Anti-hair-loss composition and shampoo

Abstract

The invention relates to the technical field of daily chemicals, in particular to an anti-hair-loss composition and shampoo. The composition comprises a soapberry fruit extract, a cacumen biotae extract, a ginseng root extract and a peptide compound. By removing dirt, grease and dead skin cells on the scalp, the anti-hair loss shampoo is beneficial to keeping the scalp clean and preventing hair follicle blockage, so that the hair growth environment is improved. The hair conditioner contains components (such as ginseng and cacumen biotae) capable of promoting blood circulation, and provides more nutrition for hair follicles and promotes hair growth by stimulating blood flow of the hair follicles. The hair conditioner contains plant extract, vitamin B group, amino acid and other components, and can nourish hair follicles, strengthen hair roots and reduce hair loss.

Description

Technical Field

[0001] The invention relates to the technical field of daily chemicals, in particular to an anti-hair loss composition and a shampoo. Background Art

[0002] Sapindus Mukorossi Fruit Extract is a natural plant ingredient extracted from the fruit of the soapberry tree. Sapindus mukorossi, commonly known as "soap fruit" or "wood soapberry", belongs to the Sapindaceae family and is widely distributed in tropical and subtropical regions, such as southern China and India. Its fruit is named after the rich saponin compounds it contains. The main active ingredient in soapberry fruit extract is a natural surfactant with excellent cleaning, foaming, emulsifying and emollient functions. The main saponins include soapberry saponin A, soapberry saponin B, etc.

[0003] Thuja Orientalis Leaf Extract is a natural plant active ingredient extracted from the leaves of Thuja orientalis (also known as Thuja Orientalis, cypress) of the Cupressaceae family. Thuja Orientalis is a common Chinese medicinal material, and its leaves are rich in a variety of active ingredients, with a long history of medicinal and health care. It contains flavonoids: quercetin, kaempferol and its glycosides, etc., which have significant antioxidant and anti-inflammatory activities. Volatile oil: including volatile components such as thujone and camphor, which have antibacterial, sedative and blood circulation promoting effects. Phenolic acid compounds: such as caffeic acid and coumaric acid, have antioxidant and whitening effects.

[0004] Hair loss refers to the abnormal loss of hair, which can be temporary or permanent. Androgenic alopecia (AGA): Also known as "male pattern hair loss" or "female pattern hair loss". It is mainly caused by genetic factors and the action of androgens (DHT, dihydrotestosterone), and manifests as a gradual reduction in hair on the forehead and top of the head. Telogen Effluvium: Due to stress, surgery, childbirth, disease or dietary problems, the hair enters the resting phase prematurely.

[0005] To this end, the present invention provides an anti-hair loss composition and a shampoo. Summary of the invention

[0006] To solve the above technical problems, the present invention provides an anti-hair loss composition, which comprises: soapberry fruit extract, Platycladus orientalis leaf extract, ginseng root extract, and peptide compounds.

[0007] As an embodiment of the present invention, the composition further comprises a stabilizer: sodium methyl cocoyl taurate, polyglyceryl-10 laurate, cocamide MEA, cocamidopropyl betaine, glycerin and dipropylene glycol.

[0008] As an embodiment of the present invention, the peptide compound comprises: acetyl tetrapeptide-5, acetyl tetrapeptide-2, acetyl hexapeptide-8, tetrapeptide-4, palmitoyl tripeptide-8, and arginine / lysine polypeptide.

[0009] As an embodiment of the present invention, the method for extracting the ginseng root extract is:

[0010] S01: Weigh an appropriate amount of ginseng root powder and add 10 times the volume of distilled water; extract at 80°C for 2 hours, and cool the extract to room temperature; filter the extract through filter cloth or filter paper to remove residues; centrifuge the filtrate at 4000rpm for 10 minutes and collect the supernatant;

[0011] S02: gradually add anhydrous ethanol to the supernatant, adjust the ethanol volume fraction to 70% v / v, and stir evenly; let stand for 12 hours, centrifuge to separate the precipitate, collect the supernatant, evaporate the ethanol in the supernatant, and obtain an aqueous extract;

[0012] S03: loading the aqueous phase extract onto a macroporous adsorption resin column D101 type resin; eluting the column with distilled water, and then eluting with 40%-70% ethanol, collecting the ethanol eluate, and concentrating the eluate into a small amount of liquid for later use;

[0013] S04: Mix the precipitate obtained in S02 and a small amount of liquid obtained in S03 to obtain the ginseng root extract.

[0014] As an embodiment of the present invention, the extraction method of the soapberry extract is:

[0015] (1) Weigh the soapberry fruit powder, add 10 times the weight of distilled water, and extract in a constant temperature water bath at 60° C. for 1 hour; filter with filter cloth or filter paper to obtain a clear soapberry extract;

[0016] (2) Dissolve the freeze-dried bacteria in sterile water and inoculate into liquid culture medium (5% glucose, 1% peptone, 0.5% yeast powder, 0.5% polyglutamic acid, 0.1% NaCl, pH 6.5), and culture at 37°C for 12 hours until OD600 = 1.0; dilute the bacterial solution at a ratio of 1:10 for later use;

[0017] (3) Inoculate the activated bacterial solution into the soapberry extract at a volume ratio of 5%; temperature: 37° C., shaking speed: 120 rpm; time: 48 hours; pH: initially adjusted to 5.5 with lactic acid;

[0018] (4) After the fermentation is completed, centrifuge at 4000 rpm for 10 minutes to separate the supernatant; concentrate the fermentation broth to 1 / 3 of the original volume using a vacuum concentrator and sterilize at 121°C for 15 minutes; filter using a 0.22 μm filter membrane to remove microorganisms and residual impurities.

[0019] As an embodiment of the present invention, the fermentation strain is selected from: one or more of lactic acid bacteria, yeast, and Bacillus subtilis.

[0020] The invention provides a shampoo comprising the anti-hair loss composition.

[0021] As an embodiment of the present invention, the raw materials for its preparation include: sodium laureth sulfate, cocamidopropyl betaine, disodium laureth sulfosuccinate, and disodium cocoamphodiacetate.

[0022] As an embodiment of the present invention, the raw materials for preparation thereof further include: cocamide MEA, polydimethylsiloxane alcohol, TEA dodecylbenzene sulfonate, and laureth-23.

[0023] As an embodiment of the present invention, the raw materials for preparation thereof further include: ginger (ZINGIBER OFFICINALE) root extract, scutellaria baicalensis (SCUTELLARIABAICALENSIS) root extract, rosemary (ROSMARINUS OFFICINALIS) leaf extract, and chamomile (CHAMOMILLA RECUTITA) flower extract.

