Organic microcapsule temperature control gel layer, hydrogel cooling patch and preparation method of hydrogel cooling patch

Abstract

The invention discloses an organic microcapsule temperature control gel layer, a hydrogel cooling patch and a preparation method thereof.The organic microcapsule temperature control gel layer comprises a temperature control layer, a bottom hydrogel layer and an upper hydrogel layer, the bottom hydrogel layer and the upper hydrogel layer are arranged on the two sides of the temperature control layer respectively, and the bottom hydrogel layer and the upper hydrogel layer are both made of hydrogel; and the temperature control layer is made of a temperature control material containing organic microcapsules. The hydrogel cooling patch is prepared by adopting the temperature control gel layer containing the organic microcapsules, so that the obtained organic microcapsule hydrogel cooling patch has a lasting and stable temperature control effect and good biocompatibility, and is high in safety, convenient to use and suitable for wide popularization. In addition, the preparation process is simple, easy to operate and suitable for large-scale production.

Description

Technical Field

[0001] The invention belongs to the technical field of medical polymer materials, and in particular relates to an organic microcapsule temperature-control gel layer, a hydrogel cooling patch and a preparation method thereof. Background Art

[0002] With the improvement of people's living standards and the change of aesthetic concepts, the medical beauty industry has risen rapidly. Laser treatment and surgery, as common skin beauty methods, have shown significant effects in removing spots, acne, hair removal, and skin rejuvenation. However, these treatments will inevitably generate heat when acting on the skin, leading to side effects such as thermal damage to the skin, redness, swelling, and pain. Rapid and effective cooling after surgery has become a key link in alleviating these side effects and promoting skin recovery.

[0003] At present, traditional cooling technology has limitations. For example, the cooling effect of ice compress is affected by factors such as ambient temperature and ice melting speed, and it is difficult to maintain a stable cooling effect; the cooling effect of cold spray is weak, and the cooling effect of cold spray is short-lived. It requires special cold spray equipment, which is inconvenient to carry and use, and is easy to cause skin irritation. It is not suitable for all skin types; chemical cooling is affected by ambient temperature and the reaction speed of chemical substances, and it is difficult to maintain a stable cooling effect. The duration is short, and some chemical cooling patches may contain ingredients that are harmful to the skin, posing safety risks. Therefore, it is particularly necessary to develop a new type of cooling patch that is safe, stable, and widely applicable. Summary of the invention

[0004] In view of this, the purpose of the present invention is to provide an organic microcapsule temperature-control gel layer, a hydrogel cooling patch and a preparation method thereof, which solves the problems that existing cooling patches are difficult to maintain a stable cooling effect, the duration is short, and some chemical cooling patches may contain ingredients that are harmful to the skin, posing safety hazards.

[0005] In order to achieve the above-mentioned purpose, the technical solution of the present invention is implemented as follows: an organic microcapsule temperature-control gel layer, which includes a temperature-control layer, a bottom hydrogel layer and an upper hydrogel layer respectively arranged on both sides of the temperature-control layer, and the bottom hydrogel layer and the upper hydrogel layer are both made of hydrogel; the temperature-control layer is made of a temperature-control material containing organic microcapsules.

[0006] Preferably, the temperature control layer is made by mixing sodium polyacrylate and organic microcapsule temperature control material; it contains 2.5 to 5.5 parts of sodium polyacrylate and 20 to 30 parts of organic microcapsule temperature control material.

[0007] Preferably, the core material of the organic microcapsule temperature control material is made of at least one of long-chain alkanes, fatty acids, long-chain esters and fatty alcohols with a molecular weight of 150 to 1500.

[0008] Preferably, the long-chain alkane with a molecular weight of 150 to 1500 is at least one of paraffin, tetradecane, dodecane, and hexadecane; the fatty acid is at least one of caprylic acid, stearic acid, and palmitic acid; the long-chain ester is methyl laurate; and the fatty alcohol is at least one of n-octanol and n-decanol.

[0009] Preferably, the hydrogels used in the bottom hydrogel layer and the upper hydrogel layer include the following components by mass fraction:

[0010] 2.5-5.5 parts of sodium polyacrylate, 25-30 parts of glycerol, 0.012-0.015 parts of aluminum glycolate, 0.8-0.12 parts of disodium EDTA, 0.3-0.7 parts of carboxymethyl cellulose, 0.1-0.4 parts of tartaric acid, and 58-78 parts of pure water.

[0011] Another technical solution of the present invention is achieved as follows: an organic microcapsule hydrogel cooling patch, which includes a backing layer, an anti-sticking layer, and the above-mentioned organic microcapsule temperature-controlling gel layer; the backing layer, the organic microcapsule temperature-controlling gel layer and the anti-sticking layer are stacked in sequence.

[0012] Preferably, the thickness of the temperature-controlling layer in the temperature-controlling gel layer is 2-4 mm, the thickness of the bottom hydrogel layer is 0.5-1 mm, and the thickness of the upper hydrogel layer is 1-3 mm.

