Heterocyclic carbonyl derivative regulator as well as preparation method and application thereof

Abstract

The invention relates to a heterocyclic carbonyl derivative regulator as well as a preparation method and application thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method thereof, a pharmaceutical composition containing the compound, and a use thereof as a modulator in the treatment of Alzheimer's disease, schizophrenia, pain, addiction and sleep disorders, each substituent in the general formula (I) being as defined in the specification. # imgabs0 #

Claims

1. A compound represented by general formula (I), its stereoisomer or a pharmaceutically acceptable salt thereof: in: X1 from CR 11 or N; X2 Selected from CR 22 or N; X3 Selected from CR 33 or N; X4 Selected from CR 44 or N; X5 Selected from CR 55 or N; R 11 , R 22 , R 33 , R 44 R1, R2, R3, R4, R5 or R6 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, the amino, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally deuterated, hydroxyl, halogen, cyano, amino, C 1-6 Alkyl, C 1-6 Haloalkyl or C 1-6 is substituted with one or more substituents of a deuterated alkyl group; R 55 , R7, R8, R9, R 10 or R 12 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl, 5-12 membered heteroaryl, -(CR aa R bb ) n1 C(O)R 31 、N=S=OR 31 R 32 、-(CH2) n1 C(O)NR 31 R 32 、-(CH2) n1 P(O)R 31 R 32 、-(CH2) n1 P(O)2R 31 R 32 、-(CR aa R bb ) n1 (NR 31 )C(O)R 32 、-(CR aa R bb ) n1 C(O)NR 31 R 32 、-(CR aa R bb ) n1 (NR 31 )S(O) m1 R 32 、-(CR aa R bb ) n1 S(O) m1 NR 31 R 32 、-(CR aa R bb ) n1 S(O)(=NR cc )R 32 or -(CR aa R bb ) n1 S(O) m1 R 32 , the amino group, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally substituted by deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 aryl or 5-12 membered heteroaryl is substituted with one or more substituents; Alternatively, R1 and R2, R3 and R4, or R5 and R6 are linked to the connected carbon atoms to form a C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally substituted with deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 aryl or 5-12 membered heteroaryl is substituted with one or more substituents; R 31 , R 32 , R 33 , R aa , R bb or R cc are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, the amino, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally deuterated, hydroxyl, halogen, cyano, amino, C 1-6 Alkyl, C 1-6 Haloalkyl or C 1-6 is substituted with one or more substituents of a deuterated alkyl group; The conditions are: (1) At least one of X2, X3 or X4 is N; Or, (2) R1, R2 and the connected carbon atom are linked to form C 3-12 Cycloalkyl or 3-12 membered heterocyclic group; Or, (3) R3, R4 and the connected carbon atom are linked to form C 3-12 Cycloalkyl or 3-12 membered heterocyclic group; Alternatively, (4) R5, R6 and the connected carbon atom form a C 3-12 Cycloalkyl or 3-12 membered heterocyclic group; Or, (5) X1 is CR 11 ; Or, (6) R7, R8, R9, R 10 or R 55 At least one group is selected from N=S=OR 31 R 32 、-(CH2) n1 P(O)R 31 R 32 、-(CH2) n1 P(O)2R 31 R 32 、-(CR aa R bb ) n1 S(O)(=NR cc )R 32 or -(CR aa R bb ) n1 S(O) m1 R 32 ; or, (7) at least one of R1, R2, R3 or R4 is not hydrogen or methyl; or (8) R5, R6 or R 12 At least one of the groups is not hydrogen; Or, (9) at least one of X1, X2, X3 or X4 is N, and R 11 , R 22 , R 33 or R 44 At least one of the groups is C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally substituted by deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 aryl or 5-12 membered heteroaryl is substituted with one or more substituents; m1 is 0, 1 or 2; and n1 is 0, 1 or 2; Preferably, the compound is further represented by general formula (I-1), (I-2), (I-3), (I-4) or (I-5): Ring A is selected from C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 One or more substituents in the alkyl group are substituted; More preferably, the compound is further represented by general formula (I-6) or (I-7): in: R8 or R 55 At least one group is selected from N=S=OR 31 R 32 、-(CH2) n1 P(O)R 31 R 32 、-(CH2) n1 P(O)2R 31 R 32 、-(CR aa R bb ) n1 S(O)(=NR cc )R 32 or -(CR aa R bb ) n1 S(O) m1 R 32 ; R 31 or R 32 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C containing 1-3 atoms selected from N, O or S 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C containing 1-3 atoms selected from N, O or S 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, hydroxyl, halogen, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 is substituted with one or more substituents of a deuterated alkyl group; Preferably, R 31 or R 32 each independently selected from hydrogen, deuterium, fluorine, chlorine, bromine, amino, methylamino, dimethylamino, hydroxyl, cyano, nitro, methyl, ethyl, isopropyl, fluoromethyl, fluoroethyl, difluoromethyl, difluoroethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, aminomethyl, methoxy, ethoxy or propoxy; R aa , R bb or R cc are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 Alkyl, the amino, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 Alkyl, optionally deuterated, hydroxy, halogen, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 is substituted with one or more substituents of a deuterated alkyl group; Preferably, R aa , R bb or R cc each independently selected from hydrogen, deuterium, fluorine, chlorine, bromine, amino, methylamino, dimethylamino, hydroxy, cyano, nitro, methyl, ethyl, isopropyl, fluoromethyl, fluoroethyl, difluoromethyl, difluoroethyl, trifluoromethyl, trifluoroethyl, aminomethyl, methoxy, ethoxy or propoxy; More preferably, the compound is further represented by general formula (I-8) or (I-9): in, In formula (I-8), R 22 , R 33 or R 44 At least one group is selected from C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally deuterated, hydroxyl, halogen, cyano, amino, C 1-6 Alkyl, C 1-6 Haloalkyl or C 1-6 is substituted with one or more substituents of a deuterated alkyl group; In formula (I-9), R 11 , R 33 or R 44 At least one group is selected from C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally deuterated, hydroxyl, halogen, cyano, amino, C 1-6 Alkyl, C 1-6 Haloalkyl or C 1-6 The deuterated alkyl group is substituted with one or more substituents.

