Dairy cow nipple medicated bath powder and preparation method thereof

Abstract

The invention discloses medicated bath powder for dairy cow nipples and a preparation method thereof. The medicated bath powder is used after milking of dairy cows. A composite bactericide in the medicated bath powder is used for killing pathogenic microorganisms and inhibiting bacteria for a long time, anti-inflammatory components, namely calamine, borneol and allantoin, in the medicated bath powder can effectively treat cracked nipples, and an adsorbent and an emollient in the medicated bath powder enable the nipples of the dairy cow to be quickly dried, so that the nipples can recover autoimmune barriers; in addition, due to the dry environment, the bactericidal activity of bactericidal ingredients and anti-inflammatory ingredients in the medicated bath powder for the dairy cow nipples is more lasting, and the effect of the medicated bath powder for the dairy cow nipples is not interfered by the external environment. The invention can achieve the effects of efficient and broad-spectrum sterilization, lasting effect, safety, no side effect, difficult generation of drug resistance, effective treatment of cracked nipples, more economical use, longer shelf life and more convenient transportation, thereby reducing the use cost of pasture.

Description

Technical Field

[0001] The invention belongs to the field of animal husbandry and relates to a cow nipple medicinal bath powder and a preparation method thereof. Background Art

[0002] Mastitis is a common disease in dairy cows. It's a pathological condition caused by an inflammatory response in the cow's mammary glands, leading to decreased milk production and reduced milk quality. Targeted prevention and treatment of mastitis in dairy cows is crucial for the development of the dairy industry. The causes of udder disease in dairy cows are complex, often caused by external mechanical damage that damages the skin barrier, allowing microbial invasion. Long-term exposure to harsh conditions in dairy cows increases the likelihood of pathogenic bacteria multiplying, growing, and spreading, ultimately causing mastitis. Therefore, only by strengthening and implementing appropriate microbial prevention and control measures can the impact of mastitis on the dairy industry be reduced and the economic benefits of dairy farming be effectively improved.

[0003] Currently, the popular medicated baths on the market that have good sterilization effects include alcohol, iodine preparations, and hydrogen peroxide medicated bath products, which are highly irritating. Although moisturizing substances such as glycerin can be added to relieve irritation, in the long run, they will still damage the cow's skin barrier and make the cow's nipples more fragile. In addition, the sterilization effect of these products is short-lived. Quaternary ammonium salts and guanidine medicated baths with lower irritation have a slow sterilization rate. Although the sterilization effect is relatively long-lasting, they are greatly affected by external organic matter and pH, and cannot have a good effect on the udders of cows that have already developed inflammation.

[0004] The present invention provides a dairy cow nipple medicinal bath powder and a preparation method thereof. The present invention can be used after milking a dairy cow. The composite bactericide in the medicinal bath powder kills pathogenic microorganisms and has a long-lasting antibacterial effect. The anti-inflammatory ingredients calamine, borneol, and allantoin in the medicinal bath powder can effectively treat nipple cracks. The adsorbent and emollient in the medicinal bath powder quickly dry the dairy cow nipples, which helps the nipples restore their own immune barrier. The dry environment makes the bactericidal activity of the bactericidal and anti-inflammatory ingredients in the dairy cow nipple medicinal bath powder more lasting, and the effect of the dairy cow nipple medicinal bath powder is not interfered with by the external environment. Therefore, the present invention can achieve high efficiency and broad spectrum of sterilization, long-lasting action, safety and no side effects, is not prone to drug resistance, can effectively treat nipple cracks, and the medicinal bath powder is more economical to use, has a longer shelf life, and is more convenient to transport, thereby reducing the cost of pasture use. Summary of the Invention

[0005] The purpose of the present invention is to provide a cow nipple medicinal bath powder and a preparation method thereof to address the gaps in existing product dosage forms: the medicinal bath powder is not affected by the external environment, is suitable for use in all seasons, has a long-lasting sterilization effect, can treat cow nipple cracks, has low production and use costs, is simple in production process, is convenient in transportation and storage, and can effectively prevent and treat nipple cracks caused by mastitis.

