation region.

4. The device for stereotactic radiotherapy of pulmonary hypertension according to claim 1, characterized in that: The irradiation dose corresponding to the first irradiation area is more than 95% higher than the irradiation dose corresponding to the second irradiation area.

5. The device for stereotactic radiotherapy of pulmonary hypertension according to claim 4, characterized in that: The irradiation dose corresponding to the first irradiation area is 97.6% higher than the irradiation dose corresponding to the second irradiation area.

6. The device for stereotactic radiotherapy of pulmonary hypertension according to claim 1, characterized in that: The pulmonary artery image is an enhanced CT image of the pulmonary artery of a patient suffering from pulmonary hypertension.

7. The device for stereotactic radiotherapy of pulmonary hypertension according to claim 6, characterized in that: The image processing device establishes a pulmonary artery three-dimensional model according to the pulmonary artery enhanced CT image and confirms the position and range of the pulmonary artery sympathetic nerves according to the pulmonary artery three-dimensional model.

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