2. A compound represented by general formula (III), its stereoisomer or a pharmaceutically acceptable salt thereof: in: X1 from CR 11 or N; X2 Selected from CR 22 or N; X3 Selected from CR 33 or N; X4 Selected from CR 44 or N; X5 Selected from CR 55 or N; At least one of X1 to X4 is N; R 11 , R 22 , R 33 , R 44 R1, R3, R5 or R6 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, the amino, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally deuterated, hydroxyl, halogen, cyano, amino, C 1-6 Alkyl, C 1-6 Haloalkyl or C 1-6 is substituted with one or more substituents of a deuterated alkyl group; R 55 , R7, R8, R9, R 10 or R 12 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl, 5-12 membered heteroaryl, -(CR aa R bb ) n1 C(O)R 31 、N=S=OR 31 R 32 、-(CH2) n1 C(O)NR 31 R 32 、-(CH2) n1 P(O)R 31 R 32 、-(CH2) n1 P(O)2R 31 R 32 、-(CR aa R bb ) n1 (NR 31 )C(O)R 32 、-(CR aa R bb ) n1 C(O)NR 31 R 32 、-(CR aa R bb ) n1 (NR 31 )S(O) m1 R 32 、-(CR aa R bb ) n1 S(O) m1 NR 31 R 32 、-(CR aa R bb ) n1 S(O)(=NR cc )R 32 or -(CR aa R bb ) n1 S(O) m1 R 32 , the amino group, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally substituted by deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 aryl or 5-12 membered heteroaryl is substituted with one or more substituents; Alternatively, R5, R6 and the connected carbon atom are linked to form a C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally substituted with deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 aryl or 5-12 membered heteroaryl is substituted with one or more substituents; R 31 , R 32 , R 33 , R aa , R bb or R cc are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, the amino, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally deuterated, hydroxyl, halogen, cyano, amino, C 1-6 Alkyl, C 1-6 Haloalkyl or C 1-6 is substituted with one or more substituents of a deuterated alkyl group; m1 is 0, 1 or 2; and n1 is 0, 1 or 2; Preferably, X1 is N; X2 for CR 22 ; X3 for CR 33 ; X4 for CR 44 ; X5 is N; R 22 , R 33 or R 44 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, hydroxyl, halogen, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 The deuterated alkyl group is substituted with one or more substituents.