[0006] A dairy cow nipple medicinal bath powder and a preparation method thereof, characterized by being composed of the following components in parts by weight: 40-60 parts of adsorbent 1-5 parts anticaking agent 1-3 parts emollient 11.1-26 parts of anti-inflammatory agent 0.5-1 part of fungicide Skin feel regulator 0.01-0.05 parts 1 part to 5 parts of solvent.

[0007] The present invention uses a variety of guanidine preparations to prepare a compound with high efficiency and broad spectrum, long-lasting effect, safety and no side effects, and is not prone to drug resistance.

[0008] The invention uses calamine, borneol and allantoin to effectively treat chapped nipples of dairy cows.

[0009] The present invention is a solid product that is convenient to transport, convenient to store, and more economical to use, thereby significantly reducing the cost of use. BRIEF DESCRIPTION OF THE DRAWINGS

[0010] Figure 1 Inhibition zone test DETAILED DESCRIPTION

[0011] Example 1 A dairy cow nipple medicinal bath powder, characterized by being composed of the following components in parts by weight: 40 parts of adsorbent 1 part anticaking agent 1 part emollient 11.1 parts of anti-inflammatory agent 0.5 parts of fungicide Skin feel regulator 0.01 1 part solvent Wherein, the adsorbent is a mixture of zinc oxide and kaolin in a ratio of 1:1; Wherein, the anticaking agent is a mixture of corn starch and tricalcium phosphate in a ratio of 1:1; Wherein, the bactericide is a mixture of polyhexamethylene biguanide hydrochloride and chlorhexidine acetate in a ratio of 1:1; Wherein, the emollient is polyethylene glycol 2000; Wherein, the anti-inflammatory agent is a mixture of allantoin, borneol and calamine in a ratio of 1:0.1:10; Wherein, the skin feel regulator is menthol; Wherein, the solvent is a mixture of ethanol and isopropanol in a ratio of 1:1.

[0012] A dairy cow nipple medicinal bath powder and a preparation method thereof comprise the following steps: 1. Weigh polyethylene glycol 2000, menthol, polyhexamethylene biguanide hydrochloride, and chlorhexidine acetate in parts by weight and dissolve them in a solvent to form phase A. 2. Weigh allantoin, borneol, calamine, zinc oxide, kaolin, corn starch, and tricalcium phosphate by weight and grind in a mill at 1000 rpm for 10 minutes to prepare phase B. 3. Spray phase A into phase B according to weight, and stir at 100 r / min for 10 minutes to obtain a dispersion. Turn on the stirring and heat at 70°C, stir and dry for 10 minutes, and pass through a 100-mesh sieve to obtain the cow nipple medicated dip powder.

[0013] Usage: The prepared cow nipple medicinal bath powder can be used on the cow after milking. It can be sprayed using a special powder spray cup, or it can be evenly sprinkled on the affected area of ​​the cow's nipple by hand.

[0014] Example 2 A dairy cow nipple medicinal bath powder, characterized by being composed of the following components in parts by weight: 60 parts of adsorbent 5 parts anticaking agent 3 parts emollient 26 parts of anti-inflammatory agent 1 part fungicide 0.05 parts of skin feel regulator 5 parts solvent Wherein, the adsorbent is a mixture of zinc oxide and kaolin in a ratio of 2:1; Wherein, the anticaking agent is a mixture of corn starch and tricalcium phosphate in a ratio of 1:2; Wherein, the bactericide is a mixture of polyhexamethylene biguanide hydrochloride and chlorhexidine gluconate in a ratio of 1:1; Wherein, the emollient is polyethylene glycol 2000; Wherein, the anti-inflammatory agent is a mixture of allantoin, borneol and calamine in a ratio of 5:1:20; Wherein, the skin feel regulator is vanillyl butyl ether; The solvent is a mixture of ethanol and isopropanol in a ratio of 2:1.

[0015] A dairy cow nipple medicinal bath powder and a preparation method thereof comprise the following steps: 1. Weigh polyethylene glycol 2000, vanillyl butyl ether, polyhexamethylene biguanide hydrochloride, and chlorhexidine gluconate in parts by weight and dissolve them in a solvent to form phase A; 2. Weigh allantoin, borneol, calamine, zinc oxide, kaolin, corn starch, and tricalcium phosphate by weight and grind in a mill at 1000 rpm for 10 minutes to prepare phase B. 3. Spray phase A into phase B according to weight, and stir at 100 r / min for 10 minutes to obtain a dispersion. Turn on the stirring and heat at 70°C, stir and dry for 10 minutes, and pass through a 100-mesh sieve to obtain the cow nipple medicated dip powder.