[0013] The third technical solution of the present invention is achieved as follows: the preparation method of the above organic microcapsule hydrogel cooling patch specifically comprises the following steps:

[0014] S1. Preparation of bottom hydrogel layer:

[0015] Weigh the following according to mass fraction: 2.5-5.5 parts of sodium polyacrylate, 25-30 parts of glycerol, 0.012-0.015 parts of aluminum glycolate, 0.8-0.12 parts of disodium EDTA, 0.3-0.7 parts of carboxymethyl cellulose, 0.1-0.4 parts of tartaric acid, and 58-78 parts of pure water;

[0016] The sodium polyacrylate, aluminum glycolate, disodium EDTA and carboxymethyl cellulose are dissolved in glycerol and mixed evenly to form a bottom oil phase; the tartaric acid is dissolved in purified water and mixed evenly to form a bottom water phase; the water phase is slowly added to the oil phase and mixed evenly to obtain a bottom hydrogel layer;

[0017] S2, preparing a temperature control layer;

[0018] Weigh respectively according to mass fraction: 2.5-5.5 parts of sodium polyacrylate and 20-30 parts of organic microcapsule temperature control material;

[0019] The sodium polyacrylate and the organic microcapsule temperature control material are mixed evenly, and a certain pressure is applied to form a mixture, and then a temperature control layer with a uniform thickness of 2 to 4 mm is formed;

[0020] S3. Preparation of bottom hydrogel layer:

[0021] Weigh the following according to mass fraction: 2.5-5.5 parts of sodium polyacrylate, 25-30 parts of glycerol, 0.012-0.015 parts of aluminum glycolate, 0.8-0.12 parts of disodium EDTA, 0.3-0.7 parts of carboxymethyl cellulose, 0.1-0.4 parts of tartaric acid, and 58-78 parts of pure water;

[0022] The sodium polyacrylate, aluminum glycolate, disodium EDTA and carboxymethyl cellulose are dissolved in glycerol and mixed evenly to prepare an upper oil phase; the tartaric acid is dissolved in purified water and mixed evenly to prepare an upper water phase; the water phase is slowly added to the oil phase and mixed evenly to obtain an upper hydrogel layer; wherein the volume ratio of the bottom water phase to the upper water phase is 1:(1.5-2);

[0023] S4, coating the bottom layer hydrogel obtained in S1 uniformly on the backing layer, with a coating thickness of 0.5 to 1 mm, to obtain a backing layer coated with the bottom layer hydrogel layer;

[0024] S5, uniformly coating the upper hydrogel obtained in S3 on the anti-adhesive layer, with a coating thickness of 1 to 3 mm, to obtain an anti-adhesive layer coated with the upper hydrogel layer;

[0025] S6, attaching the temperature control layer obtained in S2 to the side of the bottom hydrogel layer away from the backing layer;

[0026] S7, attaching the upper hydrogel layer and the temperature control layer to each other to obtain a semi-finished cooling patch;

[0027] S8, placing the cooling patch semi-finished product at room temperature, pressing a release film on it, cutting it, and packaging it to obtain an organic microcapsule hydrogel cooling patch.

[0028] Preferably, in S2, the applied pressure is 0.5-3 MPa / kg.

[0029] Preferably, in S8, the room temperature placement time is 48 to 72 hours.

[0030] Preferably, the backing layer is made of pharmaceutical grade non-woven fabric; the anti-adhesive film is a PET film, a PC film or a polyurethane film.

[0031] Compared with the prior art, the hydrogel cooling patch is prepared by using the temperature-control gel layer containing organic microcapsules of the present invention, so that the obtained organic microcapsule hydrogel cooling patch has a long-lasting and stable temperature-control effect and good biocompatibility, and is highly safe, easy to use, and suitable for wide promotion. In addition, the preparation process of the present invention is simple, easy to operate, and suitable for large-scale production. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 This is a schematic diagram of the structure of the organic microcapsule temperature control material used in Examples 1-4 of the present invention; wherein 1 represents the capsule core, and 2 represents the capsule shell;

[0033] Figure 2 Schematic diagram of the preparation process of the organic microcapsule hydrogel cooling patch obtained in Examples 1-4 of the present invention; wherein 1 is an upper hydrogel layer (the water phase system is increased by 0.5 to 1 times), 2 is a temperature control layer, 3 is a non-woven fabric layer, 4 is a bottom hydrogel layer, 5 is sodium polyacrylate, 6 is a temperature control material, and 7 is pressure;

[0034] FIG3 is a physical picture of the long-chain alkane capsule hydrogel cooling patch obtained in Example 1 of the present invention; wherein:

[0035] Figure 3A This is a top view of the long-chain alkane microcapsule hydrogel cooling patch;

[0036] Figure 3B This is a real picture of the long-chain alkane microcapsule hydrogel cooling patch from another perspective;

[0037] Figure 4 This is a comparison chart of the actual application temperature change curves of the hexadecane microcapsule hydrogel cooling patch obtained in Examples 1-3 of the present invention and a common cold compress patch. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with specific embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0039] An embodiment of the present invention provides an organic microcapsule temperature-control gel layer, which includes a temperature-control layer, a bottom hydrogel layer and an upper hydrogel layer respectively arranged on both sides of the temperature-control layer, wherein the bottom hydrogel layer and the upper hydrogel layer are both made of hydrogel; and the temperature-control layer is made of a temperature-control material containing organic microcapsules.

