Weeding composition containing artesunate and application thereof

Abstract

The invention belongs to the technical field of pesticides, and particularly relates to a weeding composition containing artesunate and application of the weeding composition, active components comprise an active component A and an active component B. The active component A is 9-methoxycamptothecin or 10-methoxycamptothecin; the active ingredient B is artesunate; the mass ratio of the active component A to the active component B is (1: 10)-(10: 1). 9-methoxycamptothecin and 10-methoxycamptothecin have higher herbicidal activity, and are compounded with artesunate to realize a synergistic effect of 9-methoxycamptothecin and 10-methoxycamptothecin; the active component adopted by the invention is a biological source pesticide and is environment-friendly.

Description

Technical Field

[0001] The invention belongs to the technical field of pesticides, and particularly relates to a herbicidal composition comprising artesunate and an application thereof. Background Art

[0002] China has a vast territory, rich plant resources and a long history of agriculture. However, with the strengthening of human social and economic activities, natural resources have been severely damaged. Therefore, the idea of ​​sustainable agricultural development has gradually received attention. Among them, biogenic pesticides have become a hot spot in current pesticide research and development because of their environmental friendliness. They are an effective strategy to resolve the conflict between agricultural development and environmental protection.

[0003] At present, more than 30 families of plants have been found to have weed control effects. In recent years, my country has achieved some relevant scientific research results, some of which are at the forefront of the world, and has a number of plant-based weed control patents with independent intellectual property rights. Now we are in a period of good development opportunities, and we need to study green herbicides with significant results to promote the sustainable development of agriculture. At present, one is to use plant-derived herbicidal active compounds as lead compounds for structural optimization and develop them into green herbicide products with higher activity. For example, herbicides developed based on plant-derived herbicidal active ingredients include cyproconazole, diphenyl ethers, triketides and other categories, all of which have good commercial value; the second is to explore plant-derived herbicidal active ingredients with higher activity, and directly develop plant-derived herbicide products by compounding to enhance synergy and expand the weed control spectrum. For example, the patent document (CN202311662859.4) discloses a compound of 7-ethylcamptothecin and artesunate, and a compound of 7-ethylcamptothecin and paeonol, which have excellent herbicidal activity against barnyard grass, sedge, and Bidens pilosa, and can be directly developed into a plant-derived herbicidal active ingredient composition for the prevention and control of Gramineae, Cyperaceae and broad-leaved weeds in farmland.

[0004] The applicant found that 9-methoxycamptothecin and 10-methoxycamptothecin also have high herbicidal activity. When combined with artesunate, they achieve a synergistic effect and have good control effects on grass weeds such as barnyard grass, crabgrass and goosegrass, sedge weeds such as Cyperus rotundus and Cyperus difformis, and broadleaf weeds such as Bidens pilosa. Summary of the invention

[0005] The present invention provides a biogenic herbicide composition, specifically a herbicide composition containing artesunate and its application. The herbicide composition has a significant synergistic effect, is safe for crops, and is friendly to the environment. The specific technical scheme is as follows:

[0006] A herbicidal composition containing artesunate, wherein the active ingredients consist of an active ingredient A and an active ingredient B, wherein the active ingredient A is 9-methoxycamptothecin or 10-methoxycamptothecin; the active ingredient B is artesunate; and the mass ratio of the active ingredient A to the active ingredient B is 1:10-10:1.

[0007] The preferred mass ratio of active ingredient A to active ingredient B is 1:5-5:1; the more preferred mass ratio of active ingredient A to active ingredient B is 1:5:1:1 or 5:1.

[0008] The herbicidal composition of the present invention comprises agricultural auxiliary material components, and the total weight percentage of active components is 1-70%, and the preferred total weight percentage of active components is 5-50%.

[0009] The herbicidal composition preparation of the present invention is a suspension concentrate, a microcapsule suspension concentrate, a water-dispersible granule, or a wettable powder; preferably a suspension concentrate.

[0010] The herbicidal composition of the present invention is used for controlling weeds in farmland, especially for annual weeds.

[0011] Compared with the prior art, the present invention achieves the following beneficial technical effects:

[0012] 9-methoxycamptothecin and 10-methoxycamptothecin have high herbicidal activity and can be combined with artesunate to achieve a synergistic effect.

[0013] The active ingredient used in the invention is a biogenic pesticide, which is environmentally friendly. DETAILED DESCRIPTION

[0014] Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without making any creative work shall fall within the scope of protection of the present invention.

[0015] Example 1: Indoor joint action test of herbicidal composition against barnyard grass

[0016] Materials and Methods

[0017] Test agents: 9-methoxycamptothecin, 10-methoxycamptothecin, artesunate, Tween 80, and dimethyl sulfoxide.

