Bactericidal composition containing hymexazol and difenoconazole and application thereof
By combining oximerin and phenyl ethermethycinazole in the fungicide, the problem of limited effectiveness of existing fungicides in preventing and treating wheat total corrosion diseases has been solved, and the purpose of significantly improving the prevention and treatment effect has been achieved.
Patent Information
- Application Number
- CN202510196377.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-21
- Publication Date
- 2025-05-27
AI Technical Summary
Existing fungicides have limited effects in preventing and treating wheat total corrosion disease and cannot meet the needs of higher prevention and treatment effects.
The bactericidal composition containing oxamycin and phenyl ether mecyclazole is used to inhibit the growth and reproduction of total erosion pathogenic bacteria through mutual enhancement.
It significantly improves the effect of preventing and treating wheat total corrosion disease, with the prevention and treatment effect exceeding 81%, and has the advantages of synergistic efficiency, high efficacy, long-lasting efficacy and good prevention and treatment effect.
Smart Images
Figure BDA0005281612160000041 
Figure BDA0005281612160000051
Abstract
Description
Technical Field
[0001] The present application relates to the technical field of fungicidal compositions, and more specifically, to a fungicidal composition containing oxadipazole and difenoconazole and its application. Background Art
[0002] In agricultural production, the frequency of occurrence of crop diseases is high, which seriously affects the yield and quality of crops. In order to effectively prevent and control these diseases, fungicidal compositions are widely used to prevent and treat various crop diseases, especially wheat take-all disease, which is of great significance to improving wheat yield and quality. Wheat take-all disease is a root disease, also known as damping-off or blackleg disease. Wheat take-all disease can cause clusters or large areas of plant death, reduce the number of effective ears, the number of grains per ear and the thousand-grain weight, and seriously affect wheat yield and quality. Wheat take-all disease can occur throughout the growth period, and the symptoms of diseased plants are most obvious when they are about to mature. For the prevention and control of wheat take-all disease, some researchers have selected fungicides such as oxazolidinone, tetrazolium pyrazone, fluopicolide, silthiopyrad, and polyoxin for prevention and control, but their prevention and control effects are limited and cannot meet the needs of higher prevention and control effects, and the prevention and control effects need to be further improved. Summary of the invention
[0003] In order to improve the control effect of the fungicide composition against wheat take-all disease, the present application provides a fungicide composition containing oxadipamide and difenoconazole and its application.
[0004] In the first aspect, the present application provides a fungicide composition containing oxadipamide and difenoconazole, which adopts the following technical scheme: A fungicide composition containing oxadipamide and difenoconazole, wherein the active ingredients in the fungicide composition are oxadipamide and difenoconazole, and the weight ratio of oxadipamide to difenoconazole is (2-3):1.
[0005] The bactericidal composition of the present application adopts oxadipazole and difenoconazole as active ingredients, and utilizes the mutual synergism of the two to inhibit the growth and reproduction of the pathogenic bacteria of take-all disease, can effectively prevent and control the occurrence of take-all disease, improve the control effect, especially the control effect of wheat take-all disease shows a significant advantage, and the control effect is>81%. And the amount of oxadipazole used is greater than the amount of difenoconazole used. When the weight ratio of oxadipazole and difenoconazole is selected within the range of (2-3):1, the respective advantages can be fully utilized to improve safety and efficacy. The bactericidal composition of the present application has the advantages of synergistic synergy, high efficacy, long-lasting efficacy, and good control effect, and can be widely promoted and applied.
[0006] Optionally, the total mass percentage of active ingredients in the fungicide composition is 0.5-5%.
[0007] By adopting the above technical scheme, the content of active ingredients in the bactericidal composition is optimized, and on the basis of ensuring that the bactericidal composition has a good bactericidal effect, the concentration of the active ingredients in the bactericidal composition is reduced, the utilization rate of the active ingredients is improved, and the safety and economy of the medication are increased.
[0008] Optionally, the dosage form of the bactericidal composition is granules.
[0009] By adopting the above technical solution, the bactericidal composition is prepared into granules, which is convenient for transportation and storage of the bactericidal composition.
[0010] Optionally, the average particle size of the bactericidal composition is 0.1-5 mm. Preferably, the average particle size of the bactericidal composition is 0.5-2 mm.