[0040] The hydrogel used in the bottom hydrogel layer and the upper hydrogel layer includes the following components by mass fraction: 2.5-5.5 parts of sodium polyacrylate, 25-30 parts of glycerol, 0.012-0.015 parts of aluminum glycolate, 0.8-0.12 parts of disodium EDTA, 0.3-0.7 parts of carboxymethyl cellulose, 0.1-0.4 parts of tartaric acid, and 58-78 parts of pure water; the temperature control layer is made of a mixture of sodium polyacrylate and an organic microcapsule temperature control material; the temperature control layer includes .... parts, and 20 to 30 parts of organic microcapsule temperature control materials; the capsule core material of the organic microcapsule temperature control material is made of at least one of long-chain alkanes, fatty acids, long-chain esters, and fatty alcohols with a molecular weight of 150 to 1500; the long-chain alkanes with a molecular weight of 150 to 1500 are selected from at least one of paraffin, tetradecane, dodecane, and hexadecane; the fatty acid is at least one of octanoic acid, stearic acid, and palmitic acid; the long-chain ester is methyl laurate; and the fatty alcohol is at least one of n-octanol and n-decanol.

[0041] The embodiment of the present invention also provides an organic microcapsule hydrogel cooling patch, which includes a backing layer, an anti-sticking layer, and the above-mentioned organic microcapsule temperature-controlling gel layer; the backing layer, the organic microcapsule temperature-controlling gel layer and the anti-sticking layer are stacked in sequence.

[0042] The thickness of the temperature-controlling layer in the temperature-controlling gel layer is 2-4 mm, the thickness of the bottom hydrogel layer is 0.5-1 mm, and the thickness of the upper hydrogel layer is 1-3 mm.

[0043] The embodiment of the present invention also provides a method for preparing the organic microcapsule hydrogel cooling patch, which specifically comprises the following steps:

[0044] S1. Preparation of bottom hydrogel layer:

[0045] Weigh the following according to mass fraction: 2.5-5.5 parts of sodium polyacrylate, 25-30 parts of glycerol, 0.012-0.015 parts of aluminum glycolate, 0.8-0.12 parts of disodium EDTA, 0.3-0.7 parts of carboxymethyl cellulose, 0.1-0.4 parts of tartaric acid, and 58-78 parts of pure water;

[0046] The sodium polyacrylate, aluminum glycolate, disodium EDTA and carboxymethyl cellulose are dissolved in glycerol and mixed evenly to form a bottom oil phase; the tartaric acid is dissolved in purified water and mixed evenly to form a bottom water phase; the water phase is slowly added to the oil phase and mixed evenly to obtain a bottom hydrogel layer;

[0047] S2, preparing a temperature control layer;

[0048] Weigh respectively according to mass fraction: 2.5-5.5 parts of sodium polyacrylate and 20-30 parts of organic microcapsule temperature control material;

[0049] The sodium polyacrylate and the organic microcapsule temperature control material are mixed evenly, and a pressure of 0.5 to 3 MPa / kg is applied to form a mixture, and then a temperature control layer with a uniform thickness of 2 to 4 mm is formed;

[0050] S3. Preparation of bottom hydrogel layer:

[0051] Weigh the following according to mass fraction: 2.5-5.5 parts of sodium polyacrylate, 25-30 parts of glycerol, 0.012-0.015 parts of aluminum glycolate, 0.8-0.12 parts of disodium EDTA, 0.3-0.7 parts of carboxymethyl cellulose, 0.1-0.4 parts of tartaric acid, and 58-78 parts of pure water;

[0052] The sodium polyacrylate, aluminum glycolate, disodium EDTA and carboxymethyl cellulose are dissolved in glycerol and mixed evenly to prepare an upper oil phase; the tartaric acid is dissolved in purified water and mixed evenly to prepare an upper water phase; the water phase is slowly added to the oil phase and mixed evenly to obtain an upper hydrogel layer; wherein the volume ratio of the bottom water phase to the upper water phase is 1:(1.5-2);

[0053] S4, coating the bottom layer hydrogel obtained in S1 evenly on the backing layer, with a coating thickness of 0.5 to 1 mm, to obtain a backing layer coated with the bottom layer hydrogel layer; the backing layer is made of pharmaceutical grade non-woven fabric;

[0054] S5, uniformly coating the upper hydrogel obtained in S3 on the anti-adhesive layer, with a coating thickness of 1 to 3 mm, to obtain an anti-adhesive layer coated with an upper hydrogel layer; the anti-adhesive film is a PET film, a PC film or a polyurethane film;

[0055] S6, attaching the temperature control layer obtained in S2 to the side of the bottom hydrogel layer away from the backing layer;

[0056] S7, attaching the upper hydrogel layer and the temperature control layer to each other to obtain a semi-finished cooling patch;

[0057] S8. Place the semi-finished cooling patch at room temperature for 48 to 72 hours, apply a release film, cut, and package to obtain an organic microcapsule hydrogel cooling patch.