[0018] Test weeds: Echinochloa crusgalli, collected from the field and placed indoors to dry naturally before storage.

[0019] Test method: The test was conducted in a greenhouse under natural light conditions. Several plastic pots with holes at the bottom were taken, and appropriate amounts of sandy loam were added. After the soil was completely moistened by infiltration irrigation at the bottom of the pots, 25 seeds of barnyard grass were evenly sown in the soil per pot. After covering with appropriate amount of soil, the soil was moved into the greenhouse for routine cultivation. Soil spraying was carried out 1 day after the weed seeds were sown. The ASS-4 automatic control spray tower was used. The spraying volume was calibrated before the test, and the spraying was carried out according to the test design sequence. The spraying pressure was 275kPa and the spraying volume was 450L / hm2. 2 The distance between the nozzle and the pot was 50 cm. Treatment and blank control were set, and each treatment was repeated 4 times. 21 days after treatment, the fresh weight of the aboveground part of each treatment weed was weighed.

[0020] Calculation method: Fresh weight protection effect (%) = (blank control fresh weight - drug treatment fresh weight) / blank control fresh weight × 100

[0021] The determination of the combined action of the compound was carried out according to the Gowing method in "NY / T1155.7-2006 Pesticide Indoor Bioassay Guidelines Herbicides Part 7: Determination of the Combined Action of Mixtures".

[0022] The calculation formula is: E0=X+Y-XY / 100.

[0023] E represents the actual control effect of each treatment; when (E-E0) <-10%, it is antagonistic, when (E-E0) is between ±10%, it is additive, and when (E-E0) > 10%, it is synergistic.

[0024] Results and Analysis

[0025] The combination of 9-methoxycamptothecin or 10-methoxycamptothecin and artesunate showed a synergistic effect on barnyard grass. When the mass ratio of 9-methoxycamptothecin or 10-methoxycamptothecin to artesunate was 1:10 to 10:1, most ratios had a significant synergistic effect.

[0026] Table 1 Indoor joint action test of herbicidal combination on barnyard grass

[0027]

[0028]

[0029] Table 2 Indoor joint action test of herbicidal combination on barnyard grass

[0030]

[0031] Example 2: Field control effect of herbicidal composition on weeds in rice fields

[0032] Materials and methods Experimental site: rice fields, where rice was growing well and the main weed species included Cyperus difformis, Cyperus spicatus, Echinochloa crusgalli, etc.

[0033] Test reagents:

[0034] Agent 1: 22% suspension, formulation: contains the following ingredients in percentage by weight, artesunate 11%, 10-methoxycamptothecin 11%, Tersperse-22104%, Agrian-7882%, Dispersogen ACP1202%, xanthan gum 0.2%, magnesium aluminum silicate 0.25%, sodium benzoate 0.2%, ethylene glycol 4%, organic bentonite 0.5%, and deionized water to make up 100%.

[0035] Agent 2: 22% suspension, formulation: contains the following ingredients in percentage by weight, artesunate 11%, 10-methoxycamptothecin 11%, Tersperse-22104%, Agrian-7884%, xanthan gum 0.2%, magnesium aluminum silicate 0.25%, sodium benzoate 0.2%, ethylene glycol 4%, organic bentonite 0.5%, and deionized water to make up to 100%.

[0036] Agent 3: 22% suspension, formulation: contains the following ingredients in percentage by weight, artesunate 11%, 10-methoxycamptothecin 11%, Agrian-7884%, Dispersogen ACP1204%, xanthan gum 0.2%, magnesium aluminum silicate 0.25%, sodium benzoate 0.2%, ethylene glycol 4%, organic bentonite 0.5%, and deionized water to make up to 100%.

[0037] Agent 4: 22% suspension, formulation: contains the following ingredients in percentage by weight, artesunate 11%, 9-methoxycamptothecin 11%, Tersperse-22104%, Agrian-7882%, Dispersogen ACP1202%, xanthan gum 0.2%, magnesium aluminum silicate 0.25%, sodium benzoate 0.2%, ethylene glycol 4%, organic bentonite 0.5%, and deionized water to make up 100%.

[0038] Agent 5: 22% suspension, formulation: contains the following ingredients in percentage by weight, artesunate 11%, 9-methoxycamptothecin 11%, Tersperse-22104%, Agrian-7884%, xanthan gum 0.2%, magnesium aluminum silicate 0.25%, sodium benzoate 0.2%, ethylene glycol 4%, organic bentonite 0.5%, and deionized water to make up to 100%.