3. A compound represented by general formula (IV), (V) or (VI), a stereoisomer thereof or a pharmaceutically acceptable salt thereof: in: X1 from CR 11 or N; X2 Selected from CR 22 or N; X3 Selected from CR 33 or N; X4 Selected from CR 44 or N; X5 Selected from CR 55 or N; X9 from CR 99 or N; L1 is selected from C(CF3)R 66 、C(O), C(=S), C(=NR 66 ) or S(O) n2 ; L2 is selected from C 2-6 Alkenylene, C 2-6 Alkynylidene, C 3-12 Cycloalkylene, 3-12 membered heterocyclylene, C 6-12 Arylene or 5-12 membered heteroarylene; Ring D is selected from C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 One or more substituents in the alkyl group are substituted; R 11 , R 22 , R 33 , R 44 , R 66 , R 99 R1, R2, R3, R4, R5 or R6 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, the amino, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally deuterated, hydroxyl, halogen, cyano, amino, C 1-6 Alkyl, C 1-6 Haloalkyl or C 1-6 is substituted with one or more substituents of a deuterated alkyl group; R 55 , R7, R8, R9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl, 5-12 membered heteroaryl, -(CR aa R bb ) n1 C(O)R 31 、N=S=OR 31 R 32 、-(CH2) n1 C(O)NR 31 R 32 、-(CH2) n1 P(O)R 31 R 32 、-(CH2) n1 P(O)2R 31 R 32 、-(CR aa R bb ) n1 (NR 31 )C(O)R 32 、-(CR aa R bb ) n1 C(O)NR 31 R 32 、-(CR aa R bb ) n1 (NR 31 )S(O) m1 R 32 、-(CR aa R bb ) n1 S(O) m1 NR 31 R 32 、-(CR aa R bb ) n1 S(O)(=NR cc )R 32 or -(CR aa R bb ) n1 S(O) m1 R 32 , the amino group, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl, 5-12 membered heteroaryl, optionally substituted with deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 aryl or 5-12 membered heteroaryl is substituted with one or more substituents; Alternatively, R1 and R2, R3 and R4, or R5 and R6 are linked to the connected carbon atoms to form a C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally substituted with deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 aryl or 5-12 membered heteroaryl is substituted with one or more substituents; R 31 , R 32 , R 33 , R aa , R bb or R cc are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, the amino, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally deuterated, hydroxyl, halogen, cyano, amino, C 1-6 Alkyl, C 1-6 Haloalkyl or C 1-6 is substituted with one or more substituents of a deuterated alkyl group; The conditions are: When L1 is C(O), L2 is not m1 is 0, 1 or 2; n1 is 0, 1 or 2; and n2 is 1 or 2; n4 is 0, 1 or 2; Preferably, the compound is further represented by general formula (IV-1), (VI-1) or (VI-2):

4. A compound represented by general formula (VII), its stereoisomer or a pharmaceutically acceptable salt thereof: in: R is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl, 5-12 membered heteroaryl, -(CR aa R bb ) n1 C(O)R 31 、N=S=OR 31 R 32 、-(CH2) n1 C(O)NR 31 R 32 、-(CH2) n1 P(O)R 31 R 32 、-(CH2) n1 P(O)2R 31 R 32 、-(CR aa R bb ) n1 (NR 31 )C(O)R 32 、-(CR aa R bb ) n1 C(O)NR 31 R 32 、-(CR aa R bb ) n1 (NR 31 )S(O) m1 R 32 、-(CR aa R bb ) n1 S(O) m1 NR 31 R 32 、-(CR aa R bb ) n1 S(O)(=NR cc )R 32 or -(CR aa R bb ) n1 S(O) m1 R 32 , the amino group, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally substituted with deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 aryl or 5-12 membered heteroaryl is substituted with one or more substituents; R 31 , R 32 , R 33 , R aa , R bb , R cc , R 22 , R 33 , R 44 R1, R2, R3 or R4 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, the amino, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally deuterated, hydroxyl, halogen, cyano, amino, C 1-6 Alkyl, C 1-6 Haloalkyl or C 1-6 is substituted with one or more substituents of a deuterated alkyl group; Alternatively, R1 and R2 or R3 and R4 are linked to the carbon atoms to form a C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally substituted with deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 aryl or 5-12 membered heteroaryl is substituted with one or more substituents; m1 is 0, 1 or 2; and n1 is 0, 1 or 2; Preferably, the compound is further represented by general formula (VII-1): L3 is a key, (CR 66 R 77 ) n2 NR 88 , (CR 66 R 77 ) n2 NR 88 NR 88 (CR 66 R 77 ) n2 , O, S, C 2-6 Alkenylene, C 2-6 Alkynylene, C(O) or S(O) n1 ; Preferably, L3 is selected from a bond, (CH2) n2 , C 2-4 Alkenyl or C 2-4 Alkynyl; More preferably, L3 is selected from a bond, methylene, vinylene or ethynylene; R 66 , R 77 or R 88 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, the amino, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally deuterated, hydroxyl, halogen, cyano, amino, C 1-6 Alkyl, C 1-6 Haloalkyl or C 1-6 is substituted with one or more substituents of a deuterated alkyl group; Ring E is selected from C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, the C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl; R0 is independently selected from hydrogen, deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 1-6 Hydroxyalkyl, cyano substituted C 1-6 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl; x is an integer from 0 to 4; and n2 is 0, 1 or 2.