[0024] By adopting the above technical solution, the present invention has the following beneficial effects:

[0025] 1. Anti-hair loss shampoo helps keep the scalp clean and prevents hair follicles from clogging by removing dirt, oil and dead skin cells from the scalp, thereby improving the environment for hair growth.

[0026] 2. Contains ingredients that can promote blood circulation (such as ginseng, cypress leaves, etc.), which stimulate blood flow to hair follicles, provide more nutrients to hair follicles, and promote hair growth.

[0027] 3. Contains plant extracts, B vitamins, amino acids and other ingredients, which can nourish hair follicles, strengthen hair roots and reduce hair loss.

[0028] 4. By supplementing the nutrients needed by hair, it improves the strength and toughness of hair and reduces hair loss caused by fragility.

[0029] 5. The ingredients in anti-hair loss shampoo help balance the oil secretion of the scalp, prevent excessive oil from causing clogging of hair follicles, and reduce the resulting hair loss.

[0030] 6. By promoting the health of hair follicles, anti-hair loss shampoo helps to prolong the anagen phase (growth phase) and reduce the amount of hair that enters the resting phase or shedding phase. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] In order to more clearly illustrate the specific implementation methods of the present invention or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0032] Figure 1 This is a photo of the scalp before using the product of Example 1.

[0033] Figure 2 This is a photo of the scalp after using the product of Example 1. DETAILED DESCRIPTION

[0034] The technical solution of the present invention will be described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0035] The present invention is further explained below in conjunction with specific implementation modes.

[0036] Example 1

[0037] This embodiment provides a shampoo, and the raw materials for its preparation include, by weight:

[0038] 0.03953 parts of 1,2-hexanediol, 0.05 parts of 1,3-propylene glycol, 0.004 parts of C12-15 polyether-3, 0.1 parts of disodium EDTA, 0.623924 parts of sodium benzoate, 0.15 parts of piroctone olamine salt, 0.04 parts of acrylamidopropyltrimonium chloride / acrylamide copolymer, 4.9 parts of Thuja Orientalis leaf extract, 0.0208 parts of butylene glycol, 0.00605 parts of p-hydroxyacetophenone, 0.15 parts of panthenol, 0.014253 parts of glycerin, 0.3295 parts of guar hydroxypropyltrimonium chloride, 0.8 parts of scutellaria baicalensis root extract, 0.05 parts of hexylene glycol, 0.035 parts of sodium methyl cocoyl taurate, 0.035 parts of ginger OFFICINALE root extract 0.0175 parts, caramel color 0.05 parts, polydimethylsiloxane 0.98 parts, polydimethylsiloxane 1.2 parts, polyglyceryl-10 laurate 0.35 parts, sodium chloride 0.44 parts, rosemary (ROSMARINUS OFFICINALIS) leaf extract 0.05 parts, matricaria (CHAMOMILLARECUTITA) flower extract 0.5 parts, citric acid 0.2 parts, hydrogenated castor oil 0.07 parts, hydrogenated starch hydrolyzate 0.4 parts, ginseng (PANAX GINSENG) root extract 5.5 parts, dodecylbenzenesulfonate TEA salt 0.0375 parts, dipropylene glycol 3.2 parts, soapberry (SAPINDUS MUKOROSSI) fruit extract 3.5 parts, caprylyl glycol 0.000002 parts, cocamide MEA 1.535 parts, cocamidopropyl betaine 1.205 parts, disodium cocoamphodiacetate 0.69 parts, ethylhexylglycerin 0.003 parts, polypeptide compound (acetyl tetrapeptide-5 0.004 parts, acetyl tetrapeptide-2 0.004 parts, acetyl hexapeptide-8 0.004 parts, tetrapeptide-4 0.004 parts, palmitoyl tripeptide-8 0.004 parts, arginine / lysine polypeptide 0.0043 parts), sodium isostearyl lactylate 0.2 parts, laureth-23 0.0375 parts, disodium laureth sulfosuccinate 0.6 parts, sodium laureth sulfate 11.2 parts, (daily use) flavor 0.4 parts, water is added to 100 parts.

[0039] The method of extracting the ginseng root extract:

[0040] S01: Weigh an appropriate amount of ginseng root powder and add 10 times the volume of distilled water; extract at 80°C for 2 hours, and cool the extract to room temperature; filter the extract through filter cloth or filter paper to remove residues; centrifuge the filtrate at 4000rpm for 10 minutes and collect the supernatant;

[0041] S02: gradually add anhydrous ethanol to the supernatant, the ethanol volume fraction is 70% v / v, and stir evenly; let it stand for 12 hours, centrifuge to separate the precipitate, collect the supernatant, evaporate the ethanol in the supernatant, and obtain an aqueous phase extract;

[0042] S03: loading the aqueous phase extract onto a macroporous adsorption resin column D101 type resin; eluting the column with distilled water, and then eluting with 40%-70% ethanol, collecting the ethanol eluate, and concentrating the eluate into a small amount of liquid for later use;

[0043] S04: Mix the precipitate obtained in S02 and a small amount of liquid obtained in S03 to obtain the ginseng root extract.

[0044] The extraction method of the soapberry extract:

[0045] (1) Weigh the soapberry fruit powder, add 10 times the weight of distilled water, and extract in a constant temperature water bath at 60° C. for 1 hour; filter with filter cloth or filter paper to obtain a clear soapberry extract;

[0046] (2) Dissolve the freeze-dried bacteria in sterile water and inoculate into liquid culture medium (5% glucose, 1% peptone, 0.5% yeast powder, 0.5% polyglutamic acid, 0.1% NaCl, pH 6.5), and culture at 37°C for 12 hours until OD600 = 1.0; dilute the bacterial solution at a ratio of 1:10 for later use;

[0047] (3) Inoculate the activated bacterial solution into the soapberry extract at a volume ratio of 5%; temperature: 37° C., shaking speed: 120 rpm; time: 48 hours; pH: initially adjusted to 5.5 with lactic acid;

[0048] (4) After the fermentation is completed, centrifuge at 4000 rpm for 10 minutes to separate the supernatant; concentrate the fermentation broth to 1 / 3 of the original volume using a vacuum concentrator and sterilize at 121°C for 15 minutes; filter using a 0.22 μm filter membrane to remove microorganisms and residual impurities.

[0049] The fermentation strain comprises Lactiplantibacillus plantarum 21793 and Bacillus subtilis 10732, the inoculum ratio is 1:1.

[0050] In this embodiment, the preparation method of the shampoo is as follows:

[0051] (1) Clean and disinfect all production equipment and utensils used.

[0052] (2) Add 1 part by mass of water to piroctone ethanolamine salt and mix and soak for 40 minutes in advance to completely disperse and set aside.