[0039] Agent 6: 22% suspension, formulation: contains the following ingredients in percentage by weight, artesunate 11%, 9-methoxycamptothecin 11%, Agrian-7884%, Dispersogen ACP1204%, xanthan gum 0.2%, magnesium aluminum silicate 0.25%, sodium benzoate 0.2%, ethylene glycol 4%, organic bentonite 0.5%, and deionized water to make up to 100%.

[0040] Test method: Set up treatment group and control group, repeat 4 times, the area of ​​the plot is 20m 2 Each plot was built with ridges and irrigated separately, and arranged in random blocks. Soil spraying was carried out 3-7 days after rice transplanting, and stem and leaf spraying was carried out with an electric sprayer, with a spray volume of 600L / hm 2 The fresh weight of weeds was investigated 21 days after application. Four random survey points were collected in each plot, with a total area of ​​0.25 m2 at each point. 2 The damage of the pesticide to rice was observed at 21d and 30d.

[0041] Calculation method of protection effect:

[0042] Fresh weight control effect (%) = (fresh weight of weeds in the control area - fresh weight of weeds in the treatment area) / fresh weight of weeds in the control area × 100;

[0043] Results and Analysis

[0044] As shown in Table 3, the dosage of agent 1-6 is 60g ai / 667m 2 It has excellent control effect on rice field weeds such as Cyperus dimorphus, Cyperus spicatus and Echinochloa crus-galli, and field observations show that it is safe for rice; especially the formulations of agent 1 and agent 4 are the best for controlling weeds in rice fields, there are significant differences between agent 1 and agents 2 and 3, and there are significant differences between agent 4 and agents 5 and 6.

[0045] Table 3 Field control effect of herbicides on weeds in rice fields (21 days)

[0046]

[0047] Table 4 Safety survey of herbicides on rice

[0048]

[0049] Example 3: Field control effect of herbicidal composition on dryland crop weeds

[0050] Materials and Methods

[0051] Test site: corn field. Major weed species include barnyard grass, goosegrass, cyperus rotundus, and Bidens pilosa.

[0052] Test reagents:

[0053] Example 1-6

[0054] Test method: Set up treatment group and control group, repeat 4 times, the area of ​​the plot is 20m 2 , arranged in random blocks. Soil spraying was performed 3 days after corn sowing, and stem and leaf spraying was performed with an electric sprayer, with a spray volume of 600 L / hm 2 The fresh weight of weeds was investigated 21 days after application. Four random survey points were collected in each plot, with a total area of ​​0.25 m2 at each point. 2 The damage of the pesticide to corn was observed at 21d and 30d.

[0055] Calculation method of protection effect:

[0056] Fresh weight control effect (%) = (fresh weight of weeds in the control area - fresh weight of weeds in the treatment area) / fresh weight of weeds in the control area × 100;

[0057] Results and Analysis

[0058] From Table 5, we can see that the dosage of agent 1-6 is 60g ai / 667m 2 It has excellent control effect on barnyard grass, goosegrass, cyperus and Bidens pilosa, and is safe for corn in field observation. In particular, the formulations of agent 1 and agent 4 are the best for controlling weeds in rice fields. There are significant differences between agent 1 and agents 2 and 3, and there are significant differences between agent 4 and agents 5 and 6.

[0059] Table 5 Field control effect of herbicides on weeds in corn fields (21 days)

[0060]

[0061]

[0062] Table 6 Safety survey of herbicides on corn

[0063]

[0064] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention, rather than to limit it.

Claims

1. A herbicidal composition comprising artesunate, characterized in that: The active ingredients consist of active ingredient A and active ingredient B, wherein the active ingredient A is 9-methoxycamptothecin or 10-methoxycamptothecin; the active ingredient B is artesunate; and the mass ratio of the active ingredient A to the active ingredient B is 1:10-10:

1.

2. The herbicidal composition according to claim 1, characterized in that The mass ratio of active ingredient A to active ingredient B is 1:5-5:

1.

3. The herbicidal composition according to claim 2, characterized in that The mass ratio of active ingredient A to active ingredient B is 1:5:1:1 or 5:

1.

4. The herbicidal composition according to any one of claims 1 to 3, characterized in that The invention comprises agricultural auxiliary material components, and the total weight percentage of active components is 1-70%.

5. The herbicidal composition according to claim 4, characterized in that The total weight percentage of active ingredients is 5-50%.

6. The herbicidal composition according to claim 4, characterized in that The preparation of the herbicidal composition is a suspension concentrate, a microcapsule suspension concentrate, a water-dispersible granule, or a wettable powder.

7. The herbicidal composition according to claim 6, characterized in that The herbicidal composition is formulated as a suspension concentrate.

8. Use of the herbicidal composition according to any one of claims 1 to 7 for controlling weeds in farmland.

9. The use according to claim 8, characterized in that The weeds are annual weeds.

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