[0058] In addition, the above-mentioned temperature control material containing organic microcapsules is in the form of microcapsules, see Figure 1 The temperature control material uses a microfluidic method to evenly cover a layer of silicon dioxide as a capsule shell on the surface of the capsule core, and the particle size is 20 μm; it is specifically obtained by the following steps:

[0059] S1. A microfluidic chip having a T-shaped structure and a microchannel with a width of 100 μm and a depth of 50 μm was prepared by a microfluidic method;

[0060] S2, 1g of organic microcapsules (the capsule core material is made of at least one of long-chain alkanes, fatty acids, long-chain esters, and fatty alcohols with a molecular weight of 150-1500; the long-chain alkanes with a molecular weight of 150-1500 are selected from at least one of paraffin, tetradecane, dodecane, and hexadecane; the fatty acid is at least one of octanoic acid, stearic acid, and palmitic acid; the long-chain ester is methyl laurate; the fatty alcohol is at least one of n-octanol and n-decanol) are dispersed in amino-polydimethylsiloxane and tetraethyl orthosilicate accounting for 1% by mass of the long-chain alkanes, and then 50mL of ethanol and a surfactant polyvinyl alcohol accounting for 0.1% by mass of the long-chain alkanes are added, and a stable dispersion of the temperature-control material is obtained by stirring for 30 minutes as the inner phase;

[0061] S3, dissolving 0.5 g of silicon dioxide and 1 g of polyurethane in 50 mL of ethanol, stirring evenly to obtain a uniform capsule shell layer solution;

[0062] S4, respectively introducing the temperature control material dispersion and the shell solution into the microchannel of the microfluidic chip, adjusting the flow rate ratio to 1:1 (the flow rate of the core material dispersion is 0.011 mL / min, and the flow rate of the shell solution is 0.011 mL / min) to prepare a high internal phase emulsion;

[0063] S5, adding 50 mL of hydrochloric acid solution as a catalyst dropwise into the high internal phase emulsion to initiate polymerization, thereby generating an organic microcapsule polymer with a particle size of 10 μm and uniform particle size;

[0064] S6. Add ethanol and ionized water to the microcapsule-type polymer, wash three times, and then dry at room temperature of 25° C. or at a high temperature not exceeding 60° C. for 30 h to obtain an organic microcapsule temperature control material with a particle size of 20 μm and uniform particle size.

[0065] The following are examples

[0066] Example 1

[0067] The long-chain alkane microcapsule hydrogel cooling patch provided in Example 1 of the present invention is obtained by the following method (see Figure 2 shown):

[0068] S1. Preparation of bottom hydrogel layer:

[0069] Weigh out the following by mass fraction: 5.156 g sodium polyacrylate, 15.625 g glycerol, 0.0875 g aluminum glycolate, 0.0625 g disodium EDTA, 0.3125 g carboxymethyl cellulose, 0.125 g tartaric acid, and 42.5 g pure water;

[0070] The sodium polyacrylate, aluminum glycolate, disodium EDTA and carboxymethyl cellulose are weighed and dissolved in glycerol and mixed evenly to form a bottom oil phase; the tartaric acid is dissolved in purified water and mixed evenly to form a bottom water phase; the water phase is slowly added to the oil phase and mixed evenly to obtain a bottom hydrogel layer;

[0071] S2, preparing a temperature control layer containing a long-chain alkane microcapsule temperature control material;

[0072] Weigh out 2.5 g of sodium polyacrylate and 18.9 g of long-chain alkane microcapsule temperature control material according to mass fraction;

[0073] The sodium polyacrylate and the long-chain alkane microcapsule temperature control material are mixed evenly, and a pressure of 0.5 to 3 MPa / kg is applied to form a mixture, and then a uniform loading of 0.2 to 0.7 g / cm is formed into a 2 mm thick 2 And the temperature control layer contains long-chain alkane microcapsule temperature control material;

[0074] S3. Preparation of bottom hydrogel layer:

[0075] Weigh out the following by mass fraction: 5.156 g sodium polyacrylate, 15.625 g glycerol, 0.0875 g aluminum glycolate, 0.0625 g disodium EDTA, 0.3125 g carboxymethyl cellulose, 0.125 g tartaric acid, and 42.5 g pure water;

[0076] The sodium polyacrylate, aluminum glycolate, disodium EDTA and carboxymethyl cellulose are dissolved in glycerol and mixed evenly to prepare an upper oil phase; the tartaric acid is dissolved in purified water and mixed evenly to prepare an upper water phase; the water phase is slowly added to the oil phase and mixed evenly to obtain an upper hydrogel layer; wherein the volume ratio of the bottom water phase to the upper water phase is 1:(1.5-2);