[0053] (3) Add 1 / 4 mass part of deionized water into the main pot, start homogenization (2000-2800rpm), add guar hydroxypropyltrimethylammonium chloride and acrylamidopropyltrimethylammonium chloride / acrylamide copolymer in sequence, add 1 / 4 mass part of deionized water after homogenization and dispersion, stir (300-600rpm) and heat to (80-85)°C, start homogenization (2000-2800rpm) and add half mass part of cocamidopropyl betaine, half mass part of sodium benzoate, half mass part of cocamide MEA, disodium EDTA, acetyl hexapeptide-8, tetrapeptide-4, palmitoyl tripeptide-8, glycerol, dipropylene glycol, homogenize and disperse, and keep warm and stir for (20-25)min. Check that the material is completely dissolved and then start to cool down.

[0054] (4) Cool down to (75-70)°C, add hydrogenated castor oil, sodium isostearyl lactylate, citric acid, sodium methyl cocoyl taurate, polyglyceryl-10 laurate, remaining cocamide MEA, remaining cocamidopropyl betaine, half the mass fraction of 1,2-hexanediol, half the mass fraction of p-hydroxyacetophenone, sodium laureth sulfate, disodium laureth sulfosuccinate, and pretreated piroctone olamine salt, and continue to cool down after proper homogenization and dissolution. Add all the remaining ingredients at (48-45)°C, stir evenly (low speed homogenization can be used to aid dispersion), take samples for testing, and filter out the material with a 100-mesh filter cloth after passing the test.

[0055] Example 2

[0056] This embodiment provides a shampoo, and the raw materials for its preparation include, by weight:

[0057] 0.03953 parts of 1,2-hexanediol, 0.05 parts of 1,3-propylene glycol, 0.004 parts of C12-15 polyether-3, 0.1 parts of disodium EDTA, 0.623924 parts of sodium benzoate, 0.15 parts of piroctone olamine salt, 0.04 parts of acrylamidopropyltrimonium chloride / acrylamide copolymer, 4.9 parts of Thuja Orientalis leaf extract, 0.0208 parts of butylene glycol, 0.00605 parts of p-hydroxyacetophenone, 0.15 parts of panthenol, 0.014253 parts of glycerin, 0.3295 parts of guar hydroxypropyltrimonium chloride, 0.8 parts of scutellaria baicalensis root extract, 0.05 parts of hexylene glycol, 0.035 parts of sodium methyl cocoyl taurate, 0.035 parts of ginger OFFICINALE) root extract 0.0175 parts, caramel color 0.05 parts, polydimethylsiloxane 0.98 parts, polydimethylsiloxane 1.2 parts, polyglyceryl-10 laurate 0.35 parts, sodium chloride 0.44 parts, rosemary (ROSMARINUS OFFICINALIS) leaf extract 0.05 parts, matricaria (CHAMOMILLA RECUTITA) flower extract 0.5 parts, citric acid 0.2 parts, hydrogenated castor oil 0.07 parts, hydrogenated starch hydrolyzate 0.4 parts, ginseng (PANAX GINSENG) root extract 5.5 parts, dodecylbenzenesulfonate TEA salt 0.0375 parts, dipropylene glycol 3.2 parts, soapberry (SAPINDUS MUKOROSSI) fruit extract 3.5 parts, caprylyl glycol 0.000002 parts, cocamide MEA 1.535 parts, cocamidopropyl betaine 1.205 parts, disodium cocoamphodiacetate 0.69 parts, ethylhexylglycerin 0.003 parts, polypeptide compound (acetyl tetrapeptide-5 0.004 parts, acetyl tetrapeptide-2 0.004 parts, acetyl hexapeptide-8 0.004 parts, tetrapeptide-4 0.004 parts, palmitoyl tripeptide-8 0.004 parts, arginine / lysine polypeptide 0.0043 parts), sodium isostearyl lactylate 0.2 parts, laureth-23 0.0375 parts, disodium laureth sulfosuccinate 0.6 parts, sodium laureth sulfate 11.2 parts, (daily use) flavor 0.4 parts, water is added to 100 parts.

[0058] The ginseng root extract is commercially available from water extraction.

[0059] The soapberry extract is commercially available through water extraction.

[0060] In this embodiment, the preparation method of the shampoo is as follows:

[0061] (1) Clean and disinfect all production equipment and utensils used.

[0062] (2) Add 1 part by mass of water to piroctone ethanolamine salt and mix and soak for 40 minutes in advance to completely disperse and set aside.

[0063] (3) Add 1 / 4 mass part of deionized water into the main pot, start homogenization (2000-2800rpm), add guar hydroxypropyltrimethylammonium chloride and acrylamidopropyltrimethylammonium chloride / acrylamide copolymer in sequence, add 1 / 4 mass part of deionized water after homogenization and dispersion, stir (300-600rpm) and heat to (80-85)°C, start homogenization (2000-2800rpm) and add half mass part of cocamidopropyl betaine, half mass part of sodium benzoate, half mass part of cocamide MEA, disodium EDTA, acetyl hexapeptide-8, tetrapeptide-4, palmitoyl tripeptide-8, glycerol, dipropylene glycol, homogenize and disperse, and keep warm and stir for (20-25)min. Check that the material is completely dissolved and then start to cool down.

[0064] (4) Cool down to (75-70)°C, add hydrogenated castor oil, sodium isostearyl lactylate, citric acid, sodium methyl cocoyl taurate, polyglyceryl-10 laurate, remaining cocamide MEA, remaining cocamidopropyl betaine, half the mass fraction of 1,2-hexanediol, half the mass fraction of p-hydroxyacetophenone, sodium laureth sulfate, disodium laureth sulfosuccinate, and pretreated piroctone olamine salt, and continue to cool down after proper homogenization and dissolution. Add all the remaining ingredients at (48-45)°C, stir evenly (low speed homogenization can be used to aid dispersion), take samples for testing, and filter out the material with a 100-mesh filter cloth after passing the test.