5. The compound according to any one of claims 1 to 4, its stereoisomer or a pharmaceutically acceptable salt thereof, characterized in that: R 11 , R 22 , R 33 or R 44 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, hydroxyl, halogen, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 is substituted with one or more substituents of a deuterated alkyl group; Preferably, R 11 , R 22 , R 33 or R 44 Each is independently selected from hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, methyl, ethyl, propyl, isopropyl, fluoromethyl, difluoromethyl, trifluoromethyl, cyclopropyl, cyclobutyl, oxirane, epoxypropyl or epoxybutyl, wherein the amino, methyl, ethyl, propyl, isopropyl, fluoromethyl, difluoromethyl, trifluoromethyl, cyclopropyl, cyclobutyl, oxirane, epoxypropyl or epoxybutyl is optionally deuterated by deuterium, hydroxyl, halogen, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 The deuterated alkyl group is substituted with one or more substituents.

6. The compound according to any one of claims 1 to 3, its stereoisomer or a pharmaceutically acceptable salt thereof, characterized in that: R8 or R 55 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, deuterated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, -O(CR aa R bb ) n1 R 31 、-N(CR aa R bb ) n1 R 31 、-S(CR aa R bb ) n1 R 31 、-(CR aa R bb ) n1 C(O)R 31 、N=S=OR 31 R 32 、-(CH2) n1 C(O)NR 31 R 32 、-(CH2) n1 P(O)R 31 R 32 、-(CH2) n1 P(O)2R 31 、-(CR aa R bb ) n1 (NR 31 )C(O)R 32 、-(CR aa R bb ) n1 C(O)NR 31 R 32 、-(CR aa R bb ) n1 (NR 31 )S(O) m1 R 32 、-(CR aa R bb ) n1 S(O) m1 NR 31 R 32 、-(CR aa R bb ) n1 S(O)(=NR cc )R 32 or -(CR aa R bb ) n1 S(O) m1 R 32 , the amino group, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, deuterated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S; R 31 , R 32 or R 33 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, hydroxyl, halogen, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 is substituted with one or more substituents of a deuterated alkyl group; Preferably, R 31 , R 32 or R 33 each independently selected from hydrogen, deuterium, fluorine, chlorine, bromine, amino, methylamino, dimethylamino, hydroxyl, cyano, nitro, methyl, ethyl, isopropyl, fluoromethyl, fluoroethyl, difluoromethyl, difluoroethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, aminomethyl, methoxy, ethoxy or propoxy, the amino, methylamino, dimethylamino, methyl, ethyl, isopropyl, fluoromethyl, fluoroethyl, difluoromethyl, difluoroethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, aminomethyl, methoxy, ethoxy or propoxy, optionally deuterated, hydroxyl, fluorine, chlorine, bromine, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 is substituted with one or more substituents of a deuterated alkyl group; R aa , R bb or R cc are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 Alkyl, the amino, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 Alkyl, optionally deuterated, hydroxy, halogen, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 is substituted with one or more substituents of a deuterated alkyl group; Preferably, R aa , R bb or R cc each independently selected from hydrogen, deuterium, fluorine, chlorine, bromine, amino, methylamino, dimethylamino, hydroxy, cyano, nitro, methyl, ethyl, isopropyl, fluoromethyl, fluoroethyl, difluoromethyl, difluoroethyl, trifluoromethyl, trifluoroethyl, aminomethyl, methoxy, ethoxy or propoxy; or, R5 and R6 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, hydroxyl, halogen, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 is substituted with one or more substituents of a deuterated alkyl group; Preferably, R5 or R6 are each independently selected from hydrogen, deuterium, fluorine, chlorine, bromine, amino, methylamino, dimethylamino, hydroxyl, cyano, nitro, methyl, ethyl, isopropyl, fluoromethyl, fluoroethyl, difluoromethyl, difluoroethyl, trifluoromethyl, trifluoroethyl, aminomethyl, methoxy, ethoxy or propoxy; Alternatively, R5, R6 and the connected carbon atom are linked to form a C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S; Preferably, R5, R6 and the connected carbon atom are linked to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 One or more substituents in the alkyl group are substituted; More preferably, R5, R6 and the connected carbon atom are linked to form cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; R7, R9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S; Preferably, R7, R9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 One or more substituents in the alkyl group are substituted; More preferably, R7, R9 or R 10 Each is independently selected from hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, methyl, ethyl, propyl, vinyl, allyl, propenyl, ethynyl, propynyl, propargyl, deuterated methyl, deuterated ethyl, deuterated propyl, fluoromethyl, fluoroethyl, trifluoromethyl, difluoromethyl, methoxy, ethoxy, propoxy, fluorine-substituted methoxy, fluorine-substituted ethoxy, trifluoromethoxy, hydroxymethyl, hydroxyethyl, hydroxypropyl, 2-hydroxypropyl, cyano-substituted methyl, cyano-substituted ethyl, cyano-substituted propyl, cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.