[0077] S4, uniformly coating the bottom layer hydrogel obtained in S1 on a medical non-woven fabric, with a coating thickness of 1 mm, to obtain a non-woven fabric coated with a bottom layer hydrogel layer;

[0078] S5, uniformly coating the upper hydrogel obtained in S3 on a PET film with a coating thickness of 2 mm to obtain a PET film coated with an upper hydrogel layer;

[0079] S6, attaching the temperature control layer obtained in S2 to the side of the bottom hydrogel layer away from the non-woven fabric;

[0080] S7, attaching the upper hydrogel layer and the temperature control layer to each other to obtain a semi-finished cooling patch;

[0081] S8, place the semi-finished cooling patch at room temperature for 48 to 72 hours, press the anti-adhesive film, cut and package to obtain a long-chain alkane microcapsule hydrogel cooling patch (see the actual picture for details) Figure 3A , Figure 3B ).

[0082] Example 2

[0083] The fatty acid microcapsule hydrogel cooling patch provided in Example 2 of the present invention is obtained by the following method (see Figure 2 shown):

[0084] S1. Preparation of bottom hydrogel layer:

[0085] Weigh out the following by mass fraction: 5.156 g sodium polyacrylate, 15.625 g glycerol, 0.0875 g aluminum glycolate, 0.0625 g disodium EDTA, 0.3125 g carboxymethyl cellulose, 0.125 g tartaric acid, and 42.5 g pure water;

[0086] The sodium polyacrylate, aluminum glycolate, disodium EDTA and carboxymethyl cellulose are weighed and dissolved in glycerol and mixed evenly to form a bottom oil phase; the tartaric acid is dissolved in purified water and mixed evenly to form a bottom water phase; the water phase is slowly added to the oil phase and mixed evenly to obtain a bottom hydrogel layer;

[0087] S2, preparing a temperature control layer containing fatty acid microcapsule temperature control material;

[0088] Weigh out 2.5 g of sodium polyacrylate and 18.9 g of fatty acid microcapsule temperature control material according to mass fraction;

[0089] The sodium polyacrylate and the fatty acid microcapsule temperature control material are mixed evenly, and a pressure of 0.5 to 3 MPa / kg is applied to form a mixture, and then a uniform loading of 0.2 to 0.7 g / cm is formed into a 2 mm thick 2 And a temperature control layer containing fatty acid microcapsule temperature control material;

[0090] S3. Preparation of bottom hydrogel layer:

[0091] Weigh out the following by mass fraction: 5.156 g sodium polyacrylate, 15.625 g glycerol, 0.0875 g aluminum glycolate, 0.0625 g disodium EDTA, 0.3125 g carboxymethyl cellulose, 0.125 g tartaric acid, and 42.5 g pure water;

[0092] The sodium polyacrylate, aluminum glycolate, disodium EDTA and carboxymethyl cellulose are dissolved in glycerol and mixed evenly to prepare an upper oil phase; the tartaric acid is dissolved in purified water and mixed evenly to prepare an upper water phase; the water phase is slowly added to the oil phase and mixed evenly to obtain an upper hydrogel layer; wherein the volume ratio of the bottom water phase to the upper water phase is 1:(1.5-2);

[0093] S4, uniformly coating the bottom layer hydrogel obtained in S1 on a medical non-woven fabric, with a coating thickness of 1 mm, to obtain a non-woven fabric coated with a bottom layer hydrogel layer;

[0094] S5, uniformly coating the upper hydrogel obtained in S3 on a PET film with a coating thickness of 2 mm to obtain a PET film coated with an upper hydrogel layer;

[0095] S6, attaching the temperature control layer obtained in S2 to the side of the bottom hydrogel layer away from the non-woven fabric;

[0096] S7, attaching the upper hydrogel layer and the temperature control layer to each other to obtain a semi-finished cooling patch;

[0097] S8. Place the semi-finished cooling patch at room temperature for 48 to 72 hours, apply a release film, cut, and package to obtain a fatty acid microcapsule hydrogel cooling patch.

[0098] Example 3

[0099] The long-chain ester microcapsule hydrogel cooling patch provided in Example 3 of the present invention is obtained by the following method (see Figure 2 shown):

[0100] S1. Preparation of bottom hydrogel layer:

[0101] Weigh out the following by mass fraction: 5.156 g sodium polyacrylate, 15.625 g glycerol, 0.0875 g aluminum glycolate, 0.0625 g disodium EDTA, 0.3125 g carboxymethyl cellulose, 0.125 g tartaric acid, and 42.5 g pure water;

[0102] The sodium polyacrylate, aluminum glycolate, disodium EDTA and carboxymethyl cellulose are weighed and dissolved in glycerol and mixed evenly to form a bottom oil phase; the tartaric acid is dissolved in purified water and mixed evenly to form a bottom water phase; the water phase is slowly added to the oil phase and mixed evenly to obtain a bottom hydrogel layer;