[0065] Example 3

[0066] This embodiment provides a shampoo, and the raw materials for its preparation include, by weight:

[0067] 0.03953 parts of 1,2-hexanediol, 0.05 parts of 1,3-propylene glycol, 0.004 parts of C12-15 polyether-3, 0.1 parts of disodium EDTA, 0.623924 parts of sodium benzoate, 0.15 parts of piroctone olamine, 4.9 parts of Thuja Orientalis leaf extract, 0.0208 parts of butylene glycol, 0.00605 parts of p-hydroxyacetophenone, 0.15 parts of panthenol, 0.014253 parts of glycerin, 0.3295 parts of guar hydroxypropyltrimonium chloride, 0.8 parts of scutellaria baicalensis root extract, 0.05 parts of hexylene glycol, 0.075 parts of sodium methyl cocoyl taurate, 0.075 parts of ginger, 0.08 parts of scutellaria baicalensis root extract, 0.05 parts of hexylene glycol, 0.075 parts of sodium methyl cocoyl taurate ...0605 parts of p-hydroxyacetophenone, 0.15 parts of panthenol, 0.014253 parts of glycerin, 0.00605 parts of p-hydroxyacetophenone, 0.15 parts of panthenol, 0.00605 parts of p-hydroxyacetophenone, 0.15 parts of panthenol, 0.014253 parts of glycerin, 0.00605 parts of p-hydroxyacetophenone, 0.00605 parts of p-hydroxyacetophen OFFICINALE root extract 0.0175 parts, caramel color 0.05 parts, polydimethylsiloxane 0.98 parts, polydimethylsiloxane 1.2 parts, polyglyceryl-10 laurate 0.35 parts, sodium chloride 0.44 parts, rosemary (ROSMARINUS OFFICINALIS) leaf extract 0.05 parts, matricaria (CHAMOMILLARECUTITA) flower extract 0.5 parts, citric acid 0.2 parts, hydrogenated castor oil 0.07 parts, hydrogenated starch hydrolyzate 0.4 parts, ginseng (PANAX GINSENG) root extract 5.5 parts, dodecylbenzenesulfonate TEA salt 0.0375 parts, dipropylene glycol 3.2 parts, soapberry (SAPINDUS MUKOROSSI) fruit extract 3.5 parts, caprylyl glycol 0.000002 parts, disodium cocoamphodiacetate 3.43 parts, ethylhexylglycerin 0.003 parts, polypeptide compound (acetyl tetrapeptide-5 0.004 parts, acetyl tetrapeptide-2 0.004 parts, acetyl hexapeptide-8 0.004 parts, tetrapeptide-4 0.004 parts, palmitoyl tripeptide-8 0.004 parts, arginine / lysine polypeptide 0.0043 parts), sodium isostearyl lactylate 0.2 parts, laureth-23 0.0375 parts, disodium laureth sulfosuccinate 0.6 parts, sodium laureth sulfate 11.2 parts, (daily use) flavor 0.4 parts, water is added to 100 parts.

[0068] The method of extracting the ginseng root extract:

[0069] S01: Weigh an appropriate amount of ginseng root powder and add 10 times the volume of distilled water; extract at 80°C for 2 hours, and cool the extract to room temperature; filter the extract through filter cloth or filter paper to remove residues; centrifuge the filtrate at 4000rpm for 10 minutes and collect the supernatant;

[0070] S02: gradually add anhydrous ethanol to the supernatant, the ethanol volume fraction is 70% v / v, and stir evenly; let it stand for 12 hours, centrifuge to separate the precipitate, collect the supernatant, evaporate the ethanol in the supernatant, and obtain an aqueous phase extract;

[0071] S03: loading the aqueous phase extract onto a macroporous adsorption resin column D101 type resin; eluting the column with distilled water, and then eluting with 40%-70% ethanol, collecting the ethanol eluate, and concentrating the eluate into a small amount of liquid for later use;

[0072] S04: Mix the precipitate obtained in S02 and a small amount of liquid obtained in S03 to obtain the ginseng root extract.

[0073] The extraction method of the soapberry extract:

[0074] (1) Weigh the soapberry fruit powder, add 10 times the weight of distilled water, and extract in a constant temperature water bath at 60° C. for 1 hour; filter with filter cloth or filter paper to obtain a clear soapberry extract;

[0075] (2) Dissolve the freeze-dried bacteria in sterile water and inoculate into liquid culture medium (5% glucose, 1% peptone, 0.5% yeast powder, 0.5% polyglutamic acid, 0.1% NaCl, pH 6.5), and culture at 37°C for 12 hours until OD600 = 1.0; dilute the bacterial solution at a ratio of 1:10 for later use;

[0076] (3) Inoculate the activated bacterial solution into the soapberry extract at a volume ratio of 5%; temperature: 37° C., shaking speed: 120 rpm; time: 48 hours; pH: initially adjusted to 5.5 with lactic acid;

[0077] (4) After the fermentation is completed, centrifuge at 4000 rpm for 10 minutes to separate the supernatant; concentrate the fermentation broth to 1 / 3 of the original volume using a vacuum concentrator and sterilize at 121°C for 15 minutes; filter using a 0.22 μm filter membrane to remove microorganisms and residual impurities.

[0078] The fermentation strain comprises Lactiplantibacillus plantarum 21793 and Bacillus subtilis 10732, the inoculum ratio is 1:1.

[0079] In this embodiment, the preparation method of the shampoo is as follows:

[0080] (1) Clean and disinfect all production equipment and utensils used.

[0081] (2) Add 1 part by mass of water to piroctone ethanolamine salt and mix and soak for 40 minutes in advance to completely disperse and set aside.

[0082] (3) Add 1 / 4 mass part of deionized water into the main pot, start homogenization (2000-2800rpm), add guar hydroxypropyltrimethylammonium chloride and acrylamidopropyltrimethylammonium chloride / acrylamide copolymer in sequence, add 1 / 4 mass part of deionized water after homogenization and dispersion, stir (300-600rpm) and heat to (80-85)°C, start homogenization (2000-2800rpm) and add half mass part of cocamidopropyl betaine, half mass part of sodium benzoate, half mass part of cocamide MEA, disodium EDTA, acetyl hexapeptide-8, tetrapeptide-4, palmitoyl tripeptide-8, glycerol, dipropylene glycol, homogenize and disperse, and keep warm and stir for (20-25)min. Check that the material is completely dissolved and then start to cool down.

[0083] (4) Cool down to (75-70)°C, add hydrogenated castor oil, sodium isostearyl lactylate, citric acid, sodium methyl cocoyl taurate, polyglyceryl-10 laurate, remaining cocamide MEA, remaining cocamidopropyl betaine, half the mass fraction of 1,2-hexanediol, half the mass fraction of p-hydroxyacetophenone, sodium laureth sulfate, disodium laureth sulfosuccinate, and pretreated piroctone olamine salt, and continue to cool down after proper homogenization and dissolution. Add all the remaining ingredients at (48-45)°C, stir evenly (low speed homogenization can be used to aid dispersion), take samples for testing, and filter out the material with a 100-mesh filter cloth after passing the test.