[0011] By adopting the above technical solution, the average particle size of the bactericidal composition is optimized, which is convenient for the preparation of the bactericidal composition. And when the average particle size of the bactericidal composition is selected within the range of 0.1-5mm, the bactericidal composition can maintain good efficacy. In multiple embodiments, the average particle size of the bactericidal composition is 1mm, and the average particle size can be set to 0.1mm, 0.3mm, 0.5mm, 0.7mm, 1.3mm, 1.5mm, 1.7mm, 2mm, 2.3mm, 2.5mm, 2.7mm, 3mm, 3.5mm, 4mm, 4.5mm, 5mm as needed, but it is not limited to the listed values, and other values not listed within the numerical range are also applicable.
[0012] Optionally, the bactericidal composition is mainly composed of the following components in weight percentage: 0.5-5% of active ingredient, 0-0.3% of synergistic auxiliary agent, 1-3% of binder, 2-4% of wetting agent, 4-6% of adsorbent, and the balance is filler.
[0013] By adopting the above technical solution, the components and component ratios of the fungicide composition are optimized, which facilitates the preparation of the fungicide composition. In addition, by utilizing the mutual coordination between the binder, the wetting agent, the adsorbent, and the filler, the active ingredients are prepared into granules, which facilitates the preparation, application, and storage of the fungicide composition, and is suitable for the application in preventing crop take-all disease.
[0014] Optionally, the synergist is 5-ethoxycarbonyl-2-thienylzinc bromide.
[0015] By adopting the above technical scheme, 5-ethoxycarbonyl-2-thienyl zinc bromide is selected as the synergistic auxiliary agent. 5-ethoxycarbonyl-2-thienyl zinc bromide can promote the efficacy of catalyzing meconazole and difenoconazole, improve the utilization rate of the fungicide composition, enhance the durability of the efficacy and the control effect on wheat take-all disease.
[0016] Optionally, the binder is one or more of ethyl cellulose, carboxyethyl cellulose, carboxymethyl cellulose, polyvinyl pyrrolidone, and starch.
[0017] By adopting the above technical solution, the binder is optimized, which facilitates the selection of the binder. Moreover, the binder can enhance the binding force between the components, facilitate the molding and stability of the granules, enhance the wear resistance and anti-crushing ability of the granules, and ensure the storage stability and use effect of the sterilization composition.
[0018] Optionally, the wetting agent is one or more of tristyrylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, castor oil polyoxyethylene ether, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, and dioctyl sodium sulfosuccinate.
[0019] By adopting the above technical solution, the wetting agent is optimized, which facilitates the selection of the wetting agent. Moreover, the wetting agent can improve the wetting and penetration ability, thereby improving the sterilization and prevention effect of the sterilization composition.
[0020] Optionally, the adsorbent is one or more of white carbon black, activated carbon, biochar, silica gel, and silicon dioxide.
[0021] By adopting the above technical solution, the adsorbent is optimized, which facilitates the selection of the adsorbent. Moreover, the adsorbent has a high specific surface area and pore structure, which can effectively prolong the duration of the drug effect and increase the persistence of the drug effect.
[0022] Optionally, the filler is one or more of clay, diatomaceous earth, bentonite, attapulgite and talc.
[0023] By adopting the above technical solution, the filler is optimized and the selection of the filler is facilitated.
[0024] Optionally, the preparation method of the bactericidal composition mainly comprises the following steps: S1. Mixing oxadipamide, difenoconazole, a synergist, a binder, a wetting agent, an adsorbent, and a filler to obtain a mixed material; S2, kneading the mixed material and water, extruding and granulating, and obtaining sterilization granules; S3, drying and sieving the bactericidal particles to obtain a bactericidal composition.
[0025] By adopting the above technical solution, the preparation of the bactericidal composition is facilitated.
[0026] Optionally, in step S2, the weight ratio of the mixed material to water is 1:(0.1-0.3).
[0027] By adopting the above technical solution, the amount of water added to the mixed material is optimized to ensure that the mixed material and water are in full contact, and the kneading and extrusion granulation of the mixed material are achieved, thereby obtaining the sterilization granules, which not only ensures the molding of the sterilization composition, but also makes the sterilization composition have good wear resistance and stability in use, which is convenient for the transportation and storage of the sterilization composition. In multiple embodiments, the weight ratio of the mixed material and water is 1:0.2, and the weight ratio can be set to 1:0.1, 1:0.15, 1:0.25, 1:0.3 as needed, but it is not limited to the listed values, and other values not listed within the numerical range are also applicable.
[0028] In a second aspect, the present application provides a use of a fungicide composition containing oxadipamide and difenoconazole in preventing take-all disease of crops.
[0029] Optionally, the crop for which the fungicidal composition is used to protect against crop take-all disease is wheat.