[0103] S2, preparing a temperature control layer containing a long-chain ester microcapsule temperature control material;

[0104] Weigh out 2.5 g of sodium polyacrylate and 18.9 g of long-chain ester microcapsule temperature control material according to mass fraction;

[0105] The sodium polyacrylate and the long-chain ester microcapsule temperature control material are mixed evenly, and a pressure of 0.5 to 3 M pa / kg is applied to form a mixture, and then a uniform loading of 0.2 to 0.7 g / cm is formed into a 2 mm thick microcapsule. 2 And the temperature control layer contains long-chain ester microcapsule temperature control material;

[0106] S3. Preparation of bottom hydrogel layer:

[0107] Weigh out the following by mass fraction: 5.156 g sodium polyacrylate, 15.625 g glycerol, 0.0875 g aluminum glycolate, 0.0625 g disodium EDTA, 0.3125 g carboxymethyl cellulose, 0.125 g tartaric acid, and 42.5 g pure water;

[0108] The sodium polyacrylate, aluminum glycolate, disodium EDTA and carboxymethyl cellulose are dissolved in glycerol and mixed evenly to prepare an upper oil phase; the tartaric acid is dissolved in purified water and mixed evenly to prepare an upper water phase; the water phase is slowly added to the oil phase and mixed evenly to obtain an upper hydrogel layer; wherein the volume ratio of the bottom water phase to the upper water phase is 1:(1.5-2);

[0109] S4, uniformly coating the bottom layer hydrogel obtained in S1 on a medical non-woven fabric, with a coating thickness of 1 mm, to obtain a non-woven fabric coated with a bottom layer hydrogel layer;

[0110] S5, uniformly coating the upper hydrogel obtained in S3 on a PET film with a coating thickness of 2 mm to obtain a PET film coated with an upper hydrogel layer;

[0111] S6, attaching the temperature control layer obtained in S2 to the side of the bottom hydrogel layer away from the non-woven fabric;

[0112] S7, attaching the upper hydrogel layer and the temperature control layer to each other to obtain a semi-finished cooling patch;

[0113] S8. Place the semi-finished cooling patch at room temperature for 48 to 72 hours, apply a release film, cut, and package to obtain a long-chain ester microcapsule hydrogel cooling patch.

[0114] Example 4

[0115] The fatty alcohol microcapsule hydrogel cooling patch provided in Example 4 of the present invention is obtained by the following method (see Figure 2 shown):

[0116] S1. Preparation of bottom hydrogel layer:

[0117] Weigh out the following by mass fraction: 5.156 g sodium polyacrylate, 15.625 g glycerol, 0.0875 g aluminum glycolate, 0.0625 g disodium EDTA, 0.3125 g carboxymethyl cellulose, 0.125 g tartaric acid, and 42.5 g pure water;

[0118] The sodium polyacrylate, aluminum glycolate, disodium EDTA and carboxymethyl cellulose are weighed and dissolved in glycerol and mixed evenly to form a bottom oil phase; the tartaric acid is dissolved in purified water and mixed evenly to form a bottom water phase; the water phase is slowly added to the oil phase and mixed evenly to obtain a bottom hydrogel layer;

[0119] S2, preparing a temperature control layer containing fatty alcohol microcapsule temperature control material;

[0120] Weigh out 2.5 g of sodium polyacrylate and 18.9 g of fatty alcohol microcapsule temperature control material according to mass fraction;

[0121] The sodium polyacrylate and the fatty alcohol microcapsule temperature control material are mixed evenly, and a pressure of 0.5 to 3 MPa / kg is applied to form a mixture, and then a uniform loading of 0.2 to 0.7 g / cm is formed into a 2 mm thick 2 And a temperature control layer containing fatty alcohol microcapsule temperature control material;

[0122] S3. Preparation of bottom hydrogel layer:

[0123] Weigh out the following by mass fraction: 5.156 g sodium polyacrylate, 15.625 g glycerol, 0.0875 g aluminum glycolate, 0.0625 g disodium EDTA, 0.3125 g carboxymethyl cellulose, 0.125 g tartaric acid, and 42.5 g pure water;

[0124] The sodium polyacrylate, aluminum glycolate, disodium EDTA and carboxymethyl cellulose are dissolved in glycerol and mixed evenly to prepare an upper oil phase; the tartaric acid is dissolved in purified water and mixed evenly to prepare an upper water phase; the water phase is slowly added to the oil phase and mixed evenly to obtain an upper hydrogel layer; wherein the volume ratio of the bottom water phase to the upper water phase is 1:(1.5-2);

[0125] S4, uniformly coating the bottom layer hydrogel obtained in S1 on a medical non-woven fabric, with a coating thickness of 1 mm, to obtain a non-woven fabric coated with a bottom layer hydrogel layer;

[0126] S5, uniformly coating the upper hydrogel obtained in S3 on a PET film with a coating thickness of 2 mm to obtain a PET film coated with an upper hydrogel layer;

[0127] S6, attaching the temperature control layer obtained in S2 to the side of the bottom hydrogel layer away from the non-woven fabric;

[0128] S7, attaching the upper hydrogel layer and the temperature control layer to each other to obtain a semi-finished cooling patch;

[0129] S8. Place the semi-finished cooling patch at room temperature for 48 to 72 hours, apply a release film, cut, and package to obtain a fatty alcohol microcapsule hydrogel cooling patch.