[0084] Example 4

[0085] This embodiment provides a shampoo, and the raw materials for its preparation include, by weight:

[0086] 0.03953 parts of 1,2-hexanediol, 0.05 parts of 1,3-propylene glycol, 0.004 parts of C12-15 polyether-3, 0.1 parts of disodium EDTA, 0.623924 parts of sodium benzoate, 0.15 parts of piroctone olamine salt, 0.04 parts of acrylamidopropyltrimonium chloride / acrylamide copolymer, 4.9 parts of Thujaorientalis leaf extract, 0.0208 parts of butylene glycol, 0.00605 parts of p-hydroxyacetophenone, 0.15 parts of panthenol, 0.014253 parts of glycerin, 0.3295 parts of guar hydroxypropyltrimonium chloride, 0.8 parts of scutellaria baicalensis root extract, 0.05 parts of hexylene glycol, 0.035 parts of sodium methyl cocoyl taurate, 0.035 parts of ginger OFFICINALE) root extract 0.0175 parts, caramel color 0.05 parts, polydimethylsiloxane 0.98 parts, polydimethylsiloxane 1.2 parts, polyglyceryl-10 laurate 0.35 parts, sodium chloride 0.44 parts, rosemary (ROSMARINUSOFFICINALIS) leaf extract 0.05 parts, matricaria (CHAMOMILLA RECUTITA) flower extract 0.5 parts, citric acid 0.2 parts, hydrogenated castor oil 0.07 parts, hydrogenated starch hydrolyzate 0.4 parts, ginseng (PANAX GINSENG) root extract 5.5 parts, dodecylbenzenesulfonate TEA salt 0.0375 parts, dipropylene glycol 3.2 parts, sodium lauroyl glutamate 3.5 parts, caprylyl glycol 0.000002 parts, cocamide MEA 1.535 parts, 1.205 parts of cocamidopropyl betaine, 0.69 parts of disodium cocoamphodiacetate, 0.003 parts of ethylhexylglycerin, polypeptide compound (0.004 parts of acetyl tetrapeptide-5, 0.004 parts of acetyl tetrapeptide-2, 0.004 parts of acetyl hexapeptide-8, 0.004 parts of tetrapeptide-4, 0.004 parts of palmitoyl tripeptide-8, 0.0043 parts of arginine / lysine polypeptide), 0.2 parts of sodium isostearyl lactylate, 0.0375 parts of laureth-23, 0.6 parts of disodium laureth sulfosuccinate, 11.2 parts of sodium laureth sulfate, 0.4 parts of (daily use) flavor, and water is added to 100 parts.

[0087] The method of extracting the ginseng root extract:

[0088] S01: Weigh an appropriate amount of ginseng root powder and add 10 times the volume of distilled water; extract at 80°C for 2 hours, and cool the extract to room temperature; filter the extract through filter cloth or filter paper to remove residues; centrifuge the filtrate at 4000rpm for 10 minutes and collect the supernatant;

[0089] S02: gradually add anhydrous ethanol to the supernatant, the ethanol volume fraction is 70% v / v, and stir evenly; let it stand for 12 hours, centrifuge to separate the precipitate, collect the supernatant, evaporate the ethanol in the supernatant, and obtain an aqueous phase extract;

[0090] S03: loading the aqueous phase extract onto a macroporous adsorption resin column D101 type resin; eluting the column with distilled water, and then eluting with 40%-70% ethanol, collecting the ethanol eluate, and concentrating the eluate into a small amount of liquid for later use;

[0091] S04: Mix the precipitate obtained in S02 and a small amount of liquid obtained in S03 to obtain the ginseng root extract.

[0092] In this embodiment, the preparation method of the shampoo is as follows:

[0093] (1) Clean and disinfect all production equipment and utensils used.

[0094] (2) Add 1 part by mass of water to piroctone ethanolamine salt and mix and soak for 40 minutes in advance to completely disperse and set aside.

[0095] (3) Add 1 / 4 mass part of deionized water into the main pot, start homogenization (2000-2800rpm), add guar hydroxypropyltrimethylammonium chloride and acrylamidopropyltrimethylammonium chloride / acrylamide copolymer in sequence, add 1 / 4 mass part of deionized water after homogenization and dispersion, stir (300-600rpm) and heat to (80-85)°C, start homogenization (2000-2800rpm) and add half mass part of cocamidopropyl betaine, half mass part of sodium benzoate, half mass part of cocamide MEA, disodium EDTA, acetyl hexapeptide-8, tetrapeptide-4, palmitoyl tripeptide-8, glycerol, dipropylene glycol, homogenize and disperse, and keep warm and stir for (20-25)min. Check that the material is completely dissolved and then start to cool down.

[0096] (4) Cool down to (75-70)°C, add hydrogenated castor oil, sodium isostearyl lactylate, citric acid, sodium methyl cocoyl taurate, polyglyceryl-10 laurate, remaining cocamide MEA, remaining cocamidopropyl betaine, half the mass fraction of 1,2-hexanediol, half the mass fraction of p-hydroxyacetophenone, sodium laureth sulfate, disodium laureth sulfosuccinate, and pretreated piroctone olamine salt, and continue to cool down after proper homogenization and dissolution. Add all the remaining ingredients at (48-45)°C, stir evenly (low speed homogenization can be used to aid dispersion), take samples for testing, and filter out the material with a 100-mesh filter cloth after passing the test.

[0097] Example 5

[0098] This embodiment provides a shampoo, and the raw materials for its preparation include, by weight:

[0099] 0.03953 parts of 1,2-hexanediol, 0.05 parts of 1,3-propylene glycol, 0.004 parts of C12-15 polyether-3, 0.1 parts of disodium EDTA, 0.623924 parts of sodium benzoate, 0.15 parts of piroctone olamine salt, 0.04 parts of acrylamidopropyltrimonium chloride / acrylamide copolymer, 4.9 parts of Thuja Orientalis leaf extract, 0.0208 parts of butylene glycol, 0.00605 parts of p-hydroxyacetophenone, 0.15 parts of panthenol, 0.014253 parts of glycerin, 0.3295 parts of guar hydroxypropyltrimonium chloride, 0.8 parts of scutellaria baicalensis root extract, 0.05 parts of hexylene glycol, 0.035 parts of sodium methyl cocoyl taurate, 0.035 parts of ginger OFFICINALE root extract 0.0175 parts, caramel color 0.05 parts, polydimethylsiloxane 0.98 parts, polydimethylsiloxane 1.2 parts, polyglyceryl-10 laurate 0.35 parts, sodium chloride 0.44 parts, rosemary (ROSMARINUS OFFICINALIS) leaf extract 0.05 parts, matricaria (CHAMOMILLA RECUTITA) flower extract 0.5 parts, citric acid 0.2 parts, hydrogenated castor oil 0.07 parts, hydrogenated starch hydrolyzate 0.4 parts, ginseng (PANAX GINSENG) root extract 5.5 parts, dodecylbenzenesulfonate TEA salt 0.0375 parts, dipropylene glycol 3.2 parts, soapberry (SAPINDUS MUKOROSSI) fruit extract 3.5 parts, caprylyl glycol 0.000002 parts, cocamide MEA 1.535 parts, cocamidopropyl betaine 1.205 parts, disodium cocoamphodiacetate 0.69 parts, ethylhexylglycerin 0.003 parts, polypeptide compound (acetyl tetrapeptide-5 0.004 parts, acetyl tetrapeptide-2 0.004 parts, acetyl hexapeptide-8 0.004 parts, tetrapeptide-4 0.004 parts, palmitoyl tripeptide-8 0.004 parts, arginine / lysine polypeptide 0.0043 parts), sodium isostearyl lactylate 0.2 parts, laureth-23 0.0375 parts, disodium laureth sulfosuccinate 0.6 parts, sodium laureth sulfate 11.2 parts, (daily use) flavor 0.4 parts, water is added to 100 parts.