7. The compound according to any one of claims 1 to 4, its stereoisomer or a pharmaceutically acceptable salt thereof, characterized in that: R1 and R2 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, hydroxyl, halogen, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 is substituted with one or more substituents of a deuterated alkyl group; Preferably, R1 or R2 are each independently selected from hydrogen, deuterium, fluorine, chlorine, bromine, amino, methylamino, dimethylamino, hydroxyl, cyano, nitro, methyl, ethyl, isopropyl, fluoromethyl, fluoroethyl, difluoromethyl, difluoroethyl, trifluoromethyl, trifluoroethyl, aminomethyl, methoxy, ethoxy or propoxy; Alternatively, R1, R2 and the connected carbon atom are linked to form a C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S; Preferably, R1, R2 and the connected carbon atom are linked to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 One or more substituents in the alkyl group are substituted; or, R3 and R4 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, hydroxyl, halogen, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 is substituted with one or more substituents of a deuterated alkyl group; Preferably, R3 or R4 are each independently selected from hydrogen, deuterium, fluorine, chlorine, bromine, amino, methylamino, dimethylamino, hydroxyl, cyano, nitro, methyl, ethyl, isopropyl, fluoromethyl, fluoroethyl, difluoromethyl, difluoroethyl, trifluoromethyl, trifluoroethyl, aminomethyl, methoxy, ethoxy or propoxy; Alternatively, R3, R4 and the connected carbon atom are linked to form a C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S; Preferably, R3, R4 and the connected carbon atom are linked to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 The alkyl group is substituted with one or more substituents.

8. The compound according to any one of claims 1 or 2, its stereoisomer or a pharmaceutically acceptable salt thereof, characterized in that: R 12 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S; Preferably, R 12 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 One or more substituents in the alkyl group are substituted; More preferably, R 12 is selected from hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, methyl, ethyl, propyl, vinyl, allyl, propenyl, ethynyl, propynyl, propargyl, deuterated methyl, deuterated ethyl, deuterated propyl, fluoromethyl, fluoroethyl, trifluoromethyl, difluoromethyl, methoxy, ethoxy, propoxy, fluorinated methoxy, fluorinated ethoxy, trifluoromethoxy, hydroxymethyl, hydroxyethyl, hydroxypropyl, 2-hydroxypropyl, cyano-substituted methyl, cyano-substituted ethyl, cyano-substituted propyl, cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.