[0130] The following are specific embodiments

[0131] According to the method of the above-mentioned Example 1, by adjusting the type of long-chain alkane selected for the core of the microcapsule temperature control material, the thickness of the temperature control layer and the load of the temperature control layer of the microcapsule temperature control material caused by the pressure change, and keeping other process parameters unchanged, the long-chain alkane microcapsule hydrogel cooling patches of Examples 1-1 to 1-8 as shown in Table 1 below are obtained.

[0132] Table 1 Related parameters of the long-chain alkane microcapsule hydrogel cooling patch obtained in Examples 1-1 to 1-8

[0133]

[0134] Further, according to the method of the above-mentioned Example 2, by adjusting the type of fatty acid selected for the core of the microcapsule temperature control material, the thickness of the temperature control layer, the load amount of the temperature control layer of the microcapsule temperature control material caused by the pressure change, and keeping other process parameters unchanged, the fatty acid microcapsule hydrogel cooling patches of Examples 2-1 to 2-3 as shown in Table 2 were obtained.

[0135] Table 2 Related parameters of the long-chain ester microcapsule hydrogel cooling patch obtained in Examples 2-1 to 2-3

[0136]

[0137] Furthermore, according to the method of the above-mentioned Example 3, by adjusting the type of long-chain ester selected for the core of the microcapsule temperature control material, the thickness of the temperature control layer, the load amount of the temperature control layer of the microcapsule temperature control material caused by the pressure change, and keeping other process parameters unchanged, the long-chain ester microcapsule hydrogel cooling patch of Example 3-1 as shown in Table 3 below was obtained.

[0138] Table 3 Related parameters of the long-chain ester microcapsule hydrogel cooling patch obtained in Example 3-1

[0139]

[0140] Further, according to the method of the above-mentioned Example 4, by adjusting the type of fatty alcohol selected for the core of the microcapsule temperature control material, the thickness of the temperature control layer, the load amount of the temperature control layer of the microcapsule temperature control material caused by the pressure change, and keeping other process parameters unchanged, the fatty alcohol microcapsule hydrogel cooling patches of Example 4-1 and Example 4-2 as shown in Table 4 below were obtained.

[0141] Table 4 Related parameters of fatty alcohol microcapsule hydrogel cooling patches obtained in Example 4-1 and Example 4-2

[0142]

[0143]

[0144] Combined with the above specific embodiments, in order to verify the performance of the organic microcapsule hydrogel cooling patch obtained in the embodiment of the present invention, a practical application temperature change test is now carried out, and the specific method is as follows:

[0145] The temperature control performance of the common cold compress mask on the market was compared with that of the tetradecane microcapsule hydrogel cooling patch and the caprylic acid microcapsule hydrogel cooling patch of Example 1-2 and Example 2-1 respectively, and the temperature change and temperature control time were tested at room temperature (25°C). Figure 4 ).

[0146] Through experimental tests and comparisons, it is known that Figure 4 It can be seen that the organic microcapsule hydrogel cooling patch obtained by the present invention has excellent temperature control performance and cold storage performance, the average temperature of the temperature control platform period is 9-11°C, and the average temperature control time is 10-20min.

[0147] In summary, by using the temperature-control gel layer containing organic microcapsules of the present invention to prepare a hydrogel cooling patch, the obtained organic microcapsule hydrogel cooling patch has a long-lasting and stable temperature-control effect and good biocompatibility, and is highly safe, easy to use, and suitable for wide promotion. In addition, the preparation process of the present invention is simple, easy to operate, and suitable for large-scale production.

[0148] The above is only a preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily thought of by a person skilled in the art within the technical scope disclosed by the present invention should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. An organic microcapsule temperature-control gel layer, characterized in that: The organic microcapsule temperature control gel layer comprises a temperature control layer, a bottom hydrogel layer and an upper hydrogel layer respectively arranged on both sides of the temperature control layer, wherein the bottom hydrogel layer and the upper hydrogel layer are both made of hydrogel; the temperature control layer is made of a temperature control material containing organic microcapsules.

2. The organic microcapsule temperature-controlling gel layer according to claim 1, characterized in that: The temperature control layer is made by mixing sodium polyacrylate and organic microcapsule temperature control material; it contains 2.5-5.5 parts of sodium polyacrylate and 20-30 parts of organic microcapsule temperature control material.

3. The organic microcapsule temperature-controlling gel layer according to claim 2, characterized in that: The capsule core material of the organic microcapsule temperature control material is made of at least one of long-chain alkanes, fatty acids, long-chain esters and fatty alcohols with a molecular weight of 150 to 1500.