[0100] The method of extracting the ginseng root extract:

[0101] S01: Weigh an appropriate amount of ginseng root powder and add 10 times the volume of distilled water; extract at 80°C for 2 hours, and cool the extract to room temperature; filter the extract through filter cloth or filter paper to remove residues; centrifuge the filtrate at 4000rpm for 10 minutes and collect the supernatant;

[0102] S02: gradually add anhydrous ethanol to the supernatant, the ethanol volume fraction is 70% v / v, and stir evenly; let it stand for 12 hours, centrifuge to separate the precipitate, collect the supernatant, evaporate the ethanol in the supernatant, and obtain an aqueous phase extract;

[0103] S03: loading the aqueous phase extract onto a macroporous adsorption resin column D101 type resin; eluting the column with distilled water, and then eluting with 40%-70% ethanol, collecting the ethanol eluate, and concentrating the eluate into a small amount of liquid for later use;

[0104] S04: Mix the precipitate obtained in S02 and a small amount of liquid obtained in S03 to obtain the ginseng root extract.

[0105] The extraction method of the soapberry extract:

[0106] (1) Weigh the soapberry fruit powder, add 10 times the weight of distilled water, and extract in a constant temperature water bath at 60° C. for 1 hour; filter with filter cloth or filter paper to obtain a clear soapberry extract;

[0107] (2) Dissolve the freeze-dried bacteria in sterile water and inoculate into liquid culture medium (5% glucose, 1% peptone, 0.5% yeast powder, 0.5% polyglutamic acid, 0.1% NaCl, pH 6.5), and culture at 37°C for 12 hours until OD600 = 1.0; dilute the bacterial solution at a ratio of 1:10 for later use;

[0108] (3) Inoculate the activated bacterial solution into the soapberry extract at a volume ratio of 5%; temperature: 37° C., shaking speed: 120 rpm; time: 48 hours; pH: initially adjusted to 5.5 with lactic acid;

[0109] (4) After the fermentation is completed, centrifuge at 4000 rpm for 10 minutes to separate the supernatant; concentrate the fermentation broth to 1 / 3 of the original volume using a vacuum concentrator and sterilize at 121°C for 15 minutes; filter using a 0.22 μm filter membrane to remove microorganisms and residual impurities.

[0110] The fermentation strain comprises Lactiplantibacillus plantarum 21793 and Bacillus subtilis 10732, the inoculum ratio is 1:1.

[0111] In this embodiment, the preparation method of the shampoo is as follows:

[0112] (1) Clean and disinfect all production equipment and utensils used.

[0113] (2) Add 1 part by mass of water to piroctone ethanolamine salt and mix and soak for 40 minutes in advance to completely disperse and set aside.

[0114] (3) Add 1 / 4 mass part of deionized water into the main pot, start homogenization (2000-2800rpm), add guar hydroxypropyltrimethylammonium chloride and acrylamidopropyltrimethylammonium chloride / acrylamide copolymer in sequence, add 1 / 4 mass part of deionized water after homogenization and dispersion, stir (300-600rpm) and heat to (80-85)°C, start homogenization (2000-2800rpm) and add half mass part of cocamidopropyl betaine, half mass part of sodium benzoate, half mass part of cocamide MEA, disodium EDTA, glycerin, dipropylene glycol, keep warm and stir for (20-25)min after homogenization and dispersion, check that the material is completely dissolved and then start to cool down.

[0115] (4) Cool down to (75-70)°C, add hydrogenated castor oil, sodium isostearyl lactylate, citric acid, sodium methyl cocoyl taurate, polyglyceryl-10 laurate, remaining cocamide MEA, remaining cocamidopropyl betaine, half the mass fraction of 1,2-hexanediol, half the mass fraction of p-hydroxyacetophenone, sodium laureth sulfate, disodium laureth sulfosuccinate, and pretreated piroctone olamine salt, and continue to cool down after proper homogenization and dissolution. Add all the remaining ingredients at (48-45)°C, stir evenly (low speed homogenization can be used to aid dispersion), take samples for testing, and filter out the material with a 100-mesh filter cloth after passing the test.

[0116] Example 6

[0117] This embodiment provides a shampoo, and the raw materials for its preparation include, by weight:

[0118] 0.03953 parts of 1,2-hexanediol, 0.05 parts of 1,3-propylene glycol, 0.004 parts of C12-15 polyether-3, 0.1 parts of disodium EDTA, 0.623924 parts of sodium benzoate, 0.15 parts of piroctone olamine salt, 0.04 parts of acrylamidopropyltrimonium chloride / acrylamide copolymer, 4.9 parts of Thuja Orientalis leaf extract, 0.0208 parts of butylene glycol, 0.00605 parts of p-hydroxyacetophenone, 0.15 parts of panthenol, 0.014253 parts of glycerin, 0.3295 parts of guar hydroxypropyltrimonium chloride, 0.8 parts of scutellaria baicalensis root extract, 0.05 parts of hexylene glycol, 0.035 parts of sodium methyl cocoyl taurate, 0.035 parts of ginger OFFICINALE root extract 0.0175 parts, caramel color 0.05 parts, polydimethylsiloxane 0.98 parts, polydimethylsiloxane 1.2 parts, polyglyceryl-10 laurate 0.35 parts, sodium chloride 0.44 parts, rosemary (ROSMARINUS OFFICINALIS) leaf extract 0.05 parts, matricaria (CHAMOMILLARECUTITA) flower extract 0.5 parts, citric acid 0.2 parts, hydrogenated castor oil 0.07 parts, hydrogenated starch hydrolyzate 0.4 parts, ginseng (PANAX GINSENG) root extract 5.5 parts, dodecylbenzenesulfonate TEA salt 0.0375 parts, dipropylene glycol 3.2 parts, soapberry (SAPINDUS MUKOROSSI) fruit extract 3.5 parts, caprylyl glycol 0.000002 parts, cocamide MEA 1.535 parts, cocamidopropyl betaine 1.205 parts, disodium cocoamphodiacetate 0.69 parts, ethylhexylglycerin 0.003 parts, polypeptide compound (acetyl tetrapeptide-5 0.004 parts, acetyl tetrapeptide-2 0.004 parts, acetyl hexapeptide-8 0.004 parts, tetrapeptide-4 0.004 parts, palmitoyl tripeptide-8 0.004 parts, arginine / lysine polypeptide 0.0043 parts), sodium isostearyl lactylate 0.2 parts, laureth-23 0.0375 parts, disodium laureth sulfosuccinate 0.6 parts, sodium laureth sulfate 11.2 parts, (daily use) flavor 0.4 parts, water is added to 100 parts.