9. The compound according to claim 1, its stereoisomer or a pharmaceutically acceptable salt thereof, characterized in that: Ring A is selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 N, O or S atoms, wherein the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 aryl or 5-10 membered heteroaryl containing 1-3 N, O or S atoms, optionally substituted by deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 One or more substituents in the alkyl group are substituted; Preferably, ring A is selected from C 3-6 Cycloalkyl, 5-6 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-6 membered heteroaryl containing 1-3 N, O or S atoms, wherein the C 3-6 Cycloalkyl, 5-6 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 aryl or 5-6 membered heteroaryl containing 1-3 N, O or S atoms, optionally substituted by deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 One or more substituents in the alkyl group are substituted; More preferably, ring A is selected from cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, Optionally substituted with one or more substituents of hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, methyl, ethyl, isopropyl, fluoromethyl, fluoroethyl, difluoromethyl, difluoroethyl, trifluoromethyl or trifluoroethyl.

10. The compound according to claim 3, its stereoisomer or a pharmaceutically acceptable salt thereof, characterized in that: Ring D is selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 N, O or S atoms, wherein the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 aryl or 5-10 membered heteroaryl containing 1-3 N, O or S atoms, optionally substituted by deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 One or more substituents in the alkyl group are substituted; Preferably, ring D is selected from C 3-6 Cycloalkyl, 5-6 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-6 membered heteroaryl containing 1-3 N, O or S atoms, wherein the C 3-6 Cycloalkyl, 5-6 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-6 membered heteroaryl containing 1-3 N, O or S atoms, optionally substituted by deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 One or more substituents in the alkyl group are substituted; More preferably, ring D is selected from cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, optionally substituted with one or more substituents of hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, methyl, ethyl, isopropyl, fluoromethyl, fluoroethyl, difluoromethyl, difluoroethyl, trifluoromethyl or trifluoroethyl; or, L2 is selected from C 2-4 Alkenylene, C 2-4 Alkynylidene, C 3-10 Cycloalkylene, 3-10 membered heterocyclylene containing 1-3 N, O or S atoms, C 6-10 Arylene or 5-10 membered heteroarylene containing 1-3 N, O or S atoms; Preferably, L2 is selected from C 2-4 Alkenylene, C 2-4 Alkynylidene, C 3-8 Cycloalkylene, 3-8 membered heterocyclylene containing 1-3 N, O or S atoms, C 6-10 Arylene or 5-8 membered heteroarylene containing 1-3 N, O or S atoms; More preferably, L2 is selected from C 2-4 Alkenylene, C 2-4 Alkynylidene, C 3-6 Monocyclic cycloalkylene, C 3-8 Bridged ring cycloalkylene, C 3-8 Spirocycloalkylene, C 3-6 fused ring cycloalkylene, 3-6 membered monocyclic heterocyclic alkylene containing 1-3 N, O or S atoms, 3-8 membered bridged heterocyclic alkylene containing 1-3 N, O or S atoms, 3-8 membered spiro heterocyclic alkylene containing 1-3 N, O or S atoms, 3-8 membered fused ring heterocyclic alkylene containing 1-3 N, O or S atoms, C 6-10 Arylene, 5-8 membered monocyclic heteroarylene containing 1-3 N, O or S atoms, or 5-8 membered fused-ring heteroarylene containing 1-3 N, O or S atoms; More preferably, L2 is selected from vinylene, ethynylene, 11. The compound according to claim 4, its stereoisomer or a pharmaceutically acceptable salt thereof, characterized in that: Ring E is selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 N, O or S atoms; Preferably, ring E is selected from C 3-6 Cycloalkyl, 5-6 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-6 membered heteroaryl containing 1-3 N, O or S atoms; More preferably, ring E is selected from cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, naphthyl, pyridyl, or, R0 is independently selected from hydrogen, deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 One or more substituents in the alkyl group are substituted; Preferably, R0 is independently selected from hydrogen, deuterium, oxo, thio, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 One or more substituents in the alkyl