[0030] Optionally, the amount of the fungicidal composition used to prevent crop take-all disease is 1000-2000 g / mu. In multiple embodiments, the amount of the fungicidal composition used to prevent crop take-all disease is 1500 g / mu, and the amount can be set to 1000 g / mu, 1100 g / mu, 1200 g / mu, 1300 g / mu, 1400 g / mu, 1600 g / mu, 1700 g / mu, 1800 g / mu, 1900 g / mu, 2000 g / mu as needed, but is not limited to the listed values, and other values not listed within the numerical range are also applicable.
[0031] Optionally, the fungicide composition is used for preventing take-all disease of crops by in-ditch application.
[0032] In summary, this application has at least the following beneficial effects: The bactericidal composition of the present application adopts oxadipamide and difenoconazole as active ingredients, and utilizes the mutual synergistic effect of the two to inhibit the growth and reproduction of the pathogenic bacteria of take-all disease, can effectively prevent and control the occurrence of take-all disease, enhance the bactericidal effect, and improve the control effect, especially showing a significant advantage in the control effect of wheat take-all disease, and the control effect is greater than 81%, which greatly reduces the impact of take-all disease on wheat yield and quality. It has the advantages of synergistic synergy, high efficacy, long-lasting efficacy, and good control effect, and can be promoted and applied on a large scale. DETAILED DESCRIPTION
[0033] In order to make the present application easier to understand, the present application will be further described in detail below in conjunction with the examples, which are merely illustrative and are not intended to limit the scope of application of the present application. The raw materials or components used in the present application can be obtained through commercial routes or conventional methods unless otherwise specified. Example
[0034] Table 1 Component contents of the sterilization composition (unit: × 10 kg) Example 1 A fungicide composition containing oxadipazole and difenoconazole, the dosage form of the fungicide composition is granules, the average particle size of the fungicide composition is 1 mm, and the components and component ratios are shown in Table 1.
[0035] Among them, the binder is ethyl cellulose; the wetting agent is tristyrylphenol polyoxyethylene ether, which is selected from Yixing Jiateng Chemical Co., Ltd.; the adsorbent is white carbon black, which is selected from Shijiazhuang Yuanjing Mineral Products Co., Ltd.; the filler is clay, which is selected from Shijiazhuang Yuanjing Mineral Products Co., Ltd.
[0036] A method for preparing a fungicide composition containing oxazolidinone and difenoconazole mainly comprises the following steps: S1. Add oxadipate, difenoconazole, a binder, a wetting agent, and an adsorbent into a mixing tank, stir for 10 minutes, add a filler, stir for 5 minutes, and obtain a mixed material.
[0037] S2. In a mixer, add the mixed material and water to knead, and then extrude and granulate in an extrusion granulator to obtain sterilization granules.
[0038] Among them, the weight ratio of the mixed material and water is 1:0.2.
[0039] S3. Dry the sterilizing particles using a refrigerated compressed air dryer, and then sieve them using a sieving machine to obtain a sterilizing composition.
[0040] Embodiment 2-5 A fungicidal composition containing oxadipamide and difenoconazole, which is different from Example 1 in that the component ratios of the fungicidal composition are different, and the component ratios of the fungicidal compositions of Examples 2-5 are shown in Table 1.
[0041] Table 2 Component contents of the bactericidal composition (unit: × 10 kg) Example 6 A fungicide composition containing oxazolidinone and difenoconazole, which is different from Example 1 in that a synergist is added to the components of the fungicide composition, and the synergist is 5-ethoxycarbonyl-2-thienylzinc bromide; and the component ratio of the fungicide composition is shown in Table 2.
[0042] A method for preparing a fungicidal composition containing oxazolidinone and difenoconazole, which is different from Example 1 in that step S1 is different.
[0043] Step S1 is specifically as follows: in a mixing tank, add oxadipate, difenoconazole, a synergist, a binder, a wetting agent, and an adsorbent, stir for 10 minutes, add a filler, stir for 5 minutes, and obtain a mixed material.
[0044] Embodiment 7-8 A fungicidal composition containing oxadipamide and difenoconazole, which is different from Example 6 in that the component ratios of the fungicidal composition are different, and the component ratios of the fungicidal compositions of Examples 7-8 are shown in Table 2.
[0045] Comparative Example Comparative Example 1 A fungicide composition containing oxadipamide and difenoconazole, which is different from Example 1 in that an equal amount of oxadipamide is used to replace difenoconazole in the components of the fungicide composition.