[0119] The method of extracting the ginseng root extract:

[0120] S01: Weigh an appropriate amount of ginseng root powder and add 10 times the volume of distilled water; extract at 80°C for 2 hours, and cool the extract to room temperature; filter the extract through filter cloth or filter paper to remove residues; centrifuge the filtrate at 4000rpm for 10 minutes and collect the supernatant;

[0121] S02: gradually add anhydrous ethanol to the supernatant, the ethanol volume fraction is 70% v / v, and stir evenly; let it stand for 12 hours, centrifuge to separate the precipitate, collect the supernatant, evaporate the ethanol in the supernatant, and obtain an aqueous phase extract;

[0122] S03: loading the aqueous phase extract onto a macroporous adsorption resin column D101 type resin; eluting the column with distilled water, and then eluting with 40%-70% ethanol, collecting the ethanol eluate, and concentrating the eluate into a small amount of liquid for later use;

[0123] S04: Mix the precipitate obtained in S02 and a small amount of liquid obtained in S03 to obtain the ginseng root extract.

[0124] The extraction method of the soapberry extract:

[0125] (1) Weigh the soapberry fruit powder, add 10 times the weight of distilled water, and extract in a constant temperature water bath at 60° C. for 1 hour; filter with filter cloth or filter paper to obtain a clear soapberry extract;

[0126] (2) Dissolve the freeze-dried bacteria in sterile water and inoculate into liquid culture medium (5% glucose, 1% peptone, 0.5% yeast powder, 0.5% polyglutamic acid, 0.1% NaCl, pH 6.5), and culture at 37°C for 12 hours until OD600 = 1.0; dilute the bacterial solution at a ratio of 1:10 for later use;

[0127] (3) Inoculate the activated bacterial solution into the soapberry extract at a volume ratio of 5%; temperature: 37° C., shaking speed: 120 rpm; time: 48 hours; pH: initially adjusted to 5.5 with lactic acid;

[0128] (4) After the fermentation is completed, centrifuge at 4000 rpm for 10 minutes to separate the supernatant; concentrate the fermentation broth to 1 / 3 of the original volume using a vacuum concentrator and sterilize at 121°C for 15 minutes; filter using a 0.22 μm filter membrane to remove microorganisms and residual impurities.

[0129] The fermentation strain comprises Lactiplantibacillus plantarum 21793 and Bacillus subtilis 10732, the inoculum ratio is 1:1.

[0130] In this embodiment, the preparation method of the shampoo is as follows:

[0131] (1) Clean and disinfect all production equipment and utensils used.

[0132] (2) Add 1 part by mass of water to piroctone ethanolamine salt and mix and soak for 40 minutes in advance to completely disperse and set aside.

[0133] (3) Add 1 / 4 mass part of deionized water into the main pot, start homogenization (2000-2800 rpm), add guar hydroxypropyltrimethylammonium chloride and acrylamidopropyltrimethylammonium chloride / acrylamide copolymer in sequence, add 1 / 4 mass part of deionized water after homogenization and dispersion, stir (300-600 rpm) and heat to (80-85) ° C, start homogenization (2000-2800 rpm) and add sodium laureth sulfate, half of the mass parts of cocamidopropyl betaine, disodium laureth sulfosuccinate, half of the mass parts of sodium benzoate, half of the mass parts of cocamide MEA, citric acid, sodium isostearyl lactylate, and disodium EDTA, keep warm and stir for (20-25) min after homogenization and dispersion, check that the material is completely dissolved and then start to cool down.

[0134] (4) Cool down to (75-70)°C, add hydrogenated castor oil, sodium methyl cocoyl taurate, polyglyceryl-10 laurate, remaining cocamide MEA, remaining cocamidopropyl betaine, glycerin, dipropylene glycol, half the mass fraction of 1,2-hexanediol, half the mass fraction of p-hydroxyacetophenone, and pretreated piroctone olamine salt, and continue to cool down after proper homogenization and dissolution. Add all the remaining ingredients at (48-45)°C, stir evenly (low speed homogenization can be used to aid dispersion), and then take samples for testing. If qualified, filter the material with a 100-mesh filter cloth.

[0135] Performance Testing

[0136] Test 1: The shampoos prepared in Examples 1 to 6 were placed in thermostats at 48°C, 5°C, and 25°C, respectively. After the samples were restored to room temperature on the 30th day, the color appearance of the samples and whether the solutions had discoloration, stratification, or precipitation were observed.

[0137] The stability of hot and cold cycles was tested by a 2-day hot and cold cycle. The solution was placed in a -18°C constant temperature box for 1 day and in a 48°C constant temperature box for 1 day. The appearance of the solution was observed after returning to room temperature. A total of five cycles were monitored.

[0138] Table 1 Test results of test 1

[0139]

[0140]

[0141] Test 2: Human trial of anti-hair loss cosmetics

[0142] 1. Materials and Methods

[0143] 1. Trial materials: Examples 1 to 6

[0144] 2. Subjects: A total of 35 subjects, including 12 males and 23 females, aged 30 to 66 years old, with an average age of 43.42±6.72 years old, who met the voluntary inclusion criteria.

[0145] 3. Trial method: Have the subjects use the test product directly according to the usage characteristics and methods indicated on the cosmetic product label, observe or follow up by phone once a week for the skin reactions of the subjects, and record the results according to the grading standards for adverse skin reactions in human trial tests in the "Technical Specifications for Safety of Cosmetics" (2015 edition). The trial period shall be no less than 4 weeks.

[0146] Table 2 Test results of test 2

[0147]

[0148] Test 3: Cosmetic anti-hair loss efficacy test

[0149] Materials and methods

[0150] 1. Test product: Example 1

[0151] 2. Comparative product: Example 2 to Example 6

[0152] 3. Wash-out products: Same as the control products. Both the test group and the control group use the control products during the wash-out period.

[0153] 4. Instruments and Equipment

[0154] 4.1 Professional digital camera: The pixel is not less than 15 million. The parameters including aperture size, sensitivity (ISO) and focal length should remain consistent throughout the test.

[0155] 4.2 Image shooting bracket: It can fix the position of the subject's head so that the top of the head is perpendicular to the camera lens, and use a professional digital camera to take photos of all the hair with the top of the head as the center.