[0016] Usage: The prepared cow nipple medicinal bath powder can be used on the cow after milking. It can be sprayed using a special powder spray cup, or it can be evenly sprinkled on the affected area of ​​the cow's nipple by hand.

[0017] Example 3 A dairy cow nipple medicinal bath powder, characterized by being composed of the following components in parts by weight: 50 parts of adsorbent 18.5 parts of anti-inflammatory agent 0.8 parts of fungicide 0.03 parts of skin feel regulator 3 parts solvent Wherein, the adsorbent is a mixture of zinc oxide and kaolin in a ratio of 1:2; Wherein, the anticaking agent is a mixture of corn starch and tricalcium phosphate in a ratio of 2:1; Wherein, the bactericide is a mixture of polyhexamethylene biguanide hydrochloride, chlorhexidine gluconate and chlorhexidine acetate in a ratio of 1:1:1; Wherein, the emollient is polyethylene glycol 2000; Wherein, the anti-inflammatory agent is a mixture of allantoin, borneol and calamine in a ratio of 3:0.5:15; Wherein, the skin feel regulator is vanillyl butyl ether; Wherein, the solvent is a mixture of ethanol and isopropanol in a ratio of 1:2.

[0018] A dairy cow nipple medicinal bath powder and a preparation method thereof comprise the following steps: 1. Weigh polyethylene glycol 2000, vanillyl butyl ether, polyhexamethylene biguanide hydrochloride, chlorhexidine gluconate, and chlorhexidine acetate in parts by weight and dissolve them in a solvent as phase A; 2. Weigh allantoin, borneol, calamine, zinc oxide, kaolin, corn starch, and tricalcium phosphate by weight and grind in a mill at 1000 rpm for 10 minutes to prepare phase B. 3. Spray phase A into phase B according to weight, and stir at 100 r / min for 10 minutes to obtain a dispersion. Turn on the stirring and heat at 70°C, stir and dry for 10 minutes, and pass through a 100-mesh sieve to obtain the cow nipple medicated dip powder.

[0019] Usage: The prepared cow nipple medicinal bath powder can be used on the cow after milking. It can be sprayed using a special powder spray cup, or it can be evenly sprinkled on the affected area of ​​the cow's nipple by hand.

[0020] Example 4: Commercially available guanidine preparation for dairy cow teat dip.

[0021] Example 5: 5000ppm povidone-iodine solution for dairy cow teat dip available on the market.