4. The organic microcapsule temperature-controlling gel layer according to claim 3, characterized in that: The long-chain alkane with a molecular weight of 150 to 1500 is at least one of paraffin, tetradecane, dodecane, and hexadecane; the fatty acid is at least one of octanoic acid, stearic acid, and palmitic acid; the long-chain ester is methyl laurate; and the fatty alcohol is at least one of n-octanol and n-decanol.

5. The organic microcapsule temperature-controlling gel layer according to any one of claims 1 to 4, characterized in that: The hydrogels used in the bottom hydrogel layer and the upper hydrogel layer include the following components by mass fraction: 2.5-5.5 parts of sodium polyacrylate, 25-30 parts of glycerol, 0.012-0.015 parts of aluminum glycolate, 0.8-0.12 parts of disodium EDTA, 0.3-0.7 parts of carboxymethyl cellulose, 0.1-0.4 parts of tartaric acid, and 58-78 parts of pure water.

6. An organic microcapsule hydrogel cooling patch, characterized in that: The organic microcapsule hydrogel cooling patch comprises a backing layer, an anti-adhesion layer, and the organic microcapsule temperature-controlling gel layer according to any one of claims 1 to 5; the backing layer, the organic microcapsule temperature-controlling gel layer, and the anti-adhesion layer are stacked in sequence.

7. The organic microcapsule hydrogel cooling patch according to claim 6, characterized in that: The thickness of the temperature control layer in the temperature control gel layer is 2-4 mm, the thickness of the bottom hydrogel layer is 0.5-1 mm, and the thickness of the upper hydrogel layer is 1-3 mm.

8. A method for preparing the organic microcapsule hydrogel cooling patch according to claim 6 or 7, characterized in that: The method specifically comprises the following steps: S1. Preparation of bottom hydrogel layer: Weigh the following according to mass fraction: 2.5-5.5 parts of sodium polyacrylate, 25-30 parts of glycerol, 0.012-0.015 parts of aluminum glycolate, 0.8-0.12 parts of disodium EDTA, 0.3-0.7 parts of carboxymethyl cellulose, 0.1-0.4 parts of tartaric acid, and 58-78 parts of pure water; The sodium polyacrylate, aluminum glycolate, disodium EDTA and carboxymethyl cellulose are dissolved in glycerol and mixed evenly to form a bottom oil phase; the tartaric acid is dissolved in purified water and mixed evenly to form a bottom water phase; the water phase is slowly added to the oil phase and mixed evenly to obtain a bottom hydrogel layer; S2, preparing a temperature control layer; Weigh respectively according to mass fraction: 2.5-5.5 parts of sodium polyacrylate and 20-30 parts of organic microcapsule temperature control material; The sodium polyacrylate and the organic microcapsule temperature control material are mixed evenly, and a certain pressure is applied to form a mixture, and then a temperature control layer with a uniform thickness of 2 to 4 mm is formed; S3. Preparation of bottom hydrogel layer: Weigh the following according to mass fraction: 2.5-5.5 parts of sodium polyacrylate, 25-30 parts of glycerol, 0.012-0.015 parts of aluminum glycolate, 0.8-0.12 parts of disodium EDTA, 0.3-0.7 parts of carboxymethyl cellulose, 0.1-0.4 parts of tartaric acid, and 58-78 parts of pure water; The sodium polyacrylate, aluminum glycolate, disodium EDTA and carboxymethyl cellulose are dissolved in glycerol and mixed evenly to prepare an upper oil phase; the tartaric acid is dissolved in purified water and mixed evenly to prepare an upper water phase; the water phase is slowly added to the oil phase and mixed evenly to obtain an upper hydrogel layer; wherein the volume ratio of the bottom water phase to the upper water phase is 1:(1.5-2); S4, coating the bottom layer hydrogel obtained in S1 uniformly on the backing layer, with a coating thickness of 0.5 to 1 mm, to obtain a backing layer coated with the bottom layer hydrogel layer; S5, uniformly coating the upper hydrogel obtained in S3 on the anti-adhesive layer, with a coating thickness of 1 to 3 mm, to obtain an anti-adhesive layer coated with the upper hydrogel layer; S6, attaching the temperature control layer obtained in S2 to the side of the bottom hydrogel layer away from the backing layer; S7, attaching the upper hydrogel layer and the temperature control layer to each other to obtain a semi-finished cooling patch; S8, placing the cooling patch semi-finished product at room temperature, pressing a release film on it, cutting it, and packaging it to obtain an organic microcapsule hydrogel cooling patch.

9. The method for preparing the organic microcapsule hydrogel cooling patch according to claim 7, characterized in that: In S2, the applied pressure is 0.5 to 3 MPa / kg.

10. The method for preparing the organic microcapsule hydrogel cooling patch according to claim 7, characterized in that: In S8, the room temperature standing time is 48 to 72 hours.

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