[0046] Comparative Example 2 A fungicide composition containing oxadipamide and difenoconazole, which is different from Example 1 in that an equal amount of difenoconazole is used to replace oxadipamide in the components of the fungicide composition.
[0047] Comparative Example 3 A fungicidal composition containing oxadipamide and difenoconazole, which is different from Example 1 in that an equal amount of tetrazolium pyrazone is used to replace difenoconazole in the components of the fungicidal composition.
[0048] Comparative Example 4 A fungicide composition containing oxamexazole and difenoconazole, which is different from Example 1 in that an equal amount of epoxiconazole is used to replace difenoconazole in the components of the fungicide composition.
[0049] Comparative Example 5 A fungicide composition containing oxazolidinone and difenoconazole, which is different from Example 1 in that an equal amount of silthiopyrad is used to replace difenoconazole in the components of the fungicide composition.
[0050] Comparative Example 6 A fungicide composition containing oxadipamide and difenoconazole, which is different from Example 1 in that an equal amount of polyoxin is used to replace oxadipamide in the components of the fungicide composition.
[0051] Performance Testing (1) Safety test Take the bactericidal composition of Examples 1-8 respectively, adopt the method of furrow application, and use the bactericidal composition for wheat sowing treatment, the wheat is selected from Jimai 22, and the use amount of the bactericidal composition is 4000g / mu. At the same time, a blank control group is made, and the blank control group uses an equal amount of filler to replace the bactericidal composition. And the test results of 7d plant height, 7d root length, 7d root number, 14d plant height, 14d root length, 14d root number, 21d plant height, 21d root length, 21d root number, 7d fresh weight growth rate, 7d growth rate inhibition rate, 14d fresh weight growth rate, 14d growth rate inhibition rate, 21d fresh weight growth rate, and 21d growth rate inhibition rate of Examples 1-8 and the blank control group are compared.
[0052] After testing, the 7d plant height, 7d root length, 7d root number, 14d plant height, 14d root length, 14d root number, 21d plant height, 21d root length, and 21d root number of Examples 1-8 were no different from those of the blank control group. The 7d fresh weight growth rate, 7d growth rate inhibition rate, 14d fresh weight growth rate, 14d growth rate inhibition rate, 21d fresh weight growth rate, and 21d growth rate inhibition rate of Examples 1-8 were no different from those of the blank control group. This shows that the bactericidal composition of the present application has good safety for wheat emergence.
[0053] (2) Efficacy test The fungicidal compositions obtained in Examples 1-8 and Comparative Examples 1-6 were respectively taken, and the fungicidal compositions were used in a field test for the prevention and control of wheat take-all disease by furrow application. The wheat was selected from Jimai 22, and the amount of the fungicidal composition was 1500 g / mu. The fungicidal composition was applied in furrows before wheat sowing. At the same time, a blank control group was prepared, and the blank control group used an equal amount of filler to replace the fungicidal composition. Random sampling was taken from the field test, and the prevention and control effects of Examples 1-8 and Comparative Examples 1-6 were tested, and the test results are shown in Table 3.
[0054] Among them, the control effect / (%)=(the incidence of wheat take-all disease at the sampling point using the filler-the incidence of wheat take-all disease at the sampling point using the fungicide composition) / the incidence of wheat take-all disease at the sampling point using the filler×100%.
[0055] Table 3 Test results Test items Control effect / (%) Example 1 86.56 Example 2 84.93 Example 3 83.54 Example 4 81.38 Example 5 87.65 Example 6 89.67 Example 7 91.83 Example 8 90.39 Comparative Example 1 62.24 Comparative Example 2 51.85 Comparative Example 3 65.17 Comparative Example 4 69.62 Comparative Example 5 67.96 Comparative Example 6 55.94 As can be seen from Table 1, the bactericidal composition of the present application has a higher control effect of 81.33-81.83%, showing the advantages of high efficacy, good activity and good control effect, meeting market demand.
[0056] Comparative Examples 1-2 and Example 1 are compared. In the components of the fungicidal composition of Comparative Example 1, meprobamate is added; in the components of the fungicidal composition of Comparative Example 2, difenoconazole is added; in the components of the fungicidal composition of Example 1, meprobamate and difenoconazole are added. It can be seen that, compared with the use of meprobamate alone or difenoconazole alone, the simultaneous use of meprobamate and difenoconazole and the use of their mutual synergistic synergy can significantly enhance the fungicidal effect and significantly improve the control effect.