group are substituted; More preferably, R0 is independently substituted by one or more substituents selected from hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, methyl, ethyl, isopropyl, fluoromethyl, fluoroethyl, difluoromethyl, difluoroethyl, trifluoromethyl or trifluoroethyl; or, R is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, -(CR aa R bb ) n1 C(O)R 31 、N=S=OR 31 R 32 、-(CH2) n1 C(O)NR 31 R 32 、-(CH2) n1 P(O)R 31 R 32 、-(CH2) n1 P(O)2R 31 R 32 、-(CR aa R bb ) n1 (NR 31 )C(O)R 32 、-(CR aa R bb ) n1 C(O)NR 31 R 32 、-(CR aa R bb ) n1 (NR 31 )S(O) m1 R 32 、-(CR aa R bb ) n1 S(O) m1 NR 31 R 32 、-(CR aa R bb ) n1 S(O)(=NR cc )R 32 or -(CR aa R bb ) n1 S(O) m1 R 32 , the amino group, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S; R 31 , R 32 or R 33 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, hydroxyl, halogen, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 is substituted with one or more substituents of a deuterated alkyl group; Preferably, R 31 , R 32 or R 33 each independently selected from hydrogen, deuterium, fluorine, chlorine, bromine, amino, methylamino, dimethylamino, hydroxyl, cyano, nitro, methyl, ethyl, isopropyl, fluoromethyl, fluoroethyl, difluoromethyl, difluoroethyl, trifluoromethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, aminomethyl, methoxy, ethoxy, propoxy, vinyl, propenyl, allyl, ethynyl, propynyl or propargyl; R aa , R bb or R cc are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 Alkyl, the amino, C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl or cyano substituted C 1-3 Alkyl, optionally deuterated, hydroxy, halogen, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 is substituted with one or more substituents of a deuterated alkyl group; Preferably, R aa , R bb or R cc each independently selected from hydrogen, deuterium, fluorine, chlorine, bromine, amino, methylamino, dimethylamino, hydroxy, cyano, nitro, methyl, ethyl, isopropyl, fluoromethyl, fluoroethyl, difluoromethyl, difluoroethyl, trifluoromethyl, trifluoroethyl, aminomethyl, methoxy, ethoxy or propoxy; or, R 66 , R 77 or R 88 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Alkoxy, halogenated C 1-3 Alkoxy, C 1-3 Hydroxyalkyl, cyano substituted C 1-3 Alkyl, C 3-10 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally substituted by deuterium, hydroxyl, halogen, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 is substituted with one or more substituents of a deuterated alkyl group; Preferably, R 66 , R 77 or R 88 Each is independently selected from hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, methyl, ethyl, propyl, isopropyl, fluoromethyl, difluoromethyl, trifluoromethyl, cyclopropyl, cyclobutyl, oxirane, epoxypropyl or epoxybutyl, wherein the amino, methyl, ethyl, propyl, isopropyl, fluoromethyl, difluoromethyl, trifluoromethyl, cyclopropyl, cyclobutyl, oxirane, epoxypropyl or epoxybutyl is optionally deuterated by deuterium, hydroxyl, halogen, cyano, amino, C 1-3 Alkyl, C 1-3 Haloalkyl or C 1-3 The deuterated alkyl group is substituted with one or more substituents.

12. The compound shown below, its stereoisomer or a pharmaceutically acceptable salt thereof, the compound structure is as follows:

13. A pharmaceutical composition comprising a therapeutically effective dose of a compound according to any one of claims 1 to 12, a stereoisomer thereof or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable carriers or excipients.

14. Use of a compound according to any one of claims 1 to 12, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition according to claim 13 in the preparation of a medicament for treating an M4-related disease, wherein the M4-related disease is preferably selected from Alzheimer's disease, schizophrenia or psychosis, pain, addiction, sleep disorders, cognitive disorders, Parkinson's disease, Parkinson's disease-levodopa-induced dyskinesia, Huntington's disease, dry mouth, pulmonary hypertension, chronic obstructive pulmonary disease, asthma, urinary incontinence, glaucoma, Down syndrome, cerebral amyloid angiopathy, dementia, hereditary Dutch amyloidosis cerebral hemorrhage, Creutzfeldt-Jakob disease, prion disease, amyotrophic lateral sclerosis, progressive supranuclear palsy, head trauma, stroke, pancreatitis, inclusion body myositis, other peripheral amyloidosis, diabetes, autism and atherosclerosis, more preferably Alzheimer's disease, schizophrenia, pain, addiction and sleep disorders.

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