[0156] 4.3 Dermatoscope: LED light source, wavelength 450-750nm, color temperature 6500-8000K, illumination not less than 540lx, magnification ≥20 times, detection diameter not less than 1.0cm or area not less than 0.8cm 2 .

[0157] 4.4 Comb: The tooth density is moderate (tooth spacing 0.9-1.1mm), the tooth length is 2.0-3.0cm, and the comb length is not less than 10cm (excluding the comb handle). The comb of the same specification and material must be used throughout the test. After each use, it must be disinfected in accordance with the relevant requirements of the "Technical Specifications for Disinfection of Medical Institutions" (WS-T 367-2012).

[0158] 5. Subjects: A total of 35 subjects completed the test, including 12 males and 23 females, aged 30 to 66 years old, with an average age of 43.42±6.72 years old. They met the voluntary inclusion and exclusion criteria.

[0159] 6. Test method: The test shall be carried out in accordance with the specific requirements of the currently valid technical specifications and methods. Subjects who pass the initial screening are required to undergo a 2-week wash-out period, and will be screened again after the wash-out period. Qualified subjects selected for the formal trial are divided into the test group and the control group according to the stratified random method, and the test product and the control product are distributed respectively. Use the product correctly according to the product instructions. During the 12-week trial, subjects are required to keep a usage diary and strictly abide by the restrictions. Visits are conducted before product use (baseline value) and 12 weeks after use. The visits are for hair loss counts, assessment of local hair density, visual assessment of hair density, image capture, and records.

[0160] Table 3 Test results of test 3 (mean ± standard deviation) Unit: root

[0161]

[0162]

[0163] Figure 1 This is a photo of the scalp before using the product of Example 1. Figure 2 This is a photo of the scalp after using the product of Example 1.

[0164] The present invention adds polypeptide compounds to the formula, and can obtain a better anti-hair loss effect by combining with plant extracts such as Platycladus orientalis, Sapindus mukorossi, and Ginseng. At the same time, considering the stability of the formula, it is found that the stability and skin irritation are weak when the pH value of the shampoo is adjusted to weak acidity. However, the inventor found that if it is changed to weak acidity, some polypeptide compounds have positive and negative charges, so some of the anionic surfactants, saponin compounds, amino acids, and flavonoid compounds in the formula all cause the instability of the formula, and at the same time form precipitates, affecting the realization of the anti-hair loss effect. For this reason, the inventor adds the presence of a stabilizer on the one hand, and designs the extraction method of extracts such as Sapindus mukorossi, Ginseng, etc. In the preparation process of the shampoo, the emulsification component, emulsification temperature, stirring speed, and the classification of raw materials are planned to obtain a shampoo that is not easy to change color, is not easy to generate precipitation, and is layered, so that the effective ingredients are more used for the realization of the effect.

[0165] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. An anti-shedding composition, characterized in that The composition comprises: soapberry fruit extract, Platycladus orientalis leaf extract, ginseng root extract and peptide compounds.

2. An anti-shedding composition according to claim 1, characterized in that: The composition also includes stabilizers: sodium methyl cocoyl taurate, polyglyceryl-10 laurate, cocamide MEA, cocamidopropyl betaine, glycerin and dipropylene glycol.

3. An anti-shedding composition according to claim 1, characterized in that, The peptide compounds include: acetyl tetrapeptide-5, acetyl tetrapeptide-2, acetyl hexapeptide-8, tetrapeptide-4, palmitoyl tripeptide-8, and arginine / lysine polypeptide.

4. An anti-shedding composition according to claim 1, characterized in that, The method of extracting the ginseng root extract: S01: Weigh an appropriate amount of ginseng root powder and add 10 times the volume of distilled water; extract at 80°C for 2 hours, and cool the extract to room temperature; filter the extract through filter cloth or filter paper to remove residues; centrifuge the filtrate at 4000rpm for 10 minutes and collect the supernatant; S02: gradually add anhydrous ethanol to the supernatant, adjust the ethanol volume fraction to 70% v / v, and stir evenly; let stand for 12 hours, centrifuge to separate the precipitate, collect the supernatant, evaporate the ethanol in the supernatant, and obtain an aqueous extract; S03: loading the aqueous phase extract onto a macroporous adsorption resin column D101 type resin; eluting the column with distilled water, and then eluting with 40%-70% ethanol, collecting the ethanol eluate, and concentrating the eluate into a small amount of liquid for later use; S04: Mix the precipitate obtained in S02 and a small amount of liquid obtained in S03 to obtain the ginseng root extract.

5. An anti-shedding composition according to claim 1, characterized in that, The extraction method of the soapberry fruit extract: (1) Weigh the soapberry fruit powder, add 10 times the weight of distilled water, and extract in a constant temperature water bath at 60° C. for 1 hour; filter with filter cloth or filter paper to obtain a clear soapberry extract; (2) Dissolve the freeze-dried bacteria in sterile water, inoculate into liquid culture medium, and culture at 37°C for 12 hours until OD600 = 1.0; dilute the bacterial solution at a ratio of 1:10 for later use; (3) inoculating the activated bacterial solution into the soapberry extract at a volume ratio of 5%; temperature: 37° C., shaking speed: 120 rpm; time: 48 hours; pH: initially adjusted to 5.5 with lactic acid; (4) After the fermentation is completed, centrifuge at 4000 rpm for 10 minutes to separate the supernatant; concentrate the fermentation broth to 1 / 3 of the original volume using a vacuum concentrator and sterilize at 121°C for 15 minutes; filter using a 0.22 μm filter membrane to remove microorganisms and residual impurities.

6. An anti-shedding composition according to claim 5, characterized in that: The fermentation strain is selected from one or more of lactic acid bacteria (such as Lactobacillus plantarum), yeast (such as Saccharomyces cerevisiae) or Bacillus subtilis.

7. A shampoo, characterized in that: The invention comprises the anti-hair loss composition according to any one of claims 1 to 6.

8. A shampoo according to claim 7, characterized in that: The preparation raw materials include: sodium laureth sulfate, cocamidopropyl betaine, disodium laureth sulfosuccinate, and disodium cocoamphodiacetate.

9. A shampoo according to claim 7, characterized in that: The raw materials for its preparation also include: cocamide MEA, polydimethylsiloxane alcohol, TEA dodecylbenzene sulfonate, and laureth-23.

10. A shampoo according to claim 7, characterized in that: The raw materials for preparing the invention also include: ginger (ZINGIBER OFFICINALE) root extract, scutellaria baicalensis (SCUTELLARIA BAICALENSIS) root extract, rosemary (ROSMARINUS OFFICINALIS) leaf extract, and chamomile (CHAMOMILLA RECUTITA) flower extract.

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