[0057] Comparative Examples 3-5 and Example 1 are compared. The components of the fungicide composition of Comparative Example 3 include oxamexazole and tetrazolylpyramine; the components of the fungicide composition of Comparative Example 4 include oxamexazole and epoxiconazole; the components of the fungicide composition of Comparative Example 5 include oxamexazole and silthiopyrad; the components of the fungicide composition of Comparative Example 6 include polyoxin and difenoconazole; the components of the fungicide composition of Example 1 include oxamexazole and difenoconazole. It can be seen that compared with oxamexazole and tetrazolylpyramine, oxamexazole and epoxiconazole, oxamexazole and silthiopyrad, polyoxin and difenoconazole, the combination of oxamexazole and difenoconazole shows a significant advantage in the prevention and control of wheat take-all disease.
[0058] Compare Example 1 with Example 6. Compared with Example 1, Example 6 adds 5-ethoxycarbonyl-2-thienyl zinc bromide to the components of the fungicide composition. It can be seen that on the basis of using oxadipazole and difenoconazole as active ingredients, 5-ethoxycarbonyl-2-thienyl zinc bromide is further added. 5-ethoxycarbonyl-2-thienyl zinc bromide can promote the efficacy of oxadipazole and difenoconazole, enhance the bactericidal effect, and improve the prevention and control effect. Combined with Examples 7-8. The amount of 5-ethoxycarbonyl-2-thienyl zinc bromide added to the fungicide composition of Example 6 is 0.1%; the amount of 5-ethoxycarbonyl-2-thienyl zinc bromide added to the fungicide composition of Example 7 is 0.2%; the amount of 5-ethoxycarbonyl-2-thienyl zinc bromide added to the fungicide composition of Example 8 is 0.3%. It can be seen that with the continuous increase in the amount of 5-ethoxycarbonyl-2-thienyl zinc bromide added, the control effect shows a trend of first increasing and then decreasing, and the control effect is best when the addition amount of 5-ethoxycarbonyl-2-thienyl zinc bromide is 0.2%.
[0059] It should be noted that the embodiments described above are only used to explain the present application and do not constitute any limitation to the present application. The present application is described with reference to typical embodiments, but it should be understood that the words used therein are descriptive and explanatory words, rather than restrictive words. The present application may be modified as specified within the scope of the claims of the present application, and the present invention may be revised without departing from the scope and spirit of the present application. Although the present application described therein relates to specific methods, materials and embodiments, it does not mean that the present application is limited to the specific examples disclosed therein. On the contrary, the present application can be extended to all other methods and applications with the same functions.
Claims
1. A fungicidal composition containing meprobamate and difenoconazole, characterized in that: The active ingredients in the bactericidal composition are oxadipamide and difenoconazole, and the weight ratio of oxadipamide to difenoconazole is (2-3):
1.
2. A fungicidal composition containing oxamexyl and difenoconazole according to claim 1, characterized in that: The total mass percentage of active ingredients in the bactericidal composition is 0.5-5%.
3. A fungicidal composition containing oxamexyl and difenoconazole according to claim 1, characterized in that: The dosage form of the bactericidal composition is granules.
4. A fungicidal composition containing oxamexazole and difenoconazole according to claim 1, characterized in that: The bactericidal composition is mainly composed of the following components in percentage by weight: 0.5-5% of active ingredient, 0-0.3% of synergistic auxiliary agent, 1-3% of binder, 2-4% of wetting agent, 4-6% of adsorbent, and the balance is filler.
5. A fungicidal composition containing meprobamate and difenoconazole according to claim 4, characterized in that: The synergist is 5-ethoxycarbonyl-2-thienyl zinc bromide.
6. A fungicidal composition containing oxamexazole and difenoconazole according to claim 4, characterized in that: The binder is one or more of ethyl cellulose, carboxyethyl cellulose, carboxymethyl cellulose, polyvinyl pyrrolidone and starch.
7. A fungicidal composition containing oxamexyl and difenoconazole according to claim 4, characterized in that: The wetting agent is one or more of tristyrylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, castor oil polyoxyethylene ether, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, and sodium dioctyl sulfosuccinate.
8. A fungicidal composition containing meprobamate and difenoconazole according to claim 4, characterized in that: The adsorbent is one or more of white carbon black, activated carbon, biochar, silica gel and silicon dioxide.
9. A fungicidal composition containing oxamexazole and difenoconazole according to claim 4, characterized in that: The filler is one or more of clay, diatomaceous earth, bentonite, attapulgite and talc.
10. Use of a fungicide composition containing oxadipamide and difenoconazole as claimed in any one of claims 1 to 9 for preventing take-all disease in crops.