[0022] Sterilization comparison experiment With reference to the standard GB / T 39101-2020, the antibacterial ability of the dairy cow teat dip powder was compared with that of commercially available 5000ppm povidone-iodine solution and guanidine-based dairy cow teat dip in a zone of inhibition test. 1. Experimental process: 1.1. Preparation of bacterial suspension: Reactivate the laboratory-stored E. coli slants and inoculate them onto NA slants at 36°C for 24 hours. Then, inoculate the activated bacteria into NB medium and culture overnight at 36°C. 1.2. Preparation of fungicides: Replace Example 3 with letters, Example 4 with numbers, and Example 5 with PVP-I; 1.3. Plate Preparation: Determine the bacterial concentration in NB medium using a turbidometer and dilute it to a concentration of 1×105-1×106 CFU / mL with sodium chloride tryptone diluent. Pipette 1 mL of the bacterial solution into a sterile culture dish, add 20 mL of PCA, shake well, and allow to solidify. After the culture solidifies, use a sterile 1000 μL pipette tip to make three wells per dish, and three dishes per gradient. 1.4. Assay: Add 100 μg of each of the three fungicides to three wells according to a gradient. Allow to diffuse in a 4°C refrigerator for 1-2 hours. Then, place the wells upright in a 36°C incubator for 18-24 hours. Measure the diameter of the inhibition zone (in mm). 2. Experimental results: 2.1. Inhibition zone test Figure 1 As shown: 2.2. The diameter of the inhibition zone is shown in Table 1: Table 1 Inhibition zone diameter 3. Experimental conclusions: 3.1. The antibacterial ability of each sample of equal mass against Escherichia coli 8099 is compared, Example 3 of the present invention> Example 4> Example 5; 3.2. The bactericidal ability of Example 4 and Example 5 is comparable, but the edge of the inhibition zone of Example 4 is clear, and the edge of Example 5 is gradually blurred. This is because the iodine preparation is volatile, resulting in a weak lasting bactericidal ability, so the long-term bactericidal ability of the cow nipple dipping powder and the guanidine preparation cow nipple dipping solution of the present invention is much greater than that of the 5000ppm povidone-iodine solution cow nipple dipping solution, and the present invention uses a composite guanidine disinfectant, calamine and borneol also have a certain bactericidal ability, so the bactericidal ability of the present invention is stronger than that of the guanidine preparation cow nipple dipping solution; 3.3. Verification of the therapeutic effect of a cow nipple medicinal bath powder: In July, when mastitis was prevalent in dairy cows, a field application was conducted on a ranch in Shaanxi using Examples 3, 4, and 5. Sixty healthy dairy cows and 15 dairy cows with chapped nipples were selected and marked, divided into three groups, and the number of cows was counted. The cows were treated with the products of Example 3, Example 4, and Example 5 for 7 days each after milking, and the status of the cows' nipples was observed 7 days later. The experimental results after 7 days are shown in Table 2: Table 2 Experimental results after 7 days Experiments have shown that the cow nipple medicinal bath powder has significant preventive and therapeutic effects in preventing cow mastitis and treating cow nipple chappedness.

Claims

1. A dairy cow nipple medicinal bath powder and a preparation method thereof, characterized in that It is composed of the following components in parts by weight: Adsorbent 40-60 parts Anticaking agent 1-5 parts 1-3 parts of emollient Anti-inflammatory agent 11.1-26 parts 0.5-1 part of fungicide Skin feel regulator 0.01-0.05 parts 1 part to 5 parts of solvent.

2. The cow nipple medicinal bath powder according to claim 1, characterized in that: The adsorbent is zinc oxide, kaolin or a mixture of any two of them in any proportion.

3. The cow nipple medicinal bath powder according to claim 1, characterized in that: The anticaking agent is any one of tricalcium phosphate and corn starch, or a mixture of any two of them in any proportion.

4. The cow nipple medicinal bath powder according to claim 1, characterized in that: The emollient is polyethylene glycol 2000.

5. The cow nipple medicinal dipping powder according to claim 1, characterized in that: The anti-inflammatory agent is prepared by mixing allantoin, borneol and calamine in a ratio of 1-5:0.5-1:10-20.

6. The cow nipple medicinal bath powder according to claim 1, characterized in that: The auxiliary materials include one or more of a wetting agent, a stabilizer, and a pH adjuster.

7. The cow nipple medicinal bath powder according to claim 1, characterized in that: The bactericide is polyhexamethylene biguanide hydrochloride and any one of chlorhexidine acetate and chlorhexidine gluconate, or a mixture of any two of them in a ratio of 1:0.1-10.

8. The cow nipple medicinal dipping powder according to claim 1, characterized in that: The skin feel regulator is 0.01-0.05 parts of menthol or 0.01-0.05 parts of vanillyl butyl ether. Menthol is used in summer products, and vanillyl butyl ether is used in winter products.

9. The cow nipple medicinal bath powder according to claim 1, characterized in that: The alcohol is any one of ethanol and isopropanol, or a mixture of any two of them in a ratio of 1:1-10.

10. A method for preparing the cow nipple medicinal dipping powder according to any one of claims 1 to 9, characterized in that: The steps include: (1) Weighing an emollient, a skin feel regulator, and a bactericide in parts by weight and dissolving them in a solvent in parts by weight to form phase A; (2) Weighing the anti-inflammatory agent, adsorbent and anti-caking agent by weight, adding them into a grinder and grinding and stirring at 1000 r / min for 10 minutes to prepare phase B; (3) Spray phase A into phase B according to weight, and stir at 100 r / min for 10 minutes to obtain a dispersion. Turn on the stirring and heating at 70°C and stir and dry for 10 minutes. Pass through a 100-mesh sieve to obtain a cow teat dip powder.

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